Zokor forte ntsiav tshuaj: tus neeg mob tshuaj xyuas thiab ntsuas rau kev siv

Muaj cov qauv hauv cov ntsiav tshuaj, uas tau coated. 10 mg ntsiav tshuaj simvastatin, muaj lub teeb xim liab dawb, oval duab zoo ntawm ib sab, ntawm qhov muaj txua ntxiv "MSD 735«.

20 mg ntsiav tshuaj simvastatinmuaj daj-xim av xim, oval tus duab zoo nyob rau hauv ib tes, ntawm lwm tus muaj engraving "MSD 740«.

Zokor Forte yog muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj liab, muaj ib tug kheej li tus kheej zoo nyob rau hauv ib tes, nyob rau lwm yam muaj yog engraving "MSD 749«.

Cov hlwv qhwv muaj 14 ntsiav tshuaj, hauv lub thawv muaj ib los yog ob qhov hlwv.

Pharmacological kev txiav txim

Cov tshuaj muaj cov lus tshaj tawm hypolipidemic. Cov ntsiav tshuaj muaj cov khoom xyaw nquag simvastatin, nyob rau hauv tus txheej txheem ntawm hydrolysis tig mus ua cov khoom sib txuas. Lub cev hluav taws xob ntawm simvastatin inhibits qhov enzyme HMG-CoA reductase. Qhov enzyme no yuav siv sijhawm thawj zaug ntawm biosynthesis. roj.

Yog li ntawd, nyob rau hauv kev cuam tshuam ntawm Zokor, qib ntawm cov cholesterol nyob rau hauv lub cev yog kom meej meej txo, nrog rau cov ntsiab lus ntawm cov roj cholesterol, uas cuam tshuam nrog cov lipoproteins uas tsis muaj ntau thiab tsawg. Plasma cov ntsiab lus ntshav ntawm triglycerides tseem txo.

Tib lub sijhawm, thaum noj simvastatin, qib ntawm cov roj cholesterol, uas cuam tshuam nrog cov lipoproteins ntau ntom, yog qhov nce ntxiv.

Qhov ua tau zoo ntawm cov tshuaj nrog ntau hom sib txawv yog sau tseg. hyperlipidemia, nyob rau hauv kev nrog heterozygous, tsev neeg, tsis-tsev neeg. Tsis tas li, cov tshuaj muaj txiaj ntsig ntawm kev sib xyaw ntawm hyperlipidemia nyob rau hauv qhov xwm txheej ntawd cov pluas noj tsis txaus kom normalize ntshav plasma lipids.

Qhov ntau npaum li cas ntawm cov lipids hauv ntshav txo tau 14 hnub tom qab pib kev kho mob. Hauv qhov no, tus nqi ntau tshaj yog pom thaum 4-6 lub lim tiam ntawm kev kho mob. Ntxiv mus, thaum noj cov tshuaj, cov txiaj ntsig no tau txais kev cawmdim.

Tom qab txoj kev kho mob tiav, maj mam qhov ntsuas ntawm tag nrho cov roj hauv plasma rov qab rau thawj qhov tseem ceeb, uas tau sau tseg ua ntej noj cov tshuaj.

Pharmacokinetics thiab cov chaw muag tshuaj

Qhov siab tshaj plaws ntawm simvastatin metabolites hauv cov ntshav tau sau tseg 1.3-2.4 teev tom qab ib tus neeg tau noj ib koob ntawm cov tshuaj. Kwv yees li 85% ntawm simvastatin noj ntawm qhov ncauj yog nqus rau hauv lub cev.

Tom qab kev tswj hwm sab hauv, piv nrog lwm cov ntaub so ntswg, qhov siab dua ntawm cov tshuaj nquag raug sau tseg hauv daim siab.

Thaum lub sijhawm tso thawj los ntawm cov hlab ntsha hauv lub siab, simvastatin yog metabolized, tom qab ntawd cov tshuaj thiab nws cov metabolites yog tawm ntawm lub cev nrog cov kua tsib.

Noj zaub mov tam sim ntawd tom qab noj cov tshuaj tsis txhaum tus pharmacokinetics ntawm cov tshuaj. Nrog kev kho mob ntev, simvastatin tsis sib sau hauv cov nqaij hauv lub cev.

Kev ntsuas rau siv

Kev siv Zokor yog qhia rau cov neeg uas koom nrog ib pab pawg uas muaj qhov pheej hmoo ntawm txoj kev loj hlob mob plawv plawv hais txog ntawm cov ntshav. Cov pab pawg muaj xws li cov neeg uas muaj cov teeb meem hauv qab no:

cerebrovascular pathologies, suav nrog mob stroke(keeb kwm)
mob ntshav qab zib mellitus(cov tshuaj muaj peev xwm tiv thaiv qhov tshwm sim ntawm qhov pheej mob vascular thiab txo qhov kev xav tau kom rov ua haujlwm thiab txiav tawm ntawm qhov qis qis),
pathology ntawm peripheral ntshav txaus.

Cov tshuaj yog siv rau hauv kev kho mob ntawm cov neeg uas muaj mob ntawm kev mob plawv thiab cov neeg mob hypercholesterolemia. Hauv qhov no, Zokor tuaj yeem tiv thaiv qhov pom ntawm atherosclerotic vascular txhab hauv plawv, kev txhim kho ntawm lwm cov kev mob hnyav.

Zokor tseem tseem muaj kev kho mob rau cov neeg mob laus hauv cov xwm txheej no:

cov neeg nrog theem siab ntawm kev dav dav roj, apolipoprotein Bntxiv rau cov roj (cholesterol), uas cuam tshuam nrog cov roj lipoproteins tsawg tsawg, txuam nrog kev noj haus,
nrog hypertriglyceridemia,
nrog cov roj (cholesterol) tsawg ntawm cov lipoproteins uas muaj ntau ntau, uas cuam tshuam nrog thawj hypercholesterolemia thaum ua kom lub cev noj haus,
nrog homozygous tsev neeg daim ntawv ntawm hypercholesterolemia nyob rau hauv parallel nrog lwm txoj kev kho mob thiab kev noj haus.

Cov Yuav Tsum Muaj

Tsis pom zoo rau kev siv Zokor yog:

tsis hnov lus haum thiab metabolism ntawm lactose,
mob siab tiv thaiv kab mob siab, ib qho tseem ceeb thiab nce ntxiv hauv tus naj npawb ntawm transaminases ntawm cov tsis paub keeb kwm,
ib tug neeg intoleranceb
cev xeeb tub thiab pub mis ntuj,
hnub nyoog txog 10 xyoo.

Tus txheeb ze sib cog lus rau kev siv Zokor yog:

Hauv cov xwm txheej zoo li no, cov tshuaj tau tawm nrog ceev faj.

Tsuas tshuaj thiab cov thawj coj Zokor forte

Ua ntej thiab thaum kawg ntawm kev kho, kev noj zaub mov hypocholesterol yuav tsum ua raws cai. Sab hauv, hauv qhov pib txhaj tshuaj 10 mg ib zaug, thaum yav tsaus ntuj, nrog mob sib khuav lossis cov qib mob hypercholesterolemia qhov hno thawj zaug yog 5 mg, yog tias tsim nyog, qhov koob tshuaj yog maj mam nce nyob rau ncua sij hawm ntawm 4 lub lis piam. Nrog tsev neeg homozygous hypercholesterolemia koob tshuaj txhua hnub - 40 mg ib zaug, yav tsaus ntuj lossis 80 mg / hnub (faib rau 3 koob - 20 mg thaum sawv ntxov, 20 mg thaum tav su, 40 mg thaum yav tsaus ntuj). Nrog rau cov kab mob plawv qhov pib koob tshuaj yog 20 mg, ib zaug, thaum yav tsaus ntuj, yog tias tsim nyog, nws yog maj mam nce ntawm ncua sijhawm ntawm 4 lub lis piam mus rau 80 mg.

Sab sij huam Zokor forte

Mob taub hau, kiv taub hau, mob asthenia, dyspepsia, mob siab / daj ntseg, mob caj dab, mob leeg, mob leeg nqaij, myalgia, mob rwj, mob rwj rau lub cev, mob caj dab, mob hlab ntsha hlwb, ntshav liab, alopecia, tawv nqaij daj, mob caj dab, mob caj dab, ua rau lub cev ua kom tawv nqaij , ua tsis taus pa luv, dav dav malaise, angioedema, lupus-zoo li syndrome, polymyalgia rheumatism, mob vasculitis, mob caj dab, arthralgia, nce ESR, thrombocytopenia, eosinophilia), kev kuaj ntshav tsis xws luag (nce qib ntawm trans hu ua alkaline phosphatase, gamma-glutamyltranspeptidase, pob txha pob txha creatine phosphokinase, kev hloov pauv hauv daim siab ua haujlwm kuaj).

Hauv ntau qhov muaj mob paub ntau tshaj plaws ntawm kev siv ntau tshaj (ntau kawg noj - 450 mg), tsis muaj cov tsos mob tshwj xeeb los yog muaj tej yam tshwm sim. Kev kho mob Symptomatic yog siv.

Potentiates muaj txiaj ntsig ntawm cov txiaj ntsig ntawm coumarin anticoagulants. Thaum ua ke nrog cyclosporine, itraconazole, ketoconazole, fibric acid derivatives, niacin, erythromycin, clarithromycin, protease inhibitors, nefazodone, kev pheej hmoo ntawm rhabdomyolysis nce. Kev kho mob yuav tsum tsis ua mus ntxiv yog tias qhov mob myopathy paub tseeb lossis xav tias tsam muaj.

Ua ntej pib kev kho mob, nws raug nquahu kom coj los ua (thiab tom qab ntawd rov ua ntu zus tas) kev kawm txog lub siab ua haujlwm. Thaum cov theem ntawm kev hloov tsheb yuav pib dhau qhov kev cai siab ntawm ciam teb los ntawm 3 zaug, cov tshuaj ua haujlwm raug muab tso tseg. Nws yog ntawv ceeb toom nrog ceev faj rau cov neeg mob uas quav cawv thiab / lossis muaj keeb kwm muaj kab mob siab.

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Koj tuaj yeem xav txog cov analogues ntawm Zokor forte hauv cov qeb muaj feem, ob qho pheej yig dua thiab kim dua:

Cov tshuaj ntsuab no tau koom nrog pab pawg "Atherosclerosis". Tsis tas li nyob hauv pab pawg no suav nrog: Dipromonium, Brilinta, Benzaflavin

Cov cuab yeej no zwm rau pab pawg ntawm "kab mob cerebrovascular." Tsis tas li nyob hauv pab pawg no suav nrog: Actovegin mloog zoo, NICOTINIC ACID-VIAL, Kapilar

Sab sij huam

Cov kev mob tshwm sim no yuav tshwm sim thaum kho cov neeg mob nrog Zokor:

kev tsis xis nyob thiab mob hauv plab, tsam plab, tso quav, tso quav,
mob taub hau zoo nkaus ntawm kev ua kom tsis muaj zog anemia,
kiv taub haucramps peripheral neuropathy, paresthesianco thiab pw tsaug zog,
daim tawv nqaij ua pob, alopecia, khaus.

Nyob rau hauv tsawg zaus, tsim mob hlwb, rhabdomyolysisnyob rau hauv tus txheej txheem ntawm kev noj simvastatin, nrog rau kev txo qis kev ua haujlwm hauv daim siab. Cov xwm txheej ntawm kev txhim kho ntawm myalgia tau sau tseg. Feem ntau, Zokor pom zoo los ntawm cov neeg mob.

Nrog rau qhov ua kom tsis haum rau qhov tshuaj, Quincke's edema, vasculitis yuav tshwm sim dermatomyositisthrombocytopenia, eosinophilia, mob caj dab, ESR nce ntxiv, arthralgia thiab lwm tus

Cov lus qhia rau kev siv Zokora (Txujci thiab ntau npaum li cas)

Cov lus qhia rau kev siv Zokora qhia tias tus neeg mob noj tshuaj noj ntawm ncauj, tsis hais noj mov. Qhov tshuaj txhua hnub ntawm cov tshuaj yuav tsum tau noj thaum yav tsaus ntuj, tsis tas yuav faib nws rau hauv ntau koob.

