Dosage daim ntawv ntawm Januvia - zaj duab xis-coated ntsiav tshuaj: biconvex, puag ncig, ntawm ib koob tshuaj ntawm 25 mg - lub teeb liab nrog lub teeb beige tint thiab engraving "221", ntawm ib koob tshuaj ntawm 50 mg - lub teeb beige, nrog engraving "112", ntawm ib koob tshuaj ntawm 100 mg - beige, nrog engraving "277" (14 pcs. hauv hlwv, hauv ib pob ntawv qhwv ntawm 1, 2, 4, 6 lossis 7 hlwv).

Muaj pes tsawg leeg ib 1 ntsiav tshuaj:

• cov tshuaj nquag: sitagliptin phosphate hydrate - 32.13 / 64.25 / 128.5 mg (uas yog sib npaug nrog cov ntsiab lus ntawm sitagliptin - 25/50/100 mg),
• Cov khoom ua haujlwm pabcuam: microcrystalline cellulose, tsis muaj teeb meem calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate, sodium stearyl fumarate,
• zaj duab xis txheej: ntawm ib koob tshuaj 25 mg - Opadrai II Paj Yeeb 85 F 97191, ntawm koob tshuaj 50 mg - Opadrai II Lub teeb beige 85 F 17498, ntawm koob tshuaj 100 mg - Opadrai II Beige 85 F 17438 (polyvinyl cawv, titanium dioxide, polyethylene glycol 3350, talc, hlau oxide daj, hlau oxide liab).

Cov Tshuaj Hauv Tshuaj

Lub cev sib xyaw ua ke ntawm Januvia yog sitagliptin, uas muaj kev xaiv tshwj xeeb rau lub zog enzyme DPP-4 (dipeptidyl peptidase-4), npaj rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus. Hais txog kev teeb tsa tshuaj lom neeg thiab cov chaw muag tshuaj, sitagliptin txawv ntawm GLP-1 analogues (glucagon-zoo li peptide-1), sulfonylurea derivatives, insulin, biguanides, γ-receptor agonists (ua haujlwm los ntawm peroxisome proliferator - PPAR-γ), α-glycosidase inhibitors, analogues amylin. Sitagliptin, inhibiting DPP-4, yog li ua rau muaj kev nkag siab ntau ntawm GLP-1 thiab HIP (glucose-dependant insulinotropic peptide) - ob txoj kev paub cov tshuaj hormones uas yog ib feem ntawm tsev neeg incretin, uas tau muab zais rau hauv txoj hnyuv rau 24 teev, thiab qib uas nce ntxiv hauv kev teb rau kev noj zaub mov. Cov incretins yog ib feem ntawm cov kev tawm dag zog hauv lub cev ua haujlwm rau kev tswj ntshav qabzib homeostasis, lawv pab txhawb cov tshuaj tua kab mob insulin thiab nws qhov zais cia los ntawm pancreatic cells-hlwb vim cov paib ua cim rau intracellular cov kab mob ntsig txog cyclic AMP (adenosine monophosphate), nrog lub cev lossis nce ntshav ntxiv.

GLP-1 inhibits qhov tso zis ntau dua ntawm glucagon los ntawm α-hlwb ntawm cov txiav. Kev poob qis hauv cov qib glucagon tiv thaiv keeb kwm yav dhau los ntawm kev nce ntxiv hauv cov kua dej hauv cov tshuaj insulin tsim cov kua nplaum los ntawm lub siab, uas ua rau glycemia txo qis.

Thaum tsis muaj cov ntshav qabzib tsawg, cov nyhuv ntawm incretins ntawm insulin synthesis thiab glucagon tso zis tsis pom, lawv tsis cuam tshuam rau qhov kev tso tawm ntawm glucagon nyob rau hauv teb rau hypoglycemia. Hauv vivo, DPP-4 enzyme txwv cov kev ua ntawm incretins, sai sai hydrolyzing lawv thiab decomposing lawv mus rau hauv cov khoom siv tsis tau.

Sitagliptin, inhibiting cov hauj lwm zoo ntawm DPP-4, yog li tiv thaiv cov hydrolysis ntawm incretins, nce ntshav ntau ntxiv ntawm cov nquag cov ntaub ntawv ntawm GLP-1 thiab HIP, uas ua rau cov ntshav qabzib tso tawm ntawm insulin thiab pab txo cov kua ntshav ntawm glucagon. Ntawm hom 2 mob ntshav qab zib mellitus nrog hyperglycemia, xws li kev kho qhov tseeb ntawm cov kua dej ntawm cov kua dej thiab glucagon ua rau muaj qhov txo qis ntawm cov tshuaj HbA1c (glycosylated hemoglobin) thiab txo qis hauv qib ntawm cov piam thaj tau txiav txim siab ntawm ob lub plab thiab tom qab kev ntsuam xyuas kev ntxhov siab.

