Liraglutide thiab kev rog dhau - vim li cas cov tshuaj uas haum rau kev kho mob ntawm pathology?

Cov tshuaj muaj nyob hauv qab cov npe lag luam Viktoza thiab Saksenda. Nws yog cov lus meej thiab tsis muaj kev daws teeb meem rau kev tswj hwm ntawm subcutaneous. Cov kua yog muag hauv iav daim cartridges, kaw rau hauv cov yas ntim ntau cov tshuaj tiv thaiv ib zaug rau kev txhaj tshuaj thiab muab tso rau hauv cov thawv ntim khoom.

Saxenda thiab Viktoza muaj cov khoom sib xws. Cov tshuaj ua kom nquag plias yog liraglutide, thiab cov khoom siv ntxiv yog sodium hydrogen phosphate dihydrate, hydrochloric acid / sodium hydroxide, phenol, dej rau txhaj, propylene glycol.

Pharmacological kev txiav txim

Cov tshuaj nquag siv ntawm cov tshuaj yog cov ntawv luam tawm ntawm tib neeg glucagon-zoo li peptide-1. Cov synthetically tsim GLP-1 yog xyaum sib cais ntawm qhov qub (qhov ntsuas ntawm qhov zoo sib xws yog 97%), yog li lub cev tsis pom qhov sib txawv ntawm lawv. Nrog kev tswj hwm subcutaneous, liraglutide khi rau cov txais, ua kom cov khoom ntawm glucagon thiab insulin tsim khoom. Sij hawm dhau mus, insulin pib tsim los ntawm nws tus kheej, uas ua rau kev ua haujlwm li qub ntawm ntshav qab zib.

Cov txheej txheem ntawm kev txiav txim ntawm ib yam khoom tuaj yeem piav qhia raws li hauv qab no:

1. Tus naj npawb ntawm peptides yog nce.
2. Kev ua haujlwm ntawm tus txiav ua tiav, cov ntshav qab zib cov ntshav yuav poob rau li qub.
3. Cov as-ham uas nkag mus rau hauv lub cev los ntawm cov khoom noj yog nqus tau puv.
4. Lub teeb liab ntawm kev saturation nkag hauv lub hlwb.
5. Qab los tsawg zuj zus, lub cev poob tuaj.

Kev ntsuas rau siv

Cov tshuaj yog tawm rau cov neeg laus cov neeg mob ntshav qab zib hom 2 ntshav qab zib kom rov qab muaj glycemic index thiab poob ceeb thawj. Lawv tuaj yeem siv los ua tus neeg sawv cev ywj siab thiab ua ib feem ntawm kev sib xyaw ua ke (nrog metformin, insulin, thiazolidinediones, sulfonylurea derivatives).

Yog tias tus neeg mob ntshav qab zib muaj kab mob plawv, liraglutide yog siv ua ib feem ntawm txoj kev kho mob kom txo tau txoj kev pheej hmoo ntawm mob stroke, myocardial infarction, thiab tuag.

Cov lus qhia rau kev siv tshuaj

Txhawm rau kho kev rog, Saksenda siv - ib qho kev daws teeb meem rau kev coj noj coj ua subcutaneous. Cov tshuaj raug muag nyob rau hauv daim ntawv ntawm rab koob txhaj tshuaj nrog qhov ntsuas kom txiav txim siab qhov xav tau ntau npaum li cas. Koj tuaj yeem txhaj tshuaj rau thaum sawv ntxov, yav tav su lossis yav tsaus ntuj, tsis hais txog ntawm cov pluas noj. Cov kws kho mob pom zoo kom tswj cov tshuaj thaum tib lub sijhawm ntawm hnub kom ntseeg tau sib npaug sib luag ntawm kev txhaj tshuaj.

Qhov kev txiav txim ntawm kev tswj hwm tshuaj yog raws li nram no:

1. Cov koob txhaj tshuaj tau tso rau hauv qab daim tawv nqaij raws li cov lus pom zoo los ntawm tus kws tu neeg mob lossis kws kho mob. Cov koob txhaj tshuaj yog qhov tuav kom lub koob tshuaj yuav tau pom.
2. Lub khawm pib pib nias txhua txoj kev thiab tuav kom txog thaum tus lej 0 tshwm nyob rau hauv pem hauv ntej ntawm lub koob taw qhia.
3. Tuav lub rab koob nyob hauv qab ntawm daim tawv nqaij thiab maj mam suav rau 6.
4. Tshem tawm rab koob. Thaum cov ntshav pom tshwm, daim ntaub qhwv lub paj rwb huv rau hauv qhov chaw txhaj tshuaj.

