Vazilip, Lavxias analogues ntawm cov tshuaj nrog cov nqi thiab tshuaj xyuas

- thawj hypercholesterolemia ntawm hom IIa thiab IIb, suav nrog polygenic hypercholesterolemia, kab mob heterozygous kab mob hypercholesterolemia thiab sib xyaw hyperlipidemia. Cov tshuaj no yog siv los kho mob hauv cov teeb meem thaum kev noj zaub mov noj thiab lwm txoj hauv kev kho tau tsis txaus.

- txo qis kev mob plawv thiab tuag rau cov neeg mob uas tau soj ntsuam cov kab mob atherosclerotic kab mob plawv lossis ntshav qab zib, nrog cov roj lossis ntshav nce siab thiab ua ib qho kev ntsuas ntxiv los kho lwm yam kev phom sij thiab kev kho plawv.

Sib tham txog cov tshuaj Vasilip hauv cov ntaub ntawv ntawm cov niam

Cov. Tformin txhim kho cov fibrinolytic yam ntxwv ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor. "G hais tias cov roj (cholesterol) yuav tsum tsawg dua. Yog tias nws tsis txo, ces Vasilip. Kuv kuj muaj ntshav ntau - hemoglobin-154. Kuv twb hnyav tawm ntawm cov ntsiav tshuaj.

Cov. Yog tias koj noj Oksilik txoj kev nyuaj, nws tsis txo nws ntau, tab sis koj muaj lub sijhawm sim l-thyroxine Metformin tau raug tshaj tawm rau koj kom ua kom sai rau cov khoom noj carbohydrate metabolism thiab qabzib siv, koj cov lus hais txog Vasilip yog kev lees paub tias cov tshuaj no tsis cuam tshuam rau lawv tus kheej - qhov no yog qhov kev paub ntawm tus kheej. Vasilip tsis pab kuv ib qho hlo li - Kuv haus Roxer rau 3 lub hlis. Cov txheej txheem ntawm cokes, zoo li yarins, jannins thiab dianes, tsuas yog ua rau koj lub zes qe menyuam, tab sis tsis cuam tshuam rau LH siab, txawm hais tias prolactin tsis zoo rau koj, (txhais tau tias ntau heev)) ) Utrozhestan yuav tsum tau haus cawv kom xwm yeem thiab tsis tsum yog tias tsim nyog ib qho, tsis yog ob qho. vitamins yog tas li nyob rau thawj theem ntawm glutamic acid peb zaug hauv ib hnub ntawm ntsiav tshuaj ntawm 5 txog 15 DC + ntawv ci + iodine, thiab txij li 16 txog 2.

2. Cov Kev Tiv Thaiv Sab Nraud

Raws li cov lus qhia, vasilip yog contraindicated hauv:

• ntau cov kab mob siab nyob hauv theem nquag,
• nce kev ua haujlwm ntawm daim siab transaminases ntawm cov tsis paub keeb kwm,
• concomitant siv vasilip thiab inhibitors,
• lub cev tsis haum xeeb rau cov feem uas ua yeeb tshuaj,
• cev xeeb tub.

Ceev faj yog qhia kom siv cov tshuaj nyob rau hauv cov mob hauv qab no:

• nyob rau hauv muaj keeb kwm ntawm daim siab mob siab,
• nrog kev ua txhaum loj ntawm cov tshuaj endocrine,
• nrog cov teeb meem metabolic
• nrog cov mob hnyav, piv txwv li, nrog sepsis,
• nrog arterial hypotension (siab saum toj no tsim muaj),
• nrog kev raug mob thiab doog ntshav ntawm ntau lub hauv paus,
• nrog rau daim ntawv tsis tswj hwm ntawm tus mob vwm,
• nrog myopathy (lub npe hu ua mob ntev, tsis tu ncua cov leeg mob, uas cov metabolism hauv cov leeg nqaij yog qhov tsis taus),
• thaum cov kev pab cuam phais mob,
• nrog kev haus dej cawv.

3. Sab sij hawm

Vasilip muaj peev xwm siv dhau qhov kev tsis txaus siab nyob rau hauv tib neeg lub cev, qhov feem ntau ntawm cov no yog:

Kev mob ntshav liab, mob raum tsis ua haujlwm, palpitations, kev ua haujlwm tsawg tsawg yog qhov tsawg.

4. Txoj kev ntawm kev tswj hwm tshuaj

Vasilip noj ntawm qhov ncauj, thiab cov koob tshuaj tuaj yeem tsim raws li qhov ntsuas thiab qhov ntsuas ntawm tus kab mob ntawm 5 txog 80 mg (qhov siab tshaj plaws ntawm cov tshuaj yog siv los kho mob hypercholesterolemia ntau heev lossis nyob rau qhov muaj qhov pheej hmoo siab muaj teeb meem hauv kev ua haujlwm ntawm kev ua haujlwm ntawm cov hlab plawv.

Lub sijhawm sijhawm ntawm kev pub nkag yog muab rau tus kheej los ntawm tus kws khomob. Qhov koob tshuaj qub yog 10 mg ntawm ib koob tshuaj txhua hnub, thiab raws li kev qhia tshwj xeeb tshaj tawm cov koob tshuaj no tau nce 2-8 zaug.

Hloov qhov koob tshuaj tsis pub ntau tshaj 1 zaug hauv ib hlis.

5. Kev sib txuam tshuaj

1. Cov tshuaj no tuaj yeem txhim kho qhov txiaj ntsig ntawm kev tiv thaiv tsis tau, uas tuaj yeem ua rau ntshav los.
2. Nws nce tsub kom lub siab ntawm Digoxin nyob rau hauv cov ntshav, yog li ntawd, cov neeg mob uas tau kho zoo li no yuav tsum tau saib xyuas los ntawm cov kws kho mob.

Ib txhij tswj hwm nrog cytostatics thiab antifungal cov neeg sawv cev (Ketoconazole, Itraconazole), fibrates, siab ntawm cov nicotinic acid, immunosuppressants, protease inhibitors tseem nce siab txaus ntshai txoj kev loj hlob ntawm rhabdomyolysis.

6. Tsuav tshaj

Muaj qee tus neeg mob tshaj qhov koob tshuaj Vasilip, txawm li cas los xij, lawv tsis ua rau muaj kev rau txim loj thiab ua txhaum loj. Dua li ntawm qhov no, yog tias muaj tshuaj ntau dhau, nws yog ib qho tsim nyog yuav tsum tau noj cov tshuaj kom nkag mus thiab yaug lub plab, thiab kev saib xyuas ntawm lub cev ua haujlwm yog pom zoo, tshwj xeeb tshaj yog rau lub raum thiab mob siab.

7. Tso daim ntawv thiab txee lub neej

Cov tshuaj yog tsim los ntawm kev lag luam kws kho mob hauv daim ntawv ntawm cov ntsiav tshuaj uas muaj cov yeeb yaj kiab-pleev xim rau sab nraud.

Ib ntsiav tshuaj tuaj yeem yog qhov sib txawv ntau npaum - 10 mg, 20 mg, 40 mg.

Hauv pob - 14 lossis 28 pieces.

Lub txee lub neej ntawm Vasilip yog 3 xyoos.

Cov tshuaj analogues rau cov tshuaj Vasilip:

Hauv cov khw muag tshuaj network, cov tshuaj tau muag ntawm tus nqi hauv qab no (nyob ntawm lub qhov koob):

• nyob rau hauv Russia - los ntawm 328 txog 587 rubles,
• nyob rau hauv Ukraine - los ntawm 82 rau 148 hryvnias.

Cov neeg mob uas tau noj cov tshuaj no tau sau tseg txog qhov txo cov ntshav hauv cov ntshav siab, ua kom tsis haum rau tus mob, thiab kev ncua ntev ntawm cov tshuaj.

Txawm li cas los xij, qhov no qhia tau hais tias qhov kev tsis txaus siab uas tsis xav paub txog cov kev mob tshwm sim uas ploj tom qab kawg noj Wazilip. Koj tuaj yeem nyeem cov ncauj lus kom ntxaws kev tshuaj xyuas cov neeg mob uas siv Vazilip tom kawg ntawm kab lus.