Noj ib zaug xwb ntawm Januvia nrog hom 2 mob ntshav qab zib ua rau inhibition ntawm DPP-4 enzyme rau 24 teev, raws li qhov uas cov qib ntawm cov ntshav nce zuj zus GLP-1 thiab HIP nce li 2-3 zaug, lub plasma concentration ntawm insulin thiab C-peptide nce, thiab txo qis plasma glucagon concentration, yoo mov glycemia thiab tom qab cov zaub mov thauj khoom noj lossis ntshav qabzib load yog txo.

Cov Tshuaj Pharmacokinetics

Lub zog txoj cai ntawm kev siv tshuaj lom neeg thiab cov txheej txheem lom neeg uas tshwm sim nrog sitagliptin hauv lub cev ntawm cov tib neeg muaj kev noj qab haus huv thiab cov neeg mob uas muaj ntshav qab zib hom 2 tau raug tshawb fawb kom nkag siab. Cov yam ntxwv rau cov neeg tuaj yeem noj qab haus huv tom qab kev tswj hwm qhov ncauj ntawm 100 mg ntawm sitagliptin: nqus - ceev ceev, tus nqi TC_max (lub sijhawm kom txog qhov siab tshaj plaws) - 1–4 teev txij li lub sijhawm saib xyuas, AUC (thaj chaw hauv qab "nkhaus-sijhawm" nkhaus) - 8.52 μmol / teev, qhov ntsuas no yog sib npaug rau cov koob tshuaj, C_max - 950 nmol / L, T_1/2 (nruab nrab ib nrab-lub neej) - 12.4 teev .Qhov AUC ntawm sitagliptin tom qab kev noj tshuaj ntxiv 100 mg ntawm cov tshuaj tom qab ncav lub sib luag hauv xeev tom qab noj thawj koob tshuaj nce los ntawm

14% Nyob rau hauv- thiab kev sib tshuam ntawm AUC yog qhov tsis lees paub.

Pharmacokinetic cov yam ntxwv ntawm Januvia:

kev nqus: qhov taw qhia ntawm cov tsis muaj peev xwm tiag tiag ntawm sitagliptin yog

87%, kev sib koom tes ntawm cov tshuaj nrog cov khoom noj muaj roj tsis muaj kev cuam tshuam nws cov pharmacokinetics, kev faib tawm: tom qab ib koob tshuaj ib zaug hauv 100 koob tshuaj, qhov nruab nrab ntim ntawm sitagliptin hauv kev sib npaug hauv cov ntsiab lus noj qab haus huv yog.

198 l. Lub plasma protein binding feem yog tus tsawg (

38%), cov metabolism: txog li 79% ntawm sitagliptin yog tshem tawm los ntawm lub raum tsis hloov, tsuas yog ib feem me me ntawm cov tshuaj uas tau noj yog metabolized tom qab 14 C-daim ntawv lo sitlliptin yog noj

16% ntawm cov tshuaj yeeb yaj kiab tau nthuav tawm hauv daim ntawv ntawm cov tshuaj metabolites, 6 metabolites ntawm sitagliptin tau pom nyob rau hauv cov nyiaj kab, feem ntau yuav tsis muaj DPP-4 inhibitory nyhuv, zam kev: tom qab 14 C-daim ntawv sitagliptin raug tswj hwm rau kev noj qab haus huv, txog li 100% ntawm cov tshuaj tau tawm hauv ib lub lis piam txij lub sijhawm ntawm cov thawj coj raws li hauv qab no: dhau los ntawm txoj hnyuv - 13%, ob lub raum - 87%. T_1/2 thaum noj ntawm qhov ncauj ntawm ib koob 100 mg

12.4 h, lub raum tshem tawm

Kev ntsuas rau siv

• monotherapy: cov neeg mob uas ua raws kev noj haus tshwj xeeb thiab tau txais kev tawm dag zog yog cov tshuaj uas txhim kho glycemic tswj nyob rau hauv hom 2 mob ntshav qab zib,
• kev sib xyaw ua ke: kev sib xyaw nrog metformin lossis PPARγ receptor agonists (thiazolidinediones) raug kho rau cov neeg mob uas muaj ntshav qab zib hom 2 ntshav txhawm rau txhawm rau txhim kho glycemic tswj, nyob rau hauv cov ntaub ntawv ntawm kev noj zaub mov tsis ua hauj lwm thiab kev tawm dag zog hauv kev sib xyaw nrog kev kho mob monotherapy.

