Yuav siv cov tshuaj Neyrolipon li cas?

Niam txiv dav, sab hauv 300 thiab 600 mg: mob ntshav qab zib thiab haus dej haus cawv polyneuropathy.

Sab hauv 12 thiab 25 mg: daim siab rog, mob ntsws, mob ntshav siab, mob siab A, intoxication (suav nrog cov ntsev ntawm cov hlau hnyav), lom nrog lub ntsej muag daj, hyperlipidemia (suav nrog kev txhim kho ntawm txoj hlab ntshav atherosclerosis - kev kho thiab tiv thaiv )

Sab sij huam

Los ntawm lub plab zom mov: thaum noj ntawm qhov ncauj - xeev siab, ntuav, mob plab, raws plab.

Kev tsis haum tshuaj: tawv nqaij ua pob khaus, khaus, urticaria, anaphylactic ceeb.

Lwm yam: mob taub hau, cov ntshav qabzib hauv lub cev tsis ua haujlwm (mob ntshav qab zib), nrog kev tswj hwm sai - ncua sij hawm luv luv lossis ua pa nyuaj, nce siab intracranial, ua kom tsis muaj zog, ua kom tsis muaj zog, tsis pom qhov ntshav tawm ntawm daim tawv nqaij thiab cov xoos thiab ua rau lub qhov txhab los ntshav (vim qhov ua haujlwm ntawm cov ntshav khiav tsis zoo )

Tshuaj ntsiav Neurolipon (Neurolipon)

Cov lus qhia rau kev siv tshuaj

• Kev ntsuas rau siv
• Daim ntawv tso tawm
• Pharmacodynamics ntawm cov tshuaj
• Pharmacokinetics ntawm cov tshuaj
• Siv thaum cev xeeb tub
• Cov Yuav Tsum Muaj
• Sab sij huam
• Tsuas tshuaj thiab tswj hwm
• Noj ntau dhau
• Kev sib cuam tshuam nrog lwm yam tshuaj
• Cov kev ceev faj rau kev siv
• Cia rau cov neeg mob
• Hnub tas sij hawm

Nosological kev faib tawm (ICD-10)

Tsuas tshuaj thiab tswj hwm

Hauv / hauv. Cov neeg laus ntawm kev txhaj tshuaj 600 mg / hnub. Sau maj mam - tsis pub ntau tshaj 50 mg / min ntawm thioctic acid (1.7 ml ntawm kev daws rau Txoj kev lis ntshav).

Cov tshuaj yuav tsum tau muab kev tswj hwm los ntawm infusion nrog 0.9% sodium chloride tov ib hnub ib zaug (600 mg ntawm cov tshuaj yog sib xyaw nrog 50-250 ml ntawm 0.9% sodium chloride tov). Hauv cov xwm txheej hnyav, muaj txog li 1200 mg tuaj yeem siv tau. Kev daws teeb meem yuav tsum tau tiv thaiv los ntawm lub teeb los ntawm npog lawv nrog lub teeb npog.

Lub sij hawm ntawm kev kho mob yog los ntawm 2 mus rau 4 lub lis piam. Tom qab ntawd, lawv hloov mus rau kev saib xyuas kev kho mob nrog kev noj cov tshuaj ntawm thioctic acid rau kev tswj hwm qhov ncauj ntawm koob tshuaj 300-600 mg / hnub rau 1-3 hlis. Txhawm rau kom ua tiav cov txiaj ntsig ntawm kev kho mob, nws raug nquahu tias cov chav kawm ntawm kev kho nrog tshuaj Neyrolipon tau nqa tawm 2 zaug hauv ib xyoos.

Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj rau hauv cov menyuam yaus tseem tsis tau txhim tsa.

Daim ntawv tso tawm

Mloog zoo rau kev daws rau kev lis ntshav, 30 mg / ml. Hauv cov iav xim av ampoules, nrog lub nplhaib tawg lossis so taw tes, 10 lossis 20 ml.

