Yuav siv li cas Lorista ND rau cov ntshav qab zib

Cov khoom xyaw ua haujlwm ntawm Lorista yog losartan, uas muaj peev xwm los tiv thaiv angiotensin 2 lub zog hauv lub plawv, ob lub raum, cov hlab ntsha, thiab cov adrenal cortex, uas ua rau txo qis ntawm vasoconstriction (nqaim ntawm lub lumen ntawm cov hlab ntsha), txo qis ntawm tag nrho peripheral tsis kam thiab, vim li ntawd, kev txo ntshav siab.

Yog hais tias Lorista lub plawv tsis ua haujlwm, kev tshuaj xyuas pom tseeb tias nws ua rau muaj kev mob siab rau cov neeg mob lub cev, thiab tseem tiv thaiv kev txhim kho ntawm myocardial hypertrophy. Qhov siab tshaj plaws ntawm losartan nyob rau hauv cov ntshav tuaj yeem pom 1 teev tom qab qhov ncauj tswj hwm ntawm Lorista, thaum lub cev tsim tawm hauv lub siab pib ua haujlwm tom qab 2.5-4 teev.

Lorista N thiab Lorista ND yog kev sib txuam ntawm cov tshuaj, cov tshuaj yeeb dej caw uas yog losartan thiab hydrochlorothiazide. Hydrochlorothiazide muaj cov nyhuv diuretic, uas yog vim muaj peev xwm ntawm cov tshuaj los cuam tshuam cov txheej txheem ntawm cov theem ob ntawm kev tso zis, uas yog rov kho dej (nqus) ntawm dej, magnesium, potassium, chlorine, sodium ions, nrog rau kev ncua qhov tsis pom ntawm uric acid thiab calcium ions. Hydrochlorothiazide muaj cov cuab yeej hypotensive, uas tau piav qhia los ntawm nws cov kev ua tsom rau kev nthuav dav ntawm txoj hlab ntsha.

Cov nyhuv diuretic ntawm cov tshuaj no tuaj yeem pom hauv 1-2 teev tom qab kev thov ntawm Lorista N, thaum cov nyhuv hypotensive kev loj hlob hauv 3-4 hnub.

Kev taw qhia Lorista

Cov kev qhia tau pom zoo kom siv cov tshuaj Lorista thaum:

• leeg ntshav siab
• sab laug ventricular hypertrophy thiab leeg ntshav txhaws txhawm rau kom txo tau kev pheej hmoo ntawm mob hlab ntsha tawg,
• mob plawv tsis ua hauj lwm, yog ib feem ntawm txoj kev kho mob ua ke,
• nephrology nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus kom txo qis protenuria (muaj cov protein nyob hauv cov zis).

Raws li cov lus qhia, Lorista N tau kho yog tsim nyog, kev kho mob ua ke nrog tshuaj tiv thaiv ntshav thiab tshuaj kho ntshav.

Cov Yuav Tsum Tau Ua

Lorista, daim ntawv thov cuam tshuam nrog cov lus qhia ua ntej kho mob, tsis yog cov lus qhia txog ntshav qis, lub cev qhuav dej, hyperkalemia, lactose intolerance, tsis hnov ​​qab cov ntshav qab zib thiab galactose absorption syndrome, hypersensitivity to losartan. Koj yuav tsum tso tseg kev siv Lorista rau cov neeg cev xeeb tub thiab pub mis niam, nrog rau cov neeg muaj hnub nyoog qis dua 18 xyoo. Lorista N, ntxiv rau cov kev tiv thaiv saum toj saud, tsis yog kws kho mob rau lub raum lossis lub siab ua haujlwm thiab lub cev tsis ua haujlwm (tsis muaj zis nyob hauv lub zais zis).

Nrog ceev faj, Lorista ntsiav tshuaj yuav tsum tau noj rau cov neeg mob raum lossis hepatic tsis txaus, nrog lub cev tsis muaj dej-electrolyte tshuav, nrog cov ntshav tsawg ntawm cov ntshav ncig.

Cov lus qhia rau kev siv Lorista

Lorista muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj 100, 50, 25 lossis 12.5 mg ntawm potassium losartan. Cov tshuaj yuav tsum tau noj qhov ncauj ib zaug ib hnub.

Thaum muaj mob ntshav ntawm lub plawv, kom thiaj li txo cov kev pheej hmoo ntawm mob hlab ntsha tawg, ntxiv rau kev tiv thaiv lub raum hauv cov neeg mob ntshav qab zib mellitus, Lorista ntsiav tshuaj tau pom zoo kom coj Lorista ntsiav tshuaj txhua hnub ntawm 50 mg. Yog tias tsim nyog, txhawm rau ua kom tau txais ntau qhov txiaj ntsig, qhov koob tshuaj yuav raug nce rau 100 mg ib hnub twg. Raws li kev txheeb xyuas, Lorista nthuav dav nws cov nyhuv antihypertensive tsis pub dhau 3-6 lub lis piam ntawm kev kho mob. Nrog rau kev tswj hwm tib lub sij hawm ntawm kev txhaj tshuaj zoo ntawm diuretics, kev siv Lorista yuav tsum tau pib nrog 25 mg rau ib hnub. Tsis tas li, qis dua ntawm cov tshuaj yog pom zoo rau cov neeg uas muaj lub siab ua haujlwm tsis zoo.

Thaum muaj mob tsis txaus, cov tshuaj Lorista, daim ntawv thov cuam tshuam nrog kev tswj hwm tib txhij ntawm diuretics thiab mob plawv glycosides, nws siv raws li cov txheej txheem. Nyob rau thawj lub lim tiam ntawm kev kho mob, Lorista yuav tsum noj 12,5 mg rau ib hnub, tom qab ntawd txhua lub lim tiam koob tshuaj txhua hnub yuav tsum tau nce los ntawm 12,5 mg. Yog tias cov tshuaj noj raug cai, plaub lub lim tiam ntawm kev kho yuav pib nrog 50 mg ntawm Lorista ib hnub. Kev kho ntxiv nrog Lorista yuav tsum tau txuas ntxiv nrog kev tswj xyuas los ntawm 50 mg.

Lorista N yog ib ntsiav tshuaj muaj 50 mg ntawm losartan thiab 12.5 mg ntawm hydrochlorothiazide.

Lorista ND ntsiav tshuaj muaj tib qho kev sib txuam ntawm cov tshuaj, tsuas yog ob zaug ntau npaum - 100 mg ntawm losartan thiab 25 mg ntawm hydrochlorothiazide.

Nrog rau cov hlab ntshav siab, qhov xav kom zoo txhua hnub ntawm Lorista N yog 1 ntsiav tshuaj, yog tias tsim nyog, 2 ntsiav tshuaj ib hnub raug tso cai. Yog tias tus neeg mob tau txo qis hauv cov ntshav ntim, cov tshuaj yuav tsum pib nrog ib koob tshuaj 25 mg ib hnub twg. Lorista N ntsiav tshuaj yuav tsum tau noj tom qab kev kho ntawm cov ntim ntawm cov ntshav ncig thiab txoj kev tshem tawm ntawm diuretics.

