Simvastatin ntsiav tshuaj: dab tsi yog lawv tau tsim rau thiab dab tsi yog lawv rau?

Simvastatin yog tshuaj noj nrog lipid-txo cov khoom. Tau txais cov tshuaj uas siv cov tshuaj lom neeg los ntawm cov khoom lag luam ntawm cov enzymatic metabolism ntawm Aspergillus terreus.

Tus txheej txheem tshuaj lom neeg ntawm cov tshuaj yog ib hom hauv lub zog ntawm lactone. Los ntawm kev hloov biochemical, cov roj (synthesis) tshwm sim. Kev siv cov tshuaj tiv thaiv cov kev txuam nrog cov tshuaj lom lipids ntau hauv lub cev.

Cov roj ntsha ntawm cov tshuaj yog cov uas ua rau cov ntshav txo qis ntau ntawm triglycerides, atherogenic feem ntawm lipoproteins, ntxiv rau qib cov roj (cholesterol) tag nrho. Kev tsuj tawm ntawm kev sib txuas ntawm cov atherogenic lipids tshwm sim vim yog kev tsuj tawm ntawm kev tsim cov cholesterol nyob rau hauv hepatocytes thiab kev nce ntawm cov txheej txheem receptor rau LDL rau ntawm cov cell ua, uas ua rau kev ua kom muaj zog thiab siv LDL.

Nws tseem nce qib ntawm cov lipoproteins ntau ntom, txo qhov feem ntawm atherogenic lipids rau antiatherogenic thiab theem ntawm cov roj cholesterol dawb rau antiatherogenic feem.

Raws li kev soj ntsuam hauv chav soj ntsuam, cov tshuaj tsis ua rau muaj kev sib txuam ntawm tes. Tus nqi ntawm qhov pib ntawm txoj kev kho kom zoo Cov hnub pib ntawm qhov tshwm sim ntawm cov nyhuv yog 12-14 hnub, qhov siab tshaj plaws kho tau tshwm sim ib hlis tom qab pib siv. Cov nyhuv yog mus tas li nrog lub sijhawm ntev ntawm kev kho mob. Yog tias koj tsum tsis noj cov tshuaj, theem ntawm cov roj endogenous rov qab mus rau nws qib qub.

Cov tshuaj muaj pes tsawg leeg yog sawv cev los ntawm cov tshuaj nquag Simvastatin thiab cov ntu pabcuam.

Cov khoom muaj qhov siab nqus thiab tsawg bioavailability. Txhawm rau cov ntshav, khi rau albumin. Daim ntawv ua haujlwm tseem ceeb ntawm cov tshuaj yog synthesized los ntawm cov kev hloov pauv biochemical.

Simvastatin metabolism tshwm sim hauv hepatocytes. Nws muaj cov nyhuv ntawm "kev hla mus los" los ntawm lub siab ua haujlwm. Kev muab pov tseg tshwm sim los ntawm cov hnyuv (mus txog 60%) hauv hom kev siv lub cev tsis ua haujlwm. Ib feem me me ntawm cov tshuaj tau muab pov tseg los ntawm ob lub raum hauv ib daim ntawv uas tsis ua haujlwm.

Muaj pes tsawg leeg thiab noj ntau npaum

Simvastatin (INN los ntawm radar - simvastatin) yog cov tshuaj nquag muaj nyob hauv ntau cov tshuaj lag luam tshuaj ntawm cov tuam txhab sib txawv thiab cov npe hauv cov npe sib txawv (Zentiva, Vertex, Northern Star thiab lwm tus, nyob ntawm lub teb chaws). Qhov sib xyaw ua ke rau cov neeg thib peb ntawm statins thiab yog ib qho khoom pov thawj lipid-txo qis.

Ntawm lub tsev muag tshuaj txee koj tuaj yeem nrhiav ib cov tshuaj uas muaj lub npe uas zoo ib yam rau cov tshuaj nquag - Simvastatin. Daim ntawv ntawm tso tawm cov tshuaj yog ntsiav tshuaj, muaj biconvex puag ncig sawv, yog coated nrog pob tshab lossis cov xim ci xim. Nyob ntawm seb qhov mob siab ntawm cov tshuaj nquag, Simvastatin ntsiav tshuaj muaj nyob hauv ntau hom - 10 thiab 20 mg txhua.

Cov roj (cholesterol) hauv cov hlab ntshav ntawm tus neeg tsuas yog tshwm sim hauv cov duab protein. Cov tebchaw hu ua lipoproteins. Hauv lub cev muaj ntau hom kev lwg me no - siab, qis thiab tsis tshua ntom (HDL, LDL thiab VLDL, feem). Qhov tshwm sim tsis zoo ntawm cov roj (cholesterol) siab pib tshwm sim thaum nws tshwm sim hauv lipid metabolism. ntshiab kom zoo dua rau LDL, cov roj (cholesterol) tsis zoo.

Cov txiaj ntsig kho ntawm simvastatin tau tiav feem ntau los ntawm kev txo qhov feem me me ntawm lipoproteins (LDL). Los ntawm kev thaiv cov txheej txheem enzymatic ntawm HMG - Coenzyme A reductase, cov tshuaj uas tau kawm txo cov kev sib txuam ntawm cov rog hauv cov hlwb thiab ua rau cov chaw txais rau cov lipoproteins tsawg thiab tsawg heev (LDL thiab VLDL). Yog li, lub pathogenesis ntawm hypercholesterolemia yog pawg los ntawm ob lub tshuab ib zaug - cov roj cholesterol yog qhov tsis zoo pom los ntawm cov hlwb thiab muaj ntau nrawm dua tawm los ntawm cov hlab ntsha thiab lub cev tag nrho.

