Dab tsi yog tee ntawm methyl ethyl pyridinol rau?
Qhov kev txhaj tshuaj yog qhov tseeb, tsis muaj xim lossis daj me ntsis.
1 ml | |
methylethylpyridinol hydrochloride | 10 mg |
Tshwjxeeb: hydrochloric acid 0.1 M tov - txog pH 2.5-3.5, dej d / i - txog 1 ml.
1 ml - iav ampoules (5) - hlwv pob (1) - pob khoom los ntawm cardboard.
1 ml - iav ampoules (5) - hlwv pob (2) - pob khoom los ntawm cardboard.
1 ml - iav ampoules (5) - pob khoom los ntawm cardboard.
1 ml - iav ampoules (10) - pob khoom los ntawm cardboard.
Pharmacological kev txiav txim
Angioprotector, txo qhov permeability ntawm phab ntsa vascular, yog ib qho inhibitor ntawm cov txheej txheem dawb radical, antihypoxant thiab antioxidant.
Txo cov ntshav viscosity thiab platelet ua ke, nce cov ntsiab lus ntawm cyclic nucleotides (cAMP thiab cGMP) hauv platelets thiab cov leeg hlwb, muaj cov haujlwm fibrinolytic, txo qhov permeability ntawm lub vascular phab ntsa thiab qhov kev pheej hmoo ntawm hemorrhage, txhawb lawv cov resorption. Nthuav cov hlab ntshav, thaum lub sij hawm mob myocardial infarction txwv qhov loj me ntawm kev ua kom pom tseeb ntawm necrosis, txhim kho kev cog lus ntawm lub plawv thiab txoj haujlwm ntawm nws txoj kev ua haujlwm. Nrog rau nce ntshav siab muaj cov nyhuv hypotensive. Hauv cov kev mob ischemic mob tsis zoo ntawm cov hlab hlwb txo qhov mob ntawm cov tsos mob neurological ntau, nce cov ntaub so ntswg tiv thaiv hypoxia thiab ischemia.
Nws muaj retinoprotective cov khoom, tiv thaiv lub retina los ntawm kev puas tsuaj ntawm lub teeb tsa hluav taws xob, ua kom cov resorption ntawm cov ntshav txhaws, txhim kho qhov muag microcirculation.
Tshuaj los qhia
Raws li ib feem ntawm cov kev kho mob nyuaj: kev rau txim ntawm cerebrovascular kev sib tsoo ntawm ischemic thiab hemorrhagic xwm, raug mob taub hau, postoperative lub sijhawm ntawm epi- thiab subdural hematomas, mob myocardial infarction, kev tiv thaiv ntawm reperfusion syndrome, tsis txaus ntseeg angina pectoris.
Subconjunctival thiab mob ntshav khov, mob taub hau (nrog rau cov ntshav qab zib), chorioretinal dystrophy (suav nrog cov keeb kwm atherosclerotic), mob dystrophic keratitis, mob txha caj qaum, mob rau myopia, tiv thaiv ntawm lub qhov muag (thaum hnav tsom iav) thiab lub qhov muag ntawm lub qhov muag lub teeb ci hnyav (laser thiab lub hnub ci, nrog laser-coagulation), kev poob plig, mob thiab mob ntawm lub qhov muag, mob cataract (suav nrog kev tiv thaiv hauv tib neeg tshaj 40), phais qhov muag, mob tom qab kev phais mob r ntxhua khaub ncaws nrog choroid detachment.
ICD-10 cov lis dej numICD-10 code | Kev taw qhia |
F07 | Tus cwm pwm thiab kev coj cwj pwm vim muaj mob, puas tsuaj, lossis ua rau lub hlwb khiav tsis zoo |
F07.2 | Cov mob tom qab tus mob tsis xis nyob |
H20.2 | Lens iridocyclitis |
H21.0 | Hyphema |
H31.1 | Choroidal tsis zoo |
H31.2 | Cov kab mob qub qub ntawm choroid |
H34 | Retinal Vascular Occlusion |
H35.6 | Mob ntshav siab hauv lub hlwb |
H36.0 | Ntshav Qab Zib Retinopathy |
H52.1 | Myopia |
I20.0 | Tsis khov tsis khov lub taub hau |
I21 | Mob myocardial infarction |
I61 | Kev mob hlwb hauv lub plawv (hemorrhagic hom ntawm cerebrovascular sib tsoo) |
I63 | Cerebral infarction |
I69 | Lub txim ntawm cerebrovascular mob |
T26 | Cov cua sov thiab tshuaj lom neeg kub hnyiab tau txwv rau lub qhov muag thiab adnexa |
Kev noj tshuaj ntxiv
Hauv cov tshuaj neurology thiab kev kho plawv - iv hno (20-40 tee / min), 20-30 ml ntawm 3% kev daws (600-900 mg) 1-3 zaug hauv ib hnub rau 5-15 hnub (yav tas los cov tshuaj tau diluted hauv 200 ml ntawm 0.9% NaCl daws lossis 5% dextrose daws). Lub sijhawm tiv thaiv yog nyob ntawm chav kawm ntawm tus kabmob. Tom qab, lawv hloov mus rau kev tswj hwm intramuscular - 3-5 ml ntawm 3% kev daws 2-3 zaug ib hnub rau 10-30 hnub.
Hauv ophthalmology - subconjunctival lossis parabulbar, 1 lub sijhawm hauv ib hnub lossis txhua lwm hnub. Subconjunctival - 0.2-0.5 ml ntawm 1% kev daws (2-5 mg), parabulbar - 0.5-1 ml ntawm 1% tov (5-1 mg). Lub sijhawm tiv thaiv yog 10-30 hnub, nws yog qhov ua tau kom rov ua qhov kawm 2-3 zaug nyob rau ib xyoos.
Yog tias tsim nyog, retrobulbar hauv 0.5-1 ml ntawm 1% daws 1 zaug nyob rau ib hnub rau 10-15 hnub.