Cov tshuaj yuav tsum tau muab rau 1 zaug ib hnub hauv lub xub pwg, ncej puab lossis plab. Cov koob tshuaj txhua hnub nyob ntawm lub sijhawm ntawm kev siv tshuaj:

• 1 lub lim tiam - 0.6 mg
• 2 lub lis piam - 1.2 mg,
• 3 lub lis piam - 1.8 mg,
• 4 lub lis piam - 2.4 mg,
• 5 lub lis piam thiab tom qab - 3 mg.

Qhia ntau dua 3 mg ntawm cov tshuaj ib hnub yog txwv tsis pub, vim tias qhov no tuaj yeem ua rau kev txhim kho ntau tshaj.

Yuav ua li cas ua tau zoo yog liraglutide rau poob phaus?

Kev hno cov tshuaj liraglutide qeeb qeeb ua rau cov txheej txheem ntawm kev zom zaub mov, uas ua rau txo qis qab los noj mov thiab txo qis hauv lub sijhawm ua kom muaj caloric tsawg ntawm kev noj haus los ntawm 15-20%. Qhov no piav qhia txog qhov ua tau zoo ntawm cov tshuaj yeeb tshuaj thiab cov ntau ntawm kev tshuaj xyuas zoo txog nws.

Rau qhov kev poob ceeb thawj zoo, kev txhaj tshuaj ib leeg tsis txaus. Cov kws qhia noj haus pom zoo kom siv cov tshuaj ua kom sib xyaw nrog lwm txoj hau kev thiab cov txheej txheem ntawm kom poob phaus. Cov lus pom zoo hauv qab no yuav pab ua kom qhov txheej txheem ceev:

1. Cov khoom noj kom zoo. Yuav kom txo qhov hnyav, nws yog qhov yuav tsum tau ua kom txo tau cov calories kom txhua hnub. Ua li no, tso cov hmoov nplej thiab cov khoom tsis sib xws, roj thiab kib zaub mov. Qee cov kws qhia kev noj haus pom zoo kom noj zaub mov me 5 mus rau 6 zaug hauv ib hnub, tab sis endocrinologists hais tias kev noj zaub mov zoo li no tuaj yeem tsim kev txhim kho ntawm insulin tsis kam.
2. Lub cev qoj ib ce. Taug kev hauv cov huab cua huv, dhia dhia qoj ib ce, dhia ua si hauv chav ntaus pob, ua luam dej thiab lwm yam kev tawm dag zog yuav pab ua kom muaj calories ntau.
3. Ua raws li cov tshuaj uas koj tus kws kho mob pom zoo. Qhov kev daws teeb meem yuav tsum tau siv ntawm 3 mg ib hnub twg (tshwj tsis yog thawj 4 lub lis piam, thaum muaj tshuaj ntaug zuj zus lawm).

Ntau dua 80% ntawm cov neeg siv liraglutide rau qhov hnyav poob muaj qhov zoo. Qhov seem 20% ntawm cov kev hloov pauv tsis pom.

Yeeb tshuaj sib cuam tshuam

Thaum kho, kho lub plab zom mov yog ib qho kev ncua, uas cuam tshuam rau qhov teeb meem ntawm kev nqus ntawm lwm yam tshuaj. Xws li kev sib cuam tshuam tsis zoo, yog li hloov chaw ntau npaum ntawm cov tshuaj tsis tsim nyog.

Kev sib tov nrog lwm cov tshuaj yog txwv tsis pub, vim tias qhov no yog fraught nrog kev puas tsuaj ntawm cov nquag ua haujlwm ntawm cov tshuaj.

Liraglutide tuaj yeem siv ib txhij nrog thiazolidinedione thiab metformin ua ib feem ntawm txoj kev kho kom ncaj.

Cov Yuav Tsum Tau Ua

Cov kev ua txhaum rau kev siv cov tshuaj tau muab faib ua qhov tseeb thiab qhov sib txheeb. Nws yog nruj me ntsis txwv tsis pub txhaj tshuaj nyob ib puag ncig cov kab mob thiab kab mob:

• tus kheej tsis kam rau lub nquag thiab ntxiv ntawm cov kev daws teeb meem,
• ntshav qab zib hom 1
• lub plawv tsis ua haujlwm (hom 3 thiab 4),
• lub qog mob cancer
• kev tsis taus los ntawm lub raum lossis hepatic muaj nuj nqi,
• ntau yam kab mob endocrine neoplasia,
• inflammatory plob tsis so tswj pathologies,
• lub sijhawm pub niam mis, cev xeeb tub.