Tawm tsam cov keeb kwm yav dhau los ntawm qhov txo qis hauv cov teeb meem feem ntau ntawm cov rog, lipid tshuav nyiaj tau rov qab los thiab qhov kev xav ntawm cov kev tawm tsam, cov roj cholesterol siab, yog nce ntxiv. Raws li ntau qhov chaw, qhov nce hauv HDL tom qab cov chav kawm ntawm txoj kev kho yuav yog los ntawm 5 txog 14%. Simvastatin tsis tsuas yog txo qis cov cholesterol, tab sis kuj tseem muaj vasoconstrictor sivCov. Cov tshuaj no inhibits cov txheej txheem ntawm kev tsis ua haujlwm ntawm phab ntsa vascular, nce nws elasticity thiab lub suab vim cov nyhuv antioxidant.

Ib qho ntawm qhov theories ntawm kev txhim kho ntawm atherosclerosis yog mob. Lub ntsiab lus ntawm o yog ib qho yuav tsum yog ntawm ib qho kev ua kom pom tseeb atherosclerotic hauv endothelium. Simvastatin muaj cov txiaj ntsig tiv thaiv kab mob, thiaj li tiv thaiv endothelium los ntawm kev kho pob txuv, mob caws pliav thiab stenosis. Tus nab npawb ntawm cov kev tshawb fawb pom tau hais tias muaj kev tiv thaiv ntawm qhov endothelium yog tsim nyob rau ib hlis tom qab pib siv tshuaj.

Lub hom phiaj ntawm cov tshuaj yog nqa tawm tsuas yog raws li cov cim qhia nruj, xaiv cov koob tshuaj yog ib leeg. Pib noj feem ntau 10 mg thiab, raws li cov neeg mob thiab kws kho mob, muaj kev tiv thaiv zoo. Qhov tshuaj ntau ntau txhua hnub yog 80 mg. Nws yog tsim rau qhov mob nyhav ua kom hnyav. Rau cov neeg mob mob siab me lossis mob raum, qhov siab tshaj plaws yuav tsawg dua thiab yog 40 mg.

Kev ntsuas rau siv

Cov tshuaj Simvastatin tau sau tseg rau kev kho mob ntawm cov xwm txheej thiab kab mob:

Hypercholesterolemia IIA thiab IIB hom raws li kev faib tawm ntawm Fredrickson. Statins yog tau sau tseg yog tias kev hloov kho kev noj zaub mov, kev ua neej thiab lwm yam tsis raug tshuaj tsis tau coj cov kev kho mob uas xav tau. Lawv pab tiv thaiv cov roj ntshav siab tsis tu ncua ntawm qhov kev pheej hmoo ntawm kev txhim kho tus mob plawv tiv thaiv cov keeb kwm yav dhau los ntawm atherosclerosis ntawm cov hlab ntshav ntawm lub plawv thiab kev tsim cov quav hniav.
Lawv siv yog qhia nyob rau ntawm qhov tseem ceeb ntawm tsis tsuas cov roj cholesterol feem, tab sis kuj triglycerides. Ua tsaug rau cov txheej txheem ntawm kev ua ntawm Simvastatin, nws muaj peev xwm los txo qis qhov kev xav ntawm TG (triglycerides) hauv cov ntshav los ntawm yuav luag 25%.
Simvastatin tau sau tseg rau hauv ib txoj hauv kev saib xyuas kev kho mob rau kev tiv thaiv vascular thiab mob plawv - mob hlab ntsha tawg, plawv nres, atherosclerosis. Tawm tsam keeb kwm yav dhau los ntawm kev siv cov tshuaj no, cov qib roj cholesterol yog maj mam rov qab zoo li qub.

Txhua qhov kev npaj roj cov roj muaj cov cim qhia tshwj xeeb, daim ntawv teev cov kev mob tshwm sim thiab cov sib txuam sib kis, yog li ntawd lawv tuaj yeem tsuas yog kws kho mob sau rau hauv daim ntawv ntawm cov tshuaj hauv Latin.

Cov Yuav Tsum Muaj

Zoo li ib yam tshuaj twg, Simvastatin muaj ntau tus lej nruj kev tiv thaiv, uas nws yuav tsum tau caiv. Cov mob no suav nrog:

Lub caij nquag ntawm cov kab mob pathologies ntawm hepatobiliary system, nrog rau lub caij nyoog ntev, tsis pom kev nce siab ntawm hepatic transaminases ntawm cov keeb kwm tsis paub.
Myopathic kab mob. Vim yog myotoxicity, simvastatin tuaj yeem ua rau cov chav kawm ntawm cov leeg mob, ua rau rhabdomyolysis thiab lub raum tsis ua haujlwm tom qab nws.
Cov me nyuam lub hnub nyoog. Hauv kev xyaum ua me nyuam yaus, tsis muaj kev paub txog kev siv cov tshuaj no. Hauv kev tshawb fawb, tsis muaj ntaub ntawv qhia txog qhov muaj txiaj ntsig thiab kev nyab xeeb ntawm Simvastatin rau cov neeg mob hnub nyoog qis dua 18 xyoo.
Cev xeeb tub thiab pub niam mis - tsis muaj statin siv rau cov roj cholesterol thaum lub sijhawm no.

Nrog kev ceeb toom zoo, simvastatin tau sau tseg rau cov neeg uas quav cawv - kev sib raug zoo nrog cawv nyob rau hauv statins yog tsawg, thiab lub raum thiab hepatic tsis muaj peev xwm tsim tau sai heev.

