Cov tshuaj Hinapril: cov lus qhia rau kev siv

Tshuaj tiv thaiv kab mob siab, ACE inhibitor.

Quinapril hydrochloride yog ntsev ntawm quinapril, ib qho ethyl ester ntawm ACE inhibitor quinaprilat, uas tsis muaj ib pawg sulfhydryl.

Quinapril sai sai deesterifies nrog kev tsim ntawm quinaprilat (quinapril diacid yog lub ntsiab metabolite), uas muaj zog ACE inhibitor. ACE yog peptidyldipeptidase uas catalyzes hloov dua siab tshiab ntawm angiotensin I mus rau angiotensin II, uas muaj cov nyhuv vasoconstrictor thiab koom nrog kev tswj hwm vascular laus thiab ua haujlwm los ntawm ntau cov txheej txheem, suav nrog kev tsim ntawm aldosterone ntau lawm los ntawm adrenal cortex. Quinapril inhibits cov kev ua ntawm lub cev thiab cov nqaij mos ACE thiab yog li txo cov vasopressor kev ua si thiab kev tsim tawm ntawm aldosterone. Kev txo qis ntawm theem ntawm angiotensin II los ntawm cov lus tawm tswv yim ua rau ua rau muaj kev nce siab ntau ntxiv thiab nws cov haujlwm hauv cov ntshav ntshav.

Lub tshuab tseem ceeb ntawm cov nyhuv antihypertensive ntawm quinapril suav hais tias yog kev tsuj ntawm kev ua haujlwm ntawm RAAS, txawm li cas los xij, cov tshuaj pom tias muaj kev cuam tshuam txawm tias nyob hauv cov neeg mob ntshav qis. ACE yog qhov zoo sib xws hauv cov qauv rau kininase II, ib qho enzyme uas rhuav tshem bradykinin, peptide nrog cov khoom muaj zog vasodilating zoo. Nws tseem tsis paub meej tias kev nce ntxiv hauv qib bradykinin yog qhov tseem ceeb rau kev kho mob ntawm quinapril. Lub sijhawm ntawm cov nyhuv antihypertensive ntawm quinapril tau siab dua lub sijhawm ntawm nws cov nyhuv inhibitory rau ncig ACE. Ib qho kev txheeb ze ze ze ntawm kev tsuj tawm ntawm cov nqaij ACE thiab lub sijhawm ntawm cov nyhuv antihypertensive ntawm cov tshuaj tau qhia tawm.

ACE inhibitors, suav nrog quinapril, tuaj yeem ua rau insulin rhiab heev.

Kev siv quinapril ntawm kev noj tshuaj ntawm 10-40 mg rau cov neeg mob uas mob sib khuav mus rau mob hnyav ua rau cov ntshav siab ua rau txo cov ntshav siab ob leeg hauv kev zaum thiab sawv txoj haujlwm thiab muaj qhov cuam tshuam tsawg kawg ntawm lub plawv dhia. Cov nyhuv antihypertensive tshwm sim nws tus kheej hauv 1 teev thiab feem ntau mus txog qhov siab kawg nyob hauv 2-4 teev tom qab siv tshuaj. Hauv qee tus neeg mob, qhov siab tshaj plaws antihypertensive nyhuv yog pom 2 lub lis piam tom qab pib ntawm kev kho mob.

Cov nyhuv antihypertensive ntawm cov tshuaj thaum siv nyob rau hauv cov koob tshuaj pom zoo hauv cov neeg mob feem ntau kav 24 teev thiab tawm tsam thaum lub sij hawm ntev kho.

Kev tshawb nrhiav hemodynamic hauv cov neeg mob ntshav siab qhia tau tias kev txo ntshav siab nyob rau hauv hinapril muaj kev cuam tshuam los ntawm OPSS thiab lub raum tsis muaj zog, thaum lub plawv dhia, lub plawv dhia ntshav, lub plawv raum khiav, lub plawv txhaws thiab lim ntshav hloov me ntsis lossis tsis hloov.

Cov txiaj ntsig kho ntawm cov tshuaj hauv tib cov tshuaj txhua hnub muaj peev xwm sib piv hauv cov neeg laus (tshaj 65) thiab hauv cov neeg mob ntawm cov hnub nyoog yau, hauv cov laus dua qhov xwm txheej ntawm cov kev tsis zoo tsis nce ntxiv.

Kev siv hinapril nyob rau hauv cov neeg mob uas mob plawv tsis txaus ua rau OPSS txo, txhais tau hais tias ntshav siab, systolic thiab diastolic ntshav siab, jamming siab ntawm pulmonary capillaries thiab nce rau hauv plawv mob.

Hauv 149 cov neeg mob uas tau ua mob rau txoj hlab ntshav hla kev hla ntshav, kev kho nrog quinapril ntawm koob tshuaj 40 mg ib hnub piv nrog cov placebo ua rau txo qis qhov zaus ntawm postoperative ischemic cov teeb meem tsis pub dhau ib xyoo tom qab kev phais.

Hauv cov neeg mob uas paub tseeb txog cov mob hlab ntsha leeg mob uas tsis muaj hlab ntshav siab lossis lub plawv tsis ua haujlwm, quinapril txhim kho kev ua haujlwm tsis zoo rau cov hlab ntaws ua ntshav thiab txhaws txhaws.

Cov nyhuv ntawm quinapril ntawm kev ua haujlwm ntawm endothelial yog txuam nrog kev nce hauv nitric oxide ntau lawm. Endothelial kawg ua haujlwm yog suav tias yog cov haujlwm tseem ceeb rau kev txhim kho cov hlab ntshav atherosclerosis. Cov kab mob tseem ceeb ntawm kev txhim kho endothelial kev ua haujlwm tsis tau tsim.