• pancreatitis (kev nyab xeeb ntawm cov tshuaj hauv cov neeg mob uas kuaj pom tsis tau tshawb nrhiav),
• hnub nyoog laus (tshaj 75 xyoo),
• tib lub sij hawm siv cov tshuaj insulin thiab lwm yam agonists ntawm GLP-1,
• kev mob plawv
• kev siv lwm cov ntsiav tshuaj thiab cov kev daws rau kom poob phaus.

Nws kuj tseem tsis pom zoo kom muab kev txhaj tshuaj rau menyuam yaus thiab thaum tiav hluas, vim tias lub cev tiv thaiv cov tshuaj txhaj tuaj yeem tsis tuaj yeem pom. Tsuas yog tus kws kho mob tuaj yeem sau tshuaj rau cov neeg mob hnub nyoog qis dua 18 xyoo, nco ntsoov tias muaj kev qhia thiab tsis muaj kev sib kis.

Sab sij huam

Feem ntau, cov neeg mob uas siv liraglutide muaj qhov tsis txaus siab txoj hnyuv tawm:

• hauv 40% ntawm cov neeg mob - xeev siab (qee zaus nrog kev ntuav),
• hauv 5% ntawm cov neeg mob - tso quav muaj quav (cem quav, raws plab).

Kev saib xyuas tshwj xeeb yuav tsum tau ua rau cov neeg muaj ntshav qab zib hom 2. Hauv 3 ntawm 100 tus neeg mob, kev kho lub sijhawm ntev nrog cov kab mob liraglutide ua rau kev txhim kho hypoglycemia.

Lwm yam kev phiv uas tshwm sim thaum kho nrog cov tshuaj tiv thaiv cov hauv qab no:

• mob taub hau
• kev siv roj ntxiv,
• tsis muaj zog, qaug zog,
• kev fab tshuaj tsis haum (suav nrog ib ncig thaj chaw txhaj tshuaj),
• cov kab mob sib kis ntawm lub nruab pa ceev,
• nce lub plawv dhia - lub plawv dhia.

Feem ntau cov kev mob tshwm sim tau pom hauv 7-14 hnub txij li hnub pib kho. Sij hawm dhau mus, lub cev tau siv cov tshuaj, thiab qhov kev xav tsis haum dhau los ua qhov tsawg dua. Yog tias cov xwm txheej saum toj no tsis dhau ntawm lawv tus kheej lossis ua ntau ntxiv, koj yuav tsum sab laj nrog kws kho mob.

Tus nqi tshuaj

Tus nqi ntawm liraglutide hauv khw muag tshuaj yog nyob ntawm lub npe kev lag luam thiab cov ntsiab lus ntawm cov nquag:

• Cov neeg raug, 6 mg / ml, 3 ml, 2 pcs. - txij 9500 rub.,
• Victoza, 18 mg / 3 ml, 2 pcs. - txij 9000 rub.,
• Saxenda, 6 mg / ml, 3 ml, 5 pcs. - txij 27000 rub.

Yog tias siv cov tshuaj Saxend thiab Viktoz siv tsis tau, koj yuav tsum sab laj tus kws kho mob kom xaiv cov tshuaj uas muaj cov nyhuv zoo sib xws. Ib qho ntawm cov kev hais hauv qab no tuaj yeem dhau los ua cov tshuaj:

1. Novonorm (ntsiav tshuaj). Nws yog tshuaj rau cov neeg mob ntshav qab zib hom 2. Siv los maj mam txo cov ntshav piam thaj. Nws yog cov tshuaj analogue pheej yig tshaj (ntim raug nqi 150-250 rubles).
2. Liksumiya (kev daws rau sc coj). Txo cov ntshav qab zib tsis hais lub sijhawm noj mov npaum li cas. Nws raug nqi 2500-7000 rubles.
3. Forsiga (ntsiav tshuaj). Pab pab ua kom cov piam thaj kom qis thiab cov ntshav qab zib tsawg dua tom qab noj mov. Tus nqi ntawm 1 rab koob yog 1800-2800 rubles.
4. Byeta. Tus sawv cev ntawm cov amino acid amidopeptides. Kev ua haujlwm qeeb hauv lub plab zom mov, txhawb kev qab los noj mov, pib txoj kev poob. Nws yog qhov kim tshaj plaws analogue (1 koob txhaj tshuaj kwv yees li 10,000 rubles.).

Tsuas yog kws kho mob tuaj yeem sau tshuaj kom zoo sib xws xwb. Qhov kev xaiv ywj siab ntawm hypoglycemic tus neeg sawv cev yog fraught nrog qhov tsis muaj ntawm kev kho mob thiab kev txhim kho ntawm qhov tsis xav tau los ntawm kev mob plab thiab lwm yam hauv lub cev.