11. Cov lus qhia tshwj xeeb

1. Ua ntej pib txoj kev kho mob nrog Vazilip, koj yuav tsum ua qhov kev kuaj sim ntawm lub siab ua haujlwm qhov ntsuas thiab ntxiv saib xyuas cov haujlwm ntawm daim siab hloov ntshav txhua 1.5-2 lub hlis. Cov neeg mob uas tau txais simvastatin txhua hnub ntawm qhov siab tshaj (80 mg) feem ntau raug soj ntsuam rau lub siab ua haujlwm - ib zaug txhua peb lub hlis. Nrog rau kev nce ntxiv hauv kev ua ntawm transaminases, Vasilip txoj kev kho yog tso tseg.
2. Cov neeg mob nrog myasthenia gravis, myalgia, lossis nrog cov cim nce kev ua si ntawm CPK txoj kev kho nrog cov tshuaj hauv cov lus nug yuav tsum nres.
3. Simvastatin tsis pom zoo yog tias muaj kev pheej hmoo ntawm rhabdomyolysis lossis mob raum (vim yog mob ntshav tawm ntshav, mob hnyav, mob hnyav, cuam tshuam ntawm lub cev, ua rau raug mob).
4. Cov Cheebtsam ntawm Vasilip tawm tsam tsis zoo rau kev loj hlob ntawm tus me nyuam hauv plab, yog li ntawd, cov tshuaj yuav tsum raug cais tawm rau kev kho mob ntawm poj niam cev xeeb tub. Yog tias cev xeeb tub tshwm sim thaum kho nrog Vazilip, tom qab ntawd cov tshuaj yuav tsum tau nres.
5. Cov tshuaj no ua tau zoo rau hauv kev kho mob thiab tshuaj nrog cov tshuaj tiv thaiv cov kua tsib kua tsib.
6. Ib qhov mob tseem ceeb rau Kev Kho Mob Vasilip yog tus neeg mob noj zaub mov roj.
7. Yog tias qhov tam sim no ploj lawm, koj yuav tsum tau noj tshuaj ntxiv txuas ntxiv kom sai li sai tau yam tsis muaj ob zaug ntxiv.
8. Yog tias tsis tuaj yeem hnov ​​mob hauv cov leeg, tus neeg mob tau nquahu kom nrog kws kho mob sai.

Pharmacological kev txiav txim ntawm cov tshuaj

Cov tshuaj tseem ceeb ntawm Vasilip muaj cov roj lipid-txo qis thiab txo cov roj cholesterol hauv cov ntshav ntshav. Cov tshuaj no ua tau zoo rau kev mob plawv coronary, vim nws txo qis txaus ntshai myocardial infarction. Kev kho mob kom zoo dua ntawm kev siv vasilip tshwm sim ntau lub sijhawm ntawm ob lub lis piam, thiab qhov siab tshaj plaws tshwm sim tom qab ib hlis ntawm kev siv txhua hnub.

Tsis tas li ntawd, Vasilip, raws li kev txheeb xyuas, kuj muaj cov nyhuv los tiv thaiv atherosclerotic, muaj feem xyuam rau cov cheebtsam ntawm cov ntshav thiab cov hlab ntsha.

Dab tsi hauv daim ntawv tsim tawm

Vasilip yog muaj nyob rau hauv daim ntawv dawb-zaj duab xis-ntsiav tshuaj muaj 10, 20 thiab 40 mg ntawm cov tshuaj nquag simvastatin. 7 Ntsiav tshuaj ib lub hlwv.

Yog tias tsim nyog, cov tshuaj tuaj yeem hloov nrog ib qho ntawm cov yeeb yaj kiab ntawm Vazilip - simplacor, avestatin, holvasim, atherostat, simvakard, actalipid, zokor, simgal, vasilip, zorstat, aries, simvor, simvagheksal, simvalimit, simvastatin, simlo, sincard lossis zovatin.

Thaum koj tsis tuaj yeem teem caij

Raws li cov lus qhia, Vasilip yog contraindicated rau kev siv nrog:

• Cov kab mob siab nyob hauv theem nquag, nrog rau kev nce ntxiv hauv cov dej num ntawm hepatic transaminases ntawm kev tsis paub tus mob etiology,
• Kev tswj hwm ib txhij nrog cov tshuaj tiv thaiv kab mob CYP3A4 isoenzyme, suav nrog erythromycin, itraconazole, clarithromycin, ketoconazole, HIV protease inhibitors, nefazodone thiab telithromycin,
• Hypersensitivity rau lub Cheebtsam ntawm Vasilip.

Tsis tas li, cov tshuaj, zoo li Vazilip analogues, yuav tsum tsis txhob siv thaum cev xeeb tub, hnub nyoog qis dua 18 xyoo, thaum lactation, thaum npaj lub cev xeeb tub lossis yog xav tias tsam.

Vasilip yog siv nrog ceev faj hauv:

• Keeb kwm ntawm kab mob siab,
• Kev mob rau endocrine thiab metabolism ntxiv,
• Muaj mob hnyav, suav nrog sepsis,
• Cov leeg ntshav siab,
• Raug mob
• Tswjhwm mob qaug dab peg,
• Myopathy
• Kev phais mob sab nrauv,
• Kev haus cawv, tshwj xeeb ua ntej pib txoj kev kho,
• Lactase tsis muaj zog
• Loj tsis txaus electrolyte tsis txaus,
• Galactosemia los yog glucose-galactose malabsorption syndrome,
• Ib txhij tswj hwm nrog cyclosporine, fenofibrate, gemfibrozin, verapamil, nicotinic acid, amiodarone, diltiazem thiab kua txiv kab ntxwv qaub.

Txoj kev ntawm daim ntawv thov ntawm vasilip

Raws li cov lus qhia, Vasilip noj ntawm qhov ncauj ib zaug thaum yav tsaus ntuj, qhov koob tshuaj nyob ntawm tus kab mob tuaj yeem sib txawv ntawm 5 mg txog qhov siab kawg ntawm 80 mg, uas noj tsuas yog mob hnyav hypercholesterolemia lossis muaj kev pheej hmoo siab mob plawv. Lub sijhawm ntawm kev siv vasilip yog txiav txim siab ntawm tus kheej los ntawm tus kws khomob mus koom.

Feem ntau, hauv kev kho mob hypercholesterolemia, Vasilip noj 10 mg ib zaug, raws li kev qhia, qhov kev kho tshuaj tuaj yeem nce ntxiv 2 lossis 4 zaug. Raws li kev txheeb xyuas, Vasilip siv tau zoo thaum soj ntsuam ib qho kev ntsuas hypocholesterol nyob thoob plaws lub sijhawm kho.

Nrog homozygous kab mob siab mob hypercholesterolemia, Vasilip raug muab 40 mg ib zaug thaum yav tsaus ntuj lossis 80 mg ntawm cov tshuaj, muab faib ua 3 koob tshuaj, ua ke nrog lwm txoj kev kho mob hypolipidemic.

Nrog txoj kev pheej hmoo siab ntawm kev txhim kho cov hlab plawv, Vasilip noj 20-40 mg rau ib hnub ua raws li cov lus qhia. Koj tuaj yeem hloov cov koob tshuaj tsis ntau tshaj ib hlis ib zaug.

Raws li kev txheeb xyuas, Vasilip muaj txiaj ntsig zoo hauv kev kho mob monotherapy thiab hauv kev sib xyaw nrog colestyramine, amiodarone, colestipol, gemfibrozil, cyclosporine thiab lwm yam fibrates lossis nicotinic acid.

Thaum siv Vasilip, nws tsis pom zoo kom haus ib qho ntau (ntau dua 1 liter) ntawm cov kua txiv kab ntxwv qaub.

Phiv los sis vasilip

Raws li kev txheeb xyuas, Vasilip tsis feem ntau ua rau kev txhim kho kev mob tshwm sim, uas tshwm sim raws li:

• Pancreatitis, mob plab, cem quav, xeev siab, pom pob txha, daj ntseg, mob plab, ntuav, raws plab thiab mob siab,
• Paresthesia, peripheral neuropathy, qhov muag plooj, pom kev tsis meej, kiv taub hau, asthenia, mob taub hau, insomnia thiab ua txhaum ntawm saj hnov,
• Rhabdomyolysis, mob myopathy, mob leeg thiab myalgia,
• Cov tawv nqaij ua pob xua, alopecia, thiab mob pob khaus,
• Kev mob caj dab, mob ntsws zoo li mob ntsws, mob eosinophilia, ua rau lub cev tsis muaj zog, mob hlwb, dermatomyositis, kub taub hau, nce ESR, urticaria, polymyalgia rheumatism, vasculitis, thrombocytopenia, arthralgia, photosensitivity, flushing ntawm lub ntsej muag thiab txog siav,
• Mob raum tsis ua haujlwm, palpitations, anemia, thiab txo qis potency.

Vasilip - Kev txheeb xyuas txog Vasilip - Nqe ntawm Vasilip

Vasilip yog lwm qhov tshuaj los ntawm pab pawg ntawm statins, uas yog, cov tshuaj uas tuaj yeem txo cov roj hauv cov ntshav hauv tib neeg. Nws yog tsim ntawm lub hauv paus ntawm simvastatin - ib yam khoom uas tau txais los ntawm ntuj tsim cov khoom nyoos (nceb).

Raws li kev npaj zoo sib xws, ib tug yuav hais, piv txwv li, Atoris, uas yog ua raws li atorvastatin - ib qho tshuaj muaj hluavtaws. Cov nyhuv ntawm vasilip ua kom pom tseeb (thaum kuaj ntshav kuaj ntshav) ob lub lis piam tom qab pib kev kho mob. Qhov siab tshaj plaws ntawm cov tshuaj yog pom tom qab ib hlis - ib thiab ib nrab.