Cov Tshuaj Pharmacokinetics

Kev tshem tawm, faib tawm, cov metabolism

Tom qab noj Cmax ntawm quinapril hauv ntshav, nws tau ua tiav nyob hauv 1 teev. Kev nqus ntawm cov tshuaj yog kwv yees li 60%. Noj noj tsis cuam tshuam rau qib ntawm kev nqus, tab sis tus nqi thiab qib ntawm nqus ntawm quinapril yog me ntsis txo thaum noj cov khoom noj muaj roj.

Quinapril yog metabolized rau quinaprilat (li ntawm 38% ntawm lub qhov ncauj) thiab ib feem tsawg ntawm lwm cov tshuaj tiv thaiv tsis tau. T1 / 2 ntawm quinapril los ntawm ntshav ntshav yog kwv yees li 1 teev. Cmax ntawm quinaprilat hauv ntshav tau txog li thaj tsam 2 teev tom qab noj quinapril. Kwv yees li 97% ntawm quinapril lossis quinaprilat nthuav tawm hauv ntshav cov ntshav yam muaj protein. Hinapril thiab nws cov metabolites tsis nkag rau hauv BBB.

Quinapril thiab quinaprilat tsuas yog tawm hauv cov zis (61%), nrog rau hauv cov quav (37%), T1 / 2 yog li 3 teev.

Kev noj tshuaj ntxiv

Thaum ua kev kho mob monotherapy rau kub siab, qhov kev xav tau pib ntawm Accupro® hauv cov neeg mob uas tsis tau txais diuretics yog 10 mg lossis 20 mg ib hnub ib zaug. Ua raws li kev kho mob tus kab mob, qhov tshuaj tuaj yeem nce (ob npaug) rau kev saib xyuas txij nkawm ntawm 20 mg lossis 40 mg rau ib hnub, uas feem ntau tau muab tshuaj kho 1 koob tshuaj lossis faib ua 2 ntu. Raws li txoj cai, koob tshuaj yuav tsum tau hloov pauv ntawm 4 ncua sijhawm. Feem ntau ntawm cov neeg mob, kev tswj ntshav siab txaus thaum siv sijhawm kho ntev tuaj yeem ua tiav los ntawm kev siv cov tshuaj 1 zaug nyob rau ib hnub. Qhov nyiaj pab ntau tshaj txhua hnub yog 80 mg.

Hauv cov neeg mob uas tseem noj cov tshuaj diuretics, qhov kev xav kom pom zoo ntawm thawj zaug ntawm Accupro® yog 5 mg, yav tom ntej nws tau nce ntxiv (raws li tau hais los saum toj no) kom txog thaum pom cov txiaj ntsig zoo.

Hauv kev mob plawv tsis ua haujlwm, kev siv cov tshuaj yog qhia raws li kev txhawb ntxiv rau kev kho mob nrog diuretics thiab / lossis mob plawv glycosides. Cov koob tshuaj pom zoo thawj zaug hauv cov neeg mob uas muaj mob plawv tsis zoo yog 5 mg 1 lossis 2 zaug hauv ib hnub, tom qab siv cov tshuaj, tus neeg mob yuav tsum raug soj ntsuam txhawm rau txhawm rau txhawm rau txhawm rau paub txog tus mob hypotension arterial hypotension. Yog tias qhov thev taus ntawm thawj koob tshuaj Accupro® yog qhov zoo, ces nws tuaj yeem nce ntxiv rau qhov tau txais txiaj ntsig zoo, uas feem ntau 10-40 mg ib hnub hauv 2 koob tshuaj sib luag nrog kev sib xyaw nrog kev kho concomitant.

Yog tias muaj mob raum ua rau lub raum tsis zoo, cov lus pom zoo thawj zaug ntawm Accupro® yog 5 mg rau cov neeg mob CC ntau dua 30 ml / min thiab 2.5 mg hauv cov neeg mob CC tsawg dua 30 ml / min. Yog tias kev thev taus rau thawj koob tshuaj yog qhov zoo, tom qab ntawd hnub tom ntej, Akkupro® tuaj yeem siv tshuaj 2 Thaum tsis muaj qhov mob ntshav txaus los yog muaj qhov tsis zoo hauv lub raum ua haujlwm, qhov tshuaj tuaj yeem nce ntxiv nyob rau ntawm txhua lub limtiam, ua rau qhov kev soj ntsuam thiab hemodynamic muaj kev cuam tshuam.

Muab cov ntaub ntawv soj ntsuam thiab kws kho mob hauv cov neeg mob uas lub raum tsis zoo, ua rau kom txhaj thawj zaug yog xav kom raug xaiv raws li hauv qab no.

