Diabetalong - cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Cov lus qhia rau kev siv:

Cov nqi hauv cov khw muag tshuaj hauv online:

Diabetalong yog ib qho muab tso ntawm sulfonylurea ntawm lub cim thib ob, yog ib qho tshuaj hypoglycemic rau kev tswj hwm qhov ncauj.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv koob tshuaj - muaj kev txhawb nqa cov ntsiav tshuaj (60 mg) thiab hloov cov ntsiav tshuaj tso tawm (30 mg): tiaj-cylindrical, yuav luag dawb lossis dawb, nrog lub ntsej muag, marbling raug tso cai, 60 mg ntsiav tshuaj tiaj, nrog cov kab sib cais (hauv contour xov tooj ntim khoom: 60 mg ib qho - 10 pcs., hauv daim ntawv qhwv ib pob 1, 2, 3 lossis 6 pob, 20 pcs., hauv ib pob ntawv 1 pob, 3, 5 lossis 6 pob, 30 mg - 10 pcs., hauv daim ntawv thawv ntawm daim npav 3 lossis 6 pob khoom).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: gliclazide - 60 mg lossis 30 mg,
Cov khoom siv pabcuam: aerosil (colloidal silicon dioxide), calcium stearate, 80 ntsiav tshuaj (lactose monohydrate), hypromellose (Metocel K-100 LV CR Hwm), talc.

Tsis tas li ntawd, hauv cov ntsiav tshuaj nrog rau kev tso tawm ntev hauv cov muaj pes tsawg leeg ntawm hypromellose - Metolosa 90 SH-100SH.

Kev ntsuas rau siv

Kev siv Diabetalong yog qhia rau kev kho mob hom 2 mob ntshav qab zib mellitus thaum tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo, ua kom lub cev thiab yuag poob.

Ib qho ntxiv, cov ntsiav tshuaj tso tawm ntev ntev tau sau los kho kev tiv thaiv kev mob ntshav qab zib mellitus hauv kev txiav txim siab txhawm rau txo kev pheej hmoo ntawm kev txhim kho retinopathy, nephropathy, myocardial infarction, mob hlab ntsha los ntawm kev sib ntxiv glycemic tswj nyob rau hauv hom 2 mob ntshav qab zib.

Cov Yuav Tsum Muaj

ntshav qab zib hom 1
ketoacidosis, mob ntshav qab zib precoma, mob ntshav qab zib coma,
kho kev txawj ntse nrog miconazole,
Hepatic thiab / lossis lub raum tsis ua haujlwm,
cev xeeb tub lub sijhawm
pub niam mis
hnub nyoog txog 18 xyoo
lactase deficiency, qabzib-galactose malabsorption syndrome, lactose tsis haum,
kev siv tib lub sijhawm phenylbutazone lossis danazole,
muaj tshuaj tso rau sulfonamides, lwm yam sulfonylurea derivatives, tshuaj hauv tshuaj.

Nrog kev ceev faj, nws yog ib qho tsim nyog yuav tsum tau sau ntawv rau Diabetalong rau cov neeg mob uas tsis muaj zaub mov noj tsis txaus thiab / lossis tsis ntsuas nws lub cev, tsis muaj cov piam thaj-6-phosphate dehydrogenase, cov kab mob hnyav ntawm cov hlab plawv (nrog rau mob plawv, atherosclerosis), hypopituitarism, hypothyroidism, adrenal tsis txaus lossis / lossis lub siab ua haujlwm tsis zoo, siv sijhawm ntev mus ntev ntawm glucocorticosteroids, kev txom nyem los ntawm kev quav dej caw, thaum laus.

Tsuas tshuaj thiab tswj hwm

Cov ntsiav tshuaj tau noj ntawm qhov ncauj, nqos tag nrho, zoo dua thaum noj tshais, 1 zaug hauv ib hnub.

Cov koob tshuaj ntawm cov tshuaj yuav tsum tau txiav txim siab los ntawm kev xaiv, noj mus rau hauv tus account ib leeg lub siab ntawm cov kua nplaum thiab glycosylated hemoglobin hauv cov ntshav.

1 ntsiav tshuaj ntawm 60 mg yog sib npaug rau cov nyhuv kho ntawm 2 ntsiav tshuaj ntawm 30 mg. Sib cais ntawm kev pheej hmoo ntawm cov ntsiav tshuaj ntawm 60 mg tso cai, yog tias tsim nyog, faib nws ua ob seem. Yog tias, qhov txiaj ntsig ntawm kev faib, ib nrab ntawm cov ntsiav tshuaj tau tawg, nws yuav tsum tsis txhob ua.

Cov tshuaj pom zoo txhua hnub: cov koob tshuaj thawj zaug (suav nrog cov neeg mob hnub nyoog tshaj 65) yog 30 mg, nrog cov lus teb txaus nws yog siv raws li kev tswj xyuas txij nkawm. Thaum tsis muaj cov tshuaj glycemic txaus, cov tshuaj txhua hnub yuav tsum ua ntu zus (tsis pub ntau tshaj 1 zaug hauv 4 lub lis piam) nce mus rau 60, 90 lossis 120 mg. Yog tias qhov txo qis hauv kev ua hauj lwm ntawm cov piam thaj hauv cov ntshav tsis tshwm sim tom qab 2 lub lis piam ntawm kev noj cov ntsiav tshuaj, tom qab ntawd cov koob tshuaj tau nce ntxiv li ntawm 2 lub lis piam.

Tsis txhob noj ntau dua tom qab txav ib koob lossis ntau dua koob tshuaj.

Qhov siab tshaj plaws niaj hnub noj yog 120 mg.

Thaum hloov los ntawm lwm tus neeg saib xyuas tus mob hypoglycemic hauv qhov ncauj, nws cov koob tshuaj thiab ib nrab ntawm lub neej yuav tsum raug coj los txiav txim.

