Glyclazide ntsiav tshuaj 30 mg: cov lus qhia rau kev siv

Cov tshuaj tua ntshav hypoglycemic, uas yog ib tug khaws cia ntawm sulfonylurea II tiam. Tsim kho kev tsim cov tshuaj insulin los ntawm β-hlwb thiab rov kho nws lub cev kev nthuav qhia. Kev noj cov tshuaj txo lub sijhawm txij li lub sijhawm noj mov kom txog thaum pib lub cev cov kua dej, vim nws rov qab tso rau thawj theem (thaum ntxov) ntawm kev zais thiab txhim kho qib thib ob. Txo cov ncov qab zib kom nce siab tom qab noj mov. Ua rau cov nqaij mos rhiab heev rau tshuaj insulin.
Ntxiv rau, nws txo qhov kev pheej hmoo. mob ntsws vwmlos ntawm kev txuag kev sib xyaw thiab kev nplaum platelet suavrov qab los physiological parietal fibrinolysistxhim kho microcirculation. Cov nyhuv no yog qhov tseem ceeb vim tias nws txo qhov txaus ntshai ntawm cov teeb meem formidable - hais qhia tawm thiab microangiopathiesCov. Nrog rau cov ntshav qab zib mob nephropathy, muaj qhov txo qis proteinuria tawm tsam keeb kwm ntawm kev kho mob nrog cov tshuaj no. Nws tiv thaiv kev txhim kho atherosclerosis, vim nws muaj anti-atherogenic zog.

Cov yam ntxwv ntawm daim ntawv ntau npaum Gliclazide MV muab cov tshuaj kho kom zoo thiab tswj cov suab thaj hauv 24 teev.

Cov Tshuaj Pharmacokinetics

Kev nqus sai sai hauv cov hnyuv, qib ntawm nqus tau yog siab. Qhov siab tshaj plaws (thaum noj 80 mg) raug txiav txim siab tom qab 4 teev. Kev sib txuas lus nrog cov protein nce txog 97%. Kev ua kom sib npaug yog ua tiav tom qab kev tswj hwm rau 2 hnub. Cov tshuaj tua kab mob hauv daim siab mus rau 8 metabolites. Txog li 70% yog kho tawm ntawm lub raum, hnyuv - 12%. Kev tshem tawm ib nrab-lub neej ntawm dog dig gliclazide yog 8 teev, ua ntev mus rau 20 teev.

Cov Yuav Tsum Muaj

• insulin dependant ntshav qab zib mellitus,
• ketoacidosis,
• mob ntshav qab zib coma,
• mob raum / mob siab ua hauj lwm zoo,
• congenital lactose intolerance, malabsorption syndrome,
• tib lub sij hawm txais tos nrog Danazol lossis Phenylbutazone,
• hnub nyoog txog 18 xyoo
• kev tiv thaiv tsis haum
• cev xeeb tub, lactation.

Nws yog kho nrog ceev faj thaum muaj hnub nyoog laus, nrog cov khoom noj tsis xwm yeem, hypothyroidism, Kev Ntsuas Ncajloj chav kawm Ischemic mob plawvthiab hais atherosclerosis, adrenal tsis txauskev kho mob ncua ntev glucocorticosteroids.

Sab sij huam

• xeev siab, ntuav, mob plab,
• thrombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
• ua xua vasculitis,
• daim tawv nqaij ua pob, khaus,
• daim siab ua hauj lwm,
• pom kev pom
• ntshav qog(nyob rau hauv cov ntaub ntawv ntawm overdose).

Glyclazide, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Glyclazide ntsiav tshuaj sau ntawv hauv qhov pib thawj zaug ntawm 80 mg, noj 2 zaug hauv ib hnub 30 feeb ua ntej noj mov. Hauv lub sijhawm yav tom ntej, cov koob tshuaj tau raug hloov kho, thiab qhov nruab nrab txhua hnub tau txais yog 160 mg, thiab qhov ntau tshaj yog 320 mg. Glyclazide MB ntsiav tshuaj yuav pom cov ntsiav tshuaj tso tawm tsis tu ncua. Lub peev xwm ntawm kev hloov thiab cov koob tshuaj hauv qhov no yog txiav txim los ntawm tus kws kho mob.

Glyclazide MB 30 mg siv 1 zaug hauv ib hnub thaum lub sijhawm noj tshais. Qhov hloov pauv koob tshuaj yog tau ua tom qab 2 lub lim tiam ntawm kev kho mob. Nws tuaj yeem yog 90 -120 mg.

Yog tias koj plam cov ntsiav tshuaj koj tsis tuaj yeem noj dua ib zaug. Thaum hloov lwm cov tshuaj txo cov ntshav qab zib nrog qhov no, lub sijhawm hloov pauv tsis tas yuav tsum muaj - lawv pib noj nws hnub tom qab. Kab tias muaj kev sib xyaw nrog lojmuas, tshuaj insulinalpha glucosidase inhibitors. Rau me rau hauj sim lub raum tsis ua hauj lwm taw nyob rau tib koob tshuaj. Hauv cov neeg mob uas muaj kev phom sij ntawm hypoglycemia, siv tsawg kawg.

Noj ntau dhau

Kev noj ntau dhau yog tshwm sim los ntawm cov tsos mob ntawm tus mob ntshav qab zib: mob taub hau, qaug zog, tsis muaj zog ntau, tawm hws, palpitations, nce ntshav siab, arrhythmiatsaug zog ntxhov siabtxhoj puab heev, txob taus, ncua kev tsis haum, cuam tshuam lub zeem muag thiab hais lus, tshee hnyokiv taub hau cramps, bradycardiatsis nco qab.

Nrog muaj nqees ntshav qogtsis muaj qhov tsis nco qab zoo, txo qhov tshuaj ntawm cov tshuaj lossis nce qhov ntau ntawm cov carbohydrates nrog cov zaub mov.

Nyob rau hauv kev mob ntshav khov ntau heev, yuav tsum tau mus pw hauv tsev kho mob tam sim thiab kev pab yog tsim nyog: iv 50 ml ntawm 20-30% kua qabzib, tom qab ntawd 10% dextrose lossis kua nplaum tov nrog kua. Hauv ob hnub, cov piam thaj hauv qib tau saib xyuas. Kev lim ntshav ua tsis tau zoo.

Kev sib txuam

Concomitant siv nrog Cimetidineuas nce siab gliclazideuas tuaj yeem ua rau mob ntshav qis.

Thaum ua ntawv thov nrog Verapamil koj yuav tsum tswj hwm qhov qib ntawm cov piam thaj.

Cov nyhuv hypoglycemic yog hwj chim thaum siv nrog salicylatesderivatives Pyrazolone, sulfonamides, tshuaj muaj roj, Phenylbutazone, Theophylline.

Kev siv cov tsis-xaiv beta-blockers nce kev pheej hmoo ntshav qog.

Thaum ua ntawv thov Acarbosecim cov nyhuv hypoglycemic ntxiv.

Thaum siv GCS (suav nrog lwm daim ntawv thov sab nrauv), barbiturates, tshuaj kho mob, tshuaj estrogenthiab progestins, Diphenin, Rifampicin lub suab thaj-txo cov nyhuv ntawm cov tshuaj yog txo.

Kev tshuaj xyuas txog Gliclazide

Tam sim no, derivatives muaj ntau siv dav.tiam II sulfonylureas, rau cov uas Gliclazide nyob muaj, vim tias lawv zoo dua rau cov tshuaj ntawm lub cim yav dhau los hauv kev cuam tshuam ntawm cov nyhuv hypoglycemic, vim tias qhov kev sib txuam rau β-cell receptors yog 2-5 zaug siab dua, uas tso cai ua kom ua tiav cov nyhuv thaum sau tshuaj tsawg kawg. Qhov yeeb tshuaj ntawm no tsawg dua yuav ua rau muaj kev phiv tshuaj.