5 lossis 10 amp. ua ke nrog ib lub hnab ntawm dub PE zaj duab xis los yog tsis muaj nws hauv pob ntawv ntawm cardboard nrog corrugated liners.

5 amp. hauv lub hlwv ntawm PVC zaj duab xis. 1 lossis 2 bl. nrog ampoules ua ke nrog ib lub hnab ntawm dub PE zaj duab xis lossis tsis muaj nws hauv pob ntawv ntawm cardboard.

Chaw tsim tshuaj paus

PJSC "Ua Liaj Ua Teb". 04080, Ukraine, Kiev, st. Suav Teb Nyab Laj, 63.

Tel./fax: (8-10-38-044) 417-10-55, 417-60-49.

Lub koom haum lees txais kev thov nyiaj los ntawm cov neeg siv khoom: cov chaw sawv cev ntawm cov pej xeem Farmak JSC hauv Russia: 121357, Moscow, ul. Kutuzovsky Kev Pom Zoo, 65.

Xov Tooj: (495) 440-07-58, (495) 440-34-45.

Cov Yuav Tsum Muaj

Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj.

Cev xeeb tub, lub sijhawm ntawm kev pub niam mis (kev paub nrog cov tshuaj tsis txaus).

Cov me nyuam qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv tsis tau tsim).

Ib qho kev tiv thaiv ntxiv rau kev siv Neurolipon nyob rau hauv daim ntawv ntawm tsiav tshuaj yog hereditary galactose intolerance, lactase deficiency lossis glucose-galactose malabsorption.

Cov Tshuaj Hauv Tshuaj

Cov khoom sib xyaw ua ke ntawm Neyrolipon - thioctic acid - yog tsim tawm ncaj qha rau hauv lub cev thiab ua raws li coenzyme hauv oxidative decarboxylation ntawm α-ketonic acids. Lub luag haujlwm tseem ceeb yog ua si los ntawm thioctic acid nyob rau hauv lub zog metabolism ntawm cov hlwb. Nyob rau hauv daim ntawv ntawm lipoamide, cov kua qaub ua cov cofactor tseem ceeb ntawm ntau lub enzyme complex, uas yog lub chaw tsim kev kub ntxhov rau decarboxylation ntawm α-keto acids ntawm Krebs lub voj voog.

Neyrolipon muaj cov antitoxic thiab antioxidant zog, ntxiv rau, thioctic acid tuaj yeem rov ua lwm yam antioxidant, piv txwv li, hauv cov ntshav qab zib mellitus, txo cov tshuaj insulin tsis kam thiab ua rau qeeb ntawm kev txhim kho peripheral neuropathy.

Thioctic acid pab txo cov ntshav piam thaj thiab ntxiv glycogen hauv daim siab. Nws cuam tshuam cov roj metabolism hauv lub cev, koom nrog kev tswj cov metabolism hauv cov rog thiab carbohydrates, txhim kho daim siab ua haujlwm vim hepatoprotective, antioxidant thiab detoxification ua tau zoo.

Cov Tshuaj Pharmacokinetics

Pharmacokinetic cov yam ntxwv nyob ntawm txoj kev ntawm daim ntawv thov:

• qhov ncauj tswj hwm: qhov kev nqus tau tshwm sim nyob rau hauv lub plab (lub plab zom mov) sai thiab ua tiav, thaum noj cov Neurolipon nrog zaub mov noj, kev nqus tau tsawg. Bioavailability yog los ntawm 30 txog 60%, cov tshuaj muaj roj metabolized ua ntej nws nkag mus rau hauv cov kab ke hauv lub cev thaum hla ntawm phab ntsa ntawm txoj hnyuv thiab lub siab (cov nyhuv ua haujlwm dhau thawj). Lub sijhawm kom ncav cuag kev siab tshaj (T_max) sib npaug li 4 μg / ml yog li 30 feeb. Kev mob plab zom mov hauv lub siab tshwm sim los ntawm kev ua kom tawv nqaij ntawm cov caj qaum thiab sib txuas ua ke. Thioctic acid yog tawm hauv cov zis los ntawm ob lub raum: hauv daim ntawv ntawm metabolites - 80-90%, tsis hloov pauv - ib qho me me. T_1/2 (ib nrab-lub neej) yog 25 feeb,
• kev tswj hwm hauv niam txiv: bioavailability yog

