Cov tshuaj Insulin Protafan: cov lus qhia, cov khoom kuaj xyuas, tshuaj xyuas
- Cov Tshuaj Pharmacokinetics
- Kev ntsuas rau siv
- Txoj kev ntawm daim ntawv thov
- Sab sij huam
- Cov Yuav Tsum Tau Ua
- Cev xeeb tub
- Kev cuam tshuam nrog lwm yam tshuaj
- Noj ntau dhau
- Cia rau cov neeg mob
- Daim ntawv tso tawm
- Muaj pes tsawg leeg
- Yeem
Protafan NM - tshuaj tiv thaiv kab mob.
Cov suab thaj txo qis ntawm insulin yog los txhawb kev nce siab ntxiv cov piam thaj los ntawm cov ntaub so ntswg tom qab khi ntawm insulin rau cov txais ntawm cov leeg thiab cov rog, nrog rau kev cuam tshuam ntawm kev tso tawm cov piam thaj los ntawm lub siab.
Qhov nruab nrab, qhov txiav txim siab profile tom qab subcutaneous txhaj tshuaj yog raws li nram no: qhov pib ntawm kev ua yog nyob rau hauv 1.5 teev, qhov siab tshaj plaws ua haujlwm yog los ntawm 4 txog 12:00, lub sijhawm ua haujlwm yog kwv yees li 24 teev.
Cov Tshuaj Pharmacokinetics
Ib nrab ntawm lub neej ntawm insulin los ntawm cov ntshav yog ob peb feeb, yog li ntawd, qhov profile ntawm qhov kev ua ntawm qhov kev npaj insulin yog txiav txim siab tsuas yog los ntawm cov yam ntxwv nqus. Tus txheej txheem no nyob ntawm ntau yam (piv txwv li, ntawm qhov koob tshuaj insulin, txoj kev thiab qhov chaw txhaj tshuaj, qhov tuab ntawm cov nqaij subcutaneous, hom ntshav qab zib), uas txiav txim siab qhov txawv txav ntawm cov nyhuv ntawm cov tshuaj insulin hauv ib qho thiab cov neeg mob sib txawv.
Kev Tsis Txaus Siab Qhov siab tshaj plaws nyob rau hauv ntshav hauv ntshav tau ncav cuag li 2-18 teev tom qab kev tswj hwm ntawm cov tshuaj.
Kev xa Khoom. Cov xwm txheej tseem ceeb ntawm cov insulin rau cov ntshav plasma, tsuas yog zam ntawm cov ntshav ncig mus rau nws (yog tias muaj), tsis kuaj pom.
Kev zom zaub mov. Tib neeg cov insulin yog muab pov tseg los ntawm insulin proteases lossis insulindegradable enzymes thiab, tejzaum nws los ntawm protein disulfide isomerase. Ib tug xov tooj ntawm cov chaw tau txheeb xyuas qhov twg tawg (hydrolysis) ntawm tib neeg cov tshuaj insulin molecule tshwm sim. Tsis muaj ib qho ntawm cov metabolites tsim tom qab hydrolysis muaj kev ua haujlwm lom.
Chaw Sau Ntawv. Lub sijhawm ntawm ib nrab ntawm lub neej kawg ntawm insulin yog txiav txim siab los ntawm tus nqi ntawm nws nqus los ntawm subcutaneous ntaub so ntswg. Yog vim li cas lub sijhawm kawg ntawm ib nrab-lub neej (t½) qhia txog tus nqi ntawm kev nqus, thiab tsis yog tshem tawm (yog li ntawd) ntawm insulin los ntawm ntshav ntshav (t½ ntawm insulin los ntawm cov ntshav tsuas yog ob peb feeb). Raws li kev tshawb nrhiav, t½ yog 5-10 teev.
Txoj kev ntawm daim ntawv thov
Protafan NM yog cov insulin ua yeeb yam ntev ntev, yog li nws siv tau nyob ib leeg lossis siv ua ke nrog insulin luv luv.
Kev noj tshuaj ntawm cov tshuaj insulin yog tus kheej thiab txiav txim los ntawm tus kws kho mob raws li qhov xav tau ntawm tus neeg mob.
Cov kev xav tau rau ib hnub rau insulin feem ntau yog los ntawm 0.3 txog 1.0 IU / kg / hnub. Kev xav tau txhua hnub rau insulin tuaj yeem nce ntxiv hauv cov neeg mob uas muaj kev tiv thaiv insulin (piv txwv, hauv qhov puberty lossis kev rog) thiab txo qis hauv cov neeg mob uas muaj cov tshuaj insulin endogenous ntau lawm.
Koob tshuaj hloov kho
Cov kab mob tsis haum, tshwj xeeb tshaj yog kis mob thiab kub ib ce, feem ntau ua rau tus neeg mob xav tau cov tshuaj insulin. Mob raum, mob siab, lossis adrenal, mob hlwb, lossis qog cov thyroid xav kom hloov cov koob tshuaj.
Koob tshuaj kuj tseem yuav tau ua yog tias cov neeg mob hloov lawv lub cev ua si lossis lawv noj zaub mov ib txwm noj. Kev xaiv koob tshuaj kuj tseem xav tau thaum hloov cov neeg mob mus rau lwm yam tshuaj insulin.
Taw qhia
Protafan NM npaj rau kev txhaj tshuaj subcutaneous nkaus xwb. Ib qho kev tshem tawm insulin yog tsis muab tswj hwm.
Protafan HM ib txwm muab tshuaj rau hauv qab daim tawv nqaij ntawm tus ncej. Koj tuaj yeem nkag mus hauv thaj av ntawm thaj tsam ntawm anterior phab ntsa, pob tw los sis deltoid leeg ntawm lub xub pwg.
Nrog kev txhaj tshuaj subcutaneous mus rau hauv tus ncej puab, qhov nqus tshuaj insulin yog qeeb dua thaum txhaj rau lwm qhov ntawm lub cev.
Cov lus qhia ntawm kev kos tawm ntawm daim tawv nqaij quav txo qis kev pheej hmoo ntawm kev nkag mus rau hauv cov leeg nqaij.
Tom qab txhaj, koob yuav tsum nyob twj ywm hauv qab ntawm daim tawv nqaij tsawg kawg yog 6 feeb. Qhov no yuav ua kom paub meej ntawm kev qhia tag nrho cov tshuaj.
Txo qhov kev pheej hmoo ntawm lipodystrophy, qhov chaw txhaj tshuaj yuav tsum tau hloov tas li txawm tias nyob hauv tib lub cev.
Protafan NM hauv cov vials siv nrog cov tshuaj insulin tshwj xeeb, uas muaj qhov tsim nyog kawm tiav. Protafan HM los nrog cov lus qhia ntim nrog cov ncauj lus kom ntxaws rau kev siv.