Ib lub cev ntawm cov tshuaj yog tias muaj ntau yam metabolites tau tsim thaum lub sijhawm hloov cov khoom noj hauv lub cev, thiab ib qho ntawm lawv muaj qhov cuam tshuam tseem ceeb ntawm microcirculation. Ntau cov kev tshawb fawb tau pom tias txo qis mob microvascular (retinopathythiab nephropathy) hauv kev kho mob gliclazideCov. Mob heev txo tshuaj mob ntsws, kev txhim kho kev sib txuam txhim kho, ploj leeg vau stasisCov. Tias yog vim li cas nws yog tsim rau kev nyuaj mob ntshav qab zib mellitus (tshuaj mob ntsws, nephropathyThaum pib mob raum tsis ua haujlwm, hais qhia tawm) thiab qhov no tau qhia los ntawm cov neeg mob uas, rau qhov laj thawj no, tau pauv mus rau noj cov tshuaj no.

Ntau qhov tseem ceeb hais tias cov ntsiav tshuaj yuav tsum tau noj tom qab noj tshais, uas muaj cov khoom noj txaus rau hauv lub sijhawm, kev tshaib plab thaum nruab hnub tsis tso cai. Txwv tsis pub, tawm tsam tom qab ntawm kev noj zaub mov hauv lub cev tsawg thiab tom qab ua haujlwm qoj ib ce, kev tsim kho muaj peev xwm ua tau ntshav qogCov. Nrog rau kev ntxhov siab ntawm lub cev, nws yog ib qho tsim nyog yuav tau hloov cov koob tshuaj ntawm cov tshuaj. Tom qab haus dej cawv, qee tus neeg kuj tseem muaj cov ntshav qog ntshav qab zib.

Cov neeg laus yog qhov tshwj xeeb tshaj rau cov tshuaj hypoglycemic, vim tias lawv qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia yog nce. Hauv kev sib txuas no, lawv tau zoo siv cov yeeb tshuaj luv luv (tsis zoo gliclazide).
Cov neeg mob nco ntsoov hauv lawv cov kev tshuaj xyuas qhov yooj yim ntawm kev siv cov tshuaj tso tawm hloov pauv: lawv ua qeeb qeeb thiab sib luag, yog li lawv siv ib hnub ib zaug. Tsis tas li ntawd, nws cov koob tshuaj zoo yog 2 zaug tsawg dua li kev siv ib txwm gliclazide.

Muaj cov ntaub ntawv hais tias tom qab ob peb xyoos (los ntawm 3 mus rau 5 txij thaum pib lub zuj zus), kev tawm tsam tsim kho - txo qis lossis tsis muaj kev txiav txim ntawm cov tshuaj. Hauv cov xwm txheej zoo li no, tus kws kho mob tau xaiv cov kev sib xyaw ntawm lwm cov kab mob hypoglycemic.

Tsuas tshuaj thiab tswj hwm

Nws raug nquahu kom nqos cov ntsiav tshuaj tag nrho thaum noj tshais yam tsis ntxo lossis tsoo. Cov koob tshuaj nyob rau hauv txhua kis yuav tsum tau xaiv ib tus zuj zus, nyob ntawm seb muaj qib ntshav qabzib nyob hauv cov ntshav thiab glycosylated hemoglobin.

Thawj koob tshuaj pom zoo rau cov neeg laus (suav nrog rau cov neeg laus ≥ 65 xyoo) yog 30 mg / hnub. Thaum muaj kev tswjhwm txaus, cov tshuaj ntawm cov tshuaj no tuaj yeem siv rau kev kho kho. Nrog kev tswj tsis tau zoo glycemic, cov tshuaj txhua hnub tuaj yeem raug nce mus rau 60 mg, 90 mg lossis 120 mg. Qhov nce ntxiv koob tshuaj yog muaj peev xwm ua tau tsis yog ntxov tshaj li tom qab 1 lub hlis ntawm txoj kev kho ntawm qhov tau muab tshuaj kho yav tas los. Cov koob tshuaj txhua hnub yog 30-120 mg hauv 1 koob tshuaj. Qhov siab tshaj plaws uas pom zoo rau txhua hnub yog 120 mg. Yog tias koj plam ib lossis ntau dua ntawm cov tshuaj, koj tsis tuaj yeem noj ntau dua nyob rau koob tshuaj ntxiv, koob tshuaj ploj yuav tsum noj nyob rau hnub tom ntej.

Hloov los ntawm kev noj cov tshuaj kho tsis tso cai gliclazide rau gliclazide 30 mg hloov kho-tso cov ntsiav tshuaj: 1 tab. 80 mg li ib txwm tso gliclazide tuaj yeem hloov nrog 1 tab. 30 mg hloov kho tso tawm glyclatone. Thaum hloov mus rau cov neeg mob los ntawm cov tshuaj gliclazide 80 mg rau gliclazide MV 30 mg, nws raug nquahu kom ua tib zoo saib xyuas cov ntshav hauv lub cev.

Ua ke nrog lwm cov tshuaj hypoglycemic: Glyclazide-Borimed MV 30 mg tuaj yeem siv nrog kev sib xyaw nrog biguanidines, alpha-glucosidase inhibitors lossis insulin.

Nrog kev tswj tsis tau glycemic tsis txaus, kev kho tshuaj insulin ntxiv rau yog ua tib zoo saib xyuas kev kho mob.

Kev kho cov koob tshuaj rau cov neeg laus dua 65 xyoo, thiab ntxiv rau cov neeg mob lub raum tsis ua haujlwm me me mus rau mob hnyav, tsis tas yuav ua.

Sab sij huam

Los ntawm lub plab zom mov: dyspepsia (xeev siab, ntuav, raws plab, mob plab, cem quav) - mob hnyav zuj zus nrog zaub mov, tsis tshua muaj - daim siab ua haujlwm (mob siab, mob daj ntseg - yuav tsum tsis siv tshuaj, ntxiv kev ua haujlwm ntawm "mob siab" transaminases, alkaline phosphatase).

Los ntawm cov kabmob hemopoietic: inhibition ntawm cov pob txha mob hematopoiesis (mob ntshav qab zib, thrombocytopenia, leukopenia, granulocytopenia).

Kev ua xua tsis haum: tawv nqaij khaus, urticaria, tawv nqaij ua pob, nrog rau maculopapular thiab bullous), erythema, ua xua vasculitis.

Kev ua ntawm hypoglycemia: kiv taub hau, nkees, tsaug zog, mob taub hau thiab tawm hws, tsis muaj zog, tshee hnyo, tshee hnyo, plab hlaub. Lwm cov tsos mob tshwm sim ntawm tus mob ntshav qab zib: kev tshaib kev nqhis, pw tsaug zog, ntxhov siab, ntxhov siab, tsis meej pem, ua rau muaj kev cuam tshuam qeeb, kev nyuaj siab, tsis meej pem, pom lub cev thiab hais lus tsis meej, kev nyuaj siab, paresis, tsis meej pem, hnov ​​qhov tsis nco qab, ploj ntawm kev tswj yus tus kheej, delirium, cramps, ua pa nyuaj, ua kom nkhaus, tsaug zog thiab tsis nco qab, uas tuaj yeem ua rau tsis nco qab thiab tuag.

