Glibomet (Glibomet) - cov lus qhia rau kev siv

Cov tshuaj Glybomet muaj cov nyhuv hypoglycemic thiab hypolipidemic. Raws li cov lus qhia ntawm Glibomet, cov tshuaj ua rau cov kua dej hauv cov kua ntshav zais, uas tsim tawm los ntawm tib neeg cov leeg, ntxiv qhov rhiab rau insulin ntawm txhua daim ntaub so ntswg ntawm lub cev. Cov tshuaj tsim cov tshuaj tawm ntawm insulin, thaum inhibiting lipolysis nyob rau hauv cov ntaub so ntswg. Txhawb kev glycogenolysis nyob rau hauv daim siab, Glybomet txo kev tsim ntawm cov ntshav txhaws, ua rau muaj qhov cuam tshuam nrog antiarrhythmic. Cov tshuaj sib xyaw ua ke ntawm Glibomet, uas suav nrog glibenclamide thiab metformin, muaj kev sib xyaw ua ke ntawm tus neeg mob lub cev, thaum glibenclamide yog lub luag haujlwm rau tsim cov tshuaj insulin, thiab metformin txo cov ntshav qis thiab ua kom cov lipid metabolism zoo.

Cov Lus Qhia Glibometa

Glibomet yog siv los kho hom 2 mob ntshav qab zib mellitus, raws li txoj cai, tom qab kev noj zaub mov noj thaum nws tsis muaj txiaj ntsig. Glybomet kuj pib siv tom qab siv cov tshuaj hypoglycemic hauv qhov ncauj uas tsis muaj kev kho kom zoo. Kev txiav txim los ntawm kev tshuaj xyuas ntawm Glibomet, cov tshuaj muaj txiaj ntsig tshaj yog tias tus neeg mob ua raws li kev kho thiab noj haus.

Txoj kev siv Glybomet thiab dosages

Ua raws li cov lus qhia ntawm Glibomet, cov tshuaj yog noj ntawm qhov ncauj thaum noj mov. Nyob ntawm qhov xwm txheej uas cov metabolism hauv kev ua kom yuag nyob thiab ntshav qab zib cov ntshav nyob hauv tus neeg mob, noj ntau npaum li cas tau tsim, txhua qhov no tau ua tiav ib tus zuj zus, suav txog qhov xwm txheej ntawm tus neeg. Lawv pib coj Glybomet nrog 1, 2 lossis 3 ntsiav tshuaj, maj mam los rau ib lub koob tshuaj sib haum mus rau chav kawm ntawm tus kab mob. Qhov zoo tshaj plaws kom tsawg ntawm cov tshuaj Glibomet, raws li cov lus qhia, ob zaug ib hnub - thaum sawv ntxov thiab yav tsaus ntuj. Nws tsis pom zoo kom nce koob tshuaj ntawm ib hnub noj tshuaj ntau dua tsib ntsiav tshuaj.

Cov Txheej Txheem Tshaj Tawm rau Kev Siv Glibomet

Lub ntsiab contraindication rau kev noj cov tshuaj, raws li cov lus qhia ntawm Glibomet, yog hypersensitivity rau lub Cheebtsam ntawm cov tshuaj muaj. Cov tshuaj tsis tuaj yeem siv kuj tseem siv rau cov kabmob hauv qab no: mob ntshav qab zib tsis nco qab, mob ntshav qab zib precoma, mob ntshav qab zib tsawg, hom 1 mob ntshav qab zib mellitus. Kev siv yeeb tshuaj Glybometa yog txwv thaum cev xeeb tub thiab pub niam mis.