Cov lus qhia rau kev siv tshuaj Protafan NM rau tus neeg mob
Tsis txhob siv Protafan NM:
- Nyob rau hauv kev lis ntshav twj,
- yog tias koj fab (hypersensitive) rau tib neeg cov kua dej los yog lwm yam tshuaj ntawm cov tshuaj
- yog tias koj xav tias koj tab tom txhim kho hypoglycemia (cov piam thaj hauv ntshav tsawg)
- yog hais tias lub hau yas muaj kev ruaj ntseg tsis haum snugly lossis ploj lawm
(Txhua lub raj mis muaj qhov tiv thaiv yas los qhia kev qhib, yog tias tau txais lub raj mis, lub taub hau tsis haum snugly lossis ploj lawm, lub raj mis yuav tsum rov qab mus rau lub tsev muag tshuaj)
- Yog hais tias cov tshuaj tau muab khaws cia tsis raug los yog raug txhuam,
- Yog hais tias qhov kev ncua ntawm insulin ua uniformly dawb thiab pos huab tom qab sib tov.
Ua ntej siv cov tshuaj Protafan NM:
- kos daim paib kom paub tseeb tias hom insulin yog raws li kws kho mob hais,
- tshem cov hau kev ruaj ntseg.
Yuav siv cov insulin npaj li cas
Protafan NM muab los ntawm kev txhaj tshuaj hauv qab daim tawv nqaij (subcutaneously). Tsis txhob txhaj tshuaj insulin ncaj qha mus rau txoj hlab ntshav lossis leeg. Txhua zaus yuav tsum hloov chaw txhaj tshuaj, txawm tias nyob hauv thaj tsam ntawm tib lub cev los txo qhov kev pheej hmoo ntawm kev tsim cov ntsaws ruaj ruaj lossis khoob ntawm daim tawv nqaij. Qhov chaw zoo tshaj plaws rau kev txhaj tshuaj rau tus kheej yog lub pob tw, hauv ntej ncej puab lossis nraub qaum.
Nkag rau Protafan NMyog tias nws tau muab tshuaj ib leeg lossis thaum sib xyaw nrog cov tshuaj insulin luv luv
- Nco ntsoov tias koj siv cov tshuaj insulin uas muaj qhov tsim nyog kawm tiav.
- Kos rau hauv lub koob txhaj tshuaj ib lub ntim ntawm cov huab cua sib npaug ntawm cov koob tshuaj insulin uas koj xav tau thiab nkag rau hauv lub thauv.
- Ua raws li cov lus qhia los ntawm koj tus kws kho mob lossis kws tu neeg mob hais txog cov txheej txheem rau kev tswj hwm cov tshuaj.
- Tam sim ntawd ua ntej siv, yob ib fwj ntawm Protafan ® NM nruab nrab ntawm koj xib teg kom txog thaum cov kua hloov dawb thiab cov huab. Kev sib tsoo zoo tshaj plaws thaum muaj cov tshuaj insulin los ua kom sov rau chav sov.
- Muab cov subulinaneous txhaj tshuaj ntawm cov tshuaj insulin. Siv cov txheej txheem txhaj tshuaj uas koj tus kws kho mob lossis tus neeg saib mob tau pom zoo.
- Tuav rab koob nyob hauv qab daim tawv nqaij tsawg kawg 6 vib nas this kom ntseeg tau tias qhov tshuaj tag nrho.
Cov menyuam. Kev npaj rau biosynthetic tib neeg cov tshuaj insulin yog qhov muaj txiaj ntsig zoo thiab muaj kev nyab xeeb rau kev kho mob ntshav qab zib hauv cov hnub nyoog sib txawv ntawm cov menyuam yaus thiab cov hluas. Kev xav tau insulin txhua hnub hauv cov menyuam yaus thiab cov hluas nyob ntawm theem ntawm tus kabmob, lub cev lub cev, hnub nyoog, kev noj zaub mov zoo, kev tawm dag zog, qib ntawm insulin tsis kam thiab qhov zoo ntawm qib glycemia.
Pharmacodynamics thiab pharmacokinetics
Nws yuav tsum raug sau tseg tias Protafan NM yog tshuaj insulin ib tus neeg muaj cov nyhuv nruab nrab ntev, tsim los ntawm cov qauv ntawm cov khoom siv roj ntsha DNA biotechnology siv hom tshuaj nruj Saccharomyces cerevisiaeCov. Cov tshuaj cuam tshuam nrog ib qho kev tshwj xeeb nyob rau sab nraud ntawm cytoplasmic cell membrane nrog kev tsim cov tshuaj insulin-receptor complex. Hauv qhov no, kev tsim tawm ntawm cov txheej txheem intracellular, piv txwv li, kev sib txuas ntawm qhov tseem ceeb cov enzymes: pyruvate kinase, hexokinase, glycogen synthetase thiab lwm tus.
Cauj nyob rau hauv muaj pes tsawg leeg ntshav nce vim nws txoj kev thauj mus los rau hauv siab, uas ua kom cov nqaij mos zoo li qub, nrog rau kev txhawb lipogenesis thiab glycogenogenesis, txo qis kev ua haujlwm ntawm cov piam thaj los ntawm daim siab, thiab lwm yam.
Hauv qhov no, Protafan insulin yog nqus ntawm tus nqi uas nyob ntawm ntau yam xws li ntau npaum li cas, txoj kev, txoj kev taug ntawm kev tswj hwm thiab hom ntshav qab zib. Vim li no, qhov profile ntawm insulin zoo tuaj yeem hloov pauv.
Cov tshuaj pib ua nyob rau hauv 1-1.5 teev txij li lub sijhawm ntawm kev tswj hwm, qhov siab tshaj plaws ua tiav tau tiav tom qab 4-12 teev thiab siv tau tsawg kawg yog 24 teev.
Kev nqus thiab kev siv tag nrho ntawm cov tshuaj no nyob ntawm qhov chaw thiab txoj kev ntawm kev coj noj coj ua, nrog rau qhov ntau thiab qhov ntau thiab tsawg ntawm cov khoom tseem ceeb hauv cov tshuaj. Ua kom tau cov tshuaj insulin ntau tshaj plaws ntshav ntshav tshwm sim tom qab 2-18 teev raws li kev tswj hwm ntawm subcutaneous.
Cov tshuaj tsis nkag mus rau hauv kev pom muaj kev sib raug zoo nrog cov ntshav plasma protein, kuaj tau tsuas yog ncig cov tshuaj tiv thaiv kab mob rau insulin. Ntawm metabolism hauv ob peb lub cev insulin yog tsim los ntawm tib neeg cov insulin metabolitesuas yauv mus rau lub cev.