Ntxiv rau, cov cim ntawm adrenergic counter-kev cai yuav tsim, xws li tawm hws, tawv nqaij, ntxhov siab, tachycardia, ntshav siab, plawv dhia, lub plawv dhia, lub plawv nres lub plawv thiab lub plawv dhia tsis ua haujlwm. Feem ntau, cov kev kuaj mob no feem ntau ploj tom qab noj cov khoom noj uas muaj carbohydrates (qab zib). Cov khoom qab zib tsim tsis muaj kev cuam tshuam rau kev tso tseg kev mob ntshav qab zib. Cov kev paub ntawm kev siv lwm cov sulfonylurea npaj qhia tau tias yuav muaj kev rov qab los ntawm hypoglycemia tseem nyob rau hauv cov teeb meem no thaum ntsuas tau los tshem tawm nws pib zoo. Hauv kev hnyav thiab tawm tsam kev mob ntshav qab zib tsawg, thiab txawm hais tias nws tuaj yeem raug tshem tawm ib ntus los ntawm kev noj suab thaj, kev kho mob sai sai lossis mus pw hauv tsev kho mob yog qhov tsim nyog.

Pom kev tsis pom kev: Ua rau pom kev txawv txav yog qhov ua tau, tshwj xeeb tshaj yog thaum pib kho, vim muaj kev hloov pauv hauv cov ntshav cov piam thaj.

Los ntawm cov hlab plawv system: mob tawm hauv lub plawv, mob plawv tsis ua haujlwm, myocardial infarction, cerebrovascular tsis txaus, txhaws ntswg, mob hlab ntsha tsis txaus, mob ntshav txhav, mob ceg, mob hauv plab, mob tachycardia, thrombophlebitis.

Daim ntawv thov nta

Nws tsuas yog tuaj yeem tau noj rau cov neeg mob uas noj mov tsis tu ncua thiab suav nrog pluas tshais. Nws yog ib qho tseem ceeb heev uas yuav tsum tswj kom muaj cov roj nplej zom kom ntau txaus nrog cov zaub mov, raws li txoj kev pheej hmoo ntawm kev txhim kho hypoglycemia nce nrog cov teeb meem tsis xwm yeem lossis noj zaub mov tsis zoo, nrog rau kev noj zaub mov tsis muaj carbohydrate-cov zaub mov tsis zoo. Kev mob ntshav qab zib feem ntau pib txhim kho nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua kom ib ce muaj zog, tom qab haus cawv, lossis thaum noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm. Feem ntau, cov tsos mob ntawm hypoglycemia ploj tom qab noj mov uas muaj nplua nuj hauv carbohydrates (xws li qab zib). Nws yuav tsum tau yug hauv siab tias kev noj cov khoom qab zib tsis pab tshem tawm cov tsos mob hypoglycemic. Hypoglycemia tuaj yeem rov tshwm sim dua txawm tias pib kho mob ntawm tus mob no. Yog tias cov tsos mob hypoglycemic muaj cov cim zoo lossis muaj lub siab ntev, txawm tias muaj kev txhim kho ib ntus tom qab noj zaub mov nplua nuj hauv carbohydrates, kev kho mob xwm txheej ceev yog tsim nyog, mus txog tsev kho mob.

Thaum noj cov tshuaj no, kev txiav txim siab tsis tu ncua ntawm cov ntshav txhauv thiab glycosylated Hb yog qhov tsim nyog.

Cov kab mob sib kis nrog cov mob febrile yuav xav tau kev tshem tawm ntawm qhov ncauj hypoglycemic tshuaj thiab kev tswj hwm ntawm insulin.

Cov neeg mob yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib siab ntau thaum muaj kev noj tshuaj ethanol uas muaj tshuaj (nrog rau kev txhim kho disulfiram-zoo li cov tshuaj tiv thaiv: mob plab, xeev siab, ntuav, mob taub hau), NSAIDs, thiab tshaib plab.

Ib qho kev hloov kho koob tshuaj yog qhov tsim nyog rau kev tawm dag zog lub cev thiab lub siab, hloov kev noj zaub mov.

Kev pheej hmoo ntawm kev txhim kho hypoglycemia tau sau tseg hauv cov xwm txheej hauv qab no: tus neeg mob tsis kam lossis tsis muaj peev xwm (tshwj xeeb tshaj yog cov neeg laus) ua raws li kws kho mob tau sau tseg thiab tswj hwm nws tus mob, noj zaub mov tsis txaus thiab tsis txaus noj, hla zaub mov noj, yoo mov thiab hloov pauv kev noj zaub mov, ib qho kev tsis txaus ntawm kev ua haujlwm ntawm lub cev thiab tus nqi ntawm carbohydrates noj, lub raum. tsis txaus ntseeg lossis mob siab daim siab tsis ua haujlwm, kev noj tshuaj ntau dhau ntawm MV gliclazide, qee qhov kev ua rau endocrine (kab mob thyroid, pituitary thiab adrenal tsis txaus).

Hauv cov neeg mob uas muaj mob hepatic thiab / lossis lub raum tsis ua haujlwm, qhov hloov pauv ntawm chaw muag tshuaj thiab / lossis chaw muag tshuaj muaj zog ntawm gliclazide yog ua tau. Kev mob ntshav nce siab uas tsim kho hauv cov neeg mob no tuaj yeem siv sijhawm ntev heev, nyob rau hauv cov xwm txheej zoo li no, yuav tsum tau kho kom sai.

Nws yog qhov yuav tsum tau ceeb toom rau tus neeg mob thiab nws tsev neeg txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib, nws cov tsos mob thiab cov xwm txheej zoo rau nws txoj kev txhim kho. Yuav tsum qhia rau tus neeg mob txog cov kev pheej hmoo thiab cov txiaj ntsig zoo ntawm txoj kev kho mob uas tau thov. Tus neeg mob xav tau qhia meej txog qhov tseem ceeb ntawm kev noj haus, qhov xav tau ua kom lub cev muaj zog thiab soj ntsuam cov ntshav qabzib kom tsis tu ncua.

Thaum lub sijhawm kho mob, yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm yam kev phom sij uas yuav tsum muaj kev mloog zoo thiab ceev ntawm cov kev tiv thaiv psychomotor.

Kev tiv thaiv kev nyab xeeb

Cov neeg laus, tsis meej thiab / los yog tsis muaj zaub mov noj tsis txaus, cov kab mob hnyav ntawm cov hlab plawv (suav nrog rau cov hlab plawv, atherosclerosis), hypothyroidism, adrenal lossis pituitary tsis txaus, hypopituitarism, raum thiab / lossis daim siab tsis ua haujlwm, ntev glucocorticosteroid txoj kev kho, haus dej cawv , glucose-6-phosphate dehydrogenase deficiency, concomitant kho nrog phenylbutazone thiab danazole.

Kev ntshav siab. Gliclazide txoj kev kho tsuas yog kho rau cov neeg mob uas tuaj yeem muab cov pluas noj tsis tu ncua (suav nrog noj tshais).Txoj kev pheej hmoo ntawm cov ntshav qog ntshav qab zib nce ntxiv nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua rau lub cev ntau dhau, haus dej haus cawv, lossis thaum muaj kev sib xyaw ua ke ntawm ntau cov tshuaj hypoglycemic los ntawm pab pawg sulfonylurea.

Tsis muaj mob siab lossis lub raum ua haujlwm. Hauv cov neeg mob no, kev mob ntshav qog ntawm lub cev yuav ua tau ntev dua, uas yuav tsum tau siv coj los ntsuas kom tsim nyog.