Phiv los ntawm Glybomet

Noj Glybomet tuaj yeem ua rau xeev ntuav thiab ntuav heev. Kev txheeb xyuas Glybomet qhia tau hais tias muaj kev fab tshuaj muaj peev xwm ua tau, cov nyhuv hauv lub cev tsis ua haujlwm, uas ua rau txo qis cov ntsiab lus ntawm cov ntshav liab, platelets thiab granulocytes hauv cov ntshav. Nyob rau tib lub sijhawm, hemolytic anemia, kab mob siab thiab mob cholestatic tab tom tsim. Hauv qee kis ntawm kev siv tshuaj Glibomet, arthralgia thiab hyperthermia tau pom. Kev tshuaj xyuas ntawm Glybomet paub meej txog cov ntaub ntawv ntawm kev nce siab ntawm cov protein nyob hauv cov zis thiab ntawm qhov tawm ntawm photosensitivity.

Glybomet's cov lus piv txwv

Hauv qee kis, nrog muaj kabmob, tshuaj Glibomet tuaj yeem hloov nrog analogues. Xws li cov analogues ntawm Glibomet yog cov tshuaj Glyukovans thiab Glyurenorm. Noj ob Glibenclamide thiab Metformin tshuaj noj thaum tsis muaj lwm yam tshuaj tuaj yeem siv los ua ib qho tshuaj tiv thaiv kab mob ntawm Glibomet, tab sis cov nyhuv yuav tsis zoo dua thaum noj ib hom tshuaj.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov ntsiav tshuaj Glibomet yog tsim cov khoom xyaw nquag:

• Metformin hydrochloride - 400 mg,
• Glibenclamide - 2.5 mg.

Glibomet's ntu pab yog magnesium stearate, microcrystalline cellulose, colloidal silicon dioxide, glycerol, gelatin, pob kws hmoov txhuv nplej siab, talc.

Hauv blisters rau 20 ntsiav tshuaj.

Cov Tshuaj Hauv Tshuaj

Glibomet yog qhov ncauj sib xyaw ua ke hypoglycemic tshuaj cuam tshuam txog cov kev tso dag ntawm biguanide thiab sulfonylurea ntawm lub cim thib ob. Nws yog tsiag ntawv los ntawm txiav txim siab pancreatic thiab kev lom zem ntxiv.

Glibenclamide yog tus tswvcuab ntawm pawg II tiam sulfonylureas thiab ua kom lub zog ntawm cov tshuaj insulin los ntawm kev txo qis qis rau kev ua rau pancreatic beta-cell piam thaj. Cov tshuaj tsub kom nce insulin rhiab heev thiab qhov ntau ntawm nws cov lus cog rau lub hom phiaj hlwb, ua kom lub cev tso tawm ntawm insulin, nce nws cov txiaj ntsig ntawm qhov nqus ntawm cov piam thaj los ntawm daim siab thiab cov leeg, thiab inhibits lipolysis hauv adipose nqaij. Nws cov nyhuv pom nyob rau qib thib ob ntawm cov kua dej tso pa tawm.

Metformin belongs rau cov qeb ntawm cov loj loj. Nws stimulates peripheral rhiab heev ntawm cov ntaub so ntswg rau kev cuam tshuam ntawm insulin (nce qib ntawm khi ntawm insulin rau receptors, ua rau muaj zog ntawm insulin ntawm qib postreceptor), inhibits qhov nqus ntawm cov piam thaj hauv cov hnyuv, inhibits gluconeogenesis thiab muaj txiaj ntsig cuam tshuam rau lipid metabolism, pab txo lub cev qhov hnyav hauv cov neeg mob ntshav qab zib mellitus, thiab tseem muaj cov nyhuv fibrinolytic vim yog kev thaiv cov nqaij mos plasminogen activator inhibitor.