Qhov nruab nrab koob tshuaj simvastatin ib hnub yog 5-80 mg. Ntau tshaj 80 mg ntawm simvastatin tauj ib hnub yuav tsum tsis txhob noj.

Tus kws kho mob xaiv cov koob tshuaj, thaum lub sijhawm ib txwm coj mus rau hauv tus lej qib ntawm lipids hauv cov ntshav. Cov koob tshuaj tau hloov kho tsis ntau tshaj ib zaug txhua 4 asthiv.

Rau lub hom phiaj ntawm kev tiv thaiv thiab kev kho mob Ischemic mob plawv tawm tsam cov keeb kwm yav dhau los ntawm kev noj haus, ib koob tshuaj txhua hnub ntawm 40 mg ntawm simvastatin yog pib kho.

Ntawm hypercholesterolemiayog tias qhov kev noj zaub mov noj tsis zoo rau qhov tshwm sim uas xav tau, qhov tshuaj txhua hnub ntawm 20 mg ntawm simvastatin ib hnub yog tsim los. Yog tias cov plasma lipid cov ntsiab lus xav tau kom tsawg dua 45% lossis ntau dua, kev siv tshuaj rau ib hnub yuav tsum yog 40 mg.

Yog tias tus neeg mob muajCov mob nyhav lossis mob me ntawm hypercholesterolemia, tom qab ntawd cov koob tshuaj nyob rau ib hnub tuaj yeem txo mus rau 10 mg.

Tus kws kho mob txiav txim siab qhov tsim nyog ntawm cov tshuaj, ua ntej ntsuas cov qib ntawm lipids thiab saib xyuas qhov ua tau zoo ntawm cov tshuaj tom qab pib txoj kev kho. Yog tias 4 lub lis piam tom qab pib kho, qhov pom tshwm sim yuav tsis pom, qhov no, qhov kev siv tshuaj ntau ntxiv, tab sis maj mam, kom txog thaum muaj cov txiaj ntsig tawm hais.

Ntawm homozygous tsev neeg hypercholesterolemia tawm tsam keeb kwm ntawm kev noj zaub mov noj thiab lwm txoj kev kho mob, qhov pib siv ntawm Zokor yuav tsum yog 40 mg rau ib hnub, lossis 80 mg ntawm simvastatin tau sau tseg nrog cov xwm txheej uas 20 mg ntawm cov tshuaj noj thaum tav su thiab 40 mg thaum yav tsaus ntuj.

Cov neeg hluas nrog homozygous tsev neeg hypercholesterolemia yog pib kho 10 mg ntawm cov tshuaj ib hnub. Kev siv tshuaj ntau tshaj txhua hnub rau cov hluas yog 40 mg.

Kev sib txuam

Tshaj tawm cov txiaj ntsig tau zoo yog pom nrog kev kho mob kom zoo ib yam Zokor thiab cov kab tsib hauv cov kua tsib.

Nrog rau kev tswj hwm tib lub sij hawm ntawm fibrates, cyclosporine thiab lipid-txo cov koob tshuaj ntawm niacin ib hnub, koj tuaj yeem noj tsis tshaj 10 mg ntawm cov tshuaj Zokor.

Cov neeg tau txais Verapamil thiab Amiodaroneyuav tsum tsis txhob haus ntau tshaj 20 mg ntawm simvastatin ib hnub.

Simvastatin tsis ua raws li qhov kev ua ntawm enzymatic ntawm CYP3 A4.

Nrog rau kev tswj hwm ua ke ntawm cov tshuaj uas sim ua kom muaj kev cuam tshuam ntawm CYP3 A4, kev muaj peev xwm ntawm kev txhim kho myopathy thiab rhabdomyolysis nyob rau hauv cov uas noj cov simvastatin ntau ntxiv. Nws yog ib qho tsim nyog yuav tsum tsis txhob muab Zokor coj los ua ke nrog itraconazole, Erythromycin, nefazodone, ketoconazole, telithromycin.

Qhov ntxim nyiam ntawm kev tsim myopathy thiab rhabdomyolysis nce thaum tab tom noj amiodarone, diltiazema, gemfibrozil, cyclosporine, niacin, fusidic acid, danazole, verapamil, fibrate.

Nyob hauv kev cuam tshuam ntawm Zokor ua kom nrov loj coumarin anticoagulants.

Thaum noj ntau dua 1 liv ntawm cov kua txiv kab ntxwv qaub ib hnub, ib qho kev nce siab hauv kev kho mob ntshav feem ntau ntawm simvastatin tau sau tseg, uas ua rau muaj feem ntau ntawm rhabdomyolysis.

Thaum noj 20-40 mg ntawm simvastatin ib hnub, cov nyhuv yog potentiated coumarin anticoagulantsCov. Raws li qhov tshwm sim, txoj kev pheej hmoo ntawm los ntshav ntau ntxiv.

Zokor Forte - cov tshuaj rau kev kho mob ntawm cov hlab plawv thiab mob atherosclerosis

Zokor Forte yog ib qho zoo tshaj plaws tshuaj siv los kho kev mob plawv thiab qee yam kev kho plawv.

Cov tshuaj no tau nthuav tawm hauv cov qauv ntsiav tshuaj yooj yim, thiab nws lub hauv paus yog hypolipedimic tshuaj simvastatin.

Kev siv cov tshuaj raws li cov lus qhia txo txoj kev pheej hmoo tuag nyob hauv cov neeg mob plawv.

Feem ntau, noj Zocor Forte ntsiav tshuaj ib hnub ib zaug raws li kws kho mob tau sau tseg.

Ua ntej pib ib chav kawm ntawm txoj kev kho mob, nws yog ib qho tseem ceeb kom paub koj tus kheej nrog txhua tus yam ntxwv ntawm cov tshuaj no, nrog rau kev coj mus rau hauv tus account yuav muaj kev phiv thiab contraindications.

Zokor Forte cuam tshuam nrog lwm cov tshuaj li cas?

Ua ntej pib noj cov ntsiav tshuaj Zokor Forte, koj yuav tsum them sai sai rau cov yam ntxwv ntawm kev cuam tshuam nrog lwm cov tshuaj.

Nrog nws txoj kev tswj hwm ua ke nrog danazol, verapamil, amiodarone lossis cyclosporine, qhov kev pheej hmoo ntawm kev tsim myopathy nce.

Kev siv zokora Forte tib txhij thiab cov tshuaj uas cuam tshuam nrog cov kua tsib kua qaub yog muab cov txiaj ntsig zoo kho.

Nws kuj tseem yuav tsum tau nyob rau hauv lub siab hais tias muaj ntau tus naj npawb ntawm cov tshuaj uas contraindicated yuav noj nyob rau hauv nrog cov ntsiav tshuaj Zokor Forte. Cov no suav nrog:

erythromycin,
itraconazole,
ketoconazole,
telithromycin
nefazodone.

Cov muaj pes tsawg leeg ntawm lipid-txo tus neeg sawv cev

Ntxiv rau cov nquag nquag ntawm simvastatin, Zokor ntsiav tshuaj hauv lawv cov muaj pes tsawg leeg ntxiv tshuaj. Ntawm lawv yog:

lactose thiab hypromellose,
MCC
ascorbic thiab citric acid,
pob kws nplej siab
magnesium stearate,
hlau oxide (daj thiab liab).

Pharmacodynamics thiab pharmacokinetics

Zokor inhibits HMG-CoA reductase nrog nws cov metabolites thiab tiv thaiv cov synthes ntawm mevalonate, uas txo cov khoom tsim tawm ntawm stearols thiab roj molecules. Ua ke nrog cov tshuaj tiv thaiv tsis haum, cov tshuaj ua kom cov receptors hauv daim siab mob hlwb uas teb rau cov lipids phaus tsawg. Cov receptors ntes cov lwg me me ntawm LDL feem thiab txhim kho lawv lub catabolism.

Lub tshuab kev ua ntawm statins

Thaiv ntawm HMG-CoA reductase nrog simvastatin ua rau cov tshuaj muaj txiaj ntsig los ntawm kev noj cov tshuaj no:

qis tag nrho cov roj (index),
txos qhov LDL feem,
txo qis dua cov lwg me me ntawm triglycerides thiab cov roj cholesterol ntawm VLDL,
txos apolipoprotein B,
high-density lipids (HDL) nce rau - 14.0%,
nce hauv apoA qhov ntsuas.

Thawj qhov tshwm sim tshuaj los ntawm kev siv Zokor tuaj yeem hnov tom qab ob lub lis piam, thiab qhov siab tshaj plaws - tom qab 30-45 hnub txij hnub nkag.

Pharmacokinetics Zokor hauv tib neeg lub cev tau raug pom zoo raws li hauv qab no:

qhov siab tshaj plaws ntawm simvastatin hauv cov ntshav yog ib thiab ib nrab rau ob teev tom qab kev tswj hwm qhov ncauj. Kev siv tau nyob ntawm qhov muab tshuaj los ntawm tus kws kho mob.
cov tshuaj nquag muab tso rau hauv lub cev tsis pub ntau tshaj 85% ntawm qhov kev noj ntau npaum qhov ncauj,
bioavailability ntawm cov tshuaj - 20%,
cov tshuaj nkag rau hauv cov teeb meem placental thaum cev xeeb tub,
95% ntawm cov tshuaj khi rau cov protein thiab lawv cov sib txuas,
tsis muaj kev sib txuam ntawm simvastatin hauv lub cev, uas tso cai rau koj siv cov tshuaj rau kev siv mus ntev,
ib nrab-lub neej ntawm simvastatin yog los ntawm 18 txog 20 teev,
Zokor tshem tawm 70% nrog kev pab ntawm bile acids thiab hnyuv nrog quav,
10% ntawm lub ntsiab tiv thaiv yog tawm hauv cov zis.

Kev taw qhia rau siv thiab contraindications

Sau ntawv rau lipid-txo tus neeg sawv cev Zokor rau kev kho mob ntawm qee cov pathologies. Ntawm lawv yog:

thawj heterozygous tsev neeg hypercholesterolemia,
homozygous caj mob hyperlipidemia,
sib xyaw hypercholesterolemia,
dysbetalipoproteinemia Ntxiv rau kev noj haus,
hypertriglyceridemia nyob rau hauv ua ke nrog kev noj haus.
Txhawm rau ua kom qeeb qhov loj zuj zus ntawm cov kab mob atherosclerosis.

Tsis tas li ntawd, cov tshuaj yog kho raws li kev tiv thaiv kab mob thib ob hauv lub sijhawm tom qab lub sijhawm thiab tom qab mob hlab ntsha tawg.

Kev siv cov statin rau cov hom phiaj prophylactic kuj ua tau zoo, uas yog rau:

kev tiv thaiv ntawm myocardial infarction thiab cerebral mob stroke,
txo cov xwm txheej ntawm kev mob hlwb tsis txaus thiab lub neej hauv lub xub ntiag ntawm cov kab mob no,
thaiv cov zaus thiab kev siv ntawm ischemic transient tawm tsam,
raug ncua ntawm kev vam meej ntawm cov kab mob atherosclerosis,
txo qis ntawm cov roj cholesterol LDL, thiab nce HDL feem hauv cov ntshav ntshav.

Cov txheej txheem sib khi rau statins

Statins tsis yog kws kho rau cov xwm txheej thiab kev cuam tshuam ntawm tus neeg mob lub cev:

intolerance mus rau Cheebtsam thiab lactose,
kev nce transaminases hauv siab hlwb,
mob siab rau tus mob ntu nyob rau theem kev loj hlob ntawm pathology,
ntau hom kab mob siab thiab kab mob ntsws,
leeg myopathy
keeb kwm ntawm cov leeg mob hauv tus neeg mob
thaum cev xeeb tub thiab lactation,
cov me nyuam qis dua 10 xyoo.

Cov poj niam hauv lub hnub nyoog deev me nyuam tau sau tseg rau cov ntsiav tshuaj tiv thaiv kab mob tiv thaiv zoo nkaus xwb. Yog tias tus poj niam pom tau tias lub cev xeeb tub hauv kev kho mob, cov tshuaj tam sim ntawd raug muab tshem tawm, vim tias simvastatin dhau ntawm qhov kev tiv thaiv qhov chaw thiab tuaj yeem cuam tshuam qhov tsim ntawm lub pob txha thiab cov leeg nqaij hauv lub menyuam, nrog rau kev txhim kho intrauterine ntawm lub siab cell pathologies.