Raws li kev txheeb xyuas, nws raug nquahu kom noj Lorista N ntawm qhov kev pheej hmoo ntawm cov kab mob plawv yog losartan monotherapy tsis tau pab kom ncav cuag lub hom phiaj ntawm kev mob ntshav siab. Cov koob tshuaj pom zoo ntawm cov tshuaj ib hnub yog 1-2 ntsiav tshuaj.

Sab sij huam

Cov kev mob tshwm sim ntawm Lorista ntsiav tshuaj thiab kev sim tshuaj suav nrog:

• mob taub hau, pw tsaug zog, qaug zog, kiv taub hau, asthenia, nco tsis meej, tshee, mob taub hau, mob siab,
• koob tshuaj hypotension, bradycardia, tachycardia, palpitations, angina pectoris, arrhythmia, vasculitis,
• mob ntsws, hnoos, mob ntsws, mob txhaws ntswg lossis o, ua tsis taus pa,
• mob plab, raws plab, xeev siab, lub qhov ncauj qhuav, tsis nco qab, mob plab, mob plab, ua kom tawv ncauj, ntuav, mob hniav, ua rau lub siab ua haujlwm tsis zoo, mob siab,
• mob txeeb zig, tso zis tsis tso zis, lub raum khiav tsis zoo, nce ntxiv cov kab mob creatinine thiab urea,
• poob qis txiv neej tsav, impotence,
• mob nrob qaum, ceg, hauv siab, mob plab, mob leeg mob, mob caj dab, mob pob txha,
• pom kev tsis sib xws, pom qhov tsis zoo, saj yam tsis nyiam, tinnitus,
• erythema (liab ntawm daim tawv nqaij, npau taws los ntawm nthuav tawm ntawm cov hlab ntsha), tawm hws, daim tawv nqaij qhuav, phytosensitization (nce rhiab rau ultraviolet hluav taws xob), ntau cov plaub hau hle,
• gout, hyperkalemia, anemia,
• angioedema, tawv nqaij sawv pob, khaus, urticaria.

Raws li txoj cai, cov tau teev tsis tsim kev xav ntawm cov tshuaj Lorista muaj lub sijhawm luv thiab tsis muaj zog.

Kev tshwm sim sab ntawm Lorista N yog nyob rau hauv ntau lub luag haujlwm zoo sib xws ntawm kev muaj sia ntawm kev muaj sia rau kev thov ntawm Lorista.

Cev xeeb tub thiab lactation

Epidemiological cov ntaub ntawv hais txog kev pheej hmoo ntawm teratogenicity thaum noj ACE inhibitors nyob rau thawj thawj lub hlis ntawm cev xeeb tub tsis tso cai thaum kawg xaus, tab sis me ntsis kev pheej hmoo tsis suav nrog. Txawm hais tias tsis muaj tseeb tswj cov ntaub ntawv hais txog teratogenicity ntawm ARA-I, cov kev pheej hmoo zoo sib xws tsis tuaj yeem cais tawm hauv pawg tshuaj no. Txawm hais tias nws tsis tuaj yeem hloov los hloov ARA-I nrog lwm txoj kev kho tshiab, cov neeg mob npaj lub cev xeeb tub yuav tsum tau hloov mus rau kev siv tshuaj, nyob rau hauv uas muaj kev nyab xeeb rau cov poj niam cev xeeb tub tau taub zoo. Thaum cev xeeb tub tshwm sim, ARA-Kuv yuav tsum nres tam sim ntawd, thiab yog tias tsim nyog, lwm txoj kev kho yuav tsum raug kho. Nrog rau kev siv ntawm ARA-I hauv kev txiav tawm hauv plab thib ob thiab thib peb ntawm cev xeeb tub, qhov tshwm sim ntawm cov nyhuv fetotoxic (kev ua haujlwm tsis zoo hauv lub raum, oligohydroamniosis, ncua ossification ntawm pob txha pob txha) thiab neonatal toxicity (lub raum tsis ua haujlwm, hypotension, hyperkalemia) tau tsim. Yog tias APA-II tau siv nyob rau hauv lub sijhawm thib ob lossis thib peb ntawm kev xeeb menyuam, nws raug nquahu kom ua qhov ntsuas ntawm lub raum thiab pob txha pob txha. Hauv cov menyuam mos uas lawv niam noj ARAL, nws yog qhov yuav tsum tau ua tib zoo saib xyuas ntshav siab txhawm rau tiv thaiv kev txhim kho kev mob ntshav siab.

Cov ntaub ntawv hais txog kev siv hydrochlorothiazide thaum cev xeeb tub muaj tsawg, tshwj xeeb yog rau thawj peb hlis. Hydrochlorothiazide hla lub tsho me me. Raws li kev siv tshuaj pharmacological ntawm kev ua, nws tuaj yeem sib cav tias nws siv hauv kev txiav thib ob thiab thib peb ntawm cev xeeb tub tuaj yeem cuam tshuam placental perfusion thiab ua rau muaj teeb meem hauv plab thiab menyuam mos, xws li mob daj ntseg, electrolyte tsis txaus thiab thrombocytopenia. Hydrochlorothiazide yuav tsum tsis txhob siv rau kev siv tes taw, kev tsis haum xeeb ntawm lub cev los yog mob toxicosis ntawm cev xeeb tub vim muaj kev pheej hmoo ntawm kev txo qis hauv cov ntshav ntim thiab kev txhim kho ntawm placental hypoperfusion thaum tsis muaj lub txiaj ntsig zoo ntawm chav kawm ntawm tus kab mob.

Hydrochlorothiazide yuav tsum tsis txhob siv los kho kev mob ntshav liab hauv cov poj niam cev xeeb tub, tsuas yog ntawm cov mob uas tsis tshua pom tshwm sim thaum kev mus rau lwm txoj kev kho tsis tuaj yeem ua tau.

Tsis muaj ntaub ntawv qhia txog kev siv tshuaj Lorista ND thaum lub sijhawm pub niam mis. Lwm txoj kev kho mob yuav tsum tau txiav txim siab nrog kev siv cov tshuaj uas muaj pov thawj zoo hauv kev nyab xeeb thaum lactation, tshwj xeeb tshaj yog thaum pub mis rau cov menyuam tshiab lossis cov menyuam mos ua ntej.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj no raug tso cai coj mus ua ke nrog lwm cov tshuaj tiv thaiv antihypertensive.

Cov tshuaj yuav noj tau yam tsis xav noj mov.

Cov ntsiav tshuaj yuav tsum tau muab ntxuav nrog ib khob ntawm dej.

Kev sib xyaw ntawm losartan thiab hydrochlorothiazide tsis yog npaj rau kev kho thaum xub thawj, kev siv yog pom zoo rau qee qhov tsis muaj kev tswj hwm txaus los ntawm ntshav txaus siv cais losartan thiab hydrochlorothiazide. Peb nqua hu kom txhaj cov koob tshuaj feem ntau. Yog tias tsim nyog kho hauv chav kho mob, nws raug nquahu kom xav txog kev hloov pauv ntawm kev kho mob monotherapy rau kev siv tshuaj sib xyaw nrog kev siv tshuaj.