Cov nyhuv hypoglycemic ntawm Glibomet yog pom 2 teev tom qab kev tswj hwm thiab kav rau 12 teev. Kev sib xyaw ua ke ntawm ob qho kev sib xyaw ntawm cov tshuaj, uas muaj nyob rau hauv kev ua kom tau qhov sulfonylurea derivative los ua ke nrog cov tshuaj tua kabmob endogenous (nyhuv ua rau lub cev nqaij daim tawv) thiab cov kev cuam tshuam ncaj qha ntawm biguanide ntawm adipose thiab cov leeg nqaij (qhov tseem ceeb nce ntxiv nyob rau hauv qabzib (ntxiv cov txiaj ntsig ua rau lub cev), ua rau lub siab ua rau lub siab (txo cov ntshav qabzib). koob tshuaj qee qhov ntsuas kom txo tau cov tshuaj ntsiab lus ntawm txhua yam. Qhov no txwv tsis pub ntau dhau ntawm kev txhawb nqa ntawm pancreatic beta hlwb thiab txo kev pheej hmoo ntawm tsis ua haujlwm ntawm cov kabmob no, thiab tseem ua rau muaj kev nyab xeeb ntawm kev noj tshuaj hypoglycemic thiab txo cov xwm txheej tshwm sim.

Cov Tshuaj Pharmacokinetics

Glibenclamide nrog kev kub ceev thiab siv tag nrho (84%) yog nqus hauv cov hnyuv. Qhov siab tshaj plaws tau tiav 1-2 teev tom qab tswj hwm. Cov tshuaj khi rau cov ntshav protein ntau li ntawm 97% thiab yuav luag txhua qhov teeb meem hauv lub siab, ua rau lub cev tsis muaj zog. Glibenclamide tsuas yog tawm 50% los ntawm ob lub raum thiab 50% nrog bile. Ib nrab-lub neej yog 5-10 teev.

Qhov ntsuas ntawm kev nqus ntawm metformin hauv cov hnyuv zom zaub mov muaj ntau heev. Cov compound yog muab faib nrawm thoob plaws cov ntaub so ntswg thiab kev xyaum tsis khi rau cov ntshav protein. Metformin tsis yog qhov ua kom tshwm sim hauv lub cev thiab tawm hauv lub raum thiab qee cov hnyuv. Qhov kev tshem tawm ib nrab-lub neej yog kwv yees li 7 teev.

Cov lus qhia rau kev siv Glibomet: txoj kev thiab qhov ntau npaum li cas

Cov ntsiav tshuaj noj ntawm ncauj nrog noj mov.

Tus kws kho mob tau sau ntawv noj ntau npaum cas thiab kho lub sijhawm ib leeg zuj zus raws li kev ntsuas pom tseeb, coj mus rau hauv tus lej ntawm cov ntshav qabzib hauv cov ntshav thiab lub xeev ntawm carbohydrate metabolism.

Thawj koob tshuaj feem ntau yog 1-3 ntsiav tshuaj hauv ib hnub. Thaum kho, tus neeg mob xaiv cov koob tshuaj kom ua tiav qhov ua kom cov ntshav qabzib nyob ruaj khov.

Qhov siab tshaj txhua hnub koob ntawm Glybomet yuav tsum tsis pub tshaj 6 ntsiav tshuaj.

Noj ntau dhau

Nrog kev noj tshuaj ntau dua ntawm Glibomet, nws muaj peev xwm tsim tau cov kab mob lactic acidosis los ntawm kev ua ntawm metformin, thiab mob ntshav qab zib vim tshwm sim los ntawm kev ua ntawm glibenclamide.

Cov tsos mob ntawm tus kab mob lactic acid yog lub zog ua kom tsis muaj zog, txo qis ntshav siab, tsis nco qab ntshav siab, qaug zog, tsis meej pem thiab tsis nco qab, txo qis, ua pa nyuaj, mob leeg, raws plab, xeev siab thiab ntuav.

Cov tsos mob ntawm tus mob ntshav qab zib muaj xws li mob taub hau, zoo li ntshai, ua rau lub cev puas ib ntus, tsis muaj kev sib koom tes ntawm kev txav, kev nqhis dej, pw tsaug zog, kev ntxhov siab, tshee tshee, kab mob hauv lub qhov ncauj, tsis muaj zog, pallor ntawm daim tawv nqaij, nce hws, palpitations, tshaib plab. Kev nce ntshav nce siab tuaj yeem ua rau poob qab hau ntawm kev tswj tus kheej thiab tsaus muag.