Yog tias cov khoom lag luam dhau los ntawm sulfonylurea derivatives muaj lub sijhawm ntev li ib nrab-lub neej, nws raug nquahu kom mus so hauv kev noj ob peb zaug ua ntej noj cov tshuaj. Qhov no yuav zam dhau qhov hypoglycemia tawm tsam keeb kwm ntawm qhov tshwm sim ntxiv ntawm ob tus kab mob ntshav siab. Hauv ob peb lub lis piam, yuav tsum ua tib zoo saib xyuas cov ntshav ntshav qabzib.

Thawj koob tshuaj Diabetalong yuav tsum tau ib txwm yog 30 mg.

Cov ntsiav tshuaj tau qhia nyob rau hauv kev sib xyaw nrog hypoglycemic tus neeg sawv cev xws li biguanides, alpha glucosidase inhibitors lossis insulin.

Cov neeg mob raum tsis txaus ntawm qhov mob me me mus rau mob hnyav tau tshaj tawm txoj kev noj ib txwm ntawm cov tshuaj, tab sis kev kho yuav tsum tau ua raws li kev saib xyuas mob nkeeg.

Vim tias cov neeg mob uas tsis muaj zaub mov tsis txaus los sis tsis muaj nyiaj txaus, mob hnyav los yog ua tsis zoo rau cov mob endocrine (hypothyroidism, pituitary thiab adrenal tsis txaus), cov kab mob loj ntawm cov hlab plawv (kev mob plawv, feem ntau atherosclerosis, carotid arteriosclerosis) lossis tom qab kev kho mus sij hawm ntev thiab / lossis kev kho mob hauv kev txhaj tshuaj ntau dua, glucocorticosteroids yog qhov muaj pheej hmoo los ntawm kev mob ntshav qab zib, lawv yuav tsum tau txiav txim siab tsis pub tshaj 30 mg ntawm cov tshuaj ib hnub.

Txhawm rau tiv thaiv cov kev mob ntshav qab zib mellitus thaum lub sijhawm siv cov tshuaj, cov neeg mob yuav tsum ua raws li kev noj haus uas kws kho mob pom zoo, ua kev tawm dag zog lub cev, thiab yog tias qhov xwm txheej tsis zoo, sab laj nrog kws kho mob tam sim ntawd.

Sab sij huam

kev txhim kho hypoglycemia: cov tsos mob - kev tshaib nqhis heev, tawm hws, tsis muaj zog, txhav tawv nqaij, mob taub hau, xeev siab, ntuav, nce nkees, txob taus, pw tsaug zog, ntxhov siab, qeeb teb, poob siab, poob siab, tsis pom kev thiab hais lus, tsis meej pem , aphasia, tshee tshee, zoo li tsis paub pab lwm tus, paresis, plam ntawm kev tswj tus kheej, lub siab tsis hnov qab, kiv taub hau, tsaug zog, bradycardia, delirium, ua tsis taus pa, ua pa, ntxhov siab, tachycardia, nce ntshav tawm siab, arrhythmia, angina pectoris, palpitations, poob nco qab, tsis nco qab, tuag,
los ntawm lub plab zom mov: xeev siab, ntuav, mob plab, raws plab, cem quav,
dermatological tshua: khaus, tawv nqaij ua pob, urticaria, erythema, Quincke's edema, maculopapular pob, mob ua paug rau daim tawv nqaij ua kom tsis haum, Stevens-Johnson syndrome,
los ntawm cov kab mob ntshav hematopoietic plab hnyuv siab raum thiab lymphatic: hloov pauv hematological - leukopenia, ntshav liab, thrombocytopenia, granulocytopenia,
los ntawm cov kab mob hepatobiliary: nce kev ua si ntawm alkaline phosphatase, aspartate aminotransferase (ACT), alanine aminotransferase (ALT), hauv qee kis tsawg - kab mob siab, cholestatic daj ntseg,
los ntawm cov kabmob hauv nruab nrog: hloov ua kom pom kev txawv txav (ntau zaus thaum pib kho),
lwm yam: muaj peev xwm (cov kev mob tshwm sim rau sulfonylurea derivatives) - mob siab rau lub siab tsis ua hauj lwm, agranulocytosis, erythrocytopenia, mob ntshav qab zib (hemolytic anemia), kev tsis haum vasculitis, pancytopenia, hyponatremia.

Cov lus qhia tshwj xeeb

Tawm tsam keeb kwm yav dhau los ntawm kev siv Diabetalong, zoo li lwm yam sulfonylurea derivatives, muaj kev pheej hmoo ntawm hypoglycemia. Txhawm rau kom tso tseg nws cov tsos mob, tus neeg mob yuav tsum noj tam sim ntawd txhua yam khoom muaj carbohydrate (suab thaj tuaj yeem ua), qab zib hloov hauv qhov no tsis zoo.

Nyob rau hauv cov ntaub ntawv ntawm cov mob hnyav thiab lub sijhawm ntev ntawm lub qog ntshav qab zib, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob thiab tso ntshav tshuaj ntawm cov tshuaj dextrose rau ob peb hnub.

Thaum sau daim ntawv yuav tshuaj, tus neeg mob thiab nws tsev neeg yuav tsum paub kom meej txog qhov yuav tsum tau ua raws li cov pluas noj tsis tu ncua, suav nrog kev noj tshais, kev phom sij thiab cov tsos mob ntawm tus mob ntshav qab zib, nrog rau cov xwm txheej zoo rau nws txoj kev txhim kho. Txij li thaum cov lus tsis txaus, noj zaub mov tsis txaus los yog noj zaub mov tsis hnov qab los yog ua rau muaj kev phom sij, nws yog qhov tseem ceeb heev uas ua raws txhua tus kws kho mob cov lus pom zoo.

Ntxiv rau kev noj zaub mov kom lub cev tsis zoo, cov ntshav qab zib hauv lub cev feem ntau tshwm sim los ntawm kev ua kom lub cev muaj zog lossis ua kom lub cev muaj zog, haus dej haus cawv, lossis noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm.