Qhov kev ua tau zoo ntawm ib qho tshuaj hypoglycemic hauv qhov ncauj, suav nrog gliclazide, hauv ntau tus neeg mob txo qis lub sijhawm: qhov no yuav yog vim qhov kev vam meej ntawm cov ntshav qab zib lossis cov tshuaj tiv thaiv tsis muaj zog.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv txiav cov tshuaj - siv cov tshuaj uas tsis tu ncua: yuav luag dawb lossis dawb, biconvex, 30 mg thiab 60 mg oval, 90 mg capsule-puab, G90 engraving ntawm ib sab (30 mg: 10 pcs. Hauv cov hlwv) , hauv daim duab los qhia ib pob ntawm 3, 6 lossis 9 hlwv, 15 pcs txhua qhov hauv lub hlwv, hauv ib daim duab los qhwv 2, 4 lossis 6 blisters, 60 mg txhua: 15 pcs hauv ib lub hlwv, hauv ib pob duab los ntawm 2, 4, 6 lossis 8 hlwv , 90 mg: 10 pcs. Hauv qhov qhwv, hauv pob ntawv qhwv ntawm 3, 6 lossis 9 hlwv).

1 ntsiav tshuaj muaj:

• cov tshuaj nquag: gliclazide - 30 mg, 60 mg lossis 90 mg,
• kev zam: hypromellose (100 mPas - nominal viscosity rau 2% aqueous tov), ​​lactose monohydrate, colloidal silicon dioxide, magnesium stearate.

Tsis tas li ntawd, hauv 30 mg ntsiav tshuaj - hypromellose (4000 mPas), calcium carbonate.

Kev ntsuas rau siv

Kev siv Glyclades yog qhia rau kev kho mob ntawm cov neeg laus cov neeg mob ntshav qab zib hom 2 mob ntshav qab zib nrog kev tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo, ua kom lub cev thiab yuag poob.

Ntxiv rau, cov tshuaj yog tawm rau kev tiv thaiv kev tsis sib haum hauv cov neeg mob uas muaj ntshav qab zib hom 2: ua rau muaj kev pheej hmoo ntawm microvascular (retinopathy, nephropathy) thiab macrovascular (myocardial infarction, stroke) cov teeb meem.

Tsuas tshuaj thiab tswj hwm

Cov ntsiav tshuaj tau noj ntawm qhov ncauj thaum noj tshais, 1 zaug hauv ib hnub.

Cov koob tshuaj Glyclades tau sau tseg ib leeg zuj zus raws li theem ntawm glycosylated hemoglobin (HbAlc) thiab kev saib xyuas cov ntshav qabzib siab.

Pom zoo kom noj tshuaj nyob rau txhua hnub: qhov koob tshuaj thawj zaug yog 30 mg, yog tias cov koob tshuaj no tso cai rau koj kom ua tiav cov txiaj ntsig zoo tshaj plaws, nws raug coj los ua txij nkawm. Thaum tsis tas yuav tsum muaj cov kev tswj glycemic, cov koob tshuaj yuav tsum tau maj mam nce ntxiv (coj mus rau hauv tus lej ntawm cov concentration ntawm cov piam thaj hauv cov ntshav) mus rau 60 mg, 90 mg lossis 120 mg rau ib hnub. Yog tias qhov txo qis hauv cov ntshav qab zib cov ntshav tshwm sim nyob hauv ob lub lis piam ntawm kev kho, qhov koob tshuaj yuav raug nce nrog lub sijhawm ntawm 4 lub lis piam lossis ntau dua. Yog tias tom qab ob lub lim tiam ntawm kev siv tshuaj, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav tsis txo qis, qhov koob tshuaj yuav tsum nce ntxiv nyob rau thaum xaus ntawm lub lim tiam thib ob ntawm kev kho mob.

Qhov siab tshaj plaws niaj hnub noj yog 120 mg.

Thaum hloov los ntawm kev noj tam sim ntawd tso cov ntsiav tshuaj uas muaj 80 mg ntawm glyclazide, nws yuav tsum tau yug los rau hauv lub siab tias cov nyhuv ntawm ib qho ntsiav tshuaj no sib npaug rau ib qho 30 mg ntawm Gliclada ntsiav tshuaj. Hloov cov tshuaj yuav tsum nrog nrog ua tib zoo saib xyuas los ntawm kev saib xyuas cov kua nplaum hauv cov ntshav.

Thawj qhov tshuaj thawj zaug ntawm cov tshuaj thaum hloov los ntawm ib qho (txawm tias siab tshaj plaws) koob tshuaj ntawm yav dhau los

hypoglycemic qhov ncauj tshuaj yuav tsum yog 30 mg. Hauv qhov no, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv cov koob tshuaj, qhov ua tau zoo thiab lub sijhawm ua haujlwm ntawm tus neeg sawv cev dhau los.

Yog tias tus neeg sawv cev yav tas los hypoglycemic muaj ib tus ntev T_1/2txhawm rau tiv thaiv tau cov txiaj ntsig ntxiv thiab kev txhim kho hypoglycemia, kev ncua sij hawm ib ntus (ob peb hnub) kev kho mob yog ua tau. Tom qab rov pib kho txoj kev kho mob, nws yog ib qho tsim nyog kom nrog rau 1-2 lub lis piam ua tib zoo saib xyuas tus neeg mob tus mob.

Cov tshuaj yuav siv tau los ua ke nrog biguanides, thiazolidinedione derivatives, alpha-glucosidase inhibitors lossis insulin.

Pib kev kho mob nrog kev siv tshuaj insulin yog qhov tsim nyog nrog kev saib xyuas mob.

Nrog cov mob me thiab mob hnyav ntawm lub raum tsis ua hauj lwm, kev tsim cov vaj tsev huv si (CC) ntawm 15-80 ml / min, kev kho mob ntawm cov neeg mob hnub nyoog tshaj 65 xyoos tsis tas yuav tsum tau txhaj koob tshuaj.

Yuav kom ncav qib siab hauv HbAlc, ntxiv rau cov tshuaj tiv thaiv tsawg zuj zus ntawm qhov tshuaj, nws yog ib qho tsim nyog yuav tsum ua tib zoo noj cov zaub mov tshwj xeeb thiab ua kev tawm dag zog lub cev.

Cov lus qhia tshwj xeeb

Thaum lub sij hawm thov Glyclades, tus neeg mob yuav tsum ua raws li kev noj zaub mov zoo, nco ntsoov suav nrog kev noj tshais, txij thaum noj zaub mov tsis xwm yeem, noj ib pluas mov tsis ntev lossis tsis txaus noj ntau yuav ua rau muaj kev mob ntshav qab zib tsawg. Cov tsos mob ntawm tus mob hypoglycemia: kev tshaib nqhis, mob taub hau, xeev siab, ntuav, ntau zog, kev txhoj puab heev, chim siab, tsis muaj zog, pw tsaug zog, tsaug zog, ntxhov siab, pom kev tsis meej, tsis nco qab lawm, tsis muaj peev xwm mloog zoo, kiv taub hau, ncua tshuaj tiv thaiv, kev nyuaj siab, tshee tshee, qaug cawv, paresis , kev ntxhov siab tsis meej pem, plam ntawm kev tswj tus kheej, ua kom qaug dab peg, ntiab tawm, txhawm rau, ua pa nyuaj, tsis nco qab, tsis nco qab lawm. Ntxiv rau, tus neeg mob yuav muaj kev tawm hws ntau, ntxhov siab, nce ntshav siab, tachycardia, palpitations, angina pectoris, mob plawv dhia tsis meej, txhav thiab tawv nqaij txias.

Txhawm rau cheem hypoglycemic, nws yog ib qho tsim nyog yuav tsum tau noj cov tshuaj carbohydrates (qab zib), hauv kev mob hnyav, yuav tsum tau txais kev kho mob xwm txheej ceev (cov ntshav qabzib nyob hauv ntshav).

Kev siv txoj kev ntsuas tus kheej saib txog qib ntawm cov piam thaj hauv ntshav plasma tso cai rau koj kom sau cov kev hloov pauv ntawm tus neeg mob lub sijhawm.