Cov Yuav Tsum Muaj

• ntshav qab zib hom 1
• mob ketoacidosis,
• lub caij nyoog ntawm cev xeeb tub thiab lactation (lactation),
• cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo,
• muaj qhov tsis haum xeeb rau ib qho twg ntawm cov yeeb tshuaj.

Tus neeg txheeb ze contraindications: Januvia yuav tsum tau ua nrog ceev faj hauv lub raum tsis ua haujlwm. Cov neeg mob uas mob raum thiab lub raum tsis ua hauj lwm thiab lub raum pathology hauv lub davhlau ya nyob twg xav tau hemodialysis yuav tsum tau txhaj tshuaj ntawm sitagliptin.

Cov lus qhia rau kev siv Januvia: txoj kev thiab ntau npaum li cas

Januvia ntsiav tshuaj noj ntawm qhov ncauj, tsis hais txog ntawm cov pluas noj.

Cov koob tshuaj pom zoo rau kev kho mob monotherapy, nrog rau kev sib xyaw nrog metformin lossis PPARγ agonist (thiazolidinediones), yog 100 mg ib hnub ib zaug.

Yog hais tias tus neeg mob tsis nco qab noj tshuaj ntxiv, nws yuav tsum noj sai li sai tau, sai li sai tau tom qab nws nco qab txog kev hla lub koob tshuaj, tab sis tsis pub txais tos ntawm ob koob.

Sab sij huam

Januvia raws li kev kho mob monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic feem ntau zoo tiv thaiv. Lub sijhawm tag nrho ntawm qhov tshwm sim tsis zoo, nrog rau lub sijhawm ntawm kev tshem tawm ntawm sitagliptin vim tsis muaj qhov cuam tshuam, raws li kev tshawb fawb soj ntsuam, tau zoo ib yam li cov kaw raws li kev noj tshuaj.

Cov xwm txheej tsis zoo uas tsis muaj kev sib txuas nrog kev siv cov tshuaj sitagliptin hauv ib hnub ntawm 100 thiab 200 mg, tab sis ntau dua li cov neeg mob uas tau txais cov placebo (≥ 3% ntawm cov mob): sab sauv ntawm txoj hlab pa, nasopharyngitis, mob taub hau, raws plab, mob pob txha.

Lwm qhov kev phiv rau Januvia:

• GI mob hnyuv (lub plab zom mov): mob plab, xeev siab, ntuav, raws plab,
• cov ntaub ntawv hauv chav kuaj mob (tsis suav tias yog kev kho mob tseem ceeb): qhov nce ntawm uric acid (tsis muaj gout tau sau cia), qhov kev poob qis me ntsis ntawm cov xoos ntawm tag nrho cov alkaline phosphatase, qee qhov cuam tshuam nrog txo me me ntawm cov pob txha feem ntawm alkaline phosphatase, nce me ntsis ntawm cov ntsiab lus ntawm leukocytes vim muaj qhov nce ntawm neutrophils (tshwm sim sau tseg nyob rau hauv feem ntau cov kev tshawb fawb, tab sis tsis yog txhua yam)
• kev mob plawv: thaj chaw kho mob tau hloov pauv tseem ceeb hauv cov paib tseem ceeb thiab electrocardiograms (ECG), suav nrog QTc ncua sijhawm, tsis pom.

Noj ntau dhau

Cov kev tshawb fawb soj ntsuam nrog cov neeg ua haujlwm noj qab haus huv tau pom tias sitagliptin nyob rau hauv ib koob ntawm 800 mg feem ntau pom zoo zoo. Hauv ib kis, qhov kho mob tsawg tsawg hauv kev kho mob me me hauv QTc lub sijhawm. Qhov kev noj tshuaj ntawm cov tshuaj txhua hnub hauv kev tshaj 800 mg rau hauv tib neeg tsis tau kawm.

Yog tias muaj kev noj ntau dhau, nws raug nquahu kom siv cov qauv kev txhawb nqa: tshem tawm cov tshuaj tsis raug tshem tawm los ntawm lub plab zom mov, kev tshuaj xyuas tas li ntawm cov cim tseem ceeb, suav nrog ECG, nrog rau kev teem sijhawm kho mob yog tias tsim nyog.

