Fluvastatin: cov lus qhia rau kev siv, ceeb toom thiab tshuaj xyuas

Fluvastatin ua raws li kev sib tw inhibitor HMG-CoA reductaseCov. Tiv thaiv kom tsis txhob tig GMG-CoA hauv mevalonateuas yog tus thawj ua ntej sterols thiab rojCov. Hauv qab ntawm qhov tshuaj no, cov roj (cholesterol) hauv cov hepatocytesreceptor synthesis yog kho kom zoo tsawg lipoprotein ceev thiab particle ntes LDL.

Raws li koj paub, nrog nce roj, theem griglycerides thiab apolipoprotein B, tus neeg raug txhim kho atherosclerosisCov. Raws li kev tshawb fawb txog kev mob sib kis, kev tuag thiab kev mob hlwb los ntawm kab mob plawv, cov hlab ntshav ncaj qha nyob ntawm qib LDL cov roj cholesterol thiab tag nrho cov cholesterol. Nrog kev nce qib ntawm cov lipoproteins ntau ntom nti, kev tuag ua kom qis dua. Cov tshuaj tsis muaj qhov cuam tshuam rau qib ntshav fibrinogen thiab lipoprotein a.

Cov cuab yeej tsis muaj liaj teb. muaj kev cuam tshuam zoo rau kev tsim cov tshuaj hormones steroid los ntawm gonads thiab qog adrenal. Txawm li cas los xij, thaum lub sijhawm kho nrog fluvastatin, cov neeg mob uas muaj kev cuam tshuam loj heev ntawm endocrine kawg yuav tsum ua tshwj xeeb thiab saib xyuas.

Tom qab lub qhov ncauj tswj hwm ntawm tsiav tshuaj nrog tshuaj, nws yog kiag li thiab sai sai nyob rau hauv cov hnyuv. Kev siab tshaj plaws yog tiav hauv 60 feeb. Qhov nruab nrab ntawm kev siv bioavailability yog 24%. Cov tshuaj muaj cov nyhuv ntawm "thawj zaug dhau" los ntawm nplooj siab. Nrog kev txhaj tshuaj, cov nyhuv no tsis pom. Tom qab qhov ncauj tswj hwm ntawm cov ntsiav tshuaj daim ntawv hauv qhov tshuaj 80 mg mg, qhov siab tshaj plaws hauv cov ntshav tau pom tom qab 3 teev. Bioavailability yog 29%. Noj cov khoom noj muaj roj ua kom lub cev ntau dua ntawm cov khoom noj.

Qib ntawm kev khi ntawm tus neeg sawv cev rau cov ntshav plasma protein = 98%. Hauv lub siab, cov tshuaj undergoes oxidation kev rov tiv thaiv thiab N-dealkylationCov. Nws yog tawm nrog cov quav, nyob rau hauv daim ntawv ntawm metabolites, me ntsis - tsis hloov. Ib nrab-lub neej tom qab noj cov ntsiav tshuaj yog txog 9 teev. Hauv cov neeg mob uas muaj kab mob siab, fluvastatin tuaj yeem nthuav tawm, thiab cov ntshav plasma concentration ntawm cov tshuaj thiab AUC nce.

Kev ntsuas rau siv

Cov tshuaj yog raug pom zoo rau kev siv los ntawm cov neeg mob laus:

• nrog rau kev nce qib ntawm qhov dav dav roj, triglycerides, cov roj lipoprotein tsawg kawg, apolipoprotein Bntawm thawj hypercholesterolemia thiab hyperlipidemia,
• nrog mob plawv plawv kom qeeb ntawm qhov txheej txheem muaj mob atherosclerosis,
• raws li ib tug prophylactic nrog Ischemic mob plawvtom qab angioplasty.

Fluvastatin muab tshuaj rau cov menyuam yaus thiab cov hluas ua ib feem ntawm cov kev kho mob nyuaj ntawm ib qib siab roj, apolipoprotein B thiab LDL cov roj cholesterolnrog heterozygous tsev neeg hypercholesterolemia.

Cov Yuav Tsum Muaj

Cov tshuaj yog contraindicated rau kev siv:

• ntawm tshuaj tsis haum,
• hauv cov neeg mob uas muaj kab mob siab,
• nrog rau qhov nce hauv qib ntawm daim siab enzymes uas tsis paub keeb kwm,
• thaum cev xeeb tub,
• nyob rau hauv cov menyuam yaus hnub nyoog qis dua 10 xyoo,
• thaum pub niam mis.

Sab sij huam

Cov kev mob tshwm sim hauv qab no yuav tshwm sim thaum kho fluvastatin:

Tsis tshua pom muaj: rhabdomyolysis, kab mob siab, mob mob vwm, gynecomastiakev cuam tshuam lub qog ua haujlwm thiab qog adrenal.

Noj ntau dhau

Thaum tswj hwm cov tshuaj hauv ib zaug tsuas siv txog 80 mg, qhov teeb meem loj tshwm sim los ntawm kev saib xyuas tsis pom. Yog tias cov neeg mob tau noj tshuaj rau hauv cov qauv ntawm cov ntsiav tshuaj nrog rau kev tso tawm ntev ntev ntawm kev noj tshuaj 640 mg rau 14 hnub, cov kev mob tshwm sim los ntawm kev mob plab tau tshwm sim, ntshav ntau ntawm transaminases, ALT, thiab AST nce ntxiv.

Cov tsos mob kho, lim ntshav ua tsis tau zoo.

Kev sib txuam

Isoenzymes koom tes hauv cov metabolism hauv cov tshuaj. cytochrome P450, CYP2C9, CYP2C9, CYP3A4Cov. Yog tias ib qho ntawm txoj kev ntawm cov metabolism thiab tshem tawm cov tshuaj tsis yooj yim sua, lub peev xwm tuaj yeem them taus los ntawm lwm qhov.

Nws tsis pom zoo kom muab cov tshuaj nrog cov tshuaj inhibitorsHMG-CoA reductase.

Substrates thiab system inhibitors CYP3A4, erythromycin, cyclosporin, intraconazole muaj cov nyhuv me dhau ntawm qhov kev siv pharmacokinetic ntawm cov tshuaj. Thaum muab sib xyaw nrog phenytoin ntshav ntau ntawm cov tshuaj ntau ntxiv.

Pom zoo kom coj colestyramine 4 teev tom qab fluvastatin kom nce ntxiv cov nyhuv ntxiv ntawm cov tshuaj.

Nrog kev siv tshuaj ua ke nrog phenytoin kev qhia yuav tsum tau ceeb toom; kev kho kom haum yuav tau. Qhov kev sib xyaw no ua rau muaj qhov nce ntxiv ntawm plasma ntau ntau ntawm fluvastatin thiab phenytoin.

Ib txhij tuav tswj ntawm yam khoom nrog diclofenac ua rau muaj kev nce ntshav ntau ntxiv thiab Auc xeem ib.

Cov tshuaj tuaj yeem tuaj yeem ua ke nrog tolbutamide, losartan.

Mob muag mob ntshav qab zibleej twg noj fluvastatin thiab glibenclamide, yuav tsum tau ceev faj tshwj xeeb, yog nyob ntawm kev saib xyuas ntawm tus kws kho mob, tshwj xeeb tshaj yog nrog kev nce ntau ntxiv ntawm niaj hnub tshuaj fluvastatin mus rau 80 mg rau ib hnub.

Thaum muab cov tshuaj sib txuas nrog ranitidine, cimetidine thiab omeprazole muaj qhov nce ntxiv ntawm qhov siab tshaj plaws plasma concentration thiab AUC ntawm cov tshuaj, thaum lub plasma tshem ntawm Fluvastatin txo qis.

Hauv kev kho mob ntawm cov neeg mob uas tau noj ntev rifampicinkev loj hlob tseem ceeb pom Auc thiab Cmax.

Nrog ceev faj, muab cov tshuaj no sib xyaw nrog cov tshuaj tiv thaiv ntawm cov tshuaj warfarin. Nws raug nquahu kom kuaj xyuas lub sijhawm prothrombin kom sai, yog tias tsim nyog, kho qhov ntau npaum li cas.