Kev ua raws li cov tshuaj noj kom nruj - noj cov tshuaj thaum noj tshais - txo qhov ua rau muaj kev pheej hmoo tsis zoo tshwm sim hauv daim ntawv ntawm dyspepsia.

Thaum cov tsos mob ntawm tus mob cholestatic tshwm sim, cov ntsiav tshuaj yuav tsum tau txuas mus ntxiv.

Kev ua raws li kev noj zaub mov kom lub cev tsawg, ua kom lub cev qoj ib ce ntev los sis lub cev ntau dhau, ua ke siv lwm cov tshuaj tiv thaiv hypoglycemic, haus cawv lossis noj ntau dhau ntawm cov tshuaj yuav ua rau muaj kev mob ntshav qab zib tsawg.

Qhov tseeb uas ua rau muaj kev pheej hmoo ntawm hypoglycemia suav nrog kev muaj feem cuam tshuam: kev mob raum tsis ua haujlwm, kev mob siab rau lub siab, kev mob qog, txhaws qog-adrenal tsis txaus, hypopituitarism. Hloov cov khoom ntawm gliclazide nyob rau hauv hepatic lossis lub raum tsis ua haujlwm loj tuaj yeem ua rau tus neeg mob lub cev ntev dua ntawm lub qog ntshav qab zib.

Koj tsis tuaj yeem chim siab qhov sib npaug ntawm qhov ntau ntawm cov carbohydrates noj, qoj ib ce thiab kev ntxhov siab.

Kev siv ntawm lwm cov tshuaj yog contraindicated tsis muaj sab laj nrog kws kho mob.

Kev txo qis ntawm cov nyhuv ntawm qhov ncauj hypoglycemic txoj kev kho yuav tshwm sim nrog febrile syndrome, kev raug mob, kis tus mob, kub hnyiab ntev, thiab kev phais mob. Cov xwm txheej no tuaj yeem ua rau qhov kev xav hloov tus neeg mob mus rau kev kho mob insulin.

Nws yuav tsum tau yug los hauv lub siab tias kev siv cov beta-blockers, reserpine, clonidine, guanethidine tuaj yeem npog qhov chaw kho mob cov tsos mob ntawm tus mob ntshav qab zib tsawg.

Nrog rau kev txo qis hauv kev kho mob tom qab siv sijhawm ntev, tus kws kho mob yuav tsum paub tseeb tias tus neeg mob ua raws li cov lus pom zoo ntawm kev noj tshuaj, kev noj haus thiab kev tawm dag zog. Yog hais tias tus neeg mob ua tib zoo ua raws li lawv, tom qab ntawd qhov txo qis hauv kev tswj hwm glycemic yog vim qhov muaj mob ntawm cov kab mob.

Kev siv cov glycases nyob rau hauv cov ntaub ntawv ntawm cov piam thaj tsis txaus-6-phosphate dehydrogenase tuaj yeem ua rau txoj kev loj hlob ntawm hemolytic anemia.

Hauv lub sijhawm ntawm kev siv tshuaj, nws raug nquahu tias cov neeg mob ntshav qab zib mellitus yuav tsum ceev faj thaum tsav tsheb thiab cov txheej txheem.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib Glyclades:

• miconazole, phenylbutazone, danazole, ethanol ua rau muaj qhov nce hauv hypoglycemic cov tshuaj ntau dua, nce qhov kev pheej hmoo ntawm hypoglycemia, coma,
• cov tshuaj insulin, biguanides, acarbose, beta-blockers, sulfonamides, angiotensin hloov enzyme inhibitors (enalapril, captopril), fluconazole, cimetidine, monoamine oxidase inhibitors, tshuaj tsis-steroidal anti-inflammatory tshuaj, clarithromycin muaj peev xwm
• chlorpromazine hauv siab (ntau tshaj 100 mg rau ib hnub) koob tshuaj nce qib ntawm cov piam thaj hauv cov ntshav, txo cov ntshav insulin,
• tetracosactide, GCS rau kev kaw lus, intraarticular, sab nraud thiab lub qhov quav siv qhov kev pheej hmoo ntawm kev tsim ketoacidosis,
• salbutamol, ritodrin, terbutaline nce ntshav qabzib,
• warfarin thiab lwm yam tshuaj anticoagulants txhim kho lawv cov nyhuv kho kom zoo.

Gliklad's analogues yog: ntsiav tshuaj - Diabeton MV, Gliclazide MV, Diabefarm MV, Glidiab.

Dosage daim ntawv

30 mg thiab 60 mg hloov kho cov ntsiav tshuaj tso tawm

Muaj ib ntsiav tshuaj:

cov tshuaj heev - gliclazide 30.0 mg lossis 60.0 mg,

tus zam: silicon dioxide anhydrous colloidal, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Cov ntsiav tshuaj yog dawb los yog yuav luag dawb hauv cov xim, puag ncig hauv cov duab nrog ib tug cylindrical nto thiab ib tug bevel (rau qhov tsuas tshuaj ntawm 30 mg).

Ntsiav tshuaj yog xim dawb los yog yuav luag xim dawb, puag ncig hauv cov duab nrog ib puag ncig cylindrical, facet thiab nqis siab tshaj (rau qhov ntau npaum ntawm 60 mg).

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, gliclazide yog kiag li nqus los ntawm txoj hnyuv hauv lub plab. Kev noj tsis cuam tshuam rau qib kev nqus. Qhov siab ntawm gliclazide hauv plasma nce ntau zuj zus nyob rau thawj 6 teev tom qab kev tswj hwm thiab nce mus txog toj siab uas tseem pheej ua siab ntev ntev txuas txij 6 mus txog 12 teev. Qhov sib txawv ntawm tus kheej ob leeg yog qhov tsawg. Cov kev sib raug zoo ntawm cov koob tshuaj kom txog li 120 mg thiab lub plasma concentration nkhaus ntawm cov tshuaj yog qhov tso sij hawm tso siab. Kwv yees li 95% ntawm cov tshuaj khi rau cov ntshav plasma.

Gliclazide metabolized feem ntau yog nyob hauv daim siab thiab ua rau feem ntau tso zis. Kev nqhis dej yog nqa tawm feem ntau los ntawm lub raum hauv daim ntawv ntawm cov tshuaj ua kom muaj zog, tsawg dua 1% yog pom tawm tsis hloov hauv cov zis. Tsis muaj cov metabolites hauv lub plasma ntshav.

Ib nrab-lub neej (T1 / 2) ntawm gliclazide ntsuas thaj tsam 16 teev (12 txog 20 teev).

Hauv cov neeg laus, tsis muaj kev hloov pauv ntau hauv cov qauv pharmacokinetic.

Ib koob tshuaj txhua hnub ntawm 60 mg muab qhov kev txiav txim zoo ntawm gliclazide hauv plasma rau ntau tshaj 24 teev.

Cov Tshuaj Hauv Tshuaj

Gliclazide MV yog qhov ncauj tshuaj hypoglycemic los ntawm cov pab pawg ntawm II tiam sulfonylurea derivatives, uas txawv ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic ntiv nplhaib nrog kev ua kom sib luag endocyclic.

Gliclazide MB txo qib ntawm cov piam thaj hauv cov ntshav, txhawb lub zais ntshav ntawm insulin los ntawm β-hlwb ntawm islets ntawm Langerhans. Tom qab 2 xyoo ntawm kev kho mob, feem ntau cov neeg mob tseem muaj qhov nce ntawm theem ntawm cov tshuaj insulin tom qab thiab kev zais C-peptides.

Hauv hom 2 mob ntshav qab zib mellitus, cov tshuaj rov qab ua rau lub sijhawm thaum kawg ntawm cov kua dej hauv cov kua dej hauv cov lus teb rau cov piam thaj thiab ua rau qib thib ob ntawm insulin zais cia. Ib qho tseem ceeb nce ntxiv ntawm insulin secretion tau pom nyob rau hauv teb rau kev tsa ua vim kev noj zaub mov thiab qabzib kev tswj hwm.