Cov tshuaj tsis zoo txaus rau lub cev (rau 3-4 teev ntawm kev hloov kho ntu ib teev, raws li kev soj ntsuam, tsuas yog 13,5% ntawm cov koob tshuaj yog tawm ntawm lub cev). Nrog rau cov ntaub ntawv pov thawj xav tau, kev lim ntshav ntev ntev tuaj yeem kho tau. Tam sim no tsis muaj ntaub ntawv qhia txog kev ua haujlwm ntawm kev tshem tawm sitagliptin thaum lub sijhawm cov ntshav tawm peritoneal.

Cov lus qhia tshwj xeeb

Raws li kev tshawb fawb soj ntsuam, qhov tshwm sim ntawm kev noj tshuaj Januvia ua ib qho kev kho tshuaj lossis ua ib feem ntawm txoj kev kho mob nyuaj nrog tshuaj metformin / pioglitazone, hypoglycemia tsim rau hauv cov neeg mob uas muaj ntau zaus zoo ib yam li ntawd nrog tshuaj placebo.

Kev siv tshuaj sib xyaw ua ke nrog cov tshuaj uas tuaj yeem ua rau mob ntshav qab zib, piv txwv li, nrog insulin lossis sulfonylurea derivatives, tsis tau kawm.

Cev xeeb tub thiab lactation

Vim tias tsis muaj cov ntaub ntawv los ntawm kev tshawb fawb soj ntsuam txog kev nyab xeeb thiab muaj txiaj ntsig ntawm cov tshuaj hauv cov poj niam cev xeeb tub, Januvius, zoo li lwm yam kab mob hypoglycemic rau kev tswj hwm qhov ncauj, tsis pom zoo rau siv thaum cev xeeb tub.

Tsis muaj ntaub ntawv qhia txog kev tso cai ntawm sitagliptin thaum lactation, yog li cov tshuaj tsis raug txwv thaum ua niam mis.

Nrog lub raum tsis ua haujlwm

Cov neeg mob raum tsis txaus yuav tsum tau txhaj tshuaj los kho Januvia, uas nws pom zoo tias qhov kev ntsuas ntawm lub raum ua haujlwm ua ntej pib qhov kawg thiab tom qab ntawd rov ua ntu zus los ntawm txoj kev kho.

Cov koob tshuaj hloov kho nyob ntawm qhov ntsuas ntawm lub raum tsis ua hauj lwm thiab cov kev tshem tawm zoo (QC):

• lub raum tsis ua haujlwm tsawg, CC> 50 ml / min (ntshiab si creatinine concentration: hauv cov txiv neej - tsawg dua 1.7 mg / dl, hauv cov poj niam - tsawg dua 1.5 mg / dl): tsis tas yuav tsum kho dua,
• mob raum tsis txaus, CC los ntawm 30 txog 50 ml / min (ntshav creatinine concentration: hauv txiv neej - 1.7–3 mg / dl, rau cov poj niam - 1.5-2.5 mg / dl): koob tshuaj txhua hnub - 50 mg hauv 1 koob tshuaj
• mob raum tsis zoo, QC

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Cov kws tshawb fawb los ntawm University of Oxford tshawb nrhiav ntau qhov kev tshawb fawb, thaum lub sijhawm lawv tau txiav txim siab tias kev tsis noj zaub ua rau muaj kev phom sij rau tib neeg lub hlwb, vim tias nws ua rau nws qhov tsawg. Yog li cov kws tshawb fawb pom zoo kom tsis txhob cais cov ntses thiab nqaij los ntawm lawv cov kev noj haus.

Yog tias koj poob los ntawm tus nees luav, koj nyiam yob koj lub caj dab ntau dua li yog koj ntog los ntawm nees. Tsuas tsis sim rau refute nqe lus no.

Muaj ntau cov kev kho mob nthuav tawm heev, xws li kev siv khoom tsis nco qab ntawm cov khoom. Hauv plab ntawm ib tus neeg mob uas tau mob los ntawm tus txiv neej no, 2500 cov khoom txawv teb chaws tau pom.

Tib neeg cov ntshav "khiav" los ntawm cov hlab ntsha hauv qab qhov siab, thiab yog tias nws txoj kev ncaj ncees tau ua txhaum, nws tuaj yeem tua txog 10 meters.

Qhov kub siab tshaj plaws ntawm lub cev tau sau cia ntawm Willie Jones (USA), uas tau nkag rau hauv tsev kho mob nrog qhov kub txog 46,5 ° C.

