Ofloxin muaj nyob rau hauv daim ntawv puag ncig biconvex ntsiav tshuaj ntawm cov xim dawb tsis muaj qhov tsis muaj ntxhiab tsw thiab tsw ntxhiab tsw. Cov ntsiav tshuaj raug coated thiab muaj kev pheej hmoo sib kis. Nyob ntawm seb qhov ntau npaum li cas, kev txua yog nyob ntawm ib qho ntawm ob sab "200"Lossis"400". Ntawm lub kink - nias dawb loj.

Cov hlwv cell muaj qhov txhab tso rau hauv qhov chaw thawv ntawv.

Txhua pob ntawv yuav tsum muaj cov lus qhia ntxaws ntxiv rau kev siv tshuaj.

Pharmacodynamics thiab pharmacokinetics

Ofloxacin Nws yog cov tshuaj tua kab mob nrog cov kab mob ua rau muaj ntau yam ntawm cov kab mob bactericidal kev txiav txim siab. Nws zwm rau pab pawg. fluoroquinolonesCov. Ofloxacin muaj cov ntsiab lus tseem ceeb rau enzyme DNA gyrase, uas muab supercoiling ntawm cov kab mob DNA. Cov tshuaj cuam tshuam rau DNA cov saw hlau, uas ua kom muaj kab mob tuag taus.

Ofloxacinmuaj lub siab ua haujlwm tiv thaiv cov kab mob me me uas tsim cov β-lactamases, thiab tseem siv los tawm tsam xws li atypical microbacteria sai li sai tau Cov kab mob Enterobacteriaceae (Salmonella, Serratia, Citrobacter, Klebsiella, Yersinia), Escherichia coli, Enterobacter spp., Shigella spp., Providencia spp., Proteus spp.

Cov tshuaj tseem ua tau zoo tiv thaiv staphylococcus (suav nrog rau penicillin-ua thiab methicillin-resistant hom (Tus mob chlamydia trachomatis, Chlamydia mob ntsws, Mycoplasma pneumoniae, Mycobacterium tuberculosis Mycobacterium leprae, Ureaplasma urealyticum).

Cov tshuaj kuj qhia tau hais tias muaj txiaj ntsig zoo hauv kev kho mob ntawm cov kab mob tshwm sim los ntawm cov kab mob hauv qab no: Pasteurella multocida, Pseudomonas spp., Brucella melitensis, Haemophilus influenzae, Campylobacter sp., Neisseria meningitidis, Branhamella catarrhalis, Vibrio sp., Pseudomonas aeruginosa.

Nws raug nquahu kom siv cov tshuaj tiv thaiv no nrog kev rov ua dua tshiab. Helicobacter pylori, Acinetobacter sp., Neisseria gonorrhoeae, Haemophilus ducreyi, Gardnerella vaginalis.

Ofloxin tsis tshua nquag tiv thaiv cov kis mob uas tshwm sim los ntawmstreptococci ntawm pawg A, B, C. Kuj, anaerobes, nrog rau kev zam ntawm Clostridium perfringensCov. Hauv cov xwm txheej no, ofloxacin muaj cov nyhuv tsawg thiab, yog tias ua tau, nws zoo dua siv lwm cov tshuaj los ua kom qhov kev rov ua tiav ntawm cov kab mob no ploj mus.

Cov kab mob Anaerobic yog qhov tsis txaus siab rau cov tshuaj Fusobacterium spp., Bacteroides spp., Peptococcus spp., Thiab Peptostreptococcus spp.

Ofloxin yog tsaug zog in relation to Treponema pallidum.

Xuas

Thaum noj cov tshuaj, qhov nqus tau ua tiav (95%) thiab nrawm. Bioavailability ntau dua 96%. Сmax thaum noj cov tshuaj hauv 100 mg, 300 mg thiab 600 mg txog 1 mg / l, 3.4 mg / l thiab 6.9 mg / l, ntsig txog. Nrog rau ib qho tshuaj ntawm cov tshuaj hauv qhov ntau npaum ntawm 200 mg thiab 400 mg, Cmax nce mus txog 2.5 μg / ml thiab 5 μg / ml. Nws yuav tsum raug sau tseg tias kev noj zaub mov kom poob qis kom nqus tau, tab sis tsis cuam tshuam loj heev txog kev nyab xeeb.

Kev xa Khoom

Kev khi ntawm ofloxacin nrog cov plasma protein yog 20-25%. Qhov pom tseeb Vd ncav cuag 100 litres.
Cov tshuaj yooj yim nkag mus rau ntau lub cev thiab kua ntswg (lacrimal thiab cerebrospinal kua, tso zis, qaub ncaug, zais pa tawm, thiab lwm yam.) Ofloxacin kuj ywj siab nkag mus rau qhov tsis muaj teeb meem thiab BBB, thiab tawm hauv cov kua mis. Qhov peev xwm tob tob tob ntawm cov tshuaj mus rau hauv cov kua dej ua kua dej ua kua txawv txawv li ntawm 14 txog 60%. Ofloxacin tsis txuam nrog.

Kev zom zaub mov

Kev zom zaub mov tshwm sim hauv lub siab. Dimethylofloxacin thiab ofloxacin N-oxide yog tsim los.