Cov koob tshuaj saib xyuas li ib txwm yog 1 ntsiav tshuaj ntawm Lorista N (losartan 50 mg / hydrochlorothiazide 12.5 mg) ib hnub ib zaug.

Nrog rau cov lus teb tsis txaus siv tshuaj, koob tshuaj yuav raug nce ntxiv rau 1 ntsiav tshuaj ntawm Lorista ND (losartan 100 mg / hydrochlorothiazide 25 mg) ib hnub ib zaug. Qhov siab tshaj plaws yog 1 ntsiav tshuaj ntawm Lorista ND (losartan 100 mg / hydrochlorothiazide 25 mg) ib hnub.

Raws li txoj cai, cov nyhuv hypotensive tau tiav hauv 3-4 lub lis piam tom qab pib kho.

Siv rau qhov tsis zoo ntawm lub raum lub siab thiab hauv cov neeg mob ntawm hemodialysis Hauv cov neeg mob uas mob raum tsis ua haujlwm (kev tsim kho lub peev xwm ntawm 30-50 ml / min), qhov pib hloov kho tshuaj tsis tas yuav tsum. Nws tsis pom zoo kom sau ntawv tawm ua ke no rau kev qias neeg lub raum kev ua haujlwm tsis zoo (kev tsim muaj peev xwm muaj peev xwm muaj kev ntshiab.)

Noj ntau dhau

Cov Lus Qhia Tshwj Xeeb ntawm Kev Tshawb Fawb ntawm Losartan 50 mg / Hydrochlorothiazide Kev Sib Tham

12,5 mg tsis tuaj.

Txoj kev kho yog mob yam ntxwv, txhawb nqa.

Yog tias muaj kev noj ntau dhau, kev kho tshuaj yuav tsum tsis ua mus ntxiv, thiab tus neeg mob yuav tsum tau hloov chaw ntawm kev saib xyuas nruj. Yog tias cov tshuaj tau noj tsis ntev los no, nws raug nquahu kom ntxias mob ntuav, nrog rau kev siv cov hauv kev paub los ua cov txheej txheem tiv thaiv txhawm rau tshem tawm lub cev qhuav dej, electrolyte tsis txaus, hepatic coma thiab hypotension.

Cov ntaub ntawv ntau dhau raug txwv. Muaj peev xwm, feem ntau yuav muaj cov cim: hypotension, tachycardia, bradycardia (vim yog parasympathetic (vim yog ntawm qhov chaw mos) stimulation). Thaum cov tsos mob hypotension tshwm sim, kev kho tu yuav tsum kho.

Tsis yog losartan lossis nws lub zog metabolite tuaj yeem raug cais tawm los ntawm hemodialysis.

Cov kev qhia tshwm sim thiab cov tsos mob feem ntau, "hypokalemia, hypochloremia, hyponatremia (tshwm sim los ntawm cov ntshav electrolyte tsawg dua) thiab lub cev qhuav dej (vim yog diuresis ntau dhau.) Yog hais tias digitalis tau kho nyob rau tib lub sijhawm, hypokalemia tuaj yeem ua rau exacerbation ntawm lub plawv dhia tsis zoo.

Ntau npaum li cas hydrochlorothiazide yog raug tawm thaum lub sij hawm hemodialysis tsis paub.

Kev cuam tshuam nrog lwm yam tshuaj

Rifampicin thiab fluconazole txo qis qhov kev tswj hwm ntawm cov tshuaj metabolite. Cov kev mob tshwm sim los ntawm kev sib txuam no tsis tau kawm.

Xws li lwm yam tshuaj uas thaiv cov tshuaj angiotensin II lossis txo nws cov txiaj ntsig, kev siv cov tshuaj potassium-sparing diuretics (spironolactone, triamteren, amiloride), ntxiv rau cov tshuaj potassium ntxiv rau thiab ntxiv rau ntsev hloov tuaj yeem ua rau muaj kev nce siab ntxiv ntawm cov poov tshuaj hauv ntshav ntshav. Tsis tas siv qhov no los siv cov tshuaj no.

Zoo li lwm yam tshuaj uas cuam tshuam nrog sodium excretion, losartan tuaj yeem txo qhov kev tshem tawm ntawm lithium los ntawm lub cev. Yog li no, nrog tib lub sijhawm APA-II thiab kev siv cov roj ntsha lithium, ib qho yuav tsum ua tib zoo saib xyuas qib ntawm cov tom kawg hauv cov ntshav ntshav.

Nrog rau kev siv ua ke ntawm APA-II thiab tsis siv tshuaj tiv thaiv tsis haum tshuaj (NSAIDs) (piv txwv li, xaiv cyclooxygenase-2 inhibitors (COX-2), acetylsalicylic acid nyob rau hauv cov tshuaj tiv thaiv thiab tsis xaiv tshuaj (NSAIDs), kev tiv thaiv hypotensive yuav tsis muaj zog. Kev siv tshuaj ntxiv ntawm ARA-I lossis diuretics nrog NSAIDs tuaj yeem ua rau muaj kev pheej hmoo rau lub raum tsis ua haujlwm, suav nrog mob raum tsis ua haujlwm, thiab ua rau muaj qhov nce plasma potassium ntau dua (tshwj xeeb tshaj yog rau cov neeg mob uas muaj mob raum ua tsis muaj hlab plawv). Qhov kev sib xyaw no yuav tsum tau siv nrog ceev faj, tshwj xeeb tshaj yog rau cov neeg laus. Cov neeg mob yuav tsum tau txais qhov tsim nyog ntawm cov kua dej, yuav tsum txiav txim siab los saib xyuas qhov ua haujlwm tsis zoo ntawm lub raum tom qab pib kho cov mob thiab ua ntu zus thaum kho.

Hauv qee cov neeg mob uas lub raum tsis ua haujlwm, suav nrog. COX-2 inhibitors, kev siv cov tshuaj APA-II ntau ntxiv tuaj yeem ua rau kuv muaj qhov tsis zoo ntawm lub raum kev ua haujlwm. Txawm li cas los xij, cov nyhuv no feem ntau yuav thim rov qab.

Lwm yam tshuaj nrog cov nyhuv hypotensive yog tricyclic antidepressants, tshuaj tiv thaiv kev puas tsuaj, baclofen, thiab amifostine. Kev siv losartan nrog cov tshuaj no ua rau muaj kev pheej hmoo ntawm kev mob ntshav siab.

Nrog kev siv ua ke ntawm thiazide diuretics thiab cov tshuaj hauv qab no, kev cuam tshuam yuav raug soj ntsuam.

Ethanol, barbiturates, tshuaj muaj yees thiab cov tshuaj tiv thaiv kab mob.