Nws yuav tsum tau yug hauv siab lub peev xwm los ntawm kev tsim cov kev rov qab los ntawm hypoglycemia tom qab kev vam meej pib ntawm nws.

Cov xwm txheej hauv qab no cuam tshuam rau qhov kev pheej hmoo ntawm hypoglycemia:

tus neeg mob tsis kam lees lossis tsis muaj peev xwm (feem ntau muaj hnub nyoog laus dua) tswj hwm nws tus mob thiab ua raws li kws kho mob cov lus qhia,
tsis ua raws kev tswj hwm thiab noj haus,
ua txhaum ntawm kev tshuav ntawm kev sib txig ntawm cov carbohydrates thiab kev siv lub cev,
ib txhij siv cov tshuaj uas txhim kho cov nyhuv hypoglycemic ntawm cov tshuaj,
daim siab ua hauj lwm hnyav
lub raum tsis ua hauj lwm
pathology ntawm cov thyroid caj pas, adrenal thiab pituitary tsis txaus,
overdose ntawm Ntshav Qab Zib.

Cov kev hloov pauv ntawm cov chaw muag tshuaj thiab / lossis cov chaw muag tshuaj ntawm gliclazide nyob rau hauv cov neeg mob raum thiab hepatic tsis txaus ua rau muaj qhov tsis zoo rau qhov mob ntawm hypoglycemia ntau nyob rau hauv qhov xwm txheej ntawm nws txoj kev txhim kho.

Nws raug nquahu kom noj cov tshuaj nrog kev tswj xyuas tus kheej ntawm cov ntshav qabzib hauv siab.

Nrog lub cev tsis muaj cov piam thaj-6-phosphate dehydrogenase, cov tshuaj tuaj yeem pab txhawb kev txhim kho hemolytic anemia, yog li nws pom zoo kom xav txog kev muaj peev xwm ntawm kev sau tshuaj hypoglycemic tus neeg ntawm lwm pab pawg.

Yog tias muaj kev kis mob lossis kev phais loj, yuav tsum tau txais kev txiav txim siab kom ua tiav qhov kev kho tshuaj thiab kev teem caij kho tshuaj insulin.

Qhov laj thawj ntawm kev nyiam ua rau qhov txo qis ntawm cov ntshav qab zib hauv lub cev ntshav qab zib muaj ntshav qab zib tom qab siv sijhawm ntev yuav yog ob qho kev txo qis hauv kev kho tus mob thiab qhov mob ntawm tus mob. Thaum kuaj pom tias cov tshuaj tiv thaiv ua haujlwm tsis tseem ceeb thib ob, tus kws kho mob yuav tsum ua tib zoo saib xyuas qhov tsis txaus ntawm cov tshuaj uas tus neeg mob tau noj thiab nco ntsoov tias nws ua raws li kev noj tshuaj uas tau noj.

Noj cov tshuaj thaum noj tshais txo txoj kev pheej hmoo ntawm kev phiv los ntawm cov hnyuv plab.

Hauv daim siab hnyav thiab / lossis lub raum tsis ua haujlwm, tus neeg mob raug nquahu kom siv cov insulin.

Thaum npaj kev cev xeeb tub lossis thaum muaj menyuam hauv plab thaum noj tshuaj, tus poj niam raug nquahu kom hloov mus rau tshuaj insulin.

Muab cov kev pheej hmoo ntawm hypoglycemia, cov neeg mob tau qhia kom ua kev xyuam xim thaum tsav tsheb thiab cov txheej txheem thaum siv cov tshuaj.

Yeeb tshuaj sib cuam tshuam

Nrog tib lub sijhawm siv ntawm Diabetalong:

miconazole ua rau txhim kho cov nyhuv ntawm gliclazide,
nrog cov kev tswj hwm ntawm kev tswj hwm, phenylbutazone txhawb qhov hloov chaw ntawm gliclazide los ntawm nws lub koom haum nrog cov ntshav plasma protein thiab / lossis qeeb nws qhov kev tshem tawm los ntawm lub cev, nce hauv cov nyhuv hypoglycemic ntawm cov tshuaj,
ethanol (suav nrog cawv thiab tshuaj muaj cawv nrog) ua rau muaj kev pheej hmoo ntawm hypoglycemia, tuaj yeem ua rau mob hypoglycemic,
lwm cov kab mob hypoglycemic (insulin, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, glucagon-zoo li peptide-1 receptor agonists), beta-blockers, fluconazole, angiotensin-hloov enzyme inhibitors (captopril, blocktopril), ectop₂- histamine receptors, monoamine oxidase inhibitors, sulfonamides, clarithromycin, cov tshuaj tsis-steroidal los tiv thaiv cov tshuaj tiv thaiv - nce cov nyhuv hypoglycemic ntawm cov tshuaj thiab qhov kev pheej hmoo ntawm hypoglycemia,
Danazole muaj qhov ua rau mob ntshav qab zib, txo qhov kev soj ntsuam cov tshuaj,
Chlorpromazine nyob rau hauv ib koob tshuaj saum toj 100 mg ib hnub twg, txo qis kev zais ntawm cov tshuaj insulin, nce qhov nce ntawm cov piam thaj hauv cov ntshav,
tetracosactides thiab glucocorticosteroids rau kev siv tshuaj thiab siv tshuaj muaj zog ua kom cov concentration ntawm cov piam thaj hauv cov ntshav, tuaj yeem txo qhov kev ua kom tsis haum siab thiab ua rau ketoacidosis,
salbutamol, ritodrin, terbutaline rau kev tswj hwm ntshav ua rau kom muaj ntau ntxiv cov piam thaj hauv cov ntshav,
warfarin thiab lwm yam tshuaj thaiv cov kab mob tuaj yeem txhim kho lawv cov nyhuv.

Diabetalong analogues yog: Diabinax, Gliclazide MV, Gliclazide-Akos, Glidiab MV, Diabeton MV, Glucostabil.