Thaum cov neeg nyiam hnia, lawv ib leeg poob 6.4 kcal ib feeb, tab sis tib lub sijhawm lawv sib pauv yuav luag 300 ntau hom kab sib txawv.

Qhov ua kom pom kev vibrator ua ntej nyob rau xyoo 19th. Nws ua haujlwm ntawm lub tshuab tso hluav taws xob thiab nws tau npaj kho qhov mob poj niam.

Hauv kev mob siab kom tau tus neeg mob tawm, cov kws kho mob feem ntau mus deb dhau. Yog li, piv txwv li, qee yam Charles Jensen nyob rau lub sijhawm txij xyoo 1954 txog 1994. muaj sia nyob ntau dua 900 lub neoplasm tshem tawm txoj haujlwm.

Txhua tus neeg muaj tsis tsuas yog nyias tus ntiv tes, tab sis kuj hais lus.

Tib neeg cov pob txha yog plaub zaug muaj zog dua li cov pob zeb.

Cov tib neeg uas tau noj tshais ua ntu zus feem ntau yog cov muaj rog.

Hauv tebchaws Askiv, muaj txoj cai lij choj raws li uas tus kws phais neeg tuaj yeem tsis kam ua haujlwm rau tus neeg mob yog tias nws haus luam yeeb lossis rog dhau. Ib tus neeg yuav tsum tso tawm tus cwj pwm tsis zoo, thiab tom qab ntawd, tej zaum, nws yuav tsis xav tau kev phais mob.

Caries yog hom kis tau yooj yim tshaj plaws hauv ntiaj teb uas txawm tias tus mob npaws tsis tuaj yeem sib tw nrog.

Hauv 5% ntawm cov neeg mob, antidepressant clomipramine ua rau lub orgasm.

Tus mob uas tsis tshua muaj mob yog Kuru's kab mob. Tsuas yog cov neeg sawv cev ntawm pawg neeg Fore hauv New Guinea mob nrog nws. Tus neeg mob tuag ntawm kev luag. Nws ntseeg tau tias qhov ua rau tus mob yog noj tib neeg lub hlwb.

Tus naj npawb ntawm cov neeg ua haujlwm hauv chaw ua haujlwm tau nce siab hauv lub cev. Cov qauv no yog tshwj xeeb tshaj yog cov yam ntxwv ntawm cov nroog loj. Kev ua haujlwm hauv chaw ua haujlwm nyiam cov txiv neej thiab poj niam.

Cov lus qhia rau kev siv Januvia, ntau npaum li cas

Cov tshuaj no tau noj tsis hais txog pluas noj. Yog tias ploj ntawm cov tshuaj yuav tsum tau ua sai li sai tau. Kev siv cov koob txhaj tshuaj ob zaug yog qhov tsis lees txais tau.

Cov lus qhia pom zoo rau kev siv Januvia ntau npaum li cas ntawm kev kho mob, nrog rau kev sib xyaw nrog metformin lossis PPARγ agonist (thiazolidinediones) - 1 ntsiav tshuaj 100 mg 1 lub sijhawm ib hnub.

Nrog CC - 30-50 ml / feeb, ntshav creatinine 1.7-3 mg / dl (rau txiv neej), 1.5-2.5 mg / dl (rau cov poj niam), qhov koob tshuaj yog txo mus rau 50 mg 1 lub sij hawm ib hnub.

Nrog CC tsawg dua 30 ml / min, ntshav creatinine ntau dua 3 mg / dl (hauv cov txiv neej) thiab ntau dua 2.5 mg / dl (hauv cov poj niam), zoo li rau cov neeg mob hauv lub davhlau ya nyob twg ntawm kev mob raum tsis ua haujlwm uas yuav tsum tau muaj mob hemodialysis, koob tshuaj yog 25 mg ib hnub (tsis hais lub sijhawm ntawm hemodialysis).

Cov lus qhia tshwj xeeb

Thaum lub sijhawm sim tshuaj ntawm cov tshuaj, qhov tshwm sim ntawm kev mob ntshav qab zib thaum lub sijhawm nws siv zoo ib yam li cov placebo.

Cov neeg mob uas tau them nyiaj tiv thaiv hepatic tsis txaus yuav tsum tsis hloov pauv ntau npaum li cas ntawm cov tshuaj.

Sab sij huam

Cov kev qhia ceeb toom ceeb toom txog qhov ua tau ntawm kev txhim kho cov kev mob tshwm sim hauv qab no thaum muab tshuaj Januvius:

• Kab mob ntsws, nasopharyngitis.
• Mob taub hau.
• Mob plab, mob plab, ntuav, xeev siab.
• Pob Tsuas Xyooj.
• Kev ntshav siab.
• Cov ntaub ntawv kuaj pom: ib qho kev nce hauv cov ntsiab lus ntawm uric acid, qhov kev poob qis me ntsis hauv kev tsuam ntxiv ntawm alkaline phosphatase, nce ntxiv ntawm neutrophils.