Sab sij huam
Thaum kho nrog cov tshuaj no, xws li tiv thaiv Protafan -Penfill, qhov cuam tshuam tsis zoo yuav tsim, qhov mob hnyav ntawm uas yog nyob ntawm qhov ntau npaum li cas thiab pharmacological kev txiav txim ntawm insulin.
Tshwj xeeb feem ntau, raws li kev mob tshwm sim, hypoglycemia tshwm sim. Yog vim li cas rau nws qhov kev dag pom nyob rau hauv ib qho tseem ceeb tshaj ntawm kev noj ntau npaum li cas ntawm cov tshuaj insulin thiab qhov xav tau ntawm nws. Nyob rau tib lub sijhawm, nws yuav luag tsis tuaj yeem txiav txim siab qhov ntau zaus ntawm nws qhov tshwm sim.
Kev mob ntshav nce siab ntau tuaj yeem nrog txoj kev tsis nco qab, ua kom qaug dab peg, ib ntus lossis tsis zoo ntawm lub hlwb kev ua haujlwm, thiab qee zaum ua rau muaj kev tuag taus.
Ntxiv rau, cov kev mob tshwm sim yog qhov cuam tshuam uas cuam tshuam rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob, poob siab thiab lwm lub.
Nws tsis yog tshem tawm txoj kev loj hlob ntawm anaphylactic kev tshwm sim, cov tsos mob ntawm cov kab mob txo qis, cuam tshuam hauv kev ua haujlwm ntawm lub plab zom mov, angioedema,txog siavlub plawv tsis ua hauj lwm, qis qis ntshav siab thiab yog li ntawd.
Protafan, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)
Cov tshuaj no muab tshuaj subcutaneously. Tib lub sijhawm, nws txoj kev noj tshuaj yog xaiv tau ib tus zuj zus, suav txog tus neeg mob xav tau. Qhov tseeb yog tias cov neeg mob insulin-resistant muaj kev xav tau ntau dua.
Nws tseem yog tus kws kho mob uas txiav txim siab pes tsawg ntawm kev txhaj tshuaj txhua hnub thiab yuav siv cov tshuaj li cas rau kev tiv thaiv kab mob mono- lossis kev sib txuas ua ke, piv txwv li, muaj cov tshuaj insulin, uas tau ua sai lossis luv. Yog tias tsim nyog, kev siv tshuaj insulin ntau ntxiv yog siv cov kev tshem tawm no yog cov tshuaj insulin basal hauv kev sib xyaw nrog cov insulin ceev lossis luv. Txhaj tshuaj feem ntau yog muab raws li cov pluas noj.
Cov neeg mob feem ntau siv Protafan NM subcutaneously ncaj qha rau tus ncej puab. Kev txhaj tshuaj rau hauv phab ntsa plab, pob tw thiab lwm qhov chaw raug tso cai. Qhov tseeb yog tias thaum cov tshuaj raug txhaj rau hauv tus ncej puab, nws nqus tau qeeb dua. Nws nquag pom zoo hloov chaw txhaj tshuaj kom tsis txhob muaj kev txhim kho lipodystrophy.
Dosage thiab txoj kev ntawm cov thawj coj
Protafan yog cov tshuaj ua rau nruab nrab, yog li nws tuaj yeem siv ob leeg sib cais thiab muaj kev sib xyaw nrog cov tshuaj yeeb yaj kiab luv luv, piv txwv li, Actrapid. Dosage yog xaiv ib tus zuj zus. Qhov xav tau txhua hnub rau insulin txawv rau txhua tus neeg mob ntshav qab zib. Nquag, nws yuav tsum los ntawm 0.3 txog 1.0 IU ib kg hauv ib hnub. Nrog kev rog dhau los yog muaj nkauj tiav nraug, muaj peev xwm tiv thaiv insulin kuj yuav loj hlob, yog li qhov yuav tsum tau ua nyob rau txhua hnub. Nrog rau kev hloov pauv hauv txoj kev ua neej, kab mob ntawm cov thyroid caj pas, lub caj pas pituitary, mob siab, thiab lub raum, cov koob tshuaj Protafan NM raug kho raws li tus kheej.
Cov chaw muag tshuaj
Qhov ua rau lub qog ntshav muaj tshwm sim tom qab tawg ntawm insulin thiab nws txoj kev khi rau cov neeg ua haujlwm ntawm cov leeg thiab cov rog ua haujlwm. Cov khoom tseem ceeb:
- txo qis kom ntshav qabzib
- txhim kho kev txhim kho cov piam thaj hauv cov hlwb,
- txhim kho lipogenesis,
- inhibits qhov kev tso tawm ntawm piam thaj los ntawm lub siab.
Tom qab kev coj ua subcutaneous, kev pom tseeb ntawm Protafan insulin cov ntsiab lus siab tshaj 2-18 teev. Qhov pib ntawm kev ua yog tom qab 1.5 teev, qhov siab tshaj plaws tshwm sim tom qab 4-12 teev, tag nrho lub sijhawm yog 24 teev. Hauv cov kev tshawb fawb soj ntsuam, nws tsis tuaj yeem txheeb xyuas carcinogenicity, genotoxicity thiab cuam tshuam txog kev ua haujlwm ntawm kev ua me nyuam, yog li Protafan pom tias yog ib qho tshuaj nyab xeeb.
Cov qauv ntawm Protafan
| Npe | Chaw tsim tshuaj paus |
| Insuman Bazal | Sanofi-Aventis Deutschland GmbH, Lub Teb Chaws Yelemees |
| Br-Insulmidi ChSP | Bryntsalov-A, Russia |
| Humulin NPH | Eli Lilly, Asmeskas |
| Actrafan HM | Novo Nordisk A / O, Denmark |
| Berlinsulin N Basal U-40 thiab Berlisulin N Basal Cwj mem | Berlin-Chemie AG, Lub Tebchaws Yelemees |
| Neej Neeg B | Indar Insulin CJSC, Ukraine |
| Biogulin NPH | Bioroba SA, Brazil |
| Homofan | Pliva, Croatia |
| Isofan Insulin Ntiaj Teb Khob | AI CN Galenika, Yugoslavia |
Hauv qab no yog cov vis dis aus uas hais txog tshuaj isofan insulin-raws li:
Kuv xav ua kuv tus kheej kho kom raug nyob hauv cov yeeb yaj kiab - nws yog txwv tsis pub tswj cov tshuaj insulin ntev ntev!
