Vasotens H (Vasotens® H)

Vazotens N: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Vasotenz H

ATX Code: C09DA01

Tus nquag ua hauj lwm: losartan (Losartan) + hydrochlorothiazide (Hydrochlorothiazide)

Chaw tsim tshuaj paus: Actavis hf. (Iceland), Actavis, Ltd. (Malta)

Hloov kho cov lus piav qhia thiab yees duab: 07/11/2019

Cov nqi hauv khw muag tshuaj: los ntawm 375 rubles.

Vazotens N yog qhov kev siv tshuaj tiv thaiv kev tiv thaiv kabmob.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage form - film-coated tablets: puag ncig, biconvex, nrog kev phom sij thiab kev pheej hmoo ntawm ob sab ntawm lub ntsiav tshuaj, ntawm ib sab ntawm cov kev pheej hmoo muaj daim ntawv lo "LH", nyob rau lwm qhov - "1" (ntau npaum 50 mg + 12.5 mg) lossis “2” (noj 100 mg + 25 mg) (hauv cov hlwv ntim 7, 10 lossis 14 pcs., hauv ib pob ntawv 2 los yog 4 leeg ntawm 7 ntsiav tshuaj, lossis 1, 3, 9 lossis 10 hlwv ntawm 10 ntsiav tshuaj, lossis 1 lossis 2 lub hlwv rau 14 ntsiav tshuaj thiab cov lus qhia rau siv Vazotenza N).

Composition 1 ntsiav tshuaj:

• cov khoom ua haujlwm nquag: losartan poov tshuaj - 50 lossis 100 mg, hydrochlorothiazide - 12,5 lossis 25 mg, feem
• excipients: croscarmellose sodium, microcrystalline cellulose, mannitol, magnesium stearate, povidone, Dawb Opadrai (hypromellose 50cP, hypromellose 3cP, titanium dioxide, macrogol, hydroxypropyl cellulose).

Cov Tshuaj Hauv Tshuaj

Vazotens N yog hypotensive tshuaj ntawm kev sib xyaw ua ke.

Cov khoom muaj tshuaj:

• losartan yog qhov kev paub tseeb angiotensin II receptor antagonist (subtype AT1). Txo cov ntshav siab (BP), tag nrho peripheral vascular tsis kam (OPSS), muaj ntshav siab nyob rau hauv cov hlab ntsws, ua kom cov adrenaline thiab aldosterone nyob rau hauv cov ntshav, txo qis tom qab, muaj cov nyhuv diuretic. Hauv cov neeg mob uas muaj lub plawv tsis ua hauj lwm ntev, nws tiv thaiv kev txhim kho ntawm myocardial hypertrophy thiab ua rau lub cev muaj zog tsis ua haujlwm. Tsis inhibit kinase II - ib qho enzyme uas rhuav tshem bradykinin,
• hydrochlorothiazide yog thiazide diuretic. Txo cov reabsorption ntawm sodium ions, txhim kho kev pom zoo ntawm bicarbonate, phosphate thiab potassium ions hauv cov zis.

Yog li, Vazotens N txo cov khoom ntim ntawm cov ntshav ncig, hloov lub cev hloov ntawm cov vascular phab ntsa, txhim kho kev nyuaj siab ntawm cov laiblie, txo cov nyhuv pressor ntawm vasoconstrictors, yog li txo cov ntshav siab.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, losartan nrawm nrawm rau lub plab zom mov (GIT). Nws yog tsiag ntawv los ntawm kev tsis tshua muaj kev nyab xeeb, tivthaiv

33% Nws muaj cov nyhuv ntawm thawj zaug kis los ntawm lub siab. Nws yog cov tshuaj tiv thaiv kab mob los ntawm carboxylation, uas ua rau muaj qhov tsis muaj zog ntawm metabolites thiab cov tshuaj pharmacologically nquag metabolite (E-3174). Kwv yees li 99% ntawm cov koob tau khi rau cov ntshav plasma. Tom qab noj Vazotenza N sab hauv, qhov siab tshaj plaws ntawm losartan tau tiav hauv 1 teev, qhov nquag metabolite - 3-4 teev Ib nrab-lub neej (T_½) losartan - 1.5-2 teev, E-3174 - 3-4 teev. Nws tshwm: los ntawm txoj hnyuv - 60% ntawm qhov koob tshuaj, ob lub raum - 35%.

Tom qab kev tswj hwm ntawm qhov ncauj, hydrochlorothiazide nrawm rau hauv cov hnyuv. Tsis muaj pluas noj hauv lub siab. T_½ - 5.8-14.8 teev Feem ntau (

61%) yog tawm tsis hloov pauv hauv cov zis.

Cov Yuav Tsum Muaj

• arterial siab hypotension,
• mob raum tsis zoo QC (creatinine tshem tawm) ≤ 30 ml / min,
• mob siab ua rau daim siab,
• hypovolemia (suav nrog tiv thaiv keeb kwm ntawm kev tso tshuaj ntau ntawm diuretics),
• anusia
• hnub nyoog txog 18 xyoo
• cev xeeb tub thiab lactation
• hypersensitivity rau losartan, hydrochlorothiazide, lwm yam sulfonamide derivatives los yog ib qho ntu ntawm cov tshuaj.