Chaw Sau Ntawv

T1 / 2 thaum muab qhov ncauj, tsis hais lub koob tshuaj, tawm tom qab 4,5-7 teev. Kev tshem tawm yog ua los ntawm lub raum (75-90%) thiab kua tsib (4%). Kev tshem tawm ntxiv yog kwv yees li 20%. Cov neeg mob raum lossis mob siab tsis txaus yuav tsum nco ntsoov tias T1 / 2 ntawm cov tshuaj nce siab. Nrog ib koob tshuaj 200 mg xwb, ofloxacin tuaj yeem kuaj pom hauv cov zis hauv 20-24 teev.

Kev ntsuas rau siv

Ofloxin tau ua pov thawj nws tus kheej hauv kev kho mob ntawm:

• mob hnyav ua pa ua pa (bronchiectatic kab mob, mob ntsws rwj,mob ntsws),
• Cov mob ENT (otitis media, sinusitis, pharyngitis, laryngitis / tshwj mob tonsillitis /),
• kis kab mob ntawm cov pob txha thiab pob qij txha,
• cov nqaij mos thiab cov tawv nqaij sib kis,
• cov kab mob sib kis thiab mob ntawm lub plab (kab mob plab, ua kom mob plab hnyuv / ua kab mob) cov kab mob enteritis /),
• mob raum (pyelonephritis),
• mob txeeb zig (urethritis, cystitis),
• mob pelvic (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• mob qhov chaw mos heev (orchitis, colpitis, epididymitis, gonorrhea, prostatitis),
• mob hlwb,
• mob chlamydia,
• cov kab mob sib kis yooj yim nrog Aids,
• mob qhov muag (pom mob pob txha, cov kab mob ua mob rau lub ntsej muag, mob blepharitis, dacryocystitis, meibomite, keratitis).

Ofloxin tseem nquag siv:

• nyob rau hauv kev tiv thaiv kev sib kis kis mob tom qab kev phais mob sib txuas nrog kev tshem tawm ntawm lub cev txawv teb chaws lossis qhov muag raug mob,
• nrog txoj kev kho kom zoo tuberculosis,
• hauv kev tiv thaiv kev kis kab mob hauv cov neeg mob nrog txhaj tshuaj tiv thaiv kab mob (neutropenia).

Cov Yuav Tsum Muaj

Koj yuav tsum tsis kam noj Ofloxin:

• ntawm piam thaj-6-phosphate dehydrogenase tsis txaus,
• ntawm qaug dab peg (suav txog keeb kwm),
• ntawmtxos txoj kev qaug dab peg (suav nrog tom qab mob stroke, taub hau raug mob lossis cov kev ua rau hauv nruab nrab lub paj hlwb).

• cov neeg hnub nyoog qis dua 18 xyoo
• cov neeg uas mob siab tsis haum rau cov tshuaj ntawm cov tshuaj.
• poj niam muaj me nyuam
• poj niam thaum lactation.

Nrog kev ceev faj, cov tshuaj yuav tsum tau siv rau hauv cov neeg muaj kab mob cuam tshuam nrog kev ua haujlwm tsis zoo ntawm lub hlwb thiab cerebral arteriosclerosisCov. Ntawm mob raum tsis ua hauj lwm thiab organic qhov chaw mob ntawm qhov chaw nruab nrab hauv lub paj hlwb nws raug nquahu kom xaiv cov tshuaj kho nrog qhov zoo ntawm kev ua, tab sis muaj kev phom sij tsawg.

Sab sij huam

Thaum lub sijhawm kho nrog Ofloxin, tus neeg mob yuav tsis xis nyob thiab raug txom nyem los ntawm:

• Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, mob plab, mob plab(suav nrog mob ncauj plab), nce qhov kev ua haujlwm ntawm hepatic transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.
• Los ntawm peripheral poob siab thiab CNS:mob taub hau, kiv taub hau, ntxhov siab ntawm qhov txawv txav, tshee, cramps, loog thiab paresthesias ntawm kev nqua, kev npau suav heev, npau suav phem, puas siab puas ntsws, txhawj xeeb,txob tausphobias, kev ntxhov siab, kev tsis meej pem, kev pom zoonce siab intracranial.
• Los ntawm hnov qhov muag plab hnyuv siab raum: xim pom kev cuam tshuam, diplopia,kev ntxhov siab nyob rau hauv kev saj, hnov ​​lus, hnov ​​tsw thiab sib npaug.
• Los ntawm hlab plawv: tachycardia, vasculitis, cev qhuav dej.
• Los ntawm musculoskeletal system: tendonitis, myalgia, arthralgia, tendosynovitis, leeg txhaws.
• Los ntawm hematopoietic tshuab: leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic thiab aplastic anemia.
• Los ntawm cov kab mob zis: mob interstitial mob nephritis, lub raum khiav tsis zoo, hypercreatininemia,nce urea cov ntsiab lus.
• Kev tsis haum tshuaj:daim tawv nqaij ua pob khaus, khaus, urticaria, tshuaj tiv thaiv mob ntsws, ua xua nephritis, eosinophilia, kub taub hau, Quincke's edema, bronchospasm, Stevens-Johnson syndrome, Lyell syndrome, photosensitivity, erythema multiforme, ceeb toom tsis nco qab.
• Kev kho kom haum Dermatological: pom mob hemorrhages (petechiae), mob ntshav liab los yog mob ntshav liab, ua pob liab vog rau leeg, vasculitis.
• Thiab kuj: dysbiosis, superinfection, hypoglycemia(hauv cov neeg mob mob ntshav qab zib), vaginitis.