Cov lus qhia tshwj xeeb

Ua ntej pib txoj kev kho mob, nws yog ib qho tsim nyog los tsim kho tus neeg mob daim tawv nqaij ntawm tus kheej, tag nrho roj, triglycerides thiab HDL rojCov. Tsis suav cov xwm txheej ob hyperlipidemia, mob ntshav qab zib mellitus, hypothyroidism, dysproteinemia, cov tsos mob nephroticdaim siab mob quav cawv.

Hauv ib hlis, nws pom zoo kom ntu txiav txim siab seb cov qib ntawm cov lipids thiab kho qhov ntau npaum li cas, nyob ntawm qhov ntsuas cov neeg siv.

Thaum ua ke nrog fluvastatin nrog cholestyramine thiab lwm yam tshuaj zoo sib xws, nws raug nquahu kom coj nws thaum hmo ntuj.

Npaj uas muaj (Ib Leeg)

Lub npe lag luam ntawm cov tshuaj: Leskol, Leskol Forte.

Kev txheeb xyuas txog cov tshuaj no txawv. Rau qee qhov, cov tshuaj tshwm sim dhau los, lawv tau pom tias muaj txiaj ntsig zoo ntawm kev kho, rau qee yam, cov tshuaj tsis pab txhua.

• “... Kuv tau coj cov tshuaj hauv kev sib xyaw nrog lwm cov tshuaj, ua raws kev noj haus. Cov nyhuv tau zoo. Tab sis sai li nws tau muab tso tseg, txhua yam rov qab”,
• “... Ib qho kho mob dubious, raws li rau kuv. Nws zoo nkaus li tias tsuas yog cov nyiaj tau pumped tawm ntawm cov neeg mob, tsis ua hauj lwm zoo. Nws yog qhov zoo dua rau haus atorvastatin”,
• “... Thaum lawv sau cov tshuaj no rau kuv, lawv tau qhia kuv tam sim ntawd hais tias kuv yuav tsum hloov kuv lub neej kev ua neej thiab ua raws li kev noj haus, txwv tsis pub yuav tsis muaj kev nkag siab zoo. Nws pib kev kho, qhov kev ntsuas tau zoo dua. Tsis muaj cov nyom tshwm sim, Kuv xav zoo”.

Fluvastatin tus nqi, qhov twg yuav

Tus nqi ntawm 28 ntsiav tshuaj ntawm cov tshuaj Leskol, nrog qhov ntau npaum ntawm 80 mg txhua qhov yog txog 2800 rubles.

Kev Kawm: Nws kawm tiav hauv Rivne State Basic Medical College nrog kev kawm tiav qib hauv Tshuaj. Nws kawm tiav hauv Vinnitsa State Medical University. M.I. Pirogov thiab ib qho kev xyaum ua haujlwm raws nws.

Kev: Los ntawm 2003 txog 2013, nws ua haujlwm ua tus kws muag tshuaj thiab yog tus thawj coj ntawm lub tsev muag tshuaj kiosk. Nws tau txais ntawv thiab cov kev sib txawv rau ntau xyoo ntawm consciousious kev ua haujlwm. Cov lus qhia txog cov ncauj lus kev kho mob tau raug luam tawm hauv cov ntawv tshaj tawm hauv zos (ntawv xov xwm) thiab ntawm ntau qhov Internet portals.

Muaj pes tsawg leeg thiab noj ntau npaum

• Fluvastatin sodium.
• Magnesium stearate.
• Sodium bicarbonate.
• MCC.
• Talc.
• Pob kws nplej siab.
• Calcium carbonate.
• Titanium dioxide.
• Hlau oxide.
• Nkaws
• Shellac.
• Cov khoom noj xim.
• Opadry (sib xyaw rau thov ib zaj duab xis txheej).

Dosage cov ntaub ntawv ntawm fluvastatin yog cov ntsiav tshuaj uas muaj cov fluvastatin sodium ntsev, lossis tshuaj ntsiav daim ntawv ntawm kev tso tawm sai. Cov tshuaj txau muaj cov hmoov zoo gyroscopic. Cov ntsiav tshuaj yog daj lossis dawb. Cov tshuaj yog zoo soluble hauv dej, ethanol, methanol. Nws muaj xws li cov chaw muag tshuaj raws li cov nyhuv hypocholesterolemic (hauv cov ntshav, fluvastatin txo qis roj cholesterol). Lub npe Latin hauv cov ntawv qhia tuaj yeem sau tau Fluvastatinum (genus Fluvastatini). Npaj rau kev siv lub qhov ncauj.

Fluvastatin, raws li cov lus qhia, raug cais tawm los ntawm daim siab txog li 90%, los ntawm cov kab mob genitourinary mus txog 10%. Yog li no, cov txheej txheem cov tsub zuj zuj hauv lub cev yog qhov tsawg txawm tias siv ntev. Fluvastatin yog yeeb tshuaj los ntawm pab pawg ntawm reductase inhibitors. Cov tshuaj qaug tshuaj ntawm cov tshuaj ua raws li inhibitor (ua kom qis) ntawm cov cholesterol nyob rau hauv tib neeg lub cev.

Cov tshuaj yog xaiv los ntawm cov kws kho mob koom nrog qhov xav txog tus yam ntxwv ntawm tus neeg mob thiab cov lus qhia. Cov tshuaj Analogues los ntawm cov pab pawg neeg statins tuaj yeem kho, piv txwv, nyob hauv kev lag luam npe lovastatin, atorvastatin. Nws yog txwv tsis pub ywj siab los xaiv cov tshuaj rau koj tus kheej.

Sab sij huam

Nws feem ntau ua tau zoo, tab sis xws li kev phiv yog ua tau nrog kev teem caij ntawm fluvastatin (tso tawm hauv cov lus qhia):

• Lub plab zom mov chim (xeev siab, mob plab, pancreatitis, kem plab, mob plab, quav tawv).
• Pw tsis tsaug zog.
• Mob taub hau.
• Nkees, kev nyuaj siab.
• Kev ua tsis taus nyob rau hauv cov ntshav ncig thiab lymphatic.
• Kev ua xua (qhov tawv nqaij ua pob, urticaria. Tsis tshua muaj - anaphylactic kev xav.)
• Kev ua txhaum ntawm lub nkoj.
• Ua tsis txaus siab nyob rau hauv daim siab.
• O o. (ntau zaus - ntsej muag, tsis tshua muaj - Quincke's edema).
• Nqaij tsis muaj zog, mob caj dab.
• Kev ua txhaum ntawm lub cev ntawm qhov chaw mos (erectile kawg, kev sib deev muaj zog tsawg dua).
• Cov teeb meem hauv kev ua haujlwm ntawm cov qog mammary.
• Malfunctions ntawm lub qog ua haujlwm thiab lub qog adrenal.
• Cov tsos ntawm cov teeb meem hauv cov txheej txheem ua pa (mob ntsws, mob ntsws).
• Qhov tshwm sim ntawm kev tsis sib haum xeeb hauv cov kab mob genitourinary system (mob txeeb zig).

Tag nrho cov tsos mob saum toj no tuaj yeem tshwm sim nrog kev noj tshuaj ntau dhau. Hauv qhov no, kev pab yog tsos mob. Txhua qhov mob yuav tsum qhia koj tus kws kho mob.

Fluvastatin tau txais kev noj qab haus huv rau cov neeg tuaj yeem noj qab haus huv los txiav txim txog kev phiv. Ntawm tib qhov ntau kawg nkaus ntawm 80 mg rau hauv daim ntawv ntawm tsiav tshuaj, tsis muaj teeb meem pom tshwm sim muaj kev puas tsuaj tau raug kuaj pom. Thaum fluvastatin tau siv rau hauv ntev ntev (ntev ntev), cov kev mob tshwm sim saum toj no tau pom.

Cov lus qhia rau kev siv

Fluvastatin raws li cov lus qhia tau sau tseg rau cov neeg laus thiab menyuam yaus hnub nyoog ntau dua 10 xyoo. Tab sis cov menyuam ntxhais tau pom zoo kom noj tom qab qhov pib ntawm coj khaub ncaws, txij li tsis tau muaj kev tshawb nrhiav txog cov nyhuv ntawm cov tshuaj rau poj niam txiv neej cov tshuaj hormones.