Txoj kev ntawm daim ntawv thov

Ua raws li kev kho mob tus kab mob, qhov tshuaj tuaj yeem nce (ob npaug) rau kev saib xyuas txij 20 lossis 40 mg / hnub, uas feem ntau tau muab tshuaj rau 1 lossis 2 koob tshuaj. Raws li txoj cai, koob tshuaj yuav tsum tau hloov pauv ntawm 4 ncua sijhawm. Hauv feem ntau cov neeg mob, kev siv cov tshuaj Hinapril-SZ 1 lub sijhawm ib hnub tso cai rau koj kom ua tiav qhov lus teb kho zoo. Qhov siab tshaj plaws niaj hnub noj yog 80 mg / hnub.
Kev siv tib lub sijhawm nrog cov tshuaj diuretics: qhov kev pom zoo thawj zaug ntawm Hinapril-SZ hauv cov neeg mob uas tseem siv tshuaj diuretics yog 5 mg ib hnub ib zaug, thiab tom qab ntawd nws tau nce (raws li tau piav qhia saum toj no) kom txog thaum qhov kev kho mob zoo tshaj plaws tau tiav.
CHF
Qhov pom zoo pib koob tshuaj Hinapril-SZ yog 5 mg 1 lossis 2 zaug ib hnub.
Tom qab noj cov tshuaj, tus neeg mob yuav tsum nyob hauv kev saib xyuas kev kho mob txhawm rau txhawm rau txheeb xyuas cov tsos mob ntsig txog hlab ntsha o. Yog tias pib koob tshuaj Hinapril-SZ zoo siab, nws tuaj yeem nce ntxiv txog 10-40 mg / hnub los ntawm kev muab faib ua 2 koob.
Lub raum khiav tsis zoo
Muab cov ntaub ntawv soj ntsuam thiab kws kho mob hauv cov neeg mob uas lub raum ua tsis zoo, thawj qhov kev xav tau raug pom zoo kom raug xaiv raws li hauv qab no:
Thaum Cl creatinine ntau tshaj 60 ml / min, qhov kev pom zoo thawj zaug yog 10 mg, 30-60 ml / min - 5 mg, 10-30 ml / min - 2.5 mg (1/2 tab. 5 mg).
Yog tias kev thev taus mus rau thawj zaug tshuaj yog qhov zoo, tom qab ntawd cov tshuaj Hinapril-SZ tuaj yeem siv 2 zaug ib hnub. Cov koob tshuaj ntawm Hinapril-SZ tuaj yeem maj mam nce ntxiv, tsis yog ntau tshaj ib zaug ib asthiv, suav txog qhov kev soj ntsuam, hemodynamic teebmeem, nrog rau lub raum ua haujlwm.
Cov neeg laus cov neeg mob
Qhov pom zoo pib koob tshuaj Hinapril-SZ hauv cov neeg laus yog 10 mg ib hnub ib zaug, yav tom ntej nws tau nce ntxiv kom txog thaum qhov kev kho mob zoo tshaj plaws tau tiav.

Sab sij huam

Cov xwm txheej tsis zoo nrog quinapril feem ntau yog mob me me thiab hloov pauv. Feem ntau, mob taub hau (7.2%), kiv taub hau (5.5%), hnoos (3.9%), qaug zog (3.5%), mob ntsws (3.2%), xeev ntuav thiab / lossis ntuav (2.8%) thiab myalgia (2.2%). Nws yuav tsum raug sau tseg tias qee zaus, hnoos tsis muaj txiaj ntsig, mob siab thiab ploj mus tom qab kev kho mob nres.
Qhov ntau zaus ntawm kev thim tawm ntawm quinapril yog qhov tshwm sim ntawm cov kev mob tshwm sim tau pom nyob rau hauv 5.3% ntawm cov neeg mob.
Hauv qab no yog cov npe ntawm cov kev tsis zoo uas tau faib tawm los ntawm cov khoom hauv nruab nrog cev thiab qhov ntau zaus tshwm sim (WHO kev faib tawm): feem ntau ntau dua li ntawm 1/10, feem ntau los ntawm ntau tshaj li ntawm 1/100 txog tsawg dua 1/10, tsis xws li los ntawm ntau dua li 1/1000 txog tsawg dua 1 / 100, tsis tshua muaj - los ntawm ntau dua li ntawm 1/10000 txog tsawg dua 1/1000, tsis tshua muaj - los ntawm tsawg dua 1/10000, suav nrog cov tib neeg cov lus.
Los ntawm sab hauv ntawm cov leeg poob siab: feem ntau - mob taub hau, kiv taub hau, pw tsaug zog, mob plab, muaj zog ntau zog, ua tsis tiav - kev nyuaj siab, npau taws ntxiv, nkees, mob duav.
Los ntawm cov teeb meem zom zaub mov: feem ntau - xeev siab thiab / lossis ntuav, raws plab, dyspepsia, mob plab, hle khaub ncaws - qhuav qog ua pa ntawm lub qhov ncauj lossis caj pas, mob plab, txha nqaj *, mob caj pas, mob plab hnyuv, ua kom ntshav tawm, tsis tshua muaj - kab mob siab.
Kev cuam tshuam dav dav thiab kev tsis txaus siab nyob ntawm qhov chaw txhaj tshuaj: tsis xws luag - edema (peripheral lossis generalized), malaise, kis kab mob.
Los ntawm cov roj ntsha ncig thiab lymphatic systems: ua haujlwm yam tsis muaj tseeb - hemolytic anemia *, thrombocytopenia *.
Ntawm ib feem ntawm CVS: feem ntau - cov cim txo qis hauv cov ntshav siab, tsis xws luag - angina pectoris, palpitations, tachycardia, lub plawv tsis ua haujlwm, myocardial infarction, mob stroke, nce ntshav siab, mob plawv, poob siab postural hypotension *, tsaus muag *, cov tsos mob ntawm vasodilation.
Los ntawm lub tshuab ua pa, hauv siab thiab mediastinal plab hnyuv siab raum: feem ntau - hnoos, dyspnea, pharyngitis, mob hauv siab.
Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: ua tsis xws luag - alopecia *, exfoliative dermatitis *, nce tawm hws, pemphigus *, kev tawm tsam *, khaus, pob.
Los ntawm sab ntawm musculoskeletal thiab cov ntaub so ntswg mob: feem ntau - mob nraub qaum, ua tsis xws luag - arthralgia.
Los ntawm ob lub raum thiab lub chaw tso zis: paim ntaws - mob txeeb zig, mob raum tsis ua haujlwm.
Los ntawm cov qau thiab cov qog mammary: ncaug - ib qho kev txo qis hauv potency.
Los ntawm sab ntawm cov khoom ntawm lub zeem muag: pheej ntsib - ntus tsis pom kev.
Los ntawm sab hauv lub nruab nrog cev: tiv thaiv tsis txaus - anaphylactic kev ua xua *, tsis tshua muaj - angioedema.
Lwm yam: tsis tshua muaj - eosinophilic pneumonitis.
Qhov ntsuas pom: tsis tshua muaj tshwm sim - agranulocytosis thiab neutropenia, txawm hais tias muaj kev sib cav nrog kev siv hinapril tseem tsis tau tsim.
Hyperkalemia: saib "Cov lus qhia tshwj xeeb."
Creatinine thiab ntshav urea nitrogen: kev nce ntxiv (ntau dua 1,25 zaus piv nrog VGN) ntawm cov ntshiab si creatinine thiab ntshav urea nitrogen tau pom nyob hauv 2 thiab 2% ntawm cov neeg mob tau txais quinapril monotherapy, ntsig txog. Qhov tshwm sim ntawm qhov nce ntawm cov teeb meem no hauv cov neeg mob ib txhij txais cov tshuaj diuretics yog qhov siab dua nrog kev siv quinapril ib leeg. Nrog rau kev kho ntxiv, ntsuas feem ntau rov qab mus rau qhov qub.
* - Tsis tshua muaj qhov tshwm sim tsis zoo lossis sau tseg thaum tshawb fawb tom qab muag.
Nrog rau kev siv ACE cov tshuaj tiv thaiv ib txhij thiab kev npaj kub (sodium acurothiomalate, iv), cov tsos mob tau piav qhia, suav nrog kev tso dej tawm ntsej muag, xeev siab, ntuav, thiab txo ntshav siab.