Pharmacological kev txiav txim

Kev siv tshuaj qhov ncauj hypoglycemic, ib qho sulfonylurea derivative ntawm lub cim thib ob.

Nws ua rau lub cev muaj zog ntawm cov insulin los ntawm tus txiav, txo qis ntawm cov piam thaj hauv cov ntshav, ua rau cov insulin-secretory zoo li ntawm cov piam thaj thiab ua rau muaj kev cuam tshuam ntawm cov ntaub so ntswg mus rau insulin. Tom qab 2 xyoos ntawm kev kho mob, feem ntau cov neeg mob tsis txhim kho kev quav yeeb tshuaj (nce qib ntawm cov tshuaj insprico tom qab thiab kev zais C-peptides tseem nyob).

Txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov kom pib lub insulin secretion. Nws rov qab pib lub ncov thaum ntxov ntawm insulin secretion hauv kev teb rau cov piam thaj (tsis zoo li lwm yam sulfonylurea derivatives, uas muaj qhov cuam tshuam tshwj xeeb tshaj yog nyob rau theem thib ob ntawm kev zais cia). Nws tseem ua kom zoo dua theem thib ob ntawm kev tsim cov tshuaj insulin. Txo cov ncov ntawm hyperglycemia tom qab noj mov (txo qis postprandial hyperglycemia).

Glyclazide ntau ntxiv qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin (i.e., muaj cov lus hais ntxiv ua kom zoo ntxiv). Hauv cov leeg nqaij, cov nyhuv ntawm cov tshuaj insulin rau ntawm cov piam thaj, vim muaj cov ntaub so ntswg hloov pauv mus rau insulin, tau nce ntau (nce txog + 35%), txij li glycazide stimulates cov kev ua ntawm cov leeg glycogen synthetase.

Txo kev tsim cov piam thaj hauv lub siab, ua haujlwm li qub ceev ceev cov piam thaj.

Ntxiv rau kev cuam tshuam rau cov metabolism hauv cov metabolism, gliclazide txhim kho microcirculation. Cov tshuaj txo txoj kev pheej hmoo ntawm cov ntshav me me rau cov ntshav thrombosis, cuam tshuam rau ob lub tswv yim uas yuav koom nrog kev txhim kho cov teeb meem hauv cov ntshav qab zib mellitus: ib feem ntawm kev txwv tsis pub platelet thiab kev sib dhos thiab ib qho kev txo qis hauv cov concentration ntawm platelet ua kom muaj feem (beta-thromboglobulin, thromboxane B2), nrog rau kev rov qab fibrinolytic kev ua haujlwm ntawm vascular endothelium thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Glyclazide muaj cov khoom ua antioxidant: nws txo cov ntshav lipid peroxides hauv ntshav, nce qhov kev ua haujlwm ntawm cov ntshav liab ntshav superoxide dismutase.

Vim tias qhov peculiarities ntawm daim ntawv tshuaj, cov tshuaj txhua hnub ntawm Diabetalong ® 30 mg ntsiav tshuaj muab cov tshuaj kho zoo ntawm gliclazide hauv cov ntshav ntshav 24 teev.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, gliclazide yog kiag li nqus los ntawm cov hnyuv. Kev noj tsis cuam tshuam rau kev nqus. Qhov kev kub siab ntawm cov tshuaj nquag hauv cov ntshav plasma nce ntau zuj zus, nce mus txog qhov siab thiab nce mus txog toj siab 6-12 teev tom qab noj cov tshuaj. Kev hloov pauv ntawm tus kheej yog qhov tsawg. Cov kev sib raug zoo ntawm cov koob tshuaj thiab kev saib xyuas ntawm cov tshuaj hauv ntshav ntshav yog txoj kab tso siab raws lub sijhawm.

Kev faib khoom thiab cov metabolism

Plasma protein khi yog kwv yees li 95%.

Nws yog cov tshuaj nyob rau hauv daim siab thiab ua rau feem ntau yog ua los ntawm lub raum. Tsis muaj cov metabolites hauv lub plasma ntshav.

Kev zam los ntawm ob lub raum yog ua tiav rau feem ntau ntawm kev tsim cov tshuaj metabolites, tsawg dua 1% ntawm cov tshuaj yog tawm tsis pauv.

T 1/2 yog li ntawm 16 teev (12 txog 20 teev).

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv cov neeg laus, tsis muaj qhov tshwj xeeb hauv kev kho mob hauv qhov kev hloov pharmacokinetic.

Kev noj tshuaj ntxiv

Cov tshuaj yog npaj rau kev kho mob ntawm cov neeg laus xwb.

Diabetalong ® 30 mg hloov-tso tawm ntsiav tshuaj noj noj ntawm ncauj 1 zaug / hnub thaum noj tshais.

Rau cov neeg mob uas tsis tau txais kev kho yav tas los (suav nrog rau cov neeg laus dua 65 xyoo), qhov pib tshuaj yog 30 mg. Tom qab ntawd cov koob tshuaj tau xaiv ib tus zuj zus kom txog thaum qhov txiaj ntsig kho tau tiav.

Kev xaiv koob tshuaj yuav tsum tau ua tiav raws li theem ntawm cov piam thaj hauv cov ntshav tom qab pib kev kho mob. Txhua qhov hloov pauv koob tshuaj tom qab tuaj yeem ua tom qab tsawg kawg ob lub lim tiam.

Qhov koob tshuaj txhua hnub tuaj yeem hloov los ntawm 30 mg (1 tab.) Txog 90-120 mg (3-4 tab.). Qhov tshuaj txhua hnub yuav tsum tsis pub ntau tshaj 120 mg (4 ntsiav tshuaj).

Diabetalong ® tuaj yeem hloov cov tshuaj gliclazide qis dua li niaj hnub (80 mg) hauv 1 txog 4 ntsiav tshuaj / hnub.

Yog tias koj plam ib lossis ntau dua ntawm cov tshuaj, koj tsis tuaj yeem noj ntau dua ntawm qhov koob tshuaj ntxiv (hnub tom qab).