Gliclazide MV muaj qhov cuam tshuam rau microcirculation. Nws txo txoj kev pheej hmoo ntawm cov ntshav me me kom tsis muaj teeb meem, muaj kev cuam tshuam rau ob lub tswv yim uas yuav koom nrog kev txhim kho ntawm kev mob ntshav qab zib mellitus: ib feem ntawm kev ua kom tsis muaj platelet thiab kev ua kom tiav thiab ib qho kev poob qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B2), nrog rau kev rov ua haujlwm ntawm fibrinolytic vascular endothelium thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Cov tshuaj sib cuam tshuam

Cov tshuaj uas txhim kho cov nyhuv ntawm Gliclazide MV (muaj kev pheej hmoo ntawm hypoglycemia)

Miconazole (thaum muab kev tswj hwm los ntawm txheej txheem lossis siv rau lub qhov ncauj ntawm qhov ncauj ua ib hom gel): txhim kho qhov kev tiv thaiv hypoglycemic ntawm MV Gliclazide (hypoglycemia yuav loj hlob mus txog hypoglycemic coma).

Tsis pom zoo rau kev siv:

Phenylbutazone txhim kho cov nyhuv hypoglycemic ntawm sulfonylurea derivatives (hloov chaw rau lawv los ntawm kev sib txuas lus nrog plasma protein thiab / lossis qeeb qee qhov kev txiav tawm ntawm lub cev).

Nws zoo dua yog siv lwm cov tshuaj tiv thaiv kev tiv thaiv.

Cawv yuav pab txo cov ntshav qab zib kom tsawg, tiv thaiv kev tiv thaiv tsis taus, tuaj yeem pab txhawb kev txhim kho hypoglycemic coma.

Nws yog ib qho tsim nyog yuav tsum tso tseg txoj kev haus cawv thiab siv tshuaj, uas suav nrog cawv.

Kev sib txuas ua ke xav tau ceev faj:

Kev siv ib txhij ntawm cov tshuaj hauv qab no tuaj yeem ua rau lub ntsej muag hypoglycemic ntawm cov tshuaj Gliclazide MV thiab qee kis ua rau pib ntawm hypoglycemia:

lwm cov tshuaj tiv thaiv kab mob (insulins, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-hloov enzyme inhibitors (captopril, enalapril), H2 receptor antagonists, irreversible monoamine oxidase inhibitors (MAO I), sulfonamides thiab tshuaj tsis-steroidal tshuaj tiv thaiv.

Glyclazide MV-ua kom qaug tshuaj

Tsis pom zoo rau kev siv:

Kev siv yooj yim nrog Danazol tsis pom zoo vim qhov kev pheej hmoo ntawm kev nce ntxiv hauv cov ntshav qabzib. Yog tias nws tsis tuaj yeem tsis lees paub txog kev siv danazol, tom qab ntawd piav qhia rau tus neeg mob txog qhov tseem ceeb ntawm kev tswj hwm qhov concentration ntawm cov piam thaj hauv cov ntshav thiab zis. Qee lub sij hawm nws yuav tsum kho qhov koob tshuaj ntawm Gliclazide MV lub sijhawm thiab tom qab kev kho mob danazol.

Kev sib txuas ua ke xav tau ceev faj:

Chlorpromazine hauv kev txhaj tshuaj ntau (ntau tshaj 100 mg rau ib hnub) nce qib ntawm cov piam thaj hauv cov ntshav, txo qis cov ntshav ntawm insulin.

Glucocorticosteroids (muaj daim ntawv thov rau hauv ib cheeb tsam thiab thaj chaw: thaj tsam hauv daim tawv nqaij, lub cev nqaij daim tawv thiab qhov quav) thiab tetracosactrin ua rau muaj ntshav qabzib nrog kev txhim kho ketoacidosis, vim tias kev txo qis hauv kev ua kom tsis haum xeeb los ntawm glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (kev siv lub cev) ua rau muaj cov piam thaj ntau ntxiv.

Ua tib zoo saib xyuas qhov tseem ceeb ntawm kev saib xyuas tus kheej ntawm cov piam thaj hauv ntshav. Yog tias tsim nyog, hloov tus neeg mob mus rau kev kho mob insulin.

Yog tias koj yuav tsum siv cov kev sib txuas ua ke saum toj saud, koj yuav tsum tau them nyiaj tshwj xeeb los tswj cov ntshav qabzib hauv cov ntshav. Nws yuav tsim nyog los ntxiv kho qhov koob tshuaj ntawm MV Glyclazide ob leeg thaum sib koom ua ke kho thiab tom qab tsum tsis siv tshuaj ntxiv.

Kev sib koom tes ntawm Gliclazide MV nrog cov tshuaj tiv thaiv anticoagulant (warfarin, thiab lwm yam) tuaj yeem ua rau cov tshuaj anticoagulant nce ntxiv ntawm cov tshuaj no. Cov tshuaj tiv thaiv Anticoagulant yuav tsum tau kho kom haum.

Cov ntaub ntawv dav dav

Cov ntawv pov thawj rau npe Gliclazide MV yog tawm los ntawm tuam txhab Lavxias Atoll LLC. Cov tshuaj yeeb yaj kiab hauv qab ntawv cog lus yog tsim los ntawm Samara lub tuam txhab tshuaj Ozone. Nws ua thiab ntim cov ntsiav tshuaj, thiab tswj lawv qhov zoo. Gliclazide MV tsis tuaj yeem hu ua cov tshuaj hauv tsev, vim tias cov tshuaj yeeb tshuaj rau nws (tib yam glyclazide) tau yuav hauv Suav teb. Dua li ntawm qhov no, tsis muaj dab tsi tsis zoo tuaj yeem hais txog qhov zoo ntawm cov tshuaj. Raws li cov kws kho mob ntshav qab zib, nws tsis muaj qhov phem tshaj li Fab Kis Diabeton nrog tib yam.

Cov kab lus ncua hauv MV nyob rau hauv lub npe ntawm cov tshuaj qhia tau hais tias cov tshuaj nquag hauv nws yog hloov kho, lossis ntev ntev, tso tawm. Glyclazide tawm cov ntsiav tshuaj thaum lub sijhawm thiab hauv qhov chaw zoo, uas ua kom paub meej tias nws tsis nkag mus rau hauv cov hlab ntshav tam sim ntawd, tab sis hauv feem me me. Vim tias qhov no, qhov kev pheej hmoo ntawm qhov tsis tsim nyog raug txo qis, cov tshuaj muaj peev xwm coj tau tsawg dua.Yog tias tus qauv ntawm cov ntsiav tshuaj raug yuam, nws txoj haujlwm ntev yog ploj, yog li ntawd, cov lus qhia rau kev siv tsis pom zoo kom ntov nws.

Glyclazide muaj nyob hauv cov npe tshuaj tseem ceeb, yog li cov kws kho mob endocrinologist muaj lub sijhawm los sau nws rau cov ntshav qab zib pub dawb. Feem ntau cov feem ntau, raws li daim ntawv sau tshuaj, nws yog qhov kev nyeg MV Gliclazide uas yog ib qho piv txwv ntawm cov Diabeton qub.

Cov tshuaj ua haujlwm li cas?

Txhua tus gliclazide daig nyob rau hauv cov hnyuv tau nqus rau hauv cov ntshav thiab muaj qhov khi rau nws cov protein. Feem ntau, cov piam thaj nkag mus hauv beta hlwb thiab txhawb cov neeg tshwj xeeb uas ua rau muaj qhov tso tawm ntawm cov kua dej. Glyclazide ua haujlwm los ntawm tib lub hauv paus ntsiab lus, artificially provoking lub synthesis ntawm yam tshuaj.