Kev cuam tshuam nrog lwm yam tshuaj
Cov tshuaj uas ua kom txo qis qhov xav tau ntawm cov tshuaj insulin:
- ACE inhibitors (captopril),
- cov tshuaj tiv thaiv hypoglycemic qhov ncauj,
- MAO monoamine oxidase inhibitors (furazolidone),
- salicylates thiab sulfonamides,
- tsis xaiv-beta-blockers (metoprolol),
- anabolic tshuaj yuam
Cov tshuaj uas ua kom muaj kev xav tau ntxiv rau insulin:
- glucocorticoids (prednisone),
- sympathomimetics
- tshuaj tiv thaiv qhov ncauj
- morphine, glucagon,
- calcium antagonists
- thiazides,
- cov thyroid hormones.
Yuav khaws cov tshuaj insulin li cas?
Cov lus qhia tau hais tias koj tsis tuaj yeem khov cov tshuaj no. Khaws rau hauv qhov chaw txias ntawm qhov kub ntawm 2 txog 8 degrees. Lub raj mis qhib lossis lub taub ntim cov thawv yuav tsum tsis txhob cia rau hauv lub tub yees rau hauv qhov chaw tsaus rau li 6 lub lis piam thaum kub txog 30 degrees.
Qhov kev cuam tshuam tseem ceeb ntawm Protafan thiab nws cov analogues yog muaj qhov siab ntawm qhov kev ua haujlwm 4-6 teev tom qab kev tswj hwm. Vim tias qhov no, tus mob ntshav qab zib yuav tsum tau npaj nws cov khoom noj ua ntej. Yog tias koj tsis noj cov zaub mov hauv lub sijhawm no, cov ntshav qab zib tsawg zuj zus. Nws tuaj yeem siv los ntawm cov poj niam cev xeeb tub thiab menyuam yaus.
Science tsis sawv twj ywm, muaj cov tshiab tsis muaj dab tsi insulins Lantus, Tujeo thiab lwm yam. Yog li no, yav tom ntej txhua leej txhua tus yuav hloov mus rau cov tshuaj tshiab txhawm rau kom txo qis kev pheej hmoo ntawm ntshav qab zib.
Noj ntau dhau
Feem ntau, kev siv tshuaj ntau dhau ntawm insulin ua rau kev txhim kho ntawm lub xeev ntawm cov ntshav ntog ntshav, uas tuaj yeem ua rau txawv txav. Thaum cov mob ntshav qab zib tsawg tshwm sim, tus neeg mob tuaj yeem tshem nws tawm ntawm nws tus kheej los ntawm kev noj cov khoom qab zib. Yog li, ntau tus neeg mob ntshav qab zib nqa ntau yam khoom qab zib nrog lawv: khoom qab zib, khaub noom thiab ntau dua.
Cov mob hnyav tuaj yeem ua rau tsis nco qab. Hauv qhov no, txoj kev kho tshwj xeeb yog ua nrog kev qhia ntawm kev ua haujlwm siab 40% kev daws teeb meem Dextrose lossis Glucagon - intramuscularly, subcutaneously. Thiab tom qab nws rov qab nco qab, tus neeg mob yuav tsum noj cov zaub mov uas muaj carbohydrate tam sim ntawd kom tiv thaiv qhov rov qab txhim kho hypoglycemia thiab lwm cov tsos mob tsis tsim nyog.
Qhia me ntsis
Protafan yog tsim nyob rau hauv lub cev biosynthetic. Cov DNA tsim nyog rau kev tsim tshuaj insulin yog qhia rau cov kab mob poov xab, tom qab ntawd lawv pib tsim cov tshuaj proinsulin. Cov insulin tau tom qab kho cov kab mob enzymatic yog zoo tib yam rau tib neeg. Txhawm rau ntev nws cov kev txiav txim siab, qhov tshuaj tiv thaiv tau nrog cov tshuaj tiv thaiv, thiab lawv tau quaj los siv cov thev naus laus zis tshwj xeeb. Cov tshuaj tsim tawm hauv txoj hauv kev no yog tus cwj pwm tsis tu ncua, koj tuaj yeem paub tseeb tias cov kev hloov pauv hauv lub raj mis yuav tsis cuam tshuam rau cov ntshav qab zib. Rau cov neeg mob, qhov no tseem ceeb: qhov tsawg tshaj qhov cuam tshuam cuam tshuam rau kev ua haujlwm ntawm cov tshuaj insulin, cov nyiaj them zoo dua rau ntshav qab zib yuav yog.
| Kev piav qhia | Protafan, zoo li txhua yam NPH insulins, exfoliates hauv lub vial. Hauv qab no muaj ib qho dawb nag lossis daus, saum toj no - cov kua translucent. Tom qab sib tov, tag nrho kev daws ua tiav xim dawb. Qhov kub siab ntawm cov tshuaj nquag muaj ntawm 100 units hauv ib milliliter. |
| Tso Tawm Cov Ntawv | |
| Muaj pes tsawg leeg | Cov tshuaj ua kom nquag plias yog insulin-isophan, ntu: dej, protamine sulfate kom ntev lub sijhawm ntawm kev nqis tes ua, phenol, metacresol thiab zinc ions ua tshuaj, cov tshuaj rau kho cov kua qaub ntawm kev daws. |
| Nkaus | |
| Cov Khoom Qhia | Mob ntshav qab zib mellitus hauv cov neeg mob xav tau kev kho mob insulin, tsis hais hnub nyoog li cas. Nrog rau hom kab mob 1 - txij li chiv keeb los ntawm cov zaub mov tsis txaus siab, nrog hom 2 - thaum noj tshuaj thiab ntshav qab zib ua tsis tau zoo txaus, thiab glycated hemoglobin ntau tshaj 9%. Mob ntshav qab zib muaj mob ntshav qab zib hauv poj niam cev xeeb tub. |
| Xaiv xaiv | Cov lus qhia tsis muaj qhov tshuaj pom zoo, vim tias yuav tsum tau txhaj tshuaj insulin rau cov ntshav qab zib sib txawv yog qhov sib txawv. Nws suav raws qhov teeb meem ceev ntawm cov ntaub ntawv glycemia. Cov koob tshuaj ntawm cov tshuaj insulin rau yav sawv ntxov thiab yav tsaus ntuj tswj hwm yog xaiv cais - kev suav ntawm cov koob tshuaj insulin rau ob hom. |
| Koob tshuaj hloov kho | |
| Sab sij huam | |
| Cov Yuav Tsum Tau Ua | |
| Cia | Xav tau kev tiv thaiv los ntawm lub teeb, txias txias thiab kub siab (> 30 ° C). Vials yuav tsum khaws cia rau hauv ib lub thawv, tshuaj insulin hauv koob txhaj tshuaj yuav tsum tiv thaiv nrog lub hau. Hauv cov huab cua kub, cov cuab yeej siv txias txias yog siv los thauj Protafan. Cov kev mob zoo rau lub sijhawm ntev (txog 30 lub lis piam) kev khaws cia yog chaw txee lossis lub qhov rooj tub yees. Ntawm chav sov, Protafan hauv pib lub vial kav rau 6 lub lis piam. |
Kev sib txuam
Tus naj npawb ntawm cov tshuaj hypoglycemic, monoamine oxidase inhibitors, angiotensin hloov enzyme thiab carbonic anhydrase, zoo li qee qhov tsis xaiv rau beta-blockers, sulfonamides, Bromocriptineanabolic steroids, tetracyclinesCyclophosphamide,Ketoconazole, Mebendazole,Clofibrate, Pyridoxine, Theophylline, Fenfluramine, cov tshuaj lithium tuaj yeem txhim kho cov nyhuv hypoglycemic ntawm insulin.