Yog tias muaj kev ua xyem xyav ntawm kev txhim kho ntawm cov kab mob lactic acidosis, Glibomet yuav tsum tau tshem tawm tam sim ntawd thiab tus neeg mob xa mus sai sai mus rau tsev kho mob. Txoj kev kho mob zoo tshaj plaws rau kev siv tshuaj ntau dhau yog kev kho mob hemodialysis.

Cov ntshav qab zib me me tuaj yeem daws tau los ntawm kev noj ib qho me me ntawm cov piam thaj, dej qab zib lossis cov zaub mov uas muaj cov carbohydrates ntau (ib khob dej qab zib, taum qab, zib ntab).

Yog tias tsis nco qab, nws raug nquahu kom txhaj 40-80 ml ntawm 40% kua qabzib (dextrose) txhaj tshuaj, thiab tom qab ntawd muab qhov tshuaj 5-10% dextrose daws. Ib qho kev tswj hwm ntxiv ntawm 1 mg ntawm glucagon yog tso cai subcutaneously, intramuscularly lossis intravenously. Yog hais tias tus neeg mob tsis rov qab zoo, nws yog qhov yuav tsum tau rov ua ntu zus ntawm kev nqis tes ua. Thaum tsis muaj qhov tshwm sim hauv tsev kho mob loj, yog qhov tseem ceeb rau kev saib xyuas zoo.

Cov lus qhia tshwj xeeb

Nws yog ib qho tsim nyog kom tsum tsis txhob noj Glibomet thaum cov tsos mob ntawm cov kab mob lactic acidosis tshwm sim rau kev ua kom tsis muaj zog, ntuav, mob plab, mob leeg, thiab tam sim ntawd sab laj nrog kws kho mob.

Nws raug nquahu kom koj noj cov tshuaj nrog kev saib xyuas tsis tu ncua ntawm theem ntawm creatinine hauv cov ntshav: rau cov neeg mob uas lub raum ua haujlwm - tsawg kawg 1 zaug hauv ib xyoos, rau cov neeg mob uas muaj creatinine concentration hauv cov ntshav nyob ze rau qhov tsis pub tshaj ntawm cov cai thiab rau cov neeg laus - 2-4 zaug hauv ib xyoos.

Glybomet yuav tsum nres 2 hnub ua ntej txoj kev npaj phais mob siv tshuaj loog (pob txha caj qaum lossis tshuaj pleev ib ce). Txuas ntxiv rau cov tshuaj nrog kev rov pib noj ntawm qhov ncauj noj haus, tab sis tsis tau ua ntej 2 hnub tom qab kev phais, yog tias lub raum tsis ua haujlwm paub tseeb.

Thaum lub sijhawm kho mob, ceev faj yog qhia thaum ua cov haujlwm uas muaj kev phom sij thiab tsav tsheb, vim tias muaj qhov tshwm sim ntawm kev txhim kho hypoglycemia thiab, vim li ntawd, qhov txo qis ntawm psychomotor cov tshuaj tiv thaiv thiab muaj peev xwm mloog zoo.

Qhov ua tau zoo ntawm kev kho mob yog los ntawm kev ua raws li cov kws kho mob tau sau tseg, nws cov lus pom zoo hais txog kev ua haujlwm ntawm lub cev thiab kev noj zaub mov, thiab kev tshuaj xyuas cov ntshav qabzib.