Inga, 45 xyoos, Moscow: “Kuv nrhiav tau tus mob ntshav qab zib mellitus 5 xyoos dhau los. Kuv tsis tau pom dua nyias, tab sis nyob rau xyoo tas los no, lub cev hnyav tau dhau los ua qhov tseem ceeb. Kuv tau sim kom poob ceeb thawj los ntawm kev ua kis las thiab kev noj zaub mov kom zoo, tab sis ua tsis tiav. Tus kws kho mob qhia kom yuav cov tshuaj Saksenda ua kev tov tshuaj thiab qhia tias yuav ua li cas thiaj li txhaj tshuaj kom yog. Thaum xub thawj nws txaus ntshai thiab tsis xis, tab sis thaum kawg tau siv rau nws. Thaum kho, Kuv tswj kom poob 4 kg, Tam sim no kuv yuag yuag. ”

Lub nroog Kirill, 51 xyoo, St.““ Kuv yuag tsis poob mus txog thaum kuv mus ntsib ib tug kws qhia noj zaub mov. Kuv tsis pom muaj ib qho kev txhaum dab tsi rau kev siv Liraglutide, yog li tus kws kho mob tau qhia kuv kom muab tshuaj tiv thaiv. Thaum kawg ntawm txoj kev kawm, nws tau pib coj tshuaj diuretics los sib sau ua ke cov txiaj ntsig. Lub cev hnyav tseem tsis rov qab los. "

Larisa, hnub nyoog 42 xyoos, Samara: “Kuv tau sim nrhiav ntau cov pluas noj kom yuag, tab sis lawv tsis pab. Kuv txiav txim siab los yog qhov kev kho tshuaj thiab tig mus rau endocrinologist, tus kws kho mob kom txhaj tshuaj Saksenda. Rau ob peb lub hlis nws muaj peev xwm ua kom poob 5 kg, tab sis cov txheej txheem ntawm kev ua kom poob ceeb thawj los txog rau hnub no. Kuv xav ceeb toom rau cov neeg uas yuav noj cov tshuaj no: tsis muaj dab tsi tuaj yeem ua haujlwm tsis muaj kis las thiab noj zaub mov kom raug, yog li sim ua lub neej noj qab haus huv thaum lub sijhawm thiab tom qab kho. "

Kev taw qhia thiab ua tau zoo

Cov tshuaj raug xa mus rau hauv cov tshuaj xws li liraglutide yog ib qho khoom sib piv ntawm cov tshuaj hormones hluavtaws los ntawm cov hnyuv hlwb - glucagon-zoo li peptide-1 (GLP-1). Ua tsaug rau txoj kev txhim kho rau tom kawg, ib qho kev tiv thaiv kom zoo dua yog tsim, uas zam kev dhau los nrog lub cev nce ntxiv tom qab. Hauv lwm lo lus, GLP-1 yog lub zog tswj kev ua kom qab los noj mov thiab zaub mov noj.

Ntau dhau liraglutide siv nyob rau hauv daim ntawv ntawm Saxenda thiab Victoza npaj. Lub tuam txhab Novo Nordisk (Denmark) koom nrog lawv ntau lawm. Cov tshuaj muaj tshuaj nyob rau hauv daim ntawv ntawm tus cwj mem-kua muag puv nrog kev daws teeb meem uas tau npaj rau kev tswj hwm hauv subcutaneous.

Kev xyaum qhia tau hais tias nrog kev siv tshuaj kom raug cai liraglutide, nws muaj peev xwm ua tiav qhov txo qhov hnyav hauv lub cev.

Lawv tau xaj rau cov neeg mob nrog:

• ntshav qab zib hom 2, uas nrog cov rog,
• BMI saum toj 30 tsis muaj kab mob sib kis,
• BMI ntawm 27, thaum lwm cov kab mob pathological tshwm sim thaum nce phaus (piv txwv li ntshav siab lossis roj cholesterol nce),
• apnea, uas cuam tshuam nrog cov tsos ntawm cov phaus ntxiv,
• glycemic Performance index kev ntshawv siab.

Soj ntsuam cov nyhuv thiab cov khoom

Ua cov ntawv luam tawm ntawm tib neeg glucagon-zoo li peptide-1 (97%), liraglutide pab tswj kev tsim cov tshuaj insulin, uas tom qab ua rau ntshav ntshav qabzib. Cov tshuaj muaj cov nyhuv ntev ntev, uas, tshwj xeeb, qhov kev rau txim ntawm nws theem siab ntawm enzymatic ruaj khov.