Cov lus sib xyaw thiab daim ntawv ntawm cov tshuaj

Qhov tseem ceeb tseem ceeb ntawm cov tshuaj Hinapril yog quinapril hydrochloride.

Tsis tas li ntawd nyob rau hauv nws muaj pes tsawg leeg muaj qee qhov tuaj yeem:

• mis nyuj qab zib (lactose monohydrate),
• yooj yim aqueous magnesium carbonate,
• primellose (croscarmellose sodium),
• povidone
• magnesium stearate,
• aerosil (colloidal silicon dioxide).

Daim ntawv ntawm tso tawm cov tshuaj Hinapril yog hloov cov ntsiav tshuaj, txheej nrog xim daj txheej txheej. Lawv yog cov biconvex thiab muaj kev pheej hmoo. Hauv tshooj hla, cov tub ntxhais muaj qhov xim dawb, lossis yuav luag xim dawb.

Cov tshuaj no tau nthuav tawm hauv cov hlwv pob muaj 10 lossis 30 ntsiav tshuaj. Nws kuj muaj nyob rau hauv lub rhawv thiab fwj ua cov khoom siv polymer.

Kev ntsuas rau siv

Hinapril ntsiav tshuaj yog tshuaj rau kho cov kab mob xws li:

Cov tshuaj no tuaj yeem siv ob qho tib si hauv kev kho mob mono-kev kho mob, thiab hauv kev sib xyaw nrog beta-blockers thiab thiazide diuretics.

Cuam tshuam nrog rau lwm yam tshuaj

Thaum siv cov tshuaj Hinapril nrog lithium kev npaj, cov neeg mob tuaj yeem nce lithium cov ntsiab lus hauv cov ntshav cov ntshav. Kev phom sij ntawm cov roj ntsha lithium intoxication nce ntxiv rau thaum muaj kev sib koom tes nrog cov neeg ua hauj lwm diuretic.

Kev siv ua ke ntawm quinapril nrog cov tshuaj hypoglycemic ua rau kev nce hauv lawv cov kev txiav txim siab.

Kev siv cov ntsiav tshuaj no nrog kev npaj muaj ethanol yog qhov tsis lees paub. Qhov tshwm sim tsis zoo ntawm qhov kev sib txuam no yog qhov nce ntxiv hauv cov cuam tshuam antihypertensive.

Noj ntau dhau

Yog tias ib tus neeg mob yuam kev siv ntau dua li cov tshuaj pom zoo ntawm Hinapril, qhov no tuaj yeem ua rau cov ntshav nce siab thiab cov lus tawm hauv cov ntshav siab, qhov muag tsis pom kev, ua kom tsis muaj zog thiab kiv taub hau.

Nyob rau hauv cov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tsum tau ua tam sim ntawd ua kom muaj kev mob tshwm sim thiab rau lub sijhawm tsis kam noj cov tshuaj.

Koj tuaj yeem rov teem sijhawm tom qab tsuas tham sab laj nrog kws kho mob.

Cov Yuav Tsum Muaj

Hinapril ntsiav tshuaj yog contraindicated hauv:

• intolerance mus rau lub Cheebtsam ntawm cov tshuaj,
• lub raum tsis ua hauj lwm zoo,
• hyperkalemia
• keeb kwm ntawm angioedema,
• angioedema, uas yog caj ces los yog idiopathic hauv xwm,
• mob ntshav qab zib
• cev xeeb tub thiab lactation.

Ntxiv rau, cov tshuaj no tsis tau qhia rau kho mob rau cov neeg mob hnub nyoog qis dua 18 xyoo.

Cov lus thiab cov xwm txheej ntawm kev cia

Lub txee lub neej ntawm Hinapril ntsiav tshuaj yog peb xyoos txij li hnub tsim khoom lag luam. Nws raug nquahu kom muab lawv nyob rau qhov kub txog +25 degrees, hauv qhov chaw tsis zoo rau menyuam yaus, kev tiv thaiv zoo los ntawm lub teeb ncaj thiab ya raws.

Hauv cov khw muag tshuaj Lavxias Kev yuav cov tshuaj Hinapril, koj yuav tsum muab tshuaj rau koj. Tus nqi nruab nrab ntawm cov ntsiav tshuaj no tsawg thiab kom txog li 80-160 rubles rau ib pob.

Nyob rau hauv Ukraine Tus nqi ntawm Hinapril kuj tseem tsawg - kwv yees li 40-75 hryvnia.