Nyob rau tib lub sijhawm, cov tshuaj tiv thaiv qhov ncauj, cov thyroid yuav ua rau nws cov nyhuv hypoglycemic. cov tshuaj hormonesglucocorticosteroids, thiazide diuretics, tricyclic cov tshuaj tiv thaiv kab mob, heparinsympathomimetics Danazolecalcium channel blockers Clonidine, Diazoxide, Phenytoin, Morphine thiab nicotine.
Ua ke nrog Reserpine thiabsalicylates tuaj yeem ua rau ob leeg qaug zog thiab txhim kho cov nyhuv ntawm cov tshuaj no. Qee qhov beta-blockers veil cov tsos mob ntawm kev ua qog ntshav lossis ua rau nws nyuaj rau tshem tawm. Yuav nce lossis txo qis cov tshuaj insulin Octreotide thiabLanreotide.
Lub sijhawm ua
Tus nqi ntawm kev nkag los ntawm Protafan los ntawm cov nqaij mos subcutaneous mus rau hauv cov hlab ntshav hauv cov neeg mob ntshav qab zib yog qhov sib txawv, yog li nws tsis tuaj yeem lees paub meej thaum insulin pib ua haujlwm. Cov ntaub ntawv khaws tseg:
- Los ntawm kev txhaj tshuaj rau cov tsos ntawm cov keeb tshuaj hauv ntshav, ntev li 1.5 teev.
- Protafan muaj qhov ua siab tshaj, nyob hauv cov neeg mob ntshav qab zib feem ntau nws tshwm sim thaum 4 teev txij li lub sijhawm saib xyuas.
- Lub sijhawm tag nrho ntawm qhov kev txiav txim ncav 24 teev. Hauv qhov no, kev vam khom lub sijhawm ntawm kev ua haujlwm ntawm cov koob tshuaj tau ua tiav. Nrog kev qhia txog 10 chav nyob ntawm Protafan insulin, cov txiaj ntsig ntawm cov piam thaj yuav pom nyob rau ntawm 14 teev, 20 units txog li 18 teev.
Kev txhaj tshuaj thim rov qab
Feem ntau rau cov mob ntshav qab zib, txoj kev tswj hwm ob zaug ntawm Protafan tau txaus: thaum sawv ntxov thiab ua ntej yuav mus pw. Kev txhaj tshuaj rau yav tsaus ntuj yuav tsum txaus tswj kom muaj glycemia thawm hmo.
Cov kev xav rau qhov yog:
- qab zib thaum sawv ntxov yog tib yam li thaum yuav mus pw
- Tsis muaj hypoglycemia thaum hmo ntuj.
Feem ntau, cov piam thaj hauv ntshav nce siab tom qab 3 teev sawv ntxov, thaum ntau lawm ntawm cov tshuaj tiv thaiv contrainsular feem ntau nquag, thiab cov nyhuv ntawm cov tshuaj insulin tsis muaj zog. Yog tias Protafan lub ncov xaus xaus, ua rau muaj kev phom sij txog kev noj qab haus huv muaj peev xwm ua tau: tsis nco qab txog qhov muaj ntshav siab thaum hmo ntuj thiab muaj suab thaj ntau thaum sawv ntxov. Txhawm rau zam nws, koj yuav tsum tau saib xyuas cov ntshav qab zib kom tsawg thaum 12 thiab 3 teev. Lub sijhawm ntawm kev txhaj tshuaj rau yav tsaus ntuj tuaj yeem hloov pauv, hloov mus rau cov yam ntxwv ntawm cov tshuaj.
Cov yam ntxwv ntawm kev nqis tes ntawm kev txhaj tshuaj me
Nrog tus mob ntshav qab zib hom 2, mob ntshav qab zib hauv poj niam cev xeeb tub, hauv menyuam yaus, rau cov neeg laus noj zaub mov noj tsis txaus, xav tau NPH insulin kuj yuav tsawg. Nrog rau ib qho tshuaj me me (txog 7 chav nyob), lub sijhawm ua haujlwm ntawm Protafan tuaj yeem raug txwv tsis pub dhau 8 teev. Qhov no txhais tau hais tias ob txoj kev txhaj tshuaj uas muab los ntawm kev qhia yuav tsis txaus, thiab nyob nruab nrab ntawm cov ntshav qab zib yuav nce siab.
Qhov no tuaj yeem zam dhau los ntawm kev txhaj tshuaj Protafan insulin 3 zaug txhua 8 teev: thawj koob tau muab tam sim ntawd tom qab sawv, lub thib ob thaum noj su nrog insulin luv, qhov thib peb, qhov loj tshaj plaws, tsuas yog ua ntej yuav mus pw.
Kev kuaj ntshav qab zib, tsis yog txhua tus ua tiav ua tiav cov txiaj ntsig zoo rau kev mob ntshav qab zib li no. Qee lub sij hawm hmo ntuj nres ua ntej yuav sawv, thiab qab zib thaum sawv ntxov. Ua kom cov koob tshuaj ntau dua ua rau muaj kev noj ntau dua ntawm insulin thiab hypoglycemia. Tib txoj kev tawm ntawm qhov xwm txheej no yog hloov mus rau insulin analogues nrog lub sijhawm ua haujlwm ntev.
Kev quav zaub mov
Tus mob ntshav qab zib rau kev kho mob insulin feem ntau yog hais txog cov tshuaj insulin nruab nrab thiab luv. Lub sijhawm luv luv yog qhov xav tau kom qis cov piam thaj hauv cov ntshav uas nkag los ntawm cov zaub mov. Nws kuj tseem siv los kho glycemia. Ua ke nrog Protafan, nws yog qhov zoo dua los siv luv luv npaj ntawm tib lub chaw tsim khoom - Actrapid, uas tseem muaj nyob hauv vials thiab cartridges rau koob txhaj tshuaj.