Sab sij huam

Los ntawm cov plab hnyuv plab hnyuv plab zom mov tuaj yeem mob plab, ua haujlwm dyspeptic syndromes, xeev siab, ntuav, thiab tso quav. Kev siv cov tshuaj tuaj yeem cuam tshuam lub siab ua haujlwm - raws li cov lus qhia, nce ib ntus rau cov kab mob siab (ntshav hloov chaw) yog qhov ua tau.

Lub hauv nruab nrab thiab qhov siab ntawm lub paj hlwb tuaj yeem teb rau kev siv simvastatin nrog kev txhim kho ntawm kev mob siab ntsws astheno nrog kev mob hlwb ntawm cephalgia, qaug zog, qaug zog, hloov pauv mus pw, pw tsaug zog, thiab kiv taub hau. Cov kev mob tshwm sim ntau ntawm Simvastatin suav nrog cov leeg nqaij (qhov tsis txaus siab), qhov tsis zoo uas tsis hnov tsw, hloov pauv hloov.

Nrog tus neeg muaj lub siab nkag siab zoo rau cov tshuaj nquag lossis pabcuam ntawm cov tshuaj no, kev tawm tsam tuaj yeem loj tuaj. Muaj ntau ntau yam ntawm lawv qhov kev tshwm sim, tab sis raws li kev txheeb cais, urticaria, eosinophilia, kev ua xua, mob caj dab thiab mob polymyalgia ntawm rheumatoid genesis tuaj yeem txhim kho feem ntau.

Cov tawv nqaij ua pov thawj ntawm kev tshwm sim tsis zoo tuaj yeem yog qhov liab liab tshwm sim ua pob liab liab, khaus thiab dermatoses. Cov kab mob hypolipidemic yog lom rau cov leeg nqaij, vim li ntawd, nrog tus naj npawb ntawm cov yam ntxwv ntawm cov neeg los yog cov tshuaj siab, cov tsos ntawm myopathies, mob nqaij, mob txheej txheem hauv cov leeg, lawv qaug zog thiab qaug zog. Hauv qee qhov tsis tshua muaj tshwm sim, rhabdomyolysis tshwm sim.

Tsuas tshuaj thiab tswj hwm

Ua raws li kev kuaj mob, simvastatin tau sau tseg hauv cov tshuaj uas tus kws kho mob sau tseg. Nws txawv ntawm qhov kho tsawg kawg (10 mg) thiab ntau kawg ib hnub (80 mg). Cov tshuaj yuav tsum tau noj ua ntej noj mov, ib zaug ib hnub, nyiam dua thaum yav tsaus ntuj, ntxuav cia nrog cov dej ntshiab ntawm chav sov. Kev xaiv thiab txhaj tshuaj kho tau yog nqa nrog lub sijhawm sib luag tsis pub tsawg dua ib hlis.

Cov lus teb rau lo lus nug ntawm ntev npaum li cas coj Simvastatin los txhim kho kev noj qab haus huv tsuas yog muab tau los ntawm tus kws kho mob uas tuaj koom. Lub sijhawm ntawm cov chav kawm yog nyob ntawm kev kuaj mob, qhov hloov pauv ntawm tus kab mob thiab lipid profile ntsuas - LDL, triglycerides, cov roj (cholesterol) tag nrho.

Thaum cev xeeb tub thiab lactation

Simvastatin muaj cov teebmeem teratogenic thiab fetotoxic. Nws muaj peev xwm nkag mus rau qhov tso ntshav, yog li ntawd, thaum coj los kho thaum cev xeeb tub, nws tuaj yeem ua rau txoj kev loj hlob ntawm cov me nyuam hauv plab tsis xws luag thiab pathologies. Cov ntxhais ntawm kev muaj me nyuam uas muaj hnub nyoog uas yuav tsum tau siv tshuaj los ntawm cov pab pawg ntawm statins rau kev noj qab haus huv yuav tsum ua raws li kev tiv thaiv kom muaj txiaj ntsig kom zoo thoob plaws hauv kev kho mob.

Hauv kev xyaum tshuaj, kev siv tshuaj yeeb tsis yog siv, vim tias tsis muaj cov ntaub ntawv hauv chaw kho mob txog kev nyab xeeb thiab ua kom zoo li tus neeg ntawm Simvastatin rau cov neeg mob paum.

Nrog lub siab ua haujlwm tsis zoo

Nws yog ib qho tsim nyog los tswj lub siab ua haujlwm tsis muaj swb ob leeg ua ntej pib kev kho lipid-txo qis thiab thaum nws. Qhov ntsuas ntawm lub siab enzymes (ntshav dej hloov ntshav) tau tshawb xyuas, thiab ntau tus kuaj ntshav kuaj ntshav kuj tseem ua. Nrog cov kev hloov tas mus li hauv cov txiaj ntsig sim, cov tshuaj tso tseg.

Thaum tsis ua haujlwm lub raum

Cov neeg mob uas kuaj pom tias muaj mob me lossis mob pes tsawg theem ntawm lub raum lub raum tau tso cai sau tshuaj, tab sis nws raug nquahu kom tsis txhob txhaj ntau tshaj plaws. Hauv kev mob hnyav ntawm PN (lub raum tsis ua haujlwm), kev tsim cov tshuaj tsw qab muaj tsawg dua 30 ml ib feeb, lossis nrog rau kev siv tshuaj tom qab xws li cyclosporine, fibrates, dinazole, qhov ntau kawg ntawm cov tshuaj yog 10 mg ib hnub.