Cov menyuam yaus hnub nyoog qis dua 10 xyoo tsis tau muab tshuaj rau cov tshuaj vim tias qhov muaj kev pheej hmoo loj ntawm kev mob myopathy thiab rhabdomyolysis ntawm cov leeg hlwb.

Kev qhia rau kev siv

Zokor tau noj ib hnub ib zaug. Qhov no yog qhov ua tau zoo tshaj plaws ua ntej yuav mus pw. Cov ntsiav tshuaj tsis tuaj yeem zom, tab sis yuav tsum nqos tag nrho, thiab ntxuav kom huv nrog qhov muaj dej txaus.

Ua ntej pib txoj kev kho mob statin, tus neeg mob yuav tsum yauv tsum noj cov roj cholesterol mus li 1-2 lub hlis. Kev noj zaub mov noj yuav tsum ua raws li tag nrho kev kho mob ntawm Zokor.

Tus kws kho mob xaiv cov ntau npaum nruj rau txhua tus neeg mob, raws li cov yam ntxwv ntawm lub cev, qhov xwm txheej ntawm cov kab mob thiab qhov kev loj hlob ntawm nws, thiab nws tuaj yeem yog los ntawm 5 mg txog 80 mg rau ib hnub. Koj tuaj yeem nce ntxiv ntawm qhov tshuaj txhua hnub kom tsis pub ntxov dua tom qab 4-lub lim tiam ntawm kev noj cov ntsiav tshuaj. Ntau tshaj 80.0 mg ntawm qhov muaj feem raws simvastatin ib hnub twg tsis tau hais rau cov neeg mob.

Pib cov tshuaj kawm nrog 5 mg, 10 lossis 20 mg. Thawj lub sijhawm teem nyob ntawm lub pathology thiab ntsuas ntawm lipid profile:

Kev kho mob ntawm hypercholesterolemia yuav tsum tau pib nrog ntau npaum ntawm 10 mg. Thaum lub sij hawm kho, koj tuaj yeem nce qhov ntau npaum li cas (maj mam), kom ntau tshaj qhov tau tso cai ib hnub - 80 milligrams.
Txog kev tiv thaiv cov mob plawv coronary nrog hyperlipidemia los yog dyslipidemia, ib koob tshuaj 40 mg tuaj yeem raug kho.
Txog kev kho mob homozygous caj hlav ntshav hypercholesterolemia, tus kws kho mob tau sau ntawv rau ib koob ntawm 40 mg. Yog tias tsis muaj tshuaj tshwm sim, tom qab ib hlis ntawm kev kho mob, ib koob tshuaj 80 mg yog tsim muaj. Qhov koob tshuaj tau muab faib rau tag kis sawv ntxov ntawm 40 mg thiab yav tsaus ntuj koob tshuaj nyob rau tib lub tshuaj.
Cov neeg laus laus tsis tas yuav kho qhov tshuaj ntawm cov tshuaj. Kuj tseem tsis tas yuav tsum muaj qhov hloov kho rau cov qog hloov tshiab ntawm lub hlwb.
Cov menyuam yaus txij thaum 10 xyoo nrog lub caj mob hypercholesterolemia ntawm homozygous yam, tus kws kho mob tau sau ntawv rau 10 koob tshuaj rau ib hnub. Rau cov menyuam hnub nyoog qis dua 18 xyoo, koob tshuaj rau txheej txheem kho yuav raug nce ntxiv rau 40 milligrams ib hnub. Qhov ntau npaum ntawm 80 mg rau thaum yau yog tsis kho.

Muaj cov tshuaj tsis haum thiab noj tshaj

Firstins-the statins raug pom zoo los ntawm lub cev, feem ntau cov kev mob tshwm sim tuaj yeem tshwm sim thaum kho nrog tshuaj nrog kev siv 40 mg, los yog thaum noj tshuaj nrog qhov siab tshaj plaws hauv ib hnub - t 80 mg.

Tsis pub ntau dua 10% ntawm cov neeg mob ntsib cov kev tawm tsam lub cev rau kev noj tshuaj:

kev txhim kho ntawm lub raum,
plaub hau poob
daim tawv nqaij dermatomyositis,
kiv tob hau, mob taub hau,
dyspepsia
daj thiab zaub mov etiology,
myalgia thiab myopathy,
cramps
mob txhaj thuv tas
nqaj tawv,
neuropathy ntawm chav peripheral,
rhabdomyolysis,
urticaria thiab khaus.

Tsis tshua muaj cov tsos mob yog:

txog siav
o ntawm qhov khoom nruab nrog cev,
arthralgia
nkees
thrombocytopenia
nce hauv ESR,
impotence rau tus txiv neej.

Cov tsos mob tsuas yog ua rau muaj kev cuam tshuam ntawm lub cev,

kev nce hauv phosphokinase enzyme,
nce hauv creatine phosphokinase index,
qhov muaj zog nce hauv transaminase Performance index hauv daim siab ua haujlwm.

Thaum noj ntau dhau, siv tshuaj kho tus mob thiab lub plab zom mov tau siv. Tus txheej txheem hemodialysis ua tsis tau zoo.

Txhua tus neeg mob yuav tsum paub txog qhov ua tau ntawm kev txhim kho cov leeg mob ua ntej noj. Koj yuav tsum them sai sai rau cov nta zoo li no:

nrog rau txhua qhov sib zog ntawm qhov mob hauv cov leeg nqaij lossis pob txha, tus neeg mob yuav tsum ntsib kws kho mob. Feem ntau, kev noj Zokor ua rau cov leeg tsis muaj zog,
thaum kho nrog cov ntsiav tshuaj noj ntawm 20 mg lossis 40 mg ntawm cov tshuaj tivthaiv uas nquag, kev tshuaj xyuas tas li ntawm kev ua si ntawm creatine phosphokinase hauv cov ntshav, nrog rau kev ua haujlwm ntawm lub raum, tsim nyog.

Kev nce hauv creatine phosphokinase index yog cov cim ntawm kev tsim cov myopathy hauv cov leeg mob. Txoj kev kho yuav tsum nres los yog cov koob txhaj tshuaj kom haum rau yam tsawg kawg nkaus.

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob

Kev txheeb xyuas txog Zokora feem ntau zoo. Tag nrho cov neeg mob thiab kws kho mob nco tau cov txiaj ntsig zoo ntawm cov tshuaj:

Tus neeg sawv cev hypolipidemic Zokor ua tau zoo rau txhua ntu ntawm lipid metabolism hauv lub cev. Tsis tas li ntawd, nws yog siv los ua prophylaxis rau cov kab mob loj ntawm cov kab mob hematopoietic thiab lub plawv, zoo li nyob rau theem ntawm kev rov qab los ntawm yav dhau los mob plawv thiab mob plawv nres, zoo li nyob rau theem ntawm kev rov qab mob tom qab.

Cov lus qhia tshwj xeeb

Zoo li lwm yam tshuaj - inhibitors ntawm GM-CoA reductase, Zokor tuaj yeem ua rau kev txhim kho myopathiesCov. Qee lub sij hawm nws ua nws tus kheej hauv daim ntawv rhabdomyolysis, uas qee kis yog nrog mob raum tsis zoo.

Zam kev sib koom tes ntawm Zokor thiab kev siv yeeb tshuaj, uas, thaum noj tib lub sijhawm, tuaj yeem ua rau mob tshwm sim ntawm myopathy.

Txhua tus neeg mob uas tau xaj Zocor yuav tsum raug ceeb toom ntawm qhov ntxim nyiam ntawm kev nthuav qhia. myopathiesthiab qhov xav tau, tom qab kev txhim kho thawj cov tsos mob ntawm tus kab mob no, tam sim ntawd sab laj nrog kws kho mob. Thawj lub sijhawm twg los ntawm txoj kev txhim kho myopathy, txoj kev kho yuav tsum raug ncua.

Hauv qee tus neeg mob uas tau txais Zokor, ib qho kev nce qib ntawm daim siab enzymes tau sau tseg. Tom qab ncua kev kho mob, qhov ntsuas yuav maj mam rov qab mus rau theem pib.

Ua ntej pib txoj kev kho mob, nws yog ib qho tseem ceeb kom ua qhov kev kawm ntawm daim siab kev ua haujlwm. Txoj kev tshawb no yuav tsum rov qab ua dua nce cov koob tshuaj simvastatin mus rau qhov siab tshaj plaws txhua hnub.

Nrog mob raum tsis ua haujlwm, tus neeg mob tsis tas yuav txo qhov tsawg ntawm cov tshuaj. Hauv kev mob raum tsis ua haujlwm, ib koob tshuaj ntau dua 10 mg tuaj yeem raug kho tsuas yog tom qab kev pom zoo ntawm tus kws kho mob tuaj koom.

Cov lus thiab cov xwm txheej ntawm kev cia

Lub txee lub neej ntawm cov tshuaj no los ntawm lub sijhawm nws tsim tawm yog ob xyoos.

Cov ntsiav tshuaj yuav tsum muab cia rau hauv qhov chaw ntim thawj ntawm qhov kub tsis tshaj + 25-30⁰, nyob hauv qhov chaw tsaus thiab qhuav uas cov menyuam yaus siv tsis tau.

Tshuaj Zokor Forte yog tshuaj nkaus xwb.

Nws tus nqi nruab nrab hauv cov khw muag tshuaj Lavxias nyiaj mus rau 450-500 rubles (rau pob uas muaj 14 ntsiav tshuaj) thiab 700-750 rubles (rau 28 ntsiav tshuaj)

Cov tsev muag tshuaj hauv Ukraine muab coj mus yuav cov tshuaj no ntawm tus nqi li ntawm 150 txog 500 hryvnia, nyob ntawm seb muaj pes tsawg lub tshuaj hauv pob.

Cov tshuaj lag luam niaj hnub muaj ntau cov qauv zoo heev ntawm Zokora Forte, uas muaj cov tshuaj zoo ib yam thiab muaj cov nyhuv hypolipedic.

Thaum xaiv cov tshuaj hloov pauv tshwj xeeb, nws raug nquahu kom sab laj nrog kws kho mob.

Cov nyiam tshaj plaws ntawm Zocor Forte ntsiav tshuaj yog:

Cov tshuaj Zokor Forte tsim nyog xyuas cov lus qhia zoo rau nws qhov chaw nyob vim nws yooj yim ntawm kev siv thiab siab kho cov nyhuv.

Feem ntau ntawm cov neeg mob uas tau siv nws rau kev tawm tswv yim thiab kho cov hom phiaj, tau sau tseg tias qhov kev txo qis hauv cov cholesterol, ntxiv rau cov txiaj ntsig zoo rau lub xeev ntawm cov hlab plawv.

Ntawm qhov kawg ntawm tsab xov xwm no, koj tuaj yeem pom cov ncauj lus kom ntxaws ntxaws thaum siv cov tshuaj no. Thiab yog tias koj muaj koj tus kheej kev paub hauv kev siv Zokor Forte ntsiav tshuaj, nco ntsoov qhia koj cov kev xav nrog lwm tus neeg tuaj saib lub xaib.

Dab tsi yuav tsum xav txog ua ntej noj Zocor Forte ntsiav tshuaj?

Cov tshuaj Zokor Forte, nthuav tawm hauv cov qauv hauv cov ntsiav tshuaj, yog rau kev kho mob thiab tiv thaiv kab mob plawv, nrog rau atherosclerosis.
Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 80 mg.
Nws yog txwv tsis pub noj tshuaj thaum cev xeeb tub thiab lactation, mob siab mob siab, ntxiv rau thaum muaj qee tus neeg tsis kam txais ua ke rau cov khoom siv.
Hauv lub sijhawm ua haujlwm ntawm kev kho mob, haus dej cawv yuav tsum tau cais tawm ntawm cov khoom noj kom zoo.
Lub chav kawm ntawm txoj kev kho mob los ntawm tus kws kho mob yuav tsum tsis pub dhau.

