Xyuas txog cov tshuaj Crestor
| ntsiav tshuaj | 10 mg | 28 Pcs. | 1950.9 rub |
| 10 mg | 98 pcs. | ≈ 5365.1 rubles | |
| 20 mg | 28 Pcs. | 4416,5 rub. | |
| 40 mg | 28 Pcs. | ≈ 5890 rub. | |
| 5 mg | 28 Pcs. | ≈ 2123 rub. | |
| 5 mg | 98 pcs. | ≈ 5595 rub. |
Cov kws kho mob rov tshuaj xyuas txog tus ntoo khaub lig
| Ntsuam xyuas 1.3 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Ib qho ntawm cov txiaj ntsig zoo tshaj plaws.
Hepatotoxicity. Ntawd yog, nrog txoj kev muaj txiaj ntsig, peb tau lees tias muaj kev puas tsuaj.
Txij li xyoo 70, txoj cai tswjfwm ntaub ntawv tau muab coj los siv hauv Tebchaws Meskas kom ua lub neej ncaj ncees rau cov neeg Asmeskas. Yog li, cov neeg laus pensioners hnub no qhuab qhia coj ALT thiab AST txhua 3 lub hlis yog tias lawv siv statins. Hmoov tsis zoo, peb tsis muaj qhov kev txiav txim zoo li ntawd.
| Ntsuam xyuas 3.3 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
"Crestor" yog ib qho ntawm thawj cov statins, lub hom phiaj uas yuav tsum tau muab los xav thaum sib txuas erectile kawg nrog dyslipidemia. Tsis yog qhov tsis zoo normalizes lipid profile. Nrog cov khoom sib txuam ua ke, thawj cov txiaj ntsig zoo hauv kev hais txog qib erectile kawg pom txog tom qab 2-3 lub hlis ntawm kev nquag. Cov koob tshuaj yog xaiv ib tus zuj zus, raws li daim lipid profile. Yuav tsum tau muab cov tshuaj antioxidants.
Cov tshuaj yog kim, tab sis thaj, Krestor nws muaj nqis. Muaj peev xwm ua rau muaj kev cuam tshuam ntawm daim siab ua haujlwm.
| Ntsuam Xyuas 4.2 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Nws yeej pab, theem ntawm LDL tsawg dua, nws yog qhov zoo tsuas yog nrog chav kawm thaum kawg, yog li koj yuav tsum tsis txhob tsum tsis noj cov tshuaj tom qab txaus siab kho qhov ua tau tiav.
Qhov ua tib zoo xav tshuaj ntawm cov tshuaj ua rau nws yooj yim thiab yooj yim los tswj cov ntshav hauv cov ntshav siab.
| Ntsuam Xyuas 4.6 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Nyiam statin. Yog, Nyob zoo, tab sis rau qhov laj thawj. Tus thawj tshuaj, i.e. tshawb fawb zoo. Kev ua tau zoo yog qhov ua tau zoo, lipid txo tau tuaj yeem thiab yuav tsum tau xav pom. Tsis txhob tsis saib xyuas kev tswj ntawm daim siab enzymes thaum noj "Crestor" lossis lwm yam statin. Zoo, thiab, ntawm chav kawm, tsis txhob hnov qab tias kev noj haus statin yuav tsum yog, nrog kev zam tsawg, nyob ruaj khov, thiab tsis yog.
| Ntsuam xyuas 2.9 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Tus thawj tshuaj, rosuvastastine. Nws txo qis cov roj (cholesterol) zoo. Ua pov thawj kev ua tau zoo rau qhov kev tiv thaiv ntawm cov mob plawv thib ib.
Cov tshuaj kim heev, tsis yog txhua tus neeg tuaj yeem them taus.
Thaum nkag mus, tswj cov lipid profile thiab ALT, AST yog qhov tsim nyog. Nws noj 1 zaug nyob rau ib hnub, thaum yav tsaus ntuj.
| Ntsuam xyuas 3.8 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Krestor yog qhov tshuaj zoo heev ntawm txhua tus statins. Nrog pov thawj puag. Tom qab 1.5-2 lub hlis ntawm kev siv tas li, cov txiaj ntsig tau pom. Nws yog tshuaj 1 zaug nyob rau ib hnub, txoj kev xaiv tau xaiv ib tus zuj zus, thaum noj cov tshuaj, tswj cov ntshav lipid spectrum, ALT, AST.
Tus nqi ntau dhau, tsis yog txhua tus neeg mob muaj.
Cov tshuaj tau zoo txaus, Kuv pom zoo nws rau kuv cov neeg mob.
| Ntsuam xyuas 3.3 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Tau 2 lub hlis, cov neeg ua kevcai rau dej tsis raug tsa, tshwj xeeb, "txhawm rau txhawm rau tiv thaiv kev txhim kho cov quav hniav." Krestor pom tias muaj peev xwm txo cov quav hniav loj dua tsuas yog tom qab 2 xyoo ntawm kev tswj hwm ntawm ib koob ntawm 40 mg rau ib hnub. Feem ntau, yog tias peev nyiaj txiag tso cai, tsis muaj ib yam dab tsi zoo dua li cov tshuaj qub. Thiab tus thawj rosuvastatin yog Krestor. Tab sis yog tias lo lus nug yog: txawm tias yuav tsum tsis txhob kho txhua, los yog kom coj cov txiaj ntsig zoo, tom qab ntawd, tau kawg, kev ntsuas tus nqi zoo dua yog qhov zoo dua. Nws yog tsim nyog kom nco ntsoov tias txhua yam kev mob tshwm sim mus ntev ntawm rosuvastatin - ib qho kev txo qis hauv lub neej no, qhov tshwm sim ntawm myocardial infarction thiab mob stroke - tau qhia tshwj xeeb rau Crestor, vim tias qhov seem ntawm cov generics tsis tau kawm txog txoj kev no. Txawm hais tias, ntawm chav kawm, qhov tsis muaj txiaj ntsig zoo yuav tsum ua rau muaj kev sib piv hauv cov cholesterol hauv cov ntshav, thiab qhov no yuav tsum muaj pov thawj hauv cov kev tshawb fawb cuam tshuam.