Cov txheej txheem ntawm kev kho mob yuav tsim los ntawm tus kws kho mob koom nrog, raws li cov lus qhia. Feem ntau, cov neeg mob tau raug xaj li 20 mus rau 40 mg ib hnub ib zaug nyob rau yav tsaus ntuj, txij li cov roj (synthesis) tseem ceeb thaum hmo ntuj. Fluvastatin ywj pheej ntawm kev ua zaub mov noj. Ua ntej pib txoj kev kho mob, tus neeg mob pauv mus rau cov zaub mov tshwj xeeb kom txo cov roj (cholesterol).

Qhov siab tshaj plaws ua tiav tau li ntawm 24 hnub txij li kev pib noj tshuaj. Thaum lub sijhawm kho tag nrho, HDL feem pua ​​(cov kua roj lipoproteins ntau) hauv cov ntshav yuav tsum tau saib xyuas los kho cov tshuaj ntau npaum li cas. Kev txiav txim siab ntawm fluvastatin mob tsawv rau lub sijhawm ntev nrog kev siv lub sijhawm ntev.

Kev noj tshuaj raws li cov lus qhia, kom txo LDL mus rau 25%: 1 tshuaj ntsiav (40 mg) lossis 1 ntsiav tshuaj (80 mg) ib hnub. Lossis 2 tsiav tshuaj ib hnub ob zaug, raws li cov lus qhia thiab cov lus qhia ntawm tus kws kho mob tuaj koom. Thawj koob tshuaj rau cov menyuam yaus yog 20 mg. Yog tias muaj phiv, ces koj yuav tsum qhia koj tus kws kho mob tam sim ntawd. Nws raug nquahu kom cuam tshuam kev kho mob nrog fluvastatin thaum tswj kev phiv rau ib lub lim tiam. Hauv qhov no, so ob-lub lim tiam yog tsim thiab tsuas yog tom qab lub sijhawm no tau dhau mus, cov tshuaj analogues ntawm lwm cov statins yog tshuaj rau tus neeg mob (piv txwv li, lovastatin).

Siv thaum cev xeeb tub

Fluvastatin, raws li cov lus qhia, raug txwv thaum cev xeeb tub. Cov kev tshawb fawb txog qhov tseeb ntawm kev siv 40 mg sodium fluvastatin hauv kev kho mob hauv hom poj niam no tsis tau ua. Cov neeg sawv cev ntawm reductase txo cov kev sib txuas ntawm cov roj (cholesterol) thiab, feem ntau, kuj tseem txo cov kev sib txuas ntawm lwm cov roj ntsha sib xyaw ua ke tseem ceeb rau tus me nyuam hauv cov roj (cholesterol), nws tuaj yeem ua txhaum kev txhim kho ntawm tus me nyuam thaum nws tau hais rau cov poj niam hauv txoj haujlwm.

Cov poj niam tau sau tshuaj fluvastatin tsuas yog tias lub sijhawm muaj peev xwm xeeb tub yog qhov tsis lees paub. Yog tias kev xeeb tub tshwm sim thaum kho, tom qab ntawd noj cov tshuaj yuav tsum nres tam sim ntawd thiab qhia koj tus kws kho mob txog qhov no kom kho kev kho mob ntxiv. Thaum lub sijhawm lactation, nws kuj tseem raug txwv, vim tias nws nkag mus rau leej niam cov kua mis thiab ntshav ntshav.

Txog hnub nyoog 9 xyoos, fluvastatin yog contraindicated. Rau cov menyuam muaj hnub nyoog, noj ntau npaum li cov lus qhia, raws li tus kws kho mob tau teem tseg. Fluvastatin tau sau tseg rau cov menyuam yaus (cov menyuam ntxhais nrog pib lub cev ntas) thiab cov hluas ua ib feem ntawm kev kho mob dav ntxiv rau cov roj (cholesterol), apoliprotein B thiab LDL cov roj cholesterol, nrog heterozygous tsev neeg hypercholesterolemia ua ke nrog kev kho kev noj haus. Tsis muaj ntawv tshaj tawm txog kev sim kho cov ntaub ntawv hais txog kev siv cov menyuam yaus hnub nyoog qis dua 9 xyoos.

Cov cim ntawm fluvastatin

Cov yeeb yaj kiab ntawm Fluvastatin yog Leskol thiab Leskol Forte. Lawv muaj cov nyhuv zoo sib xws. Lub cim tshiab ntawm statins suav nrog Simvastatin lossis Atorvastatin. Lawv muaj cov nyhuv ntev dua, tab sis txhua tus muaj cov yam ntxwv ntawm tus kheej, thiab lawv nkag mus yuav tsum nruj me ntsis raws li cov lus qhia, tom qab xaiv tus kws kho mob.

Kev Siv Tshuaj Xyuas

Kev txheeb xyuas txog cov tshuaj muaj ntau yam sib txawv, ib tug neeg tuaj nrog tshuaj, ib tus neeg yuav tsum hloov nws.

Neeg mob Plato 35 xyoo: "Cov tshuaj tau sau ntawv rau kuv los ntawm tus kws kho mob endocrinologist thaum nws pom tias kuv tau nce cov roj (cholesterol) thiab qhov taw qhia ntawm triglycerides. Nws kuj tau xa kuv mus noj zaub mov nruj. Hauv thawj peb lub lis piam, cov txiaj ntsig tau tsawg heev, tab sis thaum kawg ntawm lub lim tiam thib plaub, qhov ntsuas tau zoo dua, theem ntawm lipids thiab triglycerides poob qis. Kuv, zoo siab ntawm qhov no, nres saib xyuas kuv kev noj haus, tab sis Fluvastatin haus ntxiv. Rau ob peb lub hlis kuv tau txais phaus ntxiv, tab sis cov ntawv xeem tau zoo. Tus kws kho mob pom tau hais tias kuv tsum tsis txhob noj zaubmov noj zaub mov, cem kuv. Tom qab ntawd, Kuv tau pib soj ntsuam nruj yam uas tau sau rau hauv cov lus qhia, tag nrho cov lus pom zoo ntawm tus kws kho mob thiab tus neeg noj zaub mov. Kuv tau raug kho thiab vim li ntawd, kuv tsis tau haus Fluvastatin mus ib xyoos tam sim no, tab sis kuv tseem ua raws li kev noj zaub mov zoo thiab kev tawm dag zog (tseem muaj kws kho mob pom zoo). Txhua qhov kev xeem yog qhov qub. ”

Neeg mob Tatyana 40 xyoo: “Thawj zaug kuv nqa atorvastatin raws li sau hauv cov lus qhia. Nws muaj cov kev mob tshwm sim loj heev, thiab tus kws kho mob tau hloov rau fluvastatin, piav qhia tias nws muaj kev nyab xeeb dua thiab muaj kev tiv thaiv zoo dua. Nyob rau tib lub sijhawm haus cawv fenofibrate txhawm rau txhim kho cov nyhuv. Tam sim no kuv tseem tab tom kho, kuv cov kev ntsuam xyuas tau zoo zuj zus. Nyob rau hauv parallel, Kuv pib noj cai, noj mus rau hauv tus account lub tswv yim ntawm tus kws qhia noj haus thiab koom nrog kev tawm dag zog kev tawm dag zog. Nws zoo. Tsis muaj kev cuam tshuam dab tsi rau kuv ntxiv lawm. ”

Tus kws kho mob yog tus kws kho mob endocrinologist. Tolstolobov Vadim Petrovich 50 xyoo: "Ua ntej, nws tau muab tshuaj atorvastatin rau nws cov neeg mob yog cov tshuaj tshiab dua uas muaj cov nyhuv ntev. Tab sis qee tus neeg mob tau tshaj tawm los ntawm cov tshuaj no. Tom qab nws tshem tawm txoj haujlwm, thiab ib qho kev txiav txim siab tu ncua, Fluvastatin tshuaj.Tsis muaj kev cuam tshuam dab tsi rau kuv txoj kev xyaum hauv cov neeg mob. Txhawm rau txhim kho cov nyhuv ntxiv, kuv sau nws nrog fenofibrate. "

Kev siv tshuaj kho nrog fluvastatin yog tus kws kho mob sau tseg, raws li cov lus qhia, tom qab tsis muaj pov thawj kho nrog kev noj zaub mov noj thiab kev tawm dag zog. Noj Fluvastatin kuj tsis yog ib qho tsis kam rau kev noj zaub mov kom zoo, cov vitamins thiab tawm dag zog lub dag lub zog. Nws ua tau zoo tshaj yog tias tus neeg mob yuav ua lub neej noj qab nyob zoo.