Cov lus qhia thiab siv Zokor: analogues, tshuaj xyuas, muaj pes tsawg leeg, tus nqi

Lekarstva.Guru> Z> Cov lus qhia thiab cov ntawv thov Zokor: analogues, tshuaj xyuas, muaj pes tsawg leeg, nqi

Zokor forte yog cov tshuaj uas tiv thaiv kev txhim kho ntawm cov kab mob ntawm cov hlab plawv. Nws tsis tsuas yog txo qis qib cov roj (cholesterol) phem nyob hauv tus neeg mob cov ntshav, tab sis kuj tseem theem cov qib roj (cholesterol) phem rau qhov zoo. Ua tsaug rau nws lub zog tej yam yees siv, Zokor txo tag nrho kev tuag ntawm cov neeg mob los ntawm 30%! Thiab nyob rau hauv cov neeg mob ntshav qab zib, qhov kev pheej hmoo ntawm cov mob caj dab yog txo los ntawm ntau npaum li 55%!

Zokor - yog dab tsi?
Daim ntawv tso tawm
Kev ntsuas rau siv
Cov Yuav Tsum Muaj
Cov lus qhia rau kev siv, ntau npaum li cas
Sab sij huam

Zokor - yog dab tsi?

Zokor yog ib qho tshuaj lipid-txo cov tshuaj lom neeg. Nws tau txais los ntawm fermentation los ntawm Aspergillus terreus. Lub active tshuaj ntawm yeeb tshuaj Zokor forte - simvastatin.

Qhov no yog qhov ua tsis muaj zog lactone, tau txais mus rau hauv cov txheej txheem ntawm hydrolysis, nws cov ntaub ntawv sib xyaw ua ke hydroxy-acid derivative. Nws, nyeg, yog cov metabolite uas inhibits HMG-CoA.

HMG-CoA yog ib qho kev rov ua lub cev, lossis ib qho enzyme uas muaj peev xwm los ua kom cov thawj thiab txo qis ntawm cov theem ntawm cov roj ntsha biosynthesis hauv tib neeg lub cev.

HMG-CoA, tig mus rau mevalonate, yog thawj theem ntawm cov roj ntsha biosynthesis. Yog li, kev siv Zokor forte tsis ua rau kev txuam cov txheej txheem ntawm cov tshuaj lom sterols hauv lub cev.

Qhov no tau lees paub los ntawm kev tshawb nrhiav hauv Tebchaws Askiv rau 5 xyoos thiab 5 lub hlis.

Ntxiv rau txhua qhov ntawm cov saum toj no, HMG-CoA tuaj yeem hloov pauv mus rau Co-A, ib qho enzyme uas koom nrog ntau ntawm cov txheej txheem biosynthesis.

Nws yuav tsum raug sau tseg tias ntau cov kev tshawb fawb tseem paub meej tias - cov tshuaj Zokor sib luag zoo rau txhua tus neeg mobCov. Kev ua hauj lwm zoo tsis yog nyob ntawm lub hnub nyoog, poj niam txiv neej, qib roj cholesterol lossis qhaj / muaj kev kho kom zoo.

Yog tias koj tsis ntseeg qhov kev kho koj muaj, kev tshuaj xyuas online tuaj yeem pab koj ntsuas txhua qhov zoo thiab qhov tsis zoo ntawm cov kev kho mob ntawd.

Cov lus qhia rau kev siv, ntau npaum li cas

Raws li cov lus qhia, ua ntej pib siv cov tshuaj Zokor forte, tus neeg mob yuav tsum tau kho tus mob hypocholesterol noj cov zaub movCov. Nws yog ib qho tsim nyog yuav tsum ua raws li kev noj haus zoo li no thoob plaws hauv kev kho mob.

Cov koob tshuaj uas tau pom zoo hauv cov lus qhia yog los ntawm 5 mg txog 8 mg. Nws yog ib qho tsim nyog yuav tsum tau siv cov tshuaj thaum yav tsaus ntuj, ib zaug ib hnub. Nyob rau lub sijhawm xaiv cov tshuaj zoo tshaj plaws ntawm cov tshuaj, lub caij nyoog yuav tsum raug pom: koj yuav tsum hloov pauv txhua hnub ntawm Zocor tsis pub ntau tshaj 1 zaug hauv 4 lub lis piam. Qhov siab tshaj plaws tau tso cai ntawm Zokor forte hauv ib hnub yog 80 mg.

Kev saib xyuas tshwj xeeb txog kev kho qhov ntsuas yuav tsum tau muab rau cov neeg mob IHD lossis qhov pheej hmoo ntawm kev txhim kho IHD. Qhov siab tshaj plaws pub siv tau rau ib hnub, rau cov neeg mob zoo li no, nws yog qis dua - 40 mg. Siv yeeb tshuaj 1 zaug hauv ib hnub, thaum yav tsaus ntuj.

Ua raws li cov lus qhia cov tshuaj yuav tsum tau sib koom ua ke nrog rau cov khoom noj tshwj xeeb thiab kev tawm dag zog rau cov neeg mob:

Nrog ischemic mob plawv lossis muaj kev pheej hmoo ntawm kev tsim ischemic mob plawv,
Mob ntshav qab zib mellitus
Keeb kwm ntawm kab mob cerebrovascular,
muaj peripheral vascular kab mob.

Cov neeg mob uas muaj hypercholesterolemia uas tsis suav nrog cov npe saum toj saud tau sau cia noj ntau yam sib txawv. Lub koob tshuaj qis hauv qhov no yog 20 mg. Noj tshuaj ib hnub ib zaug, yav tsaus ntuj.

Rau cov neeg uas kev kho mob cuam tshuam txog kev txo qis hauv LDL ntau ntau, qhov kev pib txhaj tshuaj tau nce mus rau 40 mg. Yog hais tias tus neeg mob tau mob me dua hypercholesterolemia, ces lub hauv paus tus nqi ntawm cov tshuaj yog 10 mg.

Kev xaiv ntawm cov koob tshuaj yuav tsum tau ua raws li cov lus qhia, nrog lub sij hawm qhia ntawm qhov hloov pauv koob tshuaj.

Homositic tsev neeg hypercholesterolemia muab rau ob hom kev txais tosCov. Ua ntej: cov tshuaj tau noj 1 zaug hauv ib hnub, thaum yav tsaus ntuj, hauv qhov ntau npaum li 40 mg. Thib ob: 80 mg ntawm cov tshuaj tau muab faib ua peb koob:

Cov ntaub ntawv siv no yog siv yog tias lwm txoj kev kho mob, nrog kev txo loj hauv cov cholesterol, yuav tsis siv rau hauv qhov no. Los yog Zokor tau siv los ua kev kho mob txuas.

Yog hais tias tus neeg mob noj cov fibrates, cov koob tshuaj uas tsim nyog tau muab kho txhua tus los ntawm tus neeg mob, nyob ntawm seb cov tshuaj twg fibrates tau raug kho.

Txij li thaum lub raum tsis ua haujlwm yog qhov hnyav contraindication rau kev kho mob nrog Zokor forte, lawv feem ntau sim hloov nws nrog analogues.

Tab sis yog tias qhov kev xaiv no tsis tuaj yeem lees txais, nws yog qhov tseem ceeb muab tag nrho cov teeb meem tshwm sim thiab txiav txim siab tias tus neeg mob, nws raug nquahu kom siv Zokor forte.

Txawm li cas los xij, Yog hais tias tus neeg mob tau mob me me lub raum tsis ua haujlwm, tus qauv koob tshuaj tsis raug. Txij li thaum albeit hauv qee qhov me me, tab sis cov tshuaj tau kho tas li los ntawm lub raum.

Sab sij huam

Raws li kev tshawb nrhiav, kev pheej hmoo ntawm kev phiv tom qab thov Zokor forte tsuas yog 2%. Vim li no, kev kho mob nrog Zokor ntsiav tshuaj yog qhov zoo dua rau analogues. Ib qho ntxiv, txoj cai tswj hwm nqe ntawm cov khoom yog tsis overpriced. Tus nqi nruab nrab ntawm cov tshuaj hauv Ukraine yog li ntawm 15 txog 30 UAH. Tus nqi nruab nrab hauv Russia yog los ntawm 400 txog 700 rubles.

Ua ntej txoj kev nquag siv cov tshuaj hauv kev kho mob, 1% yog mob phiv li ntawdnyiam:

Lwm yam cuam tshuamuas cuam tshuam nrog kev siv tshuaj yeeb nyob rau hauv 0.5-0.9% ntawm cov neeg mob:

Muaj pov thawj ntawm qee yam tsis tshua muaj mob myopathy.

Cov tsos mob ntawm cov tsos mob zoo li no kuj ua tau:

Kiv taub hau
Xeev siab
Kab mob siab
Zawv plab
Kev mob caj dab
Ntuav
Qhov muag daj
Mob paj hlwb peripheral,
Rhabdomyolysis,
Neej Hmoob
Dermatomyositis
Khaus
Cov tawv nqaij ua pob
Mob leeg
General tsis muaj zog
Mob Kev Plab

Kev tshawb fawb hauv chav kuaj thiab dhau los ntawm kev xyaum ntau xyoo tsis qhia meej tias yuav muaj kev cuam tshuam dab tsi ntawm kev haus ntau dhau ntawm cov neeg mob. Kev siv tshuaj ntau tshaj plaws yog 3.6 g.

Ua ntej pib kev kho mob, nws yog ib qhov tsim nyog ib txhij txhua kawm txog lub raum kev limCov. Xws li kev tshawb nrhiav yuav tsum tau rov qab ua ntej txhua qhov nce hauv cov koob tshuaj.

Hauv cov neeg mob noj cov tshuaj, qhov hloov ntawm theem ntawm hepatic enzymes tau sau tseg. Txawm li cas los xij, tom qab qhov tso tseg ntawm qhov kawg, cov ntsuas pib maj mam rov qab zoo li qub.

Yog tias tus neeg mob tau mob lub raum tsis zoo, kev nce ntxiv ntawm qhov pib (10 mg) tsuas yog ua tau tom qab kev sab laj thiab kev tso cai ntawm tus kws tshaj lij.

Kev piav qhia ntawm cov tshuaj Zocor

Kuv tau ntshai pom zoo rau kev kho, tab sis tus kws kho mob hais tias, hauv kuv qhov xwm txheej, lwm txoj kev kho yuav tsis muaj txiaj ntsig. Zoo hmoo, lawv ntxias kuv tias kuv twb nyob ntawm qhov ua kom rov zoo.

Milena, Kharkov

Kuv lub raum khiav tsis zoo thiab cov roj (cholesterol) siab. Kuv lag luam pom zoo yuav kho Zokor. Rau ntev lub sij hawm tsim nyog tau xaiv tau xaiv, tab sis cov no yog trifles, qhov loj tshaj plaws yog tias tus kabmob muaj qab. Zoo siab kuv pom zoo.

Alexander, Minsk

Hais qhov tseeb, Kuv tsis yog qhov tshwj xeeb ntawm kev siv tshuaj, yog li tus kws kho mob tau hais - txhais tau tias peb yuav tsum pom zoo. Qhov loj tshaj plaws yog kom pom tus kws paub tshwj xeeb uas koj ntseeg, ces txhua yam kev kho mob yuav ua tiav. Feem ntau, kuv qhov kev paub yog qhov zoo.

Svetlana Oryol

Zokor: cov lus qhia rau kev siv, nqe, xyuas thiab analogues

Kev siv tshuaj hypolipidemic Zokor yog siv los txo qhov ntshav cov roj nyob hauv qhov ntsuas ntshav hauv hypercholesterolemia. Zokor yog ib qho inhibitor ntawm HMG-CoA reductase thiab yog ib feem ntawm pawg pharmacological ntawm statins. Hauv tsab xov xwm no peb yuav xav txog cov lus qhia rau kev siv tshuaj yaj yeeb Zokor, kev qhia thiab sib kis, cov qauv thiab tshuaj xyuas.

Cov ntaub ntawv pharmacological

Lub chaw tsim tshuaj paus tsim cov tshuaj hauv cov qauv ntsiav tshuaj. Cov ntsiav tshuaj nrog qhov ntau npaum li 10 mg ntawm cov nquag sib xyaw ua ke muaj lub teeb xim liab dawb, lub ntsej muag kheej li lub cev ntawm ib sab, thiab kos duab yog nyob ntawm qhov tod.