Lub sijhawm ntawm kev tswj hwm ntawm insulin Protafan tsis yog nyob ntawm kev noj mov ntawm ib txoj kev twg, kwv yees li ntawm kev sib xyaw ntawm kev txhaj tshuaj yog qhov txaus. Thaum koj tau xaiv lub sijhawm yooj yim, koj yuav tsum ua raws li nws tas li. Yog tias nws txuam nrog cov zaub mov, Protafan tuaj yeem muab luv nrog insulin luv. Nyob rau tib lub sijhawm nws nyob hauv tib lub koob txhaj tshuaj yog qhov tsis zoo, vim tias nws zoo li yuav ua txhaum nrog koob tshuaj thiab maj mam nqis tes ua ntawm qhov luv luv.
Qhov siab tshaj plaws
Ntawm ntshav qab zib mellitus, koj yuav tsum tau txhaj tshuaj insulin ntau npaum li qhov yuav tsum tau ua kom qab ntxiv ntawm cov piam thaj. Cov lus qhia rau kev siv tsis tau teeb tsa qhov ntau tshaj plaws. Yog tias cov nyiaj ntawm Protafan insulin raug ntau lawm, qhov no yuav qhia tau cov tshuaj insulin tsis kam. Nrog rau cov teeb meem no, koj yuav tsum sab laj nrog koj tus kws kho mob. Yog tias tsim nyog, nws yuav muab tshuaj rau noj uas txhim kho kev ua ntawm cov tshuaj hormones.
Cev xeeb tub Siv
Yog tias mob ntshav qab zib gestational nws tsis tuaj yeem ua tiav glycemia ib leeg los ntawm kev noj haus, cov neeg mob tau kho cov tshuaj insulin. Cov tshuaj thiab nws cov koob tshuaj tau xaiv tshwj xeeb, vim tias ob qho tib si hypo- thiab hyperglycemia nce qhov kev pheej hmoo ntawm kev ua tsis tiav hauv tus menyuam. Cov tshuaj Insulin Protafan raug tso cai siv thaum cev xeeb tub, tab sis feem ntau, cov tshuaj ntev yuav zoo dua.
Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva
Kuv tau kawm mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.
Kuv maj nrawm los qhia txoj xov zoo - Endocrinology Qhov Chaw Tshawb Xyuas Kev Tshawb Fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov ntshav qab zib kom meej. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.
Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib mus txog lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!
Yog tias cev xeeb tub tshwm sim nrog tus mob ntshav qab zib hom 1, thiab tus poj niam ua tiav tau txiaj ntsig ntawm tus kab mob Protafan, kev hloov pauv ntawm cov tshuaj tsis tas yuav tsum tau.
Kev pub mis niam tau zoo nrog kev kho mob insulin. Protafan yuav tsis ua mob rau tus menyuam txoj kev noj qab haus huv. Cov tshuaj Insulin nkag mus rau hauv cov mis hauv qhov ntau thiab tsawg, tom qab ntawd nws tau tawg hauv cov hnyuv ntawm tus menyuam, ib yam li lwm cov protein.
Kev phiv tshuaj
Ib qho kev phiv rau txoj kev kho yog hypoglycemia. Nws tuaj yeem tshwm sim thaum cov koob tau tshaj tus neeg mob xav tau cov tshuaj insulin. Raws li kev tshawb fawb soj ntsuam, nrog rau cov ntaub ntawv hais txog kev siv tshuaj tom qab nws tso tawm ntawm lub lag luam, qhov kev pheej hmoo ntawm hypoglycemia sib txawv hauv cov pab pawg sib txawv ntawm cov neeg mob, nrog ntau cov tshuaj sib txawv thiab qib glycemic tswj.
Thaum pib ntawm kev siv tshuaj insulin, qhov tsis zoo ntawm lub ntsej muag, cov kab mob thiab cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj (mob, liab, urticaria, mob, doog, o thiab khaus ntawm qhov chaw txhaj tshuaj) tuaj yeem pom. Cov kev tsis haum no feem ntau yog ua dhau. Kev txhim kho sai hauv cov ntshav qabzib tswj ntshav tuaj yeem ua rau lub xeev rov qab ua haujlwm ntawm qhov mob tsis muaj mob neuropathy. Lub sij hawm ntev tsim tau zoo glycemic tswj txo qhov kev pheej hmoo ntawm kev muaj mob ntawm cov ntshav qab zib retinopathy. Txawm li cas los xij, kev sib zog ntawm kev siv tshuaj insulin kom sai txhim kho glycemic tswj tuaj yeem ua rau ib ntus exacerbation ntawm tus mob ntshav qab zib retinopathy.
Raws li kev tshawb fawb hauv chav kho mob, cov hauv qab no yog cov kev phiv tshuaj uas yog cais raws zaus thiab kab ke hauv chav kawm raws li MedDRA.
Raws li qhov muaj ntau zaus tshwm sim, cov kev tawm tsam no tau muab faib ua cov uas muaj ntau zaus (/1 / 10), feem ntau (≥1 / 100 txog 1/1000 txog 1/10000 txog ® NM Penfil ® lub sijhawm pub niam mis kuj tsis muaj, vim kev kho tus niam tsis muaj kev phom sij rau tus menyuam. Txawm li cas los xij, nws yuav tsim nyog kho qhov tshuaj thiab zaub mov noj rau leej niam.
Kev npaj rau biosynthetic tib neeg cov tshuaj insulin yog qhov muaj txiaj ntsig zoo thiab muaj kev nyab xeeb rau kev kho mob ntshav qab zib hauv cov menyuam yaus thiab cov hluas ntawm cov hnub nyoog sib txawv. Kev xav tau insulin txhua hnub hauv cov menyuam yaus thiab cov hluas nyob ntawm theem ntawm tus kabmob, lub cev lub cev, hnub nyoog, kev noj zaub mov zoo, kev tawm dag zog, qib ntawm insulin tsis kam thiab qhov zoo ntawm qib glycemia.
Daim ntawv thov nta
Noj tshuaj kom tsis txaus los sis tsis txuas kev kho mob (tshwj xeeb tshaj yog muaj ntshav qab zib hom I) tuaj yeem ua rau hyperglycemia Cov. Feem ntau, thawj cov tsos mob ntawm hyperglycemia pib maj mam dhau ob peb teev lossis hnub. Lawv suav nrog nqhis dej, tso zis tsis tu ncua, xeev ntuav, ntuav, nkees, liab thiab daj ntawm daim tawv nqaij, qhov ncauj qhuav, tsis qab los noj mov, thiab tsis hnov ntxhiab ntawm cov acetone hauv cov pa tawm.
Hauv cov ntshav qab zib hom I, hyperglycemia, uas tsis kho, ua rau ketoacidosis uas mob ntshav qab zib, uas ua rau muaj kev tuag taus.
Kev ntshav siab tej zaum yuav tshwm sim nrog kev txhaj tshuaj ntau heev rau kev xav tau cov tshuaj insulin.