Antidiabetic tshuaj (qhov ncauj thiab insulin)

Kev siv ntawm thiazides tuaj yeem cuam tshuam kev tso ntshav qabzib, vim tias kev hloov kho tshuaj ntawm cov tshuaj tiv thaiv kab mob ua kom tsim nyog. Metformin yuav tsum siv nrog ceev faj vim muaj kev pheej hmoo ntawm cov kab mob lactic acidosis los ntawm kev ua haujlwm lub raum tsis ua haujlwm cuam tshuam nrog kev siv hydrochlorothiazide.

Lwm cov tshuaj tiv thaiv antihypertensive Ntxiv cov nyhuv.

Cholestyramine thiab colestipol resins

Qhov nqus ntawm hydrochlorothiazide yog txo thaum raug rau anion txauv resins. Ib koob tshuaj cholestyramine los yog colestipol resins khi hydrochlorothiazide, txo nws qhov nqus mus rau hauv txoj hnyuv los ntawm 85% thiab 43%, feem. Corticosteroids, adrenocorticotropic hormone (ACTH)

Cov lus txo qis hauv kev saib xyuas ntawm electrolytes (tshwj xeeb, hypokalemia). Pressor amines (piv txwv li adrenaline)

Qhov kev ua kom tsis muaj zog rau cov tshuaj Pressers amines yog ua tau, uas, txawm li cas los xij, tsis txaus ntseeg los txwv lawv kev siv.

Skeletal leeg ua kom tsis txhob mob, tsis ua kom puas (xws li tubocurarine) Muaj peev xwm ua rau cov leeg to taub yooj yim dua.

Diuretics txo txoj kev ua kom lub ntsej muag kom zoo ntawm lithium thiab nce qhov kev pheej hmoo ntawm nws cov teebmeem lom. Kev tswj hwm tsis pom zoo.

Cov tshuaj siv los kho gout (probenecid, sulfinpyrazone thiab allopurinol)

Qhov kev hloov tshuaj ntawm cov tshuaj uas txhawb nqa cov tshuaj uric acid yuav tsim nyog, vim tias siv cov tshuaj hydrochlorothiazide tuaj yeem ua rau muaj qhov nce ntawm cov tshuaj uric acid hauv cov ntshav ntshav. Tej zaum koj yuav tsum tau nce koob tshuaj probenicide lossis sulfinpyrazone ntau dua. Cov tshuaj Thiazide tuaj yeem ua rau muaj peev xwm ntau ntxiv kev txhim kho kev tsis haum rau allopurinol.

Anticholinergics (piv txwv li atropine, biperiden)

Vim tias lub cev tsis zoo ntawm lub plab zom mov ua kom lub plab thiab lub plab tsis tuaj yeem, qhov lom neeg ntawm thiazide diuretics nce ntxiv.

Cytotoxic tus neeg sawv cev (piv txwv li cyclophosphamide, methotrexate)

Thiazides tuaj yeem txo qhov kev nthuav tawm ntawm cov tshuaj cytotoxic nyob rau hauv cov zis thiab potentiate lawv cov kev txiav txim siab txhawm rau txwv cov leeg pob txha muaj nuj nqi.

Thaum ua ntawv thov cov tshuaj loj ntawm salicylates, hydrochlorothiazide tuaj yeem txhim kho lawv cov kev mob lom rau hauv lub hauv nruab nrab cov hlab ntsha. ,

Cov teeb meem sib cais ntawm hemolytic anemia tau sau tseg nrog kev siv ua ke ntawm hydrochlorothiazide thiab methyldopa.

Kev siv cyclosporine ntaug tuaj yeem ua rau muaj kev pheej hmoo ntawm hyperuricemia thiab gouty ផលវិបាក.

Hypokalemia los yog hypomagnesemia los ntawm thiazide diuretics tuaj yeem ua rau muaj mob ntawm lub plawv dhia tsis ua haujlwm los ntawm digitalis.

Cov tshuaj uas qhov kev pauv pauv nrog kev hloov pauv hauv theem ntawm cov poov tshuaj hauv cov ntshav

Kev txiav txim siab ib zaug ntawm cov qib potassium thiab kev soj ntsuam ECG yog pom zoo thaum muaj kev sib xyaw ua ke ntawm losartan / hydrochlorothiazide thiab tshuaj, cov nyhuv ntawm uas yog nyob ntawm kev saib xyuas ntawm cov poov tshuaj hauv ntshav plasma (piv txwv, digitalis glycosides thiab tshuaj antiarrhythmic), nrog rau cov tshuaj uas ua rau “torsades de pointes” ( ventricular tachycardia), suav nrog qee cov tshuaj tiv thaiv antiarrhythmic (hypokalemia yog qhov ua ntej ntawm ventricular tachycardia):

chav kawm 1a cov tshuaj tiv thaiv kev puas hlwb (quinidine, hydroquinidine, disopyramide), chav kawm III cov tshuaj tiv thaiv kab mob (amiodarone, sotalol, dofetilide, ibutilide),

qee cov tshuaj tiv thaiv kev mob (thioridazine, chlorpromazine, levomepromazine, trifluoperazin, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol),

lwm tus (bepridil, cisapride, difemanil, erythromycin (rau kev tswj hwm), halofantrine, misolastine, pentamidine, terfenadine, vincamine (rau kev tswj hwm tshuaj)).

Thiazide diuretics tuaj yeem ua rau kom cov dej qab ntsev ntau ntxiv hauv cov ntshav ntshav los ntawm kev txo lawv cov kev tshem tawm. Yog tias tsim nyog, kev teem sijhawm siv cov tshuaj no yuav tsum saib xyuas cov tshuaj calcium thiab, raws li cov txiaj ntsig, nqa tawm kev hloov kho koob tshuaj.

Kev cuam tshuam rau kev kuaj pom

Los ntawm cuam tshuam rau cov metabolism hauv calcium, thiazide diuretics tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev tshawb fawb ntawm kev ua haujlwm ntawm cov qog parathyroid.

Muaj kev pheej hmoo ntawm cov tsos mob hyponatremia. Soj ntsuam thiab lom ntawm tus neeg mob yuav tsum.

Thaum lub cev qhuav dej tshwm sim los ntawm diuretics, qhov kev pheej hmoo ntawm lub raum tsis ua haujlwm nce ntau, tshwj xeeb tshaj yog nyob rau qib siab ntawm cov tshuaj iodine. Ua ntej siv xws li, tus neeg mob yuav tsum rov nqus dej.

Amphotericin B (rau kev tswj hwm hauv tsoomfwv), corticosteroids, ACTH lossis tshuaj laxatives

Hydrochlorothiazide tuaj yeem nce electrolyte tsis txaus, tshwj xeeb tshaj yog hypokalemia.

Daim ntawv thov nta

Qhov cuam tshuam rau kev muaj peev xwm tsav lub tsheb lossis lwm cov txheej txheem Thaum ua cov haujlwm uas yuav tsum tau saib xyuas ntau ntxiv (tsav tsheb, ua haujlwm nrog cov txheej txheem nyuaj), nws yuav tsum nco ntsoov tias kev kho mob siab ntsws qee zaum ua rau kiv taub hau thiab tsaug zog, tshwj xeeb tshaj yog thaum pib kho lossis thaum noj ntau ntxiv.