Qhov tsuas yog drawback yog tus nqi. Tshwj xeeb yog tam sim no, tom qab kev hloov pauv ntawm cov kev txauv pauv. Leej twg yuav them taus - cia nws yuav. Koj yuav tsum nco ntsoov tias kev kho mob nrog rau ib qho statin tsis tau ua kom txo qis cov roj cholesterol, tab sis kom txo qis kev pheej hmoo ntawm myocardial infarction, ischemic stroke thiab tuag los ntawm lub plawv mob. Tias yog vim li cas statins yuav tsum coj mus rau xyoo. Thaum ntawd koj yuav raug tso siab rau tiv thaiv koj tej teeb meem uas tau hais los saum no. Yog tias tus ntoo khaub lig zoo rau koj, ces nws yog qhov zoo dua los pib ua qhov ua tau zoo tam sim ntawd. Vim tias yuav tsis pom qhov txiaj ntsig zoo los ntawm kev noj nws hauv ib-ob - peb hlis. Cov roj (cholesterol) yuav ua tsis tau kiag li, tab sis, los ntawm thiab loj, statins tau noj kom tsis txhob txo cov roj cholesterol, tab sis kom txo qis kev pheej hmoo ntawm teeb meem nyob rau hauv daim ntawv ntawm myocardial infarction, mob stroke, thiab lwm yam. Thiab qhov kev pheej hmoo no, raws li txoj cai, pib txo qis nkaus xwb tom qab ntau lub hlis txij li pib noj cov tshuaj statins.
Yog tias muaj kev mob tshwm sim hauv ib tus neeg mob, qhov no tsis txhais tau tias txhua yam yuav tshwm sim rau txhua tus. Yog li, tau mloog ib tus neeg uas tau txais tus ntoo khaub lig (lossis lwm yam) thiab tau txais qhov kev xav tsis txaus ntseeg, tsis muaj ib qhov hais txog qhov no coj mus rau koj tus kheej cov nyiaj. Feem ntau tsis tuaj yeem kwv yees tau tshwm sim ntawm cov kev mob tshwm sim hauv ib tus neeg mob. Koj tsuas yog yuav tsum to taub tias nws tsim nyog raug kho nrog tus ntoo khaub lig thaum koj tuaj yeem them nws rau xyoo. Txwv tsis pub, tam sim ntawd yuav qhov khoom muaj txiaj ntsig zoo thiab kho nrog nws (piv txwv li, mertenyl, lossis roxer, lossis tevastor).
| Ntsuam Xyuas 4.2 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Cov tshuaj zoo tshaj plaws ntawm txhua tus statins. Sai sai cov tshuaj tiv thaiv cov kab mob ntshav mus txog qib. Tsis zoo li analogues, kev kho mob nyhuv txawm tias nyob ntawm koob tshuaj qis.
Tus nqi, ntawm chav kawm, yog qhov loj! Tsis muaj kev sib cav. Tsis yog txhua tus tuaj yeem them nws.
Tus thawj tshuaj. Cov ntaub ntawv pov thawj zoo zoo nkauj. Tab sis tus nqi scares feem coob ntawm cov neeg mob uas xav tau nws.
| Ntsuam xyuas 3.3 / 5 |
| Txij nkawm |
| Nqe / zoo |
| Sab sij huam |
Nws sai sai cov qib roj cholesterol (hauv ib lub lis piam nws tuaj yeem txo cov cim taw qhia kom ib txwm).
Cov tshuaj tau zoo kawm, nrog cov pov thawj loj, lub cev zoo. Ua tau zoo nyob rau hauv cov koob tshuaj me me piv rau lwm cov tshuaj hauv pawg no. Zoo zam txim tau. Feem ntau, nws raug coj txuas mus tas li.
Tus neeg mob tshuaj xyuas txog ntawm tus ntoo khaub lig
Kuv coj Krestor tau 2 lub lis piam, kuv cov leeg ko taw pib mob, Kuv tsis tuaj yeem tsaug zog, Kuv tau noj tshuaj pleev ib ce, ib lis piam dhau mus. Tom qab tshem tawm ntawm qhov mob, tseem muaj qhov mob siab me me ntawm cov leeg thiab cov tawv nqaij thaum kov, Kuv yuav tos lwm lub lis piam kom txog thaum cov tshuaj tshem tawm hauv lub cev, thiab yog tias qhov mob tsis mus rau tus kws kho mob hlwb. Noj nws, koj yuav tsum tau them sai sai rau dab tsi yog sau nyob rau hauv cov lus qhia, thiab nws tseem tsis tau paub tias qhov mob siab yog dab tsi. Nco ntsoov, nws zoo nkaus li tias cov tshuaj tsis tau tshuaj xyuas kom meej.
