Insulin Lantus (Glargine): Nrhiav txhua yam koj xav tau. Hauv qab no koj yuav pom sau ua lus yooj yim. Nyeem seb muaj pes tsawg qhov koj yuav tsum tau nkag mus thiab thaum twg, yuav ua li cas los xam lub koob tshuaj, yuav siv li cas Xantus Solostar syringe mem. Nkag siab ntev npaum li cas tom qab txhaj tshuaj no pib ua yeeb yam, uas qhov insulin zoo dua: Lantus, Levemir lossis Tujeo. Ntau cov kev tshuaj xyuas ntawm cov neeg mob ntshav qab zib hom 2 thiab 1 tau muab.

Glargin yog kev ua haujlwm ntev ntev tsim los ntawm lub tuam txhab thoob ntiaj teb lub koob npe nrov Sanofi-Aventis. Tej zaum qhov no yog cov tshuaj insulin nrov tshaj plaws ntawm cov neeg mob ntshav qab zib hais lus Lavxias. Nws qhov kev txhaj tshuaj xav tau ntxiv cov kev kho mob uas tso cai rau koj kom cov ntshav qab zib 3.9-5.5 mmol / l ruaj khov 24 teev ib hnub, ib yam li hauv cov neeg noj qab haus huv. Ib qhov system tau nyob nrog tus mob ntshav qab zib ntau dua 70 xyoo tso cai rau cov neeg laus thiab cov menyuam muaj ntshav qab zib tuaj yeem tiv thaiv lawv tus kheej los ntawm cov teeb meem hnyav.

Nyeem cov lus teb rau cov lus nug:

Cov insulin ntev ntev: cov ncauj lus ntxaws ntxaws

Nco ntsoov tias piam insulin Lantus zoo li pob tshab. Los ntawm cov tsos ntawm cov tshuaj, nws tsis tuaj yeem txiav txim siab nws qhov zoo. Koj yuav tsum tsis txhob yuav cov tshuaj insulin thiab cov tshuaj kim los ntawm koj txhais tes, raws li kev tshaj tawm ntiag tug. Tau txais cov tshuaj ntshav qab zib los ntawm cov chaw muag tshuaj muaj npe uas ua raws li txoj cai khaws cia.

Cov lus qhia rau kev siv

Thaum txhaj cov Lantus npaj, ib yam li lwm hom insulin, koj yuav tsum ua raws li kev noj zaub mov noj.

Cov khoom noj muaj xaiv nyob ntawm kev kuaj mob:

Ntau tus neeg mob ntshav qab zib uas txhaj tshuaj insulin glargine xav tias nws ua tsis tau kom tsis txhob muaj kev mob ntshav qab zib. Qhov tseeb, tuaj yeem khaws cov suab thaj kom ruaj khov Txawm hais tias muaj mob hnyav autoimmune. Thiab ntau heev tshaj dua yog li, nrog cov mob hnyav hom 2 mob ntshav qab zib. Tsis tas yuav ua los ntxiv cov ntshav qabzib hauv koj lub cev txhawm rau kom raug tus kheej tiv thaiv ntshav qabzib ntshav qab zib. Saib cov vis dis aus uas tham txog qhov teeb meem no. Kawm seb yuav ua li cas sib npaug ntawm cov khoom noj thiab cov tshuaj insulin.

Cev xeeb tub thiab pub niam mis

Feem ntau cov yuav, Lantus tuaj yeem siv kom nyab xeeb kom tsis muaj piam thaj hauv poj niam cev xeeb tub. Tsis muaj kev raug mob tshwm sim rau cov poj niam lossis menyuam yaus. Txawm li cas los xij, muaj tsawg dua cov ntaub ntawv ntawm cov tshuaj no dua li ntawm cov tshuaj insulin. Nco ntsoov qhia nws yog tias tus kws kho mob tau xaiv. Sim ua yam tsis muaj insulin txhua yam, ua raws kev noj haus zoo. Nyeem kab lus “” thiab “” kom paub cov ntsiab lus.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj uas tuaj yeem txhim kho cov tshuaj insulin muaj xws li txo cov tshuaj qab zib, nrog rau ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates thiab sulfonamides. Kev nqis tes ua cov tshuaj insulin: danazol, diazoxide, diuretics, glucagon, isoniazid, estrogens, gestagens, phenothiazine derivatives, somatotropin, epinephrine (adrenaline), salbutamol, terbutaline thiab cov thyroid hormones, protease inhibitors, olanzapine. Tham nrog koj tus kws kho mob txog txhua yam tshuaj koj noj!

Noj ntau dhau	Cov ntshav qab zib tuaj yeem txo qis. Muaj kev pheej hmoo ntawm qhov tsis nco qab zoo, tsis nco qab, tsis tuaj yeem lub hlwb puas tsuaj, thiab txawm hais tias tuag. Rau lub sijhawm ntev ntawm cov tshuaj insulin glargine, qhov kev pheej hmoo no yuav qis dua rau cov tshuaj nrog qhov kev txiav txim luv luv thiab ultrashort. Nyeem yuav ua li cas muab kev pabcuam rau tus neeg mob nyob hauv tsev thiab hauv tsev kho mob.
Daim ntawv tso tawm	Cov Insulin Lantus raug muag hauv 3 ml cartridges ntawm cov iav ntshiab, tsis muaj kob. Daim cartridges tuaj yeem raug tsa nyob rau hauv SoloStar cov koob txhaj tshuaj. Tej zaum koj yuav pom cov tshuaj no ntim hauv 10 ml vials.
Cov lus thiab cov xwm txheej ntawm kev cia	Txhawm rau kom tsis txhob noj ib hom tshuaj muaj txiaj ntsig, kawm thiab ua tib zoo ua raws lawv. Txee lub neej yog 3 xyoos. Khaws tsis ncav cuag ntawm cov menyuam yaus.
Muaj pes tsawg leeg	Cov tshuaj nquag yog insulin glargine. Cov neeg zam - metacresol, zinc chloride (sib xyaw rau 30 μg ntawm zinc), 85% glycerol, sodium hydroxide thiab hydrochloric acid - txog pH 4, dej rau kev txhaj tshuaj.

Saib hauv qab no rau cov lus qhia ntxiv.

Lantus yog ib cov tshuaj ntawm dab tsi txiav txim? Yog ntev lossis luv?

Lantus yog ib qho insulin ntev ntev. Txhua koob tshuaj ntawm cov tshuaj no yuav txo cov ntshav qab zib nyob hauv 24 teev. Txawm li cas los xij, kev txhaj ib hnub ib hnub tsis txaus. Xav pom zoo kom txhaj cov tshuaj insulin ntev ntev 2 zaug hauv ib hnub - sawv ntxov thiab yav tsaus ntuj. Nws ntseeg tias Lantus nce qhov kev pheej hmoo ntawm mob qog noj ntshav, thiab nws yog qhov zoo dua rau hloov mus rau Levemir kom zam qhov no. Saib daim yeeb yaj kiab kom paub meej ntxiv. Nyob rau tib lub sijhawm, kawm yuav tsum khaws cov tshuaj insulin kom zoo nws thiaj tsis puas.

Qee tus neeg, vim qee lub laj thawj, tab tom nrhiav luv luv insulin hu ua Lantus. Cov tshuaj no tsis yog muag thiab yeej tsis tau.

Koj tuaj yeem hno cov insulin txuas ntxiv thaum hmo ntuj thiab yav sawv ntxov, nrog rau ib qho ntawm cov tshuaj hauv qab no ua ntej noj mov: Actrapid, Humalog, Apidra lossis NovoRapid. Ntxiv rau qhov saum toj no, muaj ob peb hom kev yoo insulin uas tso tawm hauv Lavxias thiab Tebchaws CIS. Tsis txhob sim hloov cov kev txhaj tshuaj ntawm luv luv lossis ultrashort insulin ua ntej noj mov nrog cov koob tshuaj ntev ntev. Qhov no yuav ua rau txoj kev loj hlob ntawm tus mob, thiab thaum kawg nws muaj mob ntshav qab zib.

Nyeem txog hom insulin sai uas tuaj yeem ua ke nrog Lantus:

Nws ntseeg tias Lantus tsis muaj lub ncov ntawm kev nqis tes, tab sis txo qis suab thaj tusyees rau 18-24 teev. Txawm li cas los xij, ntau tus neeg mob ntshav qab zib hauv lawv qhov kev tshuaj xyuas rau ntawm cov ntawv foob tau hais tias tseem muaj lub ncov siab, txawm hais tias tsis muaj zog.

Cov tshuaj insulin glargine ua haujlwm ncaj qha dua lwm cov tshuaj ntawm cov tshuaj hauv nruab nrab. Txawm li cas los xij, nws ua haujlwm ntau dua, thiab txhua qhov ntawm nws cov kev txhaj tshuaj ntev txog li 42 teev. Yog tias muaj nyiaj txiag pub, mam li txiav txim siab hloov Tresib nrog cov tshuaj tshiab.

Muaj pes tsawg Lantus chav nyob rau prick thiab thaum twg? Yuav ua li cas los xam cov koob tshuaj?

Qhov zoo tshaj plaws ntawm koob tshuaj insulin ntev ntev, nrog rau cov sijhawm teem sijhawm ntawm kev txhaj tshuaj, nyob ntawm cov yam ntxwv ntawm cov chav kawm ntawm cov ntshav qab zib hauv tus neeg mob. Cov lus nug uas koj nug yuav tsum muab qhia rau tus kheej. Nyeem kab lus “”. Ua raws li nws tau sau rau hauv nws.

Npaj txhij-ua universal insulin txoj kev kho tsis tuaj yeem muab cov ntshav qab zib nyob ruaj khov, txawm hais tias tus neeg mob ntshav qab zib. Yog li ntawd, nws tsis pom zoo kom lawv siv thiab lub xaib tsis sau txog lawv.

Kev kho mob ntshav qab zib insulin - yuav pib qhov twg:

Thaum twg yog qhov zoo dua rau nkaug Lantus: yav tsaus ntuj lossis thaum sawv ntxov? Puas yog nws tuaj yeem ncua sijhawm txhaj tshuaj thaum yav sawv ntxov?

Yav tsaus ntuj thiab txhaj tshuaj thaum txuas ntxiv ntawm cov insulin yog qhov xav tau rau lub hom phiaj sib txawv. Cov lus nug txog lawv lub hom phiaj thiab kev xaiv tshuaj yuav tsum hais daws ntawm ib leeg. Raws li txoj cai, feem ntau muaj teeb meem nrog cov piam thaj tom qab thaum sawv ntxov ntawm lub plab khoob. Txhawm rau coj nws rov qab zoo li qub, ua ib qho kev txhaj tshuaj ntawm cov tshuaj insulin ntev thaum hmo ntuj.

Yog tias tus mob ntshav qab zib muaj ntshav qabzib feem ntau thaum sawv ntxov nyob rau ntawm lub plab khoob, tom qab ntawd nws yuav tsum tsis txhob txhaj Lantus thaum tsaus ntuj.

Kev txhaj tshuaj thaum ntxov ntawm cov insulin ntev yog tsim los ua kom cov qab zib nyob rau hauv nruab hnub thaum lub plab khoob. Koj tsis tuaj yeem sim hloov qhov kev txhaj tshuaj ntawm qhov loj ntawm cov tshuaj Lantus thaum sawv ntxov, kev qhia ntawm cov kua dej sai ua ntej noj mov. Yog tias cov piam thaj feem ntau dhia tom qab noj mov, koj yuav tsum siv ob hom tshuaj insulin nyob rau tib lub sijhawm - txuas ntxiv thiab nrawm. Txhawm rau txiav txim siab yog tias koj xav tau txhaj tshuaj insulin ntev ntev thaum sawv ntxov, koj yuav tsum tau tshaib plab rau ib hnub thiab ua raws cov kev ua haujlwm ntawm cov ntshav qabzib hauv qib.

Kev txhaj tshuaj rau yav tsaus ntuj tsis tuaj yeem ncua sijhawm thaum sawv ntxov. Yog tias koj muaj cov piam thaj kom siab kawg thaum sawv ntxov nyob rau ntawm lub plab khoob, tsis txhob sim nws tua nws nrog qhov muaj peev xwm ntev ntawm cov tshuaj insulin ntev. Siv luv luv los yog ultrashort npaj rau qhov no.Nce koj cov koob tshuaj ntawm Lantus insulin thaum yav tsaus ntuj tom ntej. Txhawm rau kom muaj qab zib ib txwm nyob rau yav sawv ntxov ntawm lub plab khoob, koj yuav tsum tau noj hmo thaum ntxov - 4-5 teev ua ntej yuav mus pw. Txwv tsis pub, kev txhaj tshuaj ntev ntawm cov tshuaj insulin thaum hmo ntuj yuav tsis pab, txawm tias yuav tau siv ntau npaum li cas los xij.

Koj tuaj yeem nrhiav tau ntawm lwm qhov chaw yooj yim kev teeb tsa rau kev siv insulin Lantus dua li cov tau qhia. Raws li txoj kev pom zoo, nws raug pom zoo tias koj muab ib qho tshuaj ib hnub xwb.

Txawm li cas los xij, kev kho mob insulin yooj yim tsis ua haujlwm zoo. Tus kws kho ntshav qab zib uas siv lawv txom nyem los ntawm kev pheej cov ntshav qog ntshav qab zib thiab cov ntshav qab zib hauv cov ntshav qab zib. Sij hawm dhau mus, lawv txhim kho lub neej luv luv lossis hloov cov neeg mus rau tus neeg tsis taus. Yuav kom tswj tau tus mob ntshav qab zib hom 1 lossis hom 2 zoo, koj yuav tsum txuas ntxiv, kawm thiab ua dab tsi yog sau rau hauv.

Cov koob tshuaj ntau tshaj plaws ntawm Lantus insulin ib hnub yog dab tsi?

Tsis muaj ib qho kev tsim qauv uas tau tso cai ntau tshaj txhua hnub ntawm Lantus insulin. Nws raug nquahu kom nce nws kom txog thaum cov piam thaj hauv ntshav ntawm ntshav qab zib yog ntau dua lossis tsawg dua qub.

Hauv cov ntawv kho mob, cov neeg mob rog tus mob ntshav qab zib hom 2 uas tau 100-150 units ntawm cov tshuaj no ib hnub tau piav qhia. Txawm li cas los xij, ntau dua qhov noj txhua hnub, qhov teeb meem ntau dua ntawm cov tshuaj insulin.

Cov ntshav qabzib txuas ntxiv dhia, feem ntau muaj kev tawm tsam ntawm kev mob ntshav qab zib. Txhawm rau zam dhau cov teeb meem no, koj yuav tsum tau soj ntsuam thiab txhaj cov tshuaj insulin qis, uas sib haum rau nws.

Ib qho tsim nyog rau yav tsaus ntuj thiab thaum sawv ntxov ntawm Lantus insulin yuav tsum tau xaiv tus kheej. Nws txawv heev nyob ntawm lub hnub nyoog, lub cev qhov hnyav ntawm tus neeg mob thiab mob hnyav ntawm cov ntshav qab zib. Yog tias koj yuav tsum tau txhaj tshuaj ntau dua 40 units hauv ib hnub, ces koj tau ua qee yam tsis yog. Feem ntau cov yuav muaj, tsis yog nruj me ntsis ua raws li kev noj haus cov zaub mov carb qis. Los yog sim hloov cov kev txhaj tshuaj ntawm cov insulin ceev ua ntej noj mov nrog kev qhia ntawm kev txhaj tshuaj loj ntawm cov tshuaj glargine.

Kev rog tus neeg muaj ntshav qab zib hom 2 yuav raug nquahu kom tawm dag zog. Kev qoj ib ce yuav ua rau koj lub cev nkag mus rau insulin. Qhov no yuav ua rau nws muaj peev xwm faib nrog cov koob tshuaj sib daum. Nug seb Qi-khiav yog dab tsi.

Qee tus neeg mob feem ntau yuav rub tawm cov hlau hauv chaw ntaus kis las dua li dhia. Nws kuj pab.

Cov tshuaj insulin lantus thiab nws cov khoom sib txig sib luag. Daim ntawv thov rau cov xwm txheej tshwj xeeb thiab cov kab mob mus ntev

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Lauj Teeb Cov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Lantus hauv lawv qhov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Lantus analogues pom muaj cov qauv txheej txheem zoo. Siv rau kev kho mob ntawm ntshav qab zib insulin-mellitus rau cov laus, menyuam yaus, nrog rau thaum lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Lauj Teeb - yog ib qho tshuaj noj ntawm tib neeg cov tshuaj insulin. Tau los ntawm kev rov ua kom zoo ntawm cov kab mob DNA ntawm hom Escherichia coli (E. coli) (K12 hom). Nws muaj cov qis qis solubility hauv qhov nruab nrab tsis zoo. Nyob rau hauv kev sib xyaw ntawm cov tshuaj Lantus, nws yog soluble kiag li, uas tau xyuas los ntawm acidic ib puag ncig ntawm kev daws rau kev txhaj tshuaj (pH = 4). Tom qab kev qhia txog cov roj ntsha subcutaneous, kev daws teeb meem, vim nws cov acidity, nkag mus rau hauv kev cuam tshuam qhov nruab nrab nrog kev tsim cov microprecipitates, los ntawm cov tshuaj insulin glargine me me (cov tshuaj nquag ntawm Lantus kev npaj) tau tas li tso tawm, muab qhov ncaj (tsis muaj peaks) profile ntawm qhov nkhaus-sijhawm nkhaus, nrog rau ntev lub sijhawm ua haujlwm ntawm cov tshuaj.

Qhov khi khi txuas rau cov tshuaj insulin rau ntawm insulin glargine thiab insulin tib neeg yog qhov zoo heev.Glulin insulin muaj cov roj ntsha zoo ib yam li cov insulin endogenous.

Qhov kev txiav txim siab tseem ceeb tshaj plaws ntawm insulin yog kev cai ntawm kev ua haujlwm ntawm cov piam thaj. Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib los ntawm kev ua kom cov piam thaj los ntawm qhov nqaij (tshwj xeeb cov leeg pob txha thiab cov nqaij mos), nrog rau qhov ua kom cov ntshav qabzib nyob hauv lub siab (gluconeogenesis). Cov tshuaj insulin inhibits adipocyte lipolysis thiab proteolysis, thaum ua kom cov protein synthesis zoo.

Lub sijhawm ncua ntev ntawm kev ua ntawm insulin glargine yog ncaj qha vim nws qhov qis qis nqus, uas tso cai rau cov tshuaj siv ib hnub ib zaug. Qhov pib ntawm kev ua ntawm qhov nruab nrab yog 1 teev tom qab sc tswj hwm. Qhov nruab nrab ntawm kev nqis tes yog 24 teev, qhov siab tshaj yog 29 teev. Qhov xwm ntawm kev ua ntawm insulin thiab nws cov analogues (piv txwv li, insulin glargine) dhau sijhawm tuaj yeem sib txawv ob leeg hauv cov neeg mob sib txawv thiab hauv tib tus neeg mob.

Lub sijhawm ntawm cov tshuaj Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous.

Insulin glargine + excipients.

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab insulin-isophan tom qab kev coj noj coj ua hauv ntshav cov ntshav hauv cov neeg noj qab haus huv thiab cov neeg mob ntshav qab zib mellitus qhia txog kev nqus qis dua thiab tseem ntev dua, nrog rau qhov tsis muaj lub siab tshaj plaws hauv insulin glargine piv nrog insulin-isofan.

Nrog s / c tswj hwm ntawm cov tshuaj 1 zaug hauv ib hnub, qhov nruab nrab ruaj khov ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug.

Nrog kev tswj hwm intravenous, ib nrab-lub neej ntawm insulin glargine thiab tib neeg insulin yog qhov sib piv.

Hauv ib tus neeg nyob rau hauv cov roj ntsha subcutaneous, insulin glargine yog ib feem los ntawm carboxyl kawg (C-terminus) ntawm B saw (beta saw) tsim rau 21A-Gly-insulin thiab 21A-Gly-des-30B-Thr-insulin. Hauv ntshav, ob qho tib si tsis hloov pauv ntawm insulin glargine thiab nws cov khoom kom txav tau yooj yim.

mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj 6 xyoo,
mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj li 2 xyoos (rau SoloStar daim ntawv).

Kev daws rau kev tswj hwm subcutaneous (3 ml cartridges hauv OptiSet thiab OptiKlik syringe pens).

Ib qho kev daws teeb meem rau kev tswj hwm subcutaneous (3 ml cartridges hauv Lantus SoloStar syringe pens).

Cov lus qhia rau kev siv thiab tus qauv ntawm kev siv

Lantus OptiSet thiab OptiKlik

Qhov ntau npaum li cas ntawm cov tshuaj thiab lub sijhawm ntawm hnub rau nws cov kev tswj hwm tau teeb tsa ib leeg. Lantus siv tau subcutaneously ib hnub ib zaug, ib txwm nyob tib lub sijhawm. Lantus yuav tsum tau txhaj rau hauv cov roj hauv plab ntawm lub plab, xub pwg lossis ncej puab. Qhov chaw txhaj tshuaj yuav tsum tau hloov mus rau txhua txoj kev tswj hwm tshiab ntawm cov tshuaj hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj.

Cov tshuaj yuav siv tau ob qho tib si li monotherapy, thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic.

Thaum hloov mus rau tus neeg mob los ntawm insulins ntawm ntev lossis nruab nrab ntawm kev nqis tes ua rau Lantus, nws yuav tsim nyog los kho qhov tshuaj txhua hnub ntawm basal insulin lossis hloov cov tshuaj concomitant antidiabetic therapy (koob tshuaj thiab kev tswj hwm ntawm luv luv ua yeeb yam insulins lossis lawv cov analogues, nrog rau cov koob tshuaj ntawm qhov ncauj hypoglycemic).

Thaum hloov cov neeg mob los ntawm kev tswj hwm ob zaug ntawm insulin-isofan rau ib qho kev txhaj tshuaj ntawm Lantus, cov tshuaj txhua hnub ntawm basal insulin yuav tsum txo qis 20-30% hauv thawj lub lis piam ntawm kev kho mob kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab sawv ntxov. Nyob rau lub sijhawm no, qhov kev txo qis ntawm Lantus yuav tsum tau them nyiaj los ntawm kev nce ntxiv ntawm cov tshuaj insulin luv luv, tom qab ntawd los ntawm kev kho tus kheej rau cov koob tshuaj.