Kev tiv thaiv kev nyab xeeb

Cov neeg mob uas muaj keeb kwm mob vwm yuav tsum tau saib xyuas mob tsis zoo (o ntawm lub ntsej muag, daim di ncauj, caj pas, thiab / lossis tus nplaig).

Hypotension thiab tshem tawm ntawm intravascular ntim

Hauv cov neeg mob hypovolemia thiab / los yog hyponatremia (vim kev kho mob diuretic ntau, kev noj zaub mov nrog cov tshuaj sodium txo qis, ntuav lossis ntuav), hypotension yuav tshwm sim, tshwj xeeb yog tom qab noj thawj koob. Cov mob no yuav tsum tau kho ua ntej pib kev kho mob.

Kev ntsuas hluav taws xob tsis txaus

Kev xaiv ntshav tsis txaus yog feem ntau pom hauv cov neeg mob raum tsis ua haujlwm, tshwj xeeb yog muaj ntshav qab zib. Yog li, thaum kho, cov concentration ntawm cov poov tshuaj nyob rau hauv cov ntshav ntshav thiab cov ntshiab si creatinine yuav tsum tau saib xyuas, tshwj xeeb, hauv cov neeg mob nrog creatinine tshem ntawm 30 - 50 ml / min.

Lub siab ua haujlwm tsis zoo

Cov tshuaj Lorista ND yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj keeb kwm muaj mob me los yog nruab nrab lub cev ua haujlwm tsis zoo.

Txij li thaum tsis muaj cov ntaub ntawv qhia txog kev siv tshuaj losartan hauv cov neeg mob uas tsis muaj peev xwm kho kabmob hnyav, cov tshuaj Lorista ND yog qhov sib kis ntawm cov neeg mob no. kuv

Lub raum khiav tsis zoo

Raws li qhov tshwm sim ntawm kev tawm tsam ntawm renin-angiotensin-aldosterone-1g-system, kev hloov pauv hauv kev ua haujlwm hauv lub raum, suav nrog lub raum tsis ua haujlwm, tau sau tseg (tshwj xeeb, hauv cov neeg mob uas muaj kev cia siab ntawm lub raum ua haujlwm ntawm renin-angiotensin-aldosterone system: cov neeg mob lub plawv tsis ua haujlwm loj los yog mob raum tsis zoo).

Ib yam li lwm yam tshuaj uas cuam tshuam rau renin-angiotensin-aldosterone system, cov neeg mob uas muaj ob sab raum txoj hlab ntsha leeg los yog txoj hlab ntshav ntawm lub raum ib zaug tau pom muaj kev nce qib ntawm urea thiab creatinine, cov kev hloov no thim rov qab thaum kev kho tsis ua haujlwm lawm. Siv kev ceev faj nrog losartan nyob rau hauv cov neeg mob uas muaj ob sab raum leeg mob stenosis los yog txoj leeg ntshav ntawm ib lub raum.

Tsis muaj ntaub ntawv qhia txog kev siv cov tshuaj rau cov neeg mob ua lub raum phais qhov muag.

Hauv cov neeg mob uas muaj hyperaldosteronism thawj zaug, raws li txoj cai, tsis muaj kev tawm tsam los ntawm cov tshuaj tiv thaiv kev tiv thaiv kabmob uas ua rau txo cov kab mob renin-angiotensin. Yog li no, kev siv ua ke ntawm losartan / hydrochlorothiazide tsis pom zoo.

Coronary mob plawv thiab cerebrovascular mob lub siab

Ib yam li lwm yam tshuaj tiv thaiv kab mob ntshav siab, txo qis ntshav siab hauv cov neeg mob mob plawv thiab cov kab mob cerebrovascular tuaj yeem ua rau myocardial infarction lossis mob stroke. Lub plawv tsis ua hauj lwm

Cov neeg mob uas lub plawv tsis ua hauj lwm (nrog los sis tsis mob raum tsis ua hauj lwm) muaj qhov pheej hmoo ntau ntxiv txhim kho txoj hlab ntshav liab thiab raum tsis ua haujlwm (feem ntau mob ceev).

Mitral lossis aortic valve stenosis, ob leeg mob hypertrophic cardiomyopathy

Ib yam li lwm cov vasodilators, yuav tsum tau saib xyuas tshwj xeeb thaum kho cov tshuaj rau cov neeg mob aortic stenosis, mitral valve stenosis, thiab ob leeg mob hypertrophic cardiomyopathy.

Cov tshuaj tiv thaiv ntawm angiotensin-hloov ua enzyme, losartan, thiab lwm cov kev tawm tsam angiotensin tau pom tias muaj cov nyhuv tsis muaj hypotensive thaum siv rau hauv cov neeg ntawm haiv neeg African. Tej zaum qhov xwm txheej no tau piav qhia los ntawm qhov tseeb tias pawg neeg mob no feem ntau muaj cov ntshav qis tsis txaus hauv cov ntshav. Cev xeeb tub

Angiotensin II receptor inhibitors (ARA-I) yuav tsum tsis txhob noj thaum cev xeeb tub. Yog tias ua tau, tom qab ntawd cov neeg mob npaj lub cev xeeb tub yuav tsum tau txiav txim siab lwm txoj kev tiv thaiv kev tiv thaiv mob, uas tau ua pov thawj lawv tus kheej hais txog kev nyab xeeb thaum siv thaum cev xeeb tub. Tom qab cev xeeb tub yog tsim los pab, ARA-Kuv yuav tsum tau tsum tsis txhob tsum kiag tam sim ntawd thiab lwm txoj kev kho ntxiv yog tsim nyog.

Hypotension thiab dej-electrolyte tsis txaus

Ib yam li lwm txoj kev kho mob antihypertensive, qee cov neeg mob yuav muaj cov tsos mob ntawm txoj hlab ntshav liab txoj hlab ntshav hypotension. Yog li, kev txheeb xyuas cov txheej txheem yuav tsum tau ua los txheeb xyuas cov kev kuaj mob ntawm dej-electrolyte tsis txaus (hypovolemia, hyponatremia, hypochloremic alkalosis, hypomagnesemia los yog hypokalemia), piv txwv, tom qab zawv plab lossis ntuav. Hauv cov neeg mob zoo li no, yuav tsum tau saib xyuas cov khoom hluav taws xob tsis tu ncua. ntshav. Nyob rau hauv yoga, cov neeg mob kev txom nyem los ntawm edema yuav muaj dilated hyponatremia.