Zokor ntsiav tshuaj nrog qhov ntau npaum ntawm 20 mg simvastatin muaj xim daj-xim av, lub ntsej muag kheej li lub cev ntawm ib sab, thiab kos duab yog nyob rau lwm qhov.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm simvastatin 40 mg (Zokor Forte) muaj cov xim xim daj, lub qe kheej rau ntawm ib sab, thiab kos duab yog nyob rau lwm.

Ntim hauv cov ntsiav tshuaj hauv cov hlwv ntawm 14 daim. Txhua daim npav cardboard tuaj yeem ntim 1 lossis 2 lub hlwv.

Qhov no muaj tseeb los ntawm cov lus qhia rau siv. Cov lus qhia ntawm Zokor yuav raug txiav txim siab hauv qab no.

Kev ntsuas rau siv

Cov tshuaj tau pom zoo rau kev siv los ntawm cov neeg mob uas koom nrog cov pab pawg pheej hmoo rau kev txhim kho mob ischemia. Tseem muaj kev pheej hmoo suav nrog tus neeg nrog cov pathologies xws li:

Kab mob ntawm peripheral ncig.
Mob ntshav qab zib mellitus.
Cerebrovascular pathology.

Cov tshuaj yeeb yaj kiab tuaj yeem siv los kho cov neeg mob kev txom nyem los ntawm ischemic mob plawv, hypercholesterolemia. Hauv qhov no, nws yuav pab tiv thaiv atherosclerotic pathologies ntawm lub plawv thiab cov hlab ntshav.

Cov npe ntawm qhov ntsuas pom rau kev siv tshuaj "Zokor" yog qhov zoo heev.

Nws tseem tuaj yeem pom zoo rau kev siv rau hauv cov xwm txheej hauv qab no:

Homozygous tsev neeg daim ntawv ntawm hypercholesterolemia (ua ke nrog kev kho kev noj haus, lwm txoj hauv kev).
Cov roj (cholesterol) tsawg ntawm cov lipoproteins uas ntau dua nrog cov thawj hypercholesterolemia tshwm sim los ntawm kev noj zaub mov noj.
Hypertriglyceridemia.
Txhawb siab theem ntawm apolipoprotein B, tag nrho cov roj (ua ke nrog kev kho kev noj haus).

Kev cuam tshuam tsis zoo

Raws li cov lus qhia rau kev siv thiab tshuaj xyuas "Zokor", cov tsos mob tsis zoo no yuav tshwm sim hauv tus neeg mob thaum kho:

Arthralgia, ntxiv ESR, mob caj dab, mob eosinophilia, thrombocytopenia, dermatomyositis, vasculitis, angioedema.
Ua rau lub siab ua haujlwm tsawg, rhabdomyolysis, mob myopathy.
Khaus, alopecia, tawm pob.
Ua txhaum ntawm kev pw tsaug zog, nco qab, paresthesia, peripheral neuropathy, mob nriaj, kiv taub hau.
Plawv tsis haum, dav dav tsis muaj zog, mob taub hau.
Kev tso quav tiv thaiv, tsam plab, mob plab, mob plab.

Feem ntau, cov tshuaj tau zoo txaus los ntawm cov neeg mob.

Kev siv tshuaj

Siv cov tshuaj "Zokor" qhov ncauj, tsis tas yuav hais txog zaub mov noj. Qhov nruab nrab txhua hnub koob ntawm cov tshuaj yog 5-80 mg. 80 mg - qhov siab tshaj plaws uas tau tso cai ntawm simvastatin, uas tuaj yeem noj thaum nruab hnub.

Cov koob tshuaj yog xaiv los ntawm cov kws tshaj lij ib tus zuj zus. Yog li, rau lub hom phiaj ntawm kev kho thiab tiv thaiv cov kab mob hauv plawv nrog rau kev sib xyaw nrog kev noj zaub mov, nws yog qhia kom noj 40 mg ntawm Zokora ib hnub.

Txhawm rau kho hypercholesterolemia, nws yog qhia kom noj 20 mg ntawm Zokor ib hnub.

Ua rau daim siab

Cov kev tshawb fawb soj ntsuam hauv cov neeg mob cov neeg laus tau txais simvastatin tau pom tias muaj kev nce siab hauv cov qib siab hauv lub siab. Nrog rau kev ua kom tiav los yog cuam tshuam kev siv tshuaj, cov kev ua ntawm transaminases feem ntau maj mam rov qab mus rau lawv tus nqi qub. Qhov no tsis cuam tshuam txog kev daj ntseg lossis lwm yam kev mob tshwm sim, tab sis yuav qhia qhov txawv txav ntawm cov txiaj ntsig kev soj ntsuam daim siab thiab / lossis dej cawv ua ntej pib kho. Hypersensitivity tsis tau raug kuaj pom.

Ib pob ntawm 28 Zokora ntsiav tshuaj nrog tshuaj 20 mg yuav raug nqi kwv yees li 750 rubles, nrog tshuaj ntau 40 mg - 500 rubles. Nws nyob ntawm thaj av thiab cov tsev muag tshuaj lub network.

Analogs ntawm Zokora

Yog tias tsim nyog, Zokor tuaj yeem hloov nrog ib qho ntawm cov kev npaj hauv qab no: Simvor, Zovatin, Simgal, Vabadin, Levomir, Aterostat, Simlo, Simvakard, Avestatin, Simvastatin, Akorta, Pravastatin, Simvastol, Ariescor, Simgal, Lovastatin, Lipitor, Liptonorm, Rosulip, Rosart, Tevastor, Atomax , Liprimar, Atoris, Rosucard, Vasilip, Roxer, Rosuvastatin, Tulip, Krestor.

Cov txiaj ntsig ntawm cov tshuaj no zoo ib yam, yuav tsum siv hom tshuaj tshwj xeeb rau ib kis twg yuav tsum tau txiav txim los ntawm kws kho mob.

"Krestor" yog ib qho ntawm cov qauv ntawm "Zokor". Cov khoom xyaw nquag hauv nws cov muaj pes tsawg leeg yog calcium rosuvastatin. Cov tshuaj ntxiv yog: magnesium stearate, glycerol triacetate, E172, E171, hypromellose, calcium phosphate, lactose monohydrate, crospovidone, microcrystalline cellulose.

Cov chaw tsim khoom "Crestor" yog muaj nyob hauv cov qauv ntsiav tshuaj. Txhua lub ntsiav tshuaj tuaj yeem ntim 5, 10, 20, 40 mg ntawm cov tshuaj muaj zog. Zoo li Zokor, Krestor yog qhov tshuaj kho lipid-txo qis.

Qhov twg yog qhov zoo dua - "Zokor" lossis "Crestor" yog qhov nyuaj rau daws.

Cov cim tseem ceeb rau nws siv yog:

Kev tiv thaiv ntawm kev txhim kho cov hlab ntsha pathologies.
Atherosclerosis
Sib xyaw hypercholesterolemia (raws li ib lub ntsiab lus ntawm cov kev kho mob nyuaj nrog rau kev poob phaus, kev siv dag zog, kev kho kev noj haus).
Kev tiv thaiv, kho mob rau tsev neeg hypercholesterolemia.

"Crestor" yog contraindicated nyob rau hauv lub xub ntiag ntawm xws li muaj sia, pathological tej yam kev mob raws li:

Kev raug tshem tawm rau ib qho twg ntawm cov tshuaj.
Lub hnub nyoog txog 18 xyoo.
Myopathy
Kev kho nrog tshuaj cyclosporin.
Cev xeeb tub, sijhawm lactation.
Cov foos hnyav ntawm hom mob hepatic pathologies, tshwj xeeb, cuam tshuam nrog kev nce ntxiv ntawm tus naj npawb ntawm transaminases hauv cov ntshav.

Tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj, cov tsos mob tsis zoo xws li:

Tubular proteinuria.
Ua neeg ntuj.
Mob plab zom mov, cem quav, pancreatitis, xeev siab.
Ua xua cov lus teb.
Myopathy
Polyneuropathy, mob taub hau.

Noj "Crestor" yuav tsum muaj qhov ncauj, tag nrho, zam kev txhawm rau. Nws raug nquahu kom pib kev siv tshuaj nrog kev pib noj tshuaj ntawm 5 mg, tom qab peb lub lis piam tus kws kho mob txiav txim siab qhov yuav tsum tau ntxiv qhov ntau ntxiv rau 20 lossis 40 mg raws li tus neeg mob txoj kev noj qab haus huv.

Cov neeg mob feem ntau xav tias yam tshuaj twg, Zokor lossis Krestor, zoo dua. Lo lus teb rau lo lus nug no tsis tuaj yeem ua tsis tau. Ua ntej, cov khoom ua kom nquag plias raws li ntau yam khoom xyaw. Thib ob, lub cev ntawm txhua tus neeg yog tus kheej: cov tshuaj zoo rau ib tus neeg mob yuav tsis haum rau lwm tus neeg mob. Yog li ntawd thiaj li tus kws kho mob tshwj xeeb yuav tsum xaiv cov tshuaj kom haum tshaj plaws.

Simvastatin

"Simvastatin" yog ib qho lus piav qhia ntawm "Zokor" hauv nqe lus ntawm cov nquag nquag, nws yog raws li simvastatin. Raws li cov tshuaj pab siv: butylhydroxyanisole, macrogol, talc, hypromellose, ascorbic acid, pob kws hmoov txhuv, lactose, povidone, citric acid, titanium dioxide, calcium stearate.

Cov chaw tsim tshuaj lag luam "Simvastatin" muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, ntim rau hauv hlwv lossis cov kaus poom ntawm cov hnab yas polymer thiab muaj ntau npaum li cas ntawm cov tshuaj nquag 10, 20, 40, 80 mg.

Ntawm cov ntsuas rau kev siv Simvastatin yog cov xwm txheej hauv qab no:

Kev tiv thaiv ntawm kev kho mob ntawm atherosclerosis.
Kev tiv thaiv kev sib hloov ischemic nres, mob stroke.
Kev tiv thaiv ntawm myocardial infarction.
Ua ke ua hom hypercholesterolemia, hypertriglyceridemia (yog tias kev ua kom lub cev txaus thiab kev noj zaub mov tsis muaj txiaj ntsig).
Thawj hypercholesterolemia (yog tias tsis muaj kev ua tau zoo los ntawm cov tshuaj tsis siv tshuaj thiab kev noj haus zoo) rau cov neeg mob uas muaj kev pheej hmoo ntawm kev mob atherosclerosis.

"Simvastatin" yog qhov tseeb contraindicated yuav siv yog tias tus neeg mob muaj cov kab mob zoo li no, muaj sia:

Lub hnub nyoog txog 18 xyoo.
Mob mob siab.
Ib qho kev raug rau ib qho zuj zus hauv cov tshuaj.
Nce AST, ALT.
Myopathy, lwm txoj kev leeg mob plab pob txha.

Ntawm cov txheeb ze contraindications (tej yam mob uas yuav tsum tau ceev faj siv yeeb tshuaj):

Kev phais mob, kev raug mob.
Tshuaj qaug dab peg
Kev ntshaib plab metabolic.
Cov cim ntawm cov kab mob ntawm cov tshuaj endocrine.
Qhov tsis txaus yog dej-electrolyte.
Arterial hypotension.
Kev quav cawv
Lub sijhawm rov ua kom zoo dua tom qab hloov khoom nruab nrog, kho txoj kev kho mob.

Kev siv "Simvastatin" tuaj yeem cuam tshuam rau tus neeg mob lub cev, ua rau cov kev mob tsis zoo xws li:

Mob raum, palpitations, mob hom mob raum tsis ua haujlwm, provoked los ntawm rhabdomyolysis, txo qis potency.
Alopecia, pruritus, dermatomyositis.
Myalgia, rhabdomyolysis, ua haujlwm tsis muaj zog, myopathy, mob leeg.
Ua tsis taus pa luv, mob caj dab, yoo ntawm daim tawv nqaij, nce ESR, kub taub hau, urticaria, photosensitivity, lupus-zoo li mob syndrome, eosinophilia, polymyalgia rheumatica, thrombocytopenia, angioedema.
Mob paj hlwb peripheral.
Kev pw tsis tsaug zog, mob leeg ib ce, hnov qab tsi qab, kiv taub hau, mob duav, mob hlwb, mob taub hau, qhov muag plooj.
Xeev siab ntuav, raws plab mob plab, ntuav, nce AST, ALT, CPK, cem quav, mob epigastric, pom pob txha, txhaws qa.