Cov Yuav Tsum Muaj

Nws yog contraindicated rau tshuaj Januvius nyob rau hauv cov nram no:

• Yam 1 ntshav qab zib
• Cev xeeb tub thiab lactation
• Ntshav qab zib ketoacidosis
• Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj,
• Lub hnub nyoog txog 18 xyoo.

Sau ntawv nrog kev ceev faj:

Noj ntau dhau

Nyob rau hauv rooj plaub ntawm overdose, lub plawv dhia tuaj yeem hloov pauv.

Yog tias pom muaj cov kev mob tshwm sim los yog lwm cov tsos mob tshwm sim, nws yuav tsum tau sab laj nrog koj tus kws kho mob kom pab kho raws sijhawm.

Cov qauv ntawm Januvius, tus nqi hauv cov chaw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Januvia ntsiav tshuaj nrog ib qho analogue ntawm cov tshuaj nquag lossis kho cov nyhuv - cov no yog cov tshuaj:

Thaum xaiv cov tshuaj analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Januvia, nqi thiab tshuaj xyuas tsis siv rau cov tshuaj uas muaj cov nyhuv zoo sib xws. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Nqe nyob rau hauv cov chaw muag tshuaj Lavxias: Januvia 100 mg 28 ntsiav tshuaj - los ntawm 1570 txog 1699 rubles, raws li 703 lub tsev muag tshuaj.

Khaws ntawm 30 ° C. Khaws tsis ncav cuag ntawm cov menyuam yaus. Txee lub neej yog 2 xyoos.

Kev siv tshuaj tiv thaiv hypoglycemic Januvia - cov lus qhia rau kev siv

Tshuaj kho mob ntshav qab zib muaj ntau yam sib txawv. Cov no suav nrog cov tshuaj Januvia.

Kev ua tiav ntawm kev kho mob nrog nws yog nyob ntawm kev ua raws li cov lus qhia, yog li koj yuav tsum paub dab tsi nws cov kev cai yooj yim.

Cov khoom no yog tsim tawm hauv Netherlands. Nws yog ib ntsiav tshuaj nrog hypoglycemic nyhuv, tsim ntawm lub hauv paus ntawm Sitagliptin. Cov tshuaj tuaj yeem xaj tuaj yeem hauv lub hwj tshuaj.

Kev Sau ua ke, daim foos tso tawm

Cov tshuaj tivthaiv tseem ceeb ntawm cov tshuaj yog sitagliptin. Nws yog nws qhov kev ua uas ua rau cov tshuaj no ua rau muaj ntshav qab zib. Hauv cov khw muag tshuaj koj tuaj yeem pom ob peb ntau yam ntawm cov nyiaj - raws li tus nqi ntawm cov tshuaj yeeb dej caw. Tej zaum nws yuav muaj 25, 50 thiab 100 mg.

Cov khoom xyaw pabcuam hauv qab no ntxiv rau nws:

• sodium stearyl fumarate,
• calcium hydrogen phosphate,
• microcrystalline cellulose,
• croscarmellose sodium,
• magnesium stereate,
• macrogol
• titanium dioxide
• talcum hmoov.

Cov ntsiav tshuaj hloov puag ncig, biconvex. Lawv cov xim yog beige, txhua tus engraved nrog "277". Lawv muab tso rau hauv pob contour hauv qhov nyiaj ntawm 14 pcs. Ib daim npav cardboard tej zaum yuav muaj ntau lub pob (2-7).

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Cov nyhuv ntawm cov tshuaj ntawm lub cev yog vim muaj cov yam ntxwv ntawm nws txoj kev nquag. Sitagliptin (cov qauv hauv daim duab) ua rau muaj kev tsim tawm los ntawm cov kua dej los ntawm cov txiav, vim tias cov piam thaj hauv lub cev tau faib ntau dua sai sai hauv cov ntaub so ntswg.

Ib qho kev nce ntawm cov nqi ntawm cov tshuaj insulin cuam tshuam rau daim siab, tiv thaiv nws los ntawm kev tsim cov piam thaj ntau dhau. Qhov no muab qhov txo qis hauv kev mloog zoo ntawm cov piam thaj hauv cov ntshav qab zib thiab ua kom nws txoj kev noj qab haus huv zoo.