Vim muaj liraglutide, ntau cov txheej txheem tseem ceeb tshwm sim:

• pancreatic beta hlwb uas koom nrog hauv insulin ntau lawm txhim kho
• ntev li ntawm glucagon tso tawm yog inhibited.

Yog tias cov piam thaj hauv ntshav nce siab, cov roj ntsha liraglutide ua rau cov kua dej hauv cov ntshav ua rau lub cev tsis txaus thiab tiv thaiv cov khoom ntawm glucagon. Nrog hypoglycemia, cov nyhuv ntawm cov khoom sib txuas ntawm GLP-1 yog tsom rau txo kev tso tawm ntawm insulin.

Kev tshem tawm cov rog mus ntau ntau thaum noj liraglutide yog nqa tawm los ntawm kev txo kev tshaib plab thiab xa cov teeb liab mus rau lub hlwb hais txog kev saturation ceev, thaum lub cev nkag siab cov khoom noj uas tuaj nrog zaub mov.

Cov nyhuv ntawm liraglutide ntawm lub cev

Liraglutide yog glucagon-zoo li peptide-1 (GLP-1) synthesized artificially. Daim ntawv 97% sib raug rau lub ntuj tsim hauv qhov qauv.

Kev ua nyob rau hauv lub cev tom qab ua haujlwm:

• lowers qab zib
• txhawb kev tsim peptides, glucagon thiab insulin,
• ua rau kom cov assimilation ntawm cov as-ham rau tag nrho,
• lub hlwb tau txais lub teeb nrawm nrawm,
• qab los noj mov raug txo kom tsawg.

Ua tsaug rau qhov qhia txog ntawm loraglutide, lub ntuj tig ntawm kev tsim tawm insulin yog ib txwm muaj. Lub luag haujlwm ntawm tus txiav ua rov qab, lub ntsej muag metabolic tsawg dua, thiab lub siab poob qis.

Lub ntsiab contraindications

Qhov no hypoglycemic tus neeg sawv cev yog paub tsis yog rau nws lub peev xwm los tshem tawm cov rog ntau. Muaj ntau tus lej sib kis uas yuav tsum tau txiav txim siab ua ntej pib kho.

Lawv teev npe:

• ntshav qab zib hom 1
• mob raum thiab mob rau daim siab,
• lub plawv tsis ua haujlwm 3-4 hom,
• inflammatory plob tsis so tswj pathologies,
• mob ketoacidosis,
• paresis ntawm lub plab
• cov qog hlav hlav,
• ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Liraglutide yog txwv tsis pub siv mus txog 18 xyoo thiab tom qab 75, nrog rau lub sijhawm cev xeeb tub thiab thaum pub niam mis.

Sab sij huam

Feem ntau, kev txhaj tshuaj ntawm cov tshuaj ua rau muaj qhov tsis txaus siab los ntawm txoj hnyuv. Cov neeg mob tau hnov ​​mob tsis xeev siab, ntuav, tso quav tawm, uas feem ntau ua rau tsis kam siv Liraglutida.

Daim ntawv teev cov kev mob tshwm sim yuav tsum tau ntxiv ntxiv:

• mob gallstone
• pancreatitis
• tachycardia
• sab sauv ntawm txoj hlab ua pa tuaj
• mob taub hau
• qaug zog,
• kev fab tshuaj tiv thaiv.

Raws li kws kho mob, cov tsos mob tsis zoo yog nyob rau thawj 2 lub lis piam tom qab pib kho, tom qab ntawd nws maj mam muaj zog thiab ploj mus.

Qhov ua tau zoo ntawm liraglutide rau kom poob phaus

Qhov tshwm sim ntawm qhov poob phaus thaum nkag mus tau raug pom los ntawm 80% ntawm cov neeg mob uas coj Victoza los ntawm ntshav qab zib mellitus. Thaum siv liraglutide, tus nqi ntawm kev yoo ntawm cov zaub mov raug txo kom tsawg. Kev tshaib plab yog thaiv, qab los noj mov yog qhov ib txwm muaj thiab cov zaub mov noj tau tsawg dua. Kev pab rau kwv yees li 20% me dua.

Txhawm rau kom paub tseeb tias Viktoza muaj txiaj ntsig zoo rau qhov poob phaus, cov nyhuv ntawm cov tshuaj tau sim hauv kev coj ua. Qhov kev sim koom nrog 564 cov neeg tuaj yeem pab dawb. Cov neeg mob tau muab faib ua 3 pab. Txhua tus tau ua raws kev noj zaub mov kom muaj calorie tsawg thiab kawm txhua hnub. Hloov ntawm Victoza, thawj pab pawg tau txhaj tshuaj nrog cov placebo. Xenical, ib qho tshuaj poob phaus nrog cov rog rog, tau muab tso rau cov neeg pab dawb hauv pab pawg thib ob. Cov neeg mob ntawm pab pawg thib peb nyob rau hauv tib co mob tau ua Viktoza txhaj tshuaj.