Cov lus qhia rau kev siv ofloxine (qauv thiab ntau npaum li cas)

Vim tias qhov tseeb ntawm Ofloxin yog siv los kho ntau hom kabmob, ntau npaum li cas ntawm cov tshuaj tua kabmob no tau xaiv ib tus zuj zus thiab tsis yog nyob ntawm qhov mob hnyav thiab qhov chaw ntawm tus kabmob, tabsis tseem nyob ntawm tus neeg mob cov mob. Ofloxin 400 mg cov lus qhia yuav tsum tau muab tshwj xeeb rau daim siab thiab lub raum ua haujlwm.

Cov neeg laus raug txhaj tshuaj 200 mg 2 zaug ib hnub, lossis 400 mg 1 zaug nyob rau ib hnub. Qhov siab tshaj plaws hauv ib hnub yuav tsum tsis pub tshaj 800 mg. Lub chav kawm ntawm kev kho yog txiav txim siab los ntawm kev nkag siab ntawm tus kab mob thiab feem ntau yog 7-10 hnub. Siv cov tshuaj kom zoo dua thaum sawv ntxov 30-60 feeb ua ntej noj mov. Haus cov ntsiav tshuaj nrog ib qho dej tsawg.

Ua ntej koj pib noj cov tshuaj, koj yuav tsum nco ntsoov sab laj nrog kws kho mob, vim tias ntau npaum li cas hauv kev kho mob ntawm ntau yam kab mob tuaj yeem sib txawv.

Kev sib txuam

Thaum noj cov tshuaj hauv, nws yuav tsum nco ntsoov tias qhov txo kom tsawg ofloxacincov khoom noj khoom noj uas muaj cov tshuaj calcium, aluminium, magnesium, thiab cov ntsev muaj hlau, thaum lawv ua cov tshuaj tsis haum. Nws yuav tsum tau xyuas kom meej tias cov sijhawm nruab nrab ntawm kev tswj hwm ntawm Ofloxin thiab cov tshuaj yeeb dej caw no yog tsawg kawg 2 teev.

Ntawm kev txais tosofloxacin25% txo theophylline tshem tawm thiab nws raug nquahu hauv qhov xwm txheej no kom txo tau qhov koob theophylline.

Tshwj xeeb yuav tsum tau them rau cov tshuaj uas thaiv tubular zais cia, txij li lawv cov kev coj ua ib txhij nrog Ofloxin tuaj yeem nce qhov siab ntawm ofloxacin hauv cov ntshav.

Kev Sau Ntawv Glibenclamide hauv plasma kuj yog vam khom Ofloxin.

Ofloxin yuav tsum tsis txhob coj nrog Vitamin K kev thaiv kev, vim tias qhov no yuav cuam tshuam loj heev rau tus mob ntshav coagulation system.

Derivatives nitroimidazolethiab methylxanthinesthaum noj ua ke yuav ua rau kev txhim kho cov teebmeem neurotoxic, thiab GKS nce kev pheej hmoo ntawm cov leeg pob txha, uas yog qhov tshwj xeeb tshaj yog rau cov neeg laus.

Kev noj ofloxin nrog cov tshuaj uas daws cov zis hauv lub cev yuav ua rau muaj kev pheej hmoo tshwm sim thiab kev loj hlob nephrotoxic cuam tshuamthiabcrystalluria.

Hnub tas sij hawm

Ofloxin muaj lub neej txee ntawm 3 xyoos.

Tam sim no, Ofloxin muaj txog 20 analogues los ntawm cov tuam txhab domestic thiab txawv teb chaws. Cov tshuaj nrov tshaj plaws niaj hnub no yog: Zanocin, Ofloxacin, OflocidthiabLoflox.

Kuj cov qauv analogues ntawm cov tshuaj nquag muaj: Vero Ofloxacin, Glaufos, Danzil, Uniflox, Phloxal.

Ofloxine Kev txheeb xyuas

Ofloxin tus qhab nia ntawm cov ntawv sib txawv nws txawv ntawm 1 txog 5 rau ntawm 5-point nplai.

Tom qab tshuaj xyuas qhov kev tshuaj xyuas ntawm cov neeg tuaj saib rau kev kho mob, peb tuaj yeem xaus lus tias cov neeg mob uas tau txais kev kho mob tag nrho tau txaus siab rau cov txiaj ntsig kho. Cov qhab nia qis rau cov tshuaj feem ntau tau muab los ntawm cov neeg qhua rau leej twg Ofloxin ua rau muaj kev phiv ntau tshaj plaws. Feem ntau, ntawm cov chaw sib tham, cov neeg mob yws yws ntawm kev mob hnyav hauv plab, tsis qab lostsos xyau, tsis muaj zog, tsaug zog thiab txawm tsaus ntujlus txhais.

Isloloin puas yog tshuaj tua kab mob los yog tsis?

Ntau qhov kev sib tham ntawm cov laj thawj tau mob siab rau qhov teeb meem no. Thiab tom qab ntawd cov kws tshaj lij tau qhia meej meej tias Ofloxin yog cov tshuaj tua kab mob zoo heev, thiab qhia cov neeg mob uas muaj cov tshuaj no ua rau muaj kev xav tsis zoo los xaiv cov tshuaj uas tsis zoo rau kev kho.