Thaum siv Glibomet, koj yuav tsum tsis txhob haus cawv, vim tias ethanol tuaj yeem ua rau lub ntsej muag hypoglycemia thiab / lossis disulfiram zoo li cov tshuaj tiv thaiv (mob plab, ntuav, xeev siab, hnov ​​tau kub ntawm lub cev thiab lub ntsej muag, kiv taub hau, mob taub hau, tachycardia) Cov.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm Glybomet yog nce ntxiv nrog kev tswj hwm tib lub sijhawm ntawm cov beta-blockers, coumarin derivatives (warfarin, syncumar), allopurinol, cimetidine, monoamine oxidase inhibitors (MAO), oxytetracycline, sulfanilamides, chloramphenicol, phenylbutazone, perilefenamide amide , sulfinpyrazone, miconazole (thaum noj ntawm qhov ncauj), ethanol.

Qhov ua rau lub ntsej muag hypoglycemic txo cov kev sib txuam nrog glucocorticosteroids, adrenaline, tshuaj tiv thaiv qhov ncauj, thiazide diuretics thiab barbiturates, kev npaj tshuaj thyroid.

Concurrent administration ntawm beta-blockers tuaj yeem npog cov tsos mob ntawm kev ua qog ntshav qab zib, ntxiv rau kev tawm hws ntau dhau.

Nrog rau kev siv tib lub sijhawm ntawm Glibomet nrog cimetidine, qhov kev pheej hmoo ntawm kev tsim muaj cov kab mob lactic acidosis nce ntxiv, nrog cov tshuaj anticoagulants, lawv cov nyhuv zuj zus ntxiv.

Tus neeg mob txoj kev pheej hmoo ntawm kev tsim cov kab mob lactic acidosis nce nrog kev tshawb nrhiav xoo hluav taws xob nrog kev siv tshuaj tiv thaiv iodine uas muaj cov tshuaj tiv thaiv tsis zoo.

Glibomet's analogues yog: Amaril, Avandamet, Avandaglim, Gluconorm, Glukovans, Glimecomb, Galvus Met, Glyukofast, Bagomet Plus, Combogliz, Metglib, Yanumet.

Kev txheeb xyuas ntawm Glibomet

Ntawm cov neeg mob uas niaj hnub noj cov tshuaj, feem ntau muaj kev tshuaj xyuas zoo txog Glibomet, txawm li cas los xij, muaj kev xa mus rau cov kev mob tshwm sim me. Ntau tus neeg mob uas tau kuaj pom tias tus mob ntshav qab zib hom 2 mellitus sib txuas nrog kev noj cov tshuaj Glibomet nrog lwm cov tshuaj, yog li lawv tsis tuaj yeem lees paub qhov ua tau zoo ntawm kev kho nrog cov tshuaj. Qee tus neeg tsis txaus siab rau cov kev mob tshwm sim los ntawm txoj kev kho no, thiab lawv thiaj li hloov mus rau Glibomet analogues, uas qhia tau tias yuav tsum muaj ib tus neeg mus kom ze rau hauv kev teem caij kho.

Lub xub ntiag ntawm ob qho kev sib txuam hauv Glibomet tuaj yeem hauv qee kis ua rau tus neeg tsis mob siab rau yeeb tshuaj. Nws yuav tsum nco ntsoov tias yog tias mob ntshav qab zib mellitus, tsuas yog tus kws kho mob tuaj yeem txiav txim siab qhov tsim nyog ntawm kev sau tshuaj rau cov tshuaj no, tsim kho kev kho mob thiab kho qhov tshuaj.

Tsuas tshuaj thiab tswj hwm

Glybomet yog noj ntawm qhov ncauj thaum noj mov.

Qhov ntau npaum li cas thiab kev siv sijhawm ntev npaum li cas ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob koom nrog ib tus zuj zus, nyob ntawm seb muaj ntshav qabzib nyob hauv cov ntshav thiab lub xeev ntawm carbohydrate metabolism.

Thawj qhov tshuaj ntawm Glibomet yog 1-3 ntsiav tshuaj hauv ib hnub, nrog kev kho kom haum tom qab kom ua tiav qib siab ntawm cov piam thaj hauv cov ntshav. Ntau tshaj 6 ntsiav tshuaj ntawm cov tshuaj yuav tsum tsis txhob siv ib hnub.