Yuav ua li cas kom ua tiav lub concentration ntawm cov roj (cholesterol) thiab lwm cov rog (triglycerides thiab lwm yam) txo qis yog qhov tsim nyog yuav tsum tau xyuas qee zaus los ntawm kev tso ntshav "rau biochemistry". Cov ntsiab lus rau kev teem caij Vasilip tuaj yeem muab ob qho tib si nrhiav thiab cov mob muaj keeb ntawm hypercholesterolemia.

Ib qho ntxiv, kev tiv thaiv thiab kev kho mob ntawm atherosclerosis, mob plawv, thiab lwm yam kev mob ntshav nrog los ntawm cov rog hauv cov ntshav siab tuaj yeem thiab yuav tsum tau txais kev txhawb nqa los ntawm kev siv cov tshuaj no.

Vasilip yog muaj nyob hauv daim ntawv foos. Lub tswv yim tseem ceeb heev rau kev maj mam xaiv cov koob tshuaj, uas tau piav qhia los ntawm kev qhia ntawm cov tshuaj. Pib nrog qhov kev xav tsawg kawg ntawm Vazilip, tus kws kho mob yuav tsum tau soj ntsuam cov neeg mob lub cev sai thiab hloov pauv lub sijhawm teem tseg (nce lub koob) tsis pub ntau tshaj ib hlis ib zaug.

Hauv tib lub sijhawm, tus neeg mob yuav tsum ua raws li cov zaub mov tshwj xeeb, txwv tsis pub txoj kev kho statin tsuas yog poob nws lub ntsiab lus.

Tus kws kho mob sau ntawv rau Vasilip kuj yuav tsum ua tib zoo ntsuas tus neeg mob lub siab thiab lub raum noj qab haus huv, nrhiav seb nws noj tshuaj dab tsi, nws txoj kev ua neej zoo li cas ... Hauv lwm cov lus, statins, txawm hais tias lawv tuaj yeem hloov pauv qhov xwm txheej nrog cov roj cholesterol, yuav tsum yog tus kws kho mob zoo. Lub luag haujlwm tshawb xyuas lawv cov nyhuv dhau sijhawm.

Vasilip yog contraindicated nyob rau hauv cov kab mob ntawm lub raum, mob siab, tus kheej intolerance, cev xeeb tub thiab lactation, menyuam yaus thiab tub ntxhais hluas. Yog tias ib tug poj niam siv cov tshuaj no, nws yuav tsum ua tib zoo tiv thaiv nws tus kheej los ntawm kev siv cev xeeb tub. Yog tias tus neeg mob npaj yuav xeeb tub, nws yuav tsum tsis txhob noj tshuaj Vasilip.

Phiv los sis vasilip

Nrog kev siv tshuaj kom raug, kev saib xyuas lub sijhawm ntshav thiab kev ua haujlwm ntawm lub cev lub cev tseem ceeb, kev ua kom pom qhov tsis xav tau piav qhia yog "tsis tshua muaj" (uas yog, ib kis rau ntau txog kaum txhiab tus mob Vasilip kho).

Kev zom, lub paj hlwb, leeg nqaij yuav cuam tshuam. Piv txwv, qhov mob ntawm daim siab ua rau mob taub hau, mob taub hau, mob nqaij leeg, mob plab thiab lwm yam.

Kev ua xua tuaj yeem ua txawv - los ntawm cov pob khaus me mus rau kev siv tshuaj txhaum cai ntau.

Cov ntsiav tshuaj Vasilip: taw qhia rau kev siv, tshuaj xyuas tus neeg mob

Vasilip yog yeeb tshuaj uas yog los ntawm pab pawg lipid-txo qis.Lub ntsiab lus tseem ceeb ntawm nws cov kev ua yog tias nws yog txhawm rau txo qis ntawm lipids (rog) hauv cov ntshav. Vasilip muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb hauv zaj duab xis membrane, puag ncig, me ntsis convex ntawm ob sab.

Cov khoom siv tseem ceeb ntawm tus neeg sawv cev no yog simvastatin. Nws kuj tseem muaj cov tshuaj ntxiv xws li lactose monohydrate, pregelatinized hmoov txhuv nplej siab, anhydrous citric acid, vitamin C, hmoov txhuv pob kws, magnesium stearate thiab microcrystalline cellulose. Lub plhaub tshuaj ntsiav nws tus kheej muaj talc, propylene glycol, hypromellose thiab titanium dioxide.

Qhov ntau npaum ntawm cov tshuaj yog ntawm ob hom - 20 thiab 40 mg txhua.

Tus txheej txheem ntawm kev txiav txim ntawm vasilip

Txij li Vasilip belongs rau lipid-txo tshuaj, nws cov tshuab ntawm kev coj ua yog qhov tsim nyog. Ua ntej tshaj plaws, vasilip txo qhov kev xav ntawm tag nrho cov roj hauv cov ntshav. Nws muaj ob hom roj (cholesterol) - “phem” thiab “zoo”. "Phem" yog lipoproteins uas tsis muaj ntau, thiab "zoo" yog lipoproteins ntau ntom.

Vasilip muaj cov txiaj ntsig rau theem pib ntawm kev tsim cov roj (cholesterol). Nws suav nrog kev hloov pauv ntawm HMG-CoA (hydroxymethylglutaryl coenzyme A) rau mevalonic acid. Qhov kev hloov pauv no tshwm sim nyob rau hauv kev tiv thaiv ntawm enzyme HMG-CoAreductase.

Vasilip muaj qhov cuam tshuam ntawm qhov enzyme no, vim tias cov roj (cholesterol) tsuas tsis ua. Cov tshuaj kuj cuam tshuam cov roj cholesterol, uas yog twb nyob hauv lub cev.

Nws txo cov roj cholesterol kom tsawg nrog cov lipoproteins uas tsis muaj ntau, thiab nws kuj txo qis ntawm triglycerides.

Nws yog cov tshuaj ntawm lipid xwm uas yog lub luag haujlwm rau kev tsim cov atherosclerotic plaques hauv lumen ntawm cov hlab ntsha. Tab sis cov tshuaj tsub kom ntau ntawm cov roj "zoo" cov roj - cuam tshuam nrog lub siab lipoproteins. Qib ntawm apolipoprotein B, lub tshwj xeeb thauj cov protein muaj lub luag haujlwm thauj cov roj hauv thoob plaws lub cev, kuj tseem raug txo qis.

Ntxiv nrog rau kev txo qis qib qee yam ntawm lipids, cov tshuaj tseem ceeb ntawm Vasilip cuam tshuam rau vascular phab ntsa thiab ntshav nws tus kheej.

Ntshav cov ntsiab lus xws li macrophages, uas ua lub luag haujlwm tseem ceeb hauv kev tsim cov roj cholesterol, yog tshuaj los ntawm cov tshuaj, thiab cov plaques lawv tus kheej raug rhuav tshem.

Tsis tas li, kev sib txuas ntawm cov tshuaj hu ua isoprenoids, uas yog lub luag haujlwm rau kev loj hlob ntawm cov hlwb hauv cov leeg nqaij ntawm cov hlab ntshav, yog qhov tsis tshua pom tshwm sim, vim tias lub nkoj phab ntsa tsis tuab, thiab lawv cov lumen tsis nqaim. Thiab ntxiv rau, Vasilip ceev cov hlab ntshav kom zoo thiab txhim kho cov ntshav kev khiav haujlwm.

Nta ntawm cov khw muag tshuaj ntawm vasilip

Vasilip yog noj. Nws yog qhov zoo heev nqus tau los ntawm phab ntsa ntawm txoj hnyuv.

Qhov siab tshaj plaws ntawm cov tshuaj yog pom ib mus rau ob teev tom qab nws tswj hwm, tab sis tom qab 12 teev nws txo mus txog 10%. Cov tshuaj tuaj yeem noj nrog zaub mov, qhov no yuav tsis cuam tshuam nws cov nyhuv.

Tsis tas li, nws tsis tuaj yeem ntau hauv lub cev nrog kev siv ntev. Cov tshuaj yog nruj heev khi rau cov ntshav protein, yuav luag 100%.

Vasilip tau hloov pauv mus ua ib qho kev sib xyaw ua ke hauv daim siab. Cov compound no yog hu ua beta hydroxy acid. Nws txoj kev tshem tawm (tshem tawm) yog nqa tawm los ntawm txoj hnyuv loj. Cov tshuaj tawm hauv daim ntawv ntawm metabolites (hloov khoom tsim khoom).

Ib feem me me ntawm nws tau tawm los ntawm lub raum, tab sis ib daim ntawv tsis muaj zog ntawm cov compound tawm dhau los ntawm ob lub raum.