Noj zaub mov tsis zoo lossis ua kom lub cev tsis muaj zog ua rau lub cev ntuag ntshav qab zib.
Cov neeg mob uas tau txais kev tswjhwm zoo tshaj plaws ntawm cov ntshav qabzib ntau vim kev siv tshuaj insulin ntau ntxiv tuaj yeem paub txog qhov hloov pauv ntawm lawv cov tsos mob ib txwm muaj, cov mob ntshav sai ua ntej, uas yuav tsum ceeb toom ua ntej.
Cov paib ceeb toom ib txwm yuav ploj hauv cov neeg mob uas mob ntshav qab zib ntev.
Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis hom insulin tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Kev hloov pauv ntawm cov kev xav, hom (chaw tsim khoom), hom, keeb kwm ntawm cov kua dej (tib neeg lossis kev sib piv ntawm tib neeg cov insulin) thiab / lossis cov txheej txheem ntau lawm yuav tsum tau tsim kho cov tshuaj insulin. Cov neeg mob uas pauv mus rau Protafan ® NM Penfil ® uas muaj cov tshuaj insulin sib txawv tuaj yeem xav tau ntau ntxiv los ntawm kev txhaj tshuaj txhua hnub lossis hloov pauv ntau npaum li piv rau cov tshuaj insulin uas lawv ib txwm siv. Qhov kev xav tau ntawm kev xaiv koob tshuaj yuav tshwm sim ob qho tib si hauv thawj zaug kev siv tshuaj tshiab, thiab nyob rau thawj ob peb lub lis piam lossis lub hlis ntawm kev siv.
Thaum siv cov tshuaj insulin, cov tshuaj tiv thaiv tuaj yeem tshwm sim ntawm qhov chaw txhaj tshuaj, uas yuav suav nrog qhov mob, liab liab, khaus, ua xua, o, o tuaj thiab o. Hloov pauv ntawm qhov chaw txhaj tshuaj hauv ib qho chaw tuaj yeem txo lossis tiv thaiv cov kev tsis haum no. Cov kev tawm tsam feem ntau yuav ploj mus tom qab ob peb hnub lossis vas thiv. Tsis tshua muaj tshwm sim, kev tawm tsam ntawm thaj chaw txhaj tshuaj tej zaum yuav tsum tsis muaj kev kho mob nrog Protafan ® NM Penfil ®.
Ua ntej taug kev nrog kev hloov chaw ntawm lub sijhawm, cov neeg mob yuav tsum sab laj nrog tus kws kho mob, vim tias qhov no hloov lub sijhawm ntawm cov tshuaj insulin thiab kev noj zaub mov.
Insulin kev ncua yuav tsum tsis txhob siv cov tshuaj insulin twj rau lub caij nyoog ntev ua haujlwm ntawm insulin.
Kev sib xyaw ntawm thiazolidinediones thiab cov tshuaj insulin
Thaum thiazolidinediones siv nrog kev siv tshuaj insulin, cov mob ntawm lub plawv tsis ua haujlwm tau tshaj tawm, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev pheej hmoo rau txoj kev tsis ua haujlwm txhawm rau lub siab. Qhov no yuav tsum tau txiav txim siab thaum sau ntawv kho mob nrog kev sib xyaw ntawm thiazolidinediones nrog insulin. Nrog kev siv cov tshuaj no ua ke, cov neeg mob yuav tsum tau saib xyuas los ntawm kws kho mob rau kev txhim kho cov cim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm hnyav, hnyav ntxiv thiab tshwm sim ntawm edema. Yog tias lub cev tsis zoo hauv lub siab ua haujlwm, kho nrog thiazolidinediones yuav tsum tsis ua mus ntxiv.
Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem
Tus neeg mob cov lus teb thiab nws lub peev xwm los mloog zoo yuav ua rau lub plawv tsis muaj ntshav qab zib. Qhov no tuaj yeem ua rau muaj kev pheej hmoo hauv cov xwm txheej uas cov peev xwm no muaj qhov tshwj xeeb tseem ceeb (piv txwv, thaum tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem).
Cov neeg mob yuav tsum qhia rau lawv kom ntsuas los tiv thaiv kom tsis txhob muaj ntshav qab zib ua ntej tsav tsheb. Qhov no yog qhov tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj zog lossis tsis muaj cov tsos mob tshwm sim ua ntej ntawm lub qog ntshav ntshav lossis lub sijhawm ntog ntshav siab tsis tshua tshwm sim ntau zaus. Thaum muaj teeb meem li no, qhov tsim nyog ntawm kev tsav tsheb yuav tsum ntsuas.
Qhov sib txawv ntawm cov tshuaj insulin
Cov tshuaj insulin ntev ntev, xws li Lantus thiab Tujeo, tsis muaj lub ncov siab, zoo dua kev zam thiab tsis tshua muaj kev ua xua. Yog tias tus mob ntshav qab zib tsis muaj qhov ntshav qab zib qis los yog ntshav qab zib vim tsis muaj qhov pom tseeb, Protafan yuav tsum tau hloov nrog cov tshuaj insulins ntev niaj hnub no.
Lawv qhov kev tsis txaus ntseeg tseem ceeb yog lawv tus nqi siab. Tus nqi ntawm Protafan yog li 400 rubles. rau ib lub raj mis thiab 950 rau packing cartridges rau syringe cwjmem. Insulin analogues yuav luag 3 zaug kim kim.
Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv nws. nyeem ntxiv >>
Lub cev ua tau yooj yim
qhov kev tshem tawm dawb, nyob rau hauv uas muaj qee lub cev dawb thiab xim tsis tshua muaj xim lossis yuav luag tsis muaj xim zoo nkauj tau tsim thaum sawv ntsug, qhov nag lossis daus tau yooj yim nrog rov qab zoo dua. Thaum kuaj pom nyob rau hauv lub tshuab tsom kab, cov khoom me me zoo li muaju ntawm cov duab ntev, qhov ntev ntawm cov muaju feem ntau yog 1-20 microns.
Cia rau cov neeg mob
Khaws rau hauv tub yees ntawm qhov kub ntawm 2 ° C - 8 ° C. Tsis txhob khov.
Khaws cov khoom lag luam hauv cov ntawv ntim thib ob rau kev tiv thaiv los ntawm kev cuam tshuam ntawm lub teeb.
Tom qab qhib: siv li ntawm 6 lub lis piam. Tsis txhob muab cia rau hauv tub yees. Khaws ntawm qhov kub tsis tshaj li 30 ° C.
Tsis txhob siv tom qab hnub tas sij hawm luam tawm ntawm pob.
Khaws tsis ncav cuag ntawm cov menyuam yaus.