Kev siv "Simvastatin" yuav tsum pib nrog cov koob tshuaj tsawg kawg nkaus, maj mam ntxiv rau lawv txhua lub hlis. Nws raug nquahu kom siv cov tshuaj ib hnub ib zaug, thaum mus pw, noj 1 lub tshuaj. Qhov ntau npaum li cas yog txiav txim los ntawm tus kws kho mob nyob ntawm tus mob ntawm tus neeg mob. Raws li txoj cai, qhov ua tau ntawm cov tshuaj pom thaum siv 20 mg ntawm cov tshuaj ib hnub.

Tus nqi nruab nrab ntawm ib pob Simvastatin yog 400 rubles.

Simgal tseem yog ib qho analogue ntawm Zokor hais txog cov nquag nquag. Nws muaj simvastatin. Cov khoom siv ntxiv yog: lactose monohydrate, microcellulose, magnesium stearate, citric acid monohydrate, pregelatinized hmoov txhuv nplej siab, butyl hydroxyanisole, ascorbic acid.

Cov chaw tsim tshuaj paus "Simgal" muaj nyob rau hauv daim ntawv foos, ntsiav tshuaj kuj yuav muaj ntau npaum ntawm simvastatin 10, 20, 40 mg.

Cov cim tseem ceeb rau kev siv Simgal:

Kev tiv thaiv ntawm CCC pathologies rau cov neeg mob uas mob ntshav qab zib mellitus, atherosclerosis.
Kev Kho Mob ntawm hypercholesterolemia (thawj, keeb kwm homozygous).
Kev kho los ntawm kev sib xyaw dyslipidemia.

Simgal yog qhov sib txawv hauv cov xwm txheej hauv qab no:

Kev kho nrog tshuaj muaj zog inhibiting cytochrome CYP3A4 (Nefazodon, Telithromycin, Itraconazole, Nelfinar, Clarithromycin, Erythromycin).
Lub sijhawm lactation, cev xeeb tub.
Txhawb cov qib siab hloov pauv.
Exacerbations ntawm hepatic pathologies.
Ua kom muaj kev cuam tshuam yooj yim rau cov tshuaj ntawm cov tshuaj.

Tawm tsam keeb kwm yav dhau los ntawm kev siv "Simgal", cov kev mob tshwm sim tsis zoo no yuav tshwm sim:

Ua kom ntau ntawm alkaline phosphatase, hloov pauv hloov pauv.
Tsis muaj zog, ua pa luv, eosinophilia, photosensitivity, thrombocytopenia, polymyalgia ntawm rheumatic hom, mob caj dab, vasculitis, angioedema.
Asthenia, mob qog nqaij leeg, mob leeg, mob hlwb.
Alopecia, khaus, tawm pob, daj ntseg, mob siab.
Pancreatitis, mob plab, ntuav, tso quav.
Peripheral polyneuropathy, pov thawj, kiv taub hau, duav, txha caj dab, mob taub hau, ntshav liab.
Kev plees kev yi, kev nyuaj siab, kev nco tsis meej, pw tsaug zog.

Nws raug nquahu kom noj Simgal ib zaug ib hnub rau 10-20 mg. Qee qhov xwm txheej, hauv kev pom zoo nrog tus kws tshaj lij, nce ntxiv ntawm qhov koob tshuaj txhua hnub txog 80 mg tau tso cai. Yog tias xav tau, cov ntsiav tshuaj tuaj yeem muab faib ua ntau ntu. Qhov ntau npaum li cas ntawm cov tshuaj yuav tsum txiav txim siab los ntawm koj tus kws kho mob.

Tus neeg mob tshuaj xyuas txog Zokor

Cov tshuaj no thiab nws cov analogues tau pom los ntawm cov neeg mob yog cov txiaj ntsig zoo ntawm kev tiv thaiv pathologies ntawm CVS thiab kev kho mob ntawm hypercholesterolemia. Kev yooj yim ntawm kev siv cov tshuaj cais cais, feem ntau cov kws kho mob pom zoo kom noj ib zaug nyob rau ib hnub ntawm cov tshuaj, uas yooj yim pab tus neeg mob txoj kev siv tshuaj.

Peb tau soj ntsuam cov lus qhia rau kev siv nrog Zokor, tshuaj xyuas, ntxiv rau analogues rau nws.

Tsuas tshuaj thiab tswj hwm

Ua ntej thiab thaum kawg ntawm kev kho, kev noj zaub mov hypocholesterol yuav tsum ua raws cai. Sab hauv, thaum pib koob tshuaj 10 mg ib zaug, thaum yav tsaus ntuj, nrog qhov mob me me los sis me ntsis ntawm hypercholesterolemia, thawj qhov kev txiav txim yog 5 mg, yog tias tsim nyog, qhov koob tshuaj yog maj mam nce ntawm ncua sijhawm 4 lub lis piam. Nrog tsev neeg homozygous hypercholesterolemia, koob tshuaj txhua hnub yog 40 mg ib zaug, thaum yav tsaus ntuj lossis 80 mg / hnub (muab faib ua 3 koob - 20 mg thaum sawv ntxov, 20 mg thaum tav su, 40 mg thaum yav tsaus ntuj). Nrog rau cov kab mob plawv, thawj koob tshuaj yog 20 mg, ib zaug, thaum yav tsaus ntuj, yog tias tsim nyog, nws tau maj mam nce ntxiv ntawm ncua sijhawm 4 lub lis piam txog 80 mg.

Kev tiv thaiv kev nyab xeeb

Txee lub neej ntawm cov tshuaj Zokor®

10 mg zaj duab xis-coated ntsiav tshuaj - 3 xyoos.

zaj duab xis-coated ntsiav tshuaj 20 mg - 3 xyoos.

co ntsiav tshuaj 10 mg - 3 xyoos.

co ntsiav tshuaj 20 mg - 3 xyoos.

co ntsiav tshuaj 40 mg - 2 xyoos.

co ntsiav tshuaj 80 mg - 2 xyoos.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Cov lus qhia rau kev siv Zokora: txoj kev thiab ntau npaum li cas

Ua ntej pib siv Zokor, tus neeg mob tau sau tshuaj noj rau cov zaub mov hypocholesterol, uas yuav tsum pom thoob plaws hauv kev kho mob tag nrho.

Qhov koob tshuaj txhua hnub ntawm cov tshuaj (los ntawm 5 txog 80 mg) yuav tsum tau noj nyob rau hauv 1 koob tshuaj thaum yav tsaus ntuj.

Nyob rau lub sijhawm txhaj tshuaj rau rab koob tshuaj, nws nce ntau yam tsawg kawg 4 lis piam sib nrug. Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 80 mg.

Cov neeg mob uas muaj mob ua rau cov hlab ntshav tuag lossis muaj qhov pheej hmoo ntawm nws txoj kev loj hlob: 40 mg ib hnub ib zaug. Kev siv tshuaj kho pib ua ke nrog kev noj haus thiab kev tawm dag zog,
Cov neeg mob uas muaj hypercholesterolemia (tsis muaj kev pheej hmoo ntawm kev txhim kho mob plawv): pib koob - 20 mg ib hnub twg. Hauv qee kis (yog tias qhov kev txo qis hauv LDL los ntawm ntau dua 45% yuav tsum), ib qho pib ntawm 40 mg yuav tsum raug muab. Nrog cov mob me mus rau mob me ntawm qib hypercholesterolemia, kev kho mob tuaj yeem pib nrog kev noj tshuaj txhua hnub ntawm 10 mg, yog tias tsim nyog, nws tau maj mam nce,
Cov neeg mob nrog homozygous tsev neeg hypercholesterolemia: 40 mg ib hnub ib zaug lossis 80 mg hauv 3 faib koob tshuaj - 20 mg thaum sawv ntxov thiab yav tav su thiab 40 mg thaum yav tsaus ntuj.Hauv qhov no, Zokor tuaj yeem raug tshuaj los ua ib qho yeeb tshuaj lossis ntxiv rau lwm txoj hauv kev ntawm kev kho mob uas txo cov roj (piv txwv li LDL plasmapheresis).

Zokor yog siv los ua kev kho kab mob ntshav siab los yog siv tshuaj sib xyaw nrog cov kua tsib acid sequestrants. Hauv qhov no, yuav tau kho qhov kev hloov kho nyob ntawm cov tshuaj siv ua ke:

Danazole, cyclosporine, gemfibrozil, lwm yam fibrates (tshwj tsis yog fenofibrate), lipid-txo qis niacin (> 1000 mg / hnub): koob tshuaj txhua hnub ntawm Zokor yog 10 mg,
Verapamil, amiodarone: koob tshuaj txhua hnub yuav tsum tsis pub tshaj 20 mg.

Cov neeg mob uas mob raum tsis ua hauj lwm tsis tas yuav kho qhov koob. Cov neeg mob uas lub raum tsis ua haujlwm loj (kev tsim kho lub peev xwm tsis pub tsawg tshaj 30 ml / feeb) tsis pom zoo kom noj ntau tshaj li 10 mg ib zaug ib zaug. Yog tias qhov xav tau ntawd ncaj qha, kev kho mob yuav tsum tau ua nyob rau hauv kev saib xyuas mob nkeeg tshwj xeeb.

Analogs ntawm Zokor

Cov analogues ntawm cov tshuaj no yog cov tshuaj Simvastatin, Avestatin, Simvakard, Simlo, Atherostat, Levomir, Vabadin, Ib Sim Neej, Zovatin, Simvor.

Lawv muab cov txiaj ntsig zoo sib xws, tab sis tsuas yog tus kws tshaj lij yuav tsum txiav txim siab cov tshuaj zoo tshaj plaws hauv txhua kis.

Tsis muaj cov ntaub ntawv txaus ntsig txog kev siv cov tshuaj no rau menyuam yaus, yog li cov tshuaj no tsis raug siv los kho cov menyuam yaus hnub nyoog qis dua 10 xyoo.

Zokor tau siv coj los kho kho hom mob hterozygous ntawm hypercholesterolemia hauv cov hluas ntawm cov zaub mov noj. Raws li tshuaj ntawm cov yeeb yaj kiab, qib ntawm triglycerides, roj cholesterol, apolipoprotein B txo.

Kev kho mob ntawm cov menyuam ntxhais hluas nrog yeeb tshuaj yuav tau xyaum tsuas yog kev coj khaub ncaws hauv tus ntxhais hluas pib tsawg kawg yog ib xyoos dhau los.

Noj ntau dhau

Hauv ntau qhov muaj mob paub ntau tshaj plaws ntawm kev siv ntau tshaj (ntau kawg noj - 450 mg), tsis muaj cov tsos mob tshwj xeeb los yog muaj tej yam tshwm sim. Kev kho mob Symptomatic yog siv.

Kev tiv thaiv kev nyab xeeb

Cia rau cov mob ntawm cov tshuaj Zokor®

Nyob rau qhov kub thiab txias tsis tshaj 30 ° C.

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Txee lub neej ntawm cov tshuaj Zokor®

10 mg zaj duab xis-coated ntsiav tshuaj - 3 xyoos.

zaj duab xis-coated ntsiav tshuaj 20 mg - 3 xyoos.

co ntsiav tshuaj 10 mg - 3 xyoos.

co ntsiav tshuaj 20 mg - 3 xyoos.

co ntsiav tshuaj 40 mg - 2 xyoos.

co ntsiav tshuaj 80 mg - 2 xyoos.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated: oval, du rau ntawm ib sab, nyob rau lwm sab - engraving "MSD 735" (ntsiav tshuaj ntawm lub teeb liab xim) lossis engraving "MSD 740" (ntsiav tshuaj ntawm cov xim daj daj xim) (14 pcs. hlwv, 1 lossis 2 lub hlwv hauv ib pob ntawv hauv).