Tsis muaj xov xwm qhia txog cov tshuaj Ofloxin ntawm Wikipedia.

Ofloxacin

Cov nqi hauv cov khw muag tshuaj hauv online:

Ofloxacin yog cov tshuaj tiv thaiv kabmob muaj kabmob uas muaj qhov ntau ntawm cov kab mob bactericidal kev txiav txim siab. Cov neeg koom nrog pab pawg ntawm fluoroquinolones.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm cov tshuaj tau xaiv ib tus zuj zus, raws li cov xwm txheej dav dav ntawm tus neeg mob, lub raum thiab mob siab, kev ua txhaum loj thiab thaj chaw ntawm kev kis tus kab mob thiab rhiab ntawm cov kab mob me.

Coated ntsiav tshuaj

Cov ntsiav tshuaj yog npaj rau kev tswj hwm qhov ncauj ua ntej lossis thaum noj mov. Lawv yuav tsum nqos tag nrho, yam tsis ntxo, ntxuav nrog dej.

Cov koob tshuaj pom zoo rau cov neeg laus yog 200-800 mg ib hnub twg hauv 2 koob tshuaj 2 zaug. Lub sijhawm tiv thaiv yog 7-10 hnub. Yog tias qhov koob tshuaj txhua hnub tsis ntau tshaj 400 mg, nws tuaj yeem tsim tawm hauv ib koob, zoo dua thaum sawv ntxov.

Hauv cov kab mob gonorrhea mob siab, Ofloxacin yog siv nyob rau ntawm ib koob ntawm 400 mg ib zaug.

Txoj kev lis ntshav daws

Txoj kev hais daws tau muab tshuaj rau tib leeg.

Thawj koob tshuaj Ofloxacin yog 200 mg txhaj rau tshuaj (hauv 30-60 feeb). Thaum tus neeg mob tus mob hloov kho, lawv pauv mus rau cov tshuaj nyob hauv ib qho tshuaj txhua hnub.

• Kev kis mob ntawm qhov chaw mos thiab raum - 100-200 mg 2 zaug ib hnub,
• Cov mob txeeb zig - 100 mg 1-2 zaug ib hnub,
• Kev kis mob thiab kis kab mob ntawm cov kabmob ENT kabmob, ua pa ntawm lub plab, mob plab, nqaij mos thiab tawv nqaij, pob qij txha thiab pob txha - 200 mg 2 zaug hauv ib hnub (yog tias tsim nyog, nce qhov koob rau 400 mg 2 zaug hauv ib hnub),
• Kev tiv thaiv kev kis mob rau cov neeg mob uas lub cev tsis muaj zog - 400-600 mg ib hnub.

Yog tias lub raum lub raum tsis ua haujlwm (kev tsim muaj peev xwm tshem tau 20-50 ml / min), ib koob tshuaj yuav tsum raug txo los ntawm 50% ntawm qhov nruab nrab koob tshuaj (yog tias cov tshuaj noj 2 zaug hauv ib hnub) lossis ib koob tag nrho yuav tsum tau muab tshuaj, tab sis 1 zaug ib hnub. Nrog creatinine tshem tawm tsawg dua 20 ml / min, ib koob tshuaj yog 200 mg, thiab tom qab ntawd 100 mg rau ib hnub txhua lwm hnub.

Nrog peritoneal lim ntshav thiab hemodialysis, Ofloxacin yog tshuaj 100 mg rau txhua 24 teev.

Nrog daim siab ua haujlwm, qhov ntau tshaj plaws hauv ib hnub yog 400 mg.

Rau cov menyuam yaus uas muaj mob hnyav, cov tshuaj tau tawm hauv qhov nruab nrab ib hnub 7,5 mg / kg lub cev qhov hnyav, qhov ntau kawg yog 15 mg / kg.

Lub sijhawm tiv thaiv yog nyob ntawm kev nkag siab ntawm tus kab mob thiab cov duab hauv qhov chaw kuaj mob. Kev kho yog txuas ntxiv rau 3 hnub ntxiv tom qab qhov ploj ntawm cov tsos mob ntawm tus mob sib kis thiab hloov kho ntawm lub cev kub. Nrog rau qhov tsis yooj yim tso zis mob hnyav, cov chav kawm ntawm kev kho mob yog 3-5 hnub, nrog salmonellosis - 7-8 hnub.

Tshuaj pleev

Ofloxacin tshuaj pleev yog siv tshuaj pleev. Cov tshuaj yog tso rau qis tawv muag ntawm lub qhov muag cuam tshuam (ointment sawb 1 cm ntev, uas sib raug rau 0.12 mg ofloxacin) 2-3 zaug hauv ib hnub. Nrog rau kev mob chlamydial, cov tshuaj siv 5-6 zaug ib hnub.

Lub chav kawm ntawm kev kho mob tsis pub ntev tshaj 2 lub lim tiam (mob chlamydial xav tau kev kho mob ntev dua - ntawm 4 txog 5 lub lis piam).

Cov lus qhia tshwj xeeb

Ofloxacin tsis yog siv tshuaj rau kev xaiv rau kev mob ntsws los ntawm pneumococci. Tsis tau npaj rau kev kho mob ntawm tus mob tonsillitis.