Ib tug phooj ywg hauv tebchaws Canada tau tuag rau mob qog nqaij hlav. Thawj qhov kev kws kho mob ua tom qab ua kev paub tseeb yog sau tag nrho cov tshuaj uas nws noj. Ntawm lawv yog tus ntoo khaub lig. Nws txwv kiag tam sim ntawd. Nws muab tawm tias hauv Canada lawv sim tsis rau xaiv nws. Muaj cov kev cia siab loj heev tias cov tshuaj no ua rau mob cancer.
Txiv tuag haus Krestor tau peb xyoos. Cov tshuaj sai thiab ua rau cov roj (cholesterol) txo qis. Lawv xav kom tsis txhob noj cov tshuaj, tab sis tom qab tsis ua tiav, cov roj cholesterol rov qab ntxiv. Yog li, Kuv yuav tsum rov pib noj cov tshuaj. Tom qab ntawv, leej txiv tau pib yws yws txog mob taub hau, noj qab haus huv, pw tsis tsaug zog. Peb pom tawm vim li cas lub sijhawm ntev, dhau ntau yam kev sim. Thaum kawg, nws tau muab tawm tias nws txiv muaj teeb meem daim siab. Kev siv cov tshuaj tau dhau los ua tsis tau.
Txaus siab heev nrog cov tshuaj, txo sai thiab yuav luag tsis muaj kev phiv. Tsuas yog thaum so kuv haus Essentiale Forte N.
Tus kws kho mob tau tawm hauv 2 lub hlis txhawm rau txhawm rau tiv thaiv kev txhim kho cov quav hniav. Yuav (zoo li daim tseem). Kuv tsis tau muaj dua cov pob no rau hauv kuv lub neej! Qee hom pob txha liab vog thoob plaws lub cev. Kuv haus hnub 4, vim kuv xav tias nws muaj peev xwm ua tau rau Magnerot ua ke txais. Kuv pom tawm tias ntawm Krestor tom qab txhua yam. Yuav nyob li cas? NW nyuam qhuav tau tshem ntawm lub txim.
Myocardial infarction ua rau kuv xav thiab xav qhov kuv tau ua nrog kuv txoj kev noj qab haus huv! Txawm mus rau simulator. Kuv cov roj hauv siab tau nce siab, vim li ntawd lawv tau noj zaub mov nruj, rau rhaub thiab faus xwb, Kuv zoo siab Kuv tuaj yeem noj cov txiv hmab txiv ntoo, txwv tsis pub haus luam yeeb, nws nyuaj tag nrho. Kuv sim Krestor - Kuv lees txais nws raws li cov lus qhia, tab sis kuv tsis tau pom muaj kev tsis haum tshuaj. Nws tau los ua pa yooj yim, ntxiv rau kuv khiav ntawm lub cos, qoj ib ce nrog tus kws qhia. Cov tshuaj pab kom tau, tab sis kev ua kom tawm dag zog kuj zoo. Kuv tsis paub, tab sis kuv zoo dua kev siv tshuaj, tsis tseg, kom tsis txhob siv rau nws, Kuv ncua kev kho mob.
Tus ntoo khaub lig tau sau tseg rau kuv tus txiv tom qab lub plawv nres. Kev tsom xam pom tias nws muaj cov roj cholesterol ntau nyob hauv cov ntshav thiab yog li nws yuav tsum tau txo qis cov ntsuas no. Nrog rau kev siv cov tshuaj no tsis tu ncua thiab nrog kev noj haus nruj tshaj plaws, cov roj (cholesterol) yuav tsum pib poob zuj zus. Tsuas yog tom qab ib hlis twg qhov kev ntsuas tau pom tias cov ntshav cov ntshav nce siab mus txog qib uas tsim nyog. Tus kws kho mob pom zoo kom noj tom qab ntawd, tab sis nws yog cov tshuaj uas kim dua thiab tsis yog txhua tus neeg tuaj yeem noj nws nyob rau lub sijhawm ntev.