Txhawm rau tiv thaiv qhov retina thaum lub ntsej muag laser coagulation (suav nrog nrog kev txwv thiab kev ua kom tsis txhob coagulation ntawm cov qog) - parabulbar lossis retrobulbar 0.5-1 ml ntawm 1% kev daws 24 teev thiab 1 teev ua ntej coagulation, tom qab ntawd hauv tib lub tshuaj (0.5 ml txhua) 1% daws) 1 zaug hauv ib hnub rau 2-10 hnub.
Lub npe Kev Lag Luam
Hauv qhov xa tawm ntawm cov xaib tawm, cov qhov muag pom tau hu ua Emoxipin, nrog cov khoom tseem ceeb ua ke methylethylpyridinol (methylethylpiridinol). Nws cov kev daws teeb meem hauv kev daws yog 1%, i.e., 1 ml ntawm cov tshuaj muaj 10 mg ntawm cov khoom tseem ceeb.
Qhov muag tso tawm muaj nyob hauv yas, nruab nrog dauv, cov kua muag muaj cov kua ntshiab thiab tsis muaj xim. Qhov ntim ntawm txhua tus yog 5 lossis 10 ml. Lub fwj tau ntim rau hauv cov thawv ntawv thawv nrog daim ntawv cov lus qhia ntxaws ntxaws.
Ib qho piv txwv ntawm cov tee no yog Emoxy-Optic.
Methylethylpyridinol tseem muaj nyob hauv 1 ml ampoules. Daim ntawv ntawm cov tshuaj no tseem siv los kho cov kab mob qhov muag thiab tuaj yeem siv tshuaj subcutaneously (qis dua ntawm lub qhov muag) los yog ncaj qha rau hauv lub orbit ntawm lub qhov muag (qis dua ib nrab ntawm lub pob muag). Cov hau kev ntawm kev tswj hwm tshuaj no yog siv hauv laser coagulation.
Raws li cov lus qhia, tee qhov muag ntawm Emoxipin tuaj yeem khaws cia ntawm t tsis siab tshaj + 25 ° C rau 2 xyoos, thiab tom qab qhib nws - tsis pub dhau 30 hnub. Qhov chaw khaws cia yuav tsum tiv thaiv los ntawm tshav ntuj ncaj qha thiab kom ncav cuag ntawm cov menyuam yaus.
Cov lus qhia rau siv: kev taw qhia thiab contraindications
Cov tshuaj kho qhov muag Emoksipin yog siv los kho qhov ntau ntawm cov qhov muag pathologies, lawv siv kuj ua tau rau cov hom phiaj prophylactic:
- Ntshav qab zib Angiopathy - ib qho kev cuam tshuam ntawm pathology nrog cov chav kawm ntev ntawm tus kab mob, qhia hauv qhov txhab ntawm cov hlab ntshav,
- Mob caj pas - pom qhov muag tsis pom kev nrog rau cov sij hawm los yog tas li kom muaj zog ntawm cov leeg siab,
- Myopia - myopia, thaum lub teeb ci nkag mus rau hauv lub qhov muag tsom mus rau ib kis tsis tau mus txog rau qhov retina. Raws li qhov tshwm sim, ib tus neeg tsis paub qhov txawv cov khoom ntawm qhov chaw nyob deb,
- Hypermetropia - farsightedness, rov qab ntawm myopia. Tus neeg mob pom tau zoo hauv qhov deb, thiab ze cov khoom tau plooj qhia,
- Kub yus lub qhov muag - kev puas tsuaj rau lub plhaub txheej sab nraud vim tias tshuaj lom neeg lub cev, siab t, UV hluav taws xob, vapors.
Nyeem ntxiv txog kab mob glaucoma ntawm no.
Methylethylpyridinol yog qhov ua tau txiaj ntsig zoo rau kev kho cov txheej txheem ua mob rau sab nraud o, nrog rau cov mob tom qab, thiab mob hnyav ntxiv ntawm kev mob txha caj qaum.
Tus txheej txheem qauv ntawm kev siv koom nrog instillation hauv txhua qhov muag 1 poob 2-3 zaug hauv ib hnub. Qhov nruab nrab ntawm kev kho mob yog 3-10 hnub. Txawm li cas los xij, raws li kws kho mob tau sau tseg, txoj kev qhia tuaj yeem txuas ntxiv mus txog 1 hlis. Txhim kho cov hauj lwm zoo ntawm kev kho yog ua tiav los ntawm kev saib xyuas qee txoj cai yooj yim:
- Ntxuav tes kom huv huv nrog xab npum ua ntej thiab tom qab ua tiav,
- Ua ntej siv cov tee, tshuaj xyuas seb puas muaj cov burrs ntawm qhov kawg uas tuaj yeem ua kev puas tsuaj rau lub qhov muag,
- Thaum instilling, tsis txhob kov lub dropper rau saum npoo ntawm lub qhov muag,
- Tom qab cov txheej txheem, kaw cov tawv muag, thiab tshem tawm cov dej noo uas tau tshwm sim nrog daim ntaub uas tsis huv,
- Tshem cov lo ntsiab muag ua ntej instillation hauv 15 feeb. , thiab hnav khaub ncaws tsis pub dhau 15 feeb. tom qab cov txheej txheem.
Koj tuaj yeem nyeem cov kab lus rau kev kuaj qhov muag ntawm no.
Thaum kho, qhov muag pom kev tsis meej, yog li ntawd, cov neeg uas ua cov haujlwm uas xav tau kev saib xyuas ntau ntxiv yuav tsum tau mus so.
Cov Yuav Tsum Tau Ua
Cov npe ntawm contraindications rau Emoxipin muaj qhov tsawg kawg ntawm cov khoom, nrog txhua yam khoom cuam tshuam nrog cov kev txwv feem ntau muaj nyob rau hauv yuav luag txhua yam yeeb tshuaj.
Kev siv qhov muag pom ntawm methylethylpyridinol nyob ib puag ncig ntawm cov kev mob hauv qab no yog txwv:
- Hypersensitivity rau cov tshuaj nquag thiab lwm yam,
- Tus neeg mob lub hnub nyoog tsis pub dhau 18 xyoo
- Lub sij hawm ntawm kev coj tus kheej thiab pub mis rau menyuam.