Tus txheeb ze (Vasotens N yuav tsum tau siv nrog kev ceev faj):

• kev ua txhaum ntawm cov dej-electrolyte sib npaug ntawm cov ntshav (lub cev qhuav dej, hypochloremic alkalosis, hyponatremia, hypokalemia, hypomagnesemia),
• ob leeg lub raum leeg mob stenosis los yog leeg ntshav ntawm ib raum,
• hypercalcemia, hyperuricemia thiab / lossis gout,
• mob ntshav qab zib mellitus
• cov kab mob cov kab mob ntawm cov nqaij sib txuas (suav nrog cov kab mob lupus erythematosus),
• keeb kwm kev tsis haum,
• bronchial hawb pob,
• siv tib lub sij hawm ntawm cov tshuaj uas tsis muaj tshuaj steroidal (NSAIDs), suav nrog COX-2 inhibitors (cyclooxygenase-2).

Sab sij huam

Thaum siv Vazotenza H, kev mob tshwm sim yuav tshwm sim thaum noj cov vitamins losartan thiab / lossis hydrochlorothiazide.

Cov tshwm sim tsis zoo:

• los ntawm cov hlab plawv system: cim txo hauv ntshav siab,
• los ntawm cov hnyuv hauv plab: tsis tshua muaj (1%, vim losartan yog ib feem ntawm cov tshuaj) - raws plab, mob siab,
• ntawm ib feem ntawm cov txheej txheem ua pa: hnoos (vim qhov ua ntawm losartan),
• ua kom tawv nqaij thiab ua xua: urticaria, angioedema (suav nrog o ntawm daim di ncauj, pharynx, larynx thiab / lossis tus nplaig), uas tuaj yeem ua rau muaj kev cuam tshuam ntawm txoj hlab ua pa, tsis tshua muaj tshwm sim (vim qhov ua los ntawm losartan) - vasculitis, suav nrog Tus kab mob Shenlein-Genoch,
• kev kuaj pom: tsis tshua muaj - hyperkalemia (ntshav poov tshuaj> 5.5 mmol / l), muaj ntau ntxiv kev ua haujlwm ntawm daim siab enzymes.

Nrog rau qhov tseem ceeb tawg, kev mob tshwm sim feem ntau yog kiv taub hau.

Noj ntau dhau

Thaum tus neeg noj haus ntau dhau lawm, losartan tuaj yeem ua rau cov kev mob tshwm sim hauv qab no: lub cim txo rau hauv cov ntshav siab, bradycardia, tachycardia.

Kev noj tshuaj ntau dhau ntawm hydrochlorothiazide tuaj yeem tshwm sim los ntawm qhov ploj ntawm electrolytes (hyperchloremia, hypokalemia, hyponatremia), nrog rau lub cev qhuav dej, uas yog ib qho txiaj ntsig ntawm ntau qhov diuresis.

Yog tias lub sijhawm me ntsis tau dhau mus txij li noj Vazotenza N, kev mob plab zom zaub mov yog qhov pom zoo. Cov tsos mob thiab kev txhawb nqa kev kho mob yog qhov tsim nyog; yuav tsum kho cov dej-electrolyte cuam tshuam. Yog tias tsim nyog, hemodialysis tau ua tiav kom tshem tawm losartan thiab nws cov metabolite nquag tawm ntawm lub cev.

Hydrochlorothiazide

Thaum siv tshuaj kho mob, nws yog qhov yuav tsum tau saib xyuas tus neeg mob kom thiaj li paub pom sai sai ntawm cov tsos mob uas tau pom tias muaj kev cuam tshuam ntawm cov dej-electrolyte tshuav, uas yuav tshwm sim tiv thaiv keeb kwm ntawm mob plab zawv lossis ntuav. Hauv cov neeg mob zoo li no, nws tseem tsim nyog los tswj qib ntawm electrolytes hauv cov ntshav cov ntshav.

Thiazide diuretics tuaj yeem cuam tshuam nrog kev ua kom lub ntsej muag tuaj yeem, uas yuav xav tau kev kho kom haum ntawm ib tus neeg sawv cev hypoglycemic lossis insulin.

Hydrochlorothiazide yuav txo qis cov calcium calcium tawm tsis zoo ntxiv, nrog rau ua rau qee qhov mob me ntsis ntawm cov calcium ntau ntau. Yog tias kuaj pom mob hypercalcemia loj, yuav tsum pom tias muaj tus kab mob hyperparathyroidism tsis txaus.

Thiazides cuam tshuam rau cov metabolism hauv calcium, yog li ntawd, lawv tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev kawm txog kev ua haujlwm ntawm cov qog parathyroid. Hauv qhov no, nyob rau Hmo ua ntej qhov kev xeem, tshuaj yuav tsum tau muab tso tseg.

Hydrochlorothiazide tuaj yeem nce ntshav triglycerides thiab roj (cholesterol).

Thaum lub sij hawm kho, exacerbation los yog mob ntawm cov kab ke lupus erythematosus yog ua tau.

Hydrochlorothiazide tuaj yeem ua rau kev loj hlob ntawm hyperuricemia thiab / lossis gout. Txawm li cas los xij, losartan, qhov tseem ceeb thib ob ntawm Vazotenza N, txo cov uric acid cov ntsiab lus, yog li ntawd, txo qhov hnyav ntawm hyperuricemia tshwm sim los ntawm cov diuretic.