Cov ntsiab lus rau kev teem caij fluvastatin

Cov tshuaj Fluvastatin, kws kho mob kho mob, ua kom muaj kev kho mob rau cov kab mob thiab kev cuam tshuam hauv lub cev ntawm tus neeg mob:

• Thawj hom kabmob yog qhov siab lipid hauv cov ntshav hypercholesterolemia,
• Atherogenic hom pathology dyslipidemia ntawm thawj thiab thib ob hom kev loj hlob,
• Nrog ib tus kab mob ntawm cov qog ntawm cov hlab ntsha, atherosclerosis hauv txhua qhov kev tshwm sim. Thaum noj Fluvastatin, nws yog qhov tsim nyog rau tus neeg mob kom noj cov vitamins, ntxiv rau cov kab kawm thiab cov zaub mov me me,
• Nrog ib qho kab mob ntawm cov kabmob hauv nruab nrog cev, hom 2 mob ntshav qab zib mellitus.

Hauv kev tiv thaiv kev tiv thaiv, fluvastatin inhibitor yog tshuaj txhawm rau tiv thaiv cov pathologies:

• Txhawm rau tiv thaiv txoj kev ntshav siab mus rau hauv cov neeg mob ntshav siab,
• Txhawm rau tiv thaiv myocardial infarction, as Well as cerebral ischemia (mob hlab ntsha tawg) thiab mob hlwb txhaws,
• Txhawm rau tiv thaiv cov kab mob hauv lub plawv thiab cov ntshav khiav,
• Txhawm rau tiv thaiv txoj kev loj hlob ntawm pathology, mob ntshav qab zib mellitus, nrog cov teeb meem metabolic tshwm sim los ntawm kev rog dhau heev lawm.

Hypercholesterolemia

Tsuas tshuaj thiab tswj hwm

Ua raws li cov lus qhia rau kev siv, kev noj tshuaj ntawm statin pawg Fluvastatin tuaj yeem kho rau txhua pawg neeg cov neeg laus dua 10 xyoo. Txhawm rau xaj cov tshuaj no, koj xav tau daim ntawv yuav tshuaj los ntawm koj tus kws kho mob.

Tib qho xwm txheej rau kev noj tshuaj tsuas yog tias ua ntej noj tshuaj Fluvastatin, nws yog qhov tsim nyog kom tus neeg mob yauv yauv tawm kev tiv thaiv kab mob, uas yuav pib cov txheej txheem ntawm cov lipoprotein index hauv lub cev.

Qhov kev noj haus zoo li no tseem tau pom thaum lub sijhawm kawm tshuaj kho mob nrog Fluvastatin, thiab yog tias tsim nyog, nws tuaj yeem txuas ntxiv txawm tias tom qab qhov kawg ntawm kev siv tshuaj.

Fluvastatin ntsiav tshuaj noj ntawm qhov ncauj, tsis hais tus neeg mob noj lub sijhawm no lossis tseem tsis tau noj zaub mov. Qhov txawv txav ntawm kev noj cov tshuaj statins yog qhov lawv pom zoo kom noj thaum tib lub sijhawm.

Lub cim ntawm cov tshuaj fluvastatin

Qhov muab tshuaj rau noj cov fluvastatin cholesterol index yog qhia hauv qab no:

• Txhawm rau kom txo qis cov roj molecular phaus roj tsawg li 25.0%, nws yuav tsum noj 1 lub tshuaj nrog noj 40.0 milligrams, lossis 80.0 milligrams ib hnub ib zaug thiab zoo dua rau yav tsaus ntuj,
• Txhawm rau txuas ntxiv kom txo qis cov roj (index) thiab txo qis kom tsawg dua 25.0%, tom qab ntawd lawv tau raug xaj kom noj 20.0 milligrams 1 ntsiav tshuaj ib hnub rau thawj zaug, thiab tom qab ntawd nce cov tshuaj rau 80.0 milligrams ib hnub.

Qhov siab tshaj plaws ntawm cov tshuaj statins rau ntawm lub cev tshwm sim tom qab 30 hnub ntawm kev ua yeeb tshuaj. Fluvastatin tau tsis muaj kev zam thiab tseem qhia tau tias qhov siab tshaj plaws ua tau rau kev txo qis lipoprotein Performance index tom qab ib hlis ntawm kev kho mob.

Txhawm rau ua kom cov nyhuv ntawm kev txo qis lipids, kev kho mob ntev dua yuav tsum ua kom qis qhov kev nqus ntawm cov roj molecules hauv cov ntshav.

Thawj qhov kev siv tshuaj txhua hnub hauv cov menyuam yaus txij thaum 10 xyoo yog 20.0 milligrams.

Cov tshuaj no tau tawm hauv lub cev sab nraud nrog kev pab ntawm daim siab thiab kab mob hlwb.

Yog li, cov neeg mob uas tau mob raum, tsis tas yuav muaj kev kho kom haum tshwj xeeb ntawm cov tshuaj fluvastatin.

Pharmacological kev txiav txim

Thaum nws nkag mus rau txoj hnyuv hauv plab, lub ntsiav tshuaj lossis lub pliav tshuaj plua plav maj mam yaj nrog kev tso tawm thiab tom qab kev nqus ntawm cov khoom nquag los ntawm phab ntsa ntawm txoj hnyuv. Los ntawm cov qog ua kua rau lub plab, fluvastatin nkag mus rau hauv cov hlab ntshav, qhov twg nws tsim covalent khi nrog plasma protein (qhov feem pua ​​ntawm khi yog tshaj 97%), uas tom qab ntawd nqa tawm thoob plaws lub cev. Fluvastatin nquag ua haujlwm thaum nws nkag mus rau hauv tib neeg lub siab: biosynthesis ntawm qis lipoproteins (LDL) thiab qis heev lipoproteins (VLDL) yog qhov tshuaj tiv thaiv. Qhov kev txo qis hauv qib ntawm LDL thiab LDL pab nce qhov kev nkag siab zoo ntawm cov receptors rau cov lipoproteins no thiab, vim li ntawd, lawv cov kev coj los ntawm hepatocytes nrog cov metabolism tom qab ua kom zoo dua.

Tsis tas li ntawd, cov tshuaj nquag ntawm cov ntsiav tshuaj ua raws li inhibitor ntawm apoliprotein B thiab TG, uas ua haujlwm thauj mus los rau cov roj "phem". Tawm tsam keeb kwm yav dhau los ntawm qhov txo qis hauv LDL thiab VLDL, qhov nce ntawm qhov siab ntawm lipoproteins (HDL) tau sau tseg. Nws tau sau tseg: qhov qis qis ntawm cov HDL rau lub sijhawm thaum pib xyaum ua, kho qhov siab ntau dua HDL nyob hauv nruab nrab ntawm cov kev kho mob. Cov kwv yees tseem ceeb ntawm cov teeb meem no: hauv cov neeg mob uas muaj HDL tsawg nyob rau hauv nruab nrab ntawm chav kawm muaj qhov nce ntawm "cov roj (cholesterol) tseem ceeb" txog 7%, thiab hauv cov neeg mob uas muaj HDL ib txwm - los ntawm 14%. Qhov tshwm sim ntawm cov txheej txheem biochemical saum toj no yog ib qho kev txo qis hauv LDL, VLDL, apoliproteins B thiab TG hauv tib neeg ntshav.

Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv lub cev raug pom ib teev tom qab siv tshuaj. Kev noj tsis cuam tshuam rau qhov nqus zaum kawg ntawm cov tshuaj, tab sis tuaj yeem ua rau qeeb txheej txheem nqus. Txawm li cas los xij, kev noj ntau dhau ntawm cov zaub mov muaj roj ua ntej noj ib ntsiav tshuaj lossis tshuaj ntsiav tuaj yeem ua rau ntau qhov muaj zog ntau hauv qhov kev xav ntawm cov tshuaj nquag hauv cov ntshav ntshav. Kev tshem tawm ib nrab-lub neej ua kom txog 9 teev nyob ntawm ib koob tshuaj ib zaug.

Cov txiaj ntsig kho tau pom tshwm sim tau pom ob lub lis piam tom qab pib siv tshuaj. Qhov siab tshaj plaws kho tau zoo yog pom tom qab plaub lub lis piam los ntawm thawj koob tshuaj.

Nws yog cov tshuaj tiv thaiv hauv lub siab thiab tawm thaum lub cev ntawm kev tso quav (dhau 90%) thiab dhau los ntawm cov kab mob txeeb zis (nce txog 10%). Cov nyhuv zuj zus (txuam nrog) yog qhov tsawg kawg lossis tsis tuaj kiag li. Kev nyab xeeb rau kev noj qab haus huv los sib xyaw ua ke muaj tshwm sim nrog kev kho mob siab dua ib xyoos.

Tsuas tshuaj thiab tswj hwm

Tsis hais txog lub sijhawm noj mov, fluvastatin yog siv ib hnub ib zaug hauv kev noj 80 mg lossis ib zaug lossis ob zaug ib hnub hauv qhov ntau npaum ntawm 20 lossis 40 mg. Lub sijhawm ntawm kev siv tshuaj tsis cuam tshuam rau kev nqus, tab sis feem ntau ntawm cov kws kho mob tshwj xeeb pom zoo rau thaum sawv ntxov tam sim tom qab yaim. Muab cov txiaj ntsig me me ntawm fluvastatin nyob rau hauv kev sib piv nrog cov tshuaj sib piv ntawm cov tiam tom ntej ntawm statins, nyob rau hauv feem ntau ntawm cov kis nws raug nquahu kom siv cov tshuaj nyob rau hauv ib koob tshuaj txhua hnub 80 mg. Txo qhov txo qis yog nqa tawm tsuas yog tias qhov kev txiav txim siab ntawm lipids tshaj li tus qauv los ntawm tsawg dua 15% thiab tsis zoo li ua kom cov ntshav plasma ntau. Hauv qhov no, pib nrog kev noj tshuaj 40 mg ib hnub twg, muab faib ua ob zaug: 20 mg thaum sawv ntxov thiab yav tsaus ntuj.

Thaum lub sijhawm kho mob nrog fluvastatin, nws raug nquahu kom tswj cov ntsiab lus ntawm lipids hauv cov ntshav ntshav kom thiaj li kho tau cov tshuaj ntau ntau yog tias tsim nyog. Kev soj ntsuam tau nqa tawm ib zaug hauv rau lub hlis, yog tias tsis muaj qhov tshwj xeeb ua ntej rau kev kawm ntau zaus. Qhov yuav tsum tau ua ua ntej yog qhov kev tsis txaus siab ntawm tus neeg mob txog nws tus mob.

Yam tsawg kawg nkaus kho chav: 12 hlis. Thaum noj tshuaj rau 30 lub hlis nyob rau hauv kev siv tshuaj txhua hnub ntawm 80 mg raws li kev tshawb fawb, qhov muaj tshwm sim ntawm txoj hlab ntshav atherosclerosis txo qis. Yog li, qhov zoo ntawm lub sijhawm ua kom zoo ntawm kev kho mob 36 lub hlis tau ua haujlwm tiav. Nyob rau hauv lub neej yav tom ntej, nws raug nquahu kom siv cov tshuaj rau 12 lub hlis raws li prophylactic. Yam tiv thaiv yam tsawg kawg nkaus: plaub lub lis piam.

Phiv thiab haus tshaj

Qhov yuav tsum tau cuam tshuam los ntawm kev kho vim muaj kev phiv tsis tshaj 1%. Cov tshuaj zoo rau. Qee qhov tsis tshua muaj tshwm sim, nws tuaj yeem sau tseg: cov tsos mob ntawm tus mob ntsws, mob taub hau, kiv taub hau, xeev siab, tsis muaj tsos mob. Kev tshem tawm yeeb tshuaj yog pom zoo thaum tswj cov xwm txheej no ntau dua ib lub lim tiam. Thaum raug yuam tshem tawm, nws yog qhov yuav tsum tau so tsawg kawg ob zaug hauv ib lub lim tiam thiab tom qab ntawd muab cov tshuaj analogues los ntawm cov pab pawg ntawm statins: lovastatin, atorvastatin lossis lwm yam tshuaj.

Cov xwm txheej phom sij rau tib neeg lub neej thiab kev noj qab haus huv thaum noj cov koob tshuaj loj tsis pom. Kev tsis xis nyob hauv txoj hnyuv thiab cov tsos mob dyspeptic yuav pom. Hauv cov ntshav ntshav, cov ntshav siab yuav hloov pauv, uas txo qis nrog kev txo qis hauv lub sijhawm lossis tsis kam siv tshuaj.

Cov Nta Tseem Ceeb

• Fluvastatin tam sim no tsuas yog tib leeg reductase inhibitor, kev sib xyaw ua ke tau tso cai nrog tshuaj ntawm cov pab pawg fibrate. Qhov no yog vim qhov txiaj ntsig me ntawm statin ntawm lub cev.
• Fluvastatin tau dhau los ua ntau lub chaw kuaj thiab chaw kuaj mob, vim tias cov haujlwm tau ua tiav tau raug pov thawj.
• Tus nqi ntawm "Fluvastatin", raws li txoj cai, yog me ntsis qis dua rau cov tshuaj ntawm cov cim niaj hnub no.

Kev txheeb xyuas txog "fluvastatin"

Alexander, 37 xyoo

Tus kws kho mob endocrinologist uas tau mus kawm kuv kho cov tshuaj fluvastatin thaum lub ntsiab ntawm cov triglycerides thiab cov roj (cholesterol) hnyav dhau heev lawm. Kev noj zaub mov hyperlipidemic tau ua ke pom zoo. Thawj 3 asthiv Kuv tsis tuaj yeem pom tias muaj txiaj ntsig tseem ceeb. Thaum xaus ntawm lub asthiv 4, ob hnub ua ntej txoj kev taug kev mus rau kev kuaj mob, nws tau sau tseg txog kev txhim kho hauv lub suab nrov ntawm lub cev - nws tau txuas nrog qhov no nrog kev noj zaub mov noj tshuaj. Lawv tau kuaj pom tias kev txo qis lipid yog 11%, thiab triglycerides - zoo li 8% (Kuv tsis nco qab tam sim no). Yog li ntawd, Kuv txiav txim siab ua qhov kev sim kuv tus kheej yam tsis tau ceeb toom rau tus kws kho mob. Tso tseg kev noj haus - nws yeej tsis tshoov kuv kom ua tiav zoo. Rau ob lub hlis Kuv tsis tau ua raws li cov khoom noj xav tau, tab sis raws li cov lus qhia Kuv siv Fluvastatin tsiav tshuaj. Kuv tau txais peb kilo yam tsis muaj qhov cuam tshuam rau lub suab dav dav. Thaum kawg ntawm lub hlis thib peb txij thaum pib ntawm txoj kev kho mob, nws tau kuaj dua - kev txhim kho ntxiv tau sau tseg (qhov tsis haum ntawm lipids thiab triglycerides tsawg los ntawm ntau feem pua). Yog li, Kuv xav tias cov tshuaj yeej muaj txiaj ntsig zoo. Tab sis los ua ke nrog kev noj haus, nws yog qhov tsim nyog, txij li phaus ntxiv - rau dab tsi. Kuv tau haus Fluvastatin tau yuav luag ib xyoo tam sim no. Kuv muab tso rau hauv zoo-tau tsib mus rau cov tshuaj.