Cov lus qhia luv luv
Krestor (cov tshuaj nquag yog rosuvastatin) yog thawj cov tshuaj lipid-txo cov tshuaj uas yog pawg ntawm cov tshuaj tiv thaiv kev tiv thaiv ntawm cov enzyme HMG-CoA reductase, zoo dua lub npe hu ua statins. Lub yeeb koob ntawm "txoj haujlwm" ntawm txoj hlab ntshav liab tau ntev dua li peb lub teb chaws. Thaum kawg ntshav siab dhau los ua ib qho tseem ceeb ntawm txoj kev tsis taus thiab kev tuag los ntawm kab mob plawv. Nws tsis pub leejtwg paub tias kev txhim kho ntawm cov roj ntsha txhaws mus rau hauv tes nrog ntau yam teeb meem metabolic, xws li cov piam thaj tsis txaus, hyperinsulinemia (kev tso ntshav ntawm insulin ntau dhau), hypeuricemia (tshaj uric acid hauv cov ntshav), kev rog rog thiab dyslipidemia (cuam tshuam lipid metabolism). Nyob rau hauv rooj plaub tom kawg, kev kub siab yog txuam nrog kev nce ntxiv hauv cov ntsiab lus ntawm atherogenic lipid feem thiab vim li ntawd, txoj kev txhim kho atherosclerosis. Raws li kev tshawb fawb pom, hypercholesterolemia tshwm sim nyob rau hauv ntau dua 40% kev kuaj mob ntawm cov ntshav siab. Qhov ntxim siab, hauv cov txiv neej mob ntshav siab, lipid spectrum yog atherogenic ntau dua piv rau cov poj niam. Kev saib xyuas tsis txaus txaus them rau kev kho cov ntshav siab, nrog rau kev tshem tawm ntawm cov kab mob plawv, suav nrog dyslipidemia, ua rau kev txhim kho thiab txuas ntxiv ntawm atherosclerosis. Hauv qhov no, qhov ib txwm ua ntawm lipid metabolism yog ib lub hom phiaj tseem ceeb ntawm kev tswj cov neeg mob ntshav siab, txhais tau tias kev ua tiav, uas nrog rau kev ua neej kho kom zoo, yog kev siv statins. Cov txiaj ntsig ntawm kev sim tshuaj loj tshawb pom meej meej tias statins txo qhov kev pheej hmoo ntawm cov hlab plawv tshwm sim. Qhov chaw tshwj xeeb ntawm cov neeg sawv cev ntawm pab pawg no pharmacological tau los ntawm rosuvastatin (tus ntoo khaub lig), vim tias pom muaj txiaj ntsig zoo thoob ntiaj teb nrog rau "cov npoj yaig hauv khw". Krestor yog cov tshuaj siv hluavtaws uas siv rau hauv kev kho plawv txij thaum 2003. Nws txoj haujlwm raug tshawb fawb tau ua tib zoo kawm hauv ntau txoj kev sim, ua ke hauv cov npe dav dav GALAXY thiab npog ntau dua 45 txhiab tus neeg koom.
Tsis pub dhau lub moj khaum ntawm cov program no, cov txiaj ntsig zoo ntawm cov tshuaj ntawm lipid profile, cov cim ntawm kev ua mob nquag, qhov xwm ntawm chav kawm ntawm atherosclerotic txheej txheem tau lees paub. Thaum siv tus ntoo khaub lig hauv qhov ntau ntawm cov koob tshuaj pom zoo, qhov kev txo qis hauv qib "tsis zoo" cov roj (LDL) los ntawm 52–63% tau pom, uas ntau tshaj qhov zoo sib xws rau lwm cov statins. Ib qho ntxiv, thaum kho nrog tus ntoo khaub lig, theem ntawm cov roj "zoo" (HDL) tau lees tias nce - los ntawm thaj tsam 14%, nrog tib lub sij hawm txo qis hauv triglycerides. Muab hais tias kev txiav txim siab lub luag haujlwm ntawm kev hloov tshuaj tiv thaiv kab mob hauv lub pathogenesis ntawm atherosclerosis tsis yog tam sim no tsis ntseeg, kev saib xyuas tshwj xeeb yog muab rau cov laj thawj pom tseeb rau qhov cuam tshuam los tiv thaiv tus ntoo khaub lig. Ib txoj kev tshawb nrhiav tau ua nyob rau hauv uas cov tshuaj kom meej meej pom nws cov hauj lwm zoo rau kev mob plawv atherosclerosis: ob-xyoo hla kev kho mob tau txais txiaj ntsig tsis yog hauv kev txhim kho lipid profile thiab normalizing cim ntawm o, tab sis kuj nyob rau hauv regressing atherosclerosis nyob rau ntawm cov hlab ntshav liab thiab carotid cov hlab ntsha. Yog li, tus ntoo khaub lig yog rightfully suav tias qhov kev cog lus zoo tshaj plaws tsis tsuas yog cuam tshuam nrog kev txhim kho ntawm lipid profile, tab sis kuj nyob rau hauv kev tiv thaiv kev txhim kho ntawm atherosclerosis. Kev siv tus ntoo khaub lig ua tau zoo rau hauv kev tiv thaiv kab mob plawv ob leeg thiab theem siab. Cov txiaj ntsig kev kho mob ntawm cov tshuaj tshwm sim tsis pub dhau 7 hnub, thiab tom qab ib hlis ntawm lub lim tiam ntawm cov tshuaj kho mob nws nce mus txog qhov siab.
Tus ntoo khaub lig yog tsim tawm hauv cov ntsiav tshuaj, uas yuav tsum tau nqos tag nrho, tsis tsoo, ntxuav nrog qhov dej txaus. Cov tshuaj tuaj yeem siv tau txhua lub sijhawm ntawm ib hnub. Ua ntej thiab thaum kho, tus neeg mob yuav tsum tau ua raws li kev noj haus hypocholesterolemic ib txwm noj. Cov koob tshuaj ntawm tus ntoo khaub lig tau xaiv ib tus zuj zus nyob ntawm lub hom phiaj ntawm txoj kev kho mob, qhov pom tshwm sim thiab kev ua siab ntev rau tus neeg mob.