Simvastatin ntsiav tshuaj: yam tshuaj pab tau dab tsi

Kev qhia rau kev siv tshuaj muaj xws li:

thawj hypercholesterolemia (hom IIa thiab IIb) nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj nrog cov roj cholesterol tsawg thiab lwm yam kev ntsuas tsis siv tshuaj (kev hnyav thiab kev ua haujlwm hauv lub cev) hauv cov neeg uas muaj kev pheej hmoo ntawm kev txhim kho mob plawv atherosclerosis,
ua ke hypertriglyceridemia thiab hypercholesterolemia tsis kho los ntawm kev siv lub cev thiab kev noj haus tshwj xeeb,
kev txo qis hauv kev tshwm sim ntawm cov hlab plawv mob tsis tu ncua (hloov ischemic nres lossis mob stroke),
kev tiv thaiv ntawm myocardial infarction,
qeeb tus mob ntawm cov mob txhab ntshav atherosclerosis,
txo txoj kev pheej hmoo ntawm cov txheej txheem revascularization.

Cov lus qhia rau kev siv

"Simvastatin" tau noj ntawm qhov ncauj, thaum yav tsaus ntuj 1 lub sijhawm ntawm ib hnub hauv kev sib xyaw nrog cov dej uas yuav tsum tau. Lub sijhawm ntawm kev noj tshuaj tsis tas yuav cuam tshuam nrog kev noj mov.

Ua ntej pib txoj kev kho, tus neeg mob yog kws kho hypocholesterol, uas yuav tsum tau pom thoob plaws hauv kev kho mob.

Txog kev kho mob hypercholesterolemia, koob tshuaj pom zoo ntawm "Simvastatin" thaj tsam ntawm 10 txog 80 mg ib hnub ib zaug nyob rau yav tsaus ntuj. Rau cov neeg mob uas tsis tuaj yeem siv, qhov pom zoo thawj zaug ntawm cov tshuaj yog 10 mg. Qhov nyiaj pab ntau tshaj txhua hnub yog 80 mg.

Txoj kev xaiv (hloov) ntawm koob tshuaj yog qhov xav tau ntawm 4 lub lis piam. Hauv cov neeg mob feem ntau, cov txiaj ntsig zoo ntawm kev kho mob tau ua tiav thaum noj cov tshuaj hauv koob tshuaj ntau txog 20 mg / hnub.

Hauv kev kho mob rau cov neeg mob uas muaj mob plawv los yog muaj kev pheej hmoo siab ntawm nws txoj kev loj hlob, kev siv tshuaj zoo yog 20-40 mg / hnub. Hauv qhov no, kev pom zoo pom zoo thawj zaug hauv cov neeg mob no yog 20 mg / hnub. Txoj kev xaiv (hloov) ntawm koob tshuaj yuav tsum tau ua nyob rau ntawm kev ncua sijhawm ntawm 4 lub lis piam. Yog tias tsim nyog, qhov koob tshuaj yuav raug nce ntxiv rau 40 mg / hnub.

Rau cov neeg mob noj verapamil lossis amiodarone concomitantly nrog Simvastatin, koob tshuaj txhua hnub yuav tsum tsis pub ntau tshaj 20 mg.

Hauv cov neeg mob uas mob raum lossis mob raum tsis ua haujlwm, nrog rau cov neeg laus laus, kev hloov pauv ntawm cov tshuaj tsis tas yuav tsum ua.

Hauv cov neeg uas muaj homozygous kab mob hypercholesterolemia, koob tshuaj niaj hnub ntawm Simvastatin yog 80 mg hauv 3 faib koob tshuaj (20 mg thaum sawv ntxov, 20 mg thaum yav tav su thiab 40 mg thaum yav tsaus ntuj) lossis 40 mg thaum yav tsaus ntuj ib zaug ib hnub.

Hauv cov neeg mob uas mob raum tsis ua haujlwm lossis tau txais cyclosporine, gemfibrozil, danazol lossis lwm cov fibrates (tshwj tsis yog fenofibrate), nrog rau cov nicotinic acid ua ke nrog cov tshuaj, qhov kev pom zoo ntau kawg ntawm cov tshuaj yuav tsum tsis pub ntau tshaj 10 mg / hnub.

Pharmacological kev txiav txim

"Simvastatin", cov lus qhia rau kev siv qhia txog qhov no, - tus neeg tso tshuaj lipid-txo qis tau txais synthetically los ntawm cov khoom fermentation Aspergillus terreus yog cov lactone tsis muaj zog, ua rau lub cev tsis muaj dej hauv lub cev nrog kev tsim ntawm hydroxy acid derivative. Cov nquag metabolite inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), ib qho enzyme uas catalyzes pib tsim mevalonate los ntawm HMG-CoA.

Txij li thaum hloov ntawm HMG-CoA rau mevalonate yog ib theem thaum ntxov ntawm kev coj los ua ke ntawm cov roj (cholesterol), kev siv simvastatin tsis ua rau kev txuam nrog cov tshuaj sterols hauv lub cev. HMG-CoA yog qhov yooj yim metabolized rau acetyl-CoA, uas koom tes nrog ntau cov txheej txheem tsim khoom hauv lub cev.