Tawm tsam keeb kwm ntawm diuretic txoj kev kho, qhov tshwm sim ntawm kev ua kom lub siab tsis haum yog qhov ua tau, txawm tias cov neeg mob uas tsis muaj keeb kwm tsis muaj mob ntsws lossis mob ua xua.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov kev kho mob tshwj xeeb los kawm txog cov nyhuv ntawm Vazotenza N ntawm tib neeg lub hlwb thiab lub hlwb kev ua haujlwm tsis tau coj los ua. Txawm li cas los xij, thaum kho, kiv taub hau thiab tsaug zog tuaj yeem tshwm sim. Vim li no, kev ceeb toom yog qhia thaum ua haujlwm ua haujlwm xav tau kev mloog ntxiv thiab ceev ntawm cov tshuaj tiv thaiv, tshwj xeeb tshaj yog nyob rau theem pib ntawm txoj kev kho thiab thaum lub sijhawm nce cov koob tshuaj.

Cev xeeb tub thiab lactation

Thaum siv nyob rau zaum ob thiab thib peb lub cev xeeb tub, losartan, zoo li lwm yam tshuaj uas cuam tshuam rau renin-angiotensin-aldosterone system (RAAS), tuaj yeem ua rau muaj kev txhim kho ntawm cov leeg nqaij thiab tseem tuag.

Hydrochlorothiazide hla lub cev placental, yog txiav txim siab hauv cov ntshav ntawm txoj hlab ntaws. Thaum siv thaum cev xeeb tub, nws muaj feem yuav muaj kev daj ntseg ntawm cov menyuam hauv plab lossis menyuam mos, nrog rau thrombocytopenia thiab niam electrolyte tsis txaus.

Vasotens N ntsiav tshuaj muaj contraindicated thaum cev xeeb tub. Yog tias kuaj pom lub cev muaj zog thaum kho cov tshuaj, koj yuav tsum tshem tawm sai li sai tau.

Thiazide diuretics dhau mus rau hauv niam cov kua mis. Tus poj niam raug pom zoo kom tsis txhob pub mis niam yog tias kho tshuaj thaum lub sijhawm lactation yog kho kom zoo.

Yeeb tshuaj sib cuam tshuam

Losartan tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv kabmob (diuretics, sympatholytics, beta-blockers). Tib lub sijhawm, kev sib nrig sib cuam tshuam ntawm cov nyhuv yog sau tseg.

Tsis muaj kev sib txuam los ntawm kev siv tshuaj uas muaj kev sib txuam nrog kev siv tib lub sijhawm ntawm hydrochlorothiazide, erythromycin, cimetidine, ketoconazole, phenobarbital, warfarin, digoxin.

Hauv cov neeg mob uas txo BCC vim yog kev kho yav dhau los nrog cov tshuaj diuretics ntau heev, cov tshuaj yuav ua rau muaj kev cuam tshuam ntawm cov ntshav siab.

Nrog kev sib koom ua ke ntawm kev siv cov tshuaj potassium-sparing diuretics (amiloride, triamteren, spironolactone), cov ntsev ntsev ntawm cov tshuaj tua ntsev los yog hauv cov tshuaj potassium, kev nce ntxiv hauv cov theem ntawm cov potassium nyob hauv cov ntshav cov ntshav tau.

Fluconazole thiab rifampicin txo cov ntshav plasma theem ntawm cov metabolite nquag ntawm losartan. Cov chaw kab mob tseem ceeb ntawm cov kev sib txuam no tsis tau tsim.

Losartan muaj peev xwm nce cov ntsiab lus ntawm lithium hauv cov ntshav ntshav. Hauv kev hais txog qhov no, cov roj ntsha lithium tuaj yeem tsim kho tsuas yog tom qab ua tib zoo ntsuas kev ntsuas ntawm cov txiaj ntsig tsim nyog thiab cov kev pheej hmoo txaus ntshai. Thaum siv txoj kev sib xyaw ua ke no, cov ntshav plasma concentration ntawm lithium yuav tsum tau ua tib zoo saib xyuas.

Cov nyhuv ntawm losartan tuaj yeem txo los ntawm NSAIDs, suav nrog xaiv COX-2 inhibitors. Hauv cov neeg mob uas lub raum khiav tsis zoo, muaj qee qhov, qhov kev sib txuam no tuaj yeem pab ntxiv kev ua kom lub raum ua tau ntxiv, mus txog rau kev txhim kho ntawm lub raum tsis ua haujlwm. Cov nyhuv no feem ntau thim rov qab.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

nyob rau hauv ib lub hlwv ntim 7 pcs., nyob rau hauv ib pob ntawv ntawm 4 phaus ntawv, los yog hauv ib lub hlwv ntawm 14 pcs., nyob rau hauv ib pob ntawv ntawm 2 cardboard.

nyob rau hauv ib lub hlwv ntim 7 pcs., nyob rau hauv ib pob ntawv ntawm 4 phaus ntawv, los yog hauv ib lub hlwv ntawm 14 pcs., nyob rau hauv ib pob ntawv ntawm 2 cardboard.