Cov nyhuv ntawm cov kua dej hauv kev tsim tawm tsis tas rau cov nyhuv ntawm MV Glyclazide. Cov tshuaj muaj peev xwm ntawm:

1. Txo cov tshuaj tiv thaiv insulin. Cov txiaj ntsig zoo tshaj plaws (nce insulin rhiab heev los ntawm 35%) raug pom hauv cov leeg nqaij.
2. Txo cov synthesis ntawm cov piam thaj los ntawm lub siab, yog li ntawd ib txwm ua rau nws qib sai.
3. Tiv thaiv kom ntshav txhaws.
4. Pab txhawb ua ke ntawm cov tshuaj nitric oxide, uas koom nrog tswj kev kub siab, txo kev mob, thiab txhim kho cov ntshav rau cov ntaub so ntswg.
5. Ua haujlwm li tshuaj tiv thaiv kab mob.

Daim ntawv tso tawm thiab ntau npaum li cas

Hauv cov ntsiav tshuaj Gliclazide MV yog 30 lossis 60 mg ntawm cov tshuaj nquag. Cov khoom xyaw pabcuam yog: cellulose, uas yog siv los ua tus neeg saib xyuas bulking, silica thiab magnesium stearate li emulsifiers. Cov ntsiav tshuaj ntawm cov xim dawb lossis qab zib, tso rau hauv hlwv ntawm 10-30 pieces. Hauv ib pob ntawm 2-3 blisters (30 lossis 60 ntsiav tshuaj) thiab cov lus qhia. Glyclazide MV 60 mg tuaj yeem faib ua ib nrab, rau qhov no muaj kev pheej hmoo ntawm cov ntsiav tshuaj.

Cov tshuaj yuav tsum haus cawv thaum noj tshaisCov. Gliclazide ua haujlwm txawm hais tias muaj suab thaj hauv cov ntshav. Yog li hais tias hypoglycemia tsis tshwm sim, tsis muaj zaub mov noj yuav tsum raug hla, txhua ntawm lawv yuav tsum muaj kwv yees li ntawm cov nyiaj carbohydrates. Nws raug nquahu kom noj txog li 6 zaug hauv ib hnub.

Cov cai xaiv:

Cov lus qhia ntxaws ntxiv rau siv

Raws li kev pom zoo hauv chaw kho mob pom zoo los ntawm Ministry of Health ntawm Lavxias Federation, gliclazide yuav tsum tau sau tseg los siv tshuaj insulin secretion. Qhov kev xav, qhov tsis muaj ntawm ib tus kheej lawm yuav tsum tau paub tseeb los ntawm kev kuaj mob ntawm tus neeg mob. Raws li kev txheeb xyuas, qhov no tsis tas yuav tshwm sim. Cov kws kho mob thiab cov kws txawj endocrinologists muab tshuaj "los ntawm qhov muag". Raws li qhov tshwm sim, ntau tshaj qhov xav tau ntawm cov tshuaj insulin yog qhov zais cia, tus neeg mob ib txwm xav noj, nws qhov hnyav nce zuj zus, thiab cov nyiaj them rau ntshav qab zib tseem tsis txaus. Tsis tas li ntawd, beta hlwb nrog hom kev ua haujlwm no raug rhuav tshem nrawm dua, uas txhais tau hais tias tus kabmob mus rau theem tom ntej.

Yuav ua li cas zam kom dhau qhov kev rau txim:

1. Pib nruj me ntsis cov kab mob rau cov pluas noj rau cov neeg mob ntshav qab zib (cov lus 9. Cov nyiaj uas tau txais los ntawm carbohydrates yog txiav txim los ntawm tus kws kho mob lossis tus neeg mob nws tus kheej raws li glycemia).
2. Tshaj tawm cov kev nquag hauv kev ua txhua hnub.
3. Qhov hnyav ua rau qhov qub. Rog dhau heev lawm ua rau cov ntshav qab zib.
4. Haus dej qab zib lossis nws cov tshuaj noj. Cov tshuaj noj zoo yog 2000 mg.

Thiab tsuas yog yog hais tias cov kev ntsuas no tsis txaus rau ib txwm qab zib, koj tuaj yeem xav txog gliclazide. Ua ntej pib txoj kev kho mob, nws tsim nyog ntsuas kev soj ntsuam rau C-peptide lossis insulin kom paub tseeb tias qhov sib xyaw ntawm cov tshuaj hormones yog qhov tiag tiag.

Thaum glycated hemoglobin siab dua 8.5%, MV Gliclazide tuaj yeem muab nrog rau kev noj haus thiab metformin ib ntus, kom txog thaum mob ntshav qab zib tau them rov qab. Tom qab ntawd, qhov teeb meem ntawm kev tshem tawm cov tshuaj yog tus kheej tau txiav txim siab.

Daim Ntawv Tso Npe Sau Npe

JLLC "Lekpharm", Koom pheej ntawm Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / fax: +375 1774 53 801, e-mail: [email protected]

Chaw nyob ntawm lub koom haum lees txais kev thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo hauv thaj chaw ntawm cov koom pheej ntawm Kazakhstan

Tus Sawv Cev Chaw Haujlwm ntawm Lekpharm COOO hauv Republican

050065, Koom pheej ntawm Kazakhstan, Almaty, Almaly koog tsev kawm ntawv, ul. Kazybek bi, d. 68/70, kaum ntawm st. Nauryzbay batyr, tel. 8 (727) -2676670, fax 8 (727) -2721178

Lub npe, chaw nyob thiab cov ntsiab lus sib cuag (xov tooj, fev, e-mail) ntawm lub koom haum hauv koom pheej ntawm Kazakhstan kev lav phib xaub rau kev sau npe tom qab kev soj ntsuam xyuas kev nyab xeeb tshuaj

Tus Sawv Cev Chaw Haujlwm ntawm Lekpharm COOO hauv Republican

050065, Koom pheej ntawm Kazakhstan, Almaty, Almaly koog tsev kawm ntawv, ul. Kazybek bi, d. 68/70, kaum ntawm st. Nauryzbay batyr, tel. 8 (727) -2676670, fax 8 (727) -2721178,

Pharmacological kev txiav txim

Xuas thiab faib khoom

Tom qab noj cov tshuaj hauv, gliclazide yog kiag li nqus los ntawm txoj hnyuv hauv plab. Qhov siab ntawm gliclazide hauv plasma nce ntau zuj zus nyob rau thawj 6 teev tom qab kev tswj hwm thiab nce mus txog toj siab uas tseem pheej ua siab ntev ntev txuas txij 6 mus txog 12 teev. Kev hloov pauv ntawm tus kheej muaj feem tsawg. Kev noj tsis cuam tshuam rau qib kev nqus. Qhov xa tawm yog kwv yees li 30 litres. Plasma protein khi yog kwv yees li 95%. Ib qho tshuaj txhua hnub ntawm cov tshuaj Gliclada® ua rau kev saib xyuas ntawm kev saib xyuas zoo ntawm glyclazide hauv cov ntshav ntshav rau ntau dua 24 teev.

Gliclazide yog metabolized feem ntau hauv lub siab. Qhov ua rau lub cev zom tau tsis muaj tshuaj lom neeg kev ua si. Cov kev sib raug zoo ntawm cov koob tshuaj tau nce mus txog 120 mg thiab qhov tsom ntawm cov tshuaj hauv ntshav yog ib txoj kab tso siab raws lub sijhawm.