"Simvastatin" ua rau cov ntshav txo qis ntawm triglycerides (TG), lipoproteins tsawg tsawg (LDL), lipoproteins tsawg tsawg (VLDL) thiab tag nrho cov roj (nyob rau hauv cov ntshav roj heterozygous tsev neeg thiab tsev neeg tsis muaj mob hyperchipolemia, nrog rau cov ntshav sib xyaw nrog hyperlipidemia, thaum muaj cov ntsiab lus ntawm cov roj (cholesterol), thaum muaj ntau ntxiv) qhov muaj feem cuam tshuam) vim yog kev txwv tsis pub cov cholesterol ua ke hauv cov siab thiab kev nce ntawm LDL receptors ntawm lub ntsej muag ntawm tes, uas ua rau kom muaj kev nce siab thiab catabolism ntawm LDL.

Nce cov ntsiab lus ntawm cov lipoproteins ntau ntom ntom (HDL) thiab txo qhov feem ntawm LDL / HDL thiab tag nrho cov roj (cholesterol) / HDL. Nws tsis muaj cov teebmeem mutagenic. Qhov pib ntawm kev tshwm sim ntawm cov nyhuv yog 2 lub lis piam tom qab pib kev tswj hwm, qhov siab tshaj plaws kho tau ua tiav tom qab 4-6 lub lis piam.

Cov nyhuv mob tsawv ntxiv nrog kev kho mob txuas ntxiv, nrog rau kev ua tsis tiav ntawm kev kho, cov ntsiab lus roj yuav rov qab los rau nws qib qub.

Sab sij huam

Txoj kev kho tuaj yeem tuaj yeem tsis tuaj yeem xav txog qhov teebmeem xws li:

anemia
palpitations
dyspepsia
alopecia
daim tawv nqaij ua pob
khaus
insomnia
paresthesia
nco qab tsis zoo
mob leeg
kiv taub hau
mob taub hau
peripheral neuropathy
mob raum tsis ua haujlwm (vim yog rhabdomyolysis),
pancreatitis
kab mob siab
tsawg potency
tsis muaj zog
mob plab
zawv plab
xeev siab, ntuav,
flatulence
cem quav
lub siab ua tsis taus haujlwm,
myasthenia gravis
asthenia
myalgia
mob hlwb
cholestatic mob daj ntseg,
mob leeg
rhabdomyolysis,
ua txhaum ntawm saj
qhov muag pom kev pom,
tsim cov kev mob hypersensitivity syndrome (angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, dermatomyositis, thrombocytopenia, eosinophilia, ESR ntau ntxiv, mob caj dab, mob caj pas, mob ntsws, ua kom lub ntsej muag, ua pa ntawm lub ntsej muag, ua tsis taus pa).

Analogues ntawm cov tshuaj "Simvastatin"

Cov analogues rau ntawm qhov nquag:

Simlo.
Dab Dab Ntxaug.
Holvasim.
Simvacol.
Simvalimite.
Zorstat.
Aries
Simvor.
Ib Sim Neej.
Zokor forte.
Simvakard.
Simvastatin Chaikafarma.
Simvastol.
Zokor.
Simvastatin Zentiva.
Actalipid.
Vasilip.
Vero Simvastatin.
Simvastatin Pfizer.
Atherostat.
Simvastatin Fereyn.

Cov pab pawg ntawm cov statins suav nrog cov tshuaj:

Tulip.
Holvasim.
Holetar.
Cov Atomax
Leskol forte.
Mertenil.
Aries
Pravastatin.
Rovacor.
Liptonorm.
Lovacor.
Vasilip.
Atoris.
Vazator.
Zorstat.
Cardiostatin.
Lovasterol.
Mevacor.
Kwv Txhiaj Ntsuag.
Lipobay.
Lipona.
Rosulip.
Tevastor
Atorvox.
Neeg Coob.
Lovastatin.
Medostatin.
Atorvastatin.
Leskol.
Liprimar.
Rosuvastatin.
Akorta.
Lipostat.
Lipoford.
Rosucard.
Tus tub sab.
Torvazin.
Apextatin.
Torvacard.
Atherostat.
Atocord.

Cov lus so thiab nqe

Tus nqi nruab nrab ntawm Simvastatin (10 mg ntsiav tshuaj No. 30) hauv Moscow yog 44 rubles. Hauv Kiev, koj tuaj yeem yuav cov tshuaj (20 mg No. 28) rau 90 hryvnias. Hauv Kazakhstan, cov khw muag tshuaj muab cov tshuaj analogue ntawm Vazilip (10 mg No. 28) rau 2060 tenge. Nws yog qhov muaj teeb meem kom nrhiav tau yeeb tshuaj hauv Minsk. Muaj los ntawm cov chaw muag tshuaj nrog cov tshuaj noj.

Hais txog "Simvastatin" kev kuaj xyuas tus neeg mob txawv. Qee tus neeg siv khoom tau lees paub tias cov tshuaj tiag tiag txo cov roj cholesterol, tab sis tib lub sijhawm lawv piav qhia ntau yam kev tsis zoo tiv thaiv keeb kwm ntawm tag nrho cov chav kawm ntawm kev kho hypocholesterol. Cov neeg mob uas muaj mob txhaws qog, ceeb toom qhov nce ntawm exacerbations thaum kho. Nrog rau kev kho mob ntev, muaj kev hloov ntawm lipid profile rau qhov zoo dua.