Nikita Stolbovsky, 52 xyoo, tus kws kho keeb, tus kws noj zaub mov noj haus

Nyob zoo Ua ntej tshaj plaws, kuv qhov kev tshuaj xyuas ntawm Fluvastatin yuav muaj txiaj ntsig zoo rau cov kws tshaj lij, tab sis yog tias nws los ntawm tes kuv tsuas yog kev zoo siab. Nws yog hais txog kuv xyaum. Kev teem caij pib ntawm atorvastatin, raws li cov tshuaj uas tsim nyog tshaj los txo LDL cov tshuaj muaj peev xwm, ua rau muaj kev phiv rau hauv tus neeg mob nrog kev xoom xoos ntawm myositis. Nws tuaj ua tiav txoj kev tshem tawm sai thiab muaj kev ntsuas kho vaj tse sai. Tom qab ib hlis, kev kho mob yuav tsum tau txuas ntxiv, raws li qhov LDL qhov kev cia siab ntau ntxiv. Atorvastatin tau hloov los ntawm lovastatin, yog cov tshuaj ua kom zoo tshaj plaws hauv qhov kev coj ua no. Qhov tshwm sim yog qhov ua tsis tau zoo kho lub cev. Nws pib mus nrhiav cov kev xaiv rau cov kev txuag txoj kev kho. Nws nres qhov xim ntawm "Fluvastatin" nrog kev nce ntxiv hauv txoj kev kho ntawm "Fenofibrate". Fluvastatin tau muab tshuaj rau 20 mg ob zaug ib hnub. Ib hlis tom qab, tau txo qis hauv LDL cov ntsiab lus zoo. Tab sis, tsuas yog qee zaum, Kuv xa tus neeg mob txhua hli rau kev kuaj mob.

Fluvastatin thaum cev xeeb tub

Nws yog txwv tsis pub sau ntawv rau cov tshuaj Fluvastatin thaum lub sijhawm cev xeeb tub los ntawm tus poj niam ntawm tus menyuam. Raws li cov kev tshawb fawb tau tshawb pom, nws tau paub tias kev noj cov tshuaj statins cuam tshuam ntau txoj kev loj hlob ntawm tus me nyuam hauv plab thiab ua rau muaj cov kab mob txawv txav uas yug hauv lub cev.

Yog tias hom tshuaj tiv thaiv no ua rau cov tshuaj lom cov roj hauv lub cev ntawm tus poj niam cev xeeb tub, tom qab ntawd txhua lub cev ntawm cov menyuam yaus ntab xav tias qhov muaj cov cholesterol. Kev tsim cov khoom tsis zoo hauv lub cev (cov roj (cholesterol) hauv cov hlwb ua rau muaj kev txawv txav thaum yug.

Cov poj niam uas muaj lub sijhawm los muab menyuam thaum muaj hnub nyoog yog cov tshuaj fluvastatin, tsuas muaj tib lub sijhawm xwb, kev siv tshuaj tiv thaiv thaum lub sijhawm kho tshuaj nrog rau statins.

Yog tias tus poj niam xeeb menyuam, nws yog qhov yuav tsum tau tsum tsis txhob noj cov tshuaj, lossis, yog tias nws tsis tuaj yeem tsis lees noj tshuaj, muaj cov lus nug ntawm kev ncua lub cev xeeb tub.

Nyob rau lub sijhawm thaum tus pojniam tabtom pub mis rau menyuam noj, fluvastatin yuav tsum tsis txhob raug ntxiv.

Statins muaj peev xwm txeem tau rau hauv niam cov kua mis, nrog lub siab zoo dua li ntawm sib xyaw cov ntshav muaj ntshav.

Cov Hypersensitivity Syndrome thiab Fluvastatin

Kev tshwm sim ntawm kev mob siab ntsws hauv tus neeg mob tau qhia tawm hauv cov tsos mob thiab pathologies li nram no:

• Kev loj hlob ntawm anaphylactic kev poob siab,
• Quincke o,
• Mob ntsws mob hlwb.

Lub plab ua teb rau qhov nqus ntawm statins hauv koj lub cev:

• Cov txheej txheem mob hauv cov kab mob hauv lub siab ntawm tus kab mob siab ntawm ntau yam kab mob,
• Cell tuag necrosis,
• Nquag ntuav tawm ntawm lub cev,
• Cov txheej txheem mob tshwm sim hauv cov hlwb ntawm tus kab mob siab txiav tawm ntawm caj pas,
• Qhov mob daj ntseg ntawm cholecystitis etiology,
• Kev tiv thaiv kab mob hauv lub plab zom mov anorexia,
• Hepatoma pathology,
• Tus kab mob siab mob ntsws.

Tus kab mob siab mob ntsws

Cov tshuaj tiv thaiv ntawm daim tawv nqaij thiab yug me nyuam muaj zog los noj fluvastatin

Daim tawv nqaij yog qhov pib ua ntej rau cov kev tsis zoo los ntawm cov tshuaj ntawm cov tshuaj fluvastatin.

Kev qhia ntawm daim tawv nqaij coj lawv mus rau lub xeev no:

• Alopecia hauv qee qhov ntawm daim tawv nqaij,
• Pigmentation tshwm rau ntawm daim tawv nqaij,
• Cov tawv nqaij qhuav tsim,
• Thaum kuaj pom cov hnoos qeev qhuav,
• Kev kawm txog pathology muaj mob pruritus.

Qhov tshwm sim tsis zoo ntawm lub cev mus rau kev noj cov tshuaj statins kuj tseem kuaj tau hauv qhov chaw mos.

Thiab qhov tshuaj tiv thaiv no nthuav qhia nws tus kheej hauv kev ua txhaum cai ntawm tus qau:

• Tseem ceeb txo libido hauv poj niam lub cev,
• Muaj cov cim qhia ntawm impotence nyob rau hauv cov txiv neej,
• Gynecomastia pathology,
• Kev tsis sib haum xeeb hauv kev ua kom sib txawv tau tshwm sim
• Cov kab menyuam ua kom tsis taus menyuam.

Ntxiv nrog rau qhov kev mob tsis zoo ntawm lub cev qhov tshwm sim los noj cov tshuaj statins rau ntawm lub cev, cataracts ntawm ocular hloov thiab ua kom muaj qhov muag tsis meej hauv lub qhov muag teeb.

Thaum noj Fluvastatin, kuj tseem muaj qhov nce ntxiv hauv kev ua haujlwm ntawm tag nrho endocrine system thiab cov thyroid caj pas.

Xaus

Cov tshuaj Fluvastatin yog cov tshuaj zoo tshaj plaws rau cov plab hnyuv siab raum ntawm tag nrho lub cev, uas maj mam txo qib lipoproteins hauv cov ntshav, thiab nws cov tshuaj siv ua ke nrog cov tshuaj fibrate ua rau cov kev kho tsis muaj txiaj ntsig yam tsis ua rau muaj kev phiv ntau.

Tsis tas li, cov tshuaj muaj tsawg kawg nkaus ntawm contraindications rau siv.

Kev Ntsuam Xyuas Rau Neeg Mob

Sergey, 49 xyoo, lub nroog ntawm Peter: Kuv raug kho los ntawm tus kws kho mob-endocrinologist noj tshuaj Fluvastatin, tom qab kev kuaj mob pom tias muaj LDL siab dhau. Ntxiv nrog rau kev noj tshuaj, kev noj tshuaj tiv thaiv kab mob ntshav siab tau muab tshuaj tua. Tom qab 21 hnub, Kuv dhau qhov kev ntsuam xyuas rau cov ntawv pov thawj thiab pom ib qho txo ​​10.0% ntawm lipids. Kuv tsis tau ua raws li kev noj haus nruj, vim kev noj zaub mov zoo li no ua rau kuv pheej tshaib plab thiab npau taws.Txawm hais tias tsis muaj adhering rau kev noj haus nruj, fluvastatin qhia nws cov nyhuv kho. Tsawg dua qhov LDL tseem tshwm sim.