Crestor: cov lus qhia rau kev siv
| Pharmacological kev txiav txim | Krestor txo cov roj "LDL" cov roj (cholesterol) phem nyob rau hauv cov ntshav, ib feem los thaiv nws cov khoom hauv lub siab. Nws kuj txo cov tshuaj triglycerides, apolipoprotein B, lipoproteins tsawg kawg (VLDL). Tsa roj "HDL" zoo. Txo kev txo tus kab mob mus ntev hauv cov hlab. Txhim kho cov C-reactive protein thiab lwm cov cim ntawm kev mob. Cov txiaj ntsig ntawm kev kuaj ntshav pib txhim kho tom qab 1-2 lub lis piam, cov nyhuv siab tshaj plaws - tom qab 2-4 lub lis piam. |
| Cov Tshuaj Pharmacokinetics | Rosuvastatin ntsiav tshuaj tuaj yeem noj nrog zaub mov los yog ntawm lub plab khoob, qhov ua tau zoo ntawm qhov no tsis hloov. Rosuvastatin raug tawm hauv lub cev los ntawm 90% los ntawm lub siab los ntawm cov hnyuv, los ntawm 10% - los ntawm ob lub raum. Nws yog tsawg dua li lwm cov statins, nws thauj cov siab ua haujlwm hauv kev koom tes hauv kev ntxuav tu cov ntshav ntawm cov tshuaj nquag ntawm cov tshuaj. Vim qhov no, nws muaj tsawg dua kev sib txuam nrog lwm cov tshuaj dua li cov koob tshuaj yav dhau los. |
| Kev ntsuas rau siv | Txhawb cov roj (cholesterol) hauv cov neeg laus thiab cov hluas. Kev tiv thaiv ntawm kev txhim kho ntawm atherosclerosis. Kev tiv thaiv ntawm thawj zaug thiab rov ua plawv nres, ischemic stroke thiab lwm cov teeb meem ntawm atherosclerosis. Tom qab kev phais mob txhawm rau kom ntshav ntws hauv cov hlab ntsha cuam tshuam los ntawm atherosclerosis. C-reactive protein ntau nyob rau hauv cov ntshav nyob ib puag ncig ntawm lwm yam kev phom sij ntawm lub plawv, txawm tias cov roj (cholesterol) yog ib txwm muaj. Noj Krestor ntsiav tshuaj tsis yog hloov chaw rau kev ua neej zoo. Kawm cov lus "Kev tiv thaiv kev mob plawv thiab mob stroke" thiab ua li nws hais. Txwv tsis pub, cov tshuaj yuav pab me ntsis. |
Saib ntawm daim vis dis aus ntawd thiab:
| Tsuas tshuaj | Pib muab tshuaj ntau npaum 5 lossis 10 mg rau ib hnub. Tom qab 4 lub lis piam, cov koob tshuaj Krestor tuaj yeem raug nce ntxiv, vim tias cov qib roj cholesterol tau pauv pauv lub sijhawm no thiab kev mob siab rau tus neeg mob li cas. Kawm paub ntshav muaj roj rau cov txiv neej thiab poj niam raws hnub nyoog. Feem ntau, cov neeg mob noj rosuvastatin 10-20 mg ib hnub. Qhov siab tshaj plaws ntawm 40 mg yog kho feem ntau rau cov neeg uas lawv cov roj (cholesterol) yog qhov siab heev vim kev mob caj ces. Cov neeg laus, nrog rau cov neeg mob uas muaj mob raum me lossis mob siab tsis txaus, tau txhaj tshuaj rosuvastatin hauv cov koob tshuaj. |
| Sab sij huam | Krestor ntsiav tshuaj, zoo li lwm cov statins, tuaj yeem ua rau mob nqaij leeg, tsis muaj zog, nkees, nco qab thiab ua tib zoo xav, ua pob liab vog thiab plab zom mov.Tshawb xyuas cov ntawv sau "Sab phiv los ntawm statins" - nrhiav seb yuav txo cov tsos mob tsis zoo lossis tshem tawm tag nrho lawv. Rosuvastatin npaj tau lawv tus kheej tshwj xeeb phiv. Nyeem ntxiv uas rosuvastatin muaj kev nyab xeeb npaum li cas. Rau cov neeg uas muaj kev pheej hmoo siab ntawm lub plawv nres thiab mob hlab ntsha tawg, statins ua tau zoo dua li tsis raug. Cov tshuaj no yuav tsum tau tsum tsis ua ntxiv yog tias muaj kev phiv tshuaj rau tsis taus thiab nws tsis tuaj yeem txo lawv. Kev phom sij ntawm teeb meem mob siab yog exaggerated. Tsis txhob txhawj xeeb txog lawv yog tias koj tsis haus cawv. |
| Cov Yuav Tsum Muaj | Kab mob siab nyob rau theem nquag. Ib qho nce ntxiv ntawm daim siab enzymes ALT thiab AST hauv cov ntshav. Mob raum tsis ua haujlwm - kev tshem tawm creatinine tsawg dua 30 ml / min. Cov tshuaj tiv thaiv tsis haum rau rosuvastatin lossis cov neeg excipients uas ua cov ntsiav tshuaj. Hauv cov tebchaws hais lus Lavxias, cov hnub nyoog qis dua 18 yog suav tias yog kev sib kis, txawm hais tias txawv teb chaws, kev npaj rau rosuvastatin yog tsim rau cov hluas pib thaum muaj hnub nyoog 10 xyoo. |