Cov kws kho mob cov tswv yim kuj sib qhia. Qee tus sau cia tias cov tshuaj tau ua tiav cov roj cholesterol tsawg thiab ua qhov zoo ntawm kev tiv thaiv atherosclerosis. Lwm tus ntseeg tias cov tshuaj yog qhov qub dhau lawm, muab qhov hnyav ntawm qhov tshwm sim tsis zoo, thiab qhov tshwm sim nyob rau hauv kev lag luam tshuaj ntawm Atorvastatin thiab Rosuvastatin, uas yog cov tshuaj tshiab.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv cov tshuaj antimycotic zoo ib yam li ketoconazole, itraconazole, kev siv erythromycin, cytostatics, koob tshuaj ntau ntau ntawm Vitamin PP (nicotinic acid) yog qhov ua kom tsis haum rau kev teem caij ntawm Simvastatin. Tag nrho cov tshuaj no muaj qhov tshwm sim ntawm myopathies thiab lwm yam kev cuam tshuam rau cov leeg mob hauv kev phiv. Thaum muab kev ua tiav ib txhij, lawv cov leeg mob toxicity ntxiv rau, yog li yuav luag ob npaug ntawm rhabdomyolysis ntu ntu.

Nrog lub sijhawm teem ntawm Simvastatin nrog cov tshuaj anticoagulant (warfarin, fenprocoumone), nws yog qhov yuav tsum tau soj ntsuam cov ntshav coagulogram tsis tu ncua, txij li thaum statins nce cov txiaj ntsig ntawm anticoagulants. Ib qho kev hloov pauv ntawm cov tshuaj lossis cov tshuaj yeeb tshuaj tawm yog nqa tawm tom qab INR tswj hwm.

Nws tsis tshua pom zoo kom siv cov kua txiv kab ntxwv qaub thaum lub sij hawm kev kho mob lipid-txo qis nrog cov statins. Qhov tso cai ntau kawg yog txog li 250 ml ib hnub. Cov dej haus tshiab no muaj CYP3A4 inhibitor protein, uas hloov pauv chaw muag tshuaj thiab chaw muag tshuaj ntawm Simvastatin.

Daim ntawv thov nta

Simvastatin yog cov tshuaj uas muaj ntau qhov tshuaj thiab kev mob tshwm sim, yog li ntawd nws tsuas yog kws kho mob tau sau tseg, raws li cov cim qhia nruj, thiab raug faib rau hauv cov khw muag tshuaj tsuas yog muab tshuaj. Lub sijhawm kho mob, ntsuas ntawm cov ntshav coagulation system (INR, APTT, lub sijhawm coagulation), lipid profile, daim siab ua haujlwm (ALT, AST enzymes) thiab lub raum kev ua haujlwm (creatinine tshem tawm, CPK) raug saib xyuas.

Tus nqi tshuaj

Tus nqi ntawm simvastatin yog mob me ntsis thiab pheej yig rau txhua tus neeg mob. Nyob ntawm thaj av thiab lub khw muag tshuaj cov cai, tus nqi kuj yuav txawv. Qhov nruab nrab, tus nqi ntawm cov tshuaj hauv Lavxias yog:

Dosage 10 mg, 30 pieces rau ib pob - los ntawm 40 txog 70 rubles.
Muab 20 mg, 30 daim rau ib pob - los ntawm 90 rubles.

Hauv cov chaw muag tshuaj Ukrainian, tus nqi ntawm Simvastatin yog 20-25 UAH thiab 40 UAH rau koob tshuaj 10 thiab 20 mg, feem.

Cov qauv ntawm simvastatin

Simvastatin muaj tag nrho pawg hauv kev lag luam kws tshuaj tag nrho cov analogues - generics nyob rau hauv lwm cov npe luam. Cov no suav nrog Vasilip, Aries, Alkaloid, Simlo, Simvastatin C3, Simgal, Vertex, Simvastol, Zokor. Cov tshuaj no yog txhais ua tau thiab tuaj yeem ua raws li tus neeg nyiam los ntawm tus kws kho mob, kev muaj peev nyiaj ntawm tus neeg mob thiab tus yam ntxwv ntawm cov nyhuv ntawm cov tshuaj rau ntawm tus neeg mob tshwj xeeb.

Dab tsi yog qhov zoo dua simvastatin lossis atorvastatin

Simvastatin thiab Atorvastatin tsis zoo li qub. Cov tshuaj no rau ntau tiam neeg ntawm statins: Atorvastatin - thawj, Simvastatin - thib peb. Lawv cov sib txawv hauv cov tshuaj nquag, qhia, contraindications, peculiarity ntawm kev cuam tshuam nrog lwm cov khoom siv kho mob.

Txhua tus tshuaj muaj nws tus kheej kho lub qhov thiab qhov zoo, yog li nws tsis tsim nyog los sib piv. Atorvastatin yog qhov ntau dua thiab ua yeeb yam sai sai nrog cov nyhuv ntev dua. Yog li ntawd, yog tias tsim nyog, kom tau txais kev hloov pauv sai, qhov zoo tau muab rau nws. Txawm li cas los xij, simvastatin, dhau los, yog cov tshuaj tsis hnyav uas muab cov kev mob tshwm sim tsawg dua thiab raug pom zoo siv nyob rau hauv cov theem me me ntawm lub raum thiab mob siab pathologies, tsis zoo li Atorvastatin.

Dab tsi yog qhov txawv ntawm simvastatin thiab rosuvastatin

Nruab nrab ntawm simvastatin thiab rosuvastatin muaj qhov sib txawv ntawm cov tshuaj yeeb dej caw, qhov profile ntawm cov hauj lwm zoo, qhia, contraindications, phiv thiab nqe tus nqi. Rosuvastatin feem ntau siv ntau dua los ntawm kev tiv thaiv qhov pom ntawm cov neeg mob uas muaj keeb kwm mob hnyav ntawm cov hlab plawv.