Cov tshuaj nquag muaj simvastatin:

1 ntsiav tshuaj ntawm lub teeb liab xim - 10 mg,
1 tan ntsiav tshuaj - 20 mg.

Cov kev zam: ascorbic acid, butylhydroxyanisole, microcrystalline cellulose, lactose monohydrate, pregelatinized hmoov txhuv nplej siab, citric acid, magnesium stearate.

Lub plhaub muaj pes tsawg leeg: hydroxypropyl cellulose, talc, methylhydroxypropyl cellulose, titanium dioxide, dyes hlau oxide daj thiab hlau oxide liab.

Pharmacological kev txiav txim

Raws li cov lus qhia, Zokor yog tus cwj pwm ntawm lub suab lipid-txo cov nyhuv. Cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog kev siv tshuaj simvastatin, uas, thaum hydrolyzed, hloov mus rau hauv cov khoom sib txuas. Nws cov khoom noj tshuaj tiv thaiv kab mob ua rau cov enzyme HMG-CoA reductase, uas koom nrog qhov kev pib biosynthesis ntawm roj.

Yog li ntawd, kev siv cov tshuaj yuav pab txo qis tag nrho cov roj hauv lub cev, nrog rau cov qib roj cholesterol ua ke nrog cov lipoproteins uas muaj tsawg thiab tsawg heev. Qhov concentration ntawm cov roj cholesterol nyob rau hauv ntshav ntawm triglycerides kuj txo.

Tib lub sijhawm, thaum noj Zokor, cov ntsiab lus ntawm cov roj (cholesterol) cuam tshuam nrog cov lipoproteins ntau ntom nce ntxiv. Cov tshuaj siv rau ntau hom hyperlipidemia, nrog rau tsev neeg tsis muaj tsev neeg, tsev neeg, kab mob siab. Nws kuj tseem raug sau tseg rau kev sib xyaw ua ke ntawm hyperlipidemia nyob rau hauv cov teeb meem no thaum siv cov khoom noj tsis tshua muaj peev xwm ua kom ib txwm tsis ua hauj lwm zoo ntawm cov lipids hauv cov ntshav.

Qib ntshav lipid yuav txo qis tau 14 hnub tom qab pib kho mob. Lawv cov lej nce mus txog tsawg kawg nkaus ntawm 4 - 6 lub lim tiam ntawm kev kho mob. Nrog kev tswj hwm ntxiv ntawm cov tshuaj, cov txiaj ntsig no tau tshwj tseg.

Tom qab ua tiav ntawm kev kho, qhov ntsuas ntawm tag nrho cov roj hauv plasma maj mam rov qab rau cov thawj zaug, uas tau txiav txim siab ua ntej pib siv tshuaj.

Pharmacodynamics thiab pharmacokinetics

Qhov siab tshaj plaws ntawm simvastatin metabolites hauv cov ntshav tau sau tseg 1.3-2.4 teev tom qab noj ib Zocor. Kwv yees li ntawm 85% ntawm cov tshuaj nquag muaj nyob rau hauv cov ntsiav tshuaj yog nqus rau hauv lub cev thaum noj ntawm qhov ncauj.

Thaum kho nrog tshuaj, qib siab ntawm simvastatin tau sau tseg hauv daim siab piv rau lwm cov ntaub so ntswg. Raws li "thawj kis" ntawm cov tshuaj los ntawm lub siab, nws yog metabolized, tom qab ntawd cov tshuaj nws tus kheej thiab nws cov metabolites tau tawm ntawm lub cev nrog cov kua tsib.

Txais ntawm Zokor tsis yog nyob ntawm kev siv khoom noj khoom haus, uas tsis cuam tshuam rau pharmacokinetics ntawm cov tshuaj. Kev kho ntev ntev tsis coj mus rau kev sib txuam ntawm simvastatin hauv cov nqaij mos ntawm lub cev.

Kev ntsuas rau siv

Zocor tau tshaj tawm rau cov neeg mob uas muaj mob plawv (CHD) lossis mob siab rau tus kabmob no, nrog rau cov neeg mob uas muaj kev pheej hmoo loj rau cov hlab plawv (nrog rau cov mob hyperlipidemia), piv txwv li, cov neeg mob ntshav qab zib mellitus, cov neeg mob peripheral vascular kab mob, mob hlab ntsha tawg lossis lwm yam kab mob cerebrovascular nyob rau hauv anamnesis. Lub hom phiaj ntawm tshuaj:

Txo txoj kev pheej hmoo ntawm lub neej tuag vim CHD,
Txo txoj kev pheej hmoo ntawm kev tsim mob hnyav rau lub plawv lossis cov hlab ntsha hnyav, xws li mob hlab ntsha tawg, tsis ua mob rau cov leeg ntshav tuag, mob ntshav tuag,
Txo txo txoj kev pheej hmoo hauv tsev kho mob rau mob hlwb nres,
Txo txoj kev pheej hmoo ntawm kev phais mob vim yog qhov xav tau rov ua kom ntshav ntws los ntshav lossis lwm yam kev tsis muaj mob.

Tsis tas li ntawd, mus rau cov npe hom ntawm cov neeg mob, cov tshuaj tau raug sau tseg yog tias nws yuav tsum ua txoj haujlwm ntawm kev hloov kho tshiab.

Tsis tas li ntawd, Zokor tau raug tshaj tawm rau hypercholesterolemia - raws li ib qho kev sib ntxiv rau kev noj zaub mov hauv qhov mob uas kev noj zaub mov tsis haum thiab lwm txoj kev siv tshuaj tsis raug ntawm kev kho mob tsis txaus. Lub hom phiaj ntawm tshuaj:

Kev kho mob ntawm hom IV hyperlipidemia raws li kev faib tawm ntawm Fredrickson (hypertriglyceridemia),
Kev kho mob ntawm hom mob thib III hyperlipidemia raws li kev faib tawm ntawm Fredrickson (dysbetalipoproteinemia),
Txo cov rog tag nrho, cov roj lipoprotein (LDL) roj tsawg, roj av apolipoprotein B thiab triglycerides,
Cov roj (cholesterol) ntau ntawm cov lipoproteins ntau (HDL) hauv cov neeg mob uas muaj ntshav siab, nrog rau hom IIa hyperlipidemia raws li kev faib tawm ntawm Fredrickson (heterozygous tsev neeg hypercholesterolemia) lossis hom II hyperlipidemia raws li kev faib tawm ntawm Fredrickson (sib xyaw hypercholesterolemia),
Txo cov kev sib piv ntawm cov roj (cholesterol) tag nrho rau HDL cov roj (cholesterol), thiab cov roj LDL roj txaus rau roj HDL,
Txo kom nce qib ntawm tag nrho cov roj (cholesterol), LDL cov roj (cholesterol) thiab apolipoprotein B hauv cov neeg mob homozygous tsev neeg hypercholesterolemia (ntxiv rau kev noj haus thiab lwm yam kev kho mob).

Hauv cov neeg mob uas mob ntshav qab zib mellitus, Zokor txo qhov kev pheej hmoo ntawm qhov pheej hmoo ua mob vascular keeb kwm (suav nrog qhov yuav ua rau mob qog nqaij, mob tawm tsam thiab txiav tawm ntawm sab qis).

Hauv cov neeg mob uas muaj mob plawv, nrog rau cov roj (cholesterol) siab, cov tshuaj muaj peev xwm txo qis kev pheej hmoo ntawm kev mob plawv coronary atherosclerosis, suav nrog cov tsos ntawm cov teeb meem thiab kev raug mob tshiab.

Cov Yuav Tsum Muaj

Kev pheej nce siab hauv cov theem ntawm hepatic transaminases hauv cov ntshav plasma ntawm cov neeg tsis paub dab tsi,
Mob siab daim siab,
Cev xeeb tub thiab lub sijhawm nws npaj,
Kab Mob Siab
Cov tib neeg lub siab ntev dhau mus rau cov tshuaj ntawm cov tshuaj.

Vim tias tsis muaj cov ntaub ntawv kev nyab xeeb txog kev siv simvastatin hauv kev kho mob pediatrics, nws tsis pom zoo kom sau cov tshuaj rau cov menyuam yaus.

Keeb kwm ntawm rhabdomyolysis,
Mob ntshav qab zib mellitus
Qhov kev nce qib ntawm cov ntshav hloov pauv (thaum muaj ntau dua tus cai ntawm 3 zaug, cov tshuaj tau muab tso tseg),
Mob raum tsis ua hauj lwm (kev tshem tawm creatinine tsawg dua 30 ml / min),
Cawv kev quav cawv.

Cov lus qhia rau kev siv Zokora: txoj kev thiab ntau npaum li cas

Ua ntej pib siv Zokor, tus neeg mob tau sau tshuaj noj rau cov zaub mov hypocholesterol, uas yuav tsum pom thoob plaws hauv kev kho mob tag nrho.

Qhov koob tshuaj txhua hnub ntawm cov tshuaj (los ntawm 5 txog 80 mg) yuav tsum tau noj nyob rau hauv 1 koob tshuaj thaum yav tsaus ntuj.

Nyob rau lub sijhawm txhaj tshuaj rau rab koob tshuaj, nws nce ntau yam tsawg kawg 4 lis piam sib nrug. Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 80 mg.

Cov neeg mob uas muaj mob ua rau cov hlab ntshav tuag lossis muaj qhov pheej hmoo ntawm nws txoj kev loj hlob: 40 mg ib hnub ib zaug. Kev siv tshuaj kho pib ua ke nrog kev noj haus thiab kev tawm dag zog,
Cov neeg mob uas muaj hypercholesterolemia (tsis muaj kev pheej hmoo ntawm kev txhim kho mob plawv): pib koob - 20 mg ib hnub twg. Hauv qee kis (yog tias qhov kev txo qis hauv LDL los ntawm ntau dua 45% yuav tsum), ib qho pib ntawm 40 mg yuav tsum raug muab. Nrog cov mob me mus rau mob me ntawm qib hypercholesterolemia, kev kho mob tuaj yeem pib nrog kev noj tshuaj txhua hnub ntawm 10 mg, yog tias tsim nyog, nws tau maj mam nce,
Cov neeg mob nrog homozygous tsev neeg hypercholesterolemia: 40 mg ib hnub ib zaug lossis 80 mg hauv 3 faib koob tshuaj - 20 mg thaum sawv ntxov thiab yav tav su thiab 40 mg thaum yav tsaus ntuj. Hauv qhov no, Zokor tuaj yeem raug tshuaj los ua ib qho yeeb tshuaj lossis ntxiv rau lwm txoj hauv kev ntawm kev kho mob uas txo cov roj (piv txwv li LDL plasmapheresis).

Zokor yog siv los ua kev kho kab mob ntshav siab los yog siv tshuaj sib xyaw nrog cov kua tsib acid acid ntxiv. Hauv qhov no, yuav tau kho qhov kev hloov kho nyob ntawm cov tshuaj siv ua ke:

Danazole, cyclosporine, gemfibrozil, lwm yam fibrates (tshwj tsis yog fenofibrate), lipid-txo qis niacin (> 1000 mg / hnub): koob tshuaj txhua hnub ntawm Zokor yog 10 mg,
Verapamil, amiodarone: koob tshuaj txhua hnub yuav tsum tsis pub tshaj 20 mg.

Sab sij huam

Cov kab mob hauv lub cev: dyspepsia (raws plab, xeev siab thiab ntuav), tsis tshua muaj - kab mob pancreatitis, daj ntseg, kab mob siab,
Nruab nrab hauv lub paj hlwb: vertigo, peripheral neuropathy,
Musculoskeletal system: myalgia, tsis tshua muaj mob rhabdomyolysis,
Kev ua xua thiab tiv thaiv kev tiv thaiv: lupus-zoo li mob ntsws, mob caj dab, mob caj dab, mob polymyalgia, mob rheumatism, nce ESR, eosinophilia, mob caj dab, thrombocytopenia, arthralgia, vasculitis, urticaria, tawv nqaij hyperemia, photosensitivity, ua tsis taus pa, ua tsis taus pa, dav dav
Dermatological tshua: ua pob rau daim tawv nqaij, khaus, dermatomyositis, alopecia,
Lwm yam: cov leeg nqaij pob txha, mob pob txha caj dab, dav dav mob, ntshav liab,
Kev ntsuas ntsuas: nce theem ntawm transaminases, alkaline phosphatase thiab gamma-glutamyl transpeptidase, creatine phosphokinase.