| Cev xeeb tub thiab pub niam mis | Krestor, lwm yam tshuaj ntawm rosuvastatin thiab tag nrho lwm yam statins yog nruj me ntsis contraindicated thaum cev xeeb tub. Cov poj niam ntawm lub hnub nyoog yug menyuam uas tau kho nrog statins yuav tsum siv txoj kev tswj kom tsis pub muaj menyuam. Yog tias lub sijhawm tsis tau xeeb tub dua, tom qab ntawd kev noj tshuaj rau cov cholesterol yuav tsum nres tam sim ntawd. Tawm tsam keeb kwm ntawm kev kho mob nrog cov tshuaj no, koj tsis tuaj yeem pub niam mis. |
| Yeeb tshuaj sib cuam tshuam | Krestor ntsiav tshuaj muab tsawg dua qhov tsis sib txuam nrog lwm cov tshuaj dua li cov koob tshuaj yav dhau los. Tab sis tseem qhov txaus ntshai tseem nyob. Tej zaum yuav muaj teeb meem nrog tshuaj tua kab mob, tshuaj hloov kho lub cev tsis muaj zog, tshuaj noj kom txhob muaj menyuam, tshuaj noj ntshav, thiab lwm yam tshuaj. Qhov no tuaj yeem ua rau muaj kev mob tshwm sim heev - ua rau lub siab thiab lub raum tsis ua haujlwm. Tham nrog koj tus kws kho mob! Ua ntej koj yuav cov tshuaj statins, qhia rau koj tus kws kho mob txog txhua yam tshuaj, kev noj haus, thiab tshuaj ntsuab koj noj. |
| Noj ntau dhau | Nws tsis muaj ib txog kev kho tshwj xeeb rau kev noj ntau tshaj nrog Krestor. Cov kws kho mob muab cov kev mob tshwm sim thiab txhawb kev ntsuas, tshuaj xyuas lub siab kom ua haujlwm thiab qhov degree ntawm creatinine phosphokinase kev ua ub no. Hemodialysis pab tsis tau kom tshem rosuvastatin tawm hauv lub cev. |
| Cov lus qhia tshwj xeeb | Pib kho nrog statins, txuas ntxiv ua raws cov zaub mov noj thiab coj lub neej noj qab haus huv. Nws raug nquahu kom saib xyuas lub raum tsis tas siv ntshav thiab kuaj zis. Yog tias muaj protein ntau hauv cov zis lossis nws cov concentration nce ntxiv, them rau tus kws kho mob. Yog tias koj tsis muaj cov thyroid hormones txaus, tom qab ntawd tsis txhob maj noj cov tshuaj statins, tab sis kho hypothyroidism kom cov roj (cholesterol) rov qab ua dua. Krestor thiab lwm yam tshuaj ntawm rosuvastatin ntxiv rau cov ntshav qab zib hauv cov neeg mob ntshav qab zib thiab ntshav qab zib. |
| Daim ntawv tso tawm | Zaj duab xis-cov ntsiav tshuaj ntawm 10, 20 thiab 40 mg. Hauv cov hlwv los ntawm aluminium laminate lossis ntawv ci, 7 lossis 14 ntsiav tshuaj. Hauv ib pob ntawv ntawm cardboard, 1, 2 lossis 4 blisters. |
| Cov lus thiab cov xwm txheej ntawm kev cia | Txhawm rau khaws cia hauv qhov chaw qhuav, tiv thaiv los ntawm teeb, qhov chaw, tsis muaj rau cov menyuam yaus, ntawm qhov kub tsis siab tshaj 30 ° C. Txee lub neej yog 3 xyoos. |
| Muaj pes tsawg leeg | Cov tshuaj phiv yog rosuvastatin calcium. Cov neeg raug zam - lactose monohydrate, MCC, calcium phosphate, crospovidone, magnesium stearate. Lub plhaub ntawm cov ntsiav tshuaj yog lactose monohydrate, hypromellose, triacetin (glycerol triacetate), titanium dioxide, liab hlau zas oxide. |
Ntau tus neeg mob xav hloov cov tshuaj Krestor nrog qee cov tshuaj analogue, pheej yig dua, muaj cov tshuaj qub. Daim video hauv qab no yuav pab koj. Saib nws los ua qhov kev xaiv kom zoo ntawm ntau cov rosuvastatin ntsiav tshuaj muaj nyob ntawm cov chaw muag tshuaj.
Crestor: tshuaj xyuas
Hauv Lavxias-lus chaw koj tuaj yeem nrhiav tau kaum ob txheeb xyuas txog cov tshuaj Krestor. Cov tshuaj no tau nrov, txawm tias lawv cov nqi ntau. Thaum tib neeg sau kev tshuaj xyuas ntawm lwm cov tshuaj ntawm rosuvastatin (Mertenil, Roxer, Rosucard), lawv feem ntau yws txog lawv cov kev mob tshwm sim. Kev txheeb xyuas txog cov tshuaj Krestor yog tag nrho ntawm cov lus tsis txaus siab txog nws cov nqi siab. Tab sis ob peb sau phau ntawv hais txog phiv. Cov lus tshaj tawm txog cov chaw kho mob feem ntau txaus siab tias tus thawj rosuvastatin tshuaj txo lawv cov roj (cholesterol). Lawv chim siab tsuas yog tias tau muaj nyiaj ntau uas yuav tsum tau them nws.