Ib yam li lwm yam tshuaj tiv thaiv kab mob rau tib neeg, cov neeg mob tau txais tshuaj ntau heev vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin tuaj yeem muaj qhov nce ntxiv ntawm cov lus teb rau insulin thaum hloov mus rau Lantus. Hauv cov txheej txheem hloov mus rau Lantus thiab hauv thawj lub lis piam tom qab nws, kev saib xyuas ntawm cov piam thaj hauv cov ntshav yog yuav tsum tau ua thiab, yog tias tsim nyog, kev kho ntawm kev tshaj tawm kev noj tshuaj ntawm insulin.

Nyob rau hauv cov ntaub ntawv ntawm kev txhim kho kev tswj ntawm cov metabolism thiab qhov tshwm sim ntau ntxiv hauv rhiab rau insulin, kev kho ntxiv ntawm kev siv tshuaj ntau dua tuaj yeem tsim nyog. Kev hloov kho koob tshuaj kuj tseem xav tau, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, lub sijhawm ntawm hnub rau kev tswj hwm tshuaj, lossis thaum muaj lwm yam tshwm sim uas ua rau muaj kev cuam tshuam rau kev txhim kho hypo- lossis hyperglycemia.

Cov tshuaj yuav tsum tsis txhob siv iv. Hauv / hauv kev qhia ntawm cov koob tshuaj ib txwm, npaj rau sc tswj hwm, tuaj yeem ua rau kev txhim kho ntshav nce siab ntau.

Ua ntej kev tswj hwm, koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj.

Cov kev cai siv thiab tuav ntawm cov tshuaj

Ua ntej OptiSet syringe Cwjmem

Ua ntej siv, tshawb xyuas daim cartridge sab hauv daim ntawv xaum. Nws yuav tsum siv tsuas yog hais tias qhov kev daws teeb meem yog pob tshab, xim, tsis muaj qhov pom ntawm cov khoom thiab thiab zoo sib xws, cuam tshuam nrog dej. Lub khoob OptiSet syringe cwjmem tsis yog coj los siv thiab yuav tsum tau muab pov tseg.

Txhawm rau tiv thaiv kev sib kis, tus cwj mem uas muaj puv xaum xaum xaum siv los siv rau ib tus neeg mob nkaus xwb thiab tsis tuaj yeem xa mus rau lwm tus neeg.

Kev tuav cov OptiSet Syringe Cwj mem

Rau txhua zaus siv tom qab, ib txwm siv rab koob tshiab. Tsuas siv cov koob haum rau OptiSet koob txhaj tshuaj.

Ua ntej txhua txoj kev txhaj tshuaj, txoj kev kuaj kev nyab xeeb yuav tsum ua tas li.

Yog tias OptiSet koob txhaj tshuaj tshiab siv, kev npaj txhij rau kev siv yuav tsum tau nqa tawm uas siv 8 ntu ua ntej xaiv los ntawm cov khw.

Lub koob tshuaj xaiv tsuas tuaj yeem tig ib qho hauv ib qho kev taw qhia nkaus xwb.

Tsis txhob tig cov koob tshuaj xaiv (hloov cov tshuaj) tom qab nias lub pob tshuaj txhaj.

Yog tias lwm tus muab kev txhaj tshuaj rau tus neeg mob, yuav tsum tau saib xyuas tshwj xeeb kom tsis txhob raug mob rab koob thiab kev kis kab mob kis los ntawm kev kis kab mob.

Tsis txhob siv cov OptiSet koob txhaj tshuaj puas, zoo li yog muaj neeg tsis ntseeg.

Nws yog qhov tsim nyog kom muaj lub ntsej muag OptiSet syringe cwj mem thaum poob lossis puas tsuaj rau qhov siv.

Tom qab hle lub hau tawm los ntawm tus cwj mem syringe, kuaj cov cim ntawm tus pas dej insulin kom paub tseeb tias nws muaj cov tshuaj insulin txoj cai. Cov tsos ntawm cov tshuaj insulin kuj yuav tsum raug kuaj xyuas: cov kua dej hauv cov kua dej yuav tsum ua kom pom tseeb, xim, tsis pom cov khoom tawg thiab muaj qhov sib xws li dej. Tsis txhob siv OptiSet syringe cwj mem yog cov kua dej hauv cov kua dej khov, muaj xim lossis muaj cov txawv txawv.

Tom qab hle lub hau, ua tib zoo muab txoj hlua khi rau ntawm rab koob txhaj tshuaj.

Txheeb xyuas qhov kev npaj txhij ntawm cov xaum xaum xaum rau kev siv

Ua ntej txhua txoj kev txhaj tshuaj, nws yog qhov yuav tsum tau xyuas qhov npaj txhij ntawm rab koob xaum rau kev siv.

Rau tus cwj mem tsis siv tshiab thiab tsis siv, qhov ntsuas qhov ntsuas yuav tsum nyob rau tus lej 8, raws li tau teev tseg los ntawm cov khw.

Yog tias siv tus cwj mem syringe, lub tshuab xa tawm yuav tsum tig kom txog thaum lub ntsuas qhov ntsuas nres ntawm tus lej 2. Lub tshuab xa tawm yuav tig raws tsuas yog ib qho kev taw qhia.

Rub tawm lub pob pib lub taub hau nkaus rau qhov tshuaj. Tsis txhob tig cov koob xaiv rau tom qab lub khawm pib rub tawm.

Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm. Khaws lub hau npog sab hauv kom tshem tawm cov siv tau siv.

Tuav tus xaum xaum nrog rab koob taw tes sau taw sab saud, maj mam npuaj lub npuaj insulin nrog koj tus ntiv tes kom cua npuas sawv ntawm rab koob.

Tom qab ntawd, nias pib khawm pib ntua.

Yog tias qhov poob ntawm insulin raug tso tawm ntawm qhov taub ntawm rab koob, koob txhaj tshuaj thiab koob ua haujlwm kom raug.

Yog tias qhov poob ntawm cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, koj yuav tsum rov ua qhov kev ntsuas tau npaj txhij ntawm rab koob xaum rau kev siv kom txog thaum cov insulin tshwm ntawm qhov taub ntawm rab koob.

Kev xaiv tshuaj insulin

Qhov koob tshuaj ntawm 2 units txog 40 units tuaj yeem tsim hauv nce ntxiv ntawm 2 units. Yog tias ib qho koob tshuaj ntau dua 40 units yuav tsum, nws yuav tsum raug txhaj nyob hauv ob lossis ntau dua kev txhaj tshuaj. Nco ntsoov tias koj muaj cov insulin txaus rau koj cov koob tshuaj.

Cov nplai ntawm cov tshuaj insulin nyob rau ntawm lub khob pob tshab rau cov tshuaj insulin qhia ntau npaum li cas cov tshuaj insulin nyob hauv OptiSet syringe cwj mem. Qhov ntsuas no tsis tuaj yeem siv los noj tshuaj insulin.

Yog hais tias lub piston dub yog thaum pib ntawm cov xim dawb lias, ces muaj kwv yees li 40 units ntawm insulin.

Yog hais tias lub qog dub yog qhov kawg ntawm cov kab dawb lias, tom qab ntawd muaj kwv yees li 20 units ntawm insulin.

Koob xaiv cov koob tshuaj yuav tsum tig kom txog rau thaum lub koob qhia tshuaj taw qhia yam xav tau.

Kev siv tshuaj insulin

Lub pob pib txhaj tshuaj yuav tsum tau rub mus rau hauv cov kev txwv sau cov insulin cwj mem.

Nws yuav tsum kuaj xyuas seb cov koob xav tau xav tau ntau ntau ntxiv. Lub pob pib hloov pauv raws li tus nqi ntawm cov tshuaj insulin seem hauv lub taub tshuaj insulin.

Lub pob pib tso cai rau koj los xyuas seb qhov tshuaj twg raug hu. Thaum qhov kev xeem, khawm pib yuav tsum tau ceev cia kom muaj zog. Qhov kawg pom ntawm cov kab dav ntawm lub khawm pib qhia txog tus nqi ntawm cov tshuaj insulin. Thaum pib khawm khawm, tsuas yog sab saum toj ntawm kab ntawv dav no pom.

Cov neeg qhia tshwj xeeb yuav tsum piav qhia txoj kev txhaj tshuaj rau tus neeg mob.

Lub koob txhaj yog txhaj subcutaneously. Lub pob pib txhaj tshuaj yuav tsum raug nias rau qhov txwv. Lub popping nyem yuav nres thaum txhaj pib pib nias rau txhua txoj kev. Tom qab ntawd, lub pob txhaj pib yuav tsum ceev rau hauv 10 vib nas this ua ntej rub rab koob tawm ntawm daim tawv nqaij. Qhov no yuav ua kom paub meej qhov pib ntawm tag nrho cov koob tshuaj insulin.

Tom qab txhua qhov kev txhaj tshuaj, rab koob yuav tsum tau muab tshem tawm ntawm koob txhaj tshuaj thiab muab pov tseg. Qhov no yuav tiv thaiv tus kab mob, nrog rau cov tshuaj insulin khiav tsis zoo, ua kom huab cua nkag tau thiab txhaws tau ntawm lub koob. Koob tsis tuaj yeem rov siv dua.

Tom qab ntawv, muab tso rau ntawm lub hau rau tus cwj mem syringe.

Cartridges yuav tsum tau siv ua ke nrog OptiPen Pro1 koob txhaj tshuaj, thiab raws li cov lus pom zoo los ntawm cov kws tsim khoom.

Cov lus qhia rau kev siv OptiPen Pro1 koob txhaj tshuaj hais txog lub thawv cartridge, kev sib txuas ntawm rab koob, thiab kev txhaj tshuaj insulin yuav tsum tau ua raws nraim. Tshawb xyuas daim cartridge ua ntej siv. Nws yuav tsum tau siv tsuas yog daws tau qhov tseeb, tsis muaj xim thiab tsis muaj cov khoom pom zoo. Ua ntej kev txhim kho lub taub hauv ntawv hauv lub phwj hauv cov thawv, yuav tsum tau ua daim cartridge yuav tsum nyob ntawm chav sov li 1-2 teev. Ua ntej txhaj, tshem cov pa npuas los ntawm daim cartridge. Nws yog ib qho tsim nyog yuav tau nruj me ntsis raws li cov lus qhia. Lub pob txha mos tas tsis rov qab siv dua. Yog tias OptiPen Pro1 syringe mem yog puas lawm, koj yuav tsum tsis txhob siv nws.

Yog tias rab koob xaum hluav taws xob muaj qhov yuam kev, yog tias tsim nyog, tshuaj insulin tuaj yeem muab rau tus neeg mob los ntawm kev sau cov tshuaj los ntawm daim cartridge rau hauv cov yas koob txhaj tshuaj (tsim nyog rau cov tshuaj insulin ntawm qhov siab ntawm 100 IU / ml).

Optical Nyem Cartridge System

Lub OptiClick cartridge system yog lub khob ntim uas muaj 3 ml ntawm insulin glargine tov, uas tau muab tso rau hauv cov pob tshab yas ntim nrog lub twj tso kua mis.

OptiClick cartridge system yuav tsum tau siv nrog OptiClick syringe cwj mem raws li cov lus qhia rau kev siv uas tuaj nrog nws.

Yog tias OptiClick syringe cwj mem puas lawm, hloov nws nrog tus tshiab.

Ua ntej kev txhim kho lub thawv ntim hauv OptiClick syringe mem, nws yuav tsum nyob ntawm chav tsev li 1-2 teev. Lub cartridge system yuav tsum kuaj xyuas ua ntej kev teeb tsa.Nws yuav tsum tau siv tsuas yog daws tau qhov tseeb, tsis muaj xim thiab tsis muaj cov khoom pom zoo. Ua ntej txhaj tshuaj, tshem cov pa npuas los ntawm daim cartridge system (zoo li yog siv rab koob xwj). Lub cav ntim cov nplauv tsis tau rov qab siv dua.

Yog tias rab koob xaum hluav taws xob muaj qhov yuam kev, yog tias tsim nyog, tshuaj insulin tuaj yeem muab rau tus neeg mob los ntawm kev ntaus cov tshuaj los ntawm daim cartridge rau hauv cov yas koob txhaj tshuaj (haum rau cov tshuaj insulin ntawm qhov siab ntawm 100 IU / ml).

Txhawm rau tiv thaiv kev kis mob, tsuas yog ib tus neeg yuav tsum siv tus cwj mem uas siv rov siv tau.

Lantus SoloStar yuav tsum tau txhaj tshuaj subcutaneously ib zaug hauv ib hnub ntawm txhua lub sijhawm ntawm hnub, tab sis txhua hnub nyob rau tib lub sijhawm.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus SoloStar tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic. Lub hom phiaj ntawm cov ntshav qab zib ntau, nrog rau cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm lossis kev tswj hwm ntawm cov tshuaj ntshav qog ntshav yuav tsum txiav txim siab thiab kho tus kheej.

Kev hloov kho koob tshuaj kuj tseem yuav tsum tau ua, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, hloov lub sijhawm ntawm kev saib xyuas ntawm lub koob tshuaj insulin, lossis lwm qhov xwm txheej uas yuav ua rau muaj kev cuam tshuam rau kev txhim kho hypo- lossis hyperglycemia. Txhua qhov kev hloov pauv ntawm cov koob tshuaj insulin yuav tsum tau ua nrog ceev faj thiab kev saib xyuas mob.

Lantus SoloStar tsis yog cov insulin ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv qhov no, kev nyiam yuav tsum tau muab rau hauv / hauv cov lus qhia ntawm luv luv ua yeeb yam insulin. Hauv cov txheej txheem kho mob suav nrog kev txhaj tshuaj insal basal thiab prandial insulin, 40-60% ntawm cov tshuaj insulin txhua hnub hauv daim ntawv ntawm insulin glargine feem ntau yog siv kom tau raws li qhov xav tau ntawm insulin basal.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus noj tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj, kev sib xyaw ua ke pib nrog ib koob tshuaj insulin glargine 10 PIECES 1 zaug hauv ib hnub thiab hauv kev kho mob tom ntej yog kho tus kheej.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic mus rau Lantus SoloStar

Thaum hloov cov neeg mob los ntawm cov txheej txheem kev kho mob uas siv cov tshuaj ntev nruab nrab lossis kev siv tshuaj ntev los rau kev kho mob uas siv Lantus SoloStar kev npaj, nws yuav tsim nyog kho tus naj npawb (koob tshuaj) thiab lub sijhawm ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin lossis nws cov tshuaj noj thaum nruab hnub lossis hloov cov tshuaj ntawm qhov ncauj hypoglycemic tshuaj.

Thaum hloov cov neeg mob los ntawm ib qho kev txhaj tshuaj ntawm cov tshuaj insulin-isofan nyob rau ib hnub rau ib txoj kev tswj hwm ntawm cov tshuaj thaum nruab hnub, Lantus SoloStar feem ntau tsis hloov pauv thawj zaug ntawm insulin (i.e., qhov ntau npaum li cas ntawm cov tshuaj Lantus SoloStar Cov Hnub ib hnub yog sib npaug nrog cov nyiaj ntawm ME insulin isofan ib hnub).

Thaum hloov cov neeg mob los ntawm kev siv tshuaj insulin-isophan ob zaug thaum nruab hnub rau ib qho kev txhaj tshuaj ntawm Lantus SoloStar ua ntej yuav mus pw kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab thaum sawv ntxov ntxov, qhov kev txhaj tshuaj insulin glargine txhua hnub feem ntau raug txo qis 20% (piv nrog qhov tshuaj ntawm txhua hnub ntawm insulin) isophane), thiab tom qab ntawd nws raug kho nyob ntawm lub teb ntawm tus neeg mob.

Lantus SoloStar yuav tsum tsis txhob sib xyaw lossis xyaw nrog lwm cov tshuaj insulin. Nco ntsoov tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj. Thaum muab sib xyaw los yog zom, qhov profile ntawm insulin glargine yuav hloov lub sijhawm.

Thaum hloov los ntawm tib neeg cov insulin rau Lantus SoloStar thiab thaum thawj lub lis piam tom qab nws, ua tib zoo saib xyuas kev ntsuas metabolic (saib xyuas cov ntshav qabzib hauv cov ntshav) nyob rau hauv kev saib xyuas mob tau pom zoo, nrog kev kho cov tshuaj ntau ntxiv ntawm cov insulin yog tias tsim nyog.Ib yam li lwm cov duab ntawm tib neeg cov tshuaj insulin, qhov no tshwj xeeb tshaj yog rau cov neeg mob, vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin, yuav tsum tau siv cov koob tshuaj ntau kawg ntawm tib neeg cov insulin. Hauv cov neeg mob no, thaum siv cov tshuaj insulin glargine, muaj kev txhim kho tseem ceeb rau cov tshuaj tiv thaiv kab mob insulin.

Nrog kev txhim kho metabolic kev tswj tau thiab qhov tshwm sim hauv kev hloov pauv nqaij hauv insulin mus rau insulin, nws yuav tsim nyog los kho qhov tshuaj ntau npaum li cas ntawm cov tshuaj insulin.

Kev sib xyaw thiab kev tsim tsiaj

Cov tshuaj Lantus SoloStar yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulins. Kev sib xyaw ua ke tuaj yeem hloov qhov sib piv ntawm lub sij hawm / siv cov tshuaj Lantus SoloStar, thiab tseem ua rau dej nag.

Cov pab pawg neeg tshwj xeeb

Cov tshuaj Lantus SoloStar tuaj yeem siv rau hauv cov menyuam yaus hnub nyoog ntau dua 2 xyoos. Siv rau cov menyuam yaus hnub nyoog qis dua 2 xyoos tsis tau kawm.

Hauv cov neeg laus cov neeg mob ntshav qab zib mellitus, nws raug nquahu kom siv cov koob tshuaj me ntsis, lawv qhov nce qeeb thiab siv cov koob tshuaj tiv thaiv mob pes tsawg.

Cov tshuaj Lantus SoloStar raug muab tshuaj ua ib qho sc txhaj tshuaj. Cov tshuaj Lantus SoloStar tsis yog tsim rau kev tswj hwm pob ntseg.

Lub sijhawm ntev ntawm kev ua ntawm insulin glargine yog pom tsuas yog thaum nws qhia rau hauv cov rog subcutaneous. Hauv / hauv kev qhia ntawm cov tshuaj subcutaneous li niaj zaus tuaj yeem ua rau mob ntshav qab zib heev. Lantus SoloStar yuav tsum tau nkag mus rau hauv cov roj ntsha hauv qab ntawm lub plab, xub pwg lossis lub duav. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv nrog txhua qhov kev txhaj tshuaj tshiab hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj. Xws li lwm hom tshuaj insulin, qhov siab ntawm kev nqus, thiab, yog li ntawd, qhov pib thiab lub sijhawm ntawm nws qhov kev ua, tuaj yeem sib txawv raws li tus yam ntxwv ntawm lub cev thiab lwm yam kev hloov pauv ntawm tus neeg mob lub cev.

Lantus SoloStar yog cov kev daws teeb meem, tsis raug ncua. Yog li ntawd, rov kho dua ua ntej siv tsis tas. Yog tias cov koob txhaj tshuaj Lantus SoloStar ua haujlwm tsis zoo, cov tshuaj insulin glargine tuaj yeem tshem tawm los ntawm daim cartridge mus rau hauv cov koob txhaj tshuaj (haum rau cov tshuaj insulin 100 IU / ml) thiab ua kom tsim nyog txhaj.

Cov cai rau siv thiab tuav ntawm cov ntawv ua ntej ua tiav cov kua mem SoloStar

Ua ntej siv thawj zaug, rab koob xaum xaum yuav tsum khaws cia ntawm chav tsev li 1-2 teev.

Lub cev tsis siv SoloStar lub koob txhaj tshuaj yuav tsum tsis txhob siv thiab muab pov tseg.

Txhawm rau tiv thaiv kev kis mob, tus cwj mem uas muaj menyuam qhwv ua ntej tsuas yog siv los ntawm ib tus neeg mob thiab yuav tsum tsis txhob hloov mus rau lwm tus.

Ua ntej siv SoloStar koob txhaj tshuaj, ua tib zoo nyeem cov ntaub ntawv ntawm kev siv.

Ua ntej siv txhua qhov, ua tib zoo txuas lub koob tshiab rau daim duab xaum xaum thiab kev sim kev nyab xeeb. Tsuas siv cov koob uas txuam nrog SoloStar yuav tsum siv.

Cov kev tiv thaiv tshwj xeeb yuav tsum tau ceev faj kom tsis txhob muaj kev sib tsoo nrog kev siv koob thiab qhov kis tau ntawm kev kis tus kab mob.

Tsis muaj qhov xwm txheej twg yog koj yuav tsum siv SoloStar syringe cwj mem yog tias nws puas lawm lossis yog tias koj tsis paub meej tias nws yuav ua haujlwm tau zoo.

Koj yuav tsum nco ntsoov muaj SoloStar koob txhaj tshuaj muaj nyob rau hauv yog tias poob lossis puas rau ib tus cwj mem SoloStar uas twb muaj lawm.

Yog tias SoloStar syringe cwj mem tau muab cia rau hauv lub tub yees, nws yuav tsum tau ua tawm 1-2 teev ua ntej qhov kev txhaj tshuaj kom cov tshuaj ua kom sov hauv chav. Kev tswj hwm cov tshuaj chine chilled yog qhov mob ntau dua. Kev siv SoloStar syringe cwj mem yuav tsum tau muab pov tseg.

SoloStar syringe mem yuav tsum muaj kev tiv thaiv los ntawm hmoov av thiab av.Sab sab nraud ntawm SoloStar koob txhaj tshuaj tuaj yeem muab ntxuav los ntawm kev so nws nrog daim ntaub ntub dej. Tsis txhob raus dej hauv cov kua, yaug thiab ntub dej SoloStar syringe cwj mem, vim tias qhov no tuaj yeem ua rau nws puas.

SoloStar koob txhaj tshuaj yog txhaj tshuaj insulin kom raug thiab nyab xeeb siv. Nws tseem yuav tsum tau ua tib zoo saib xyuas. Zam cov xwm txheej uas ua puas rau SoloStar koob txhaj tshuaj yuav tshwm sim. Yog tias koj xav tias muaj kev puas tsuaj rau SoloStar syringe cwj mem uas twb muaj lawm, siv tus xaum xim tshiab.