Thaum lub sijhawm kho mob, ncaj qha tshav ntuj thiab UV tiv thaiv kev tsis ua haujlwm (ziab lub txaj, cov roj mercury-quartz teeb).

Ntau tshaj 2 lub hlis kom siv cov tshuaj no tsis pom zoo.

Thaum muaj kev fab tshuaj tsis haum thiab tshwm sim los ntawm lub hauv nruab nrab cov hlab hlwb, Ofloxacin yuav tsum tau txiav tawm. Nrog kev pom zoo pseudomembranous colitis, kev tswj hwm qhov ncauj ntawm metronidazole thiab vancomycin yog qhov pom zoo.

Yog hais tias cov tsos mob ntawm cov leeg muaj tshwm sim, kev kho mob yuav tsum tau txiav tawm tam sim ntawd, tom qab ntawd Achilles leeg yuav tsum tsis muaj immobilized thiab cov kws phais neeg mob pob txha.

Cov poj niam tsis pom zoo kom siv cov tshuaj tampons zoo li tampons thaum lub sijhawm kho mob tshuaj, vim tias muaj qhov pheej hmoo ntawm kev tsim tus mob candidiasis.

Thaum lub sij hawm siv Ofloxacin, cov lus tsis pom qhov tsis zoo muaj peev xwm ua tau nrog txoj kev bacteriological rau kev kuaj mob ntsws qhuav.

Hauv cov neeg mob predisposed thaum kho nrog tshuaj, nquag tawm tsam ntawm porphyria thiab kev ua phem zuj zus ntawm chav kawm ntawm myasthenia yog ua tau.

Hauv cov neeg mob uas lub raum tsis zoo los yog hepatic muaj nuj nqi, lub plasma qhov siab ntawm ofloxacin yuav tsum tau saib xyuas. Thaum muaj mob hepatic lossis lub raum tsis ua haujlwm, qhov kev pheej hmoo ntawm kev phiv lom muaj ntau dua.

Thaum kho, cawv yuav tsum zam.

Hauv thaum yau, Ofloxacin tsuas yog siv rau hauv cov xwm txheej uas muaj kev hem thawj rau lub neej thiab nws tsis tuaj yeem siv lwm yam, muaj cov kuab lom tsawg dua. Hauv qhov no, qhov sib piv ntawm cov txiaj ntsig uas xav tau thiab cov kev pheej hmoo ntawm kev mob tshwm sim yuav tsum raug txiav txim siab.

Thaum lub sijhawm kho mob, nws yog ib qho tsim nyog yuav tsum tsis txhob ua rau kev ua haujlwm muaj kev phom sij thiab tsav tsheb.

Thaum siv cov Ofloxacin tshuaj pleev, cov iav muag muag yuav tsum tsis txhob hnav. Vim tias kev tsim kho tau ntawm photophobia, nws raug nquahu kom siv cov tsom iav thiab tsis txhob raug ntev ntev rau lub hnub ci ci.

Tshuaj pleev tsis tau txhaj rau hauv chav hauv ntej ntawm qhov muag lossis subconjunctival.

Yeeb tshuaj sib cuam tshuam

Ofloxacin tsub kom cov concentration ntawm glibenclamide hauv cov ntshav ntshav, txo theophylline kev tshem tawm los ntawm 25%.

Tubular secretion thaiv cov tshuaj, furosemide, cimetidine thiab methotrexate nce ntshav plasma concentration ntawm ofloxacin.

Nrog rau kev siv cov tshuaj methylxanthines thiab nitroimidazole ib txhij, thiab tsis siv tshuaj tiv thaiv tsis haum tshuaj, qhov ntxim nyiam ntawm kev tsim cov teebmeem neurotoxic ntau ntxiv.

Thaum ua ke nrog glucocorticosteroids, txoj kev pheej hmoo ntawm txoj leeg leeg hlob zuj zus, tshwj xeeb tshaj yog rau cov neeg laus.

Citrates, carbonic anhydrase inhibitors thiab sodium bicarbonate ntau ntxiv kev pheej hmoo ntawm nephrotoxic teebmeem thiab crystalluria.

Nrog rau kev tswj hwm tib lub sij hawm nrog kev tiv thaiv tua kab mob tsis txaus ntawm cov vitamin K, nws yog qhov yuav tsum tau soj ntsuam lub xeev ntawm cov ntshav coagulation system.

Ofloxacin tov yog tshuaj sib xyaw nrog Ringer txoj kev daws teeb meem, 5% cov piam thaj (dextrose) tov, isotonic NaCl daws thiab 5% kev daws teeb meem fructose

Thaum siv cov tshuaj nyob rau hauv daim ntawv ntawm tshuaj pleev ib txhij nrog lwm cov tshuaj pleev qhov muag / tee, qhov luv ntawm tsawg kawg 15 feeb yuav tsum pom, thaum Ofloxacin siv kawg.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ofloxacin yog ib yam khoom muaj txiaj ntsig ofloxacin, ib hom tshuaj yeeb tshuaj yog tsim nyob rau hauv:

1. Ib qho kev daws teeb meem rau Txoj kev lis ntshav, lub ntshiab ntsuab-daj, hauv 1 ml ntawm cov uas muaj 2 mg ntawm lub ntsiab feem. Lwm yam tshuaj yog: sodium chloride, disodium edetate dihydrate, muaj zog hydrochloric acid, dej d / thiab. Cov tshuaj raug muag hauv qhov ntau npaum 100 ml hauv vials tsis muaj iav,
2. Cov ntsiav tshuaj, coated nrog cov zaj duab xis dawb, biconvex puag ncig, nrog cov ntsiab lus ofloxacin hauv qhov ntau npaum li 400 lossis 200 mg. Cov khoom xyaw ua haujlwm: poloxamer, pob kws hmoov txhuv nplej siab, crospovidone, magnesium stearate, talc, lactose monohydrate, povidone. Cov lus sib xyaw ntawm lub plhaub suav nrog: titanium dioxide, macrogol, talc, hypromellose. Nws raug muag hauv 10 lossis 7 ntsiav tshuaj hauv pob ntawv ntawm tes, contour packs. 1 lossis 2 pob khoom rau hauv ib lub thawv.

Clinical thiab pharmacological pawg: ib qho tshuaj tua kab mob ntawm pab pawg fluoroquinolone.

Vimo Vimloxin tshuaj?

Ofloxin tau ua pov thawj nws tus kheej hauv kev kho mob ntawm:

• kis kab mob ntawm cov pob txha thiab pob qij txha,
• cov nqaij mos thiab cov tawv nqaij sib kis,
• mob raum (pyelonephritis),
• mob txeeb zig (mob zis, mob tso zis),
• mob rau daim npluag qhwv
• mob chlamydia
• AIDS muaj feem kis kab mob
• muaj kab mob ntawm cov mob hauv plab ntswj (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• muaj mob rau cov chaw mos (orchitis, colpitis, epididymitis, gonorrhea, prostatitis),
• cov kab mob sib kis thiab mob ntawm lub plab (muaj kab mob ntawm txoj hnyuv, mob ua ke / nrog rau kev zam ntawm cov kab mob enteritis /),
• ua pa nyuaj rau cov hlab ntsws (txoj hlab ntsws, mob ntsws, mob ntsws),
• kev kis mob ntawm ENT plab hnyuv siab (mob otitis media, sinusitis, pharyngitis, laryngitis / tshwj tsis yog cov mob tonsillitis /),
• mob rau qhov muag (pom mob, kab mob ua paug rau lub qhov muag, mob tawm pob, mob dacryocystitis, meibomite, keratitis).

Ofloxin tseem nquag siv:

• nyob rau hauv kev tiv thaiv kev sib kis kis mob tom qab kev phais mob sib txuas nrog kev tshem tawm ntawm lub cev txawv teb chaws lossis qhov muag raug mob,
• nrog txoj kev kho mob ntsws qhuav,
• hauv kev tiv thaiv kev sib kis ntawm cov neeg mob uas tiv thaiv kab mob (neutropenia).

Dosage daim ntawv

200 mg, 400 mg zaj duab xis-ntsiav tshuaj txheej

Ib ntsiav tshuaj muaj

cov tshuaj nquag - ofloxacin 200 mg, 400 mg,

tus zam: cov hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, povidone K30, sodium starch glycolate, magnesium lossis calcium stearate, calcium carboxymethyl cellulose

plhaub muaj pes tsawg leeg: polyethylene glycol 6000, titanium dioxide (E 171), hypromellose 2910.

Cov ntsiav tshuaj coated, los ntawm dawb mus rau xim nyob rau hauv cov xim, tshuaj ntsiav zoo li tus, nrog rau lub cim thiab kos duab, ntawm ib sab tes cov kev pheej hmoo yog tsab ntawv "G", ntawm qhov tod - tus lej "200" - rau ntau npaum ntawm 200 mg.

Cov ntsiav tshuaj coated, los ntawm dawb mus rau xim nyob rau hauv cov xim, tshuaj ntsiav zoo li tus, nrog rau lub cim thiab kos duab, ntawm ib sab tes cov kev pheej hmoo yog tsab ntawv "G", ntawm qhov tod - tus naj npawb "400" rau kev noj tshuaj ntawm 400 mg.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Kev nqus tau tom qab noj tau nrawm thiab ua tiav. Qhov siab tshaj plaws hauv cov ntshav ntshav tau tiav hauv 1-3 teev tom qab ib koob ntawm 200 mg. Kev tshem tawm ib nrab-lub neej yog 4-6 teev (tsis hais los ntawm lub koob).

Hauv raum tsis ua haujlwm, cov koob tshuaj yuav tsum tau txo.

Tsis pom muaj qhov sib txuam nrog rau kev noj qab haus huv nrog zaub mov kom pom.

Cov Tshuaj Hauv Tshuaj

Ofloxacin yog tshuaj tua kabmob ntawm pawg quinolone, uas muaj cov nyhuv bactericidal. Lub tshuab tseem ceeb ntawm kev txiav txim yog qhov tshwj xeeb inhibition ntawm cov kab mob enzyme DNA gyrase. Lub DNA gyrase enzyme tau koom nrog hauv DNA replication, hloov pauv, kho, thiab rov ua kom tiav. Kev txwv tsis pub ntawm DNA gyrase enzyme ua rau kev ncab thiab kev puas tsuaj ntawm cov kab mob DNA thiab ua rau cov kab mob tuag.

Antibacterial spectrum ntawm kev nkag siab ntawm cov kab mob me me mus rau ofloxacin.