Kev saib xyuas tshwj xeeb yuav tsum tau saib xyuas hauv cov neeg mob uas muaj kev fab tawm tsam ua xua, tshwj xeeb tshaj yog thaum pib kho. Yog tias muaj qhov tsis xis nyob uas tsis ploj hauv ntau cov txheej txheem, kev kho yuav tsum tau txiav thiab ntxiv cov lus qhia kho mob yuav tsum tau txais.
Thaum cev xeeb tub
Lub sijhawm uas siv sijhawm (sijhawm xeeb tub) - ib qho ntawm lub luag haujlwm tseem ceeb hauv lub neej ntawm txhua tus poj niam. Ib qho tshuaj twg yog qhov tsis xav ua thaum cev xeeb tub, vim hais tias yeej ib txwm muaj tsawg kawg yog qhov me me ntawm qhov muaj qhov tsis zoo rau tus menyuam hauv plab. Qee yam tshuaj muaj peev xwm nkag mus rau qhov tso cov me nyuam.
Yog lawm, thaum siv cov tee qhov muag, cov nqos tau tshwm sim muaj tsawg heev. Txawm li cas los xij, methyl ethyl pyridinol yog cov tshuaj muaj zog uas cuam tshuam rau ntau cov txheej txheem hauv lub cev hauv lub cev.
Qhov txiav npluav ntawm kev siv cov tshuaj yog raws li cov tsis muaj ntaub ntawv txaus ntseeg ntawm cov txiaj ntsig ntawm nws txoj kev siv, txij li, ib txwm siv, tsis muaj kev ntsuas rau tus poj niam cev xeeb tub. Yog li, vim tias cov tshuaj yog ntawv sau tshuaj, nws txoj kev siv rau kev kho mob yog nyob ntawm kev txiav txim siab ntawm tus kws kho mob.
Retinal macular degeneration - kev kho mob nrog tshuaj ntsuab tshuaj thiab cov tshuaj tau piav qhia hauv cov kab lus no.
Cov menyuam yaus
Hais txog kev kho mob rau menyuam yaus, txoj kev qhia pom meej txog hnub nyoog txog 18 xyoo - ua ntej ntawd, lawv tsis pom zoo kom kho menyuam yaus. Txawm li cas los xij, qee cov tuam ntxhab tseem xa mus rau qhov tseeb tias qhov kev txwv no kuj yog los ntawm qhov tsis txaus ntseeg ntawm kev ua tau zoo ntawm kev siv cov tshuaj.
Nyeem ntxiv txog qhov muag tee Dexamethasone ntawm qhov txuas.
Hauv kev xyaum, cov kws kho mob menyuam yaus feem ntau pom zoo Emoxipine txawm rau cov menyuam yaus tshiab, vim tias cov menyuam yaus siv tshuaj rau qee qhov muag pathologies tsuas tsis muaj.
Muaj teeb meem tshwm sim los ntawm cov tshuaj
Kev ntsuas tus neeg mob pom tias feem ntau cov tshuaj tiv thaiv zoo. Muaj qee zaus, qhov tsis hnov mob nyob rau hauv daim ntawv ntawm kev tsis haum yog qhov ua tau: hlawv, khaus, liab, lacrimation.
Kev siv sib xyaw nrog lwm cov tshuaj, Nws raug nquahu kom siv Methylethylpyridinol kawg, tom qab sijhawm ntev li 15 feeb. tom qab thov tshuaj kawg.
Txog poob rau qhov muag Tsiprolet yog sau hauv kab lus.
Raws li cov tshuaj analogues ntawm cov tshuaj, Emoxy-optic, Emoxipin-AKOS, Emoxibel tuaj yeem siv tau.
Cov tshuaj no yog cov tshuaj siv tau zoo heev uas tuaj yeem muaj txiaj ntsig zoo cuam tshuam ntau cov txheej txheem hauv cov metabolism hauv lub qhov muag cov leeg. Yog li ntawd, nws txoj kev siv rau kev kho mob thiab kho hom phiaj tuaj yeem tsim nyog nyob rau hauv lub xub ntiag ntawm tus naj npawb ntawm pathologies, zoo li nrog cov kev hem thawj ntawm lawv txoj kev loj hlob.
Txawm hais tias qhov tseeb tias cov tshuaj yog txhais tau tias ntawm kev kis thoob plaws, nws txoj kev siv yuav tsum ua kom raug thiab nqa tawm tsuas yog nyob hauv kev saib xyuas ntawm ophthalmologist.
Kuj nyeem txog cov tshuaj xws li ciprofloxacin tee hauv cov khoom siv.
Tso tawm daim ntawv thiab muaj pes tsawg leeg
Dosage form - txhaj tshuaj: ntshiab, tsis muaj kob lossis kua daj ua kua, 1 ml txhua qhov hauv ampoules ntawm nruab nrab ntshiab iav los yog iav nrog hydrolysis tsis kam kawm ntawm HGA1, hauv pob ntawv los ntawm 5 lossis 10 ampoules tiav nrog ampoule scarifier (thaum ntim ampoules nrog tus caws pliav tsis tau ntxig nrog lub nplhaib lossis cov taw tes tawg) lossis 1-2 lub pob contour ntim ntawm 5 ampoules thiab cov lus qhia rau kev siv Methylethylpyridinol, ntim khoom rau tsev kho mob - hauv cov thawv ntawv ntawm 4, 5, 10, 50 lossis 100 cell contour pob. 5 vials.
Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj:
- cov tshuaj nquag: methylethylpyridinol (hauv daim ntawv ntawm hydrochloride) - 10 mg,
- Cov khoom ua haujlwm pabcuam: 0.1 M hydrochloric acid daws, dej rau kev txhaj tshuaj.
Cov Tshuaj Hauv Tshuaj
Methylethylpyridinol yog ib qho tshuaj antioxidant, ib qho inhibitor ntawm cov txheej txheem dawb.