30%, metabolism hauv lub siab tshwm sim los ntawm kev ua kom tawv nqaij ntawm ib sab txuas thiab sib txuas ua ke. T_1/2 - 20-50 feeb, tag nrho qhov tshem tawm tau yog

694 ml / min, qhov ntim ntawm kev faib tawm yog 12.7 litres. Tom qab txhaj ib zaug ntawm thioctic acid tso siab, nws kev nthuav tawm los ntawm ob lub raum hauv thawj 3 teev yog nce mus txog 93-97% hauv cov tshuaj uas tsis hloov pauv lossis tshuaj ntxiv.

Cov lus qhia rau kev siv Neyrolipon: txoj kev thiab ntau npaum li cas

Cov tshuaj ntsiav neuroleipone zoo li lub ncauj noj ntawm lub plab (ib nrab teev ua ntej noj mov), tsis tas yuav zom thiab haus nrog ib qho dej me me lossis lwm yam kua nruab nrog cev.

Cov tshuaj pom zoo: 300-600 mg ib hnub ib zaug. Txog kev kho mob ntshav qab zib mob ntshav qab zib kom tsawg thaum pib, niam txiv kev tswj hwm ntawm thioctic acid yog qhov xav tau.

Tus kws kho mob txiav txim siab lub sijhawm ntawm cov chav kawm ntawm kev kho mob ib tus zuj zus.

Mloog zoo rau kev daws rau infusion

Kev daws tau npaj los ntawm mloog zoo Neyrolipon yog tswj los ntawm kev tso ntshav sai (mg 50 mg thioctic acid ib feeb).

Cov tshuaj pom zoo: 600 mg ib hnub ib zaug, hauv cov kis loj, txog li 1200 mg yog tau tso cai.

Txhawm rau npaj qhov kev daws teeb meem, 0.9% NaCl daws yog siv nyob rau hauv ib qho nyiaj ntawm 50-250 ml ib 600 mg ntawm thioctic acid.

Lub sijhawm ntawm cov chav kawm ntawm kev kho mob yog 2-4 lub lis piam, tom qab ntawd lawv hloov mus rau kev saib xyuas kev kho mob nrog thioctic acid nyob rau hauv daim ntawv ntawm lub qhov ncauj npaj (koob tshuaj 300-600 mg ib hnub) rau 1-3 lub hlis.

Txhawm rau kom ua tiav cov nyhuv ntawm Neyrolipona nws raug nquahu kom ua qhov kev kawm ua ntu zus nrog qhov zaus ntawm 2 zaug hauv ib xyoos.

Noj ntau dhau

Cov tsos mob ntawm kev noj haus ntau dhau ntawm thioctic acid thaum noj qhov ncauj yuav ua rau mob taub hau, xeev siab, ntuav, feem ntau ua kom mob, cuam tshuam loj heev hauv cov kua qaub-acid tshuav nyiaj li cas nrog cov kab mob lactic acidosis, hypoglycemic coma, ntshav hnyav coagulation pathologies txog kev tuag.

Txhawm rau kho tus mob, koj yuav tsum tam sim ntawd tsum tsis txhob noj tshuaj, ntxuav lub plab, tom qab ntawd siv lub tshuab hluav ncaig thiab ua cov haujlwm kho.

Tsis paub cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm thioctic acid nrog rau kev tswj hwm ntawm cov niam txiv.