Theem 1. Tshuaj Insulin

Koj yuav tsum kos cov ntawv lo rau ntawm SoloStar syringe cwj mem kom ntseeg tau tias nws muaj cov tshuaj insulin txoj cai. Rau Lantus, SoloStar koob txhaj tshuaj yog grey nrog lub khawm xiav rau txhaj. Tom qab hle lub hau ntawm rab koob txhaj tshuaj, cov tsos ntawm cov tshuaj insulin nyob hauv nws yog tswj: cov tshuaj insulin yuav tsum muaj pob tshab, tsis muaj xim, tsis muaj cov khoom ua kom pom thiab zoo li dej nyob hauv xwm yeem.

Theem 2. Txuas rab koob

Tsuas yog siv cov koob uas txuam nrog SoloStar koob txhaj tshuaj yuav tsum tau siv. Txog kev txhaj txhua zaus, yuav tsum siv rab koob tshiab tshiab uas tsis huv. Tom qab hle lub hau tawm, rab koob yuav tsum tau muab ntsia kom zoo ntawm daim duab syringe.

Theem 3. Ua qhov ntsuas kev nyab xeeb

Ua ntej txhua txoj kev txhaj tshuaj, nws yog qhov yuav tsum tau ua qhov kev ntsuas kev nyab xeeb thiab ua kom cov koob txhaj tshuaj ua haujlwm zoo thiab cua tshuab tau tshem tawm.

Ntsuas ib koob tshuaj sib npaug rau 2 ntsuas.

Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm.

Muab tus cwj mem ntim nrog rab koob tso tawm, maj mam coj mus rhaub cov insulin lub taub hau nrog koj tus ntiv tes kom txhua npuas pa mus rau rab koob.

Tag nrho nias lub pob txhaj.

Yog tias muaj cov tshuaj insulin rau ntawm qhov kawg ntawm rab koob, qhov no txhais tau tias rab koob xaum thiab rab koob ua hauj lwm zoo.

Yog tias cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, tom qab ntawd cov kauj ruam 3 tuaj yeem rov ua dua kom txog thaum insulin tshwm ntawm lub taub ntawm rab koob.

Theem 4. Xaiv Xaiv

Cov koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm 1 unit los ntawm koob tshuaj yam tsawg kawg nkaus (1 units) txog qhov siab tshaj plaws (80 units). Yog tias nws yog qhov yuav tsum tau qhia qhov tshuaj tshaj li ntawm 80 units, yuav tsum txhaj 2 lossis ntau dua kev txhaj tshuaj.

Lub khob ntim tshuaj yuav tsum qhia "0" tom qab kev ntsuas kev nyab xeeb tiav. Tom qab ntawd, cov koob tshuaj tsim nyog tau tsim muaj.

Theem 5. Ceeb Toom

Tus neeg mob yuav tsum tau qhia rau cov txheej txheem txhaj tshuaj los ntawm tus kws kho mob paub.

Lub koob yuav tsum tau muab tso rau hauv qab daim tawv nqaij.

Lub pob txhaj tshuaj yuav tsum nias tag nrho. Nws tau tuav hauv txoj haujlwm no rau 10 feeb ntxiv kom txog thaum muab rab koob tshem tawm. Qhov no ua kom paub tseeb ntawm qhov kev xaiv ntawm xaiv koob tshuaj insulin kiag li.

Theem 6. Tshem thiab tshem tawm ntawm rab koob

Txhua qhov xwm txheej, rab koob tom qab txhua txoj kev txhaj tshuaj yuav tsum tau muab tshem tawm thiab muab pov tseg. Qhov no ua kom muaj kev tiv thaiv ntawm kev sib kis thiab / lossis kis tau tus mob, cua nkag mus rau hauv lub thawv rau tshuaj insulin thiab paim ntshav ntawm insulin.

Thaum hle thiab pov tseg lub koob, yuav tsum muaj kev tiv thaiv tshwj xeeb. Ua raws li kev tiv thaiv kev nyab xeeb pom zoo kom tshem tawm thiab ntuav tawm rab koob (piv txwv, cov txheej txheem tes ib leeg) txhawm rau txo kev pheej hmoo ntawm kev phom sij ntsig txog rab koob thiab tiv thaiv ua mob.

Tom qab hle rab koob, kaw lub SoloStar syringe cwj mem nrog lub hau.

hypoglycemia - muaj kev txhim kho feem ntau yog tias cov koob tshuaj insulin ntau dua qhov xav tau rau nws,
"twilight" nco qab lossis nws poob,
mob huam
kev tshaib kev nqhis
txob taus
hws no
tachycardia
pom kev pom
retinopathy
ua yeeb yaj kiab
mob siab,
myalgia
o tuaj
cov tshuaj tiv thaiv tam sim ntawd rau tshuaj insulin (suav nrog insulin glargine) lossis cov tshuaj tiv thaiv cov tshuaj: cov tawv nqaij tsis haum rau lub cev, cov tshuaj tiv thaiv mob hlwb, mob ntsws, mob ntsws, mob ntshav hauv lub plawv, poob siab,
liab, mob, khaus, khaus, o lossis o ntawm thaj chaw txhaj tshuaj.

cov me nyuam qis dua 6 xyoo rau Lantus OptiSet thiab OptiKlik (tam sim no tsis muaj cov ntaub ntawv tshawb fawb txog kev siv),
cov menyuam yaus lub hnub nyoog txog 2 xyoos rau Lantus SoloStar (tsis muaj cov ntaub ntawv tshawb fawb txog kev siv),
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Nrog kev ceev faj, Lantus yuav tsum siv thaum cev xeeb tub.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj cov kev cai metabolic txaus thoob plaws lub cev xeeb tub. Hauv lub caij nyoog thib ib ntawm cev xeeb tub, xav tau cov tshuaj insulin yuav txo qis, hauv kev txiav thib 2 thiab thib 3 nws yuav nce ntxiv. Tam sim ntawd tom qab yug menyuam tas, xav tau cov tshuaj insulin tsawg dua, thiab yog li qhov kev pheej hmoo ntawm kev mob ntshav qab zib nce ntxiv. Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Hauv kev sim tsiaj, tsis muaj cov ntaub ntawv ncaj qha los yog tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine.

Tseem tsis tau muaj kev tswj hwm qhov kev soj ntsuam ntawm kev nyab xeeb ntawm cov tshuaj Lantus thaum cev xeeb tub. Muaj pov thawj ntawm kev siv Lantus hauv 100 tus poj niam cev xeeb tub muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin.

Rau cov poj niam thaum lub sijhawm pub niam mis, yuav tsum muaj kev kho mob ntawm cov tshuaj insulin kom zoo thiab kev noj zaub mov kom zoo.

Siv rau menyuam yaus

Tam sim no tsis muaj cov ntaub ntawv tshawb fawb txog kev siv hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Siv rau cov neeg mob laus

Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum kev ua haujlwm tuaj yeem ua rau txo cov tshuaj insulin tsis tu ncua.

Lantus tsis yog cov tshuaj ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv cov xwm txheej zoo li no, kev pom zoo ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin.

Vim tias qhov kev siv tsawg nrog Lantus, nws tsis muaj peev xwm los soj ntsuam nws cov hauj lwm zoo thiab kev nyab xeeb hauv kev kho cov neeg mob uas lub siab tsis ua hauj lwm lossis cov neeg mob uas tsis txaus los yog lub raum tsis txaus.

Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov ua kom tsis muaj zog ntawm nws cov txheej txheem tshem tawm. Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum kev ua haujlwm tuaj yeem ua rau txo cov tshuaj insulin tsis tu ncua.

Hauv cov neeg mob uas muaj kev tiv thaiv kabmob hepatic txaus, qhov kev xav tau rau insulin tuaj yeem raug txo vim muaj kev txo qis hauv kev muaj peev xwm gluconeogenesis thiab biotransformation ntawm insulin.

Kev tswj hwm qhov tsis zoo ntawm cov theem ntawm cov piam thaj hauv cov ntshav, zoo li yog tias muaj kev nyiam los txhim kho hypo- lossis hyperglycemia, ua ntej taug kev nrog kev txhim kho ntawm kev noj tshuaj, nws yog qhov yuav tsum tau kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem kev kho mob, qhov chaw ntawm kev tswj hwm tshuaj thiab cov txheej txheem ntawm kev tsim nyog sc txhaj tshuaj. , xav txog txhua yam cuam tshuam rau nws.

Lub sijhawm ntawm kev txhim kho hypoglycemia yog nyob ntawm qhov profile ntawm kev ua ntawm kev siv tshuaj insulin thiab yuav, yog li ntawd, hloov nrog qhov hloov pauv ntawm kev kho mob. Vim tias qhov nce ntxiv hauv lub sijhawm nws yuav siv rau kev tswj hwm ntawm cov insulin ntev ntev thaum siv Lantus, ib qho yuav tsum cia siab tias yuav muaj qhov qis dua ntawm kev txhim kho nocturnal hypoglycemia, thaum ntxov thaum lub sijhawm sawv ntxov qhov kev cia siab yuav siab dua. Yog tias hypoglycemia tshwm sim hauv cov neeg mob tau txais Lantus, muaj peev xwm ua rau kev tawm qeeb los ntawm hypoglycemia vim yog lub sijhawm ntev ua ntawm insulin glargine yuav tsum raug txiav txim siab.

Hauv cov neeg mob uas ua rau lub sijhawm mob ntshav qab zib tsawg yuav muaj tej yam tseem ceeb hauv kev soj ntsuam, suav nrog nrog kev mob hnyav ntawm cov hlab ntshav ntawm lub plawv lossis cov hlab ntsha hauv hlab ntsha (muaj kev pheej hmoo ntawm kev mob plawv thiab cov ntshav ntawm lub qog ntshav qab zib), nrog rau cov neeg mob uas muaj kev phom sij loj dua, tshwj xeeb tshaj yog tias lawv tsis tau txais kev kho mob photocoagulation (muaj kev pheej hmoo tsis pom kev vim tias muaj ntshav qab zib), yuav tsum tau ceev faj tshwj xeeb ntshav qab zib.

Cov neeg mob yuav tsum tau ceeb toom txog cov xwm txheej uas cov tsos mob ua ntej ntawm lub qog ntshav qab zib yuav txo qis, tsis hais tawm los yog tsis tuaj rau hauv qee pawg muaj kev pheej hmoo, uas suav nrog:

cov neeg mob uas tau pom muaj kev hloov kho cov kev cai ntawm cov ntshav piam thaj,
cov neeg mob uas mob ntshav qab zib tsawg zuj zus
cov neeg laus laus
cov neeg mob neuropathy
cov neeg mob uas muaj ntshav qab zib ntev,
cov neeg mob mob hlwb
cov neeg mob hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg insulin,
cov neeg mob tau txais kev kho mob nrog lwm yam tshuaj.

Cov xwm txheej zoo li no tuaj yeem ua rau muaj kev nce siab ntawm qhov mob ntshav qab zib tsawg (nrog rau qhov ua rau tsis nco qab) ua ntej tus neeg mob paub tseeb tias nws muaj kev mob ntshav qab zib tsawg.

Yog tias muaj qhov qis lossis qis glycated hemoglobin qib raug sau tseg, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej muaj peev xwm tsim rov tshwm sim tsis paub lub sijhawm ntawm hypoglycemia (tshwj xeeb tshaj yog thaum tsaus ntuj).

Cov neeg mob ua raws li kev noj tshuaj, kev noj haus, thiab kev noj haus, kev siv tshuaj insulin kom raug, thiab tswj kev pib ntawm cov tsos mob ntawm lub qog ntshav qab zib ua rau txo qis tseem ceeb ntawm qhov kev pheej hmoo ntawm hypoglycemia. Nyob rau hauv lub xub ntiag ntawm yam uas ua rau kom cov kev xav rau lub cev tsis zoo, tshwj xeeb tshaj yog saib xyuas yog qhov tsim nyog, vim hais tias Yuav tsum tau txhaj tshuaj insulin ntau npaum li cas. Tej yam no suav nrog:

hloov chaw ntawm kev tswj hwm ntawm insulin,
nce rhiab rau insulin (piv txwv li, thaum tshem tawm cov kev ntxhov siab),
txawv txav, nce lossis ntev heev ntawm kev ua lub cev,
cov kab mob sib xyaw nrog los ntuav, raws plab,
ua txhaum kev noj haus thiab kev noj haus,
hla kev noj haus
haus cawv
qee qhov ua tsis tiav ntawm cov tshuaj endocrine (piv txwv li, hypothyroidism, tsis txaus ntawm adenohypophysis lossis adrenal cortex),
muaj kev sib txuam nrog lwm yam tshuaj.

Hauv cov kabmob uas cuam tshuam, yuav tsum muaj kev tswjhwm ntau dua ntawm cov ntshav piam thaj. Feem ntau, kev txheeb xyuas yog ua rau muaj cov ketone lub cev nyob hauv cov zis, thiab kev kho ntawm cov tshuaj ntau npaum li cas ntawm cov tshuaj insulin kuj tseem xav tau. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob ntshav qab zib hom 1 yuav tsum txuas ntxiv kev haus tsawg kawg, txawm tias noj tsawg tsawg txawm muaj tsawg los sis tsis muaj peev xwm noj, nrog rau ntuav. Cov neeg mob no yuav tsum tsis txhob tso tseg txoj kev siv tshuaj insulin.

Cov tshuaj tiv thaiv kab mob rau hauv lub cev, ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, dextropropoxyphene, salicylates thiab sulfonamide antimicrobials tuaj yeem txhim kho hypoglycemic nyhuv ntawm insulin thiab nce qhov kev txhawb nqa rau kev txhim kho hypoglycemia. Nrog rau cov kev sib txuas ua ke no, yuav tsum tau muaj kev kho kom haum ntawm cov tshuaj insulin glargine.

Glucocorticosteroids (GCS), danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, phenothiazine derivatives, somatotropin, sympathomimetics (e.g. epinephrine, salbutamol, terbutaline), cov thyroid hormones, clintazepine inhibitors, qee yam ) tej zaum yuav txo cov nyhuv hypoglycemic ntawm insulin.Nrog rau cov kev sib txuas ua ke no, yuav tsum tau muaj kev kho kom haum ntawm cov tshuaj insulin glargine.

Nrog tib lub sijhawm siv cov tshuaj Lantus nrog cov beta-blockers, clonidine, lithium ntsev, ethanol (cawv), ob qho tib si ntxiv dag zog thiab qaug zog ntawm cov nyhuv hypoglycemic ntawm insulin yog ua tau. Pentamidine thaum ua ke nrog cov tshuaj insulin tuaj yeem ua rau hypoglycemia, uas yog qee zaum hloov los ntawm hyperglycemia.

Nrog rau kev siv ua ke nrog cov tshuaj nrog cov nyhuv sympatholytic, xws li beta-blockers, clonidine, guanfacine thiab reserpine, qhov txo qis lossis tsis muaj cov cim ntawm adrenergic counterregulation (kev ua kom zoo ntawm cov leeg hlwb) nrog kev txhim kho hypoglycemia yog ua tau.

Daim roj pleev tsis tas yuav tsum muab sib xyaw nrog lwm cov tshuaj insulin, nrog rau lwm yam tshuaj, lossis diluted. Thaum muab sib xyaw los yog zom, qhov profile ntawm nws qhov kev txiav txim siab yuav hloov zuj zus, ntxiv rau, kev sib xyaw nrog lwm cov insulins tuaj yeem ua rau nag lossis daus.

Cov tshuaj ntawm cov tshuaj Lantus

Cov qauv ntawm cov qauv ua haujlwm:

Tshuaj insulin glargine,
Xaus SoloStar.

Cov tshuaj piv rau qhov ua kom ua tau zoo (tshuaj rau kev kho mob ntawm cov tshuaj ntshav qab zib insulin mellitus):

Actrapid
Tus tub sab
Apidra
B. TshuajTus Kab
Berlinulin,
Biosulin
Glyformin
Glucobay,
Qov tshuaj insulin C,
Dibikor
Isofan Insulin Ntiaj Teb Khob,
Iletin
Tshuaj Insulin Isofanicum,
Cov ntaub thaiv insulin,
Tshuaj insulin Maxirapid B,
Insulin soluble nruab nrab
Insulin semilent,
Cov tshuaj Insulin Ultralente,
Cov tshuaj insulin ntev
Tshuaj insulin Ultralong,
Neeg tsis ntseeg xav
Mob siab
Siv cov tshuaj insulin C
Levemir Penfill,
Levemir Flexpen,
Metformin
Mikstard
Monosuinsulin MK,
Monotard
NovoMiks,
NovoRapid,
Pensulin,
Protafan
Rinsulin
Tshuaj Stylamine
Torvacard
Tricor
Ntshaw Txiv Neej
Neej Neeg,
Neeg lim hiam
Cigapan
Erbisol.

Thaum tsis muaj cov tshuaj analogues rau cov tshuaj rau cov tshuaj yeeb dej caw, koj tuaj yeem nyem rau ntawm qhov txuas hauv qab no rau cov kab mob uas cov tshuaj tsim nyog pab los ntawm thiab pom muaj cov analogues rau kev kho mob nyhuv.

Nyeem cov lus teb rau cov lus nug:

Cov insulin ntev ntev: cov ncauj lus ntxaws ntxaws

Kev siv cov tshuaj Lantus

S / c siv tau rau thaj av ntawm thaj chaw sab xub ntiag phab ntsa, deltoid leeg lossis ncej puab ib zaug ib hnub, tib lub sijhawm. Cov koob tshuaj tau teeb tsa ib tus zuj zus. Txhawm rau tswj hwm cov tshuaj, tsuas yog cov koob txhaj tshuaj kawm tiav ntawm 100 IU yuav tsum raug siv! Lantus tsis tuaj yeem nkag rau hauv / hauv, txij li qhov qhia txog hauv kev siv tshuaj ib txwm rau sc tswj hwm tuaj yeem ua rau muaj kev txhim kho ntshav nce siab ntau. Lub lantus yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin lossis diluted, vim tias qhov no tuaj yeem hloov lub sijhawm / xwm txheej ntawm cov tshuaj thiab ua rau muaj kev tsim cov txo.
Hauv cov neeg mob uas muaj mob ntshav qab zib hom mob mellitus, Lantus tuaj yeem siv ua ke nrog cov tshuaj tiv thaiv qhov ncauj hypoglycemic, qhov no, qhov pib nruab nrab ntawm Lantus yog 10 IU / hnub, los ntawm 2 txog 100 IU / hnub.
Hloov los ntawm lwm cov insulin. Thaum hloov los ntawm cov kua dej los ntawm qhov nruab nrab ntawm kev ua haujlwm ntev los yog los ntawm cov insulin ntev mus rau Lantus, tej zaum yuav xav tau kev kho kom haum ntawm cov tshuaj insulin basal, nrog rau kev hloov pauv ntau npaum li cas ntawm cov tshuaj tiv thaiv kab mob hypoglycemic qhov ncauj, luv luv ua yeeb yam insulin analogues.
Txhawm rau kom txo qis qhov mob nocturnal hypoglycemia lossis hypoglycemia thaum sawv ntxov ntxov, cov neeg mob uas tau hloov los ntawm ob zaug tswj tib neeg cov tshuaj insulin rau Lantus ib hnub ib zaug yuav tsum tau txo qis ntawm cov tshuaj insulin los ntawm 20-30% nyob rau thawj lub lim tiam ntawm kev kho mob. Xws li qhov txo qis hauv cov koob tshuaj insulin yuav tsum tau txiav txim siab ib ntus los ntawm qhov nce hauv cov koob tshuaj insulin uas muab nrog zaub mov. Thaum kawg ntawm lub sijhawm npaj, qhov tshuaj ntawm cov tshuaj insulin raug kho dua.
Ib yam li lwm yam tshuaj insulin, nyob rau hauv cov neeg mob uas tau txais insulin siab vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin, nws muaj peev xwm txhim kho cov lus teb rau insulin thaum kho nrog Lantus SoloStar, uas yuav tsum tau txhaj tshuaj kho. Qhov no yog qhov tshwj xeeb tshaj yog xav txog hauv cov neeg mob rog nrog kev rog dhau los, nrog kev hloov pauv ntawm txoj kev ua neej.
Lantus muab rau s / c 1 zaug nyob rau ib hnub, tib lub sijhawm, hauv kev xaiv tus kheej.
Lub koob txhaj tshuaj tso cai rau koj nkag mus rau cov tshuaj hauv qhov ntau ntawm ib koob tshuaj txij li 2 txog 40 IU. Cov tshuaj tsis tuaj yeem nkag mus rau hauv / hauv, txij li qhia txog kev siv tshuaj ib txwm muaj hauv qhov no tuaj yeem ua rau muaj kev txhim kho ntshav khov.
Tsis muaj qhov sib txawv hauv qhov chaw kho mob nyob rau hauv cov ntshav ntshav lossis ntshav qab zib tom qab kev siv tshuaj mus rau sab xub ntiag phab ntsa, deltoid cov leeg lossis ncej puab. Qhov chaw txhaj tshuaj tuaj yeem hloov mus rau hauv lub voj voog.
Nws yog qhov ua tau los thov cov tshuaj tsuas yog tias txoj kev daws teeb meem thaum kuaj qhov muag pom yog pob tshab thiab tsis muaj xim (los yog xyaum xim), tsis muaj qhov pom tau pom ntawm qhov muag. Ua ntej txhaj tshuaj, tshem tawm cov pa npuas los ntawm koob txhaj tshuaj. Kev sib xyaw cov tshuaj nrog lwm tus neeg sawv cev tsis raug tso cai, vim tias qhov no yuav ua rau kev tsim cov dej nag lossis daus. Txhua zaus ua haujlwm rau kev txhaj tshuaj, siv cov koob tshiab rau txoj phuam txhaj tshuaj. Tom qab txhaj tshuaj, cov koob yuav tsum tau muab tshem tawm thiab cov xias xaum qhwv cia yam tsis muaj rab koob.
Tsis tas yuav co tus cwj mem ua ntej siv. Ua ntej siv, koob txhaj tshuaj yuav tsum tau tuav li 1-2 teev ntawm chav sov.
Txhawm rau txhawm rau muab rab koob, tshem daim paib tiv thaiv los ntawm rab koob koob ntim uas tsis thawm tshem lub hau thiab sab nraud ntawm rab koob. Ua tib zoo txuas lub koob nrog nws lub hau sab nraud kom meej rau lub pob tshab dej (los ntawm kev siv ntsia hlau rau hauv los yog nias, nyob ntawm seb hom koob). Tsis txhob tso lub koob ntawm lub kaum ntse ntse, vim tias qhov no yuav ua rau nws tawg lossis insulin kom xau tawm ntawm lub system thiab ua rau kom tsis raug raws cai. Thaum muab cov ntawv, tsis txhob nias lub pob ntau dhau. Koj yuav tsum paub tseeb tias txhaj tshuaj khawm nias.
Ua ntej txhua txoj kev txhaj tshuaj, txoj kev kuaj kev nyab xeeb yuav tsum ua. Rau qhov ntsuas kev nyab xeeb thawj zaug, koob tshuaj yuav tsum yog 8 units ntawm insulin thaum siv tus cwj mem tsis siv tshiab yav tas los. Nco ntsoov tias qhov ntsuas lub koob tshuaj qhia tus lej 8. Yog tias qhov no tsis yog, siv cwj mem tshiab ntxiv. Ncua lub pob tshuaj kom ntau li ntau tau. Tsis txhob xa daim ntawv siv tshuaj rov qab yog tias lub khawm koob rho tawm.
Txog rau tus cwj mem uas twb siv lawm, muab lub koob tshuaj qhia rau tus naj npawb 2 los ntawm kev hloov lub ntsuas hluav taws xob. Lub tshuab hluav taws xob metering tuaj yeem tig rau txhua qhov kev coj. Rub tawm lub koob tshuaj khawm. Kuaj xyuas yog tias tus lej ntawm lub pob sib tw nrog cov koob tshuaj uas xaiv hauv lub koob tshuaj hloov. Dub txaus ntshai qhia tus lej ntawm cov ntsuas.Lub npov kawg kawg pom ntawm lub pob (tsuas yog nws sab saud yog pom) qhia qhov siv tau them. Txhawm rau pom daim ntawv kawg tuab, koj tuaj yeem tig los yog khoov rau lub xaum xaum npuav.
Tshem lub hau ntawm sab hauv thiab sab nraud. Tuav tus cwj mem syringe nrog rab koob nce, nws yog qhov yooj yim rau coj mus rhaub cov thawv nrog tshuaj insulin nrog koj lub ntsis ntiv tes kom cua npuas sawv nyob rau hauv cov kev taw qhia ntawm rab koob. Nias lub koob tshuaj khawm txhua txoj kev tso tawm qhov koob tshuaj. Hauv qhov no, koj tuaj yeem xav tias qhov nias uas yuav nres tom qab lub pob tshuaj tau nias tag nrho. Yog tias cov tshuaj insulin tshwm ntawm qhov taub ntawm rab koob, lub cuab yeej ua haujlwm zoo. Yog tias cov tshuaj insulin tsis tshwm sim li lub hau ntawm rab koob, rov hais cov lus qhia saum toj no. Yog tias poob ntawm cov tshuaj insulin tsis tshwm sim txawm tias rov kuaj qhov kev nyab xeeb dua, tshawb xyuas cov cuab yeej rau cov cua npuas. Yog tias muaj, rov ua qhov ntsuas kev nyab xeeb kom txog thaum lawv ploj. Thaum tsis muaj huab cua ua npuas, lub koob yuav dhau los txhaws, nyob rau hauv rooj plaub twg nws yuav tsum tau hloov.
Tom qab nkag rau ntawm rab koob, nias lub khawm koob tshuaj txhua txoj kev. Tso tawm rab koob rau hauv daim tawv nqaij tsawg kawg 10 vib nas this. Lub koob tshuaj yuav tsum nyob twj ywm kom txog thaum lub koob tshem tawm. Tom qab tshem tawm, rab koob yog unscrewed los ntawm tig lub hau. Lub koob tau tsuas yog siv ib zaug xwb.
Kev Soj ntsuam lub tank rau Insulin Residue
Cov ntsuas ntawm lub pob tshab ua kom pom tseeb qhia tus nqi ntawm cov tshuaj insulin ntxiv rau hauv cov xaum qhuav. Qhov ntsuas no tsis yog los txiav txim siab qhov koob tshuaj ntawm insulin. Yog tias lub piston dub nyob ze rau qhov cim 40 thaum pib nres xim, qhov no txhais tau tias qhov seem ntawm cov tshuaj insulin hauv cov xaum xaum yog kwv yees li 40 IU. Qhov kawg ntawm qhov nres nres tau qhia tias tus cwj mem muaj kwv yees li 20 IU ntawm cov tshuaj insulin. Nrog rau theem qis ntawm cov insulin hauv lub tank, koj tuaj yeem tshawb xyuas nws lub xub ntiag siv lub koob txhaj tshuaj.
Tsis txhob siv tus cwj mem yog tias koj tsis paub meej tias muaj cov tshuaj insulin txaus rau qhov koob tshuaj ntxiv. Piv txwv, yog tias qhov ntsuas qhov ntsuas tau teeb tsa ntawm 30 IU, tab sis lub koob txhaj tshuaj raug rub tawm tsis tshaj 12 IU, qhov no txhais tau hais tias tsuas yog 12 IU ntawm insulin tuaj yeem raug txhaj nrog qhov xaum xaum no. Hauv qhov no, qhov ploj mus 18 IU tuaj yeem raug qhia siv siv tus cwj mem tshiab los yog siv tus cwj mem tshiab los tswj cov tshuaj puv ntawm 30 IU ntawm cov tshuaj insulin.

Phiv los ntawm yeeb tshuaj Lantus

Kev mob ntshav siab yog qhov teeb meem uas ib txwm muaj nyob hauv kev kho mob ntawm insulin (tshwj xeeb tshaj yog thaum siv ntau kawg). Kev mob ntshav khov ntau heev tuaj yeem ua rau lub paj hlwb tsis zoo thiab yog qhov txaus ntshai rau tus neeg mob lub neej. Cov kev mob tshwm sim hauv qab no uas tau pom thaum lub sijhawm kuaj mob ntawm kev siv cov tshuaj tau nthuav tawm rau hauv cov kab mob hauv lub cev thiaj li yuav txo cov zaus ntawm lawv cov kev ua kom pom (ntau zaus 1/10, feem ntau 1/100, tab sis ≤1 / 10, tsis tshua muaj 1/1000, tab sis ≤ 1/100, tsis tshua muaj tshwm sim - 1/10000, tab sis ≤1 / 1000, qee zaum ≤1 / 10000) thiab txo qhov tseem ceeb.
Los ntawm sab ntawm cov metabolism: heev feem ntau - hypoglycemia. Kev mob ntshav qis heev, tshwj xeeb tshaj yog rov ua dua, tuaj yeem ua rau kev puas tsuaj rau cov hlab ntsha tawg. Cov ntshav qog ntshav ntev lossis ntshav hnyav tuaj yeem tsim kev tuag taus. Hauv ntau cov neeg mob, cov tsos mob ntawm kev mob ntshav qab zib yog ua ntej los ntawm cov tsos mob ntawm adrenergic counterregulation (ua kom cov mob sympathoadrenal ua teb rau hypoglycemia), qhov ntau thiab ntau dua sai sai ntshav plasma txo qis, cov cim qhia tau ntau ntxiv ntawm kev tawm tsam.
Los ntawm lub nruab zog: tsis tshua muaj - kev ua xua tshwm sim. Qee zaum cov kev tsis haum ntawm cov hom tam sim rau insulin loj hlob. Cov kev xav zoo li no rau cov tshuaj insulin (suav nrog insulin glargine) lossis rau cov tshuaj ntawm cov tshuaj (cov tshuaj tiv thaiv tawv nqaij thoob plaws, mob caj dab, bronchospasm, hypotension thiab kev poob siab) tuaj yeem hem tus neeg mob lub neej.
Kev siv cov tshuaj insulin tuaj yeem ua rau cov tsos ntawm cov tshuaj tiv thaiv rau nws.Hauv qhov kev tshawb fawb soj ntsuam, hla kev tsim cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin thiab insulin glargine tau qhia tawm. Lub xub ntiag ntawm cov tshuaj tiv thaiv rau cov tshuaj insulin tej zaum yuav xav tau hloov kho koob tshuaj.
Ntawm qhov txhia chaw: tsis tshua muaj heev - dysgeusia.
Los ntawm sab ntawm cov khoom ntawm lub zeem muag: tsis tshua pom - pom qhov tsis taus. Kev hloov pauv ntawm cov ntshav qab zib hauv cov ntshav plasma tuaj yeem ua rau pom kev tsis pom kev ib ntus vim yog kev hloov me ntsis hauv turgor thiab qhov cuam tshuam ntawm lub lens ntawm lub qhov muag. Kev tsis pom kev cuam tshuam yog txuam nrog kev tsis hnov qab lub zog.
Tsis tshua muaj, retinopathy. Txuas ntxiv txhim kho hauv glycemia txo txoj kev pheej hmoo ntawm kev muaj mob ntshav qab zib retinopathy. Kev nce ntxiv sai sai ntawm kev siv tshuaj insulin tom qab kev ua tiav tsis tiav ntawm kev txhim kho ntawm glycemia nce qhov kev pheej hmoo ntawm kev mob ntshav qab zib retinopathy. Hauv cov neeg mob uas muaj kev loj dua retinopathy, tshwj xeeb tshaj yog cov uas tsis tau yauv mus ua photocoagulation, mob ntshav qab zib tsawg tuaj yeem ua rau amaurosis.
Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: feem ntau - lipohypertrophy, tsis tshua muaj - lipoatrophy, uas ua rau cov qeeb hauv kev nqus hauv zos ntawm insulin. Kev hloov pauv tsis tu ncua ntawm thaj chaw txhaj tshuaj tuaj yeem txo qhov hnyav ntawm cov tshwm sim no lossis tiv thaiv lawv. Tej zaum qhov kev txhim kho ntawm thaj chaw hyperemia ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj (hauv 3-4% ntawm cov neeg mob), uas ploj mus thaum kho ntxiv rau ob peb hnub mus rau ntau lub lis piam.
Los ntawm cov leeg musculoskeletal: tsis tshua muaj heev - myalgia.
Cov tshuaj tiv thaiv dav dav thiab hauv zos: feem ntau - cov tshuaj tiv thaiv nyob ntawm thaj chaw txhaj tshuaj (hyperemia, mob, khaus, khaus, o lossis o). Cov kev tawm tsam hauv zos feem ntau, raws li txoj cai, dhau rau ob peb hnub lossis ntau lub lim tiam.
Qee qhov xwm txheej, kev tswj hwm ntawm insulin npaj ua rau kev ncua sijhawm sodium thiab dej hauv lub cev thiab qhov pom ntawm peripheral edema, yog tias kev tswj glycemic dhau los tsis txaus.

Cov lus qhia tshwj xeeb rau kev siv cov tshuaj Lantus

Lantus tsis yog cov tshuaj insulin ntawm kev xaiv hauv kev kho mob ntshav qab zib ketoacidosis. Hauv cov xwm txheej zoo li no, iv kev tswj hwm ntawm cov tshuaj insulin yooj yim raug pom zoo.
Ua ntej pib kev hloov kho cov tshuaj tiv thaiv ntawm qhov tsis txaus ntseeg tswj tau ntshav ntshav lossis tus cwj pwm ntawm cov ntshav lossis ntshav qab zib, nws yog qhov yuav tsum tau kuaj xyuas tus neeg mob kom ua raws li cov kev xav kho, qhov chaw txhaj tshuaj, cov txheej txheem tseeb ntawm kev tswj hwm tshuaj thiab lwm yam tseem ceeb.
Kev ntshav siab. Vim yog lub pharmacokinetics ntawm Lantus (ib qho kev yug ntxiv ntawm cov tshuaj insulin ib puag ncig), qhov kev txhim kho ntawm lub qog ntshav qab zib yuav ntau dua thaum sawv ntxov ntxov dua li thaum hmo ntuj.
Nrog kev ceev faj heev thiab nrog kev saib xyuas tas li ntawm glycemia, cov tshuaj no yog siv rau hauv cov neeg mob uas tus neeg mob ntshav qab zib yog qhov hnyav tshwj xeeb, piv txwv li hauv cov neeg mob uas mob hnyav ntawm cov hlab ntshav ntawm lub plawv lossis cov hlab ntsha hauv hlab ntsha (kev pheej hmoo ntawm mob plawv lossis mob hlwb ntau ntawm hypoglycemia), zoo ib yam li cov neeg mob muaj mob loj heev. retinopathy, uas tsis tau yauv mus ua photocoagulation (kev pheej hmoo ntawm amaurosis dhau los).
Ua raws li kev tswj hwm ntawm kev siv tshuaj thiab khoom noj khoom haus, kev tswj hwm insulin kom raug thiab kev paub txog cov tsos mob ntawm tus mob ntshav qab zib yog ib qho tseem ceeb kom txo qis kev mob ntshav siab ntshav qis.
Cov teeb meem pheej hmoo rau kev txhim kho hypoglycemia suav nrog: hloov qhov chaw txhaj tshuaj, nce insulin rhiab heev (piv txwv, tom qab tshem tawm kev ntxhov siab), kev tawm dag zog lossis lub sijhawm ntev, kev ua haujlwm ntawm lub cev tsis muaj zog, ntuav, raws plab, hla zaub mov noj, haus dej cawv, qee cov kab mob endocrine tsis meej (hypothyroidism, tsis txaus ntseeg) kev tso tshuaj rau lub qog nqaij hlav hauv lub raum lossis adrenal ua haujlwm), siv ua ke nrog qee yam tshuaj.
Hauv qee qhov xwm txheej, cov tsos mob ua ntej ntawm kev txo qis ntshav qab zib tuaj yeem hloov, poob lawv qhov mob hnyav lossis txawm tias tsis tuaj yeem: muaj keeb kwm ntev los ntawm ntshav qab zib mellitus, mob hlwb, autonomic neuropathy, kev siv ua ke ntawm qee lwm yam tshuaj, kev hloov pauv ntawm insulin ntawm tsiaj keeb kwm rau tib neeg, nrog rau cov neeg laus laus lossis maj mam kev loj hlob ntawm hypoglycemia lossis nrog qhov cim txhim kho hauv kev tswj glycemic. Hauv qhov xwm txheej no, mob ntshav qab zib siab ntau tej zaum yuav muaj tshwm sim (nrog tsis paub qab hau) txawm tias ua ntej tus neeg mob paub qhov tseeb ntawm hypoglycemia.
Nrog tus kom qis los yog qis dua ntawm glycosylated hemoglobin, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej qhov ua tau ntawm rov ua dua, latent (tshwj xeeb tshaj yog thaum tsaus ntuj) ntu kev mob ntshav qab zib tsawg.
Mob kab mob Cov. Nyob rau hauv muaj ib tug kab mob concomitant, kev saib xyuas nruj ntawm cov metabolism ntawm tus neeg mob yog qhov tsim nyog. Feem ntau, kev txiav txim siab ntawm ketones nyob rau hauv cov zis yog qhia, nws yog feem ntau yuav tsum kho cov koob tshuaj insulin. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob uas muaj ntshav qab zib hom I yuav tsum nquag haus zaub mov, txawm tias yog me me xwb, los sis ua kom ntuav, thiab lwm yam. Tsis txhob tso cov tshuaj insulin txhua hnub.
Lub siab mob raum lossis lub raum ua haujlwm. Vim tsis muaj kev paub dhau los, qhov ua tau zoo thiab kev nyab xeeb ntawm Lantus rau cov neeg mob uas lub siab tsis ua haujlwm lossis muaj qhov tsis xwm yeem thiab / lossis mob raum tsis muaj peev xwm piav tau meej. Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin yuav txo qis vim muaj cov tshuaj insulin metabolism ua kom tsawg. Hauv cov neeg laus neeg mob, lub raum qis qis dua tuaj yeem ua rau txo qis hauv cov tshuaj insulin.
Hauv cov neeg mob uas muaj mob hepatic loj, qhov xav tau ntawm cov tshuaj insulin tuaj yeem txo vim yog txo qis qis hauv gluconeogenesis thiab qeeb hauv insulin metabolism.
Cev xeeb tub thiab lactation Cov. Tsis muaj kev sim kho mob raws li kev tshawb fawb hauv kev kho mob txog kev siv tshuaj insulin glargine thaum cev xeeb tub. Hauv kev tshawb nrhiav pom, tsis muaj qhov cuam tshuam txog teratogenic thiab embryotoxic rau lub sijhawm cev xeeb tub, nrog rau kev yug menyuam thiab kev loj hlob hauv lub sijhawm yug menyuam.
Yog li, kev saib xyuas yuav tsum tau coj thaum lub tshuaj ntawm cov tshuaj. Thaum cev xeeb tub, suav nrog rau cov neeg mob ntshav qab zib mob tsis txaus, nws yog ib qho tseem ceeb uas tswj hwm theem ntawm glycemia. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb hlis thaum cev xeeb tub thiab nce hauv lub hlis thib ob thiab peb lub hlis. Tam sim ntawd tom qab yug los, xav tau cov tshuaj insulin sai sai (qhov kev pheej hmoo ntawm kev muaj ntshav qab zib nce ntxiv), yog li nws yog ib qho tseem ceeb kom ua tib zoo saib xyuas qib ntshav qab zib hauv cov ntshav ntshav. Thaum pub niam mis, yuav tsum muaj kev hloov kho cov tshuaj insulin thiab kev noj zaub mov noj.
Cov menyuam. Qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv Lantus hauv menyuam yaus tau ua pov thawj tsuas yog siv rau yav tsaus ntuj. Lantus tsis siv rau hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo, vim tias qhov kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj hauv cov menyuam yaus uas muaj hnub nyoog txaus qhia tsis tau muaj pov thawj.
Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb thiab ua haujlwm nrog tshuab. Cov xwm txheej tsis zoo xaiv cov koob tshuaj lossis hloov chaw hloov tshuaj, nrog rau qhov xwm txheej tsis zoo lossis kev noj zaub mov tsis xwm yeem, kev hloov pauv ntau dhau ntawm cov piam thaj hauv ntshav plasma muaj peev xwm, feem ntau mus rau hypoglycemia, uas tuaj yeem cuam tshuam rau lub peev xwm tsav tsheb, tshwj xeeb tshaj yog thaum pib lub sijhawm kho, nrog rau kev sib xyaw ua ke ntawm kev haus cawv lossis tshuaj yeeb tshuaj rau hauv nruab nrab lub paj hlwb.

Tshuaj sib cuam tshuam Lantus

Kev mob ntshav qab zib tsawg tuaj yeem tsim kho nrog kev siv tshuaj Lantus nrog rau lub qhov ncauj hypoglycemic, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline,propoxyphene, salicylates thiab sulfonamides. Qhov ua tau zoo ntawm Lantus tuaj yeem txo los ntawm corticosteroids, danazol, diazoxide, glucagon, isoniazid, estrogens thiab progesterone, phenothiazine derivatives, somatropin, sympathomimetics (epinephrine, salbutamol, terbutaline), cov thyroid hormones, atypical antipsychotic tshuaj, clinzapininsin tshuaj tiv thaiv. Ers-adrenoreceptor blockers, clonidine, lithium ntsev, pentamidine lossis dej cawv tuaj yeem ua rau muaj zog lossis ua kom cov ntshav tsis muaj zog ntawm insulin. Nrog tib lub sijhawm siv β-adrenergic receptor blockers, clonidine, guanethidine, reserpine nrog cov tshuaj insulin, lawv cov teebmeem tuaj yeem txo qis lossis ploj, nrog rau qhov ua rau tsis muaj zog ntawm adrenergic counterregulation.
Lantus yuav tsum tsis txhob muab sib xyaw nrog lwm cov tshuaj. Cov koob txhaj tshuaj rau txoj kev qhia ntawm Lantus yuav tsum tsis muaj cov kab ntawm lwm cov tshuaj.

Kev noj tshuaj ntau dhau ntawm Lantus, cov tsos mob thiab kev kho mob

Tej zaum yuav ua rau lub raum tsis txaus thiab ua kom ntshav ntev. Cov ntshav qab zib me me tuaj yeem raug tshem tawm los ntawm kev noj zaub mov hauv qhov ncauj. Hauv cov ntshav qog ntshav qab zib heev (mob ntshav tes taw hauv lub paj hlwb, tsis nco qab lawm), tso tshuaj ntshav ntshav ntshav lossis ntshav tshuaj ntshav qab zib, tswj ntshav qabzib yog yuav tsum muaj. Tom qab siv ceev xwmphem hypoglycemia, kev soj ntsuam cov neeg mob thiab kev noj haus carbohydrate yuav tsum tau, txij li thaum lub sijhawm hypoglycemic yuav rov tshwm sim qee lub sijhawm.

Cia tej yam kev mob ntawm cov tshuaj Lantus

Ntawm qhov kub ntawm 2-8 ° C. Tsis txhob pub kom khov. Tsis txhob muab lub thauv tso rau hauv lub taub yees txias. Thaum siv, khaws cia rau qhov chaw sov li 25 ° C. Lub raj mis qhib yuav tsum siv rau 28 hnub thaum muab cia rau qhov chaw txias thiab tsaus ntawm qhov kub txog li 25 ° C (tab sis tsis nyob hauv tub yees).

Sau cov chaw muag tsuaj uas koj tuaj yeem yuav Lantus:

Dosage daim ntawv

1 ml ntawm kev daws

cov tshuaj nquag - insulin glargine (equimolar units ntawm insulin) 3.6378 mg (100 units)

kev zam rau kev daws nyob rau hauv daim cartridge: metacresol, zinc chloride, glycerin (85%), sodium hydroxide, concentrated hydrochloric acid, dej rau kev txhaj tshuaj.

kev tshem tawm rau cov tshuaj hauv vial: metacresol, polysorbate 20, zinc chloride, glycerin (85%), sodium hydroxide, concentrated hydrochloric acid, dej rau kev txhaj tshuaj.

Transparent tsis muaj kob lossis yuav luag tsis muaj cov kua.