Kev taw qhia thiab contraindications rau siv

Cov kws kho mob feem ntau sau ntawv rau vasilip rau ib qho mob xws li atherosclerosis. Nws kuj tseem muaj ntau rau thawj hypercholesterolemia los yog sib xyaw dyspidemia (ua txhaum ntawm qhov sib piv ntawm cov ntshav lipids) sib xyaw nrog cov kev ua haujlwm hauv lub cev, kev poob phaus, ua raws li kev noj zaub mov, lossis tsis muaj txiaj ntsig ntawm lwm yam tshuaj.

Lwm qhov taw qhia yog homozygous cov kab mob hypercholesterolemia. Lawm, nyob rau hauv parallel, zaub mov noj thiab kev nqus ntawm lwm cov tshuaj tiv thaiv atherosclerotic yuav tsum ua raws.

Vasilip kuj tseem raug kho rau kev tiv thaiv kab mob ntawm cov hlab plawv nrog cov mob atherosclerosis lossis ntshav qab zib, vim tias nws muaj kev pheej hmoo siab los ntawm kev mob plawv, mob hlwb thiab ntau yam vascular pathologies.

Thiab tom kawg ib qho tsuas yog ua rau kom cov roj (cholesterol) ntau tuaj thaum tsis muaj kev kuaj mob.

Vasilip yog contraindicated rau hauv cov xwm txheej xws li:

• mob siab tus mob nyob rau theem mob lossis daim ntawv nquag,
• lub sij hawm ntev nce nyob rau hauv daim siab enzymes tsis muaj tus tsim,
• cev xeeb tub thiab lactation,
• muaj hnub nyoog me
• kev tsis haum tshuaj rau simvastatin lossis lwm yam tshuaj ntawm cov tshuaj.

Kev saib xyuas tshwj xeeb yuav tsum them rau cov neeg mob uas muaj cov kabmob li hauv qab no lossis qee qhov kev mob tshwj xeeb:

1. Nrog haus cawv ntau dhau.
2. Nyob rau hauv muaj cov kab mob cuam tshuam rau daim siab.
3. Lub xub ntiag ntawm electrolyte tsis txaus ntseeg nyob rau hauv lub cev.
4. Kev ua txhaum loj ntawm cov endocrine system thiab cov metabolism.
5. Tsis tu ncua txo lub siab (hypotension).
6. Cov hlwv tso quav ntawm lub cev.
7. Kab mob ntawm cov leeg mob.
8. Kho tsis tau mob qaug dab peg.
9. Kev phais mob lossis raug mob hnyav.
10. Tsis muaj lactase, ib qho enzyme uas zom lactose (mis qab zib).
11. Kev ua txhaum ntawm cov txheej txheem ntawm kev nqus ntawm lactose.

Cov lus qhia rau kev siv tshuaj

Ua ntej yuav siv cov tshuaj twg, koj yuav tsum sab laj nrog koj tus kws kho mob txog kev haus dej haus cawv rau koj kom zoo thiab kom paub txog cov lus siv. Kev tswj hwm tus txheej txheem yog yuav tsum noj ib lossis ntau dua ib ntsiav tshuaj ib hnub ib zaug thaum yuav mus pw.

Nws raug nquahu kom noj cov tshuaj thaum hmo ntuj, vim tias thaum hmo ntuj, cov tshuaj tua cov roj (cholesterol) ntau tshaj plaws, tau ua tiav, thiab cov nyhuv tshuaj ua rau lub zog tawm ntau. Feem ntau pib nrog koob tshuaj 10 mg. Qhov siab tshaj plaws pub siv tau yog 80 mg rau ib hnub.

Nws yog tshuaj rau cov neeg mob uas muaj cov kab mob qib siab, nrog rau kev pheej hmoo siab ntawm cov kev mob tshwm sim los ntawm lub siab thiab cov hlab ntshav. Qhov yuav tsum tau txhaj nyob hauv feem ntau yuav tau xaiv hauv ib hlis.

Lub sijhawm ua haujlwm ntawm txoj kev kho yog xaiv cais rau txhua tus neeg mob los ntawm nws tus kws kho mob.

Nws yuav tsum nco ntsoov tias thaum noj Wazilip, tus neeg mob ib leeg nws muaj zaub mov noj uas nws yuav tsum ua raws. Qee qhov, lwm cov tshuaj lipid-txo qis kuj tseem raug kho.

Rau cov neeg mob uas muaj kab mob xws li hypercholesterolemia, kev kho mob pib nrog lub koob tshuaj 10 mg, tab sis nws tuaj yeem nce ntxiv txog 40 mg kom tau txais cov txiaj ntsig tshaj tawm.

Rau cov kab mob muaj keeb ntawm tus kab mob no, Vazilip tau muab faib ua peb zaug yog tias qhov ntau tshaj qhov tau muab tshuaj (80 mg), lossis 40 mg ntawm cov tshuaj tau tawm ib hnub ib zaug ua ntej yuav mus pw.

Vasilip muaj cov txiaj ntsig xav tau ob qho tib si hauv kev siv ib qho thiab hauv kev sib xyaw nrog lwm tus neeg cov tshuaj tiv thaiv kab mob, tshwj xeeb, nrog cov kua tsib acid sequestrants. Cov no yog cov tshuaj xws li colestyramine, colestipol.

Nrog kev siv cov tshuaj cyclosporine, gemfibrozil, nicotinic acid los yog tshuaj los ntawm cov pab pawg ntawm cov fibrates, lawv pib nrog koob tshuaj 5 mg, thiab qhov siab tshaj plaws tau tso cai yog 10 mg.

Hauv qhov no, koj yuav tsum tsis pub tshaj qhov koob tshuaj no.

Yog tias tus neeg mob noj tshuaj tiv thaiv arrhythmia thiab ntshav siab, xws li Amiodarone thiab Verapamil, ces cov koob tshuaj Vasilip yuav tsum tsis pub ntau tshaj 20 mg rau ib hnub, vim lawv kev sib raug zoo tsis tiav.

Yog tias ib tug neeg raug mob hnyav dhau los ua rau lub raum tsis ua haujlwm, nyob rau hauv uas txhaws qhov quav tsis tshaj 30 ml / min., Tom qab ntawd Vasilip raug kho nyob rau hauv ib koob tshuaj tsis ntau tshaj 10 mg ib hnub twg. Cov koob tshuaj yuav tsum tau nce siab kom zoo, thiab hauv qhov no tus neeg mob yuav tsum tau soj ntsuam tas li.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Vasilip yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb (7 pcs. Hauv ib lub blister), uas yog coated nrog ib zaj duab xis membrane.

Cov lus qhia rau kev siv Vasilip (qauv thiab ntau npaum li cas)

Cov ntsiav tshuaj yog npaj rau cov thawj coj ntawm qhov ncauj, ib zaug thaum yav tsaus ntuj.

Cov koob tshuaj pom zoo nws txawv ntawm 5 mg txog 80 mg ib hnub ib zaug thaum yav tsaus ntuj. Thawj qhov tshuaj ntawm cov tshuaj yog 10 mg. Kev pauv siv koob tshuaj yuav tsum tau ua ntawm intermittently tsawg kawg 4 lub lis piam.

Qhov siab tshaj plaws tau tso cai rau noj txhua hnub txog 80 mg. Nws yog kho tsuas yog rau cov neeg mob uas muaj kev pheej hmoo siab mob plawv los yog mob ntshav siab ntau dua.

Lub sijhawm noj cov ntsiav tshuaj yog txiav txim los ntawm tus kws khomob mus koom ib tus zuj zus.

Hypercholesterolemia

Nyob rau tag nrho lub sijhawm ntawm kev kho, tus neeg mob yuav tsum tau ua raws cov qauv kev noj zaub mov hypocholesterol. Qhov pom zoo kom pib koob tshuaj rau cov neeg mob hypercholesterolemia yog 10 mg. Txhawm rau kom muaj ntau dua qhov txo qis hauv LDL-C, txoj kev kho tuaj yeem pib los ntawm 20 txog 40 mg rau ib hnub (ib zaug thaum yav tsaus ntuj).

Hauv cov neeg mob uas muaj homozygous kab mob siab hypercholesterolemia, koob tshuaj txhua hnub yog 40 mg rau yav tsaus ntuj lossis 80 mg hauv 3 faib koob tshuaj (20 mg thaum sawv ntxov, 20 mg thaum yav tav su thiab 40 mg thaum yav tsaus ntuj).

Kev Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob

Hauv cov neeg mob uas muaj lossis tsis muaj hyperlipidemia, uas muaj kev pheej hmoo siab mob ntsig txog mob plawv, cov tshuaj tiv thaiv zoo yog 20 mus rau 40 mg ib hnub. Yog li, cov tshuaj pom zoo kom pib mus txog 20 mg rau ib hnub.

Kev pauv koob tshuaj yuav tsum tau ua ntawm kev ncua sijhawm ntawm 4 lub lis piam. Yog tias tsim nyog, cov koob tshuaj yuav raug nce ntxiv rau 40 mg ib hnub twg.