Lawv tau sim ua pov thawj tias cov txiaj ntsig zoo tshaj plaws tau los ntawm cov neeg pab dawb ntawm pawg peb. Tus naj npawb ntawm cov neeg uas poob ceeb thawj yog 75% piv nrog 30% thiab 45% ntawm cov pab pawg ntxiv.

Tsis tas li ntawd, nws muaj peev xwm tsim tau hais tias rau qhov poob phaus ruaj khov, cov tshuaj muab tshuaj yuav tsum yog tsawg kawg 3 mg rau cov tshuaj nquag.

Lawv kuj pom tias yuav kom poob phaus, tsuas yog noj tshuaj tsis txaus. Cov kev ntsuas nyuaj pab txo kev hnyav: kev noj zaub mov kom lub cev tsis muaj zog, ua kom lub cev thiab siv Victoza.Nws raug nquahu thaum siv cov tshuaj kom thim tawm kev haus luam yeeb thiab haus dej haus cawv.

Daim ntawv tso tawm khoom tawm

Tsis muaj cov tshuaj noj cov tshuaj nrog cov tshuaj loraglutide, cov tshuaj muaj nyob rau hauv hom kev txhaj tshuaj. Hauv txoj hauv kev hnyav kom poob ceeb thawj, cov tshuaj tau muab tshuaj subcutaneously.

Lawv yuav cov tshuaj nyob rau hauv cov koob txhaj tshuaj uas zoo xws li cov tshuaj insulin. Txhua tus koob txhaj tshuaj muaj qhov ntsuas nrog kev sib cais, vim qhov uas tau muab tshuaj rau. Ib qho kev daws teeb meem los ntawm ib qho koob txhaj tshuaj yog txaus rau 10-30 hno. Koj tuaj yeem tso tshuaj subcutaneous kev txhaj tshuaj rau koj tus kheej, vim nws yooj yim dua: hauv tus ncej puab, plab lossis hauv xub pwg.

Ua ib feem ntawm cov khoom slimming:

• liraglutide - nquag ua ub ua no, nyob rau hauv 6 mg,
• propylene glycol - 14 mg,
• sodium hydrogen phosphate dihydrate - 1.42 mg,
• phenol - 5.5 mg
• sodium hydroxide - txog li 1 ml,
• hydrochloric acid - 1 ml,
• dej rau kev txhaj tshuaj.

Ob qho kev kho mob no muaj nyob rau hauv cov khw muag tshuaj. Victoza tuaj yeem muas tau 9000-10000 rubles:

• Ib qho kev daws teeb meem rau kev tswj hwm hauv subpaneous hauv ampoules, 6 mg / ml,
• Tus xaum xaum hauv lub thawv rau hauv tib lub tshuaj,
• Cov xaum xaum xim tsis muaj daim cartridge - 18 mg / 3 ml.

Saxenda nqi tsawg kawg 27,000 rubles. Hauv ib pob ntawm 5 koob txhaj nrog daim cartridge ntawm 3 ml, kuj 6 mg / ml. Saxenda, uas yog muag hauv Russia, kuj tseem tsim los ntawm lub tuam txhab Danish.

Qhov sib txawv ntawm Saksenda thiab Viktoza

1. Saxenda nrog liraglutide tau tsim rau qhov hnyav dua. Victoza tau tsim tawm thaum xub thawj los txo qis ntshav qab zib kom tsawg.
2. Muaj yeeb tshuaj ntau dua hauv Saxend cwj mem-koob txhaj ntau dua li hauv cov koob txhaj nrog Viktoza.
3. Thaum siv Saxenda rau kev poob phaus, cov kev mob tshwm sim tsawg dua.

Cov lus qhia rau kev siv nrog liraglutide

Tom qab yuav khoom, ntim khoom sai yog muab tso rau hauv tub yees, ntawm txee. Thaum khov los yog kub tom qab cua sov tshaj + 25 ° C, cov khoom muaj tshuaj tsis tau tshwj tseg. Lub sijhawm siv cia 30 lub hlis txij li hnub tawm.

Cov ntawv thov yog ua tau raws li ib feem ntawm kev kho mob nyuaj thiab ua cov tshuaj cais. Thaum siv, phiv qee zaum tshwm sim.