Cov chaw muag tshuaj

Piv rau tib neeg NPH-insulin, ntshav dej insulin ntau hauv cov ntsiab lus noj qab haus huv thiab cov neeg mob ntshav qab zib tom qab kev saib xyuas ntawm insulin glargine qhia tau qeeb dua thiab ua rau lub siab ntev dua, nrog rau qhov tsis muaj lub siab tshaj. Yog li, qhov ntau ntau tau raws li cov ntsiab lus ntawm lub cev ntu ntawm kev ua haujlwm pharmacodynamic ntawm insulin glargine. Daim duab 1 qhia txog cov haujlwm kev ua ntawm insulin glargine thiab NPH-insulin tiv thaiv lub sijhawm. Nrog cov lus qhia ntawm ib zaug ib hnub, qhov sib luag ntawm cov tshuaj insulin glargine nyob rau hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug. Nrog kev tswj hwm intravenous, ib nrab-lub neej ntawm insulin glargine thiab insulin tib neeg tau sib piv.

Tom qab subcutaneous txhaj ntawm Lantus hauv cov neeg mob ntshav qab zib mellitus, insulin glargine yog sai metabolized thaum kawg ntawm polypeptide beta saw los ua ob lub cev siv tshuaj tiv thaiv M1 (21A-Gly-insulin) thiab M2 (21A-Gly-des-30B-Thr insulin). Hauv ntshav, cov kab mob loj ntawm lub voj voog yog cov tshuaj metabolite M1. Qhov kev tshwj xeeb ntawm cov metabolite M1 nce ntxiv raws li qhov tau hais tseg ntawm Lantus.

Pharmacokinetic thiab pharmacodynamic cov txiaj ntsig tau qhia tias cov nyhuv ntawm subcutaneous txhaj ntawm Lantus feem ntau yog ua raws li kev rho tawm ntawm M1 metabolite. Insulin glargine thiab metabolite M2 tsis pom nyob rau hauv cov neeg mob feem ntau, thaum lawv nrhiav tau, lawv qhov kev tsom xam yog ywj siab ntawm cov tshuaj Lantus.

Hauv kev sim kho mob, kev soj ntsuam ntawm pawg neeg tau tsim los ntawm lub hnub nyoog thiab poj niam txiv neej tsis qhia txog qhov txawv ntawm qhov ua tau zoo thiab kev nyab xeeb ntawm cov neeg mob kho nrog insulin glargine thiab tag nrho cov pej xeem tau kawm.

Pharmacokinetics rau cov menyuam yaus hnub nyoog 2 txog 6 xyoo uas muaj ntshav qab zib hom 1 tau raug soj ntsuam hauv ib qhov kev tshawb fawb soj ntsuam (saib "Pharmacodynamics"). Qhov "tsawg kawg" theem ntawm insulin glargine thiab nws lub ntsiab ntshav plasma metabolites M1 thiab M2 tau ntsuas rau cov menyuam yaus raug kho nrog insulin glargine, thiab nws tau pom tias cov ntshav plasma piv txwv zoo ib yam li cov laus kuaj, cov pov thawj txhawb kev tsub zuj zuj ntawm insulin glargine lossis nws cov metabolites. nrog rau kev tswj hwm ncua ntev yog tsis tuaj.

Insulin glargine yog ib qho piv txwv ntawm tib neeg cov kua dej, tsim kom muaj cov solubility qis ntawm pH nruab nrab. Nws yog kiag li soluble ntawm acidic pH ntawm Lantus® Txhaj Tshuaj (pH 4). Tom qab kev tswj hwm subcutaneous, cov tshuaj acidic yog nruab nrab, ua rau muaj kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine txuas ntxiv tso tawm me me, muab ib qho tseem ceeb, tsis pub dawb, kom paub tseeb txog lub sijhawm / sijhawm nrog kev ua haujlwm ntev.

Kev khi rau cov tshuaj insulin: hauv kev tshawb fawb hauv vitro qhia tau tias qhov sib thooj ntawm insulin glargine thiab nws cov metabolites M1 thiab M2 rau tib neeg cov tshuaj insulin yog tib yam rau tib neeg cov insulin.

IGF-1 receptor khi: qhov sib thooj ntawm insulin glargine rau tib neeg IGF-1 receptor yog kwv yees li 5-8 npaug ntau dua li ntawm tib neeg ntawm insulin (tab sis kwv yees li 70-80 npaug qis dua IGF-1), thaum M1 metabolites. thiab M2 khi rau IGF-1 receptor nrog kev sib txuam me ntsis piv rau tib neeg cov insulin.

Tag nrho cov tshuaj tua kab mob ntawm cov tshuaj insulin (insulin glargine thiab nws cov metabolites), txiav txim siab hauv cov neeg mob ntshav qab zib hom ntshav qab zib, tsawg tshaj li qhov yuav tsum tau ua rau ib nrab cov lus teb tshaj plaws los ntawm kev ntes ntawm IGF-1 receptor thiab tom qab ua kom muaj cov kab mob rau txoj kev ua kom cov kab mob ua rau muaj IGF-1 receptor. Cov. Kev tawm dag zog lub zog ntawm endogenous IGF-1 tuaj yeem ua kom cov kab mob ntawm txoj kev loj hlob ntawm txoj kev loj hlob, txawm li cas los xij, kev kho mob ntau yam tau txiav txim siab thaum lub sij hawm kho mob insulin, suav nrog kev kho Lantus, nws qis dua qhov kev siv tshuaj pharmacological xav tau kom ua IGF-1 txoj kev.

Kev ua haujlwm thawj zaug ntawm insulin, suav nrog insulin glargine, yog tswj kev metabolism hauv qabzib. Cov tshuaj insulin thiab nws cov kab mob sib txig txo cov ntshav qabzib ntau ntau ntxiv los ntawm kev nce ntxiv cov piam thaj hauv cov ntaub so ntswg, tshwj xeeb tshaj yog cov leeg pob txha thiab adipose cov nqaij, zoo li los ntawm kev tsim cov piam thaj hauv siab. Cov tshuaj Insulin muab cov lipolysis hauv adipocytes, inhibits proteolysis thiab txhim kho cov protein synthesis. Cov kev tshawb fawb soj ntsuam thiab pharmacological tau qhia tias kev muab cov tshuaj insulin glargine thiab tib neeg cov tshuaj insulin yog qhov sib npaug thaum muab rau tib zaug. Ib yam li txhua yam insulins, kev tawm dag zog thiab lwm yam tuaj yeem cuam tshuam lub sijhawm ntawm kev ua ntawm insulin glargine.

Hauv cov kev tshawb fawb siv euglycemic clamp hauv kev noj qab haus huv tuaj pab dawb thiab cov neeg mob uas muaj hom 1 ntshav qab zib mellitus, qhov kev txiav txim ntawm subcutaneously txhaj tshuaj insulin glargine tau qeeb qeeb dua tib neeg NPH insulin, cov nyhuv ntawm insulin glargine tau zoo thiab tsis tiav, nws lub sijhawm ntev dua.

Sijhawm (xuab moos) elapsed tom qab txhaj subcutaneous

Xaus kev soj ntsuam lub sijhawm

* tau txhais tias yog cov piam thaj qhia txog ntshav qab zib kom ntshav txhawm rau ib qib (ib teev ntawm ib nrab).

Cov kev ua ntev ntev ntawm subcutaneous insulin glargine cuam tshuam ncaj qha rau nws txoj kev nqus qeeb, uas tso cai rau cov tshuaj siv ib hnub ib zaug.Hauv cov tib neeg sib txawv thiab hauv tib tus neeg, lub sijhawm ntawm kev ua ntawm insulin thiab nws cov analogues, xws li insulin glargine, tuaj yeem sib txawv.

Hauv qhov kev tshawb fawb soj ntsuam, cov tsos mob ntawm lub qog ntshav qab zib lossis cov cim ntawm kev tiv thaiv kev tiv thaiv hormonal hauv cov neeg ua haujlwm pab dawb noj qab haus huv thiab nyob rau cov neeg mob ntshav qab zib hom 1 tau zoo ib yam tom qab kev tso ntshav tshuaj insulin glargine thiab tib neeg insulin.

Cov tshuaj insulin lantus thiab nws cov khoom sib txig sib luag. Cov tshuaj Insulin Lantus thiab nws cov lus sib txig: peb suav cov koob tshuaj thaum sawv ntxov thiab yav tsaus ntuj kom raug

Mob ntshav qab zib hom mob Insulin-tiv thaiv kab mob ntshav qab zib (T1DM) yog ib qho kab mob muaj keeb, feem ntau ua rau poob thaum hluas. Hauv hom mob ntshav qab zib no, pancreatic beta hlwb tsis tsim txaus los yog tsis tsim cov tshuaj insulin hormone (Insulinum), uas yog lub luag haujlwm rau kev siv cov piam thaj hauv cov ntshav los ntawm cov leeg pob txha pob txha.

Txhawm rau pab lub cev nqus cov ntshav qabzib thiab tsis tuag los ntawm cov piam thaj intoxication, cov neeg mob tau quab yuam kom nqus cov tshuaj insulin uas zoo ib yam li tib neeg, suav nrog cov tshuaj Insulin Lantus thiab nws cov tshuaj noj.

Cov ntaub ntawv thiab cov yeeb yaj kiab hauv tsab xov xwm no yuav mob siab rau lub ncauj lus no. Los ntawm txoj kev, nws tuaj yeem siv tau tsis zoo rau cov mob ntshav qab zib insulin-mob ntshav qab zib nrog T1DM, tab sis kuj siv rau cov neeg mob uas tsis muaj tshuaj insulin, thiab ntxiv rau cov poj niam cev xeeb tub uas muaj ntshav qab zib mob gestational.

Kev txhaj tshuaj nyob ib ntus “insulin ntev” tuaj yeem sau tseg los ntawm nws, piv txwv, txhawm rau them nyiaj rau qhov mob hnyav ntawm cov mob, thaum lub sijhawm mob SARS lossis lwm tus kabmob sib kis. Lawv yuav pab tiv thaiv kev tsim lossis txheej txheem ntawm cov ntshav qab zib muaj teeb meem hauv cov hlab plawv, ob lub raum thiab qhov muag.

Txog kev hloov kho cov tshuaj ntshav qab zib rau cov ntshav qab zib, 5 hom insulin hormone npaj tau tsim thiab tab tom ua:

bolus () - siv tau ua ntej noj mov, los yog qhia kom sai kho lub siab ntawm cov piam thaj hauv cov ntshav,
NPH (NPH) thiab basal (nruab nrab thiab ntev ua) - tsim nyog los tswj ntshav qab zib ntawm ntu thaum bolus insulins twb nres lawv txoj haujlwm,
paus bolus (kev sib txuas ntawm bolus cov ntaub ntawv nrog NPH lossis basal, nrog rau kev sib xyaw ntawm NPH thiab basal) yog qhov yooj yim heev, tab sis lawv siv ntau yam ua rau muaj kev kub ntxhov loj thiab qhov xav tau ntawm kev tawm tsam ntawm kev tawm tsam los ntawm qhov no.

Lantus yog ib qho kev ua yeeb yam ntev ntev ntawm kev tsim cov tshuaj insulin. Qhov tseeb, Lantus yog lub npe lag luam ntawm thawj cov yeeb yaj kiab ntawm tib neeg Insulinum nrog 24-teev qhov kev ua tsis tiav, uas tau tsim los ntawm lub tuam txhab tshuaj thoob ntiaj teb Sanofi-Aventis, nrog lub hauv paus hauv Paris.

Cov tshuaj nquag Lantus yog hloov kho tib neeg cov insulin glargine. Lantus muaj nyob hauv 1 ml 100 IU (3.6378 mg) ib yam khoom zoo ib yam li tib neeg lub cev, qhov uas asparagine los ntawm amino acid a-saw yog hloov los ntawm glycine molecule, thiab 2 arginine residues yog "glued" mus rau qhov kawg ntawm b-saw.

Ua tsaug rau cov qauv no, qhov kev tsim hluav taws xob tsim muaj cov yam ntxwv hauv qab no:

cov tshuaj feem ntau yog ua raws li lub ntsej muag ntuj tsim ntawm Insulinum hauv tib neeg lub cev,
qhov kev txhaj tshuaj tsuas yog ua tiav 1-2 zaug nyob rau ib hnub, thiab tsis tas yuav cuam tshuam kev pw tsaug zog los ua ib qho kev txhaj tshuaj ntxiv, qhia tswj cov ntshav qabzib thaum hmo ntuj,
tsis txhob sib tov cov tshuaj ua ntej txhaj tshuaj,
glycemia tau txais txiaj ntsig zoo los ntawm kev them nqi tsis tu ncua rau ntshav qab zib,
txoj kev pheej hmoo ntawm hypoglycemia yog tsawg heev,
Tsis zoo li lwm yam tshuaj, tsis muaj qhov sib txawv rau qhov twg prick - hauv qab daim tawv nqaij ntawm lub plab, ncej puab lossis xub pwg,
qhov kev txiav txim yog tus, nco txog ntawm tus nqi kim kawg profile ntawm kev nruam subcutaneous infusion ntawm insulin hormone,
txhim kho zuag qhia tag nrho cov carbohydrate-lipid metabolism.

Saib xyuasCov neeg mob ntshav qab zib nrog ib txwm los yog txo qis ntawm glycated hemoglobin yuav muaj qee zaum muaj kev tsis pom kev zoo thaum hmo ntuj cov ntshav qog ntshav qab zib.

Insulin Lantus cov lus qhia rau kev siv kom meej meej qhia tias cov neeg mob ntshav qab zib yuav tsum nco ntsoov - theem ntawm kev qoj ib ce cuam tshuam qhov xwm ntawm kev ua ntawm glargine. Yog li, ua ntej thiab tom qab kev cob qhia (kev tawm dag zog tawm dag zog lossis lwm yam kev tawm dag zog ntawm lub cev, piv txwv li, ua haujlwm hauv vaj), kev ntsuas ntshav qabzib yog qhov tsim nyog, thiab yog tias tsim nyog, kho nrog ultra-luv insulin.

Rau ib daim ntawv. Zoo ib yam li lwm yam tshuaj uas muaj cov tshuaj hormonal, Lantus insulin glargine lossis nws cov analogues yuav tsum tau muab cia rau hauv qis qis ntawm lub tub yees, ntawm huab cua kub ntawm 2 txog 8 degrees Celsius. Tom qab qhib cov tshuaj, nws lub txee lub neej yog li 40 hnub.

Analogs Lantus

Cov lus sau rau Lantus yog lub txim hluav taws xob Tujeo SoloStar koob txhaj tshuaj. Dab tsi yog qhov txawv ntawm lawv? Cov tshuaj nquag ntawm Tujeo yog tib yam li ntawm Lantus - glargine, tab sis hauv 1 ml ntawm Tujeo cov tshuaj nws muaj 3 zaug ntau dua li hauv Lantus.

Qhov no tso cai rau koj txuas ntxiv qhov kev txiav txim los ntawm 24 teev mus rau 35, thiab kuj tseem txo qis kev pheej hmoo ntawm kev tsim hypoglycemic tawm tsam. Hmoov tsis zoo, muaj ntau qhov kev tshawb xyuas tsis zoo los ntawm Tujeo hauv Is Taws Nem, tab sis feem ntau lawv yuav yog ib qho kev suav tsis raug los ntawm cov neeg mob ntshav qab zib ntawm cov sij hawm hloov pauv los ntawm ib cov tshuaj ntev mus rau lwm qhov.

Tam sim no, cov qauv ntawm Lantus SoloStar (insulin glargine) yog:

Levemir thiab Levemir Flexpen los ntawm Novo Nordisk. Lawv lub hauv paus yog cov tshuaj tua kab mob insulin kom paub tseeb. Tsis zoo li lwm txoj kev npaj tshuaj insulin ntev, nws tuaj yeem hloov kho, ua rau nws yog qhov zoo tshaj plaws rau tshuaj rau me nyuam yaus muaj ntshav qab zib. Koj tuaj yeem kawm paub ntau ntxiv txog cov txiaj ntsig ntawm cov tshuaj hormonal no los ntawm kev yees duab.

Tresiba, Tresiba FlekTach thiab Tresiba Penfill raws li cov tshuaj nquag nquag insulin degludec. Tso cai siv rau cov menyuam yaus hnub nyoog 12 lub hlis. Nws muaj lub sijhawm ntev tshaj ntawm kev ua ntawm 42 teev. Kev siv hom insulin no pab tswj hwm ntawm qhov tshwm sim tsis zoo rau cov neeg mob ntshav qab zib "thaum sawv ntxov mob syndrome".

Rau cov neeg uas muaj peev nyiaj txiag, txawv teb chaws endocrinologist pom zoo hloov ntawm Lantus ntev mus rau lub caij ntev Levemir lossis, tshwj xeeb, ntev tshaj plaws ntawm txhua tus uas twb muaj lawm, Tresiba insulin. Kawg tshuaj insulin analogue Lantus - degludec, yog suav tias yog qhov zoo tshaj plaws ntawm kev puas tsuaj Insulinum. Txawm li cas los xij, qhov zoo tshaj plaws, alas, tib lub sijhawm tseem kim tshaj plaws.

Dab tsi yog Lantus SoloStar?

Lantus SoloStar tsis siv rau glargin analogues. Qhov tsuas yog qhov txawv ntawm "Lantus zoo tib yam" thiab SoloStar yog daim ntawv "ntim" ntawm cov tshuaj nquag glargine. Tiag tiag, SoloStar yog lub npe siv rau tus cwj mem kua tshwj xeeb thiab ib-lub koob rab koob rau nws.

Cov yam ntxwv ntawm kev siv cov insulin ntev thaum cev xeeb tub

Cov poj niam cev xeeb tub uas yuav tsum tau txhaj tshuaj rau cov tshuaj insulin yuav tsum nco ntsoov, txawm hais tias cov tshuaj no tsis muaj peev xwm hla tus txiv neej, nws tseem ceeb tias cov tshuaj ntawm cov menyuam hauv plab tau kawm los ntawm kev tshawb fawb kev kho mob, thiab nws txoj kev nyab xeeb raug pom tseeb los ntawm kev sim tswj xyuas.

Niaj hnub no, cov lus pom hauv qab no thiab cov lus pom zoo muaj nyob rau:

Kev sim hnyav ntawm Tujeo thiab Tresib nrog kev koom tes ntawm cov poj niam cev xeeb tub tseem tsis tau ua, yog li nws tsis pom zoo kom siv lawv.
Kev nyab xeeb rau Lantus tus me nyuam hauv plab tsis tau muaj pov thawj tag nrho, tab sis qhov kev paub zoo tau dhau los thoob plaws ntiaj teb, nrog cov txiaj ntsig zoo tsis muaj qhov tsis zoo rau kev noj qab haus huv ntawm cov menyuam yaus, tau muab rau, xyoo 2017, tau tso cai rau kev siv nws hauv tebchaws Russia.
Feem ntau kawm los ntawm cov kws kho mob Levemir.Nws raug nquahu tias nws siv ob qho tib si thaum cev xeeb tub thiab rau cov poj niam muaj ntshav qab zib kom pauv mus rau nws twb tau nyob rau theem ntawm kev npaj lub tswv yim.

Rau ib daim ntawv. Daim ntawv teev cov luv luv insulin cov tshuaj hormones, nrog cov pov thawj kev nyab xeeb rau kev loj hlob ntawm tus me nyuam hauv plab, suav nrog Humalog thiab Novorapid, thiab Apidra poob rau hauv qeb txwv.

Yuav siv cov tshuaj insulin basal li cas li cas?

Ua ntej suav cov koob tshuaj rau kev kho tshuaj insulin nrog ib qho ntawm ntev ntawm cov kab mob insulin, koj yuav tsum ua ntej:

Twv yuav raug thiab txwv tsis pub mus ntawm kev noj haus kom tsawg carb. Yog tias tsis muaj kev ua raws nruj, nws tsuas yog ua tsis yooj yim kom ua tiav ntawm kev txiav tawm cov ntshav qabzib nyob rau theem ntawm 3.9-5.5 mmol / L, thiab yog li ntawd txhawm rau tiv thaiv kev txhim kho ntawm cov ntshav qab zib muaj teeb meem.

Pib sau cov ncauj lus kom ntxaws qhov twg los sau:
1. cov ntshav qab zib cov cim, tsawg kawg nkaus - thaum sawv ntxov ntawm lub plab khoob, tom qab 3 teev tom qab noj tshais, ua ntej noj su thiab 3 teev tom qab nws, nrog rau ua ntej noj hmo thiab ua ntej mus pw,
2. noj cov zaub mov, tais diav, haus,
3. noj tshuaj ntxiv
4. dab tsi thiab thaum twg cov insulin hormone txhaj tshuaj, qhov tshuaj tiv thaiv yog dab tsi, qhov chaw hauv zos txhaj tshuaj thiab seb nws ntws tawm
5. dab tsi thiab cov kev ua haujlwm hauv lub cev ua li cas cuam tshuam rau theem ntawm cov piam thaj hauv ntshav (kev ntsuas lub suab thaj yog tsim nyog ua ntej thiab tom qab),
6. lub cev teb - kom zoo thiab qab zib theem: tom qab kev ntxhov siab, huab cua, tom qab noj cawv thiab kas fes.
Ua kom koj tus kheej noj hmo kom ntxov - noj txhob pub dhau 5 teev ua ntej mus pw.
Xaiv lub sijhawm tshwj xeeb, nyiam dua 1 teev ua ntej mus pw, rau qhov hnyav txhua hnub. Tsis txhob ua tub nkeeg los sau cov duab no hauv phau ntawv sau cia.

Sim sau cov ncauj lus kom ntxaws thiab cov ncauj lus kom ntxaws. Nqus nyiaj tsis tau, thiab nyob rau hauv 4-7 hnub, ntsuas koj cov piam thaj kom ntau li ntau tau.

Tswv yim. Cov tshuaj insulin ntev ntev tuaj yeem raug txhaj ua ntej yuav mus pw lossis sawv ntxov. Kev txhaj tshuaj rau yav tsaus ntuj pab tshem tawm qhov mob thaum sawv ntxov ntxov los ntawm kev tswj ntshav qab zib thaum hmo ntuj thiab sawv ntxov. Yog tias nws tau sau tseg tias kev noj mov ntxov ua rau koj tso cov ntshav qabzib nyob rau thaj tsam ntawm 4.0-5,5 mmol / l, tom qab ntawd koj tsis tas yuav txhaj cov tshuaj insalin ua ntej yuav mus pw.