Yog tias koj xav tias yog noj ntau dhau lossis qhov tshwm sim ntawm kev mob tshwm sim loj, koj yuav tsum cuam tshuam nrog Txoj kev lis ntshav, tom qab ntawd, tsis tas yuav tshem tawm txoj kev txhaj tshuaj, maj mam qhia 0.9% isotonic NaCl daws los ntawm lub system. Cov tshuaj tsis muaj ib qho tshuaj tua tshwj xeeb;

Cov lus qhia tshwj xeeb

Txoj kev lis ntshav daws teeb meem uas muaj thioctic acid yuav tsum muaj kev tiv thaiv los ntawm lub teeb los ntawm npog cov ntim nrog cov ntaub thaiv.

Hauv kev kho mob ntawm cov neeg mob ntshav qab zib, yuav tsum tau soj ntsuam cov ntshav qabzib ntau zaus, qee zaum, yog tias tsim nyog, kev kho cov tshuaj ntshav qog ntshav txhawm rau txhawm rau tiv thaiv kev txhim kho ntshav qab zib.

Thaum kho nrog Neurolipone, ib qho yuav tsum tsis txhob haus cov dej qab zib uas muaj cawv, txij li thaum ethanol inhibits nws txoj haujlwm kho.

Yeeb tshuaj sib cuam tshuam

• glucocorticosteroids: thioctic acid ua rau lawv cov hauj lwm tiv thaiv kev txhim kho,
• cisplatin: qhov txo qis hauv nws cov txiaj ntsig kho tau sau tseg,
• cov tshuaj muaj hlau (hlau, hlau, calcium npaj): thioctic acid khi cov hlau, yog li ntawd, lawv cov kev coj ua ib txhij yuav tsum raug zam, nws yog ib qho tsim nyog kom muaj kev sib nrug ntawm cov koob tshuaj tsawg kawg 2 teev,
• insulin los yog qhov ncauj hypoglycemic tus neeg sawv cev: thioctic acid tuaj yeem ua rau lawv cov txiaj ntsig,
• ethanol thiab nws cov metabolites: inhibit qhov kev txiav txim ntawm thioctic acid.

Txoj kev lis ntshav ntawm Neyrolipon cov ntaub ntawv tsis yog kev sib xyaw ua ke nrog cov suab thaj, yog li ntawd nws tsis sib haum nrog cov kev daws ntawm Ringer, piam thaj, thiab fructose. Nws kuj tseem tsis sib haum nrog cov kev daws teeb meem ntawm cov khoom sib txuas uas cuam tshuam nrog SH-pawg lossis disulfide choj thiab kev npaj muaj ethanol.

Kev txheeb xyuas txog neuroleepone

Kev txheeb xyuas txog neuroleepone muaj kev sib cav heev. Rau qee tus neeg mob, cov tshuaj tsis haum, nws raug xa mus ua qhov tsis muaj txiaj ntsig uas ua rau me ntsis txo cov tsos mob ntawm tus kab mob thiab ua rau muaj kev phiv tshuaj hnyav.

Hauv ntau qhov kev txheeb xyuas lwm tus, neurolypone tau sau tseg tias tshuaj ntawm kev xaiv vim qhov tsis muaj qhov tshwm sim tsis zoo thiab ua haujlwm siab.

Tus nqi ntawm Neyrolipon hauv cov khw muag tshuaj

Kwv yees tus nqi rau NeroLipone:

• mloog zoo rau kev npaj ntawm kev daws rau kev lis ntshav (5 ampoules hauv ib pob ntawm cardboard): hauv ampoules ntawm 10 ml - 170 rubles, hauv ampoules ntawm 20 ml - 360 rubles,
• tsiav tshuaj (10 pcs. hauv blisters, 3 blisters hauv ib pob ntawv ntawm cardboard) - 250 rubles.

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Kev daws rau Txoj kev lis ntshav yog muab tshuaj rau cov laus rau ntawm 600 mg ib hnub twg. Nws muab tshuaj qeeb qeeb - tsis ntau tshaj 50 mg ntawm thioctic acid (1.7 ml ntawm kev daws rau Txoj kev lis ntshav) ib feeb.