Kev sib txuam

Losartan txhim kho cov nyhuv ntawm lwm cov tshuaj tiv thaiv antihypertensive. Tsis muaj qhov sib cuam tshuam hauv chaw kho mob nrog hydrochlorothiazide, digoxin, cov tshuaj tiv thaiv tsis tseem ceeb, cimetidine, phenobarbital, ketoconazole, erythromycin tau sau tseg. Cov tshuaj Rifampicin thiab fluconazole tau qhia tawm txog qib qis ntawm cov tshuaj lom metabolite. Cov kab mob tseem ceeb hauv cov kev sib txuam tsis tau kawm.

Raws li kev tswj hwm ntawm lwm cov tshuaj uas thaiv cov tshuaj angiotensin II los yog nws cov kev nqis tes ua, kev ua haujlwm ntawm kev noj cov zaub mov poov tshuaj zoo ib zaug (piv txwv li spironolactone, triamteren, amiloride), kev npaj tshuaj poov tshuaj, lossis ntsev hloov uas muaj cov tshuaj potassium yuav ua rau mob hyperkalemia.

NSAIDs, suav nrog xaiv COX-2 inhibitors tuaj yeem txo cov txiaj ntsig ntawm diuretics thiab lwm tus neeg sawv cev antihypertensive.

Hauv qee tus neeg mob uas lub raum tsis zoo uas tau kho nrog NSAIDs (suav nrog COX-2 inhibitors), kev kho mob nrog angiotensin II receptor antagonists tuaj yeem ua rau kev tsis taus ntawm lub raum ua haujlwm ntxiv, suav nrog mob raum tsis ua haujlwm, uas feem ntau yog thim rov qab.

Cov nyhuv antihypertensive ntawm losartan, zoo li lwm cov tshuaj tiv thaiv kabmob, tuaj yeem ua kom tsis muaj zog thaum noj tshuaj indomethacin.

Cov tshuaj yeeb yaj kiab hauv qab no tuaj yeem cuam tshuam nrog thiazide diuretics nrog kev tswj hwm hauv lawv:

barbiturates, narcotic tshuaj, ethanol - orthostatic hypotension tuaj yeem muaj hwj chim,

cov kab mob hypoglycemic (cov tshuaj tiv thaiv kab mob hauv qhov ncauj thiab insulin) - Yuav tsum tau txhaj tshuaj kho tus kab mob ntshav qog ntshav tsawg,

lwm cov tshuaj tiv thaiv kabmob ntshav - ntxiv cov nyhuv yog tau,

colestyramine thiab colestipol - txo qhov nqus ntawm hydrochlorothiazide,

corticosteroids, ACTH - nce hluav taws xob ntau, tshwj xeeb tshaj yog poov tshuaj,

pressor amines - tej zaum qhov kev poob qis me ntsis hauv cov nyhuv ntawm pressor amines, tsis cuam tshuam nrog lawv siv,

tsis-depolarizing nqaij relaxants (xws li tubocurarine) - nws yog ua tau los txhim kho qhov kev txiav txim ntawm cov leeg ua si,

lithium npaj - kev siv tshuaj kho kom zoo dua qhov ua kom lub raum ua kom tsis muaj teeb meem Li + thiab nce qhov kev pheej hmoo ntawm lithium intoxication, yog li ntawd, kev siv txhij ib zaug tsis pom zoo,

NSAIDs, suav nrog xaiv COX-2 inhibitors - hauv qee cov neeg mob, siv cov NSAIDs, suav nrog COX-2 inhibitors, tuaj yeem txo cov diuretic, natriuretic thiab antihypertensive nyhuv ntawm diuretics.

Qhov cuam tshuam rau kev kuaj pom - Vim qhov cuam tshuam ntawm cov calcium excretion, thiazides tuaj yeem cuam tshuam txog kev soj ntsuam parathyroid muaj nuj nqi.

Tsuas tshuaj thiab tswj hwm

Sab hauv tsis hais txog ntawm cov noj mov.

Cov koob tshuaj ib txwm pib thiab txij nkawm yog 1 ntsiav tshuaj. ib hnub. Rau cov neeg mob uas tuaj yeem tsis ncav cov ntshav siab txaus tswj hwm ntawm cov tshuaj no, tuaj yeem nce ntxiv rau 2 ntsiav tshuaj. (50 mg / 12.5 mg) lossis 1 ntsiav tshuaj. (100 mg / 25 mg) 1 zaug nyob rau ib hnub. Qhov siab tshaj plaws yog 2 ntsiav tshuaj. (50 mg / 12.5 mg) lossis 1 ntsiav tshuaj. (100 mg / 25 mg) 1 zaug nyob rau ib hnub.

Nyob rau hauv dav dav, qhov siab tshaj plaws hypotensive nyhuv tiav nyob rau hauv 3 lub lis piam tom qab pib ntawm kev kho mob.

Tsis tas yuav muaj kev xaiv tshwj xeeb ntawm kev txhaj tshuaj thawj zaug rau cov neeg laus.

Cov lus qhia tshwj xeeb

Nws tuaj yeem tau sau ua ke nrog lwm cov tshuaj tiv thaiv antihypertensive.

Tsis tas yuav muaj kev xaiv tshwj xeeb ntawm kev txhaj tshuaj thawj zaug rau cov neeg laus.

Cov tshuaj muaj peev xwm ua rau muaj kev nce siab ntau ntxiv ntawm urea thiab creatinine hauv ntshav ntshav hauv cov neeg mob uas muaj ob sab mob raum leeg ntshav siab los yog cov raum leeg ntshav liab ntawm ib lub raum.