Hauv kev lag luam kws tshuaj niaj hnub, ntau cov tshuaj zoo tshuaj ntawm cov ntsiav tshuaj hinapril yog nthuav tawm. Cov feem nrov thiab nrhiav tom qab ntawm lawv suav nrog:

Nws tsis pom zoo kom xaiv ib qho analog ntawm Hinapril ntawm nws tus kheej. Rau cov laj thawj no, koj yuav tsum sab laj nrog tus kws kho mob uas tsim nyog uas yuav sau cov kev xaiv zoo tshaj plaws raws li kev kuaj mob thiab tus yam ntxwv ntawm tus neeg mob.

Cov tshuaj Hinapril tau txais kev tshuaj xyuas zoo vim nws qhov ua tau zoo, tus nqi pheej yig thiab kev zam tau yooj yim los ntawm cov neeg mob feem ntau.

Cov neeg uas tau siv cov tshuaj no rau kev tiv thaiv thiab kho kom zoo, nco ntsoov tias hinapril yooj yim thiab txo cov ntshav siab, thiab tseem txo tau cov mob hauv lub plawv tsis ua haujlwm ntev. Cov kev mob tshwm sim me yog feem ntau cuam tshuam nrog kev tsis ua raws li txoj cai rau kev noj tshuaj.

Koj tuaj yeem nyeem ntxiv txog cov lus pom thiab kev txheeb xyuas kawg ntawm kab lus no.

Yog tias koj tus kheej paub txog cov tshuaj Hinapril, siv sijhawm me ntsis thiab tawm koj kev tshuaj xyuas txog nws. Qhov no yuav pab lwm tus siv thaum xaiv tshuaj.

Xaus

Yog tias koj npaj siab yuav noj cov tshuaj Hinapril rau cov tshuaj kho kom zoo lossis ua kom muaj txiaj ntsig zoo, nco ntsoov nqa mus rau hauv tus lej nws cov haujlwm tseem ceeb.

1. Hinapril muaj nyob rau hauv cov qauv hauv cov ntsiav tshuaj rau kev siv ncauj.
2. Ua raws li kev kuaj mob thiab tus mob ntawm tus neeg mob, lub sijhawm pib ntawm cov tshuaj no yog 5 lossis 10 mg. Sij hawm dhau los, hauv kev saib xyuas ntawm tus kws kho mob, nws tuaj yeem raug nce los ntawm kev faib ua ob txoj hauv kev.
3. Qhov ntau tshaj txhua hnub ntau npaum li cas ntawm cov tshuaj yog 80 mg.
4. Nws tsis tuaj yeem lees txais cov tshuaj no rau cov poj niam thaum cev xeeb tub thiab lactation.
5. Nyob rau hauv cov ntaub ntawv ntawm kev siv ntau dhau ntawm cov tshuaj, ib tug ntse txo nyob rau hauv ntshav siab thiab tshwm sim ntawm dav tsis muaj zog yog tau. Yuav kom tshem tawm cov mob no, kev kho mob kev ceeb toom yuav tsum muaj.
6. Hinapril tsis tau sau tseg rau cov neeg mob hnub nyoog qis dua 18 xyoo.
7. Kev siv ua ke ntawm Hinaprir ntsiav tshuaj nrog rau cov tshuaj uas muaj lithium thiab ethanol yog qhov tsis lees txais.

Tshuaj muab tshuaj

Raws li tau hais dhau los, cov tshuaj yuav tsum tau noj ntawm qhov ncauj. Ntxo ib ntsiav tshuaj yog qhov tsis tseem ceeb. Haus nws nrog dej kom ntau. Qhov ntau npaum ntawm cov tshuaj nyob ntawm tus kabmob uas tus neeg mob tau sib ntaus nrog.

Nrog arterial tawg siab, monotherapy yog kws kho. Hauv qhov no, koj yuav tsum tau noj 10 mg ntawm "Hinapril" ib hnub ib zaug. Tom qab 3 lub lis piam, ib qho kev nce ntxiv ntawm koob tshuaj txhua hnub rau 20-40 mg tau tso cai. Nws tuaj yeem faib ua 2 zaug tom qab sib txig sib luag ntawm lub sijhawm.

Yog tias yuav tsum tau txhaj, cov tshuaj ntawm cov tshuaj mus rau tus neeg mob uas mob ntshav tawm ntawm lub cev tau nce txog 80 mg. Cov kev ntsuas zoo li no feem ntau tsim nyog yog tias, tom qab 3 lub lis piam tom qab pib kho, kev hloov pauv zoo tsis tuaj yeem pom.

Thaum muaj mob ntsws lossis mob plawv tsis zoo, nws raug nquahu kom pib noj Hinapril nrog 5 mg. Thoob plaws hauv kev kho mob, nws yog qhov yuav tsum tau nyob hauv kev saib xyuas ntawm tus kws tshaj lij txhawm rau txhawm rau txhawm rau txiav txim siab txog kev txhim kho ntawm hypotension hauv ib tus neeg mob.

Yog tias qhov xwm txheej nrog lub siab tsis hloov, qhov noj ntau ntxiv rau 40 mg ib hnub twg. Cov kws kho mob uas sau ntawv tshuaj xyuas txog cov tshuaj paub meej tias muaj kev hloov pauv rau qhov xwm txheej zoo dua qub nrog kev hloov kho ntawm txoj kev kho mob.

Nws yog ib qho tseem ceeb rau kev noj tshuaj tib lub sijhawm.

Siv rau lub sijhawm menyuam yaus thiab hnub nyoog laus

Cov tshuaj yog contraindicated rau cov neeg uas tseem tsis tau muaj 18 xyoo. Yog li ntawd, nws siv nyob rau hauv thaum yau yog suav hais tias yog tsis tsim nyog.

Cov neeg mob uas muaj hnub nyoog tshaj 65 xyoos yuav tsum xub noj cov tshuaj nrog qhov ntau npaum li 10 mg. Tom qab, nws nce tau tso cai kom txog rau thaum lub caij thaum zoo tshwm sim ntawm kev kho mob.