Kev Siv Tshuaj Xyuas

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob noj Simvastatin yog qhov nruab nrab. Cov kws kho mob nco ntsoov qhov muag muag muag tshuaj - cov kev mob tshwm sim tsis tshua muaj tshwm sim los ntawm nws, nws zoo sib xws nrog lwm cov tshuaj noj. Qhov txiaj ntsig zoo ntawm cov tshuaj yog qhov ua tau ntawm nws kev teem caij nrog concomitant kab mob ntawm lub raum lossis mob siab hauv lawv cov tsos mob me lossis nruab nrab. Txawm li cas los xij, nyob rau hauv cov hauj lwm zoo ntawm simvastatin yog me ntsis qis dua rau analogues ntawm lwm tiam ntawm statins, yog li ntawd, nws tsis tshua muaj siv rau kev kho hnyav.

Pharmacodynamics thiab pharmacokinetics

Simvastatin muaj qhov nqus tus nqi siab. Qhov siab tshaj plaws tau sau tseg tom qab 1.5-2.5 teev, tab sis tom qab 12 teev nws txo qis txog 90%. Hauv cov ntshav protein, cov feem ua kom muaj peev xwm tuaj yeem khi rau 95%. Rau simvastatin nrog metabolism hauv nyob rau hauv cov kab mob hepatic, qhov zoo ntawm "thawj dhau" yog tus yam ntxwv, thaum los ntawm hydrolysis ib qho kev nquag dag zog, beta-hydroxy acid, tau tsim. Qhov tseem ceeb ntawm kev nthuav dav yog los ntawm txoj hnyuv. Hauv daim ntawv tsis ua haujlwm, 10-15% ntawm cov tshuaj nquag raug tso tawm los ntawm cov hlaus.

Yuav ua li cas noj simvastatin?

Cov koob tshuaj txhua hnub ntawm cov tshuaj no rau cov neeg laus yog 1 t. (20-40 mg.) 1 p. ib hnub rau 30-40 feeb. ua ntej yuav pw, haus dej kom ntau.

Qhov siab kawg rau kev noj tshuaj txhua hnub yuav tsum tsis pub ntau tshaj 80 mg. (2 t.), Vim tias qhov no tuaj yeem cuam tshuam rau lub cev tsis zoo ntawm lub cev.

Lub chav kawm ntawm kev kho mob thiab koob tshuaj yog txiav txim siab los ntawm tus kws kho mob koom nrog tus kheej kiag rau txhua tus neeg mob, nyob ntawm qhov mob hnyav ntawm cov chav kawm ntawm tus kab mob tshwj xeeb ntawm lub cev.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov neeg qias neeg, mg

10/20/40 mg ntsiav tshuaj

simvastatin 10/20/40 mg

microcrystalline cellulose 70/140/210

ascorbic acid 2.5 / 5 / 7.5

gelatinized hmoov txhuv nplej siab 33.73 / 67.46 / 101.19

stearic acid 1.25 / 2.5 / 3.75

lactose monohydrate 21/42/63

polyvinyl cawv 2.33 / 4.66 / 6.99

silicon dioxide 0.75 / 1.50 / 2.25

titanium dioxide 0.97 / 1.94 / 2.91

Cov hlau oxide daj 0.28 / 0.56 / 0.84

liab hlau oxide 0.19 / 0.38 / 057

Tsuas tshuaj thiab tswj hwm

Ua ntej pib txoj kev kho, kev noj zaub mov hypocholesterol yog yam yuav tsum ua. Simvastatin noj ntawm qhov ncauj 1 lub sijhawm thaum yav tsaus ntuj, ntxuav cia nrog dej, tsis hais qhov noj mov li cas. Qhov ntau npaum li cas yog nyob ntawm vim li cas rau kev teem caij cov ntsiav tshuaj:

Hypercholesterolemia - thawj koob tshuaj yog 10 mg, qhov siab tshaj plaws yog 80 mg. Koob tshuaj hloov kho yog nqa tawm 1 zaug hauv ib hlis.
Ischemia, qhov kev pheej hmoo ntawm nws txoj kev loj hlob yog 20-40 mg.
Homozygous cov keeb kwm rau hypercholesterolemia - 20 mg 3 zaug ib hnub.
Cov kab mob ntsig txog lub raum - tsis pub ntau tshaj 10 mg rau ib hnub nrog ib txwm muaj creatinine (3 0.31 ml / min tuaj yeem hais tawm).
Rau cov neeg mob noj Verapamil, Amiodarone - ib koob tshuaj txhua hnub ntawm 20 mg.

Cov lus qhia tshwj xeeb

Thawj 1-3 hnub ntawm kev noj Simvastatin, kev nce bilirubin hauv cov ntshav thiab qib ntawm AST thiab ALT yuav raug pom. Vim li no, nws yog qhov yuav tsum tau ua qhov kev soj ntsuam ultrasound txhua 3 lub hlis (thaum noj 80 mg lossis ntau dua). Kev kho mob nres sai li sai tau thaum lub siab enzymes ntau dua li cov cai los ntawm 3 zaug. Hypertriglyceridemia ntawm 1.4, 5 hom yog contraindication rau kev siv tshuaj kho mob.