Kev nqus ntawm cov khoom nquag tshwm sim sai heev. Qhov kev tiv thaiv no ncav cuag nws cov txiaj ntsig zoo tshaj plaws txog ib teev tom qab siv Januvia thiab kav ntev dua 3 teev. Ntxiv mus, cov tshuaj pib maj mam tshem tawm ntawm lub cev, thiab nws cov nyhuv yog qhov ua kom tsis muaj zog.

Kev sib txuas lus nrog ntshav protein ua ib qho me me ntawm sitagliptin. Nrog cov metabolism, qhov feem yuav luag hloov pauv tsis tau. Kev zam ntawm qhov tseem ceeb ntawm nws yog ua los ntawm lub raum. Qhov seem tshuav yog tshem tawm nrog quav.

Kev taw qhia thiab contraindications

Raws li cov lus qhia, cov tshuaj no pab nrog hom ntshav qab zib hom 2. Nws tuaj yeem siv nrog lwm cov tshuaj los yog raws li kev kho mob monotherapy, uas tau ntxiv nrog kev noj zaub mov noj.

Tab sis qhov kev kuaj pom no tsis txhais tau tias koj yuav tsum pib siv cov tshuaj no tam sim ntawd. Cov tshuaj yuav tsum yog tus kws kho mob sau tseg tom qab kev tshuaj xyuas thiab piav qhia hauv kev nthuav dav cov cai ntawm kev siv. Qhov no tseem ceeb vim tias Januvia muaj contraindications, uas tuaj yeem ua rau nws siv phom sij.

Ntawm lawv hais txog:

• ketoacidosis uas muaj keeb kwm mob ntshav qab zib,
• ntshav qab zib hom 1
• intolerance rau lub composition,
• cov menyuam yaus thiab cov hluas,
• cev xeeb tub
• lub sijhawm pub niam mis.

Kuj tseem muaj cov xwm txheej uas cov khoom lag luam tuaj yeem siv, tab sis yuav tsum ceev faj. Feem ntau, kev ntsuas tshwj xeeb yog npaj rau cov neeg mob uas muaj lub raum tsis hnyav.

Tus kws kho mob tshwj xeeb tuaj yeem muab tshuaj Januvia rau lawv, tab sis nws yuav tsum yog lub luag haujlwm rau kev xaiv qhov ntau thiab tsawg cov tshuaj. Ib qho ntxiv, koj yuav tsum tau saib xyuas kev ua haujlwm ntawm lub raum txhua lub sijhawm.

Cov neeg mob tshwj xeeb

Txog qee tus neeg mob, nws tsis yog qhov zoo uas yuav tau siv cov cai siv tshuaj thoob plaws. Lawv muaj hom tshwj xeeb. Cov neeg sawv cev ntawm qee pab pawg tsis tso cai kom tau txais Januvia; kev saib xyuas tshwj xeeb yuav tsum muaj kev sib raug zoo nrog lwm tus.

1. Cov poj niam cev xeeb tub. Tsis muaj xov xwm cuam tshuam txog cov nyhuv ntawm cov tshuaj rau cov neeg mob zoo li no, txij li kev tshawb fawb hauv thaj chaw no tsis tau ua. Txhawm rau zam kev pheej hmoo txaus ntshai, muaj ntshav qab zib rau cov poj niam cev xeeb tub, cov kws kho mob sau ntawv rau lwm cov tshuaj.
2. Saib xyuas niam cov txiv. Kuj tsis paub meej tias cov khoom xyaw nquag nkag mus rau niam mis. Hauv qhov no, nws nyuaj rau tshawb nrhiav seb cov tshuaj no cuam tshuam rau tus menyuam li cas. Raws li, nrog lactation, nws tsis tuaj yeem siv Januvia.
3. Menyuam yaus thiab tub ntxhais hluas. Cov lus qhia rau cov tshuaj tsis muab rau kev kho mob ntawm cov neeg mob hnub nyoog qis dua 18 xyoo. Yog li, mob ntshav qab zib hauv cov neeg mob no tau kho nrog lwm txoj hauv kev.
4. Neeg laus. Sitagliptin tsis suav hais tias yog txaus ntshai rau cov neeg hauv pawg no. Thaum tsis muaj teeb meem kev noj qab haus huv, cov sij hawm ib txwm rau kev noj tshuaj tau raug tso cai, txawm tias muaj lub hnub nyoog hloov hauv lub cev. Tab sis kws kho mob yuav tsum tau saib xyuas chav kawm ntawm txoj kev kho mob tshwj xeeb kom ceev faj.