Hydrochlorothiazide tuaj yeem ua rau cov ntshav muaj zog thiab ua kom cov ntshav-electrolyte tshuav (txo hauv BCC, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), ua rau cov ntshav qabzib tsis tuaj yeem, txo qis ntshav calcium uas tsis tuaj yeem thiab ua rau muaj kev hloov pauv, nce ntxiv hauv plasma cholesterol, nce ntshav ntxiv ntawm cov ntshav qab zib hauv ntshav, nce ntshav ntxiv thiab triglycerides, ua rau qhov tshwm sim ntawm hyperuricemia thiab / lossis gout.

Txais ntawm cov tshuaj ncaj qha ua yeeb yam rau renin-angiotensin system thaum lub caij II thiab III txiav tawm cev xeeb tub tuaj yeem ua rau tuag hauv plab. Yog tias cev xeeb tub tshwm sim, kev tshem yeeb tshuaj yog qhia.

Tsis muaj cov ntaub ntawv hais txog cov txiaj ntsig ntawm qhov muaj peev xwm ntawm kev tsav lub tsheb thiab lwm cov tshuab.

Kev ntsuas rau siv

Cov tshuaj yog raug kho rau cov neeg mob uas muaj teeb meem ntau yam:

1. Arterial tawg. Cov tshuaj yog qhia rau cov neeg mob kub siab. Thaum noj cov tshuaj "Vazotens" nws yog qhov yuav tsum tau soj ntsuam ntsuas cov ntshav siab.
2. Mob plawv nres. Nrog kev muaj mob ntawm tus mob pathology, kev cog lus ntawm lub siab txo qis hauv cov neeg mob. Feem ntau, tus kab mob tau pom los ntawm cov neeg laus.

Cov tshuaj "Vazotens" yog tau sau ua ke nrog lwm cov tshuaj. Cov tshuaj zoo raug pom zoo thaum noj nrog ACE inhibitors. Tus kws kho mob yuav tsum tau suav txog qhov ua tau zoo ntawm kev kho thiab tus yam ntxwv ntawm lub cev.

Cov tshuaj yog tshuaj rau lub plawv tsis ua hauj lwm

Yuav ua li cas noj thiab nyob li cas siab, noj ntau npaum li cas

"Vazotens" yog kho rau cov neeg mob ntshav siab. Cov tshuaj tau noj ntawm qhov ncauj, tsis hais noj mov. Koj yuav tsum haus cov ntsiav tshuaj 1 zaug nyob rau ib hnub.

Yog tias cov neeg mob tau kuaj mob ntshav siab, kev kho mob pib nrog kev noj tshuaj tsawg kawg nkaus. Tus neeg mob tau sau ntawv 50 mg ntawm cov tshuaj uaartan. Yog tias tsim nyog thiab raws li kws kho mob cov lus pov thawj, ntau npaum li cas yuav nce tau txog 100 mg. Tom qab ntawd tus lej tau muab faib ua 2 koob tshuaj - thaum sawv ntxov thiab yav tsaus ntuj.

Cov neeg muaj lub plawv tsis ua haujlwm yuav tsum siv tshuaj tsawg kawg. Qhov tshuaj thawj zaug yog 12,5 mg ib hnub ib zaug. Yog tias tus neeg mob zam kev kho mob tau zoo, tom qab 7-10 hnub kev noj tshuaj ntau dua ntxiv.

Kws Tshuaj

Cov tshuaj Vazotens hais txog cov tshuaj tiv thaiv kev tiv thaiv kev mob siab - tshwj xeeb kev thaiv kev sib deev ntawm cov tshuaj angiotensin 2. Nws tsis txwv cov kinase enzyme, uas rhuav tshem bradykinin. Cov tshuaj muaj cov diuretic effect, tsis cuam tshuam rau cov ntsiab lus ntawm adrenaline, aldosterone hauv ntshav.

Vim tias kev txiav txim ntawm cov tshuaj, hypertrophy ntawm myocardial cov hlab ntsha tsis txhim kho, kam rau ua kom lub cev ua si nce nrog lub plawv tsis ua haujlwm. Tom qab txhaj tshuaj ib zaug xwb, lub siab poob qis, cov nyhuv nce mus txog nws qhov siab tshaj plaws tom qab 6 teev thiab kav ib hnub. Qhov ua tau zoo ntawm cov tshuaj tau tshwm sim ntawm 3-6 lub lis piam ntawm kev kho mob. Nrog mob qog ua haujlwm ntawm lub siab, qhov xav tau ntawm cov tshuaj nquag nce ntxiv, yog li yuav tsum tau txhaj tshuaj.

Losartan nrawm hauv lub plab, muaj 33% bioavailability. Cov tshuaj nce mus txog qhov siab tshaj plaws tom qab ib teev, qhov nquag metabolite - tom qab 3-4 teev. Ib nrab-lub neej ntawm losartan yog 1.5-2 teev, cov metabolite yog 6-9 teev. Ib feem peb ntawm koob tshuaj yog tawm hauv cov zis, tus so nrog quav.