Ua ntej pib txoj kev kho mob, cov neeg laus laus yuav tsum tau mus kuaj mob hauv chaw kho mob. Qhov no yog qhov yuav tsum tau ua ua ntej uas lav txog kev nyab xeeb ntawm nws txoj kev kho mob nrog Hinapril.

Cov neeg laus yuav tsum kuaj ua ntej pib kev kho mob

Pathology ntawm lub siab thiab lub raum

Cov neeg mob uas muaj kab mob siab thiab lub raum tuaj yeem siv cov tshuaj, tab sis nyob rau hauv kev saib xyuas tag nrho ntawm cov kws kho mob koom. Cov kev kho mob tsuas yog tso cai nkaus xwb rau qee cov pathologies uas cuam tshuam kev ua haujlwm ntawm kev ua haujlwm sab hauv. Yog tias muaj, koj yuav tsum tau ua tib zoo saib xyuas qhov tshuaj ntawm "Hinapril" thiab tsis muaj xwm txheej dab tsi kom nce nws yam tsis muaj kev xav tau thiab tau txais kev tso cai los ntawm cov kws tshaj lij.

Cov lus qhia tshwj xeeb

Cov lus qhia rau kev siv ntawm "Hinapril" muab cov lus qhia tshwj xeeb uas yuav tsum tau xav txog thaum kos cov txheej txheem kho raws li cov tshuaj no.

Cov tshuaj tsis tuaj yeem siv nyob rau txhua lub sijhawm ntawm cev xeeb tub. Nws yuav tsum tsis txhob raug coj los ntawm cov poj niam uas muaj hnub nyoog yug me nyuam uas zam kev siv cov tshuaj tiv thaiv niaj hnub thaum sib deev. Yog tias cev xeeb tub tau tshwm sim ncaj qha thaum ua haujlwm ntawm Hinapril, ces tus neeg mob yuav tsum tso tseg nws txoj kev siv txuas ntxiv. Sai npaum li cas cov tshuaj tau muab tshem tawm, kev cuam tshuam tsawg dua nws yuav ua rau tus me nyuam hauv plab thiab leej niam muaj me nyuam.

Cov xwm txheej raug kaw cia thaum tus menyuam yaus yug los yam tsis muaj qhov txawv txav ntawm lub cev. Nyob rau cov xwm txheej zoo li no, cov menyuam yaus uas lawv niam noj cov tshuaj no yog ua tib zoo saib xyuas. Cov kws kho mob txaus siab tshwj xeeb rau tus menyuam cov ntshav siab.

Nrog kev ceev faj, cov tshuaj yog tawm rau cov neeg mob uas tau pom tias muaj lub raum lossis lub cev tsis ua haujlwm zoo. Cov tshuaj noj nrog cov kev kuaj mob zoo li no tsuas yog noj raws qhov txwv txiav. Tsis tas li ntawd, tus neeg mob tau tas li rau qee yam kev kuaj, uas tso cai rau lub sijhawm ua kom pom kev tsis pom kev hauv lub cev ntawm qhov muaj teeb meem sab hauv lub cev vim kev kho nrog Hinapril.

Yeeb tshuaj sib cuam tshuam

Yog tias koj noj cov tshuaj nrog tetracycline tib lub sijhawm, koj tuaj yeem ua tiav qhov tseem ceeb txo qis hauv kev nqus ntawm cov tshuaj thib ob. Cov nyhuv no yog vim muaj qhov haujlwm tshwj xeeb ntawm magnesium carbonate, uas ua haujlwm pabcuam ntu hauv Hinapril.

Yog hais tias tus neeg mob noj cov roj ntsha lithium ua ke nrog ACE inhibitors, ces cov ntsiab lus ntawm thawj qhov hauv cov ntshav cov ntshav nce ntxiv. Cov tsos mob ntawm qaug cawv nrog cov tshuaj yeeb dej caw no tseem pib ua vim muaj cov tshuaj sodium ntau ntxiv. Yog li, nws yuav tsum siv cov tshuaj no nrog kev ceev faj yog tias tsim nyog, kev tswj hwm.

Siv tib lub tshuaj diuretics nrog Hinapril raug tso cai. Tab sis tib lub sijhawm muaj qhov nce ntawm hypotensive nyhuv. Yog li, nws yuav tsum tau ua tib zoo xaiv cov tshuaj ntawm ob qho tshuaj txhawm rau kom tsis txhob cuam tshuam ntawm tus neeg mob lub xeev kev noj qab haus huv.

Nrog ceev faj thiab nyob rau hauv kev tswj ua tiav ntawm theem ntawm cov poov tshuaj hauv cov ntshav, koj tuaj yeem sib xyaw ib qho kev noj tshuaj nrog cov tshuaj uas yog rau pawg ntawm cov potassium-sparing diuretics. Cov poov tshuaj thiab cov ntsev hloov pauv, uas tseem muaj cov khoom no, koom nrog tib pawg.

Nrog rau kev tswj hwm ntawm cov tshuaj thiab dej cawv, ib qho kev nce siab hauv kev nqis tes ua ntawm cov tshuaj yeeb dej caw “Hinapril” tau pom.

Cov ntsiav tshuaj rov ua dua txhim kho cov nyhuv ntawm cov tshuaj, uas yog sib npaug rau ib qho overdose

Kev kho nrog ACE inhibitors tuaj yeem ua rau cov ntshav qab zib hauv cov neeg mob tshwm sim. Qhov tshwm sim no tau sau tseg nyob hauv cov neeg mob ntshav qab zib uas noj tshuaj insulin lossis hypoglycemic rau kev siv sab hauv. Cov tshuaj yuav tsuas yog txhim kho lawv cov nyhuv.