Thaum hloov lwm cov tshuaj hypoglycemic nrog Diabetalong ® 30 mg ntsiav tshuaj, tsis muaj lub sijhawm hloov pauv ntawm lub sijhawm. Koj yuav tsum xub tsum tsis txhob noj cov tshuaj ntawm txhua hnub thiab tsuas yog hnub tom qab pib noj cov tshuaj no.

Yog tias tus neeg mob tau txais kev kho mob yav dhau los nrog sulfonylureas nrog ntev dua ib nrab-lub neej, tom qab ntawd ceev faj saib xyuas (saib xyuas ntshav qabzib) rau 1-2 lub lis piam yog qhov tsim nyog kom tsis txhob mob ntshav qab zib ua qhov tsis muaj txiaj ntsig ntawm qhov seem ntawm cov kev kho mob dhau los.

Diabetalong ® tuaj yeem siv nrog kev sib xyaw nrog loj loj, alpha-glucosidase inhibitors lossis insulin.

Hauv cov neeg mob uas mob mentsis mus txog rau lub raum lub raum tsis ua hauj lwm, cov tshuaj no tau sau tseg rau tib lub sijhawm ib yam li cov neeg mob uas lub raum tsis ua haujlwm. Hauv kev mob raum tsis ua haujlwm, Diabetalong ® yog contraindicated.

Hauv cov neeg mob uas muaj kev pheej hmoo txhim kho hypoglycemia (kev noj zaub mov tsis txaus lossis tsis txaus noj, cov mob hnyav lossis cov neeg ua haujlwm tsis txaus ua rau cov leeg endocrine - pituitary thiab adrenal tsis txaus, hypothyroidism, tshem tawm cov glucocorticosteroids tom qab siv sijhawm ntev thiab / lossis kev tswj hwm siab ntau ntxiv), cov kab mob hnyav ntawm cov hlab plawv / Cov tshuaj tiv thaiv kab mob rau hauv IHD hnyav, mob hnyav carotid arteriosclerosis, mob atherosclerosis /) nws raug nquahu kom siv cov koob tshuaj tsawg kawg (30 mg 1 teev / hnub) ntawm cov tshuaj Diabetalong ®.

Sab sij huam

Cov Hypoglycemia (ua txhaum rau txoj kev noj tshuaj ntau thiab noj tsis txaus): mob taub hau, qaug zog ntau, tshaib plab, tawm hws, mob tsis muaj zog, palpitations, arrhythmia, nce ntshav siab, tsaug zog, insomnia, ntxhov siab, ntxhov siab, ntxhov siab, chim siab, tsis hnov qab, tsis tuaj yeem ua kom pom tseeb thiab ncua sijhawm tshuaj tiv thaiv, kev nyuaj siab, tsis pom kev, tsis meej pem, tshee hnyo, paresis, hnov lub siab tsis sib xws, kiv taub hau, zoo li tsis muaj kev cia siab, tsis tuaj yeem tswj tau tus kheej, delirium, convulsions, dag e ua pa, bradycardia, hnovqab, coma.

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, mob plab, cem quav (qhov mob ntawm cov tsos mob no tsawg dua thaum noj nrog zaub mov), tsis tshua muaj - lub siab ua haujlwm tsis ua haujlwm (kab mob siab, nce kev ua haujlwm ntawm hepatic transaminases, alkaline phosphatase, cholestatic jaundice - yuav tsum tau tshem tawm tshuaj).

Los ntawm cov ntshav hemopoietic plab hnyuv siab raum: inhibition ntawm pob txha mob hematopoiesis (mob ntshav qab zib, thrombocytopenia, leukopenia, granulocytopenia).

Kev ua xua: ua pob khaus tawv, tso zis, tso pob khaus, ua pob maculopapular thiab bullous), erythema.

Lwm yam: tsis pom kev pom.

Cov kev mob tshwm sim ntawm sulfonylurea derivatives: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, kev tsis haum vasculitis, ua rau lub siab ua rau lub siab tsis ua haujlwm.

Cev xeeb tub thiab lactation

Tsis muaj kev paub nrog gliclazide thaum cev xeeb tub. Cov ntaub ntawv hais txog kev siv lwm cov sulfonylurea derivatives thaum cev xeeb tub muaj tsawg.

Hauv kev kawm txog cov tsiaj hauv chaw sim, teratogenic cov teebmeem ntawm gliclazide tsis tau txheeb xyuas.

Txhawm rau kom txo cov kev pheej hmoo ntawm lub cev tsis xwm yeem, kev tswj hwm qib siab (kev kho kom haum) ntawm ntshav qab zib mellitus yog qhov tsim nyog.

Qhov ncauj hypoglycemic qhov ncauj thaum cev xeeb tub tsis siv. Cov tshuaj ntawm cov kev xaiv rau kev kho mob ntshav qab zib hauv cov poj niam cev xeeb tub yog cov tshuaj insulin. Nws raug nquahu kom hloov qhov kev noj tshuaj ntawm qhov ncauj hypoglycemic nrog insulin txoj kev kho ob leeg nyob rau hauv rooj plaub ntawm kev npaj cev xeeb tub, thiab yog tias cev xeeb tub tau tshwm sim thaum noj cov tshuaj.

Ua rau hauv kev txiav txim siab tsis muaj cov ntaub ntawv hais txog kev noj cov gliclazide hauv cov kua mis thiab kev pheej hmoo ntawm kev noj qab haus huv neonatal hypoglycemia, kev pub mis niam yog contraindicated thaum kho cov tshuaj.

Noj ntau dhau

Cov tsos mob: hypoglycemia, hnov lus tsis zoo, mob ntshav qab zib tsis tsaug zog.

Kev Kho Mob: yog tias tus neeg mob nco qab, noj qab zib sab hauv.

Tej zaum qhov kev txhim kho ntawm cov kev mob hypoglycemic hnyav, nrog kev tsis nco qab, ntog lossis lwm yam mob puas siab ntsws. Yog tias cov tsos mob no tshwm sim, yuav tsum tau txais kev kho mob ceev ceev thiab tau mus pw hauv tsev kho mob sai.