Yog tias cov ntsiab lus LDL tsawg dua 75 mg / dl (1.94 mmol / L), cov roj (cholesterol) tag nrho cov ntsiab lus tsawg dua 140 mg / dl (3.6 mmol / L), qhov koob tshuaj yuav tsum raug txo kom tsawg.

Ntsuas kev kho mob

Vasilip muaj txiaj ntsig zoo ua ke nrog cov kua tsib acid sequestrants lossis hauv kev kho mob monotherapy. Hauv cov neeg mob tau txais kev kho mob nrog gemfibrozil, cyclosporine, nicotinic acid los yog lwm cov fibrates (ntau dua 1 g hauv ib hnub), qhov kev pib siv yog 5 mg. Qhov siab tshaj plaws tau tso cai noj tshuaj txhua hnub yog 10 mg. Ntxiv qhov koob tshuaj tsis pom zoo.

Hauv cov neeg mob ib txhij noj verapamil lossis amiodarone, cov tshuaj txhua hnub ntawm cov tshuaj yuav tsum tsis pub ntau dua 20 mg.

Cov Tshuaj Hauv Tshuaj

Simvastatin - cov tshuaj nquag ntawm Vasilip, yog ib qho lipid-txo tus neeg sawv cev tau synthetically los ntawm cov khoom fermentation Aspergillus terreus.

Tom qab kev tswj hwm ntawm qhov ncauj, simvastatin, uas yog ib qho kev tawm dag zog tsis muaj zog, ua haujlwm rau lub cev hydrolysis nyob rau hauv daim siab, nrog kev tsim cov tshuaj sib xws ntawm the-hydroxy acid ntawm cov tshuaj yeeb dej caw. Nws yog cov metabolite tseem ceeb thiab muaj qhov kev tiv thaiv zoo tiv thaiv HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) -reductase, ib qho enzyme uas catalyzes cov tshuaj lom roj ntsha (pib thiab tseem ceeb tshaj plaws theem) ntawm cov roj (cholesterol).

Qhov ua tau zoo ntawm simvastatin hauv kev txo plasma cov ntsiab lus ntawm cov roj cholesterol tag nrho, cov roj cholesterol tag nrho, LDL cov cholesterol, cov roj lipoprotein tsawg, cov roj triglycerides thiab cov roj lipoprotein tsawg heev, thiab cov roj cholesterol HDL nce siab (cov roj lipoprotein ntau) ntom) hauv cov ntshav ntshav hauv cov neeg mob heterozygous tsev neeg / tsis-tsev neeg hypercholesterolemia los yog sib xyaw hyperlipidemia nyob rau hauv cov mob thaum cov ntshav nce ntxiv hauv lub siab ntawm cov roj cholesterol hauv cov ntshav yog ntawm cov s kev pheej hmoo thiab kev teem caij ntawm ib qho khoom noj tsis txaus. Cov txiaj ntsig kho tau tshwm sim tau pom nyob hauv 14 hnub tom qab noj cov tshuaj simvastatin, qhov siab tshaj plaws nyob rau hauv 4-6 lis piam txij li hnub pib siv. Nrog kev kho txuas ntxiv, cov nyhuv tseem mob. Lub plasma concentration ntawm cov roj (cholesterol) tom qab tsum tsis txhob siv cov simvastatin hauv cov ntshav rov qab rau nws tus nqi qub, uas tau pom ua ntej pib kev kho mob.

Cov nquag metabolite ntawm simvastatin yog ib hom tshwj xeeb ntawm HMG-CoA reductase (ib qho enzyme uas catalyzes cov tshuaj tiv thaiv ntawm kev tsim mevalonate los ntawm HMG-CoA). Txawm li cas los xij, kev tswj hwm kev kho tshuaj ntawm cov tshuaj tsis ua rau kev ua tiav ntawm kev txwv tsis pub HMG-CoA reductase, yog li tswj hwm kev tsim cov roj ntsha tsim nyog ntawm mevalonate. Nws ntseeg tau tias kev siv vasilip yuav tsum tsis txhob ua rau kev sib txuam ntawm cov tshuaj lom neeg lub cev hauv lub cev, txij li theem pib ntawm kev siv roj ntsha ua ke ntawm cov roj yog cov hloov dua siab tshiab ntawm HMG-CoA rau mevalonate. Tsis tas li ntawd, muaj cov metabolism nrawm nrawm ntawm HMG-CoA rau acetyl-CoA, uas koom tes nrog ntau cov txheej txheem biosynthesis hauv lub cev.

Cov roj (cholesterol) yog qhov ua ntej ntawm txhua tus tshuaj steroid, thiab kev soj ntsuam zoo ntawm simvastatin ntawm steroidogenesis tsis pom. Txij li Vasilip tsis ua rau muaj qhov nce ntawm lithogenicity ntawm bile, nws cov nyhuv ntawm qhov nce ntawm qhov tshwm sim ntawm cholelithiasis tsis zoo li.

Simvastatin pab txo qis kom muaj zog thiab muaj zog ntau ntawm LDL cov cholesterol nyob hauv cov ntshav ntshav. Kev tsim ntawm LDL yog los ntawm VLDL (lipoproteins tsawg ntom ntom ntom). LDL catabolism tau ris nrog kev pab los ntawm kev sib raug zoo siab LDL receptor. Qhov kev ua kom txo qis kev sib xyaw ntawm LDL cov roj cholesterol hauv ntshav plasma tom qab noj simvastatin yuav yog vim ob qho kev txo qis hauv plasma concentration ntawm VLDL cov roj (cholesterol) hauv cov ntshav thiab ua kom LDL receptors. Vim tias qhov no, muaj kev txo qis hauv kev tsim thiab nce catabolism ntawm LDL cov roj (cholesterol). Thaum kho nrog simvastatin, qhov ntshav plasma concentration ntawm apolipoprotein B (apo B) hauv cov ntshav kuj txo qis qis. Txij li thaum txhua qhov LDL particle muaj ib qho apo B molecule, thiab ib qho me me ntawm apo B pom nyob hauv lwm cov lipoproteins, nws tuaj yeem xav tias simvastatin, ntxiv rau qhov ua rau cov roj cholesterol nyob hauv LDL hais, pab txo cov ntshav plasma ntawm cov ntshav LDL cov roj ntsha hauv cov ntshav.

Simvastatin tseem tsub kom lub siab ntawm HDL cov roj cholesterol thiab txo cov tshuaj TG hauv cov ntshav ntshav. Raws li qhov kev sib raug zoo no, LDL-C / HDL-C thiab HDL / HDL-C raug txo qis.

Nrog rau cov kab mob ntshav siab (mob plawv) thiab qhov pib ntawm cov roj (cholesterol) tag nrho ntawm 212–309 mg / dL (5.5 txog 8 mmol / l), simvastatin pab txo txoj kev pheej hmoo ntawm kev tuag tag nrho, kev tuag los ntawm kab mob plawv, thiab qhov tshwm sim ntawm tsis yog tshuaj tua kab mob myocardial infarction. Tsis tas li ntawd, cov tshuaj muaj zog txo qhov ua rau muaj qhov yuav tsum tau ntawm kev phais mob kom rov qab muaj ntshav txaus rau ntshav (piv txwv li, mob hlab ntsha o hla kev sib tsoo lossis percutaneous transluminal coronary angioplasty). Tawm tsam keeb kwm ntawm cov ntshav qab zib mellitus, qhov tshwm sim ntawm qhov tshwm sim ntawm cov kab mob tseem ceeb txo qis. Ntxiv mus, thaum simvastatin txoj kev kho, qhov kev pheej hmoo ntawm kev tsim kev tuag ntawm cov kab mob tuag tes tuag taw / tsis muaj neeg tuag taus (suav nrog rau cov mob hlab ntaws thiab cov kab mob hloov pauv tsis tu ncua) txo qis.

Muaj pov thawj ntawm kev ua tau zoo ntawm simvastatin hauv cov neeg mob nrog / tsis muaj hyperlipidemia, uas muaj kev pheej hmoo loj ntawm kev mob plawv coronary vim concomitant ntshav qab zib mellitus, keeb kwm ntawm mob hlab ntsha tawg thiab lwm yam kab mob vascular.

Nrog rau kev siv Vasilip hauv ib hnub ntawm 40 mg, tag nrho kev tuag, kev pheej hmoo ntawm kev tuag cuam tshuam nrog cov kab mob plawv, txoj kev pheej hmoo ntawm cov kab mob ntshav siab tseem ceeb (suav nrog kev tsis mob ntshav qab zib lossis tuag ua mob rau cov kab mob plawv), xav tau kev phais mob los kho lub plawv ntshav txaus. (suav nrog kev mob rau txoj hlab ntshav ntawm kev hla pob txha thiab txhawm rau txhawm rau txhawm rau lub zog angioplasty), nrog rau cov ntshav ntws tawm thiab lwm yam kev mob tsis muaj kabmob, muaj kev pheej hmoo ntawm mob hlab ntsha tawg, qhov ntau zaus ntawm tsev kho mob rau se lub plawv tsis ua hauj lwm.