Cov lus sib xyaw ntawm Vazotenza N suav nrog diuretic hydrochlorothiazide, uas yog hais txog thiazide-yam tshuaj yeeb dej caw. Nws txo qis reabsorption ntawm sodium ions, nce ntxiv ntawm kev tso zis ntawm phosphates, bicarbonate. Los ntawm kev txo qhov ntim ntawm cov ntshav ncig, ntshav qis, lub zog ntawm cov vascular hloov pauv, qhov cuam tshuam ntawm vasoconstrictors tsawg zuj zus, thiab cov nyhuv depressor rau cov ganglia nce.

Tsuas tshuaj thiab tswj hwm

Vazotens ntsiav tshuaj noj ib zaug ib hnub. Nrog rau kev kub siab, qhov koob tshuaj txhua hnub yog 50 mg, qee zaum nws nce ntxiv txog 100 mg hauv 1-2 koob tshuaj. Hauv lub plawv tsis ua haujlwm, kev muab tshuaj thawj zaug yog 12,5 mg ib hnub ib zaug. Cov koob tshuaj tau nce txhua lub lim tiam los ntawm 12.5 mg mus txog 50 mg ib hnub ib zaug. Nrog rau kev tswj hwm tib txhij ntawm cov tshuaj diuretics, thawj koob tshuaj txo yog 25 mg rau ib hnub.

Yog tias lub siab ua haujlwm tsis zoo (ua kom tsis txhob muaj cov kabmob creatinine), cov koob tshuaj tsawg zuj zus, hauv lub hnub nyoog laus, nrog lub raum tsis ua haujlwm, lim ntshav, kho tsis ua haujlwm. Qhov siab tshaj plaws tshwm sim tom qab 3 lub lis piam ntawm kev kho mob. Hauv chav kho mob hlwb, tshuaj tsis yog siv. Cov lus qhia tshwj xeeb rau nws siv los ntawm cov lus qhia:

1. Ua ntej sau ntawv yuav ib qho tshuaj, kev kho lub cev qhuav dej yog ua tiav, lossis koj yuav tsum siv cov tshuaj hauv ib qho qis.
2. Lub cuab yeej tuaj yeem nce qhov siab ntawm urea hauv cov ntshav nrog lub raum txhaws.
3. Thaum kho, nws yog qhov yuav tsum tswj cov qib poov tshuaj hauv ntshav, tshwj xeeb tshaj yog rau cov neeg laus, vim tias cov neeg mob li no muaj kev pheej hmoo ntawm kev loj hlob hyperkalemia (nce ntxiv ntawm cov poov tshuaj hauv ntshav plasma).
4. Kev siv cov tshuaj thaum cev xeeb tub tuaj yeem ua rau muaj kev txhim kho lossis tuag ntawm tus menyuam. Nrog rau lactation, kev siv cov vasotens yog txwv tsis pub.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Vazotens yog hais txog kev siv tshuaj kho mob, khaws cia hauv qhov kub txog 30 degrees txog tsis pub ntev tshaj 2 xyoos, tsis ncav cuag ntawm cov menyuam yaus.

Antihypertensive cov neeg sawv cev nrog sib txawv muaj pes tsawg leeg tuaj yeem hloov cov tshuaj. Vazotens analogs:

• Lorista - ntsiav tshuaj raws li losartan,
• Lozap yog ntsiav tshuaj npaj muaj losartan ua cov tshuaj nquag.

Lub Npe Tsis Muaj Npe International

INN ntawm cov tshuaj yog losartan.

Vasotens txoj kev kho yog feem ntau kho rau cov neeg mob los ntawm kev mob ntshav siab.

Hauv kev thoob ntiaj teb kev faib tawm ATX, cov tshuaj no muaj tus lej C09CA01.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov khoom xyaw tseem ceeb ntawm Vazotens yog potassium losartan. Cov tshuaj ntxiv ntawm cov tshuaj suav nrog croscarmellose sodium, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, thiab lwm yam. Cov lus sib xyaw ntawm Vazotenza N, ntxiv rau losartan, suav nrog hydrochlorothiazide.

Vasotens muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ntau npaum ntawm 25, 50 thiab 100 mg. Cov ntsiav tshuaj muaj puag ncig cov duab. Lawv tau npog nrog lub plhaub dawb thiab tau tsim "2L", "3L" lossis "4L" nyob ntawm seb ntau npaum li cas. Lawv tau ntim rau hauv cov hlwv ntawm 7 lossis 10 pcs. Hauv ib lub thawv ntawv cardboard muaj 1, 2, 3 lossis 4 lub hlwv thiab daim ntawv qhia nrog cov ntaub ntawv hais txog yeeb tshuaj.

Vasotens muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ntau npaum ntawm 25, 50 thiab 100 mg.

Pharmacological kev txiav txim

Cov yam ntxwv pharmacological ntawm cov tshuaj yog vim cov lus hais hypotensive kev ua haujlwm ntawm Vazotenz, lub ntsiab tseem ceeb ntawm cov uas yog hom 2 angiotensin receptor antagonist. Nrog vasotenz txoj kev kho, cov tshuaj nquag ntawm cov tshuaj pab txo OPSS. Cov tshuaj ua rau qis qis qis dua kev tso tawm ntawm aldosterone thiab adrenaline hauv ntshav ntshav. Cov tshuaj no muaj cov txiaj ntsig ntawm kev sib koom ua ke, pab txhawb rau qhov ib txwm tsis ua haujlwm ntawm lub siab hauv cov ntsws thiab txoj hlab ntsws.