Hauv txhua lwm yam mob, tso siab rau kev soj ntsuam daim duab ntawm tus kab mob thiab cov yam ntxwv ntawm lub cev.

Kev sib cuam tshuam txog Yeeb Tshuaj thiab Analogs

Yog hais tias tus neeg mob tsis muaj ntshav qab zib nkaus xwb, tom qab ntawv kho nws yuav tsum muaj kev saib xyuas tshwj xeeb. Tsis yog txhua yam tshuaj tuaj yeem sib xyaw ua ke nrog lwm tus, qee zaum kev sib xyaw ua ke ntawm qee yam tshuaj yuav ua rau muaj kev cuam tshuam ntawm lawv cov kev ua.

Januvia pom tias muaj kev nyab xeeb hauv qhov no, txij li lwm cov tshuaj muaj cov cuam tshuam tsawg rau nws.

Hloov pauv me me hauv nws cov hauj lwm zoo yuav tshwm sim nrog kev siv cov tshuaj no ib txwm nrog digoxin thiab cyclosporine. Nyob ntawm seb yuav hais li cas rau cov kev hloov no, noj rau xaiv.

Vim tias cov tshuaj no kim, cov neeg mob feem ntau tau hais kom muab lawv cov tshuaj zoo dua.

Cov kws tshaj lij xaiv lawv los ntawm cov txhais tau tias hauv qab no:

Txhua tus kws kho mob yuav tsum sau ntawv rau ib qho ntawm cov tshuaj no tom qab tshuaj xyuas tus neeg mob. Txwv tsis pub, txoj kev loj hlob ntawm cov teeb meem tuaj yeem ua rau npau taws. Nws tseem yog ib qho tseem ceeb kom ua raws li cov cai rau kev xa tus neeg mob los ntawm ib hom tshuaj mus rau lwm tus.

Cov tswv yim ntawm cov kws kho mob thiab cov neeg mob

Kev txiav txim los ntawm kev txheeb xyuas, cov kws kho mob tsis tshua muaj tshuaj Januvia feem ntau vim tias tus nqi siab ntawm cov tshuaj. Ntawm cov neeg mob, cov tshuaj kuj tsis nrov heev vim tias tus nqi siab thiab phiv cuam tshuam.

Kuv taw Januvius tsuas yog qee zaug. Qhov no yog yam tshuaj zoo uas ua rau cov ntshav qabzib qis. Tab sis nws kim heev, thiab cov neeg mob feem ntau tsis kam nws. Cov neeg uas muab nws dawb los yog ntawm tus nqi tshaj, tseem tsis txaus siab tas li, vim tias lawv muaj cov kev mob tshwm sim. Tam sim no, txuas ntxiv mus, tsuas yog ob ntawm kuv cov neeg mob siv cov tshuaj no. Nws phim rau lawv ntau dua li lwm cov tshuaj.

Elena Dmitrievna, tus kws kho mob

Siv cov tshuaj no tsuas yog ua tiav kev tshawb nrhiav qhov tseeb. Cov kev tiv thaiv tsis pom tseeb ua rau muaj kev rau txim loj, cov neeg mob tau txais kev mob tshwm sim, thiab cov txiaj ntsig yog xoom. Tab sis cov neeg uas qhov kev hais daws tau haum yog feem ntau txaus siab nrog lawv, lawv tsuas yog yws txog tus nqi siab. Txhua tus zuj zus.

Alexander Borisovich, kws kho mob

Kuv tsis coj Januvia ntev. Qhov kev hais daws yog qhov zoo, qab zib khaws cia ib txwm thiab tsis muaj kev phiv. Tab sis nws tseem kim heev, Kuv nyiam siv tus pheej yig dua.

Thaum xub thawj kuv xav tso cov tshuaj no. Kuv tau quaj los ntawm kev pw tsaug zog thiab lub zog tsis tu ncua vim pw tsaug zog tsis muaj. Qab zib rov qab zoo li qub, tab sis kuv xav tias phem heev. Thiab tom qab ntawd nws dhau - nws pom tseeb tias lub cev siv los ua nws. Tam sim no txhua yam haum rau kuv.

Tus nqi ntawm Januvia muaj kev cuam tshuam los ntawm kev xav txog ntawm cov tshuaj nquag thiab cov lej ntawm cov dej hauv pob. Rau cov ntawv ntim nrog koob tshuaj Sitagliptin hauv 100 mg (28 pcs.), Koj yuav tsum muab 2200-2700 rubles.