Kev cuam tshuam ntawm cov metabolism thiab endocrine system

Kev pabcuam Thiazide tuaj yeem ua rau tsis xav txog cov ntshav qabzib. xav tau koob tshuaj kho cov tshuaj tiv thaiv kab mob, incl. tshuaj insulin Thaum siv cov tshuaj thiazide, kev mob ntshav qab zib mentitus tuaj yeem tshwm sim. Thiazides tuaj yeem txo qhov kev nthuav dav ntawm calcium nyob hauv cov zis thiab, yog li, ua rau lub sijhawm luv luv tsis txaus ntseeg nyob hauv nws cov concentration hauv cov ntshav ntshav. Kev mob hypercalcemia ntau yuav qhia tias mob latent hyperparathyroidism. Ua ntej tshuaj xyuas kev ua haujlwm ntawm cov qog ntshav parathyroid, thiazide diuretics yuav tsum tau txiav tawm.

Kev siv cov thiazide diuretics tuaj yeem cuam tshuam nrog kev nce hauv cov roj (cholesterol) thiab triglycerides.

Hauv qee tus neeg mob, kev kho thiazide tuaj yeem ua rau hyperuricemia thiab / lossis muaj mob ntawm gout. Txij li thaum losartan txo qhov kev xav ntawm uric acid, nws txoj kev sib xyaw nrog hydrochlorothiazide txo qhov ntxim nyiam ntawm hyperuricemia cuam tshuam nrog kev siv tshuaj diuretics.

Lub siab ua haujlwm tsis zoo

Hauv cov neeg mob uas lub siab tsis ua haujlwm lossis mob siab rau daim siab, thiazides yuav tsum siv nrog ceev faj, vim lawv tuaj yeem ua rau mob cholestasis mob siab, thiab kev hloov pauv me me hauv cov kua dej thiab electrolyte sib npaug tuaj yeem ua rau lub siab tsis tuaj yeem hauv lub siab. Lorista ND yog contraindicated rau hauv cov neeg mob uas muaj teeb meem loj hepatic.

Cov neeg mob uas siv thiazides tuaj yeem ntsib kev tiv thaiv qhov mob hypersensitivity, tsis hais lawv puas muaj keeb kwm ua xua lossis hawb pob bronchial. Muaj cov ntawv tshaj tawm ntawm exacerbation lossis rov pib dua ntawm cov kab mob lupus erythematosus nrog kev siv tshuaj thiazide.

Sab sij huam

Feem ntau, kev kho nrog kev sib xyaw ntawm hydrochlorothiazide + losartan tau pom zoo zoo. Feem ntau, cov kev mob tshwm sim me me, hloov mus, thiab tsis tas yuav tsum tsis kho ntxiv.

Hauv kev tswj xyuas cov kab mob hauv kev kho mob ntshav siab, kiv taub hau tsuas yog qhov tshwm sim tsis zoo cuam tshuam nrog kev noj tshuaj, qhov zaus uas dhau li ntawm thaum noj cov placebo los ntawm ntau dua 1%. Raws li qhia hauv kev tswj xyuas cov kev sim, losartan hauv kev sib xyaw nrog hydrochlorothiazide feem ntau pom zoo zoo rau cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy. Feem ntau cov kev phiv tshuaj yog kiv taub hau uas tsis muaj qhov ntswg thiab tsis muaj zog, tsis muaj zog / nkees muaj zog. Thaum lub sijhawm sau npe tom qab siv cov tshuaj sib txuas no, kev sim tshuaj thiab / lossis kev sau npe tom qab siv tus kheej cov txheej txheem ntawm kev sib xyaw, cov kev coj ua tsis zoo ntxiv tau raug tshaj tawm.

Kev cuam tshuam los ntawm cov ntshav thiab cov lymphatic system: thrombocytopenia, ua haujlwm ntshav, aplastic anemia, hemolytic anemia, leukopenia, agranulocytosis.

Lub cev tsis muaj zog tiv thaiv kab mob: anaphylactic kev ua xua, mob taub hau, nrog rau o ntawm lub suab nrov thiab lub suab nrov nrov nrog kev txhim kho ntawm ob leeg ntawm txoj hlab pa thiab / lossis o ntawm lub ntsej muag, daim di ncauj, pharynx thiab / lossis tus nplaig hauv cov neeg mob noj losartan, tsis tshua tau pom (≥0.01% thiab 5.5 meq / l) tau pom nyob rau 0.7% ntawm cov neeg mob, txawm li cas los xij, hauv cov kev tshawb fawb no tsis tas yuav tsum tshem tawm txoj kev sib xyaw ntawm hydrochlorothiazide + losartan vim tshwm sim ntawm hyperkalemia. Ib qho kev nce ntxiv ntawm plasma alanine aminotransferase kev ua si yog qhov tsis tshua muaj thiab feem ntau rov qab mus rau qhov qub tom qab tsis kho.

Noj ntau dhau
Tsis muaj cov ntaub ntawv hais txog cov kev kho mob tshwj xeeb ntawm kev siv ntau tshaj nrog kev sib xyaw ntawm hydrochlorothiazide + losartan. Txoj kev kho yog mob yam ntxwv thiab txhawb nqa. Cov tshuaj Lorista ® ND yuav tsum tsis ua txuas ntxiv, thiab tus neeg mob yuav tsum tau saib xyuas. Yog tias cov tshuaj noj tsis ntev los no, nws raug nquahu kom ua rau ntuav, nrog rau kev tshem tawm ntawm lub cev qhuav dej, dej-electrolyte cuam tshuam, mob hepatic thiab txo qis ntshav siab los ntawm cov qauv kev.

Losartan
Cov ntaub ntawv ntau dhau siv tsawg. Qhov feem ntau yuav cuam tshuam ntawm kev noj haus ntau dhau yog qhov cim txo qis rau cov ntshav siab thiab tachycardia, bradycardia tuaj yeem tshwm sim vim kev xav ntawm parasympathetic (paum). Nyob rau hauv cov ntaub ntawv ntawm kev loj hlob ntawm cov tsos mob arterial hypotension, txij nkawm txoj kev kho yog qhia.
Kev Kho Mob: mob kev kho mob.
Losartan thiab nws cov metabolite nquag tsis raug tshem tawm los ntawm hemodialysis.

Hydrochlorothiazide
Cov tsos mob uas nquag muaj tshaj yog vim muaj cov roj ntsha tsis muaj ntshav txaus (hypokalemia, hypochloraemia, hyponatremia) thiab lub cev qhuav dej vim cov diuresis ntau dhau. Nrog kev tswj hwm tib lub sijhawm ntawm lub plawv glycosides, hypokalemia tuaj yeem ua rau phem chav kawm ntawm arrhythmias.
Nws tsis yog tsim rau dab tsi li hydrochlorothiazide tuaj yeem raug tshem tawm ntawm lub cev los ntawm hemodialysis.