Cov lus qhia rau xam qhov ntau npaum li cas ntawm insulin ntev thaum hmo ntuj

Txhawm rau pib nrog, siv cov ntawv sau cia, los ntawm kev xam, txiav txim siab qhov sib txawv me tshaj plaws, rau 3-4 hnub dhau los, nyob rau hauv cov ntshav qabzib qhov txiaj ntsig tau ntsuas thaum yav tsaus ntuj thiab ntawm lub plab khoob thaum sawv ntxov (MRHU). Tom qab ntawd ua rau cov kev suav raws li cov qauv tshuaj pom zoo los ntawm American endocrinologist Richard Bernstein.

Muab cov leb txav mus rau 0.5. Tsis txhob txhawj xeeb yog tias cov tshuaj tau txais pib yog tsawg - 1 lossis 0.5 units. Tuav nws, thiab tsis txhob hnov qab tswj lub suab thaj nrog glucometer thaum sawv ntxov. Yog tias tom qab 3 hnub ntawm txoj kev kho no koj tsis ua tiav qhov xav tau ntawm 4.0-5.5 mmol / l, tom qab ntawd nce qib pib los ntawm 0.5 units, thiab tho rau lwm 3 teev tsaus ntuj. Tsis tau ua haujlwm dua ntxiv lawm? Tsa lwm 0.5 qhov.

Nws yog qhov tseem ceeb. Firstly, cov txiaj ntsig zoo ntawm qabzib tsis cuam tshuam txog qhov "tsaus ntuj" koob tshuaj insulin basal. Thib ob, tsis txhob maj nrawm rau xaiv cov koob tshuaj zoo tshaj plaws rau hmo ntuj; nco ntsoov tswj qhov "theem" ntawm 3 hnub.

Yuav muaj dab tsi yog tias koj tsis mus txhaj tshuaj?

Koj yuav muaj ntshav siab cov ntshav qab zib vim qhov tsis muaj cov insulin hauv lub cev. Ntau dua, qhov tsis meej yog vim muaj qhov tsis sib xws ntawm cov theem ntawm cov kua dej nrog cov kev xav tau ntawm lub cev. Muaj cov piam thaj ntau ntau yuav ua rau kev txhim kho.

Thaum muaj mob hnyav, cov mob hnyav kuj tuaj yeem pom: tus mob ntshav qab zib ketoacidosis lossis hyperglycemic coma. Lawv cov tsos mob yog tsis nco qab. Lawv tuaj yeem ua neeg tuag taus.

Cov qauv rau xam lub koob tshuaj ntawm basal insulin thaum sawv ntxov

Kev qhia ntawm Dr. R. Bernstein muaj raws li nram no:

Tsaus tshaib ib hnub rau ntawm cov tshuaj yej thiab dej, sau cia cov ntsuas hauv cov teev hauv lub rooj.

Los ntawm cov piam thaj qis tshaj tus nqi, qhov no - 5.9, rho tus lej 5, uas yog lub hom phiaj nruab nrab ntawm cov ntshav qab zib ib txwm nyob.Yog li, RSNNS (qhov sib txawv ntawm qib qis thiab qab zib li qub).
Tom ntej no, nqa tawm cov kev xam raws li tus qauv, nco ntsoov tias qhov hnyav yuav tsum tau sau nyob rau hauv kg, tab sis nrog qhov tseeb ntawm ib tus lej tom qab lub kaum sib.

Txhawm rau paub meej tias kev ua lag luam lossis kho qhov tshuaj, ua raws cov txheej txheem no:
1. nkag rau thaum sawv ntxov
2. hla pluas tshais, su thiab khoom noj txom ncauj (koj tuaj yeem haus dej thiab tsis muaj dej tshuaj yej),
3. thaum nruab hnub, ua ntej noj hmo ua ntej, ua 4-5 ntsuas nrog lub ntsej muag glucometer, thiab raws li cov kev ntsuas no txiav txim siab txiav txim siab seb puas yuav hloov cov koob tshuaj thiab yog tias muaj, hauv cov kev taw qhia, txo lossis nce, qhov no yuav tsum tau ua.

Saib xyuas! Tom qab txhaj tshuaj ntawm ib qho ntawm cov insulins txuas ntxiv, koj tsis tas yuav noj zaub mov.

Thiab hauv kev xaus, peb xav muab qee cov lus qhia los ntawm kev xyaum ua tus kws kho mob endocrinologist:

tsis txhob tua cov piam thaj siab tom qab noj mov nrog cov insulins ntev ntev, siv tsuas yog luv luv lossis luv luv,
tsuas yog Treshiba yog qhov tsim nyog rau kev txhaj tshuaj ib hnub, tab sis qhov tseeb no tsuas yog tus neeg nkaus xwb, thiab xav tau cov lus qhia tseeb,
Nws yog qhov zoo dua rau nkaug Lantus, Levemir thiab Tujeo ob qho tag kis thaum yav sawv ntxov thiab yav tsaus ntuj, suav cov khoom noj tshuaj raws cov qauv saum toj no.
thaum hloov los ntawm ib qho txuas insulin mus rau lwm tus, nce qhov pib pib los ntawm 30% ntawm tus nqi suav, thiab tom qab 10 hnub, kuaj xyuas nws qhov tseeb - yog tias tsim nyog, nce lossis tsawg.

Txoj kev kho mob zoo tshaj plaws rau ntshav qab zib hom 1 thiab ntshav qab zib hom 2 yog kev sib xyaw ntawm cov tshuaj noj zaub mov noj kom tsawg thiab xaiv cov koob tshuaj tsawg kawg nkaus, ob qho txuas ntxiv thiab luv lossis ultra luv luv cov tshuaj insulin. Zoo, txhawm rau lub cev qhov hnyav, kov yeej lossis tiv thaiv kev txhim kho ntawm cov tshuaj insulin hauv cov leeg, nrog rau kev tiv thaiv kev mob ntshav qab zib, tsis muaj kev tawm dag zog - kev tawm dag zog ntawm kev tawm dag zog thiab kev cob qhia cardiocyclic - koj tsis tuaj yeem ua.

Nws muaj peev xwm ua neej nyob nrog kev mob ntshav qab zib hom 1 thiab rov qab los ntawm hom ntshav qab zib hom 2, tab sis qhov no yuav tsum muaj hlau yuav thiab kev qhuab qhia. Hauv nws tus kheej, tsuas yog mob ntshav qab zib hauv lub cev ntawm cov poj niam cev xeeb tub yuav dhau, tab sis nws yog qhov ua rau kev txhawj xeeb txog kev txhim kho, dhau sijhawm, ntawm T2DM.

Vim li cas nws yog ib qho tseem ceeb rau cov neeg mob ntshav qab zib ua raws li tsis yog kev noj zaub mov noj nkaus xwb, tab sis muaj ntau yam zaub mov kom tsawg, thiab rau cov niam hluas uas muaj ntshav qab zib tsis txaus los zaum saum nws thaum pub niam mis, cov yeeb yaj kiab no piav qhia.

Insulin Lantus yog ib hom tshuaj uas muaj suab thaj hauv lub cev. Tus nquag ua hauj lwm yog insulin glargine. Qhov no yog ib qho piv txwv ntawm tib neeg cov kua dej, uas tsis zoo rau hauv kev cuam tshuam hauv nruab nrab. Hauv cov khw muag tshuaj koj tuaj yeem pom 3 daim ntawv ntawm kev tso tawm cov tshuaj: OptiSet syringe cwj mem, OptiClick thiab Lantus SoloStar tshuab. Dab tsi yog cov yam ntxwv ntawm kev siv tshuaj?

Cov tshuaj Insulin Lantus muaj cov nyhuv ntev ntev, txhim kho cov metabolism hauv cov piam thaj thiab tswj cov metabolism hauv kev ua kom rog. Thaum noj tshuaj, qab zib kom tsawg los ntawm cov nqaij thiab cov nqaij rog yog ceev. Tsis tas li, tus neeg sawv cev hormonal ua kom cov protein ntau. Tib lub sijhawm, proteolysis thiab lipolysis hauv adipocytes yog inhibited.

Cov Yuav Tsum Tau Ua

Contraindicated nyob rau hauv cov intolerance mus rau lub active tshuaj los yog lub koom haum pab. Rau cov tub ntxhais hluas, cov tshuaj tau hais tawm tsuas yog thaum lawv muaj 16 xyoo.

Kev saib xyuas tshwj xeeb yuav tsum tau coj thaum tsim kev loj hlob ntawm cov hlab ntsha hlwb ntau dua, kom lub cev ntawm cov hlab ntshav thiab cov hlab ntsha. Kev tshuaj ntsuam mob kuj tseem ceeb rau cov neeg mob uas cov tsos mob ntawm lub qog ntshav qab zib. Tus kab mob no tuaj yeem raug npog los ntawm kev puas siab puas ntsws, leeg mob hlwb, ntshav qab zib ntev.

Raws li cov lus qhia nruj, nws yog tshuaj rau cov neeg laus. Tib yam siv rau cov neeg uas tau hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg.

Kuv puas tuaj yeem txhaj Lantus hmo ntuj thiab tib lub sijhawm ultrashort insulin ua ntej noj hmo?

Raug cai - koj tuaj yeem ua tau.Txawm li cas los xij, yog tias koj muaj teeb meem nrog ntshav qab zib thaum sawv ntxov nyob rau ntawm lub plab khoob, nws raug nquahu kom txhaj Lantus thaum tsaus ntuj kom ntxov li ntxov tau ua ntej yuav mus pw. Cov tshuaj insulin sai ua ntej noj hmo, koj yuav tsum nkag rau ob peb teev ua ntej.

Nws yog ib qho tseem ceeb uas koj nkag siab txog lub hom phiaj ntawm txhua yam kev txhaj tshuaj uas teev rau hauv nqe lus nug. Koj kuj yuav tsum muaj peev xwm xaiv qhov kev xaiv qhov tseeb ntawm cov tshuaj insulin cov kev npaj sai thiab ncua ntev. Nyeem tsab xov xwm "" rau cov ntsiab lus ntawm luv luv thiab ultrashort npaj.

Cov mob ntshav qab zib rau hom 2 ntshav qab zib

Lantus tuaj yeem yog cov tshuaj uas insulin kho mob rau tus mob ntshav qab zib hom 2 pib nrog. Ua ntej tshaj plaws, lawv txiav txim siab ntawm kev txhaj tshuaj ntawm cov tshuaj insulin no thaum tsaus ntuj, thiab tom qab ntawd thaum sawv ntxov. Yog tias cov piam thaj txuas ntxiv tom qab noj mov tas, lwm qhov luv luv lossis ib qho tshuaj ntxiv rau hauv kev kho mob insulin - Actrapid, Humalog, NovoRapid lossis Apidra.

Dr. Bernstein tawm tswv yim txhawm rau txhawm rau saib cov tshuaj txhua hnub rau 2 tshuaj - thaum yav tsaus ntuj thiab sawv ntxov. Txawm hais tias muaj pes tsawg tus txhaj tshuaj tsis txo, hloov mus rau Tresib insulin tseem siv tau. Vim tias cov ntshav qab zib cov ntshav yuav zoo tuaj. Lawv yuav dhau los ua neeg ruaj khov.

Cov tshuaj insulin twg zoo dua: Lantus lossis Tujeo? Dab tsi yog qhov txawv ntawm ob?

Nws muaj cov tshuaj qub zoo ib yam li Lantus - insulin glargine. Txawm li cas los xij, kev mloog zoo ntawm insulin hauv Tujeo txoj kev daws teeb meem yog 3 zaug siab dua - 300 IU / ml. Hauv txoj ntsiab cai, koj tuaj yeem txuag me ntsis yog tias koj mus rau Tujeo. Txawm li cas los xij, nws zoo dua tsis yog. Kev ntsuam xyuas ntshav qab zib ntawm Tujeo cov tshuaj insulin feem ntau tsis zoo. Hauv qee tus neeg mob, tom qab hloov los ntawm Lantus mus rau Tujeo, cov ntshav qab zib cov ntshav nce siab, hauv lwm tus, vim qee yam, insulin tshiab dheev tsis ua haujlwm. Vim nws lub siab, nws feem ntau quaj thiab kaw qhov muag ntawm rab koob xaum hluav taws xob. Tujeo ua rau raug txom nyem tsis yog nyob hauv tsev, tab sis kuj hais lus Askiv-cov lus ntshav qab zib sib tham. Yog li ntawd, yog tias ua tau, nws yog qhov zoo dua los txuas ntxiv laim lantus yam tsis hloov nws. Nws tsim nyog hloov mus rau cov laj thawj piav qhia saum toj no.

Cov tshuaj insulin twg zoo dua: Lantus lossis Levemir?

Ua ntej tawm tsam insulin, Dr. Bernstein tau siv ntau xyoo, tsis yog Lantus. Thaum xyoo 1990, muaj qee cov xwm txheej tau pom, hais tias Lantus nce qee qhov kev pheej hmoo ntawm qee yam mob qog ntshav. coj lawv qhov kev sib cav sib ceg tiag, nres txhaj tshuaj insulin glargin rau nws tus kheej thiab muab tshuaj rau cov neeg mob. Lub chaw tsim khoom lag luam pib fuss - thiab nyob rau xyoo 2000 muaj ntau yam hauv tsab xov xwm thov tias cov tshuaj Lantus muaj kev nyab xeeb. Feem ntau cov yuav muaj, txawm hais tias insulin glargine ua rau muaj kev pheej hmoo ntawm qee yam mob qog nqaij hlav, tom qab ntawd me ntsis. Qhov no yuav tsum tsis yog ib qho laj thawj los mus rau Levemire.

Yog tias koj nkag rau Lantus thiab Levemir hauv tib lub koob tshuaj, tom qab ntawd qhov kev txiav txim ntawm kev txhaj tshuaj ntawm Levemir yuav xaus nrawm dua. Nws raug pom zoo kom txhaj Lantus ib hnub ib zaug, thiab Levemir - 1 lossis 2 zaug ib hnub. Txawm li cas los xij, hauv kev coj ua, ob qho tshuaj yuav tsum tau txhaj 2 zaug hauv ib hnub, sawv ntxov thiab yav tsaus ntuj. Kev txhaj ib hnub yog tsis txaus. Xaus: yog tias Lantus lossis Levemir haum rau koj tau zoo, txuas ntxiv siv nws. Hloov mus rau Levemir yuav tsum ua yog tias tsim nyog kiag li. Piv txwv, yog ib hom insulin ua rau ua xua lossis nws tsis raug muab pub dawb. Txawm li cas los xij, qhov no yog lwm yam teeb meem. Nws ua ntau yam zoo dua. Nws tsim nyog hloov mus rau yog tias tus nqi siab tsis nres nws.

Cov neeg mob yuav tsum qhia lawv tus kws kho mob txog kev xeeb tub tam sim no lossis npaj yuav muaj lub zog.

Tsis muaj ib qho kev sim kho mob sib kis ntawm kev siv tshuaj insulin glargine rau cov poj niam cev xeeb tub.

Ntau qhov kev soj ntsuam (ntau tshaj 1000 qhov tshwm sim ntawm cev xeeb tub hauv kev rov ua dua tshiab thiab kev cia siab yav tom ntej) nrog kev tshaj tawm tom qab kev siv tshuaj tua kab mob insulin glargine tau qhia tias nws tsis muaj teebmeem tshwj xeeb rau ntawm chav kawm thiab cov txiaj ntsig ntawm cev xeeb tub lossis ntawm kev mob ntawm menyuam, lossis kev noj qab haus huv ntawm tus menyuam mos.

Tsis tas li ntawd, txhawm rau txheeb xyuas kev nyab xeeb ntawm insulin glargine thiab insulin-isophan siv rau cov poj niam cev xeeb tub nrog tus mob ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, cov meta-tsom xam ntawm yim soj ntsuam kev soj ntsuam tau ua tiav, suav nrog cov poj niam uas siv insulin glargine thaum cev xeeb tub (n = 331) thiab cov tshuaj insulin isophane (n = 371).

Qhov tsom xam no tsis qhia txog qhov sib txawv txog kev nyab xeeb ntawm leej niam lossis kev noj qab haus huv tshiab thaum siv tshuaj insulin glargine thiab insulin-isophan thaum cev xeeb tub.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib mellitus, nws yog ib qho tseem ceeb kom muaj kev cai tsim nyog ntawm cov khoom noj hauv lub cev thoob plaws lub cev xeeb tub kom tiv thaiv qhov pom ntawm qhov tsis xav tau tshwm sim cuam tshuam nrog hyperglycemia.

Cov tshuaj Lantus® SoloStar ® tuaj yeem siv thaum cev xeeb tub rau kev kuaj mob.

Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab, feem ntau, nce ntxiv thaum txiav thib ob thiab peb feem plaub.

Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, kev saib xyuas kev saib xyuas ntawm cov ntshav qabzib hauv cov ntshav yog qhov tseem ceeb.

Cov neeg mob lub cev thaum lactation yuav tau kho cov tshuaj ntau dua ntawm cov tshuaj insulin thiab kev noj haus.

Hauv cov kev tshawb fawb tsiaj, tsis muaj cov ntaub ntawv ncaj qha lossis tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine.

Txog tam sim no, tsis muaj txheeb cais hais txog kev siv cov tshuaj thaum cev xeeb tub. Muaj pov thawj ntawm kev siv Lantus hauv 100 tus poj niam cev xeeb tub muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin.

Kev teem caij ntawm Lantus hauv cov poj niam cev xeeb tub yuav tsum tau ua nrog ceev faj. Rau cov neeg mob uas muaj kab mob ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev cai tsim nyog ntawm cov khoom noj hauv lub cev thoob plaws lub cev xeeb tub.

Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab).

Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Hauv cov pojniam muaj menyuam, kev txhaj tshuaj thiab noj zaub mov kom haum.

Cov txiaj ntsig tsis zoo ntawm cov tshuaj hauv lub cev ntawm cov poj niam cev xeeb tub thiab tus me nyuam hauv plab tsis tau lees paub los ntawm kev tshawb fawb soj ntsuam. Txawm li cas los xij, cov poj niam lub sijhawm nyob rau lub sijhawm muaj menyuam yaus yuav tsum siv cov tshuaj nrog kev ceev faj, soj ntsuam nruj kev noj tshuaj uas tus kws kho mob tuaj koom.

Thaum noj cov tshuaj no, cov poj niam cev xeeb tub yuav tsum tau kuaj ntshav tas li kom tswj hwm cov ntshav qab zib hauv lub cev. Thawj 3 lub hlis uas cev xeeb tub, lub cev xav tau cov tshuaj insulin tuaj yeem txo qis, tab sis nyob rau lub sijhawm thib 2 thiab 3 nws tuaj yeem nce ntxiv. Tom qab yug tus me nyuam, xav tau cov tshuaj dua ib zaug tsawg zuj zus, uas cuam tshuam nrog kev hloov hauv keeb kwm yav dhau los.

Ntev ntshav Insulin - Nta ntawm Kev Kho Mob Ntshav Qab Zib

Nrog rau tus kab mob, ntshav qab zib yuav tsum tau txais kev txhawb nqa insulin. Cov tshuaj insulin luv thiab insulin ntev ntev raug siv los kho tus mob. Qhov zoo ntawm lub neej ntawm cov ntshav qab zib feem ntau nyob ntawm kev ua raws li tag nrho cov tshuaj kho mob.

Yuav tsum siv cov insulin txuas mus tau sai thaum yoo cov ntshav cov piam thaj kom yuav tsum hloov kho. Cov insulins uas siv tau ntev tshaj plaws rau hnub no yog Levemir thiab Lantus, uas tus neeg mob yuav tsum tau noj ib zaug txhua 12 lossis 24 teev.

Cov insulin ntev ntev muaj qhov cuab yeej zoo, nws muaj peev xwm ntsi xws li lub cev ntuj tsim uas tsim los ntawm cov hlwb ntawm cov txiav.Tib lub sijhawm, nws yog maj rau ntawm cov hlwb zoo li ntawd, txhawb lawv txoj kev zoo rov los, uas yav tom ntej tso cai tsis kam hloov kho insulin.

Kev hno cov tshuaj insulin ntev ntev yuav tsum tau muab rau cov neeg mob uas muaj qib siab qab zib thaum nruab hnub, tab sis nws yuav tsum xyuas kom tus neeg mob noj zaub mov tsis pub dhau 5 teev ua ntej yuav mus pw. Tsis tas li, cov insulin ntev yog tsim rau cov tsos mob ntawm "thaum sawv ntxov kaj ntug", nyob rau hauv rooj plaub thaum lub siab pib pib thaum hmo ntuj ua ntej tus neeg mob sawv, ua kom cov insulin tsis muaj teebmeem.

Yog hais tias luv luv insulin xav tau txhaj thaum nruab hnub kom txo tau cov ntshav qabzib nrog cov zaub mov, tom qab ntawd cov insulin ntev lav rau insulin keeb kwm yav dhau los, ua qhov kev tiv thaiv zoo tshaj plaws ntawm ketoacidosis, thiab nws kuj tseem pab kom rov qab zoo ntawm cov ntshav qab zib.

Kev hno ntshav ntawm cov tshuaj insulin ntev tsim nyog tau txais kev mloog rau qhov lawv pab ua rau tus neeg mob tus kheej ib txwm muaj thiab xyuas kom meej tias cov ntshav qab zib hom 2 tsis dhau rau thawj hom kab mob.

Qhov tseeb muab xam ntawm cov koob tshuaj ntawm cov insulin ntev thaum hmo ntuj

Txhawm rau kom lub neej tsis muaj sia nyob, tus neeg mob yuav tsum tau kawm kom paub tseeb ntsuas qhov ntau thiab tsawg ntawm Lantus, Protafan lossis Levemir thaum hmo ntuj, kom cov qib nrawm nrawm nrog rau ntawm 4.6 ± 0.6 mmol / l.

Ua li no, nyob hauv lub limtiam koj yuav tsum ntsuas qib suab thaj thaum hmo ntuj thiab sawv ntxov thaum lub plab khoob. Tom qab ntawd koj yuav tsum xam qhov txiaj ntsig ntawm qab zib thaum sawv ntxov tshaj tawm nag hmo tus nqi thaum hmo ntuj thiab suav qhov nce qhov nce, qhov no yuav muab qhov ntsuas ntawm qhov tsawg kawg yuav tsum tau noj.