Cov tshuaj tuaj yeem ua rau txoj kev txhim kho myopathy, qhov tshwm sim uas yog rhabdomyolysis, kev ua haujlwm hauv lub raum. Cov ntsiav tshuaj muaj txiaj ntsig ob qho tib si hauv kev kho mob nrog cov tshuaj tiv thaiv cov kua tsib hauv cov kua qaub, thiab hauv kev kho tshuaj. Qhov kev ua tau zoo ntawm cov ntsiav tshuaj tuaj yeem ua kom zoo dua qub los ntawm kev siv lub zog hypocholesterol. Kev siv cov kua txiv kab ntxwv qaub thaum kho mob yog qhov xav tau heev.

Yeeb tshuaj sib cuam tshuam

Txhawb kev txhaj tshuaj ntawm simvastatin thiab noj tshuaj cyclosporine, danazole tuaj yeem ua rau rhabdomyolysis. Statin txhim kho cov nyhuv ntawm cov tshuaj tiv thaiv - Warfarin, Fenprokumon, uas tuaj yeem ua rau muaj kev pheej hmoo los ntshav. Digoxin concentration nce ntxiv nrog rau kev noj kom tsawg. Nws yog txwv tsis pub noj tshuaj nrog gemfibrozil. Txoj kev pheej hmoo ntawm myopathy yog vim muaj kev sib txuam nrog cov tshuaj hauv qab no:

Nefazodon.
Erythromycin.
Clarithromycin
Kev txhaj tshuaj tiv thaiv kab mob.
Ketoconazole, Itraconazole.
Fibrates.
Nicotinic acid nyob rau hauv cov koob tshuaj loj.
HIV tiv thaiv kabmob.

Noj ntau dhau

Cov tsos mob ntawm kev muab ntau tshaj yog tsis qhia tshwj xeeb. Txog kev kho, nws yog qhov tsim nyog los ntxias kev ntuav, yaug lub plab. Hauv qab no yog kev kho mob syndromic nrog kev soj ntsuam ntawm cov muaj kabmob hepatic. Nrog kev mob raum, kev siv cov tshuaj diuretic, kev tswj hwm cov tshuaj sodium bicarbonate tau pom zoo. Hemodialysis yog qhov tsis muaj txiaj ntsig, tab sis tuaj yeem ua tau raws li qhov xav tau. Nrog rhabdomyolysis, hyperkalemia kev txhim kho, uas yuav tsum muaj kev tso ntshav ntawm calcium chloride thiab gluconate, insulin nrog piam thaj.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Statin tshuaj yog tshuaj siv. Hauv qee lub tsev muag tshuaj, lawv tsis tas yuav tshuaj dab tsi. Cov tshuaj ntsiav tshuaj pom zoo kom khaws cov tshuaj hauv qhov chaw tsaus, txias ntawm qhov kub ntawm 15 txog 25 degrees. Cov khoom yuav tsum muaj kev tiv thaiv tshwj xeeb tshaj yog menyuam yaus. Lub txee lub neej ntawm cov khoom yog 24 lub hlis txij li hnub tso.

Analogs thiab hloov pauv rau tshuaj Simvastatin

Muaj cov npe tshuaj uas zoo ib yam hauv muaj pes tsawg leeg thiab ua rau simvastine. Cov tshuaj no suav nrog:

Vasilip yog ib qho qauv qhia ua tiav. Nws yog siv los kho hypercholesterolemia, kev tiv thaiv ntawm ischemia.
Simgal - siv los tiv thaiv kev txhim kho ntawm atherosclerosis, myocardial infarction.
Zokor - yog kho rau cov ntshav khov ntshav plasma tsawg.
Holvasim - pom zoo rau kev kho mob sib xyaw hyperlipidemia, ischemia ntev.
Sinkard - siv los tswj lub hlwb kev khiav lag luam, txo kev ploj tuag.

Hauv cev xeeb tub (thiab lactation)

Simvastatin yog sib txuam hauv cov tes cev xeeb tubvim muaj peev xwm ua rau muaj kev loj hlob ntau yam txawv txav hauv cov menyuam mos. Thaum kho, siv tshuaj thaivCov. Tsis muaj ntaub ntawv hais txog kev nkag mus ntawm cov khoom nquag mus rau niam mis. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias muaj kev pheej hmoo siab txog qhov tshwm sim ntawm simvastatin rau kev noj qab haus huv ntawm tus menyuam.

Kev tshuaj xyuas txog Simvastatin (kev xav ntawm kws kho mob, cov neeg mob)

Kev txheeb xyuas txog Simvastatin ntawm cov kab ntawv sib txawv. Cov neeg mob paub tseeb tias cov tshuaj tiag tiag ua rau cov cholesterol tsawg dua, tab sis tib lub sij hawm lawv qhia txog ntau yam kev tsis zoo tawm tsam ntawm cov keeb kwm yav dhau los ntawm tag nrho cov chav kawm ntawm kev kho hypocholesterol. Cov neeg mob uas muaj mob txhawm rau mob taub hau daim ntawv qhia tias tau nce siab zuj zus ntxiv thaum kho. Nrog rau kev kho mob ntev, muaj kev hloov ntawm lipid profile rau qhov zoo dua.

Cov kws kho mob tshuaj xyuas yog sib koom. Qee tus ntseeg tias cov tshuaj yog "qub tus neeg saib xyuas" thiab tau tawm ntawm nws tus kheej, muab qhov hnyav ntawm qhov tshwm sim tsis zoo, thiab cov tsos ntawm lub khw muag tshuaj Atorvastatin thiab Rosuvastatinuas muaj feem rau kev siv yeeb tshuaj ntawm ib tiam neeg tshiab. Lwm tus nco ntsoov tias cov tshuaj tau ua tiav cov roj cholesterol tsawg thiab ua qhov zoo ntawm kev tiv thaiv atherosclerosis.