Rov qab siv cov tshuaj hauv qhov ntau npaum li cas ntawm 80 mg nrog atorvastatin hauv kev noj tshuaj ntawm 10 mg tsis ua rau muaj kev hloov pauv tseem ceeb hauv kev ua haujlwm ntawm qhov khoom thib ob.

Ib qho tshuaj noj tuaj yeem pab txhawb ntxiv kom muaj kev tiv thaiv leukopenia hauv cov neeg mob uas tau noj ib txhij cov tshuaj allopurinol, tshuaj tiv thaiv kab mob, lossis tshuaj cytostatic.

Ua kom muaj zog ntawm kev ua haujlwm ntawm cov nquag tiv thaiv ntawm Hinapril yog pom thaum nws ua ke nrog cov tshuaj yeeb tshuaj, tshuaj loog dav dav thiab cov tshuaj tiv thaiv kev tiv thaiv.

Ob qhov thaiv tag nrho ntawm RAAS kev ua haujlwm tau nyob rau hauv kev tswj hwm aliskiren lossis ACE inhibitors tib lub sijhawm. Cov txiaj ntsig tsis zoo yog feem ntau pom tawm tsam keeb kwm ntawm kev txo qis ntshav siab, nrog rau kev txhim kho ntawm hyperkalemia.

Cov kws tshwj xeeb xav kom cov neeg mob tsis kam sib koom ua ke ntawm cov tshuaj nrog aliskiren thiab cov tshuaj uas muaj cov tshuaj no, nrog rau cov tshuaj uas tiv thaiv RAAS hauv cov xwm txheej hauv qab no:

1. Nyob rau hauv muaj ntshav qab zib mellitus nrog kev puas tsuaj rau lub hom phiaj cov kabmob, li no yam tsis muaj kev cuam tshuam,
2. Yog tias muaj mob lub raum,
3. Nrog rau kev txhim kho lub xeev ntawm hyperkalemia, uas yog tus cwj pwm los ntawm cov ntsuas ntau dua 5 mmol / l,
4. Nrog rau lub plawv ntev tsis ua haujlwm lossis kev txhim kho tawg.

Cov tshuaj uas ua rau inhibition ntawm pob txha muaj nuj nqi nce qhov ntau ntxiv ntawm agranulocytosis lossis neutropenia.

Cov neeg mob uas sib xyaw cov tshuaj nrog estramustine lossis DPP-4 inhibitors feem ntau muaj kev pheej hmoo ntawm kev tsim mob angioedema.

Kev ntsuas thiab tus nqi

Ib qho ntawm cov analogues ntawm hinapril nrog tib lub tshuaj nquag

Txhawm rau yuav Hinapril hauv khw muag tshuaj, koj yuav tsum muab daim ntawv yuav tshuaj los ntawm kws kho mob rau tus kws muag tshuaj. Nws tus nqi yog nyob ntawm ntau tus naj npawb ntawm cov ntsiav tshuaj hauv pob ntawv yuav khoom. Tus nqi nruab nrab ntawm cov tshuaj yog txwv rau 80-160 rubles. Daim ntawv teev cov ncauj lus kom ntxaws ntawm cov tshuaj tuaj yeem nrhiav tau hauv cov chaw muag tshuaj.

Rau qee qhov laj thawj, cov kws kho mob yuav tsum hloov cov tshuaj uas tus kws kho mob tau tso rau tus neeg mob kom nws noj tshuaj noj tau. Cov tshuaj hauv qab no yog muab los hloov Hinapril:

Cov lus qhia tsuas yog xaiv tau los ntawm tus kws kho mob koom xwb. Tus neeg mob yuav tsum tsis txhob ua qhov no ntawm nws tus kheej, vim nws pheej hmoo ua qhov tsis raug uas yuav cuam tshuam loj rau kev kho mob thiab nws txoj kev noj qab haus huv feem ntau.

Yog tias yog vim li cas tus neeg mob tsis haum rau kev kho mob nrog Hinapril, nws yuav tsum qhia tus kws kho mob uas koom nrog txog. Nws yuav sim xaiv cov tshuaj kom haum rau nws, tsom mus rau tus neeg mob qhov teeb meem thiab kev noj qab haus huv tam sim no. Raws li txoj cai, xws li ib qho kev xav tau tshwm sim yog tias tus neeg mob tau contraindications rau kev noj tshuaj lossis kev txhim kho cov kev mob tshwm sim ntawm lub cev mus rau qhov tseem ceeb ntawm cov tshuaj.

Khinapril pib txais nws txawm tias thaum nws tau kho hauv tsev kho mob. Tus kws kho mob tau soj ntsuam kuv tus mob tas li, vim nws tau ntshai tsam muaj mob tshwm sim ntau vim yog mob raum. Qhov zoo, tsis muaj teeb meem pom lawv tus kheej. Feem ntau, Kuv yuav tsum tau noj cov tshuaj kom txog 6 lub hlis. Muaj ntau zaus, ntawm kev pom zoo ntawm kws kho mob, nce nws qhov ntau npaum. Qhov kev txiav txim ntawm "Khinapril" tau ua tiav txaus, vim nws tau pab daws cov teebmeem ntshav siab, uas tau cuam tshuam ntau xyoo dhau los. Txawm hais tias muaj qee zaus, ntshav siab tseem nce ntxiv, txawm hais tias tsis ntau npaum li ua ntej pib kev kho tshuaj.

Kuv pib muaj teeb meem nrog lub siab thaum ntxov. Txawm hais tias feem ntau xws li cov kab mob thab cov neeg laus. Tus kws kho mob tau tawm tswv yim hais tias ntaus lawv nrog Hinapril. Nws ceeb toom tam sim ntawm qhov ua tau tshwm sim ntawm kev phiv, yog li nws tau hais tseg yam tsawg kawg ntawm cov tshuaj. Kuv siv cov tshuaj raws li kev kho mob. Txhua yam twb mus zoo. Tab sis tsis ntev los no, cov ntsiab lus tsis tsaug zog pib txhawj xeeb, txawm tias kuv sim pw txaus. Qhov no yog qhov cuam tshuam ib sab uas tau ua rau nws tus kheej hnov. Yog tias qhov xwm txheej tsis zoo, Kuv yuav nug tus kws kho mob kom muab ib qho piv txwv ntawm "Hinapril," vim tias muaj cov kab mob hauv lub cev tsis haum rau kuv.