Qhov ntxim nyiam ntawm cov vascular / mob caj dab tseem ceeb txo qis hauv cov neeg mob uas / tsis muaj mob rau cov hlab ntsha, nrog rau cov neeg mob peripheral vascular, ntshav qab zib mellitus, lossis cerebrovascular pathologies. Hauv cov ntshav qab zib mellitus, Vasilip pab txo txoj kev pheej hmoo ntawm kev mob ntshav khov, suav nrog kev xav tau kev phais mob rau txiav tawm ntawm qhov qis qis, kho kom rov qab los ntawm cov ntshav tawm, thiab qhov tshwm sim ntawm qhov mob trophic.

Raws li kev mob hlwb ntawm lub plawv, txoj kev simvastatin kho qis qeeb ntawm kev mob ntshav siab thiab mob tawm ntawm ob qho chaw tshiab ntawm atherosclerosis thiab cov kab mob tshiab tag nrho, thaum cov neeg mob tau txais cov kev kho mob tau pom tias muaj kev hloov pauv ntawm atherosclerotic txhab ntawm cov hlab ntshav ntawm cov hlab ntsha.

Cov Tshuaj Pharmacokinetics

Simvastatin yog ib qho tshuaj lactone tsis muaj zog. Cov tshuaj hloov sai sai, nrog nws hloov mus rau simvastatin hydro-hydroxy acid (L-654.969), uas yog lub zog txwv ntawm HMG-CoA reductase. Cov khoom tseem ceeb ntawm simvastatin hauv cov ntshav plasma yog β-hydroxyacid ntawm simvastatin (L-654.969) thiab nws cov 6'-exomethylene, 6'-hydroxy thiab 6'-hydroxymethyl derivatives.

Cov qauv rau kev ntsuas ntau npaum li cas ntawm txhua qhov kev tshawb fawb pharmacokinetic ntawm ites-hydroxy acid metabolites (cov tshuaj tiv thaiv kev cuam tshuam) thiab ua kom nquag plias / cov latent inhibitors (txhua yam tshuaj tiv thaiv) uas tsim los ntawm hydrolysis yog qhov kev txwv ntawm HMG-CoA reductase. Thaum noj cov simvastatin hauv cov ntshav ntshav, ob hom metabolites tau txiav txim siab.

Hydrolysis ntawm simvastatin tshwm sim ntau dua thaum lub sijhawm pib los ntawm daim siab, yog li ntawd, qhov ntshav qis tsawg kawg ntawm simvastatin tsis raug hloov hauv tib neeg cov ntshav tau pom (14 C sau cim simvastatin + 14 C sau cim simvastatin metabolites) tau tiav hauv 4 teev. Tom qab 12 teev ntawd nws nrawm poob mus txog 10% ntawm tus nqi siab. Dua li ntawm qhov tseeb hais tias qhov ntau ntawm kev pom zoo kev kho mob ntawm simvastatin yog los ntawm 5 txog 80 mg rau ib hnub, qhov xwm yeem ntawm AUC profile (thaj chaw hauv qab qhov kev cia siab-nkhaus) ntawm cov metabolites nyob rau hauv tag nrho cov ntshav txaus nrog nce ntxiv rau 120 mg yog pom.

Kwv yees li 85% ntawm kev lees txais ntawm simvastatin yog nqus tau. Noj (raws li ib feem ntawm kev noj tshuaj hypocholesterol) tam sim ntawd tom qab noj simvastatin tsis cuam tshuam rau qhov profile pharmacokinetic ntawm cov tshuaj.

Kev siab dua ntawm simvastatin yog txiav txim siab hauv lub siab (piv rau lwm cov ntaub so ntswg).

Qhov kev txiav txim siab hauv cov kab ke ntsig mus ntawm cov nquag metabolite ntawm simvastatin L-654.969 yog 60% hauv txiv neej).

Txoj kev muaj peev xwm nkag mus ntawm cov khoom los ntawm cov ntshav-lub hlwb thiab hematoplacental teeb meem tsis tau kawm.

Simvastatin thaum lub sijhawm pib nkag mus rau daim siab yog metabolized, tom qab kev tawm ntawm cov tshuaj thiab nws cov metabolites tshwm sim nrog bile.

Thaum noj 100 mg ntawm simvastatin 14 C, cov tshuaj cim tso rau hauv cov ntshav ntshav, nrog rau cov quav (li 60%) thiab tso zis (li 13%). Hauv cov quav, daim ntawv lo simvastatin yog sawv cev los ntawm cov khoom lag luam metabolic ntawm simvastatin, uas tawm hauv cov kua tsib, thiab tsis muaj ntawv cim npe simvastatin. Tsawg dua 0.5% ntawm qhov tau lees txais ntawm cov ntawv sau tshuaj uas pom muaj nyob hauv cov zis nyob rau hauv daim ntawv ntawm kev siv tshuaj tiv thaiv lub cev. Hauv plasma, 14% thiab 28% ntawm AUC yog vim muaj cov yam tshuaj tiv thaiv kab mob thiab txhua tus mob ntawm HMG-CoA reductase, feem. Qhov no qhia tau tias feem ntau cov khoom lag luam metabolic ntawm simvastatin yog cov tshuaj tiv thaiv tsis muaj zog lossis tsis muaj zog ntawm HMG-CoA reductase.

Kev pom qhov txawv txav ntawm kab ncaj ncaj ntawm AUC hauv tag nrho cov ntshav ntws nrog nce ntxiv hauv thaj tsam ntawm 5-120 mg tsis pom. Nrog ib qho kev rov qab haus thiab haus ib zaug ntawm simvastatin, cov khoom siv tshuaj pharmacokinetic qhia tau tias tsis muaj cov tshuaj ntau ntxiv nyob rau hauv cov ntaub so ntswg thaum siv tas.

Hauv kev mob raum tsis ua haujlwm (hauv cov neeg mob uas muaj creatinine tshem ntawm 10 mg ib hnub twg, yog tias tsim nyog, kev kho mob tau sau nrog ceev faj,

Vasilip, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Cov ntsiav tshuaj Vasilip yog noj ntawm qhov ncauj, 1 zaug hauv ib hnub, thaum yav tsaus ntuj. Qhov pom zoo kom noj tshuaj txhua hnub txawv txav ntawm 5 mg txog 80 mg.

Feem ntau, qhov tshuaj tau sau tseg rau hauv thawj zaug pib noj 10 mg. Cov koob tshuaj pauv yuav tsum tau ua nrog ib lub sijhawm tsawg kawg 4 lub lis piam. Qhov siab tshaj plaws niaj hnub noj tshuaj (80 mg) pom zoo tsuas yog rau cov neeg mob hypercholesterolemia loj heev los yog muaj kev pheej hmoo siab ntawm kev txhim kho hlab plawv. Lub sijhawm ntawm vasilip yog txiav txim siab ib tus zuj zus los ntawm tus kws kho mob koom nrog.

Thoob plaws sijhawm tag nrho ntawm kev kho, tus neeg mob yuav tsum tau ua raws cov qauv kev noj zaub mov hypocholesterol. Qhov pom zoo kom pib noj yog 10 mg. Txhawm rau kom pom tseeb ntau dua qhov kev txo qis ntawm LDL-C (los ntawm ntau dua 45%), koj tuaj yeem pib noj Vasilip nrog 20-40 mg ib hnub ib zaug, yav tsaus ntuj.

Cov neeg mob nrog homozygous kab mob siab hypercholesterolemia raug pom zoo kom noj 40 mg ib hnub ib zaug, thaum yav tsaus ntuj. Nws yog tau los siv nyob rau hauv 3 koob - thaum sawv ntxov thiab yav tav su, 20 mg thiab 40 mg thaum yav tsaus ntuj. Vasilip pom zoo rau cov neeg mob ua ke nrog lwm txoj kev kho lipid-piv txwv (piv txwv li, LDL apheresis).

Hauv kev tiv thaiv cov kab mob plawv:

Nrog txoj kev pheej hmoo siab ntawm kev txhim kho cov hlab plawv (nrog lossis tsis muaj hyperlipidemia), 20-40 mg ntawm Vasilip tau sau tseg rau ib hnub. Thawj koob tshuaj yog 20 mg, qhov nce ntxiv ntawm koob tshuaj yuav tsum tshwm sim nrog lub sijhawm luv ntawm tsawg kawg 4 lub lis piam. Qhov nyiaj pab ntau tshaj txhua hnub yog 40 mg. Thaum cov ntsiab lus LDL tsawg dua 75 mg / dl (1.94 mmol / L), cov roj (cholesterol) tag nrho cov ntsiab lus tsawg dua 140 mg / dl (3.6 mmol / L), qhov tshuaj yuav tsum tau txo.