Nws muaj cov txiaj ntsig zoo ntawm cov ntshav coagulation system: nws txo cov viscosity ntawm cov ntshav, lengthens lub sijhawm ntawm nws cov coagulation, thiab inhibits platelet aggregation. Nws ua kom lub zog ntawm cov qe ntshav liab thiab cov hlab ntshav, ntxiv cov tsis kam ntawm cov ntshav liab rau hemolysis thiab kev ua haujlwm raug mob.
Nws nce cov ntsiab lus ntawm cyclic nucleotides nyob rau hauv cov platelets (cyclic adenosine monophosphate thiab cyclic guanosine monophosphate), txo cov permeability ntawm vascular phab ntsa, txhawb kev resorption ntawm hemorrhages, thiab muaj cov haujlwm fibrinolytic.
Txhim kho microcirculation nyob rau hauv cov ntaub so ntswg ntawm lub qhov muag, suav nrog cov hlab ntsha ntawm cov tshuaj retina. Nws muaj cov nyhuv retinoprotective, tiv thaiv tus retina los ntawm kev cuam tshuam los ntawm lub teeb ntsig siab.
Kev ntsuas rau siv
Methylethylpyridinol yog siv ua ib feem ntawm txoj kev kho rau cov kab mob / mob hauv qab no:
- dystrophic kab mob ntawm lub pob kws,
- thaj tsam hauv ib qho ntshav ntawm lub cev thiab ntau yam keeb kwm,
- central thiab peripheral chorioretinal dystrophy,
- angioretinopathy (suav nrog tus mob ntshav qab zib),
- angiosclerotic macular degeneration (ntawv qhuav),
- thrombosis ntawm hlab ntsha nruab nrab ntawm Retina thiab nws cov ceg,
- muaj teeb meem ntawm myopia,
- Thib 2 kub hnyiab thiab mob rau lub qhov muag,
- detachment ntawm choroid nyob rau hauv lub sijhawm postoperative tom qab kev phais mob glaucoma,
- qhov muag puas tsuaj nrog lub siab siv (lub teeb hluav taws xob thaum lub laser coagulation) - kev kho thiab kev tiv thaiv.
Methylethylpyridinol, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas
Methylethylpyridinol txhaj tshuaj tov yog muab tshuaj parabulbarno (s / b) lossis subconjunctival (s / c). Cov tshuaj yog siv ua ib feem ntawm txoj kev kho mob.
Cov tshuaj xav kom ntau npaum:
- dystrophic kab mob ntawm lub pob zeb: s / c 0.5 ml ib hnub ib zaug nyob rau hauv chav kawm ntawm 10-30 hnub,
- Kev tso ntshav thiab tso ntshav tawm ntawm ntau lub hauv paus: s / c lossis p / b 0.5 ml ib hnub ib zaug rau 10-15 hnub,
- qhov nruab nrab thiab ntu txhawm chorioretinal dystrophy, qhuav daim ntawv ntawm angiosclerotic macular degeneration: 0.5 ml p / b ib hnub ib zaug rau 10-15 hnub,
- thrombosis ntawm txoj leeg nruab nrab ntawm tus Retina thiab nws cov ceg: n / ib 0.5 ml ib hnub ib zaug ntawm 10 hnub,
- nyuaj myopia: p / b 0.5 ml ib zaug ib hnub rau 10-30 hnub, yog tias tsim nyog 2-3 zaug hauv ib xyoos, rov ua cov chav kawm,
- kev raug mob thiab kub nyhiab ntawm lub qhov muag txog qib thib 2: p / b 0.5 ml 1 zaug nyob rau ib hnub rau 10-15 hnub,
- kev tshem tawm ntawm cov choroid nyob rau tom qab lub sijhawm ua haujlwm tom qab kev phais mob txhawm rau lub ntsej muag: s / c lossis p / b, 0.5-1 ml txhua txhua lwm hnub, kev kho mob muaj 10 txhaj tshuaj,
- kev tiv thaiv retinal thaum lub ntsej muag laser coagulation (suav nrog nrog kev txwv thiab kev ua kom cov qog ua pob): 0.5-1 ml p / b 24 teev thiab 1 h ua ntej coagulation, tom qab ntawd 0.5 ml ib hnub ib rau 2-10 hnub.
Sab sij huam
- cov tshuaj tiv thaiv hauv zos: kev hlawv, mob, hyperemia, khaus, kev cog lus ntawm cov nqaij mos paraorbital (tsis tas yuav kho tshwj xeeb, daws nws tus kheej),
- kev ua xua: khaus, tev ntawm daim tawv nqaij, edema, hyperemia,
- los ntawm lub paj hlwb: nkees nkees, ntxhov siab ncua luv,
- los ntawm cov hlab plawv system: cov tawv nqaij ua pob, nce ntshav siab.
Yeeb tshuaj sib cuam tshuam
Methyl ethyl pyridinol tsis yog tshuaj sib xyaw nrog lwm cov tshuaj, yog li nws raug txwv tsis pub coj los sib xyaw nrog cov tshuaj qub nrog rau lwm cov tshuaj.
Cov qauv siv ntawm Methylethylpyridinol yog: Vixipin, Cardioxypine, Methylethylpyridinol-Eskom, Emoxy-kws kho qhov muag, Emoxibel, Emoxipin, Emoxipin-AKOS, thiab lwm yam.
Kev tshuaj xyuas txog Methylethylpyridinol
Kev txheeb xyuas txog methylethylpyridinol tsawg tsawg, tab sis muaj qhov zoo. Cov tshuaj tau pom tias qhov ua tau zoo, tsis muaj txiaj ntsig.Txawm li cas los xij, raws li cov neeg mob, nws yooj yim dua rau kev siv yeeb tshuaj nrog tib cov tshuaj yeeb dej caw hauv daim ntawv ntawm qhov muag.
Methylethylpyridinol feem ntau yog siv ob qho tib si rau ntau yam kab mob ophthalmological, zoo li rau kev mob plawv thiab mob ntshav ntawm lub plawv.
Methylethylpyridinol: cov nqi hauv cov khw muag tshuaj online
Methylethylpyridinol 10 mg / ml txhaj rau 1 ml 10 pcs.