Cov tshuaj yuav tsum tau muab kev tswj hwm los ntawm infusion nrog 0.9% sodium chloride tov 1 zaug hauv ib hnub (600 mg ntawm cov tshuaj yog muab sib xyaw nrog 50-250 ml ntawm 0.9% sodium chloride tov). Hauv cov xwm txheej hnyav, muaj txog li 1200 mg tuaj yeem siv tau. Kev daws teeb meem yuav tsum tau tiv thaiv los ntawm lub teeb los ntawm npog lawv nrog lub teeb npog.

Lub sij hawm ntawm kev kho mob kav ntev li 2 txog 4 lub lim tiam. Tom qab ntawd, lawv hloov mus rau kev saib xyuas kev kho mob nrog Neyrolipon rau kev tswj hwm qhov ncauj (tsiav tshuaj) ntawm koob tshuaj 300-600 mg ib hnub rau 1-3 hlis. Cov tshuaj ntsiav tau noj ntawm qhov ncauj tsis tau ntxo, ntxhua nrog cov kua me me, 30 feeb ua ntej noj mov (ntawm lub plab khoob). Txhawm rau kom ua tiav cov txiaj ntsig ntawm kev kho mob, ib chav kawm ntawm txoj kev kho raug pom zoo 2 zaug hauv ib xyoos.

Lub sijhawm tiv thaiv yog txiav txim los ntawm tus kws kho mob.

Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj rau hauv cov menyuam yaus tseem tsis tau txhim tsa.

Pharmacological kev txiav txim

Thioctic acid, uas yog ib feem ntawm Neuroleipon, yog cov khoom hauv lub cev ua haujlwm thiab ua lub coenzyme hauv oxidative decarboxylation ntawm alpha keto acids, thiab ua lub luag haujlwm tseem ceeb hauv lub zog metabolism hauv lub cell. Hauv daim foos (lipoamide) nws yog qhov tseem ceeb cofactor ntawm ntau lub enzyme ntau qhov uas catalyze decarboxylation ntawm Krebs alpha-keto acids. Thioctic acid muaj cov tshuaj tiv thaiv antitoxic thiab antioxidant, nws kuj tseem tuaj yeem tsim lwm cov antioxidant, xws li mob ntshav qab zib. Hauv cov neeg mob ntshav qab zib, thioctic acid txo qis insulin tsis kam thiab inhibits kev txhim kho peripheral neuropathy.

Nws pab txhawm rau ua kom tsis txhob muaj cov ntshav qabzib hauv cov ntshav ntshav thiab kev sib txuam ntawm glycogen hauv lub siab. Thioctic acid cuam tshuam rau cov metabolism ntawm cov roj cholesterol, koom nrog kev tswj hwm ntawm lipid thiab carbohydrate metabolism, txhim kho daim siab ua haujlwm (vim yog hepatoprotective, antioxidant, detoxification effect).

Kev sib txuam

Txhim kho cov tshuaj tiv thaiv ntawm glucocorticosteroid tshuaj.

Nrog rau kev tswj hwm ib txhij ntawm thioctic acid thiab cisplatin, qhov txo qis hauv kev ua haujlwm ntawm cisplatin tau sau tseg.

Thioctic acid khi cov hlau, yog li ntawd, nws yuav tsum tsis txhob siv cov tshuaj muaj hlau (piv txwv li hlau, magnesium, calcium) - lub sijhawm nruab nrab ntawm cov tshuaj yuav tsum yog tsawg kawg 2 teev.

Nrog rau siv ua ke ntawm thioctic acid thiab insulin los yog tshuaj ntawm qhov ncauj hypoglycemic, lawv cov nyhuv tuaj yeem ua kom zoo dua.

Cawv thiab nws cov metabolites tsis muaj zog ntawm cov nyhuv neuroleipone.