Yog tias hypoglycemic coma yog xav tias yog lossis kuaj mob, 50 ml ntawm 40% dextrose (kua nplaum) daws tau nrawm nrawm rau hauv tus neeg mob. Tom qab ntawd, 5% dextrose (piam thaj) cov tshuaj tov yog muab tshuaj rau kom tswj tau qhov qib uas yuav tsum muaj piam thaj hauv ntshav.

Tom qab nws rov qab nco qab, nws yog ib qho tsim nyog yuav tsum muab cov neeg mob cov zaub mov nplua nuj nyob hauv cov khoom noj zom zaub mov kom yooj yim (kom tsis txhob rov qab txhim kho hypoglycemia). Kev ua tib zoo soj ntsuam cov ntshav qabzib hauv qib siab thiab soj ntsuam ntawm tus neeg mob yuav tsum tau nqa tawm tsawg kawg 48 teev tom qab. Tom qab lub sijhawm no, nyob ntawm tus neeg mob lub sijhawm, tus kws kho mob txiav txim siab txog qhov xav tau kev tshuaj xyuas ntxiv.

Kev lim ntshav tsis muaj txiaj ntsig vim yog qhov tseeb khi ntawm gliclazide ntxiv rau cov ntshav protein.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ntsiav tshuaj - 1 ntsiav tshuaj:

Cov tshuaj lom neeg: glyclazide - 30 mg, Cov muaj mob: hypromellose (Metocel K-100 LV CR Hwm), colloidal silicon dioxide (aerosil), calcium stearate, talc, lactose monohydrate (80 ntsiav tshuaj).

Tus neeg sawv cev ntawm tus mob ntshav qab zib ntau ntau, yog sulfonylurea derivative ntawm lub cim thib ob. Pab tsim lub cev kom zais cov kua ntshav los ntawm β-hlwb ntawm cov txiav. Tsub qhov rhiab heev ntawm peripheral cov ntaub so ntswg rau insulin. Thaj, nws pab txhawb kev ua si ntawm intracellular enzymes (hauv tshwj xeeb, nqaij glycogen synthetase). Txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov kom pib lub insulin secretion. Rov kho lub sijhawm thaum ntxov ntawm insulin secretion, txo qis ncov tom qab ntawm hyperglycemia.

Glyclazide txo cov platelet adhesion thiab kev sib sau, maj mam txo qis kev txhim kho ntawm parietal thrombus, thiab nce vascular fibrinolytic kev ua si. Normalizes vascular permeability. Nws muaj cov khoom ua rau anti-atherogenic: nws txo qis cov roj (Ch) thiab LDL-C hauv cov ntshav, nce qhov nce ntawm HDL-C thiab kuj txo cov dawb radicals. Tiv thaiv kev txhim kho ntawm microthrombosis thiab atherosclerosis. Txhim kho microcirculation. Txo kom vascular rhiab heev rau adrenaline.

Nrog rau cov ntshav qab zib nephropathy nrog kev siv lub sijhawm ntev ntawm gliclazide, qhov tseem ceeb txo qis rau cov proteinuria tau sau tseg.

Tom qab kev tswj hwm ntawm qhov ncauj, nws nrawm los ntawm lub plab zom mov. C max hauv cov ntshav tau mus txog kwv yees li 4 teev tom qab noj ib koob ntawm 80 mg.

Plasma protein khi yog 94.2%. V d - txog 25 l (0.35 l / kg lub cev hnyav).

Nws yog metabolized hauv lub siab nrog kev tsim ntawm 8 metabolites. Lub ntsiab metabolite tsis muaj qhov teebmeem hypoglycemic, tab sis muaj cov nyhuv ntawm microcirculation.

T1 / 2-12 teev .Nws yog txau feem ntau los ntawm lub raum ua cov tshuaj metabolites, tsawg dua 1% yog tawm hauv cov zis tsis hloov pauv.

Tshuaj qhov ncauj hypoglycemic.

Gliclazide yog siv los kho cov ntshav qab zib tsis yog-insulin nyob rau hauv kev sib xyaw nrog kev noj zaub mov kom muaj calorie tsawg, noj cov zaub mov qis.

Thaum kho, koj yuav tsum tau soj qab xyuas kom cov qib ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab tom qab noj mov, kev hloov pauv txhua hnub nyob hauv qib qabzib.

Kev phais mob lossis kev decompensation ntawm ntshav qab zib mellitus, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv tus account qhov tau los ntawm kev siv tshuaj insulin.

Nrog rau kev txhim kho cov ntshav qog ntshav qab zib, yog tias tus neeg mob nco qab, qabzib (lossis kua qab zib) yog tshuaj hauv. Yog tias tsis nco qab, tso ntshav qabzib lossis glucagon sc, intramuscularly lossis intravenously raug tswj hwm. Tom qab nws rov qab nco qab, nws yog ib qho tsim nyog yuav tsum tau muab cov neeg mob zaub mov nplua nuj nyob hauv cov carbohydrates kom tsis txhob rov qab txhim kho kev mob ntshav qab zib.

Nrog rau kev siv kev sib txuas ntawm gliclazide nrog verapamil, yuav tsum tau saib xyuas cov ntshav qabzib ntau ntxiv, nrog acarbose, ua tib zoo saib xyuas thiab kho cov tshuaj regimen ntawm hypoglycemic tus neeg sawv cev yog qhov yuav tsum tau ua.

Kev siv ua ke ntawm gliclazide thiab cimetidine tsis pom zoo.