Methylethylpyridinol daws d / nyob rau. 10 mg / ml amp. 1ml №10 ELLARA
Kev Kawm: Rostov State Medical University, tshwj xeeb "General Tshuaj".
Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!
Nws tau siv los ua yawning enriches lub cev nrog oxygen. Txawm li cas los xij, lub tswv yim no tau sib kis. Cov kws tshawb fawb tau ua pov thawj tias yawning, ib tus neeg ua kom lub hlwb txias thiab txhim kho kev ua haujlwm.
Tus neeg muaj kev kawm paub tsis yooj yim rau cov kab mob hlwb. Cov kev txawj ntse ua haujlwm koom nrog kev tsim cov ntaub so ntswg ntxiv los txhawb rau cov neeg mob.
Lub siab yog qhov ua haujlwm hnyav tshaj plaws hauv peb lub cev. Nws qhov hnyav nruab nrab yog 1.5 kg.
Yog tias koj poob los ntawm tus nees luav, koj nyiam yob koj lub caj dab ntau dua li yog koj ntog los ntawm nees. Tsuas tsis sim rau refute nqe lus no.
Muaj 74 xyoo nyob hauv tebchaws Australian yawg James Harrison tau los ua neeg muab ntshav li 1,000 zaus. Nws muaj ib hom ntshav uas tsis tshua muaj, cov tshuaj tiv thaiv uas pab cov menyuam mos liab uas muaj ntshav tsawg txaus kom ciaj sia taus. Yog li, Australian thiaj cawm tau ntau txog ob lab tus menyuam.
Qhov ua kom pom kev vibrator ua ntej nyob rau xyoo 19th. Nws ua haujlwm ntawm lub tshuab tso hluav taws xob thiab nws tau npaj kho qhov mob poj niam.
Tib neeg cov ntshav "khiav" los ntawm cov hlab ntsha hauv qab qhov siab thiab, yog tias nws txoj kev ncaj ncees tau ua txhaum, tuaj yeem tua mus txog 10 meters.
Cov kws tshawb fawb los ntawm Oxford University tau ua cov kev tshawb fawb, thaum lub sijhawm lawv tau los txiav txim siab tias kev tsis noj zaub ua rau muaj kev puas tsuaj rau tib neeg lub hlwb, vim tias nws ua rau nws txo qis hauv nws qhov loj. Yog li cov kws tshawb fawb pom zoo kom tsis txhob cais cov ntses thiab nqaij los ntawm lawv cov kev noj haus.
Hauv 5% ntawm cov neeg mob, antidepressant clomipramine ua rau lub orgasm.
Thaum lub neej, tus neeg nruab nrab tsim tawm tsis tsawg tshaj li ob lub pas dej loj uas muaj qaub ncaug.
Thaum lub sijhawm ua haujlwm, peb lub hlwb siv ntau npaum li cas ntawm lub zog sib npaug rau 10-watt lub teeb lub teeb. Yog li cov duab ntawm lub teeb txawb saum koj lub taub hau thaum lub sijhawm pom ntawm qhov kev xav zoo nkauj tsis yog deb ntawm qhov tseeb.
Cov kws kho hniav tau tshwm sim tsis ntev los no. Rov qab rau hauv lub xyoo pua puv 19, nws yog lub luag haujlwm ntawm tus kws tu plaub hau kom rub tawm cov hniav mob.
Cov tshuaj muaj npe zoo "Viagra" tau tsim thaum chiv thawj los kho kev mob ntshav siab los ntawm arterial tawg.
Cov poj niam feem ntau muaj peev xwm tau txais kev lom zem ntau dua los ntawm kev xav txog lawv lub cev zoo nkauj hauv daim iav dua li ntawm kev sib deev. Yog li, cov poj niam, siv zog ua kom sib luag.
Ntau cov tshuaj tau xub pib ua lag luam li tshuaj. Piv txwv li yeeb dawb, tau pib ua lag luam ua tshuaj hnoos. Thiab cocaine tau pom zoo los ntawm cov kws kho mob ua tshuaj loog thiab yog lub zog ntawm kev ua kom lub siab ntev.
Polyoxidonium yog hais txog cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Nws ua rau qee yam ntawm lub cev tsis muaj zog, yog li ua rau muaj kev ntseeg ruaj khov ntawm.
Cov Tshuaj Pharmacokinetics
Kev faib khoom ntim - 5.2 litres. Kev tshem tawm ib nrab-lub neej yog 18 feeb. Kev daws tag nrho yog 0.2 l / min. Cov tshuaj txiav tawm hauv daim siab. Nws yog tawm los ntawm lub raum.
Raws li ib feem ntawm txoj kev kho:
- Kev koom ua ke thiab kev sib txuam ntawm ntau lub hauv paus,
- Angioretinopathy (suav nrog tus mob ntshav qab zib),
- Nruab nrab thiab nruab nrab chorioretinal dystrophy,
- Mob ntsws nruab nrab ntawm cov leeg ntshav nraub qaum thiab nws cov ceg ntoo,
- Lwm yam mob ntawm myopia
- Angiosclerotic macular degeneration (ntawv qhuav),
- Kev txiav txim siab ntawm tus choroid nyob rau tom qab lub sijhawm txiav txim siab tom qab kev phais mob glaucoma,
- Dystrophic kab mob ntawm lub pob zeb,
- Kev raug mob, hlawv rau lub qhov muag,
- Kev kho thiab tiv thaiv qhov muag ntawm qhov muag nrog lub teeb siab tshaj plaws (hnub ci, duab hluav taws xob thaum lub sijhawm laser coagulation).
Tsuas tshuaj thiab tswj hwm
Cov tshuaj yog siv ua ib feem ntawm txoj kev kho mob.
Nrog subconjunctival thiab mob ntshav khov ntawm ntau lub hauv paus - subconjunctival lossis parabulbar 0.5 ml ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-15 hnub.
Nrog angioretinopathy (suav nrog tus mob ntshav qab zib) - parabulbarno 0.5 ml 1 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 10 hnub.
Nrog lub hauv paus thiab mob ntawm qhov chorioretinal dystrophy, as Well as antisclerotic macular degeneration (daim ntawv qhuav) - parabulbar 0.5 ml ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-15 hnub.