Nosological kev faib tawm (ICD-10)

Cov Tshuaj Hauv Tshuaj

ACE yog ib qho enzyme uas ua rau muaj kev hloov pauv ntawm angiotensin I rau angiotensin II, uas muaj cov nyhuv vasoconstrictor thiab nce vascular suab, suav nrog vim muaj kev txhawb nqa ntawm lub zais zais ntawm aldosterone los ntawm adrenal cortex. Quinapril kev sib tw inhibits ACE thiab ua rau muaj kev cuam tshuam tsawg ntawm vasopressor kev ua ub no thiab aldosterone secretion.

Kev tshem tawm ntawm cov txiaj ntsig tsis zoo ntawm angiotensin II ntawm kev tso zis tso tawm los ntawm kev tawm tswv yim ua rau muaj kev nce ntxiv ntawm plasma renin kev ua si. Nyob rau tib lub sijhawm, kev txo qis hauv cov ntshav siab yog los ntawm kev txo lub plawv thiab kev tawm tsam ntawm cov hlab ntsha hauv lub raum, thaum hloov pauv hauv lub plawv dhia, lub plawv tawm, cov ntshav raum khiav, lub plawv txhaws thiab qhov lim pom yog qhov tseem ceeb lossis tsis tuaj.

Hinapril tsub kom ib ce thev taus.Nrog kev siv ntev, nws txhawb nqa kev thim rov qab ntawm myocardial hypertrophy hauv cov neeg mob ntshav siab, txhim kho cov ntshav cov ntshav mus rau ischemic myocardium. Txhim kho txoj hlab ntshav siab thiab lub raum khiav ntshav. Txo platelet aggregation. Qhov pib ntawm kev ua tom qab noj ib koob tshuaj yog tom qab 1 teev, qhov siab tshaj tom qab 2-4 teev, lub sijhawm ua haujlwm nyob ntawm qhov ntsuas ntau npaum li cas (txog 24 teev). Ib qhov kev pabcuam hais tawm hauv lub tsev khomob nce mus ob peb lub lis piam tom qab pib kho.

Cev xeeb tub thiab lactation

Kev siv cov tshuaj Hinapril-SZ yog contraindicated thaum cev xeeb tub, hauv cov poj niam npaj muaj cev xeeb tub, zoo li hauv cov poj niam muaj hnub nyoog yug me nyuam uas tsis siv txoj hauv kev muaj txiaj ntsig txhim kho.

Cov poj niam ntawm kev muaj me nyuam hnub nyoog uas tau noj tshuaj Hinapril-SZ yuav tsum siv txoj hauv kev muaj txiaj ntsig kom muaj txiaj ntsig.

Thaum kuaj pom lub cev xeeb tub, cov tshuaj Hinapril-SZ yuav tsum tsis ua sai li sai tau.

Kev siv cov tshuaj ACE inhibitors thaum cev xeeb tub yog ua ke los ntawm kev pheej hmoo siab ntxiv ntawm cov hlab ntsha hauv lub plawv thiab cov hlab ntsha ntawm cov menyuam hauv plab. Ntxiv rau, tiv thaiv keeb kwm yav dhau los ntawm kev noj tshuaj ACE inhibitors thaum cev xeeb tub, mob oligohydramnios, yug ntxov ntxov, yug ntawm cov menyuam muaj hlab ntsha hypotension, mob raum (nrog rau mob raum tsis ua haujlwm), cranial hypoplasia, lim hiam kev ua haujlwm, craniofacial malformations, pulmonary hypoplasia, mob hlab ntsha hauv lub hlwb. kev loj hlob, qhib ductus arteriosus, nrog rau me nyuam hauv plab tuag thiab kev tuag tshiab. Feem ntau, oligohydramnios tau kuaj pom tom qab tus me nyuam hauv plab tau ua tsis tau zoo.

Cov menyuam yug tshiab uas tau raug tshuaj ACE inhibitors nyob rau hauv utero yuav tsum tau soj ntsuam txhawm rau txhawm rau txhawm rau txhawm rau soj ntsuam cov leeg ntshav hypotension, oliguria thiab hyperkalemia. Thaum oliguria zoo nkaus li, ntshav siab thiab lub raum ntshav zoo yuav tsum tswj hwm.

Cov tshuaj Hinapril-SZ yuav tsum tsis txhob muab tshuaj rau lub sijhawm pub niam mis vim qhov tseeb tias ACE inhibitors, suav nrog hinapril, nkag mus rau hauv niam cov kua mis kom tsawg. Muab qhov ua tau los ntawm qhov muaj qhov tsis zoo tshwm sim hauv cov menyuam mos, cov tshuaj Hinapril-SZ yuav tsum tau muab tshem tawm thaum lub sijhawm lactation lossis txwv tsis pub niam mis.

Daim ntawv tso tawm

Cov ntsiav tshuaj ua yeeb yaj kiab, 5 mg, 10 mg, 20 mg, 40 mg. 10 lossis 30 ntsiav tshuaj. nyob rau hauv sawv hlwv sawb ntim. 30 ntsiav tshuaj nyob rau hauv lub thawv polymer lossis hauv lub raj mis polymer. Ib lub hwj lossis ib lub raj mis, 3, 6 blister ntim ntawm 10 ntsiav tshuaj. lossis 1, 2 blister pob ntawm 30 ntsiav tshuaj. muab tso rau hauv lub thawv ntawv thawv.