Tsis tas li ntawd, cov nquag ua haujlwm ntawm cov tshuaj txo qis tsim txom cov kabmob rau lub plawv thiab muaj cov nyhuv diuretic. Vim tias cov nyhuv ua haujlwm nyuaj, kev kho mob nrog vasotens txo qhov kev pheej hmoo ntawm myocardial hypertrophy. Cov tshuaj no yuav pab txhawb kom muaj kev tawm dag zog hauv cov neeg mob uas muaj cov cim tsis zoo ntawm lub siab tsis ua haujlwm.

Cov tshuaj tsis cuam tshuam rau kev sib tov ntawm hom 2 kinase. Qhov enzyme no muaj kev cuam tshuam rau kev puas hlwb bradykinin. Thaum noj cov tshuaj no, txo qis ntshav siab yog pom tom qab 6 teev. Hauv lub sijhawm tom ntej, cov haujlwm ntawm cov tshuaj nquag ntawm cov tshuaj maj mam txo qis dua 24 teev. Nrog kev siv cov txheej txheem, qhov siab tshaj plaws pom tau pom tom qab 3-6 lub lis piam. Yog li, cov tshuaj yuav tsum tau siv lub caij nyoog ntev rau qhov kev siv.

Nrog saib xyuas

Yog tias tus neeg mob muaj cov cim tsis ua haujlwm ntawm lub siab thiab lub raum ua haujlwm, kev kho mob nrog Vazotens yuav tsum muaj kev tshwj xeeb ntawm tus kws kho mob. Ntxiv rau, kev saib xyuas tshwj xeeb yuav tsum tau siv cov vazotens hauv kev kho mob ntawm cov neeg kev txom nyem los ntawm tus kab mob Shenlein Genoch. Hauv qhov no, kev hloov kho tsis tu ncua ntawm cov tshuaj yuav tsum txo qis kev pheej hmoo ntawm kev tsim cov kev mob hnyav.

Yuav noj cov vasotens li cas?

Cov tshuaj no yog npaj rau lub luag haujlwm. Yuav kom ua tiav qhov kev kho kom zoo, tus neeg mob yuav tsum noj raws lub sijhawm teem sijhawm 1 zaug thaum sawv ntxov. Noj mov tsis cuam tshuam rau kev nqus ntawm cov tshuaj. Txhawm rau tswj cov ntshav siab thiab tswj hwm nws kom nyob rau theem qub, cov neeg mob tau qhia pom tias noj Vazotenza li ntawm 50 mg ib hnub twg. Yog tias tsim nyog, qhov koob tshuaj yuav raug nce ntxiv rau 100 mg ib hnub twg.

Yog tias tus neeg mob tau muaj cov cim qhia ntawm lub plawv tsis ua hauj lwm, maj mam nce ntxiv ntawm koob tshuaj vasotenz yog qhov kev pom zoo. Ua ntej, tus neeg mob yog kws kho mob ntawm ib koob tshuaj 12,5 mg ib hnub twg. Tom qab li ib lim piam, qhov koob tshuaj nce ntxiv rau 25 mg. Tom qab lwm 7 hnub tom qab noj cov tshuaj, nws qhov siab nce txog 50 mg rau ib hnub.

Yog tias tus neeg mob tau muaj cov cim qhia ntawm daim siab tsis ua haujlwm, kev kho mob nrog Vazotens yuav tsum muaj kev tshwj xeeb ntawm tus kws kho mob.

Nruab nrab hauv lub paj hlwb

Kwv yees li ntawm 1% ntawm cov neeg mob niaj hnub kho cov vasotens muaj cov tsos mob asthenia, mob taub hau, thiab kiv taub hau. Kev pw tsaug zog ntxhov siab, tsaug zog sawv ntxov, hnov ​​lub dag lub zog, cov cim ntawm ataxia thiab peripheral neuropathy mob tsawg yuav tshwm sim thaum kho vasotenz. Muaj peev xwm saj tsis txaus thiab pom qhov muag tsis zoo. Tsis tas li ntawd, muaj kev pheej hmoo ntawm lub cev tsis zoo ntawm lub cev.

Los ntawm genitourinary system

Noj cov vasotenza tuaj yeem tsim cov kev mob rau kev txhim kho kev sib kis ntawm cov mob txeeb zig. Muaj qee zaus, cov neeg mob muaj cov lus yws ntau zaus tso zis thiab ua rau lub raum khiav tsis zoo. Hauv cov txiv neej, nrog kev kho vasotenz, kev txo qis hauv libido thiab kev txhim kho ntawm impotence yuav pom.

Tej zaum qhov ua kom pom ntawm daim tawv nqaij qhuav.

Los ntawm cov hlab plawv system

Nrog kev kho vasotenz ntev ntev, tus neeg mob yuav tuaj yeem tsim orthostatic hypotension. Angina thiab tachycardia tawm tsam muaj peev xwm ua tau. Tsawg tsawg zaus, noj cov tshuaj ua rau muaj ntshav khiav.

Feem ntau, siv vasotenz ua rau muaj kev fab tshuaj tsis haum, qhia los ntawm khaus, urticaria, lossis ua pob rau ntawm daim tawv nqaij. Tsis tshua pom muaj kev txhim kho mob ntawm kev mob hlwb.