Cov lus qhia rau kev siv yog txuas rau ob qho tshuaj nrog liraglutide. Nws muaj cov lus pom zoo rau kev tswj hwm. Yog tias tsis muaj cov lus qhia tshwj xeeb, lawv raug tswj hwm raws li cov phiaj xwm hauv qab no, tsis hais txog daim ntawv ntawm kev tso tawm.

Kev suav ntawm kev muab tshuaj yog muab raws li cov khoom nquag.

1. Hauv 7 hnub txij li hnub pib kho, 3 mg ib hnub. Koob tshuaj ib zaug tau muab xam raws qhov xwm txheej ntawm tus neeg mob. Qhov siab tshaj plaws thawj zaug yog 1.8 mg.
2. Los ntawm 2 lub lis piam, ntau npaum li cov tshuaj tau nce 0.6 mg thiab tom qab ntawd ntxiv txhua 7 hnub.
3. Qhov poob qis kuj tau zuj zus, txij li 5 lub lis piam.
4. Txog thaum kawg ntawm chav kawm, qhov koob tshuaj txhua hnub yog dua 3 mg.
5. Yog tias koj plam lub sijhawm txhaj tshuaj vim li cas los xij, koj tuaj yeem nkag mus rau qhov tshuaj yeeb tshuaj nyob hauv 12 teev. Nrog kev ncua sijhawm ntau tshaj li ib nrab ntawm ib hnub, kev txhaj tshuaj ploj lawm.

Kev txhaj tshuaj yog qhov ywj siab ntawm cov zaub mov noj lossis cov txheej txheem ua haujlwm, tab sis nws raug nquahu kom ua nws tib lub sijhawm. Tshaj tawm ntawm kev txhaj tshuaj - 1-3 zaug hauv ib hnub.

Rau kev siv yooj yim, kev pheej hmoo yog siv rau cov koob txhaj tshuaj, coj mus rau qhov sib txuam ntawm 0.6 mg - los ntawm 0.6 txog 3 mg, uas yog, 0.6, 1.2, 2.4, thiab lwm yam. Lub sijhawm ua haujlwm ntawm kev kho thiab ntau npaum li tau txiav txim siab ntawm tus kheej, qhov kawm tsawg kawg yog 4 hli, qhov siab tshaj yog 12 hli.

Nws yog tsis yooj yim sua kom poob ceeb thawj cov kev hno tib yam nrog liraglutide. Qhov hnyav yog txo nrog cov kev ntsuas nyuaj, suav nrog kev noj zaub mov kom lub cev tsawg, ua kom lub cev ua haujlwm thiab noj tshuaj ntxiv uas ua rau cov txheej txheem metabolic nce ntxiv. Cov tshuaj uas txhim kho cov nyhuv ntawm kev txhaj tshuaj yog xaiv los ntawm tus kws kho mob, suav txog qhov kev ntsuas mob anamnesis.

Yuav ua li cas lis cov tes tuav ib leeg

Ua ntej siv thawj zaug:

1. Nco ntsoov kos hnub kos npe tas sij hawm.
2. Txheeb xyuas cov xwm txheej ntawm cov tshuaj. Yog tias qhov kev daws teeb meem yog pos huab lossis nag lossis daus nag lossis daus, qhov kev txhaj tshuaj tau muab pov tseg.
3. Tshem daim nplaum thaiv tawm ntawm rab koob pov tseg.
4. Muab rab koob tso rau ntawm lub taub hau, tso lub hau sab nraud, thiab muab nws tso es nws thiaj li rov siv tau.
5. Lub hau puab yog pov tseg.
6. Nias maj mam tso rau ntawm tus nqus dej ntawm cov xov txhaj kom nyem tawm 1 poob ntawm qhov kev daws teeb meem. Yog hais tias lub piston tsis ua hauj lwm, qhov kev daws teeb meem tsis tawm, cov phwj tawm pov tseg.

Thaum txhaj, daim tawv nqaij tsis chwv nrog cov ntiv tes kom tiv thaiv kev kis mob. Cov tshuaj yog maj mam muab kom cov tshuaj faib kom tsis txhob txav ceev. Tom qab cov koob xav tau nyob hauv qab ntawm daim tawv nqaij, rab koob tsis tau rub tawm tam sim ntawd thiaj li ua rau cov tshuaj tsis xau. Nws raug nquahu kom suav rau 6 thiab xwb ces tshem rab koob. Cov paj rwb qhwv nrawm yog nias rau qhov chaw txhaj tshuaj, daim tawv nqaij tsis yog zaws.