Lub npe thiab chaw nyob ntawm tus tuav (tuav) daim ntawv pov thawj rau npe

Chaw tsim tshuaj paus:
1. JSC “Krka, hnub, Novo mesto”, Lub Tsib Hlis 6, 8501 Novo mesto, Slovenia
2. LLC "KRKA-RUS",
143500, Russia, Moscow Cheeb Tsam, Istra, ul. Moskovskaya, d. 50
nyob rau hauv kev koom tes nrog JSC “Krka, hnub, Novo mesto”, Tsib Hlis 6, 8501 Novo mesto, Slovenia

Thaum ntim khoom thiab / lossis ntim khoom ntawm chaw haujlwm Lavxias, nws yog qhov qhia:
KRKA-RUS LLC, 143500, Russia, Moscow Cheeb Tsam, Istra, ul. Moskovskaya, d. 50

Lub npe thiab chaw nyob ntawm lub koom haum txais cov neeg siv khoom kev tsis txaus siab
LLC KRKA-RUS, 125212, Moscow, Golovinskoye Shosse, Lub Tsev 5, Lub Tsev 1

Tso cov ntaub ntawv thiab cov nyob ua ke

Muaj nyob hauv ntsiav tshuaj daim ntawv. Npaj rau kev siv lub qhov ncauj. Cov ntsiav tshuaj muaj cov khoom xyaw hauv qab no:

• cov khoom siv tseem ceeb yog losartan, 100 mg,
• hydrochlorothiazide - 25 mg.

Cov tshuaj muaj nyob hauv ib qhov ntau npaum 12, 25, 50 thiab 100 mg.

Lorista ND yog muaj nyob hauv ntsiav tshuaj daim ntawv.

Cov Tshuaj Pharmacokinetics

Qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw pom ib teev tom qab noj cov ntsiav tshuaj. Kev kho mob nyhuv ntev li 3-4 teev. Li ntawm 14% ntawm losartan, noj ntawm qhov ncauj, yog metabolized rau nws cov metabolite nquag. Ib nrab-lub neej ntawm losartan yog 2 teev. Hydrochlorothiazide tsis yog metabolized thiab raug tawm sai sai los ntawm lub raum.

Dab tsi pab?

Cov tshuaj yog kws kho nyob rau hauv cov xwm txheej zoo li no:

1. Arterial tawg.
2. Raws li kev txhawb pab txhawb kom txo kev tuag ntawm cov neeg kev txom nyem los ntawm sab laug ventricular hypertrophy los yog mob ntshav siab heev.
3. Kev tiv thaiv ntawm kev pheej hmoo ntawm tus cwj nrag, mob plawv nres, myocardial kev puas tsuaj hauv pathologies ntawm cov hlab plawv system.
4. Kev ua haujlwm tsis txaus siab thiab ib leeg tsis haum rau isoenzyme inhibitors.
5. Arterial hypertension, tsim tawm tsam keeb kwm ntawm ntshav qab zib mellitus, lub raum tsis ua haujlwm.
6. Lub plawv dhia tsis zoo.
7. Myocardial infarction nyob rau hauv daim ntawv mob.
8. Lub plawv tsis ua hauj lwm nyuaj los ntawm concomitant teev kev.

Cov tshuaj tau raug pom zoo raws li kev tiv thaiv kev kho mob txhawm rau npaj cov neeg mob uas lub raum tsis ua haujlwm rau kev kho mob hemodialysis.

Cov tshuaj tuaj yeem tuaj yeem pom zoo ua cov txheej txheem ntawm txoj kev kho mob tsom rau kev npaj cov neeg mob uas lub raum tsis ua haujlwm rau kev kho mob hemodialysis.

Nrog saib xyuas

Nrog kev nce ceeb toom, Lorista yog kho rau cov neeg mob uas muaj cov kab mob hauv qab no:

• mob ntshav qab zib mellitus
• bronchial hawb pob,
• kab mob ntev ntawm cov ntshav,
• ua txhaum ntawm cov dej-electrolyte sib npaug hauv lub cev,
• lub raum leeg mob stenosis,
• ua txhaum ntawm cov ntshav ncig thiab microcirculation,
• mob rau cov hlab ntshav
• cardiomyopathy
• mob plawv dhia tsis tu ncua ntawm lub plawv nres.

Hauv txhua qhov xwm txheej no, cov tshuaj raug tawm hauv cov tshuaj tsawg kawg, thiab chav kho mob tau nyob hauv kev saib xyuas mob nkeeg nruj.

Yuav ua li cas coj Lorista ND?

Tsim rau kev siv sab hauv tsev. Cov ntsiav tshuaj tau noj tom qab noj mov, ntxuav tag nrog ntau cov dej huv. Cov tshuaj noj kom zoo dua yog xaiv raws li cov phiaj xwm ib tus neeg coj mus rau hauv tus lej hnub nyoog ntawm tus neeg mob thiab tus kab mob tau kuaj pom nrog nws.

Qhov koob tshuaj ntau tshaj txhua hnub ntawm Lorista yuav tsum tsis pub tshaj 50 mg.

Qee qhov xwm txheej, cov koob tshuaj yuav raug nce los ntawm tus kws kho mob mus rau 100 mg ntawm cov tshuaj ib hnub. Qhov nruab nrab ntawm kev kho mob yog los ntawm 3 lub lis piam mus rau 1.5 hli.

Cov ntsiav tshuaj tau noj tom qab noj mov, ntxuav tag nrog ntau cov dej huv.

Kev kho mob pib nrog kev noj tshuaj tsawg kawg - los ntawm 12-13 mg Lorista ib hnub. Tom qab ib lub lim tiam, cov tshuaj txhua hnub yog nce rau 25 mg. Tom qab ntawd cov tshuaj noj yog npaum li cas nyob rau hauv ib tug tshuaj ntawm 50 mg.

Nrog rau cov hlab ntsha o, qhov kev noj tshuaj txhua hnub tuaj yeem yog los ntawm 25 txog 100 mg. Thaum sau daim ntawv noj tshuaj kom ntau, qhov ib hnub yuav tsum muab faib ua ob zaug. Thaum lub sij hawm txoj kev kho mob nrog qhov nce ntxiv ntawm cov tshuaj diuretic, Lorista tau sau tseg hauv 25 mg.

Qhov txo koob tshuaj yog qhov yuav tsum tau ua rau cov neeg mob uas tsis muaj peev xwm ua rau mob hepatic, lub raum tsis ua haujlwm.

Nrog ntshav qab zib

Kev kho mob pib nrog kev noj tshuaj ntau npaum li 50 mg. Cov ntsiav tshuaj tau noj 1 zaug hauv ib hnub. Yav tom ntej, cov koob tshuaj tau nce ntxiv rau 80-100 mg, kuj noj ib hnub ib zaug.

Hauv cov kab mob ntshav qab zib mellitus, kev kho mob pib nrog ntau npaum ntawm 50 mg.

Kev kho mob txoj hnyuv

• flatulence
• xeev siab thiab txhaws ntuav
• tso quav tsis taus
• mob plab
• mob hauv plab.

Txais tos Lorista tuaj yeem tsim teeb meem kev quav.

Nruab nrab hauv lub paj hlwb

Kev tawm tsam mob taub hau, kev nyuaj siab, pw tsaug zog, tsaus muag, mob nkees ntev, kiv taub hau, tsis muaj peev xwm nco qab cov ntaub ntawv tshiab thiab kev xav zoo, cuam tshuam ntawm kev txav mus los.

Kev tawm tsam ntawm mob taub hau yuav tshwm sim thaum noj Lorista.