Noj ntau dhau

Thaum noj ntau dhau, txoj kev siv tshuaj ib txwm siv los kov yeej cov kev ua txhaum rau lub cev.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj yeeb yaj kiab hauv qab no siv ib txhij nrog simvastatin (tshwj xeeb tshaj yog nyob rau hauv koob tshuaj ntau) ua rau muaj kev pheej hmoo ntawm myopathy / rhabdomyolysis:

Muaj zog CYP3A4 inhibitors: clarithromycin, erythromycin, telithromycin, ketoconazole, nefazodone, itraconazole, tib neeg cov tshuaj tiv thaiv kab mob tiv thaiv kab mob protease inhibitors,
Lwm yam tshuaj lipid-txo qis uas tsis muaj zog inhibitors ntawm CYP3A4, tab sis uas tuaj yeem ua rau kev txhim kho myopathy: gemfibrozil thiab lwm yam fibrates (tshwj tsis yog fenofibrate), niacin (nicotinic acid) hauv lipid-txo cov koob tshuaj (> 1 g / hnub),
Cyclosporin, danazole,
Amiodarone, verapamil,
Diltiazem.

Simvastatin, siv nyob rau hauv ib koob tshuaj txhua hnub ntawm 20-40 mg, potentiates cov txiaj ntsig ntawm coumarin anticoagulants thiab ua rau muaj kev pheej hmoo los ntshav: prothrombin lub sijhawm (International Normalized Ratio) nce los ntawm thawj zaug ntawm 1.7 txog 1.8 hauv cov neeg tuaj yeem noj qab haus huv, thiab cov neeg mob hypercholesterolemia - los ntawm 2 , 6 txog 3.4. Txhawm rau tshem tawm cov kev hloov tseem ceeb hauv qhov ntsuas no, cov neeg mob tau txais kev pab coumarin anticoagulants, lub sijhawm prothrombin yuav tsum txiav txim siab ua ntej pib siv Zokor thiab tsis tseg thaum pib kev kho mob. Tom qab INR qhov ntsuas tsis ua hauj lwm lawm, nws qhov kev txiav txim siab ntxiv yuav tsum tau ua nyob rau ntawm cov kev ncua sij hawm pom zoo rau kev saib xyuas cov neeg mob niaj hnub ua kom zoo.

Cov kua txiv kab ntxwv kua txiv muaj tsawg kawg yog ib qho tivthaiv uas tiv thaiv CYP3A4 thiab tuaj yeem nce plasma ntau ntau ntawm cov tshuaj metabolized los ntawm cov enzyme no. Kev siv 1 khob kua txiv (250 ml) ib hnub tsis muaj qhov tseem ceeb rau lub chaw kuaj mob. Txawm li cas los xij, thaum haus cov kua txiv ntau (ntau dua 1 liter ib hnub) thaum lub sijhawm kho nrog simvastatin, qib ntshav ntawm kev ua haujlwm ntawm HMG-CoA reductase inhibitors ho nce ntxiv. Vim li no, kua txiv kab ntxwv qaub ntau yuav tsum tsis txhob haus thaum kho.

Cov cim ntawm Zokor yog: Simvastatin, Simvastatin Zentiva, Avestatin, Simvakard, Simlo, Aterostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Thaum cev xeeb tub thiab lactation

Kev siv cov tshuaj no yog contraindicated hauv lub sijhawm cev xeeb tub thiab pub mis rau menyuam noj noj niam mis. Thaum noj cov tshuaj simvastatin thaum cev xeeb tub, muaj qhov txawv txav hauv cov txheej txheem ntawm tus menyuam hauv plab.

Thaum lub sijhawm lactation, yog tias tsim nyog, thov Zokor, koj yuav tsum nres kev pub mis.

Kev txheeb xyuas txog Zokora

Cov kev txheeb xyuas ntau heev tau paub txog Zokora, lees tias qhov kev siv tshuaj. Nws cov khoom ua ub ua no yeej pab txo qis cov roj (cholesterol). Txawm li cas los xij, kom tau txais cov txiaj ntsig tau tshwm sim, nws raug nquahu kom siv cov tshuaj nruj me ntsis rau lub sijhawm txiav txim los ntawm tus kws kho mob koom nrog. Cov neeg mob qhia txog cov txiaj ntsig tau zoo thaum siv simvastatin ua ib txoj kev tiv thaiv.

Kev Sau ua ke, daim foos tso tawm

Zokor tawm hauv cov tshuaj coated ntsiav tshuaj. Lawv yog oval, txiv duaj (10 mg) lossis ziab (20 mg) hauv xim.

Ib Zocor ntsiav tshuaj muaj 10 lossis 20 mg ntawm simvastatin. Kev ua haujlwm pabcuam yog ua los ntawm: ascorbic acid, citric acid, butylhydroxyanisole E320, cellulose, hmoov txhuv nplej siab, magnesium stearate, mis qab zib. Lub plhaub pliav pliav muaj qhov hloov kho cellulose, hypromellose, titanium dioxide (E 171), talc, daj, liab hlau oxide (E172, E171).

Zokor: kev taw qhia rau kev siv

Raws li cov lus qhia, Zokor tau sau tseg rau cov neeg mob uas muaj keeb kwm lossis tau txais cov tshuaj hypercholesterolemia ntxiv rau kev noj zaub mov, thaum nws ib leeg tsis txaus rau:

txo qis hauv kev ua haujlwm ntawm OH, X-LDL, TG, apolipoprotein B,
nce rau hauv HDL-C rau hauv cov neeg mob uas muaj hom IIa / IIb hyperlipidemia,
txo qhov piv ntawm X-LDL / X-HDL, OH / X-HDL,
qis triglycerides.

Cov tshuaj Zokor tseem qhia tau rau cov neeg muaj kev pheej hmoo loj ntawm kev mob plawv: mob ntshav qab zib mellitus, mob hlab ntsha tawg lossis lwm yam kab mob cerebrovascular, mob hlab ntsha hlwb. Nquag cov metabolism hauv roj, nrog rau lwm cov rog rog, pab tiv thaiv kev txhim kho ntawm cov teeb meem.

Txoj kev ntawm daim ntawv thov, ntau npaum li cas

Zokor txoj kev kho yog tsuas yog tom qab ib chav ntawm kev kho kev noj haus tsom mus rau kev ua kom zoo cov roj (cholesterol). Cov txiaj ntsig tom qab ntawm cov ntsiav tshuaj yog nyob ntawm tus neeg mob lub txim. Yog tias nws tsis lo rau kev noj zaub mov, nws yuav raug txo kom xoom.

Qhov koob tshuaj txhua hnub ntawm Zokor yog 5-80 mg. Cov ntsiav tshuaj tau noj ib zaug / ib hnub, thaum yav tsaus ntuj, muaj dej txaus. Khoom noj tsis cuam tshuam rau kev nqus ntawm cov tshuaj. Yog li no, tsis tas yuav ua kom sib xyaw kev nkag los ntawm Zokor nrog zaub mov.

Lub sijhawm teem sijhawm ntawm cov tshuaj pib nrog kev noj tshuaj tsawg kawg, tuaj yeem soj ntsuam tom qab 28 hnub.

Cov neeg mob uas muaj lub plawv ischemic / muaj kev pheej hmoo siab ntawm nws txoj kev loj hlob, cov tshuaj yog sau tseg hauv thawj koob 40 mg / hnub. Rau lwm cov neeg mob hypercholesterolemia, cov tshuaj pib ntau yog 20 mg / hnub.

Nrog rau kev muaj keeb kwm ntawm kev mob ntshav qab zib cov roj ntsha tsis txaus, Zokor yog tshuaj ntawm 40 mg / hnub (ib zaug) lossis 80 mg / hnub (peb zaug: 20 mg thaum sawv ntxov, tav su, 30 yav tsaus ntuj).

Qhov ua tau ntawm kev muab tshuaj rau cov menyuam yaus 10-17 xyoo nrog kev mob ntshav siab yog qhov tsis txaus ntseeg. Hauv txoj kev tshawb no, ib pab pawg ntawm cov menyuam yaus tau coj Zokor rau 48 lub lis piam, thiab muab cov placebo thib ob. Muaj tsis muaj qhov sib txawv hauv kev tiv taus. Tab sis rau kev txiav txim siab tsis muaj tseeb, nws yog ib qho tsim nyog yuav tsum tau ua cov kev ntsuam xyuas ntev dua, txhawm rau tshuaj xyuas cov nyhuv ntawm cov tshuaj rau hauv kev xav, kev sib deev

1. Cov lus qhia rau kev siv

Noj Zokor yuav tsum nrog kev noj haus kom txo qis roj. Cov neeg mob tau raug xaj li 5 txog 80 mg ntawm cov tshuaj rau kev siv txhua hnub ua ntej yuav mus pw. Nws yog tsis yooj yim sua kom dhau qhov siab tshaj plaws kev coj ua. Cov koob tshuaj zoo tshaj plaws tau xaiv ib tus zuj zus, txhua qhov kev hloov pauv ntawm qhov kev pom zoo ntawm Zocor tau nqa tawm tsis ntau tshaj ib hlis ib zaug.

Cov kev kho mob yuav tsum tau siv sijhawm ntev, thaum cov tshuaj raug rho tawm, tus neeg mob rov qab mus rau nws lub xeev qub.

Kev noj cov tshuaj rau ntau hom kab mob feem ntau yog li hauv qab no:

Ischemic mob plawv, ntshav qab zib mellitus, mob stroke - 40 mg txhua hnub, tib lub sijhawm, koj yuav tsum ua raws li kev noj zaub mov noj thiab koom nrog kev kawm hauv lub plawv,
Hypercholesterolemia - nrog rau daim ntawv me me ntawm tus kab mob, 10-20 mg yog tau sau tseg rau txhua yav tsaus ntuj yog tias nws yuav tsum tau txhaj cov qib LDL tsawg dua 45% –40 mg,
Tsev neeg hypercholesterolemia - nws raug pom zoo kom pib kho nrog 40 mg ntawm cov tshuaj nyob rau yav tsaus ntuj lossis 80 mg peb zaug ib hnub (20 + 20 + 40 nyob rau tib lub sijhawm sib nrug).

Yog tias Zokor tau sau ua ke nrog Danazol, Cyclosporin, Gemfibrozil thiab lwm yam fibrates lossis Niacin, qhov siab tshaj plaws txhua hnub yuav tsum tsis pub dhau 10 mg.

Ua ke nrog Verapamil lossis Amiodarone, tus nqi no yog 20 mg. Cov neeg mob uas mob raum tsis zoo txaus raug pom zoo kom txwv txhua hnub rau 10 mg.

3. Siv cov khoom muaj nuj nqis

Zokor yog tshuaj rau cov neeg mob uas muaj lub plawv ischemic lossis cov kev xav ua ntej rau tus kabmob no, hypercholesterolemia ua ntau hom, thiab mob ntshav qab zib mellitus.

Cov tshuaj muaj cov khoom nram qab no:

tawm tsam nrog cov tsos mob ntawm ischemic mob plawv,
txo txoj kev pheej hmoo ntawm txoj kev tuag vim los ntawm cov kab mob plawv,
tiv thaiv kev txhim kho ntawm cov mob hnyav vascular-mob caj dab (mob hlab ntsha tawg, mob plawv nres, thiab lwm yam),
txo qhov kev xav tau rov ua haujlwm ntawm lub cev thiab lwm yam kev ntshav khiav,
tsis muaj zog angina tawm tsam,
txo qis tag nrho cov roj (cholesterol), LDL thiab B-lipoprotein,
nce HDL (cov roj (cholesterol) zoo),
tswj cov qib triglyceride ntau ntau.

Ntawm cov mob ntshav qab zib mellitus, Zokor tiv thaiv qhov pom ntawm kev raug mob hauv hlab ntsha peripheral, thiab nyob rau hauv rooj plaub ntawm mob hlab ntsha hlwb thiab hypercholesterolemia ua ke nws qeeb ntawm kev txhim kho mob rau lub plawv atherosclerosis thiab lwm yam teeb meem.