Lub khob iav (hom 1) nrog lub peev xwm ntawm 3 ml, uas yog roj hmab piston (bromobutyl roj hmab) thiab kaw nrog lub taub roj hmab (cov roj hmab bromobutyl / polyisoprene). Daim cartridge muaj ib lub khob iav rau kev sib tov. 5 cartridges rau ib lub thawv.
Cov yam ntxwv ntawm cov tshuaj
Cov tshuaj yog ncua kev qhia hauv qab daim tawv nqaij.
Pawg, cov khoom uas nquag:
Isulin insulin-tib neeg semisynthetis (tib neeg semisynthetic). Nws muaj lub sijhawm ua haujlwm nruab nrab. Protafan NM yog contraindicated nyob rau hauv: insulinoma, hypoglycemia thiab hypersensitivity rau yam tshuaj nquag.
Yuav noj li cas thiab haus li cas?
Cov tshuaj insulin raug txhaj ib zaug lossis ob zaug ib hnub, ib nrab teev ua ntej noj tshais. Hauv qhov no, qhov twg yuav tau txhaj tshuaj, nws yuav tsum tau hloov tas li.
Cov koob tshuaj yuav tsum tau xaiv rau txhua tus neeg mob ib tus zuj zus. Nws qhov ntim nyob ntawm seb cov piam thaj hauv cov zis thiab ntshav txaus, ntxiv rau qhov yam ntxwv ntawm chav kawm ntawm tus kab mob. Yeej, qhov tshuaj yog muab 1 lub sijhawm toj ib hnub thiab yog 8-24 IU.
Hauv cov menyuam yaus thiab cov neeg laus uas muaj lub siab tsis txaus siab rau insulin, qhov koob tshuaj tau raug txo mus rau 8 IU ib hnub. Thiab rau cov neeg mob uas tsis tshua muaj siab zoo, tus kws kho mob koom nrog yuav muab tshuaj ntau dua 24 IU nyob rau ib hnub. Yog tias qhov koob tshuaj txhua hnub ntau dua li 0.6 IU rau ib kg, tom qab ntawd cov tshuaj raug muab los ntawm ob qhov kev txhaj tshuaj, uas tau ua nyob hauv ntau qhov chaw.
Cov neeg mob uas tau txais 100 IU lossis ntau dua toj ib hnub, thaum hloov cov tshuaj insulin, yuav tsum tau saib xyuas tas li los ntawm cov kws kho mob. Hloov cov tshuaj nrog rau lwm qhov yuav tsum tau ua nrog kev soj ntsuam tsis tu ncua ntawm cov piam thaj hauv ntshav.
Yuav kho tus overdose li cas?
Yog hais tias tus neeg mob nyob rau hauv lub xeev meej pem, ces tus kws kho mob tau sau ntawv dextrose, uas tau muab tshuaj los ntawm lub cev nqus dej, mob intramuscularly lossis leeg ntshav. Glucagon lossis hypertonic dextrose kev daws teeb meem tseem tau muab tshuaj ntxiv ib leeg.
Thaum raug ntawm kev txhim kho lub qog ua pa tsis tsaug zog, 20 txog 40 ml, i.e. 40% dextrose kev daws teeb meem kom txog rau thaum tus neeg mob tawm ntawm qhov tsis nco qab.
- Ua ntej koj siv cov tshuaj insulin los ntawm pob, koj yuav tsum xyuas tias cov tshuaj hauv lub raj mis muaj cov xim pob tshab. Yog tias clouding, nag lossis daus los yog lub cev txawv teb chaws pom, kev daws teeb meem raug txwv.
- Qhov kub ntawm cov tshuaj ua ntej kev tswj hwm yuav tsum yog chav kub.
- Thaum muaj kev kis mob, ua haujlwm ntawm lub qog ua haujlwm tsis zoo, Addiosn tus kab mob, mob raum tsis ua haujlwm, mob hypopituitarisis, nrog rau cov neeg mob ntshav qab zib thaum lub hnub nyoog laus, cov koob tshuaj insulin yuav tsum tau kho tus kheej.
Cov laj thawj ntawm kev ua ntshav siab tuaj yeem yog:
- noj ntau dhau
- ntuav
- tshuaj hloov
- cov kab mob uas txo qis qhov xav tau ntawm insulin (mob siab thiab mob raum, hypofunction ntawm cov thyroid caj pas, lub caj pas pituitary, adrenal cortex),
- tsis-saib ntawm kev noj zaub mov,
- cuam tshuam nrog lwm yam tshuaj
- zawv plab
- lub cev overvoltage,
- hloov chaw txhaj tshuaj.
Thaum hloov ib tus neeg mob los ntawm tsiaj cov tshuaj insulin rau tib neeg cov insulin, ib qho kev txo qis hauv cov ntshav qab zib yuav tshwm sim. Kev hloov mus rau tib neeg cov kua dej yuav tsum tau ua raws li kev kho mob, thiab nws yuav tsum tau ua raws li kev saib xyuas nruj ntawm kws kho mob.
Thaum lub sijhawm thiab tom qab yug menyuam, xav tau cov tshuaj insulin tuaj yeem txo qis. Thaum lub sijhawm lactation, koj yuav tsum saib xyuas koj niam ntau lub hlis, kom txog thaum xav tau cov tshuaj insulin.
Ib qho kev xav ua ntej rau kev nce qib ntawm cov ntshav qog tuaj yeem ua rau tsis zoo rau lub peev xwm ntawm tus neeg mob tsav tsheb thiab tswj kev txhim kho thiab cov tshuab thiab tshuab.
Los ntawm kev noj qab zib lossis cov khoom noj uas muaj cov khoom noj uas muaj carbohydrates, cov neeg mob ntshav qab zib tuaj yeem nres tsis muaj ntshav qab zib tsawg. Nws raug nquahu tias tus neeg mob ib txwm muaj tsawg kawg 20 g suab thaj nrog nws.
Yog tias txo lub qog ntshav qab zib tau raug ncua, nws yog qhov yuav tsum tau ceeb toom rau tus kws kho mob uas yuav kho qhov hloov kho.
Thaum cev xeeb tub, qhov yuav tsum tau txo qis (1 hlis) lossis nce ntxiv (2-3 trimesters) ntawm lub cev xav tau cov tshuaj insulin yuav tsum raug txiav txim siab.
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Cov lus qhia Venosmin rau kev siv, nqe, tshuaj xyuas, cov kab mob sib piv ntawm cov tshuaj
Cov tshuaj Venosmin: cov lus qhia rau kev Siv Hnyav nyob rau hauv ob txhais ceg, kab laug sab veins lossis varicose leeg - ib tug phooj ywg ntau ntawm cov neeg niaj hnub. Yog tias muaj cov tsos mob tshwm sim, tsis txhob tawm hauv cov cim. ... -
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