Qhov Kev Txhawb Nqa Tawm, 30 mg

Ib ntsiav tshuaj muaj

cov tshuaj yeeb tshuaj yog gliclazide - 30 mg,

tus zam: hypromellose, colloidal silicon dioxide, calcium stearate, talc, lactose monohydrate

Cov ntsiav tshuaj yog dawb los yog yuav luag dawb, tiaj-cylindrical, muaj ib tug bevel. Lub xub ntiag ntawm "marbling" raug tso cai

Cov chaw muag tshuaj

Tom qab kev tswj hwm ntawm qhov ncauj, gliclazide yog kiag li nqus los ntawm txoj hnyuv hauv lub plab. Kev noj tsis cuam tshuam rau kev nqus. Qhov kev kub siab ntawm cov tshuaj nquag hauv cov ntshav plasma nce ntau zuj zus, nce mus txog qhov siab thiab nce mus txog toj siab 6-12 teev tom qab noj cov tshuaj. Kev hloov pauv ntawm tus kheej yog qhov tsawg. Cov kev sib raug zoo ntawm cov koob tshuaj thiab kev saib xyuas ntawm cov tshuaj hauv ntshav ntshav yog txoj kab tso siab raws lub sijhawm.

Kev sib txuas lus nrog cov protein ntshav yog kwv yees li 95%.

Nws yog cov tshuaj nyob rau hauv daim siab thiab ua rau feem ntau yog ua los ntawm lub raum. Kev zam los ntawm ob lub raum yog ua tiav rau feem ntau ntawm kev tsim cov tshuaj metabolites, tsawg dua 1% ntawm cov tshuaj yog tawm tsis pauv.

Tsis muaj cov metabolites hauv lub plasma ntshav. Ib nrab-lub neej yog kwv yees li 16 teev (12 txog 20 teev).

Hauv cov neeg laus, tsis muaj qhov tshwj xeeb hauv kev kho mob hauv qhov kev hloov pharmacokinetic.

Diabetalong ® yog qhov ncauj ntshav hypoglycemic tus neeg sawv cev, sulfonylurea derivative ntawm lub cim thib ob.

Txo kev tsim cov piam thaj hauv lub siab, ua haujlwm li qub ceev ceev cov piam thaj.

Ntxiv rau kev cuam tshuam rau cov metabolism hauv cov metabolism, gliclazide txhim kho microcirculation. Cov tshuaj txo txoj kev pheej hmoo ntawm cov hlab ntsha me me, cuam tshuam rau ob lub tswv yim uas yuav koom nrog kev txhim kho cov teeb meem hauv cov ntshav qab zib mellitus: ib feem ntawm kev txwv tsis pub platelet thiab kev sib dhos thiab ib qho kev txo qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B2), nrog rau kev kho rov qab ntawm fibrinolytic vascular endothelial kev ua si thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Glyclazide muaj cov khoom ua antioxidant: nws txo cov ntshav lipid peroxides hauv ntshav, nce qhov kev ua haujlwm ntawm cov ntshav liab ntshav superoxide dismutase.

Vim tias qhov peculiarities ntawm daim ntawv tshuaj, cov tshuaj txhua hnub ntawm Diabetalong® 30 mg ntsiav tshuaj muab cov tshuaj kho tau zoo ntawm gliclazide hauv cov ntshav ntshav rau 24 teev.

Kev Sau ua ke, daim foos tso tawm

Diabetalong muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb puag ncig. Lawv tau ntim rau hauv cov hlwv ntawm 10 daim thiab ib daim npav cardboard, qhov twg tuaj yeem los ntawm 3 txog 6 daim hlau.

Cov tshuaj muaj nyob hauv ob qhov tshuaj: 30 mg thiab 60 mg ntawm cov tshuaj nquag, uas yog gliclazide.

Ntu ntu ntawm cov tshuaj:

colloidal silicon dioxide,
lactose monohydrate,
calcium stearate
pyromellose
talcum hmoov.

Daim ntawv ntau npaum li cas yuav yog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog hloov kho tso tawm lossis nrog rau lub sijhawm ua haujlwm ntev.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Cov khoom siv tseem ceeb yog gliclazide, los ntawm cov khoom siv tshuaj lom neeg nws yog ib qho kev tso tawm ntawm lub cim thib ob ntawm sulfonylurea. Gliclazide tso rau pom cov kev ua haujlwm siab thiab kev nyab xeeb.

Nws tiv taus ntau hom kev lom neeg thiab muaj cov teebmeem hauv qab no:

nce kev lag luam ntawm tus kheej insulin, tso cai rau koj kom txo tau qhov tshuaj ntawm cov tshuaj hormone rau txhaj,
normalizes metabolism hauv carbohydrate,
nce cov kev ua ntawm pancreatic beta hlwb,
txo cov theem ntawm platelet fusion, uas txwv tsis pub thrombosis thiab lwm yam vascular pathologies.

Diabetalong yog kiag li nqus tom qab kev tswj hwm. Maj mam mus ntxiv hauv cov ntshav, nce mus txog qhov siab tshaj plaws 4-6 teev tom qab kev tswj hwm, qhia nws cov nyhuv rau 10-12 teev, tom qab ntawd nws cov concentration poob qis thiab tom qab 12 teev tshuaj raug tshem tawm ntawm lub cev.

Gliclazide yog metabolized feem ntau los ntawm daim siab, thiab tawm los ntawm lub raum.

Kev taw qhia thiab contraindications

Qhov laj thawj ntawm kev noj ntshav qab zib yog kev kuaj mob ntawm tus neeg mob - hom ntshav qab zib 2. Cov tshuaj raug txwv kom txo cov ntshav qab zib thaum ua raws li cov lus qhia txog kev noj zaub mov tsis zoo pab.

Tsis tas li, cov tshuaj yog kws kho raws li prophylactic rau cov kev mob tshwm sim los ntawm ntshav qab zib mellitus, feem ntau hloov pauv hauv cov qauv ntawm cov hlab ntsha nyob rau hauv tus ntawm glycemia siab.