Piv txwv li, yog tias qhov nce qib ntawm thaj thaj kom tsawg tshaj plaws yog 4.0 mmol / l, tom qab ntawd 1 ntu ntawm cov tshuaj insulin ntev tuaj yeem txo qhov ntsuas no los ntawm 2.2 mmol / l hauv ib tus neeg hnyav 64 kg. Yog tias koj qhov hnyav hnyav 80 kg, tom qab ntawd peb siv cov qauv hauv qab no: 2.2 mmol / L * 64 kg / 80 kg = 1.76 mmol / L.

Qhov koob tshuaj ntawm cov tshuaj insulin rau ib tus neeg uas hnyav 80 kg yuav tsum yog 1.13 units, tus lej no yog muab kwv yees mus rau lub quarter ze thiab peb tau txais 1.25E.

Nws yuav tsum raug sau tseg tias Lantus tsis tuaj yeem raug diluted, yog li nws yuav tsum tau txhaj nrog 1ED lossis 1,5ED, tab sis Levemir tuaj yeem raug txhaws thiab txhaj nrog tus nqi uas yuav tsum tau ua. Hauv ob peb hnub tom qab no, koj yuav tsum tau soj ntsuam seb cov piam thaj sai npaum li cas thiab yuav ua rau ntau ntxiv lossis ntau npaum li cas.

Nws yog xaiv qhov raug thiab raug yog tias, hauv ib lub lis piam, cov piam thaj sai dua tsis tshaj 0.6 mmol / l, yog tias tus nqi ntau dua, tom qab ntawd sim nce qhov ntau npaum ntawm 0.25 units txhua peb hnub.

Thaum yuav siv cov tshuaj

Ib cov tshuaj yog siv rau cov ntshav qab zib, uas yuav tsum tau kho nrog insulin. Ntau zaus nws yog ntshav qab zib hom 1. Qhov tshuaj hormone no tuaj yeem kho rau txhua tus neeg mob uas muaj hnub nyoog 6 xyoo.

Kev siv tshuaj insulin ntev ntev yog qhov tsim nyog los tswj lub cev ceev ceev hauv cov ntshav cov neeg mob cov ntshav. Tus neeg noj qab haus huv hauv cov hlab ntshav yeej ib txwm muaj qee qhov ntawm no, xws li cov ntsiab lus hauv cov ntshav yog hu ua theem pib.

Hauv cov neeg mob uas muaj ntshav qab zib mellitus nyob rau hauv rooj plaub ntawm pancreatic kawg, xav tau cov tshuaj insulin, uas yuav tsum tau txhaj tshuaj tsis tu ncua.

Lwm qhov kev xaiv rau kev tso tawm cov tshuaj hormone hauv ntshav tau hu ua bolus. Nws cuam tshuam nrog kev noj mov - hauv kev teb rau kev nce siab hauv cov ntshav qab zib, qee qhov ntshav ntawm insulin raug tso tawm kom sai glycemia li qub.

Hauv cov ntshav qab zib mellitus, insulins luv luv tau siv rau qhov no. Hauv qhov no, tus neeg mob yuav tsum txhaj nws tus kheej nrog rab koob txhaj tshuaj txhua lub sijhawm tom qab noj mov, nws muaj cov khoom tsim nyog ntawm cov tshuaj hormones.

Hauv cov tsev muag tshuaj, coob tus muab tshuaj sib txawv rau kev kho mob ntshav qab zib tau muag. Yog tias tus neeg mob xav tau siv lub cev ntev ua cov tshuaj hormones, tom qab ntawd dab tsi yog qhov zoo siv - Lantus lossis Levemir? Ntau txoj hauv kev, cov tshuaj no zoo sib xws - ob qho tib si yog qhov pib, yog qhov ua kwv yees thiab ruaj khov nyob rau hauv kev siv.

Cia peb pom tias cov tshuaj hormones no txawv li cas.Nws ntseeg tias Levemir muaj lub neej ua haujlwm ntev dua li Lantus Solostar - txog 6 lub lim tiam tiv thaiv ib hlis. Yog li no, Levemir pom tau tias yooj yim dua rau kis uas koj xav tau nkag rau qhov qis ntawm cov tshuaj, piv txwv li, ua raws li cov zaub mov uas tsis muaj cov carb qis.

Cov kws txawj hais tias Lantus Solostar yuav ua rau muaj kev pheej hmoo mob qog noj ntshav, tab sis tsis muaj ntaub ntawv txaus ntseeg ntawm qhov no tseem.

Glargin thiab lwm yam tshuaj

Kev sib xyaw nrog lwm cov tshuaj cuam tshuam rau cov txheej txheem metabolic txuam nrog cov piam thaj:

Qee cov tshuaj txhim kho cov nyhuv ntawm Lantus. Cov no suav nrog sulfonamides, salicylates, tshuaj noj ntawm qhov ncauj-txo qhov ncauj, ACE thiab MAO inhibitors, thiab lwm yam.
Diuretics, sympathomimetics, protease inhibitors, antipsychotics nkaus xwb, cov tshuaj hormones - poj niam, cov thyroid, thiab lwm yam tsis muaj zog cov kev cuam tshuam ntawm insulin glargine.
Kev nqus cov roj ntsha lithium, kev tiv thaiv beta-blockers lossis kev haus cawv ua rau muaj qhov tsis meej xwm - txhim kho lossis txo cov nyhuv ntawm cov tshuaj.
Noj pentamidine nyob rau hauv parallel nrog Lantus ua rau muaj kev ntsia hlau loj nyob rau hauv cov piam thaj, qhov kev hloov pauv ntse los ntawm ib qho zuj zus mus rau qhov nce.

Feem ntau, cov tshuaj muaj cov tshuaj xyuas zoo. Tus nqi insulin glargin raug nyiaj npaum li cas? Tus nqi ntawm cov nyiaj hauv thaj tsam thaj tsam li 2500-4000 rubles.

Peb yuav txheeb xyuas seb yuav siv Lantus li cas - cov lus qhia rau kev siv hais tias nws yuav tsum tau txhaj tshuaj rau hauv cov ntaub so ntswg ntawm lub plab phab ntsa sab xub ntiag, thiab nws tsis tuaj yeem siv tshuaj ntxau. Qhov qauv ntawm cov tshuaj saib xyuas yeeb tshuaj no yuav ua rau txo qis cov ntshav qabzib hauv lub ntsej muag thiab kev txhim kho ntawm lub ntsej muag hypoglycemic.

Ntxiv nrog rau fiber ntau ntawm lub plab, muaj lwm qhov chaw rau qhov kev qhia tau ntawm Lantus - cov pob txha hauv plab, cov leeg nqaij deltoid. Qhov sib txawv hauv cov nyhuv hauv cov xwm txheej no tsis txaus ntseeg lossis tsis tuaj kiag li.

Qhov tshuaj tsis tuaj yeem ua ke ua ke nrog lwm cov tshuaj insulin, nws tsis tuaj yeem xeb ua ntej siv, vim qhov no txo nws cov hauj lwm zoo. Yog tias sib xyaw nrog lwm cov tshuaj pharmacological, dej nag yog tau.

Txhawm rau kom ua tau zoo kho mob, Lantus yuav tsum tau siv txuas ntxiv, txhua txhua hnub nyob rau tib lub sijhawm.

Yuav siv hom tshuaj insulin li cas rau cov ntshav qab zib, kws kho mob endocrinologist yuav qhia koj. Muaj qee kis, kev siv yeeb-tshuaj luv luv tuaj yeem muaj peev xwm kis nrog qee zaum; qee zaum yuav tsum tau muab ob qho tshuaj insulins luv thiab ntev ntev. Ib qho piv txwv ntawm kev sib koom ua ke no yog kev sib koom ua ke ntawm Lantus thiab Apidra, lossis kev sib txuam xws li Lantus thiab Novorapid.

Hauv cov xwm txheej ntawd thaum, rau qee qhov laj thawj, nws yuav tsum hloov cov tshuaj Lantus Solostar hloov mus rau lwm qhov (piv txwv, rau Tujeo), qee cov cai yuav tsum tau ua raws. Qhov tseem ceeb tshaj plaws, kev hloov pauv yuav tsum tsis txhob muaj kev nyuaj siab loj rau lub cev, yog li koj tsis tuaj yeem txo qis dua ntawm cov tshuaj raws li cov lej ntawm qhov kev txiav txim.

Ntawm qhov tsis sib xws, hauv thawj hnub ntawm kev tswj hwm, kev nce ntxiv ntawm cov tshuaj insulin yog qhov ua tau kom thiaj li yuav zam tau hyperglycemia. Thaum txhua lub cev hloov mus rau txoj kev siv tshuaj tshiab zoo tshaj plaws, koj tuaj yeem txo qhov koob tshuaj rau tus nqi ib txwm.

Txhua yam kev hloov pauv hauv txoj kev kho, tshwj xeeb yog cov cuam tshuam nrog kev hloov cov tshuaj nrog cov tshuaj tiv thaiv kab mob analogues, yuav tsum pom zoo nrog cov kws kho mob koom nrog, uas paub tias ib hom tshuaj txawv ntawm lwm thiab qhov twg zoo dua.

Qhov yuav tsum tau siv rau lwm pab pawg ntawm cov tshuaj rau kev kho mob yuav tsum tau ceeb toom ua ntej rau tus kws kho mob uas koom nrog. Qee cov tshuaj, sib cuam tshuam nrog Lantus, txhim kho nws cov nyhuv, thaum lwm tus, ntawm qhov tsis tooj, inhibit nws, ua rau nws tsis tuaj yeem tau txais kev kho kom zoo.

Cov tshuaj uas txhim kho qhov kev txiav txim ntawm Lantus:

inhibitors
antimicrobial tus neeg sawv cev
ib pawg ntawm salicylates, fibrates,
Fluoxetine.

Lawv txoj kev tswj hwm ib txhij yuav ua rau muaj kev cuam tshuam cov ntshav qab zib thiab ntshav sib tsoo. Yog tias nws tsis tuaj yeem thim cov nyiaj no, nws yog ib qho tsim nyog yuav tau kho cov tshuaj ntawm cov tshuaj insulin.

Kev qaug zog ntawm qhov ua tau zoo ntawm cov tshuaj tuaj yeem tshwm sim thaum nws cuam tshuam nrog cov tshuaj diuretic, ib pawg estrogens thiab progestogens, thiab atypical antipsychotics. Cov tshuaj hormones kho mob los kho cov pathology ntawm cov thyroid caj pas thiab endocrine system tuaj yeem ua kom cov nyhuv hypoglycemic ntawm Lantus.

Nws raug nquahu kom tsis txhob haus dej haus cawv thiab siv cov tshuaj ntawm pawg beta-blocker rau kev kho mob, uas tuaj yeem txo ob txoj kev ua haujlwm ntawm cov tshuaj thiab ua rau glycemia, nyob ntawm qhov ntau thiab cov cim ntawm tus neeg mob lub cev.

Kev sib txuam tshuaj nrog ntau cov tshuaj tuaj yeem cuam tshuam cov metabolism hauv cov piam thaj. Cov tshuaj hauv qab no cuam tshuam rau kev nqis tes ntawm Lantus raws li cov lus qhia:

Cov tshuaj uas txhim kho qhov kev ua ntawm Lantus (insulin glargine) - ACE inhibitors, tshuaj tiv thaiv hypoglycemic, MAO inhibitors, fluoxetine, fibrates, disopyramides, propoxyphene, pentoxifylline, sulfonamide tshuaj thiab salicylates,
Cov tshuaj uas ua rau cov nyhuv tsis muaj zog ntawm Lantus (insulin glargine) - GCS, diazoxide, danazole, diuretics, gestagens, estrogens, glucagon, isoniazid, somatotropin, phenothiazine derivatives, sympathomimetics (epinephrine, terbutaline, salbutamolum), protease inhibitors los yog qee yam tshuaj tiv thaiv nerogen. cov thyroid hormones
Ob leeg txhim kho thiab ua kom cov nyhuv ntawm Lantus (insulin glargine) beta-blockers, lithium ntsev, clonidine, cawv,
Qhov tsis txaus ntseeg ntawm cov piam thaj hauv ntshav nrog kev hloov pauv ntawm hypoglycemia rau hyperglycemia tuaj yeem ua rau tib lub sijhawm tswj hwm ntawm Lantus nrog pentamidine,
Cov tsos mob ntawm adrenergic counterregulation tuaj yeem txo lossis ncua sijhawm thaum noj cov tshuaj sympatholytic - guanfacin, clonidine, reserpine thiab beta-blockers.

Tsuas tshuaj thiab tswj hwm

Lantus® muaj cov tshuaj insulin glargine - ib qho tshuaj insulin zoo ib yam nrog kev ua ntev. Lantus® yuav tsum siv ib hnub ib zaug, txhua lub sijhawm ntawm lub hnub, tab sis tib lub sijhawm, txhua hnub.

Qhov ntau npaum cov tshuaj (koob thiab lub sijhawm ntawm kev tswj hwm) ntawm Lantus yuav tsum tau xaiv ib tus zuj zus. Rau cov neeg mob ntshav qab zib hom 2, Lantus® kuj tseem siv tau cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj thiab.

Cov kev ua ntawm cov tshuaj no yog qhia hauv cov koog. Cov koog no muaj cov yam ntxwv tsuas yog rau Lantus thiab tsis zoo ib yam rau ME thiab cov koog tau siv los nthuav qhia lub zog ntawm kev ua ntawm lwm cov tshuaj insulin (saib Pharmacodynamics).

Cov neeg laus laus (≥ 65 xyoo)

Hauv cov neeg laus neeg mob, qhov ua kom lub raum txo qis dua tuaj yeem ua rau txo qis qis ntawm cov tshuaj insulin.

Lub raum khiav tsis zoo

Hauv cov neeg mob uas lub raum khiav tsis zoo, insulin thov yuav txo qis vim muaj cov tshuaj insulin metabolism tsis ua haujlwm.

Tsis zoo hepatic muaj nuj nqi

Hauv cov neeg mob uas muaj lub siab ua haujlwm tsis txaus siab, qhov xav tau rau insulin tuaj yeem txo vim muaj peev xwm txo qis gluconeogenesis thiab txo cov tshuaj insulin metabolism.

Kev nyab xeeb thiab muaj txiaj ntsig ntawm cov tshuaj Lantus® tau muaj pov thawj hauv cov neeg hluas thiab menyuam yaus hnub nyoog 2 xyoos thiab laus dua (saib "Pharmacodynamics"). Lantus® tsis tau kawm hauv cov menyuam yaus hnub nyoog qis dua 2 xyoos.

Hloov los ntawm lwm yam insulin rau Lantus®

Thaum hloov cov tshuaj kho nrog qhov nruab nrab ntev lossis insulin ua haujlwm ntev nrog kev kho Lantus, nws yuav tsum tau hloov cov tshuaj ntawm cov tshuaj insulin basal thiab kho cov tshuaj tiv thaiv kab mob nyob rau tib lub sijhawm (koob tshuaj thiab lub sijhawm ntawm kev saib xyuas cov yeeb yam luv luv lossis cov tshuaj insulin sai sai, lossis cov tshuaj ntawm qhov ncauj tiv thaiv kab mob cov nyiaj).

Yuav kom txo qis kev pheej hmoo hmo ntuj los yog thaum sawv ntxov ntxov tsis txhob mob ntshav qab zib, cov neeg mob hloov los ntawm kev coj cov tshuaj insulin NPH hloov mus rau ib qho kev noj tshuaj nrog Lantus yuav tsum txo qis cov tshuaj txhua hnub ntawm basal insulin los ntawm 20-30% hauv thawj lub lis piam ntawm kev kho mob.

Hauv thawj lub lis piam, qhov kev txo koob tshuaj yuav tsum yog qhov tsawg kawg yog qee los them ntxiv los ntawm kev nce lub koob tshuaj insulin uas siv thaum noj mov, tom qab lub sijhawm no, cov kev tswj hwm yuav tsum tau kho kho kom haum.

Ib yam li lwm yam tshuaj insulin, hauv cov neeg mob tau txais insulin ntau vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov insulin, nws muaj peev xwm txhim kho cov lus teb rau insulin thaum kho mob nrog Lantus.

Thaum lub sij hawm hloov mus rau Lantus® thiab hauv thawj lub lis piam tom qab nws, kev soj ntsuam nruj ntawm cov ntsuas kev ntsuas yog xav tau.

Raws li kev tswj metabolic txhim kho thiab, vim li ntawd, cov ntaub so ntswg rhiab heev rau insulin nce, yuav tsum tau kho ntxiv koob tshuaj. Kev hloov kho koob tshuaj kuj yuav tsim nyog, piv txwv, nrog kev hloov ntawm tus neeg mob lub cev qhov hnyav lossis kev ua neej, nrog rau kev hloov lub sijhawm ntawm insulin tswj hwm thiab nrog rau lwm yam, tau tshwm sim tshiab uas ua rau muaj qhov tsis txaus siab rau hypoglycemia lossis hyperglycemia (saib "Cov lus qhia tshwj xeeb").

Lantus® yuav tsum tau tswj hwm subcutaneously. Yuav tsum tsis txhob muab lub lantus® tso ncaj nruab nrog txoj leeg. Lub caij nyoog ntev ua haujlwm ntawm Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous. Kev tswj hwm ntawm cov tshuaj subcutaneous li niaj zaus tuaj yeem ua rau mob ntshav qab zib heev. Tsis muaj qhov sib txawv hauv qhov chaw kho mob hauv cov ntshav insulin lossis cov piam thaj tom qab kev tswj hwm ntawm Lantus mus rau lub plab phab ntsa, deltoid cov leeg, lossis ncej puab. Nws yog ib qho tsim nyog yuav tsum hloov chaw txhaj tshuaj nyob rau thaj chaw ib zaug. Lub lantus® yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin lossis diluted. Kev sib xyaw thiab kev zom zaws tuaj yeem hloov kho lub sijhawm / kev ua ub no; kev sib xyaw tuaj yeem ua rau dej nag. Yog xav paub cov lus qhia ntxaws ntxaws ntawm kev siv tshuaj, saib hauv qab.

Cov lus qhia tshwj xeeb rau kev siv

Daim phiajcim daim roj tsheb yuav tsum siv tshwj xeeb nrog OptiPen®, ClickSTAR®, Autopen® 24 tus tes tuav (saib “Cov Lus Qhia Tshwj Xeeb”).

Cov tuam txhab cov lus qhia rau kev tuav tus cwj mem hais txog lub laub ntim cov khoom thauj, rab koob khawm, thiab cov tshuaj insulin yuav tsum ua raws cai.

Yog hais tias tus insulin cwj mem raug puas ntsoog lossis ua haujlwm tsis zoo (vim muaj cov tshuab tsis zoo), nws yuav tsum tau muab pov tseg thiab tus cwj mem insulin tshiab yuav tsum siv.

Yog tias tus cwj mem tsis ua haujlwm zoo (saib cov lus qhia rau kev tuav tus cwj mem), tom qab ntawd cov tshuaj yuav tawm ntawm lub taub ntim mus rau hauv cov koob txhaj tshuaj (haum rau insulin 100 units / ml) thiab txhaj.

Ua ntej nkag rau hauv tus cwj mem, lub thawv ntawv yuav tsum khaws cia rau 1-2 teev ntawm chav sov.

Tshawb xyuas daim cartridge ua ntej siv. Nws tuaj yeem siv tsuas yog daws tau pob tshab, tsis muaj kob, tsis muaj cov khoom sib xyaw pom thiab muaj cov dej tsis sib xws. Vim tias Lantus® yog ib qho kev daws teeb meem, nws tsis tas yuav rov qab ua ntej siv.

Lub lantus® yuav tsum tsis txhob sib xyaw nrog lwm cov insulin lossis diluted. Kev sib xyaw lossis kev sib xyaw ua ke tuaj yeem hloov nws cov qauv ntawm sab cev / ua haujlwm; kev sib xyaw ua ke yuav ua rau nag lossis daus.

Cov pa npuas yuav tsum tau muab tshem tawm ntawm daim cartridge ua ntej txhaj tshuaj (saib cov lus qhia coj ua). Lub laub ntim tsis tau ntim tsis tau.

Cwjmem yuav tsum tau siv nrog Lantus® cartridges. Lantus® cartridges yuav tsum siv tshwj xeeb nrog cov cwj mem hauv qab no: OptiPen®, ClickSTAR® thiab Autopen® 24, lawv yuav tsum tsis txhob siv nrog lwm tus cwjmem rov siv tau, vim tias qhov ntau npaum li cas tau tsuas yog ntseeg tau nrog cov npiv uas tau teev tseg.

Tshawb xyuas cov vial ua ntej siv. Nws tuaj yeem siv tsuas yog daws tau pob tshab, tsis muaj kob, tsis muaj cov khoom sib xyaw pom thiab muaj cov dej tsis sib xws. Vim tias Lantus® yog ib qho kev daws teeb meem, nws tsis tas yuav rov qab ua ntej siv.

Lub lantus® yuav tsum tsis txhob sib xyaw nrog lwm cov insulin lossis diluted. Kev sib xyaw lossis rov qab tuaj yeem hloov kho nws lub sijhawm / kev ua ub no; kev sib xyaw tuaj yeem ua rau dej nag.

Nws yog ib txwm tsim nyog, ua ntej txhua txoj kev txhaj tshuaj, txhawm rau kuaj cov ntawv ntawm insulin thiaj li tsis yuam kev cov tshuaj insulin glargine nrog lwm cov insulins (saib "Cov Lus Qhia Tshwj Xeeb").

Kev tswj hwm tsis raug cai ntawm cov tshuaj

Cov neeg muaj tus mob no tau tshaj tawm thaum cov tshuaj tsis meej pem nrog lwm cov insulins, tshwj xeeb, luv luv ua haujlwm insulins tau txais kev tswj hwm uas tsis yog glargine los ntawm kev ua txhaum. Ua ntej txhua txoj kev txhaj tshuaj, nws yog ib qho tsim nyog yuav tsum kuaj cov tshuaj insulin kom tsis txhob muaj kev kub ntxhov ntawm insulin glargine thiab lwm yam insulins.