Cov kab mob me me nkag siab ntawm ofloxacin: Dab Tsi Staphylococcusaureus(suav nrog methicillin tiv tausStaphylococci),Dab Tsi Staphylococcusphaum mob daim tawv nqaij,Neisseriahom,Esherichiacoli,Citrobtab sisdaim tawv,Klebsiella,Enterobacter,Hafnia,Kev ua Proteus(suav nrog indole-zoo thiab indole-negative),Haemophiluskhaub thuas,Chlamydie,Legionella,Gardnerella.

Cov kab mob sib txawv nrog lub rhiab sib txawv rau ofloxacin: Streptococci,Serratiamarcescens,PseudomonasaeruginosathiabMycoplasmas.

Cov kab mob me me tiv (tsis raug mob) rau ofloxacin: muab ua piv txwv Bacteroideshom,Tus kab mob Eubhom,Fusobacteriumhom,Peptococci,Peptostreptococci.

Tsuas tshuaj thiab tswj hwm

Ofloxacin yuav tsum tau sau tseg raws kev tshawb fawb microbiological thiab kev soj ntsuam ntawm qhov rhiab ntawm microorganisms.

Dosage nyob ntawm hom thiab qhov mob ntawm tus kab mob, nrog rau kev nkag siab zoo rau cov kab mob me me thiab lub siab thiab lub raum kev ua haujlwm.

Rau cov neeg mob laus, cov koob tshuaj yog 200 - 800 mg ib hnub.

Qhov tau txais tshuaj ntau txog 400 mg ib hnub twg tuaj yeem tsim nyob rau hauv 1 koob tshuaj, nyiam dua thaum sawv ntxov, ntau dua koob tshuaj yuav tsum muab faib ua ob zaug. Feem ntau, cov tshuaj ib leeg yuav tsum tau coj ntawm kwv yees sib npaug.

Tsawg dua qhov mob txeeb zig

Cov tshuaj ib txwm noj yog 200 rau 400 mg ofloxacin Cov mob txeeb zig

Kev noj tshuaj li ib txwm ib txwm yog 400 mg ofloxacin ib hnub, nce rau 400 mg ob zaug ib hnub, yog tias tsim nyog.

Cov kab mob ua pa qis dua

Kev noj tshuaj li ib txwm tau 200 mus rau 400 mg ofloxacin ib hnub, nce rau 400 mg ob zaug ib hnub, yog tias tsim nyog.

Nyuaj urethral thiab ncauj tsev menyuam gonorrhea

Ib koob tshuaj ntawm 400 mg.

Cov tsis mob neococcal ua mob rau txoj hlab zis thiab ncauj tsev menyuam

Koob tshuaj ib zaug xwb 400 mg, tuaj yeem faib ua 2 koob.

Kev kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos

Kev noj tshuaj li ib txwm ib txwm yog 400 mg ofloxacin ob zaug ib hnub.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Rau cov neeg mob uas lub raum tsis zoo, lub koob tshuaj uas tau qhia hauv lub rooj hauv qab no yog kev pom zoo:

Ib koob tshuaj, mg *

Cov zaus noj cov tshuaj ib hnub

Qhov nyob nruab nrab ntawm kev nkag mus, h

Tsis tas yuav txhaj koob tshuaj

50 - 20 ml / min (ntshiab cov creatinine 1.5-5.0 mg / dl)

Pharmacological kev txiav txim

Cov tshuaj antimicrobial fluoroquinolone Tshuaj Ofloxin yog qhov muaj peev xwm ntau, cov ntsiav tshuaj muaj cov nyhuv bactericidal, uas yog, lawv ua rau cov kab mob tuag ntawm tus kab mob pathogenic. Kuv yuav sau nrog kev hwm txog cov tshuaj tua kab mob me me uas kev npaj tshuaj muaj txiaj ntsig zoo li cas: Salmonella spp, Brucella spp, Chlamydia spp, Yersinia enterocolitica, Enterococcus faecalis, Proteus spp, Vibrio cholerae, Serratia marcescens, Haemophiluseronfesseroceronferererererererererererererer Campylobacter jejuni, Aeromonas hydrophila, Bordetella pertussis.

Ntxiv rau, cov tshuaj ua rau cov kab mob zoo li no: Staphylococcus aureus, Citrobacter spp, Gardnerella vaginalis, Mycobacterium tuberculosis, Mycoplasma pneumoniae, Staphylococcus epidermidis, Streptococcus pyogenes, Mycoplasma hominis, Acinetobacter sppppleraxrax , Neisseria meningitidis, Escherichia coli, Clostridium perfringens, Bordetella parapertussis, Listeria monocytogenes, Shigella spp, Helicobacter pylori, Ureaplasma urealyticum, Vibrio parahaemolyticus, Haemophilus influenzae, Hafnia spp.

Tom qab noj Ofloxin, nws yog nqus los ntawm 95%, txog tib feem pua ​​yog cov bioavailability ntawm cov tshuaj. Protein khi yog 25%. Ofloxacin nkag mus rau hauv qee cov kua hauv lub cev, zoo li mus rau hauv ntau cov ntaub so ntswg. Tsis nthuav tawm (tsis sau ntau ntxiv). Ib nrab-lub neej ntawm cov tshuaj no kav ntev txog li 7 teev. Cov tshuaj txiav tawm hauv daim siab. Cov kev hloov pauv tsis tau, tawm hauv cov zis.