Siv thaum cev xeeb tub thiab lactation

Qhov kev ua tau zoo thiab kev nyab xeeb ntawm kev siv vasotenza thaum cev xeeb tub tsis tau kawm tag nrho. Hauv qhov no, muaj pov thawj pom qhov tsis zoo ntawm cov tshuaj ua kom muaj zog ntawm cov menyuam hauv plab 2 thiab 3 lub hlis ntawm cev xeeb tub. Qhov no yuav ua rau tus me nyuam muaj mob phom sij thiab ua rau nws tuag taus. Yog tias tsim nyog kho, kev tsis kam kom pub niam mis rau menyuam.

Nrog kev kho vasotenz ntev ntev, tus neeg mob yuav tuaj yeem tsim orthostatic hypotension.

Nqe rau vasotens

Tus nqi ntawm cov tshuaj hauv cov khw muag tshuaj zoo li ntawm 115 txog 300 rubles, nyob ntawm seb ntau npaum li cas.

Ib qho ntawm cov yeeb yaj kiab uas nrov tshaj plaws ntawm cov tshuaj yeeb yog Lozap.
Cozaar yog ib qho tshuaj noj ntawm cov tshuaj Vazotens.
Ib qho tshuaj zoo sib xws yog Presartan.
Cov tshuaj lom neeg ntawm cov tshuaj Vazotens yog Lorista.Lozarel yog ib qho ntawm cov paub zoo analogues ntawm cov tshuaj Vazotens.

Kev kho plawv

Grigory, 38 xyoo, Moscow

Hauv kuv txoj kev kho mob, Kuv feem ntau siv kev siv cov vazotens rau cov neeg mob uas mob ntshav liab. Vim tias cov tshuaj tiv thaiv hypotensive thiab diuretic ua ke, cov tshuaj tsis tsuas yog pab txhawb rau cov ntshav siab ib txwm, tab sis kuj tseem ua rau tus neeg mob lub siab nyiam mus tawm dag zog thiab txo qhov mob ntawm edema. Cov tshuaj tau zoo zam txim txawm tias cov neeg laus laus. Tsis tas li ntawd, nws yog qhov tsim nyog rau suav nrog hauv txoj kev kho mob siv cov tshuaj ntxiv los tiv thaiv kabmob.

Irina, 42 xyoo, Rostov-on-Don.

Kuv tau ua haujlwm ntawm kws kho plawv ntev dua 15 xyoos, thiab cov neeg mob tau txais kev tsis txaus siab ntawm cov ntshav siab feem ntau kho mob Vazotens. Cov nyhuv ntawm cov tshuaj no hauv feem ntau muaj txaus kom tswj tau lub siab tsis tas yuav tsum tau siv tshuaj txuas ntxiv. Cov tshuaj no tau pom zoo zoo los ntawm cov neeg mob thiab tsis tshua muaj kev phiv tshuaj. Ua tsaug rau qhov no, koj tuaj yeem siv nws hauv cov kev kawm ntev.

Igor, 45 xyoo, Orenburg

Feem ntau kuv pom zoo kom siv cov vasotenza rau cov neeg mob kev mob plawv. Cov tshuaj tso cai rau koj maj mam ua tiav qhov ua tau ntawm cov ntshav siab thiab txo qhov hnyav ntawm edema ntawm qis qis dua. Cov cuab yeej siv tau zoo nrog rau lwm cov tshuaj siv hauv kev kho ntawm tus kab mob no. Nyob rau kuv ntau xyoo ntawm kev xyaum, Kuv tsis tau ntsib qhov zoo li ntawm cov kev mob tshwm sim hauv cov neeg mob siv cov vazotens.

Thaum siv cov tshuaj, yuav tsum saib xyuas kom tswj hwm cov txheej txheem nyuaj.

Margarita, 48 xyoo, Kamensk-Shakhtinsky

Kuv tau paub txog qhov teeb meem ntshav siab tau ntau dua 15 xyoos. Thaum xub thawj, cov kws kho mob pom zoo kom txo qhov hnyav, tsis tu ncua taug kev hauv huab cua ntshiab thiab noj kom zoo, tab sis cov teeb meem tau maj mam zuj zus. Thaum lub siab pib ruaj khov thaum 170/110, cov kws kho mob tau pib sau ntawv noj tshuaj. Lub sijhawm 3 xyoo tas los Kuv tau raug kho nrog Vazotens. Cov cuab yeej muab cov txiaj ntsig zoo. Kuv coj nws thaum sawv ntxov. Lub siab tau ruaj khov. Kev o tuaj ntawm ob txhais ceg ploj mus. Tus pojniam nws pib zoo siab. Txawm tias nce ntaiv ntaiv tau muab tam sim no yam tsis muaj siav siav.

Andrey, 52 xyoo, Chelyabinsk

Nws noj ntau yam tshuaj rau siab. Kwv yees li ib xyoos, kws kho plawv kho mob hais kom siv vazotens. Cov cuab yeej muab cov txiaj ntsig zoo. Koj yuav tsum tau noj nws tsuas yog 1 ib hnub twg. Lub siab rov qab los ua kom nyob rau hauv tsuas yog 2 lub lim tiam ntawm kev txais. Tam sim no kuv siv cov tshuaj no txhua hnub. Kuv tsis pom ib qho tshwm sim dabtsi.