Nrog thrombosis ntawm central retinal leeg thiab nws cov ceg - parabulbarno 0.5 ml ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-15 hnub.
Hauv kev cog qoob loo myopia - parabulbarno 0.5 ml ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-30 hnub, nws muaj peev xwm rov ua dua chav kawm 2-3 zaug hauv ib xyoos.
Nrog rau kev tshem tawm ntawm cov choroid hauv cov neeg mob uas mob txhav hauv lub sijhawm postoperative - parabulbar lossis subconjunctival 0.5-1.0 ml ib zaug txhua 2 hnub. Lub chav kawm ntawm kev kho mob yog 10 hno.
Rau kev raug mob thiab kub hnyiab ntawm lub qhov muag ntawm lub qhov thib 2 - parabulbarno 0.5 ml ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-15 hno.
Nrog dystrophic kab mob ntawm lub pob zeb - subconjunctival 0.5 ml ib zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 10-30 hnub.
Txhawm rau tiv thaiv qhov retina thaum lub ntsej muag laser coagulation (suav nrog nrog kev txwv thiab rhuav tshem cov qog nqaij hlav), 0.5-1.0 ml ntawm 1% tov (5-10 mg) parabulbarly 24 teev thiab 1 teev ua ntej coagulation, tom qab ntawd hauv tib lub tshuaj 0.5 ml ntawm 1% kev daws) 1 zaug hauv ib hnub rau 2-10 hnub.
Noj ntau dhau
Yog tias muaj kev noj ntau dhau, qhov nce ntxiv ntawm qhov hnyav ntawm qhov tsis haum tshuaj ntau ntxiv yog qhov ua tau.
Cov tsos mob: mob ntshav siab, ntxhov siab lossis tsaug zog, mob taub hau, mob lub siab, xeev siab, tsis xis nyob hauv thaj chaw epigastric. Muaj feem los ntshav txawv.
Kev Kho Mob: Kev tshem tawm yeeb tshuaj, mob tshwm sim, tsis muaj ib qho tshuaj tua kab mob.
Cov lus qhia tshwj xeeb
Kev kho mob nrog methylethylpyridinol yuav tsum tau ua nyob rau hauv kev tswj hwm ntawm cov ntshav siab thiab ntshav coagulation.
Cuam Tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog tshuab
Nrog rau kev txhim kho kev qaug zog, nws yog ib qho tsim nyog yuav tsum tsis kam tsav tsheb thiab lwm yam kev txav mus los, thiab tseem yuav tsum ceev faj thaum ua cov haujlwm uas muaj kev phom sij uas xav tau kev nce siab ntawm kev saib xyuas thiab ceev ntawm lub hlwb kev xav.
Kev piav qhia ntawm cov tshuaj nquag Methylethylpyridinol / Methylaethylpiridinolum.
Cov mis C8H11NO, tshuaj lub npe: 3-hydroxy-6-methyl-2-ethylpyridine hydrochloride.
Pharmacological pawg: cov tshuaj hematotropic / cov tshuaj tiv thaiv kab mob hauv lub cev, tshuaj metabolism / antihypoxants thiab tshuaj tua kab mob, cov tshuaj tiv thaiv organotropic / cov tshuaj tiv thaiv lub plawv / cov tshuaj ua kom lub plawv tsis sib xws thiab cov tshuaj tua kab mob microcirculation kho, organotropic tshuaj / ophthalmic.
Pharmacological kev txiav txim: antihypoxic, antiaggregational, antioxidant, angioprotective, retinoprotective.
Cov chaw muag tshuaj
Methylethylpyridinol yog ib qho angioprotector, antihypoxant thiab antioxidant, muaj cov khoom retinoprotective. Methylethylpyridinol inhibits cov txheej txheem dawb tshaj dhau. Methylethylpyridinol stabilizes cell daim nyias nyias. Methylethylpyridinol txhim kho microcirculation. Methyl ethyl pyridinol txo platelet kev sib sau thiab cov ntshav viscosity, txo tag nrho cov coagulation index, lengthens cov ntshav coagulation lub sijhawm, nce cov ntsiab lus ntawm cyclic nucleotides (cyclic guanidine monophosphate thiab cyclic adenosine monophosphate) hauv cov leeg hlwb thiab platelets. Methylethylpyridinol muaj cov kev ua haujlwm fibrinolytic, ntxiv dag zog rau cov leeg ntsa, txo cov permeability ntawm phab ntsa vascular thiab muaj kev pheej hmoo ntawm cov ntshav, txhawb kev resorption ntawm hemorrhages. Methylethylpyridinol tswj lub zog ntawm cov qe ntshav liab thiab cov hlab ntsha, ua kom cov ntshav qog ua ntshav rau hemolysis thiab kev raug mob ntawm lub tshuab. Methylethylpyridinol tsub kom cov kev ua ntawm antioxidant enzymes, zoo inhibits dawb radical oxidation ntawm lipids ntawm biomembranes. Methylethylpyridinol muaj cov nyhuv antitoxic, ua kom lub zog cytochrome P-450. Hauv cov xwm txheej huab, uas yog nrog hypoxia thiab nce lipid peroxidation, methylethylpyridinol ua rau cov txheej txheem xyoob ntoo zoo dua qub. Hauv kev mob ischemic cerebrovascular sib txawv, methylethylpyridinol txo qhov hnyav ntawm cov leeg mob, ua kom cov nqaij mos tsis kam rau ischemia thiab hypoxia. Thaum muaj teeb meem cerebrovascular (hemorrhagic thiab ischemic), methylethylpyridinol ua rau kev txhim kho ntawm cov kabmob ua haujlwm tsis haum, txhim kho mnemonic kev ua haujlwm, thiab pab txhawb kev kho kom rov zoo ntawm kev ua haujlwm hauv lub hlwb. Methylethylpyridinol txo qhov tsim ntawm triglycerides, muaj lipid-txo cov nyhuv. Methylethylpyridinol dilates cov hlab ntshav ntawm lub plawv, txo ischemic kev puas tsuaj rau myocardium, txhim kho kev ua haujlwm ntawm kev ua haujlwm ntawm lub plawv thiab lub plawv sib kis. Methylethylpyridinol txwv qhov loj me ntawm kev ua kom pom tseeb ntawm necrosis, nrawm nrawm los kho cov txheej txheem, normalizes cov metabolism hauv lub plawv mob hauv myocardial infarction. Methylethylpyridinol muaj cov txiaj ntsig zoo ntawm kev soj ntsuam chav kawm ntawm myocardial infarction, txo qhov tshwm sim ntawm cov mob plawv tsis ua haujlwm. Yog tias ua rau mob tsis ua haujlwm, methylethylpyridinol ua rau cov kev cai ntawm qhov kev rov ua dua. Nrog rau cov mob ntshav siab, methyl ethyl pyridinol muaj cov txiaj ntsig hypotensive. Methylethylpyridinol tiv thaiv cov retina los ntawm kev puas tsuaj ntawm lub teeb ntsig loj, txhim kho qhov muag microcirculation, thiab pab daws cov teeb meem hauv plab.