Ua ntej tshem cov koob txhaj nrog cov kev daws rau kev txhaj tshuaj tom ntej, cov koob siv tau muab tso rau hauv lub hau tiv thaiv. Ib rooj plaub yog muab tso rau daim ntawv syringe, uas tiv thaiv kev daws teeb meem los ntawm teeb.

Cov qauv ntawm liraglutide rau qhov poob phaus

Cov tshuaj sib piv ntawm cov tshuaj qub hauv kev nqis tes ua:

1. Novonorm, ntsiav tshuaj, 160 rubles. Qhov kev txiav txim zoo sib xws, tab sis siv tsis yooj yim. Qhov ntau zaus ntawm kev tswj hwm 4 zaug hauv ib hnub nyob rau hauv kev muab vaj huam sib luag ntawm cov sijhawm sib npaug. Qhov hno txhua hnub yog 16 mg, ntsiav tshuaj tau noj ua ntej noj mov.
2. Diaglinid, 200 rubles. Kev txais tos yuav pib nrog ib koob ntawm 0.5 mg, tom qab ntawd maj mam nce thiab nqa mus txog 12 mg hauv 3 koob.
3. Orsoten, 600 rubles. Cov lus pom zoo rau siv - 30 feeb ua ntej noj mov lossis 45-60 feeb tom qab. Muaj nyob rau hauv qhov tsis pom kev capsules, tus nqi ntawm cov tshuaj nquag hauv txhua 12 mg. Haus ib hnub ib zaug.
4. Reduxin, txoj kev kho mob nrov tshaj plaws, 1600 rubles. Lub sijhawm siv ntawm kev kho mob yog los ntawm 3 hlis txog 2 xyoos, koob tshuaj txhua hnub ntawm 10 mg, tso tawm - tsiav tshuaj.
5. Forsyga, tus nqi yog 2400 rubles. Cov lus pom zoo rau kev siv zoo ib yam li Reduxin.
6. Baeta hauv cov xaum npuav. Siv los txo qhov qab los noj mov, txo tus nqi ntawm peristalsis. Tus nqi ntawm 10,000 rubles.
7. Liksumia - 2500-7000 rubles. Lowers ntshav qab zib, tsis hais txog kev ua zaub mov noj.

Ua ntej xaiv cov tshuaj analogue, nws raug nquahu kom sab laj nrog koj tus kws kho mob. Cov kev txuam rau kev siv thiab cov ua rau lub cev ntawm cov ntau npaum ntawm cov tshuaj sib txawv. Kev tsis paub ntaub ntawv siv tsis zoo cuam tshuam kev noj qab haus huv.

Qhov twg ntawm liraglutide zoo dua?

Coob tus neeg mob them tsis taus tshuaj vim tias nws tus nqi kim. Kuj tseem ceeb heev yog cov npe loj ntawm cov kev mob tshwm sim. Hloov chaw txhaj tshuaj liraglutide, koj tuaj yeem siv ntau cov ntsiav tshuaj pheej yig ntawm ntau hom. Qhov loj tshaj plaws yog tias txoj kev kho rau kev rog rog yuav tsum tau xaiv los ntawm tus kws tshaj lij.

Ib qho analogue tseem muaj contraindications, yog li nws yog qhov zoo dua kom yoo nqhis ntawm kev siv ywj pheej ntawm cov nyiaj.

Kev txheeb xyuas ntawm kev poob phaus txog cov tshuaj

Cov neeg mob uas kev rog dhau los hais lus txawv ntawm Lyraglutide. Ntawm ib txhais tes, ib hom tshuaj tuaj yeem pab tau kom daws tau ntau yam, thaum nws muaj txiaj ntsig zoo rau ntawm qab zib.

Tab sis tib lub sij hawm, cov tshuaj feem ntau ua rau cov tsos mob tsis zoo nyob rau hauv daim ntawv ntawm xeev siab thiab ntuav, uas feem ntau nyuaj rau ua taus. Tsis tas li ntawd, cov neeg mob ntaus nqi tus nqi siab rau qhov tsis zoo ntawm tus neeg sawv cev hypoglycemic, uas yog ib qho tseem ceeb ntawm qhov tsis kam txhaj tshuaj.

Thaum tsis muaj contraindications, tus kws kho mob tej zaum yuav qhia kev kho mob nrog Lyraglutide, nrog rau nws tuaj yeem txo qhov hnyav lub cev thiab ua kom cov ntshav qabzib ntau. Yuav kom ua tiav cov txiaj ntsig yam xav tau, nws yog qhov yuav tsum tau siv cov tshuaj kom raug, ntxiv kev kho mob nrog kev noj haus thiab ua kom lub cev qoj ib ce.