Kev qhia daws teeb meem

Diav ofloxacin raug txiav txim siab los ntawm tus kws kho mob uas tau mus kawm, nyob ntawm qhov mob hnyav thiab hom ntawm tus neeg kis tau.

Ofloxacin rau kev lis ntshav: ib koob tshuaj 200-400 mg (1-2 lub raj mis) 2 r / s nrog ib ncua sijhawm ntawm 12 teev (rau cov neeg laus uas lub raum muaj nuj nqi). Hauv lub raum tsis ua hauj lwm, thaum creatinine tshem tawm ntau tshaj 50 ml / min, tsis tas yuav hloov cov koob tshuaj. Nrog rau kev tshem tawm ntawm 20-50 ml / min, 200 mg yog siv hauv qhov pib hloov, thiab tom qab ntawd 100 mg / hnub. Nrog rau kev tshem tawm tsawg dua 20 ml / min, thov rau hauv ib pib ntawm 200 mg, tom qab ntawd 100 mg ib zaug txhua 2 hnub. Nrog daim siab ua haujlwm, qhov koob tshuaj tsis dhau 400 mg / hnub. Txoj kev lis ntshav daws yog muab tshuaj rau txoj dej ntws tsawg kawg yog ib nrab ib teev.

Nrog kev txhim kho nyob rau hauv cov mob feem ntau thiab muaj qhov tshwm sim zoo rau cov tshuaj, Txoj kev lis ntshav yog hloov nrog sab hauv ib qho ntawm tib qho tshuaj. Lub sijhawm kho yog 7-10 hnub.

Cev xeeb tub thiab lactation

Kev siv cov tshuaj Ofloxacin thaum cev xeeb tub yog contraindicated.

Vim hais tias Vim hais tias ofloxacin kis mus rau niam mis, kev siv Ofloxacin Zentiva yog sib xyaw nrog kev muaj feem phom sij rau tus menyuam. Yog tias tsim nyog, nws txoj kev siv yuav tsum txiav txim siab txog kev txiav kev pub niam mis.

Hla kev sib txuam yeeb tshuaj

Ofloxacin cuam tshuam tsis zoo thaum noj hauv cov zaub mov uas muaj cov calcium, potassium thiab magnesium ntau dua. Yog li, nruab nrab ntawm kev noj mov nrog cov tshuaj no thiab cov tshuaj yuav tsum siv sijhawm ntev li 2 teev.

Cov tshuaj uas thaiv cov hlab ntsws kom zais cia, ua ke nrog Ofloxin, nce ntxiv ntawm cov khoom tseem ceeb hauv plasma. Yog li, kev siv cov nyiaj no yuav tsum tau kho nrog ceev faj. Ofloxin 200 hauv kev sib xyaw nrog cov vitamin K muaj qhov tsis zoo rau cov ntshav coagulation.

Tsis txhob noj cov tshuaj tib lub sijhawm ua ke nrog alkalizing zis. Qhov no tuaj yeem ua rau muaj cov kab mob crystallization thiab nephrotoxic teebmeem.

Ofloxin analogues

Cov yam ntxwv ntawm cov tshuaj nquag:

• Vero Ofloxacin,
• Glaufos,
• Danzil
• Zanocin,
• Zoflox,
• Oflo,
• Oflox
• Ofloxabol,
• Ofloxacin
• Ofloxin 200
• Oflomac,
• Oflocid,
• Oflocide Forte
• Tseem ceeb
• Tariferide
• Taritsin,
• Uniflox
• Phloxal.

Xim: kev siv cov analogues yuav tsum pom zoo nrog tus kws kho mob koom.

Tus nqi nruab nrab ntawm OFLOXACIN, ntsiav tshuaj hauv khw muag tshuaj (Moscow) 200 rubles.

Cia rau cov neeg mob

Khaws tsis pub ntau tshaj 3 xyoos hauv qhov chaw qhuav, deb ntawm lub teeb, ntawm qhov kub txog 10-25 ° C. Kev daws rau Txoj kev lis ntshav yog ncaj qha txwv tsis pub kom khov.

Kuv tuaj yeem hais tias kuv tau raug mob los ntawm cystitis los ntawm kuv cov hluas, yog li kuv twb paub txhua txoj kev kho rau tus mob cystitis. Tab sis ofloxin tau raug sau rau kuv los ntawm kws kho mob urologist tsuas yog plaub lub hlis dhau los thiab pom zoo nws ua cov tshuaj uas muaj zog heev thiab siv tau. Tau kawg, Kuv tau mus dhau tag nrho cov kev kho mob, tab sis thoob plaws txhua lub sijhawm kuv tsis xis nyob, kuv tau hloov pauv ntawm txhua yam, txhua yam zaub mov qab zoo li chalk, yog li kuv yuav tsis zoo siab rau qhov kev kho mob no.

Cov tshuaj zoo. Kuv haus los ntawm prostatitis, nws tau los ua ob peb zaug yooj yim dua, tom qab ntawd tsuas yog nrog cov nyhuv hloov tau yooj yim. Qhov tseeb, thaum tus kab mob tua, ces qhov mob ploj mus sai heev.

Nyeem tsawg kawg cov lus qhia smartprost! Nws tsis kho dab tsi!

Vim li cas tom qab ntawd urologists hais tias ntse yog yooj yim rau kev tiv thaiv ntawm exacerbations?