Thaum sau rau hauv cov kab mob sib xyaw ua ke, methylethylpyridinol sai sai nkag mus rau cov ntaub so ntswg ntawm lub qhov muag, qhov twg nws tau tso thiab metabolized. Qhov kev nkag siab ntawm methylethylpyridinol hauv cov ntaub so ntswg ntawm lub qhov muag siab dua hauv cov ntshav. Nws khi rau cov ntshav plasma protein ntau kwv yees li 42%. Nrog kev tswj hwm ntawm cov tshuaj methylethylpyridinol ntawm kev noj tshuaj ntawm 10 mg / kg, ib nrab hnub luv (18 feeb) tau pom, uas qhia tau muaj ntau tus nqi ntawm tshem tawm cov methylethylpyridinol los ntawm cov ntshav. Txoj kev tshem tawm tas li yog 0.041 feeb. Methylethylpyridinol sai sai nkag mus rau hauv cov ntaub so ntswg thiab cov kabmob, qhov chaw nws tso thiab metabolized. Cov pom tseeb ntawm kev faib tawm ntawm methylethylpyridinol yog 5,2 litres. Kev tshem tawm tag nrho ntawm methylethylpyridinol yog 214.8 ml / min. Tsib metabolites tau pom, uas tau sawv cev los ntawm dealkylated thiab ua cov methylethylpyridinol hloov khoom. Methylethylpyridinol yog tshuaj tiv thaiv hauv lub siab. Cov teeb meem loj ntawm 2-ethyl-6-methyl-3-hydroxypyridine-phosphate raug tshawb pom hauv daim siab. Methyl ethyl pyridinol metabolites yog ua tawm los ntawm lub raum. Hauv cov kab mob pathological, piv txwv li, nrog rau kev mob plawv ntsig txog, kev sib raug zoo ntawm cov tshuaj methylethylpyridinol hloov pauv: tus nqi nthuav tawm tau tsawg zuj zus, vim tias qhov bioavailability ntawm methylethylpyridinol nce, qhov chaw nyob lub sijhawm ntawm methylethylpyridinol nyob rau hauv cov hlab ntshav nce, uas yuav yog vim nws rov qab los ntawm depotoc, suav nrog ischemic.
ischemic mob stroke, hemorrhagic mob hlab ntsha hauv lub sijhawm rov qab, mob cerebrovascular tsis txaus, hloov pauv ntawm cerebrovascular, raug mob ntawm cerebrovascular thiab hemorrhagic thiab ischemic cerebrovascular kev sib tsoo, raug mob hlwb, tom qab lub sijhawm ntawm epidural thiab subdural hematomas.
kev tiv thaiv ntawm cov mob reperfusion syndrome, mob myocardial infarction, tsis khov ntawm cov leeg peinais.
mob plawv thiab subconjunctival hemorrhage, hemorrhages nyob rau hauv anterior chav ntawm lub qhov muag, hemorrhages nyob rau hauv sclera rau cov neeg laus (nrog rau kev tiv thaiv), angioretinopathy (suav nrog rau mob ntshav qab zib angioretinopathy), dystrophic keratitis, angiosclerotic maculodystrophy (qhuav mob ua paug, mob ntshav tawm, mob ntshav qab zib, mob ua kom tsis muaj zog) nruab nrab ntawm cov leeg ntawm cov retina thiab nws cov ceg, chorioretinal dystrophy (suav nrog chorioretinal dystrophy ntawm atherosclerotic keeb kwm), kev tiv thaiv ntawm lub qhov muag (thaum hnav x lo ntsiab muag) thiab tus retina los ntawm kev kis lub teeb ntsig loj (nrog laser coagulation, lub hnub zawv plaub hau thiab lub cev kub hnyiab laser), cov kab mob dystrophic ntawm lub qhov muag, muaj teeb meem ntawm myopia, cataracts (suav nrog kev tiv thaiv cataracts hauv tib neeg tshaj 40), kev poob plig, mob thiab kub ntawm lub qhov muag, mob tom qab phais mob hais txog kev mob lub ntsej muag nrog choroid detachment, kev phais mob hauv qhov muag.
Txoj kev siv cov methylethylpyridinol thiab koob tshuaj
Methylethylpyridinol yog muab tshuaj rau hauv pob txha khov, intramuscularly, subconjunctival, parabulbar, retrobulbar, instill rau hauv cov kab mob sib xyaw ua ke.
Hauv kev kho mob kab noj hniav, txhim kho 1 mus rau 2 tee (1% kev daws) 2 rau 3 zaug hauv ib hnub, lub sijhawm ntawm cov chav kawm ntawm kev kho mob thiab txiav txim siab los ntawm tus kws kho mob (feem ntau 3 mus rau 30 hnub), yog tias cov tshuaj zoo txaus thiab yog tias qhia, chav kawm ntawm txoj kev kho tau txuas ntxiv mus txog 6 lub hlis lossis rov ua dua 2 txog 3 zaug hauv ib xyoos.