Ib nrab-lub neej (T1 / 2) ntawm gliclazide yog 12-20 teev. Nws yog tsuas yog tawm los ntawm lub raum hauv daim ntawv ntawm metabolites, tsawg dua 1% yog tawm hauv cov zis tsis hloov pauv.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv cov neeg laus, tsis muaj qhov sib txawv hauv tsev kho mob tau tshawb pom.

Gliclada® yog qhov ncauj tshuaj hypoglycemic los ntawm cov pab pawg ntawm sulfonylurea derivatives ntawm lub cim thib ob, uas sib txawv los ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic nplhaib nrog endocyclic daim ntawv cog lus.

Glyclada ers txo qis ntshav qab zib los ntawm kev ua kom muaj zog hauv insulin secretion los ntawm Langerhans islets nrog R cell. Tom qab ob xyoos ntawm kev kho mob, qhov nce ntawm qib ntawm insulin tom qab thiab kev zais ntsiag to ntawm C-peptides tseem nyob. Hauv hom 2 mob ntshav qab zib mellitus, cov tshuaj rov qab ua rau lub sijhawm thaum kawg ntawm cov kua dej hauv cov kua dej hauv cov lus teb rau cov piam thaj thiab ua rau qib thib ob ntawm insulin zais cia. Ib qho tseem ceeb nce ntxiv ntawm insulin secretion tau pom nyob rau hauv teb rau kev tsa ua vim kev noj zaub mov thiab qabzib kev tswj hwm.

Ntxiv rau kev cuam tshuam rau cov metabolism hauv cov metabolism, Glyclada® muaj qhov cuam tshuam rau microcirculation. Cov tshuaj txo txoj kev pheej hmoo ntawm cov hlab ntsha me me, cuam tshuam rau ob lub tswv yim uas yuav koom nrog kev txhim kho cov teeb meem hauv cov ntshav qab zib mellitus: ib feem ntawm kev txwv tsis pub platelet thiab kev sib dhos thiab ib qho kev txo qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B2), nrog rau kev kho rov qab ntawm fibrinolytic vascular endothelial kev ua si thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Yuav noj li cas thaum cev xeeb tub

Cov lus qhia rau kev siv txwv tsis pub kho nrog Gliclazide thaum cev xeeb tub thiab lactation. Raws li FDA kev faib tawm, cov tshuaj yog rau cov chav kawm C. Qhov no txhais tau tias nws tuaj yeem cuam tshuam tsis zoo rau kev loj hlob ntawm tus me nyuam hauv plab, tab sis tsis ua rau muaj qhov tsis zoo thaum yug los. Gliclazide muaj kev nyab xeeb dua los hloov nrog cov tshuaj insulin ua ntej cev xeeb tub, hauv cov xwm txheej hnyav - thaum pib.

Qhov tau los ntawm kev pub mis niam nrog gliclazide tsis tau sim. Muaj pov thawj tias sulfonylurea kev npaj tau tuaj yeem mus rau hauv cov mis thiab ua rau cov ntshav qab zib hauv cov menyuam mos, yog li lawv qhov kev siv thaum lub sijhawm no raug txwv tsis pub siv.

Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva

Kuv tau kawm qhov teeb meem mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.

Kuv maj nrawm los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov mob ntshav qab zib mellitus kom zoo. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.

Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib kom txog thaum lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!

Phiv thiab haus tshaj

Cov kev mob tshwm sim hnyav tshaj plaws ntawm MV Glyclazide yog hypoglycemia. Nws tshwm sim thaum cov tshuaj insulin ntau dua qhov xav tau nws. Qhov laj thawj yuav yog kev siv tshuaj lom neeg tsis txaus siab rau kev haus cawv, hla zaub mov lossis tsis muaj carbohydrates hauv nws, thiab txawm tias lub cev dhau los. Tsis tas li, ib qho kev poob qis hauv qab zib tuaj yeem ua rau muaj kev cuam tshuam ntawm gliclazide hauv cov ntshav vim yog lub raum thiab daim siab ua haujlwm, qhov nce ntawm cov dej num ntawm insulin hauv qee cov kab mob endocrine. Raws li kev txheeb xyuas, hauv kev kho mob sulfonylureas nrog cov ntshav qab zib, yuav luag txhua tus neeg mob ntshav qab zib lub ntsej muag. Feem ntau cov kua qab zib muaj peev xwm tshem tawm ntawm ib qho yooj yim theem.

Raws li txoj cai, hypoglycemia yog nrog cov yam ntxwv ntawm tus kheej: muaj kev tshaib plab loj, tshee tshee ntawm qhov kawg, ntxhov siab, tsis muaj zog. Qee tus neeg mob maj mam tu tag mus hnov ​​cov tsos mob no, lawv cov piam thaj hauv dej yuav tas sim neej. Lawv xav tau tswj cov piam thaj ntau zaus, suav nrog thaum tsaus ntuj, lossis hloov mus rau lwm cov ntsiav tshuaj uas muaj piam thaj uas tsis muaj qhov tshwm sim li no.

Kev pheej hmoo ntawm lwm cov kev ua tsis tau ntawm Gliclazide raug soj ntsuam ua qhov tsis tshua muaj thiab tsis tshua muaj nqi. Tau:

• teeb meem teeb meem hauv daim ntawv ntawm xeev siab, ua haujlwm nyuaj ua haujlwm, lossis zawv plab. Koj tuaj yeem txo lawv los ntawm kev noj Glyclazide thaum noj mov feem ntau,
• ua xua ntawm daim tawv, feem ntau yog ua pob liab nrog khaus,
• txo qis hauv cov qe ntshav, ntshav liab, ntshav dawb. Cov ntshav sib xyaw ua kom rov zoo li qub rau nws tus kheej tom qab tshem tawm ntawm Gliclazide,
• kev nce ntxiv ib ntus hauv cov kev ua ntawm daim siab enzymes.

Rau leej twg Glyclazide MV yog contraindicated

Dab tsi tuaj yeem hloov tau

Lavxias teb sab gliclazide yog qhov pheej yig, tab sis zoo tshuaj, tus nqi ntawm ntim ntawm Gliclazide MV (30 mg, 60 daim) yog txog 150 rubles. Hloov nws nrog analogues yog tsuas yog tias cov ntsiav tshuaj li ib txwm tsis tau muag.

Tus tshuaj yog Diabeton MV, txhua lwm yam tshuaj nrog tib yam muaj pes tsawg leeg, suav nrog Gliclazide MV yog cov tshuaj generics, lossis luam tawm. Tus nqi ntawm Diabeton yog kwv yees li 2-3 zaug siab dua li nws cov generics.

Glyclazide MV analogues thiab hloov pauv ua npe rau hauv Lavxias Federation (tsuas yog hloov kho tau npaj los qhia tau tias muaj):

• Glyclazide-SZ uas ua los ntawm Severnaya Zvezda CJSC,
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon los ntawm Canonpharm Ntau Lawm,
• Glyclazide MV Tus Kws Kho Mob, Pharmstandard-Tomskkhimfarm,
• Diabetalong, chaw tsim tshuaj paus ntawm MS-Vita,
• Gliklada, Krka,
• Glidiab MV los ntawm Akrikhin,
• Diabefarm MV Cov Tshuaj Ntau Lawm.

Tus nqi ntawm analogues yog 120-150 rubles rau ib pob. Gliklada ua nyob rau hauv Slovenia yog cov tshuaj kim tshaj plaws los ntawm daim ntawv no, pob ntawv raug nqi txog 250 rubles.

Kev Ntsuas Xyuas Mob Ntshav Qab Zib

Kuv nyeem tias Galvus muab qhov txiaj ntsig zoo ib yam, tab sis nws muaj kev nyab xeeb dua yog hais txog cov piam thaj poob hauv qab zib. Kuv yuav nug tus kws kho mob los hloov lawv nrog Gliclazide.

Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv nws. nyeem ntxiv >>