Eugenia, 56 xyoo, lub nroog ntawm Saratov: Ua ntej noj Fluvastatin, Kuv txo qis roj cholesterol nrog zaub mov noj thiab Atorvastatin. Kev phiv los ntawm cov tshuaj statin no tau muaj kev cuam tshuam zoo heev ntawm kev zom zaub mov thiab hauv cov leeg hlwb. Rau kuv, tus kws kho mob hloov cov tshuaj nrog fluvastatin thiab, txhawm rau txhim kho nws cov nyhuv, kws kho kev sib txig sib luag ntawm fibrates. Kuv tau noj ob qho tshuaj no tau 20 hnub, txog thaum kuv hnov ​​qhov tsis zoo, thiab kev kuaj mob tau pom tias cov ntshav lipids tsawg dua.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Tus nquag ua hauj lwm yog sodium fluvastatin. Txuas ntxiv, tuaj yeem siv:

• magnesium stearate,
• sodium bicarbonate,
• talcum hmoov
• pob kws nplej siab
• gelatin thiab lwm yam.

Cov tshuaj muaj nyob rau hauv daim ntawv uas muaj xim daj los yog dawb ntsiav tshuaj thiab tsiav tshuaj. Cov tom kawg muaj cov hmoov zoo hygroscopic. Cov khoom yog soluble heev hauv dej. Siv rau kev tswj hwm qhov ncauj.

Kws Tshuaj

Tom qab nkag mus rau lub lumen ntawm txoj hnyuv plab hnyuv (lub plab zom mov), cov tshuaj ntsiav tau maj mam tawg, tom qab ntawd los ntawm kev tshem tawm cov tshuaj nquag. Nws yog nqus tau los ntawm cov phab ntsa hauv cov hnyuv, nkag mus rau cov roj ntsha feem ntau. Qhov siab tshaj plaws ntawm fluvastatin raug pom 60 feeb tom qab siv tshuaj. Khoom noj khoom haus tsis cuam tshuam rau kev nqus, tab sis pab qeeb nqus. Ib nrab-lub neej ntawm cov tshuaj yog 9 teev.

Ib qhov txiaj ntsig kho tau zoo tau ua tiav ob lub lis piam tom qab pib ntawm chav kawm. Qhov siab tshaj plaws raug pom tau tom qab 4 lub lim tiam ntawm kev siv tas li. Nws ua rau nrog quav ua quav (kwv yees 90%) thiab zis (10%). Cov ntawv xav tau (siv zuj zus) yog qhov tsawg.

Cov lus qhia rau kev siv

Raws li cov lus qhia rau kev siv, cov tshuaj yog tso cai rau coj los ntawm cov neeg laus thiab cov menyuam yaus uas muaj hnub nyoog txog 9 xyoo pib. Qhov kev zam tau yog cov ntxhais ua ntej pib kev coj khaub ncaws, txij li kev tshawb nrhiav txog cov nyhuv ntawm Fluvastatin rau cov poj niam txiv neej cov tshuaj hormones tsis tau ua.

Qhov pom zoo kom noj tshuaj txhua hnub yog 20-40 mg. Nws yog ib qho tsim nyog yuav tau noj cov tshuaj nyob rau yav tsaus ntuj, txij li feem ntau ntawm cov cholesterol yog ua thaum hmo ntuj. Qhov siab tshaj plaws kho tau tshwm sim tau 24 hnub tom qab pib ua haujlwm. Thaum lub sijhawm kho tag nrho, nws yog ib qhov tsim nyog los soj qab theem ntawm cov lipoproteins uas muaj ntau kom ua tau raws caij cov tshuaj kho kom haum.

• 1 tshuaj ntsiav (40 mg) lossis 1 ntsiav tshuaj (80 mg) - ib hnub ib zaug,
• 2 tsiav tshuaj ib hnub - ntawm kev pom zoo ntawm tus kws kho mob tuaj koom.

Thawj qhov muab tshuaj rau menyuam yaus yog 20 mg. Nrog rau kev txhim kho kev mob tshwm sim, chav kawm yuav tsum muaj kev cuam tshuam, tab sis tsuas yog tias muaj cov tsos mob mus ntev tsawg kawg ib lub lis piam. Fluvastatin analogs tuaj yeem pib noj tsis tau ua ntej ob lub lis piam tom qab tsis ua hauj lwm ntawm kev kho nrog tus neeg sawv cev qub.

Siv thaum lub caij nyoog ris tus menyuam

Thoob plaws sijhawm kev siv cev xeeb tub, noj cov tshuaj statin yog raug txwv tsis pub muaj. Cov kws kho mob tawm tswv yim hais tias cov tshuaj ua kom lub zog ua kom zoo tsis txaus tsuas yog ua ke ntawm cov cholesterol, tab sis kuj muaj cov tshuaj muaj txiaj ntsig zoo uas cov menyuam hauv plab xav tau kev txhim kho thiab kev loj hlob tsis tu ncua. Tsis muaj kev tshawb nrhiav tau ua qhov haujlwm no.

Yog tias kev loj hlob ntawm cev xeeb tub tau tshwm sim thaum lub sijhawm noj tshuaj, tom qab ntawd paub meej tias, chav kawm yuav tsum nres tam sim ntawd. Tus poj niam yuav raug tshuaj ntxiv rau lwm yam tshuaj pom zoo. Kev kho mob nrog fluvastatin kuj tsis tau nqa tawm thaum pub niam mis. Cov tshuaj cuam tshuam mus rau hauv cov mis thiab yuav tsim kev puas tsuaj rau tus menyuam mos lub cev.
Hauv thaum yau

Txog hnub nyoog txog 9 xyoos, cov tshuaj txwv tsis pub ua tiav. Tom qab ntawd, ntau npaum li cas tau muab suav raws li cov lus pom zoo los ntawm tus kws kho mob. Fluvastatin yog kho rau cov tub thiab ntxhais tom qab qhov pib coj khaub ncaws ua ib feem ntawm kev kho mob nyuaj. Kev ntsuas - nce cov roj cholesterol, apoliprotein B, heterozygous tsev neeg hypercholesterolemia. Ib qho ntxiv, kev noj haus yog kev pom zoo.

Yeeb tshuaj sib cuam tshuam

Thaum sau daim ntawv noj tshuaj, nws yog ib qho tsim nyog yuav tsum xav txog qhov sib xyaw ntawm cov tshuaj nquag.

Yog tias tsim nyog, cov tshuaj tuaj yeem hloov nrog analogues. Hauv qhov no, tuaj yeem siv:

• Pravastatin. Cov tshuaj phiv tshuaj yog sodium pravastatin. Cov cuab yeej thaiv kev tsim cov roj (cholesterol) los ntawm qhov txo cov haujlwm ntawm HMG coenzyme A-reductase. Nws yog siv raws li kev kho mob nyuaj, nrog rau kev tiv thaiv thawj lossis theem nrab.
• Leskol. Tus nquag ua hauj lwm yog fluvastatin. Nws zwm rau pab pawg ntawm cov tshuaj tiv thaiv hypolidimic nrog cov nyhuv hypocholesterolemic. Nws yog cov tshuaj tiv thaiv HMG-CoA reductase, txo cov roj synthesis. Ua ntej pib kho, nws yog ib qhov tsim nyog yuav tsum kuaj xyuas daim siab.
• Lovastatin. 1 ntsiav tshuaj ntawm cov khoom yuav muaj 20/40 mg ntawm cov tshuaj nquag, uas yog lovastatin. Cov tshuaj muaj cov lipid-txo cov nyhuv. Nws tsis yog siv rau thaum tseem yau thiab thaum tiav hluas, muaj qhov paub zoo ntxiv. Cov kev mob tshwm sim muaj ntau. Siv lub cuab yeej thaum yav tsaus ntuj thaum noj hmo.
• Leskol Forte. Cov tshuaj tseem ceeb yog fluvastatin sodium ntsev. Cov tshuaj yog npaj rau txhawm rau tsim cov tshuaj HMG-CoA reductase thiab txo cov roj cholesterol tsim tawm. Cov txiaj ntsig ntawm kev kho mob nrog tshuaj tau sau tseg nyob rau thaum xaus ntawm lub lim tiam thib ob.