Cov neeg mob paub tseeb tias txij li lawv tau noj rosuvastatin kim tshaj plaws, nws yuav tsis muaj kev mob tshwm sim lossis lawv yuav tsawg heev. Hloov chaw xaiv cov tshuaj Krestor, xaiv nws cov tshuaj pheej yig dua - Mertenil, Roxer, Rosucard lossis lwm tus - cov neeg txuag nyiaj. Txawm li cas los xij, lawv muaj kev ntseeg siab tias vim tias cov nyiaj khaws tseg lawv yuav tau ntsib ntau cov kev mob tshwm sim. Txawm hais tias cov kev tshawb fawb tshuaj placebo tau ua pov thawj tias qhov no tsis yog. Feem ntau cov kev mob tshwm sim ntawm statins uas tib neeg yws txog hauv lawv qhov kev txheeb xyuas yog tshwm sim los ntawm kev xav ntawm cov neeg mob tsis txaus siab, es tsis yog qhov cuam tshuam tiag tiag ntawm cov tshuaj.
Kev ntsuas rau siv
Fredrickson thawj hypercholesterolemia (hom IIa, suav nrog kev mob heterozygous hypercholesterolemia) lossis sib xyaw hypercholesterolemia (hom IIb) los ua ntxiv rau kev noj haus, thaum kev noj zaub mov noj thiab lwm yam tshuaj tsis siv tshuaj (xws li kev tawm dag zog, poob phaus) tsis txaus,
tsev neeg homozygous hypercholesterolemia raws li kev pab rau kev noj zaub mov noj thiab lwm txoj kev kho lipid-piv txwv (piv txwv li LDL-apheresis) lossis hauv rooj plaub uas qhov kev kho mob no pab tsis tau txaus,
hypertriglyceridemia (hom IV raws li Fredrickson) ua cov tshuaj ntxiv rau kev noj zaub mov,
maj mam hloov zuj zus ntawm atherosclerosis, ntxiv rau kev noj zaub mov noj rau cov neeg mob uas pom tias muaj kev kho mob kom txo qis cov roj cholesterol thiab LDL-C,
kev tiv thaiv thawj ntawm cov kev mob plawv tseem ceeb (mob stroke, plawv nres, hloov hlab plawv) hauv cov neeg laus tsis muaj kev soj ntsuam cov kab mob plawv, tab sis nrog kev pheej hmoo ntawm nws txoj kev loj hlob (ntau dua 50 xyoo rau cov txiv neej thiab laus dua 60 xyoo rau cov poj niam, nce siab ntawm C-reactive cov protein (≥2 mg / l) nyob rau ntawm qhov tsawg kawg ntawm ib qho kev pheej hmoo ntxiv, xws li mob ntshav siab, tsis tshua muaj siab HDL-C, haus luam yeeb, tsev neeg muaj keeb kwm thaum pib mob ntshav siab.
Sib tham txog cov tshuaj Crestor hauv cov ntaub ntawv ntawm niam
Rau kev sib piv, cov ntxhais kis tau ob peb cov tshuaj los txo qis cov roj ntshav Krestor 10 mg ntsiav tshuaj No. 28 - 1337 rubles, cov tshuaj nquag yog rosuvastatin, chaw tsim tshuaj paus - AstraZeneca-IPR Cov Tshuaj Tevastor 10 mg ntsiav tshuaj No. 30 - 471 rubles, cov tshuaj yeeb tshuaj yog rosuvastatin, chaw tsim tshuaj paus - TEVA / TEVA PHARMA Pom tam sim. qhov twg peb overpay rau lub hom. Cov ntaub ntawv los ntawm cov chaw muag tshuaj & n.
Cov. mi nyeem ntau ntawm cov ntawv nyeem ntawm cov ntawv tam sim no. Rosehip yog qhov zoo rau brew hauv ib lub thermos thaum hmo ntuj, muaj cov vitamins ntau, nws yog qhov tseem ceeb rau lub plawv thiab cov hlab ntsha. Cov. thiab thaum xub thawj lawv haus tshuaj, tam sim no peb haus tus ntoo khaub lig.
Peb muaj Plavix (ob zaug ib hnub), Krestor, Kleksan (hno), Kuv tsis nco qab tus so, nws tseem haus dej ntawm tes. Plavix hauv polycl. hauv Tatarstan nws hloov los ntawm Zilt - thiab nyob rau hauv Moscow nws raug txwv tsis pub haus dej haus hloov chaw, yog li nws haus txhua yam hauv qhov qub - peb muaj qee thaj chaw hauv thaj tsam ntawm 20,000 rubles. ploj mus ib hlis rau kev noj tshuaj.
Siv ob peb tshuaj Krestor thiab Tevastor, txhais tau tias kom txo qis cov ntshav roj hauv cov neeg mob atherosclerosis. Tevastor yog hom muaj sia ntawm Krestor thiab ob qho tib si yog ua raws Rosuvastatin, Tevastor yog peb zaug pheej yig dua thiab tsis qis dua qhov tsis zoo rau Krestor, tab sis nws muaj hom. Nov rau nws thiab.
Cov roj (cholesterol) nce siab me ntsis (yog li ntawd, Krestor tseem haus dej), txo qis siab feem ntau ntau dua 100/60 lossis 110/70, zoo li kuv li. Thawj theem ntawm atherosclerosis hauv nws. Omega yuam kom haus ib hlis dhau los, haus. Cov tshuaj calcium d3 tseem tseem haus dej haus cawv. Kuv tabtom xav, yog Krestor nrog Aspirin ok?