Subconjunctival lossis parabulbar muab tshuaj ib hnub ib zaug lossis txhua lwm hnub. 0.2 - 0.5 ml ntawm 1% kev daws teeb meem (2 - 5 mg) yog muab tshuaj subconjunctively, 0.5 - 1 ml ntawm 1% tov (5 - 10 mg) tau muab tshuaj parabulbarly, lub sijhawm kho yog 10 - 30 hnub, nws muaj peev xwm rov ua dua chav kawm, yog tias tsim nyog, 2 txog 3 zaug hauv ib xyoos. Yog tias tsim nyog, retrobulbar 0.5 mus rau 1 ml ntawm 1% kev daws teeb meem yog muab ib hnub ib zaug rau 10 txog 15 hnub. Thaum lub sijhawm laser coagulation (suav nrog kev ua kom puas thiab ua kom cov ntshav sib xyaw nrog cov qog), retrobulbar lossis parabulbar 0.5 mus rau 1 ml ntawm 1% tov ib hnub thiab ib teev ua ntej coagulation raug tswj los tiv thaiv retina, tom qab li 0.5 ml ntawm 1% kev daws yog muab ib zaug ib hnub rau 2 txog 10 hnub.
Angioretinopathy (suav nrog rau mob ntshav qab zib angioretinopathy): 0.5 ml parabulbarno (10 mg / ml methylethylpyridinol tov) ib hnub ib zaug, kev kho mob ntawm 10 hnub. Subconjunctival thiab mob ntshav khov ntawm ntau lub hauv paus: parabulbarno lossis subconjunctival 0.5 ml (10 mg / ml methylethylpyridinol tov) ib hnub ib zaug, kev kho mob ntawm 10-15 hnub. Cov kab mob hauv nruab nrab thiab sab qaum chorioretinal dystrophy, angiosclerotic macular degeneration (daim ntawv qhuav): 0.5 ml parabulbarno (methylethylpyridinol tov 10 mg / ml) ib hnub ib zaug, kev kho mob yog 10-15 hnub. Qhov mob myopia: 0.5 ml parabulbarno (methylethylpyridinol tov 10 mg / ml) ib hnub ib zaug, chav kawm ntawm kev kho yog 10-30 hnub, ib chav kawm yuav rov ua dua 2 mus rau 3 zaug hauv ib xyoos. Mob ntsws cov hlab ntsha leeg ntawm cov retina thiab nws cov ceg: 0.5 ml parabulbarno (methylethylpyridinol tov 10 mg / ml) ib hnub ib zaug, kev kho mob ntawm 10-15 hnub. Kev txiav txim siab ntawm choroid nyob rau hauv cov neeg mob lub ntsej muag txhawm rau lub sijhawm postoperative: subconjunctival lossis parabulbar 0.5 txog 1.0 ml (10 mg / ml methylethylpyridinol tov) ib zaug txhua 2 hnub, chav kawm ntawm kev kho mob yog 10 txhaj. Dystrophic kab mob ntawm lub qhov muag: subconjunctival 0.5 ml (10 mg / ml methylethylpyridinol tov) ib zaug ib hnub, cov chav kawm ntawm kev kho yog 10-30 hnub. Kev raug mob thiab kub hnyuv ntawm lub qhov muag ntawm lub qhov txhab thib ob: 0.5 ml parabulbarno (cov tshuaj methylethylpyridinol 10 mg / ml) ib hnub ib zaug, chav kawm ntawm txoj kev kho yog 10-15 hno.
txhaj koob tshuaj (20-40 tee ib feeb), 20-30 ml ntawm 3% tov (600-900 mg) 1 mus rau 3 zaug hauv ib hnub rau 5-15 hnub, nyob ntawm qhov ntsuas thiab chav kawm ntawm tus kab mob (pre-diluted nrog methyl ethyl pyridinol 200 ml ntawm 5% kev daws teeb meem ntawm dextrose lossis 0.9% daws ntawm sodium chloride), tom qab ntawd lawv hloov mus rau kev txhaj tshuaj intramuscular - 3-5 ml ntawm cov tshuaj 3% 2 rau 3 zaug hauv ib hnub rau 10 txog 30 hnub.
muab cov tshuaj txo qis (20-30 tee ib feeb) hauv koob tshuaj 5-10 mg / kg rau 10-12 hnub, tom qab ntawd hloov mus rau kev txhaj tshuaj ntawm 2-10 ml (daws nrog qhov muaj txog 30 mg / ml) (60-300 mg ) 2 mus rau 3 zaug hauv ib hnub rau 10 txog 30 hnub.
Methylethylpyridinol yog siv ua ib feem ntawm kev kho mob nyuaj.
Kev kho mob nrog methyl ethyl pyridinol yuav tsum tau ua nyob rau hauv kev tswj hwm ntawm kev sib xyaw ua ke thiab tiv thaiv kab mob ntawm cov ntshav thiab cov ntshav siab.
Yog tias nws yuav tsum tau siv tshuaj methylethylpyridinol ua lub ntsej muag tshuaj nrog rau lwm cov tshuaj nyob rau hauv daim ntawv ntawm lub qhov muag, methylethylpyridinol yog instilled kawg tom qab ua tiav kev nqus ntawm cov tshuaj dhau los (tsawg kawg 15 feeb).
Thaum lub sijhawm kho nrog methyl ethyl pyridinol, tshwj xeeb tshaj yog thaum qaug zog, txo qis ntshav siab, nws raug nquahu kom tsis txhob koom ua cov haujlwm uas muaj peev xwm txaus ntshai uas xav tau kev nce siab ntawm kev saib xyuas thiab ceev ntawm psychomotor tshua (suav nrog kev tsav tsheb, kev siv tshuab).
Cev xeeb tub thiab lactation
Kev siv cov methylethylpyridinol yog sib kis thaum lub sijhawm cev xeeb tub thiab lactation, vim tias tsis muaj kev tshawb fawb txaus thiab tswj xyuas kev nyab xeeb ntawm methylethylpyridinol thaum cev xeeb tub thiab lactation. Thaum kho nrog methyl ethyl pyridinol, kev pub mis rau menyuam yuav tsum nres.