Vasilip muaj txiaj ntsig zoo ntawm kev kho mob lossis ib txhij nrog cov tshuaj tiv thaiv cov kua tsib (piv txwv li, colestipol thiab colestyramine). Hauv cov neeg mob tau txais kev kho mob nrog gemfibrozil, cyclosporine, lwm yam fibrates lossis nicotinic acid (ntau dua 1 g ib hnub), nws raug nquahu kom pib kho nrog 5 mg rau ib hnub, qhov siab tshaj plaws txhua hnub koob tshuaj yog 10 mg. Hauv cov xwm txheej zoo li no, tsis pom zoo ntxiv qhov koob tshuaj ntxiv.

Hauv cov neeg mob uas tau txais ob qho verapamil lossis amiodarone, koob tshuaj vasilip txhua hnub yuav tsum tsis pub tshaj 20 mg.

Hauv cov neeg mob uas mob raum tsis zoo (CC tsawg dua 30 ml / min), qhov pom zoo txhua hnub ntawm Vasilip yuav tsum tsis pub tshaj 10 mg. Yog tias koj xav nce cov tshuaj ntau ntxiv, yuav tsum muaj kev saib xyuas mob nkeeg.

Cov neeg mob uas lub raum tsis ua haujlwm thiab cov neeg laus tsis xav tau kev hloov kho koob.

Cev xeeb tub thiab lactation

Vasilip thaum cev xeeb tub / lactation tsis tau sau tseg.

Thaum cev xeeb tub tshwm sim, kev siv cov simvastatin yuav tsum nres tam sim ntawd. Cov poj niam ntawm lub hnub nyoog yug menyuam, Vasilip tuaj yeem raug kho tsuas yog tus neeg mob muaj feem me me. Kev siv tshuaj kho thaum cev xeeb tub tuaj yeem ua rau txo qis hauv qhov kev txiav txim siab ntawm mevalonate (lub sijhawm sib xyaw ua ntej ntawm cov roj cholesterol biosynthesis) hauv tus menyuam. Atherosclerosis yog suav hais tias yog ib tus mob ntev, thiab feem ntau tshem tawm cov lipid-txo cov tshuaj thaum cev xeeb tub tsis cuam tshuam loj rau lub sij hawm ntev uas cuam tshuam nrog thawj hypercholesterolemia. Hauv qhov no, simvastatin yuav tsum tsis txhob raug rau cov poj niam cev xeeb tub, xav ua cev xeeb tub lossis xav tias tsam lawv cev xeeb tub. Kev siv tshuaj Vasilip yuav tsum raug ncua rau lub sijhawm uas cev xeeb tub lossis txog thaum kuaj mob, thiab tus pojniam tus kheej yuav tsum tau ceebtoom rau qhov muaj kev phom sij rau tus menyuam hauv lub cev.

Tsis muaj pov thawj pom zoo lossis tsis zoo rau kev nthuav tawm ntawm simvastatin thiab nws cov khoom noj khoom haus nrog rau niam mis.

Cov nqi rau vasilip hauv cov khw muag tshuaj hauv Moscow

Contraindicated kev sib txuas:

• muaj zog inhibitors ntawm CYP3A4 isoenzyme (itraconazole, telithromycin, ketoconazole, posaconazole, clarithromycin, voriconazole, erythromycin, HIV protease inhibitors, boceprevir, nefazodone, telaprevir uas muaj cov tshuaj cobicistat): nws cuam tshuam nrog kuv nce ntxiv
• gemfibrozil, danazol lossis cyclosporine.

Cov kws kho mob tshuaj xyuas txog vasilip

Muaj ib lub sijhawm thaum ntau tus kws kho mob (tsis yog tshuaj!) Suav hais tias 10 mg ntawm vasilip yog ib txoj kev kho mob zoo rau cov kabmob uas muaj tus mob atherosclerosis. Zaum no ntev lawm. Simvastatin hauv ib daim ntawv tsis tau pom tias yog tshuaj uas tso cai rau koj kom ua tiav cov niaj hnub tsim nyog ntawm cov roj cholesterol thiab lwm cov lipids.

Yog li, yog tias tus kws kho mob tam sim no tau sau ntawv simvastatin (suav nrog vasilip), Kuv tus kheej tsis nkag siab vim li cas nws tsis quav ntsej txog cov kev cai tshiab niaj hnub no uas muaj cov nyhuv zoo dua thiab muaj kev nyab xeeb dua.

Nws yog lub sijhawm tsis nco qab txog simvastatin. Thiab los ntawm txoj kev, dab tsi yog qhov kev nkag siab yuam kev hais tias statins yuav tsum tsis txhob noj rau ntau tshaj li ob peb lub lis piam? Lawv raug coj mus rau xyoo thiab ntau xyoo, thiab txhua xyoo ntxiv ntawm kev txais neeg kawm coj tau cov txiaj ntsig ntxiv rau cov neeg mob, thiab cov tuam txhab tshuaj, tau kawg, ib yam nkaus.

Vasilip tus neeg mob tshuaj xyuas

Kuv noj "Vasilip" 10 mg tsis tu ncua rau 1 ntsiav tshuaj thaum yav tsaus ntuj, Kuv kuaj cov roj (cholesterol) ib zaug txhua peb lub hlis. Cov tshwm sim zoo heev. Muaj qhov tsis ua tiav qhov kev hloov pauv hloov mus rau qhov pheej yig hauv tsev ua haujlwm hauv tsev. Cov roj khov tawm hauv lub siab, rov mus rau "Vasilip". Nrog cov nyiaj laus, yuav khoom kim, tab sis kev noj qab haus huv nws kim dua.

"Vasilip" tau qhia rau kuv los ntawm kuv tus kws qhia noj zaub mov rau qhov poob phaus, tom qab sab laj nrog kws kho mob, Kuv tau coj los ua ke nrog zaub mov noj. Kuj ceeb tias, qhov tshwm sim tau zoo, txawm hais tias kuv tsis tau paub meej tias cov tabs yuav pab! Tau 5-6 lub lis piam, tsis muaj ntxiv! Tshuaj txo qis cov roj hauv cov ntshav, uas yog vim li cas qhov tshwm sim no!

Kws Tshuaj

Simvastatin tseem txo cov ntsiab lus ntawm apolipoprotein B, muaj pes tsawg nce ntawm kev sib xyaw ntawm HDL-C thiab txo qis ntshav ntau ntawm TG. Raws li cov txiaj ntsig ntawm simvastatin, qhov sib piv ntawm tag nrho Chs mus rau tag nrho Chs-HDL thiab Chs-LDL rau Chs-HDL txo.

Qhov ua tau antiatherosclerotic ntawm simvastatin yog qhov tshwm sim ntawm cov nyhuv ntawm cov tshuaj rau ntawm phab ntsa ntawm cov hlab ntsha thiab cov ntshav sib xyaw. Simvastatin hloov cov metabolism ntawm macrophages, inhibiting kev ua ntawm macrophages thiab kev puas tsuaj ntawm atherosclerotic plaques. Cov tshuaj inhibits lub synthesis ntawm isoprenoids, uas yog yam kev loj hlob hauv kev nthuav dav ntawm cov leeg hlwb ntawm cov leeg hauv cov hlab ntsha. Nyob hauv kev cuam tshuam ntawm simvastatin, endothelium-vam khom nthuav ntawm cov hlab ntshav txhim kho.

Kev kho mob tshwm sim tom qab 2 lub lis piam, cov nyhuv siab tshaj plaws tau pom tom qab 4-6 lub lim tiam ntawm kev kho mob.

Kev sib txuam

Kev siv simvastatin nrog fibrates, nicotinic acid (ntau dua 1 g / hnub) nce qhov kev pheej hmoo ntawm kev txhim kho myopathy, suav nrog rhabdomyolysis (nrog rau kev siv tib lub sijhawm nrog fenofibrate, tsis muaj kev pheej hmoo ntawm kev txhim kho myopathy piv rau kev kho mob monotherapy nrog txhua yam tshuaj cais).

Kev siv cov ntsiab lus nrog gemfibrozil tuaj yeem ua rau muaj qhov nce ntxiv ntawm cov simvastatin hauv cov ntshav dej.

CYP3A4 cytochrome inhibitors (itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors thiab nefazodone), uas koom nrog cov kev hloov pauv ntawm cov roj simvastatin ua rau lub siab, ua rau muaj kev pheej hmoo ntawm myopathy thiab rhabdomyolysis thaum kho mob nrog simvastatin. Kev siv yooj yim nrog cov tshuaj no yog contraindicated.

Nrog kev ceev faj, nws yog qhov yuav tsum tau muab tshuaj kom txhij nrog cov tsis muaj zog CYP3A4 inhibitors: cyclosporine, verapamil thiab diltiazem. Cov tshuaj txhua hnub ntawm simvastatin thaum noj nws nrog cyclosporine yuav tsum tsis pub tshaj 10 mg. Kev noj tshuaj txhua hnub ntawm simvastatin nrog kev siv tshuaj amiodarone los yog verapamil yuav tsum tsis pub tshaj 20 mg, thiab 40 mg nrog kev siv cov tshuaj diltiazem, tshwj tsis yog lub txiaj ntsig xav tau kom meej meej dhau txoj kev pheej hmoo ntawm myopathy thiab rhabdomyolysis.