Muaj cov qauv sib txuam rau cov tshuaj, lawv suav nrog:

ntshav qab zib hom 1
noj miconazole,
hepatic thiab lub raum tsis ua haujlwm,
lub sijhawm cev xeeb tub thiab pub niam mis,
muaj cov ketoacidosis uas mob ntshav qab zib, tsis nco qab lossis ua ntej lawm,
siab rhiab rau cov uas ua cov yeeb tshuaj,
ua txhaum ntawm cov lactose metabolism,
hnub nyoog mus deev.

Xyuam xim thiab tsuas yog nyob rau hauv kev saib xyuas ntawm tus kws kho mob, cov tshuaj yog siv:

thaum laus
cov neeg uas lawv cov zaub mov tsis xwm yeem,
cov neeg mob plawv txhab,
cov neeg mob uas mob ntshav qabzib-6-phosphate dehydrogenase tsis txaus,
tom qab lub sijhawm ntev ntawm glucocorticosteroid txoj kev kho,
quav cawv quav cawv
muaj raum lossis mob siab.

Hauv qhov no, tus kws kho mob yuav tsum txiav txim siab txog qhov teem caij raws li cov ntaub ntawv muaj.

Cov khoom siv video los ntawm tus kws muab tshuaj:

Cov lus qhia rau kev siv

Kev noj tshuaj ntau npaum li cas thiab kev siv Diabetalong yog kws kho mob muab los ntawm tus kws kho mob, lawv nyob ntawm tus kheej qhov tsis sib xws ntawm tus neeg mob thiab tuaj yeem sib txawv ntawm ib tus neeg mus rau lwm tus.Raws li cov lus qhia, kev txais tos yog ua tiav 1-2 zaug hauv ib hnub rau 20 feeb ua ntej noj mov. Txoj kev no yuav siv tau zoo tshaj ntawm cov khoom ntawm gliclazide.

Cov tshuaj tau noj ntawm qhov ncauj thiab ntxuav nrog me me ntawm cov dej. Cov koob tshuaj yog txiav txim siab los ntawm txoj kev xaiv. Hauv qhov no, koj yuav tsum pib nrog 30 mg rau ib hnub, yog tias tsis muaj ib qho kev kho kom zoo, qhov tshuaj tsuas yog maj mam nce los ntawm 30 mg rau 120 mg. Qhov no yog qhov siab tshaj plaws saum toj no uas kev siv tsis raug pom zoo.

Koj tsis tuaj yeem nce ntxiv qhov ntau ntxiv yog tias ib qho ntawm cov hau kev tau ua tsis tiav, vim tias cov tshuaj ua rau txo cov ntshav qab zib, uas tuaj yeem ua rau cov ntshav qab zib tsawg.

Cov neeg mob tshwj xeeb

Rau cov neeg laus dua 65 xyoos, yuav tsum tau muab tshuaj kho kom ntau dua. Feem ntau, cov tshuaj siv los ua raws li tib txoj cai.

Hauv lub sijhawm ntawm kev xeeb tub, cov tshuaj tau pom zoo kom hloov los ntawm kev siv tshuaj insulin kom txog thaum yug menyuam. Tsis muaj kev paub dhau los ntawm kev siv Diabetalong thiab lwm yam tshuaj glycoside thaum cev xeeb tub, yog li nws tsis muaj peev xwm txiav txim siab nws cov nyhuv ntawm cov menyuam hauv plab.

Thaum lub sijhawm lactation, cov tshuaj tseem tsis tuaj yeem siv, vim tias muaj qhov tshwm sim ntawm kev mob ntshav siab neonatal hypoglycemia hauv menyuam yaus. Yog li, pub niam mis rau tus pojniam uas mob tau raug txwv.

Cov neeg mob raum tsis ua haujlwm thiab lwm cov kab mob yuav tsum ua raws li cov tshuaj noj qis, tseem ceeb tshaj, yuav tsum tau saib xyuas txhua lub sijhawm ntawm tus kws kho mob.

Kev cuam tshuam nrog lwm yam tshuaj

Diabetalong nquag sib cuam tshuam nrog ntau yam tshuaj yeeb tshuaj, yog li ua ntej koj pib noj nws, koj yuav tsum paub koj tus kheej nrog qhov zoo tshaj no.

Yog li, thaum muaj kev tswj hwm tib lub sijhawm:

nrog cov cawv yuav ua rau lub ntsej muag hypoglycemia,
nrog Danazol, kev ua kom mob ntshav qab zib yog ua kom pom, uas txo cov nyhuv ntawm cov tshuaj,
nrog miconazole, cov nyhuv ntawm gliclazide ua kom zoo dua, uas tuaj yeem pab txhawb kev tsim cov ntshav hauv lub cev, qhov zoo ib yam tshwm sim nrog lwm cov kab mob hypoglycemic,
nrog chlorpromazine, uas txo cov kev tsim tawm ntawm cov tshuaj insulin, cov tshuaj ntawm cov tshuaj tseem ceeb txo,
nrog tetracosactide thiab glucocorticosteroids tuaj yeem ua rau muaj kev txhim kho ketoacidosis thiab txo qis hauv kev ua kom tau cov carbohydrate,
nrog Wafarin thiab lwm coagulants txhim kho nws cov nyhuv.

Kev tshuaj xyuas ntawm cov kws kho mob pom tias Diabetalong ua tau zoo tshaj plaws hauv kev txo qis ntshav qab zib, txawm li cas los xij, nws tsis tuaj yeem siv tas li.

Hauv qhov no, cov kab mob analogues ntawm Diabetalong tau muab tshuaj, uas muaj ntau heev:

Diabetalong thiab Diabeton tau tsim nyob rau hauv cov khoom siv tib yam, tab sis cov tshuaj thib ob yog pom tias qhov ua tau zoo dua, vim tias qhov tshwm sim ntawm nws cov kev ua tiav tiav sai dua, tab sis tus nqi ntawm cov tshuaj no yog 2 zaug siab dua. Glyclazide yog ib qho yuav luag tiav.

Glucophage ntev muaj metformin hauv nws cov lus sib xyaw thiab tuaj yeem ua ke nrog insulin thiab lwm yam tshuaj los txo cov ntshav qab zib.