Kuj tseem muaj cov cim tshiab:

• Atorvastatin. Cov tshuaj muaj zog yog atorvastatin calcium trihydrate. Cov cuab yeej muaj cov nyhuv hypocholesterolemic.
• Simvastatin. Lub ntsiab tivthaiv yog simvastatin. Cov tshuaj tiv thaiv hypolipidemic. Tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj, txo qis hauv roj cholesterol thiab triglycerides yog sau tseg. Lub cuab yeej tuaj yeem ua rau ntau qhov kev phiv. Nws tsis yog cai rau cov neeg mob uas muaj hnub nyoog tsis txog 18 xyoo, thaum cev xeeb tub thiab lactation.
• Rosuvastine. Lub ntsiab tshuaj kho kom zoo yog cov tshuaj rosuvastatin. Hais txog cov tshuaj lipid-txo qis. Nws tsis yog yuav tsum tau coj nrog kev noj mov, vim tias cov zaub mov txo tus nqi ntawm kev nqus ntawm cov khoom. Contraindication yog lub hnub nyoog ntawm tus neeg mob. Qhov cuab yeej tsis siv yog hais tias ib tus neeg muaj hnub nyoog qis dua 18 xyoo lossis yog tias nws twb hla lub cim 65 xyoo.

Kev tsim cov tshuaj tshiab ib zaug ib hnub. Qhov no yog txaus los muab cov theem tsim nyog ntawm kev xav txog ntawm cov tshuaj nquag hauv cov ntshav ntshav. Ib qho sib txawv ntxiv ntawm cov analogues yav dhau los yog qhov uas tsawg dua ntawm cov lipoproteins uas tsis muaj neeg coob thiab qhov nce siab hauv lipoproteins.

Kev teb rau kev siv cov tshuaj muaj ntau. Ntau ntawm lawv tham txog qhov ua tau zoo ntawm cov tshuaj. Tab sis cov chav kawm ntawm kev siv tshuaj statin yog lub sijhawm ntev thiab khi tus neeg mob kom ua raws li kev noj haus tshwj xeeb.

Kev Sau ua ke, daim foos tso tawm

Fluvastatin muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated. Lawv muaj xim daj, xim, puag ncig nrog "LE", "NVR".

Ib ntsiav tshuaj Leskol Forte muaj:

• 80 mg fluvastatin (cov tshuaj muaj zog)
• cellulose
• hypromellose
• hydroxypropyl cellulose,
• poov tshuaj bicarbonate,
• povidone
• magnesium stearate,
• titanium dioxide (E 171)
• macrogol
• daj hlau oxide (E 172).

Leskol Forte: qhov taw qhia rau kev siv

Fluvastatin tau sau tseg rau cov neeg mob uas tsis tau txais kev pabcuam kev noj zaub mov, nrog:

• thawj hypercholesterolemia,
• tov dyslipidemia,
• atherosclerosis mob rau cov neeg mob uas muaj mob rau cov hlab ntshav ntawm cov hlab ntshav me, hypercholesterolemia me.

Kev siv cov tshuaj hauv cov neeg mob uas muaj mob plawv tuaj yeem tso cai rau koj:

• txo tus naj npawb ntawm kev tuag tam sim ntawd los ntawm kab mob plawv,
• txo txoj kev pheej hmoo ntawm kev tsim myocardial infarction los ntawm 31%,
• txo qis tus naj npawb ntawm cov kev pab cuam phais (revascularization, bypass phais).

Cov txiaj ntsig zoo ntawm kev noj fluvastatin hauv cov neeg mob ntshav qab zib mellitus, nrog rau ntau qhov txhab ntawm cov hlab ntshav ntawm cov hlab ntsha, tshwj xeeb tshaj yog pom.

Cov lus qhia rau fluvastatin muab cov ntaub ntawv los ntawm kev tshawb fawb loj. Nws tau qhia tias hauv cov neeg mob mob cov hlab ntshav liab, kev tswj hwm ntawm Leskol forte rau 2,5 xyoo (koob 40 mg), qhov ua tau zoo ntawm cov mob txhab ntshav atherosclerosis tau nres.

Leskol yog ib qho ntawm ob peb cov statins uas tuaj yeem raug kho rau cov menyuam yaus muaj kabmob hypercholesterolemia. Nws tuaj yeem nqa los ntawm 9 xyoos. Nws yog pov thawj tias noj fluvastatin tsis cuam tshuam nrog kev loj hlob, kev loj hlob, kev nkauj nraug.

Txoj kev ntawm daim ntawv thov, ntau npaum li cas

Cov lus qhia tseem ceeb uas tus neeg mob yuav tsum paub txog kev noj fluvastatin:

• ua raws cov roj cov zaub mov txo qis thaum lub sijhawm kho mob. Txwv tsis pub, cov tshuaj yuav tsis zoo,
• Leskol Forte yuav tsum noj 1 zaug / hnub, tag nrho, tsis hais zaub mov, sijhawm nruab hnub,
• haus ib ntsiav tshuaj nrog ib khob dej,
• siv sij hawm los noj cov tshuaj, lo rau nws thoob plaws hauv chav kawm,
• yog tias koj yuam kev noj tshuaj, kho nws sai li sai tau. Qhia tias kom txog rau tom qab 12 teev ntau dua. Koj tsis muaj sijhawm? Noj cov tshuaj ntxiv rau lub sijhawm, tsis tas yuav nce qhov koob tshuaj,
• Tsis txhob hnov ​​qab pub nyiaj ntshav tsis tu ncua los tswj cov cholesterol. Thawj thawj lub sijhawm lawv siv kev ntsuas yog feem ntau, tom qab ntawd - raws li
• tso quav cawv.

Qhov pom zoo koob tshuaj rau cov neeg laus yog 80 mg. Nrog rau daim ntawv me me ntawm cov muaj keeb hypercholesterolemia, cov menyuam yaus noj 20 mg ntawm fluvastatin txhua hnub, thiab hauv hnyav - 80 mg.

Fluvastatin txawv li cas ntawm lwm cov statins?

Ib feem tseem ceeb ntawm statins yog txaws tawm ntawm lub cev los ntawm lub raum. Yog li ntawd, lawv cov kab mob yuav tsum tau kev coj ceev faj. Leskol Forte yog kev xyaum ua haujlwm tsis dhau los ntawm lub raum (tsuas yog 2%), nws tuaj yeem yog cov tshuaj rau cov neeg mob uas muaj teeb meem nephrological.

Qhov tseem ceeb thib ob ntawm fluvastatin thiab analogues yog tias nws muaj kev nyab xeeb thaum noj ua ke nrog vitamin B3, colestyramine, fibrates, itraconazole, erythromycin, digoxin, amlodipine, colchicine.

Ua tsaug rau qhov kev nqis tes ua ntev, Leskol tuaj yeem siv thaum lub sijhawm nruab hnub. Qhov no tsis cuam tshuam cov nyhuv ntawm cov tshuaj.

Kuv raug ua haujlwm rau Leskol Forte. Tam sim no yuav tsum tau muab nws rau lub neej?

Cov neeg feem coob yuav raug noj tshuaj tiv thaiv ntshav kom tsawg. Qhov no yog vim lub peculiarity ntawm mechanism ntawm kev ua. Cov nyhuv ntawm kev siv statins yog tsuas yog thaum noj lawv. Leskol Forte yog cov tshuaj kim heev, tab sis koj tuaj yeem ib txwm nug tus kws kho mob kom xaiv ib qho nyiaj txiag siv.

Cov kws kho mob cov tswv yim ntawm fluvastatin

Cov tshuaj muaj cov roj uas txhaws cov nyhuv. Atorvastatin, rosuvastatin muaj zog ntau dua li nws. Leskol Forte yuav pab tau zoo rau cov neeg mob uas muaj teeb meem lub raum, txawm hais tias rosuvastatin kuj tsis yog qhov tsis zoo rau lawv.

Kev sib tw tseem ceeb ntawm fluvastatin yog lub peev xwm los sau nws rau menyuam yaus txij thaum 9 xyoo. Tag nrho lwm yam tshuaj yog ob qho tib si sib kis los yog qhia rau hnub nyoog laus dua.

Cov ntaub ntawv npaj los ntawm tus sau phau ntawv ntawm qhov project
raws li txoj cai kho ntaub ntawv ntawm lub xaib.