Simvastatin ntawm kev noj tshuaj li 20-40 mg / hnub hauv cov neeg ua haujlwm pub dawb thiab cov neeg mob hypercholesterolemia potentiates qhov cuam tshuam ntawm coumarin anticoagulants (piv txwv li warfarin), tshwj xeeb kev nce prothrombin lub sijhawm, MHO. Yog li, hauv cov neeg mob noj cov tshuaj coumarin anticoagulants, lub sijhawm prothrombin thiab MHO yuav tsum txiav txim siab ua ntej pib simvastatin kev kho mob, hauv thawj lub sijhawm kho, thaum hloov cov tshuaj simvastatin lossis tsum tsis siv tshuaj. Thaum ncav lub cim ntsuas ruaj ntseg ntawm lub sijhawm prothrombin thiab MHO, kev tshuaj xyuas ntxiv yuav tsum tau ua nyob rau ntawm cov kev ncua sijhawm pom zoo rau cov neeg mob tau txais kev kho mob anticoagulant. Simvastatin kev kho mob tsis ua rau muaj kev hloov pauv prothrombin lub sijhawm thiab los ntshav ntau txaus hauv cov neeg mob tsis noj tshuaj anticoagulants.

Cov txiv kab ntxwv kua txiv inhibits qhov kev ua si ntawm CYP3A4. Kev pub ib txhij ntawm cov kua txiv kab ntxwv qaub ntau dua (ntau dua li 1 liter ib hnub) thiab simvastatin ua rau muaj qhov nce ntxiv ntawm qhov ntshav plasma concentration ntawm simvastatin acid. Yog li no, thaum lub caij kho nrog simvastatin, kua txiv kab ntxwv qaub yuav tsum zam.

Cov lus qhia rau kev siv vasilip (qauv thiab npaum li cas)

Rau cov neeg uas tau sau daim Vasilip, cov lus qhia rau kev siv qhia tias nws tau coj lus, thaum yav tsaus ntuj, 1 sijhawm nyob rau ib hnub.

Kev noj tshuaj li niaj hnub niaj hnub yog 5-80 mg. Raws li txoj cai, 10 mg tau sau tseg. Cov koob tshuaj hloov kho yuav tsum tau nqa nrog lub sijhawm tsawg kawg ntawm 4 lub lis piam. Qhov koob tshuaj rau txhua hnub yuav tsum tsis ntau tshaj 80 mg. Qhov ntau kawg yog muab tsuas yog rau cov neeg mob hnyav hypercholesterolemia lossis ntau dua qhov yuav tshwm sim kev mob plawvCov. Cov lus qhia rau kev siv Vazilip qhia tias cov chav kawm ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob tshwj xeeb hauv txhua kis ntawm tus kheej, nyob ntawm seb muaj dab tsi qhia rau siv thiab ua li cas tus neeg mob zam cov tshuaj.

Tus ntawm hypercholesterolemia tsim nyog rau kev coj ua hypocholesterol noj cov zaub mov thaum kho. Kev muab tshuaj thawj zaug feem ntau yog 10 mg. Rau qhov txo qhov tseem ceeb dua LDL cov roj cholesterol chav kawm tuaj yeem pib nrog 20-40 mg / hnub.

Ntawm homozygous kev mob siab ntsig hypercholesterolemia Feem ntau noj 40 mg lossis 80 mg rau ib hnub, tab sis hauv peb koob (feem ntau 20 mg thaum sawv ntxov thiab yav tav su thiab lwm 40 mg thaum yav tsaus ntuj). Nws raug nquahu los muab cov tshuaj nrog lwm lipid-txostxhais tau tias.

Txhawm rau tiv thaiv kev txhim kho ntawm cov kab mob plawv hauv cov tib neeg muaj kev pheej hmoo siab Ischemic mob plawv tshuaj ntawm 20 mus rau 40 mg / hnub. Qhov ntau npaum ntawm cov tshuaj, ib tus zuj zus xaiv, raug txo yog tias qib LDLtsawg dua 75 mg / dl thiab tag nrho cov roj (cholesterol)tsawg dua 140 mg / dl.

Vasilip tuaj yeem siv nrog ua ke nrog sequestrants ntawm cov kua tsib kua qaubCov. Cov neeg mob kho fibrates lossis nicotinic acid, noj thawj zaug txog 5 mg. Qhov siab tshaj plaws rau kev noj tshuaj txhua hnub yuav tsum tsis pub ntau dua 10 mg. Thiab thaum muab sib xyaw nrog Amiodarone lossis Verapamil tsis pub tshaj kev noj ntau npaum li 20 mg.

Nrog mob hnyav lub raum tsis ua hauj lwm Nws zoo dua tsis pub tshaj li ib koob tshuaj ntawm 10 mg / hnub. Yog tias kev nce ntxiv hauv cov tshuaj tseem yog qhov tsim nyog, tus neeg mob tus mob yuav tsum tau soj ntsuam tas li.

Lwm cov tshuaj sib cuam tshuam:

• gemfibrozil thiab lwm cov fibrates (tsis suav nrog fenofibrate), fusidic acid: muaj peev xwm txhim kho myopathy,
• amiodarone, lomitapide, qeeb calcium calcium blockers (verapamil, diltiazem lossis amlodipine), nicotinic acid nyob rau hauv lipid txo cov tshuaj (tsawg kawg 1000 mg ib hnub): nce ntau ntawm kev tsim myopathy / rhabdomyolysis,
• cov tshuaj tiv thaiv mob nyhav ntawm CYP3A4 isoenzyme (piv txwv li, dronedarone, ranolazine): muaj feem ntau txhim kho myopathy, koob tshuaj Vasilip yuav raug txo,
• OATP1B1 thauj protein inhibitors: nce ntshav ntau dua ntawm simvastatin hydroxy acid thiab qhov ua tau ntawm kev txhim kho myopathy,
• colchicine (hauv cov neeg mob lub raum tsis ua haujlwm): kev pheej hmoo ntawm kev tsim myopathy thiab rhabdomyolysis, kev siv ua ke yuav tsum tau saib xyuas cov neeg mob siab
• tsis ncaj ntawm anticoagulants (coumarin derivatives): kev nce sijhawm hauv prothrombin lub sijhawm, txhais tau tias yog MHO (kev hloov pauv thoob ntiaj teb), tus nqi ntawm qhov ntsuas raug tswj ua ntej pib kho nrog simvastatin, tom qab ntawd nws tau txiav txim siab ntau zaus thaum pib ntawm kev kho, uas tshem tawm qhov hloov pauv hauv MHO. Tom qab mus txog qhov ntsuas pom tseeb ntawm lub sijhawm prothrombin, nws txoj kev txiav txim siab ntxiv yuav tsum tau ua nrog kev cuam tshuam uas pom zoo rau saib xyuas cov neeg mob tau txais kev kho mob anticoagulant. Thaum muaj kev hloov pauv koob tshuaj simvastatin lossis tom qab tshem tawm, kev ntsuas ntsuas tsis tu ncua ntawm qhov ntsuas no tseem raug pom zoo. Hauv cov neeg mob uas tsis noj tshuaj anticoagulants, kev kho mob nrog simvastatin nrog cov tsos ntawm los ntshav los yog pauv hauv lub sijhawm prothrombin tsis cuam tshuam,
• txiv kab ntxwv qaub ua kua (hauv qhov loj): cov ntshav muaj zog ntawm HMG-CoA reductase inhibitors.

Cov lus piv txwv ntawm Vasilip yog: Zokor, Zokor Forte, Simvor, Simvakard, Simvastol, Simlo, Simvastatin Zentiva, SimvaHEXAL, Zovatin, Levomir, Simvalimit, Actalipid, Sinkard, Aterostat, Zorstat, Simvakolat, Simvastatin, Simvastatin, Simvastatin Chaikafarma, Simvastatin-SZ, Simvastatin Alkaloid, Aries, Simvastatin Pfizer.

Cev xeeb tub

Yog li, simvastatin yuav tsum tsis txhob siv los ntawm cov poj niam cev xeeb tub thiab cov poj niam uas tab tom sim ua cev xeeb tub lossis xav tias lawv cev xeeb tub.
Kev lees txais ntawm simvastatin yuav tsum raug ncua rau tag nrho lub sijhawm cev xeeb tub lossis txog thaum muaj kev lees paub tias tus pojniam tsis tau xeeb tub (saib ntu "Contraindications").
Kev siv cov simvastatin hauv cov poj niam thaum lactation yog contraindicated.
Kuj tsis paub meej tias simvastatin lossis nws cov khoom siv roj ntsha hloov mus rau leej niam mis. Txij li ntau yam tshuaj kis rau niam mis thiab muaj qhov ua rau muaj kev phiv loj heev, cov poj niam noj simvastatin yuav tsum tsis txhob pub mis niam. (Saib tshooj "Cov Lus Sib Tham").