Cov tshuaj tuaj yeem ua rau kev txhim kho ntawm kev fab tshuaj, tshwm sim hauv daim ntawv ntawm:

• mob ntsws npog
• hnoos
• daim tawv nqaij ua pob zoo li khaus,
• khaus tawv.

Cov lus qhia tshwj xeeb

Vim tias qhov cuam tshuam dhau los ntawm lub hauv nruab nrab lub paj hlwb thiab qhov txo qis ntshav siab thaum kho, Lorista yog qhov zoo dua rau kev txwv tsis pub tswj cov tshuab thiab tsheb.

Thaum kho, Lorista yog qhov zoo dua rau kev tsis kam ntawm kev tsav tshuab thiab tsheb.

Thaum lub sij hawm kho mob hauv chav kawm, nws raug nquahu kom soj ntsuam cov ntshav calcium calcium txhawm rau kom tsis txhob muaj kev loj hlob ntawm hypercalcemia.

Lub Sijhawm Lorista ND cov me nyuam

Vim tias qhov tsis txaus kawm tau siv ntawm Lorista rau ntawm cov menyuam yaus lub cev, cov tshuaj tsis tau siv los kho cov menyuam yaus hnub nyoog qis dua feem ntau.

Cov tshuaj tsis raug siv los kho menyuam yaus hnub nyoog qis dua feem ntau.

Siv thaum cev xeeb tub thiab lactation

Vim nws cov nyhuv tshuaj lom, cov tshuaj muaj peev xwm ua tsis zoo rau kev tsim cov hlab plawv thiab lub raum ua kom muaj menyuam hauv plab thaum lub cev xeeb tub, uas yog fraught nrog kev tuag. Txoj kev pheej hmoo rau tus me nyuam hauv plab yog qhov tshwj xeeb tshaj plaws nyob rau hauv thawj ob lub trimesters ntawm cev xeeb tub. Vim li no, Lorista tsis tau siv los kho cov poj niam cev xeeb tub.

Tsis txhob siv Lorista thaum pub mis. Yog tias tsim nyog, kev siv cov tshuaj tiv thaiv kabmob no ib ntus rau kev pub mis.

Daim ntawv thov rau lub raum khiav tsis zoo

Thaum lub raum ua rau lub raum tsis ua haujlwm ntawm qhov mob sib khuav ntawm qhov hnyav mus rau qhov hnyav, cov tshuaj tau raug muab tshuaj hauv cov khoom noj tshuaj txheem. Hauv cov xwm txheej loj tshwj xeeb, kev txiav txim siab txog kev noj tshuaj kom zoo thiab muaj peev xwm ua tau thov Lorista yog coj los ntawm tus kws kho mob ib leeg zuj zus.

Thaum lub raum ua rau lub raum tsis ua haujlwm ntawm qhov mob sib khuav ntawm qhov hnyav mus rau qhov hnyav, cov tshuaj tau raug muab tshuaj hauv cov khoom noj tshuaj txheem.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog rau kev siv Lorista ib txhij nrog lwm cov tshuaj tiv thaiv kabmob ntshav, kom maj nrawm thiab ua rau cov ntshav ntsuas tau tiav.

Kev sib xyaw nrog cov tshuaj tiv thaiv thiab tshuaj tua kab mob tuaj yeem cuam tshuam kev loj hlob ntawm vau.

Barbiturates thiab mob glycosides ua ke zoo nrog Lorista, tsis zoo li Rifampicin, uas txo cov hauj lwm zoo ntawm cov tshuaj no. Asparkam yog sib haum nrog Lorista, tab sis nrog kev siv ua ke nrog cov tshuaj no, kev tswj nce qib ntawm cov calcium uas xav tau.

Cawv tau zoo

Thaum kho, Lorista categorically contraindicated kev siv dej cawv haus. Kev haus cawv Ethyl ua rau tus neeg mob tuaj yeem tsim kev pheej hmoo txaus ntshai xws li mob plawv nres thiab mob ntshav nce hlwb.

Thaum kho, Lorista categorically contraindicated kev siv dej cawv haus.

Qhov tseem ceeb hloov rau cov tshuaj no yog Lorista N. Cov tshuaj nram qab no tuaj yeem hloov mus rau losartan:

Cia rau cov mob rau cov tshuaj

Cov tshuaj no raug nquahu kom cia hauv qhov chaw tsaus ntuj, txias qhov chaw tsis ncav cuag ntawm cov menyuam yaus. Kev cia qhov kub zoo tshaj yog txog + 30 ° С.

Cov tshuaj no raug nquahu kom cia hauv qhov chaw tsaus, txias qhov chaw tsis ncav cuag ntawm cov menyuam yaus.

Kev kho plawv

Valeria Nikitina, kws kho plawv, Moscow

Kev siv ntawm Lorista ND tso cai rau koj kom tsis txhob muaj kev loj hlob ntawm cov teeb meem txaus ntshai ntawm pathologies ntawm cov hlab plawv raws li mob hlab ntsha tawg thiab myocardial infarction. Hauv kev xaiv cov koob tshuaj kom raug, cov tshuaj tau zoo los ntawm cov neeg mob tsis muaj kev txhim kho ntawm kev phiv.

Valentin Kurtsev, tus xibfwb, kws kho plawv, Kazan

Kev siv cov Lorista yog dav nyob hauv thaj chaw kho plawv. Cov kev siv tshuaj kho mob thiab cov txiaj ntsig ntawm kev sim tshuaj tau ua pov thawj tias cov tshuaj txo qis kev tuag ntawm cov neeg mob uas kuaj pom lub plawv tsis ua haujlwm thiab kub siab.

Cov tshuaj tau yeej ib tug loj ntawm cov zoo xyuas los ntawm ob qho tib si tus neeg mob thiab kws kho mob.

Nina Sabashuk, 35 xyoo, Moscow

Kuv tau raug mob ntshav siab tau 10 xyoo. Tom qab kuv paub mob ntshav siab, Kuv tau noj tshuaj ntau, tab sis tsuas yog siv Lorista ND tso cai rau kuv kom kuv tus mob sai sai thiab rov qab los rau kuv lub neej ib txwm nyob li ob peb hnub.

Nikolay Panasov, 56 xyoo, Dav Dawb hau

Kuv lees yuav Lorista ND tau ntau xyoo. Cov tshuaj sai sai ua rau lub siab rov zoo li qub, muab cov nyhuv zoo zoo. Thiab tus nqi ntawm cov tshuaj yog muaj nqis, uas kuj tseem ceeb.

Alexander Panchikov, 47 xyoo, Yekaterinburg

Kuv muaj lub siab tsis ua hauj lwm nrog ib qho kev kawm nyuaj. Nrog kev tshem tawm tus kabmob, tus kws kho mob tau sau ntawv kom coj Lorista ND ntsiav tshuaj. Kuv tau txaus siab rau cov txiaj ntsig. Txawm hais tias muaj kev ncaj ncees los ntawm cov kev mob tshwm sim, cov tshuaj no tuaj txog zoo.