Kev sib xyaw ntawm Lantus nrog pioglitazone

Cov kab mob hauv lub plawv tsis ua haujlwm tau paub thaum pioglitazone tau siv nrog kev siv tshuaj insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kev pheej hmoo rau lub plawv tsis ua haujlwm. Qhov no yuav tsum nco ntsoov thaum sau cia ua ke nrog pioglitazone thiab Lantus. Yog tias kev sib koom ua ke tau kho, tus neeg mob yuav tsum tau soj ntsuam cov cim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm, hnyav ntxiv, thiab o Pioglitazone yuav tsum tsis ua mus ntxiv yog tias muaj cov tsos mob ntawm lub plawv tsis zoo.

Cov tshuaj no tsis tuaj yeem sib xyaw nrog lwm cov tshuaj. Nws yog ib qho tseem ceeb tias cov koob txhaj tshuaj tsis muaj kab ke ntawm lwm yam tshuaj.

Sab sij huam

Kev mob ntshav qab zib tsawg, feem ntau cov kev tsis haum siab rau kev kho tshuaj insulin, tuaj yeem txhim kho yog tias cov koob tshuaj insulin ntau dhau piv rau qhov xav tau ntawm cov tshuaj insulin, kev mob ntshav siab tshaj plaws, tshwj xeeb tshaj yog rov ua dua, tuaj yeem ua kev puas tsuaj rau cov hlab ntsha. Ntev los sis ntshav tawm tsam uas muaj ntshav qab zib tsawg tuaj yeem hem tus neeg mob lub neej. Hauv ntau tus neeg mob, cov tsos mob thiab cov tsos mob ntawm tus mob neuroglycopenia yog ua ntej los ntawm cov tsos mob ntawm adrenergic counterregulation. Feem ntau, cov ntshav qabzib ntau dua thiab nrawm nyob hauv cov ntshav txo qis, qhov hais tawm ntau yog qhov tshwm sim ntawm kev tawm tsam thiab nws cov tsos mob.

Cov tshuaj sib cuam tshuam

Tus nab npawb ntawm cov khoom cuam tshuam rau cov metabolism hauv qabzib thiab yuav tsum tsim kom muaj kev kho kom haum ntawm insulin glargine.

Cov yeeb tshuaj uas tuaj yeem txhim kho cov piam thaj hauv kev kho ntshav hauv cov ntshav thiab ua rau muaj kev txo qis rau cov ntshav qab zib hauv lub cev muaj xws li cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, angiotensin-hloov enzyme inhibitors (ACEs), disopyramides, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOs), pentoxifylilides, propylene sulfides thiab propylene.

Cov tshuaj uas yuav ua rau cov ntshav qabzib tsawg nyob rau hauv cov ntshav suav nrog corticosteroid hormones, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens thiab progestogens, phenothiazine derivatives, somatropin, sympathomimetics (e.g. epinephrine (adrenaline), salbutamolide, , atypical tshuaj tiv thaiv kev ua kom tsis haum (xws li, clozapine thiab olanzapine) thiab cov tshuaj tiv thaiv kab mob tiv thaiv kab mob.

Beta-blockers, clonidine, lithium ntsev thiab dej cawv tuaj yeem ob qho kev txhim kho thiab ua kom cov nyhuv tsis muaj ntshav tsis zoo ntawm cov kua dej hauv cov ntshav. Pentamidine tuaj yeem ua rau hypoglycemia, qee zaum tom qab los ntawm hyperglycemia.

Tsis tas li ntawd, nyob rau hauv kev cuam tshuam ntawm cov tshuaj sympatholytic xws li β-blockers, clonidine, guanethidine thiab reserpine, cov cim ntawm adrenergic counterregulation tuaj yeem mob me lossis txawm tias tsis tuaj.

Cev xeeb tub

Cev xeeb tub tsuas yog thaum tsim nyog nkaus xwb. Nws yog ib qho tseem ceeb uas yuav tsum saib xyuas cov qib ntawm cov piam thaj hauv cov ntshav thiab saib xyuas qhov xwm txheej ntawm tus poj niam cev xeeb tub. Hauv thawj peb lub hlis, lub cev xav tau cov tshuaj insulin tsawg dua, thiab hauv rau lub hlis tom ntej no nws nce. Tam sim ntawd tom qab xa khoom tas, qhov xav tau rau cov tshuaj no poob qis zuj zus. Muaj kev pheej hmoo ntawm lub qog ntshav qab zib.

Nrog rau lactation, noj cov tshuaj yog ua tau, tab sis nyob rau hauv kev soj ntsuam tas li ntawm kev ntau npaum. Glargin yog nqus hauv cov hnyuv thiab tawg rau hauv cov amino acids. Nws tsis muaj teebmeem dabtsi rau tus menyuam thaum pub niam mis.

Hloov mus rau Lantus los ntawm lwm hom insulin

Yog tias tus neeg mob yav dhau los siv tshuaj ntawm qhov siab thiab nruab nrab ntawm kev nqis tes ua, tom qab ntawd hloov mus rau Lantus, kev kho qhov tshuaj ntawm cov tshuaj insulin tseem ceeb yog qhov tsim nyog. Yuav tsum tau tshuaj xyuas kom yooj yim.

Thaum ob-lub sij hawm txhaj tshuaj ntawm basal insulin (NPH) raug hloov pauv mus rau kev txhaj tshuaj ib zaug ntawm Lantus, qhov koob tshuaj ntawm thawj zaug poob qis txog 20-30%. Qhov no yog ua thaum thawj 20 hnub ntawm kev kho. Qhov no yuav pab tiv thaiv kom tsis txhob muaj ntshav qab zib thaum hmo ntuj thiab sawv ntxov. Hauv qhov no, lub koob tshuaj tau muab ua ntej noj mov tau nce siab. Tom qab 2-3 lub lis piam, kho cov nqi ntawm cov tshuaj yog nqa tawm ntawm tus kheej rau txhua tus neeg mob.

Hauv lub cev qee cov neeg mob, cov tshuaj tiv thaiv rau tib neeg cov insulin yog tsim tawm. Hauv qhov no, lub cev tiv thaiv kab mob rau Lantus kev txhaj tshuaj hloov pauv. Nws kuj tseem yuav tsum tau rov tshuaj dua.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj noj ntau yam tuaj yeem ob leeg txhim kho cov nyhuv hypoglycemic ntawm Lantus thiab ua kom nws tsis muaj zog. Thawj pab pawg suav nrog cov tshuaj hypoglycemic hauv qhov ncauj, disopyramide, salicylates, propoxyphene, fluoxetine, sulfonamide antimicrobials, monoamine oxidase inhibitors, fibrates thiab pentoxifylline.

Cov nyhuv ua kom tsis muaj zog yog tawm los ntawm danazole, tshuaj tiv thaiv kev tiv thaiv qog, tshuaj loog, glucagon, isoniazid, protease inhibitors, epinephrine, kev loj hlob hormone, salbutamol, phenothiazine, terbutaline, antipsychotics, thyroid hormones, diazoxide.

Qee cov tshuaj muaj cov nyhuv ob npaug ntawm cov cuab yeej hypoglycemic ntawm glargine. Cov no suav nrog pentamidine, beta-blockers, lithium ntsev, clonidine, cawv, guanethidine, reserpine. Ob qhov kawg ntub cov tsos mob ntawm tab tom yuav txo qog ntshav qab zib.

Lantus yog ib qho ntawm thawj qhov tsis muaj kab zauv ntawm tib neeg cov tshuaj insulin. Tau los ntawm kev hloov cov amino acid asparagine nrog glycine ntawm txoj hauj lwm 21st ntawm txoj saw A thiab ntxiv ob lub arginine amino acids hauv cov saw B mus rau lub davhlau ya nyob twg amino acid. Cov tshuaj no yog tsim los ntawm kev lag luam tshuaj Fabkis loj - Sanofi-Aventis. Hauv qhov kev tshawb fawb ntau, nws tau ua pov thawj tias insulin Lantus tsis tsuas yog txo cov kev mob ntshav qab zib tsawg dua piv nrog cov tshuaj NPH, tab sis tseem txhim kho cov metabolism hauv metabolism. Hauv qab no yog cov lus qhia luv luv rau kev siv thiab tshuaj xyuas cov neeg mob ntshav qab zib.

Cov tshuaj nquag ntawm Lantus yog cov tshuaj insulin glargine. Nws kis tau los ntawm kev rov ua dua caj ces siv k-12 leeg kab ntawm cov kab mob Escherichia coli. Hauv qhov nruab nrab nruab nrab, nws yog me ntsis soluble, nyob rau hauv nruab nrab acidic nws yaj nrog kev tsim ntawm microprecipitate, uas tas li thiab maj mam tso cov kua dej. Vim tias qhov no, Lantus tau muaj ib cov profile ua haujlwm ntev txog 24 teev.

Lub ntsiab pharmacological lub zog:

Qeeb qeeb adsorption thiab kev txiav txim siab tsis kawg hauv 24 teev.
Kev txhawb nqa ntawm proteolysis thiab lipolysis hauv adipocytes.
Cov nquag tivthaiv khi rau cov tshuaj insulin 5-8 zaug ntau dua.
Cov kev cai ntawm cov piam thaj hauv cov ntshav, kev txwv tsis pub muaj cov kua nplaum tsim tawm hauv lub siab.

Hauv 1 ml Lantus Solostar muaj:

3.6378 mg ntawm insulin glargine (hauv 100 IU ntawm tib neeg cov tshuaj insulin),
85% glycerol
dej rau kev txhaj tshuaj
hydrochloric concentrated acid,
m-cresol thiab sodium hydroxide.

Kev Hloov mus rau Lantus los ntawm lwm yam insulin

Yog hais tias tus mob ntshav qab zib tau siv cov tshuaj insulins-nruab nrab, tom qab ntawd thaum hloov mus rau Lantus, qhov ntau thiab kev hloov ntawm cov tshuaj tau hloov pauv. Kev hloov pauv cov kua dej yuav tsum tau nqa tawm hauv tsev kho mob nkaus xwb.

Hauv tebchaws Lavxias, txhua tus mob ntshav qab zib insulin-tau raug tshem tawm ntawm Lantus mus rau Tujeo. Raws li kev tshawb nrhiav, cov tshuaj tshiab muaj qhov txo qis ntawm kev noj qab haus huv hypoglycemia, tab sis hauv kev coj ua, cov neeg feem ntau yws tias tom qab hloov mus rau Tujeo lawv cov piam thaj tau dhia heev, yog li lawv raug yuam yuav Lantus Solostar insulin ntawm lawv tus kheej.

Levemir yog cov tshuaj zoo heev, tab sis nws muaj cov tshuaj sib txawv, txawm tias lub sijhawm ua haujlwm kuj yog 24 teev.

Aylar tsis ntsib insulin, cov lus qhia hais tias qhov no yog tib qho Lantus, tab sis cov chaw tsim khoom pheej pheej yig dua.

Insulin Lantus thaum cev xeeb tub

Cov kev tshawb fawb soj ntsuam ntawm Lantus nrog cov poj niam cev xeeb tub tsis tau ua. Raws li cov ntaub ntawv tsis raug cai, cov tshuaj tsis cuam tshuam loj heev hauv chav kawm ntawm cev xeeb tub thiab tus menyuam nws tus kheej.

Cov kev sim tau nrhiav rau ntawm cov tsiaj, thaum lub sijhawm nws tau ua pov thawj tias insulin glargine tsis muaj qhov phiv rau ntawm kev ua me nyuam.

Cev xeeb tub Lantus Solostar tuaj yeem siv tshuaj yog tias tsis muaj zog tiv thaiv NPH. Cov niam yav tom ntej yuav tsum saib xyuas lawv cov suab thaj, vim tias nyob rau thawj peb lub hlis, xav tau cov tshuaj insulin tuaj yeem txo qis, thiab hauv lub hlis thib ob thiab peb lub hlis.

Tsis txhob ntshai tsam pub niam mis rau tus menyuam noj, cov lus qhia tsis muaj cov ntaub ntawv uas Lantus tuaj yeem nkag mus rau niam mis tau.

Khaws cia li cas

Daim ntawv tso cai rau lub sijhawm Lantus yog 3 xyoos. Koj yuav tsum muab cia rau hauv qhov chaw tsaus tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 txog 8 degrees. Feem ntau qhov chaw zoo tshaj plaws yog tub yees. Hauv qhov no, nco ntsoov saib cov txheej txheem kub, vim tias qhov txias khov ntawm cov tshuaj insulin Lantus yog txwv!

Txij li thaum siv thawj zaug, cov tshuaj yuav khaws cia rau ib hlis nyob rau hauv qhov chaw tsaus ntawm qhov kub ntawm tsis ntau tshaj 25 degrees (tsis nyob hauv tub yees). Tsis txhob siv cov tshuaj insulin uas tas sijhawm.

Qhov twg yuav, nqe

Lantus Solostar yog tshuaj dawb los ntawm kev kho mob los ntawm kev kho mob endocrinologist. Tab sis nws tseem tshwm sim uas tus mob ntshav qab zib yuav tsum yuav cov tshuaj no ntawm nws tus kheej ntawm lub tsev muag tshuaj. Tus nqi nruab nrab ntawm cov tshuaj insulin yog 3300 rubles. Hauv Ukraine, Lantus tuaj yeem yuav rau 1200 UAH.

Lantus yog cov noob neej insulin ntev ntev.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Lantus tsim tawm los ntawm kev daws teeb meem rau kev tswj hwm subcutaneous: pob tshab, yuav luag tsis muaj xim lossis xim tsis muaj xim (3 ml txhua xim tsis muaj xim nyob rau hauv daim iav, 5 daim cartridges hauv cov hlwv pob, 1 ntim rau hauv pob ntawv cardboard, 5 OptiClick lub thawv hauv cov thawv sib dhos, 5 txhua OptiSet syringe mem hauv kab ntawv thawv).

Cov tshuaj muaj pes tsawg leeg 1 ml ntawm cov tshuaj muaj xws li:

Cov tshuaj nquag: insulin glargine - 3.6378 mg (sib raug rau cov ntsiab lus ntawm tib neeg cov insulin - 100 PIECES),
Ntu cov khoom siv: zinc chloride, metacresol (m-cresol), 85% glycerol, sodium hydroxide, hydrochloric acid, dej rau kev txhaj tshuaj.

Kev ntsuas rau siv

Cov neeg laus thiab menyuam yaus txij li 2 xyoos muaj mob ntshav qab zib hom 1.
Hom 2 mob ntshav qab zib mellitus (nyob rau hauv cov ntaub ntawv tsis muaj txiaj ntsig ntawm cov ntsiav tshuaj).

Hauv kev rog, kev sib koom ua ke yuav kho tau zoo - Lantus Solostar thiab Metformin.

Kev cuam tshuam nrog lwm yam tshuaj

Muaj cov tshuaj uas cuam tshuam rau cov metabolism hauv cov metabolism, thaum nce los yog txo qis yuav tsum muaj cov insulin.

Txo cov piam thaj: cov tshuaj tiv thaiv kab mob hauv lub cev, sulfonamides, ACE inhibitors, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Qab zib kom ntau: cov thyroid hormones, diuretics, sympathomimetics, tshuaj tiv thaiv qhov ncauj, phenothiazine derivatives, protease inhibitors.

Qee yam tshuaj muaj ob qho ua kom tsis pom kev thiab qhov ua tsis zoo. Cov no suav nrog:

beta blockers thiab ntsev lithium,
cawv
clonidine (antihypertensive tshuaj).

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Lantus thiab lub sijhawm ntawm hnub rau nws cov kev tswj hwm tau teeb tsa ua ib leeg zuj zus.

Cov tshuaj yuav tsum tau muab tshuaj subcutaneously (hauv roj subcutaneous ntawm lub xub pwg, plab los yog ncej puab) 1 ib zaug hauv ib hnub ib txwm tib lub sijhawm. Cov chaw txhaj tshuaj yuav tsum tau hloov nrog txhua tus tswj hwm Lantus tshiab hauv thaj chaw pom zoo rau kev tswj hwm.

Tej zaum siv cov Lantus ua cov tshuaj monotherapy lossis ib txhij nrog lwm cov tshuaj hypoglycemic.

Thaum hloov cov neeg mob nrog nruab nrab ntev lossis ntev ntev los ua cov insulins rau Lantus, nws yuav tsim nyog hloov pauv cov tshuaj tiv thaiv kab mob tiv thaiv kab mob (tshuaj ntawm qhov ncauj hypoglycemic, nrog rau kev tswj hwm kev noj tshuaj thiab kev noj tshuaj insulins luv luv lossis lawv cov analogues) lossis los kho cov tshuaj txhua hnub ntawm cov tshuaj insal basal.

Thaum hloov cov neeg mob los ntawm kev tswj hwm ob npaug ntawm insulin-isofan rau kev tswj hwm ntawm Lantus hauv thawj lub lim tiam ntawm kev kho mob, nws yog ib qho tsim nyog yuav tau txo cov tshuaj txhua hnub ntawm cov tshuaj insal nyob rau 20-30% (txhawm rau txo qhov kev pheej hmoo ntawm hypoglycemia nyob hauv qhov tsaus ntuj thiab sawv ntxov ntxov). Rau lub sijhawm no, qhov txo qis ntawm lub koob ntawm Lantus yuav tsum tau them nyiaj rau los ntawm kev nce ntxiv ntawm cov koob tshuaj tiv thaiv luv luv ntawm kev ua haujlwm thiab kev noj tshuaj rau lub cev yuav tsum tau kho ntxiv.

Thaum lub sijhawm hloov mus rau Lantus thiab hauv thawj lub lis piam tom qab no, yuav tsum tau saib xyuas cov piam thaj hauv cov ntshav yog qhov tsim nyog. Yog tias tsim nyog, kho qhov tsuas tshuaj ntau dua ntawm cov tshuaj insulin. Kev hloov kho koob tshuaj kuj tseem xav tau rau lwm qhov laj thawj, piv txwv li, thaum hloov tus neeg mob txoj kev ua neej thiab lub cev qhov hnyav, lub sijhawm hnub ntawm kev tswj hwm tshuaj, los yog lwm qhov xwm txheej uas ua rau muaj kev cuam tshuam rau kev loj hlob ntawm hyper- lossis ntshav qab zib tsawg.

Cov tshuaj yuav tsum tsis txhob muab tshuaj rau qhov ntswg (mob ntshav qab zib tsawg heev yuav ua mob hnyav). Ua ntej pib cov lus qhia, koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj qhov seem ntawm lwm cov tshuaj.

Ua ntej siv OptiSet ua ntej puv syringe cwjmem, koj yuav tsum paub tseeb tias cov kev daws teeb meem tsis muaj xim, pob tshab, zoo li cov dej hauv kev ntxhib los mos thiab tsis muaj cov khoom pom. Tsuas yog cov koob txhaj rau OptiSet koob txhaj tshuaj siv tau. Txhawm rau tiv thaiv kev kis mob, tsuas yog ib tus neeg yuav tsum siv koob txhaj tshuaj ntxiv.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tiv thaiv kab mob rau hauv lub cev, fluoxetine, angiotensin-hloov enzyme inhibitors, fibrates, disopyramide, dextropropoxyphene, pentoxifylline, salicylates thiab sulfanilamide antimicrobials tej zaum yuav tsum tau ntxiv cov tshuaj tiv thaiv hypoglycemia thiab insulin hypoglycemic, thiab antimicrob yuav tsum tau.

Cov thyroid hormones, diuretics, glucocorticosteroids, diazoxide, danazole, isoniazid, qee cov tshuaj tiv thaiv kab mob (xws li clozapine lossis olanzapine), glucagon, progestogens, estrogens, somatotropin, phenothiazine derivatives, sympathomoltamines (piv txwv li, sympathomoltamines) tuaj yeem txo qis. , protease inhibitors (hauv qhov no, yuav tsum tau txhaj tshuaj insulin).

Siv cov tshuaj insulin nrog pentamidine tib lub sijhawm tuaj yeem ua rau lub qog ntshav qab zib, uas tuaj yeem hloov los ntawm hyperglycemia. Nrog tib lub sijhawm siv Lantus nrog clonidine, beta-blockers, ethanol thiab lithium ntsev, ob qho tib si nce thiab txo qis hauv cov nyhuv hypoglycemic ntawm insulin yog ua tau.

Nrog tib lub sijhawm siv Lantus nrog cov tshuaj sympatholytic (clonidine, beta-blockers, guanfacin thiab reserpine) nrog kev txhim kho ntawm hypoglycemia, qhov txo qis lossis tsis muaj cov cim ntawm adrenergic counterregulation yog ua tau.

Daim roj pleev kab yuav tsum tsis txhob sib xyaw lossis yaj nrog lwm cov tshuaj insulin lossis nrog lwm yam tshuaj. Thaum diluted los yog sib xyaw, qhov profile ntawm nws qhov kev txiav txim hauv lub sijhawm yuav hloov. Nws tseem tuaj yeem ua rau cov nag lossis daus.

Cov lus thiab cov xwm txheej ntawm kev cia

Muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus ntawm qhov kub ntawm 2-8 ° C, tsis txhob khov.

Txee lub neej yog 3 xyoos.

Tom qab pib siv cov khoom siv cartridges, OptiClick cartridge system thiab OptiSet pre-filled syringe pens yuav tsum tau muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam, ntawm qhov kub txog 25 ° C hauv lawv tus kheej lub thawv ntawv ntim.

Ua ntej OptiSet koob txhaj tshuaj tsis tas yuav tsum tau cia kom txias.

Daim ntawv tshaj tawm hnub tim tag nrho nyob rau hauv daim cartridges, OptiClick cartridge system thiab ua ntej OptiSet syringe pens tom qab siv thawj zaug - 1 hlis.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

Qhov khi khi txuas rau cov tshuaj insulin rau ntawm insulin glargine thiab insulin tib neeg yog qhov zoo heev. Glulin insulin muaj cov roj ntsha zoo ib yam li cov insulin endogenous.

Lub sijhawm ntawm cov tshuaj Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous.

Insulin glargine + excipients.

Nrog s / c tswj hwm ntawm cov tshuaj 1 zaug hauv ib hnub, qhov nruab nrab ruaj khov ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug.

Nrog kev tswj hwm intravenous, ib nrab-lub neej ntawm insulin glargine thiab tib neeg insulin yog qhov sib piv.

mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj 6 xyoo,
mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj li 2 xyoos (rau SoloStar daim ntawv).