Oh, cov ntxhais, zoo nkauj npaum li cas uas kuv pom cov kev sib piv no. Kuv mam li bookmark nws. Tsaug rau qhov tseem ceeb info. Kuv txiv lees txais tus ntoo khaub lig thiab qee qhov nws kim me ntsis rau peb. Jessica, thiab koj tsis paub Tevastor tuaj yeem siv tam sim no tsis muaj kws kho mob sau ntawv, tsuas tus nqi sib txawv pom heev. Thiab dab tsi muaj txiaj ntsig tom qab thov Tevastor yog tib yam li p.
Cov. Oy - qhov no twb zoo heev lawm. Nws zoo nkaus li tsis muaj dab tsi tsis zoo nrog kev sib xyaw ntawm ob cov tshuaj no. Tsawg kawg yog kuv ib zaug tau txiav txim atherosclerosis nrog vasilip thiab cov tshuaj aspirin ua ke. Thiab raws li kuv nkag siab nws, tus ntoo khaub lig thiab vasilip los ntawm ib qhov ua yeeb yam. Muaj tseeb, Kuv tsis tau haus - vasilip tsis yog ib yam tshuaj uas koj tuaj yeem cev xeeb tub :-)
Qhov ua tau zoo ntawm Tevastor yog tib yam li qhov ntawm Crestor. tom qab tag nrho, ob qho tshuaj muaj tshuaj rosuvastatin, tab sis Anya yuav tsum tau noj tsuas yog qhia los ntawm kws kho mob!
Nws haus ib qho ntoo khaub lig (tevastor). kev tiv thaiv thawj ntawm cov kev mob plawv tseem ceeb (mob stroke, plawv nres, hloov hlab plawv) hauv cov neeg laus tsis muaj kev soj ntsuam cov kab mob plawv, tab sis nrog kev pheej hmoo ntawm nws txoj kev loj hlob (ntau dua 50 xyoo rau cov txiv neej thiab laus dua 60 xyoo rau cov poj niam, nce siab ntawm C-reactive cov protein ntau (≥2 mg / l) nyob rau ntawm qhov tsawg kawg ntawm ib qho kev pheej hmoo ntxiv, xws li mob ntshav siab, ntshav qis ntawm HDL-C, haus luam yeeb, kev tshaib plab.
Kuv tsis tau muaj mob. Kuv nyeem hauv net, txhua qhov zoo ib yam, nws fibrinogen siab, txawm tias muaj hnub nyoog ntsig txog. thiab peb txhua tus muaj teeb meem mob ntshav hauv tsev neeg. txhua tus neeg tuag los ntawm tus no, lossis los ntawm mob cancer. dumbly: (Kuv xav tias peb tuaj yeem ntxiv tshuaj Aspirin-cardio rau Krestor? Nws yuav tsis mob. Tsis muaj ib qho mob chuv ntshav hauv lub siab krestor. Nws muaj ntshav siab thiab pib atherosclerosis + nws haus luam yeeb
Kws Tshuaj
Tus neeg sawv cev hypolipidemic los ntawm pab pawg ntawm statins, ib qho tshuaj tiv thaiv HMG-CoA reductase. Raws li lub hauv paus ntsiab lus ntawm kev sib tw kev sib tua, ib qho statin qauv qauv khi rau qhov ntawd ntawm coenzyme A receptor qhov twg no enzyme txuas. Lwm feem ntawm statin lwg me me tiv thaiv kev hloov pauv ntawm hydroxymethylglutarate rau mevalonate, ib qho nruab nrab hauv cov hluavtaws sib xyaw ua ke ntawm cov roj (molecules) roj. Kev txwv tsis pub muaj kev ua haujlwm ntawm HMG-CoA reductase ua rau muaj cov kev hloov tshwm sim ntxiv, ua rau muaj qhov txo qis ntawm cov roj uas txhaws txaus thiab muaj kev cuam tshuam hauv kev ua haujlwm ntawm LDL receptors thiab, raws li, kev nrawm catabolism ntawm LDL cov roj (Xc).
Cov nyhuv hypolipidemic ntawm statins yog txuam nrog qhov kev txo qis ntawm tag nrho cov cholesterol vim LDL cov cholesterol. Qhov txo qis hauv LDL yog koob tshuaj-siv thiab tsis yog linear, tab sis exponential.
Statins tsis cuam tshuam rau kev ua haujlwm ntawm lipoprotein thiab hepatic lipases, tsis txhob cuam tshuam ntau qhov kev sib txuas thiab catabolism ntawm cov roj ntsha dawb, yog li ntawd, lawv cov txiaj ntsig ntawm theem TG yog theem nrab thiab tsis ncaj los ntawm lawv cov kev cuam tshuam tseem ceeb los txo qis LDL-C. Kev poob qis hauv theem ntawm TG thaum kho nrog statins pom meej cuam tshuam nrog kev qhia ntawm cov seem (apo E) receptors nyob rau saum npoo ntawm hepatocytes koom nrog catabolism ntawm STD, uas muaj li 30% TG.
Ntxiv rau qhov teebmeem lipid-txo qis, statins muaj cov txiaj ntsig zoo ntawm endothelial kawg (preclinical kos npe ntawm thaum ntxov atherosclerosis), nyob rau ntawm phab ntsa vascular, atheroma lub xeev, txhim kho rheological ntshav, muaj antioxidant, antiproliferative zog.
Cov kev kho mob nyhuv yog manifested nyob rau hauv 1 lub lim tiam. tom qab pib txoj kev kho thiab tom qab 2 lub lis piam ntawm kev kho yog 90% ntawm lub siab tshaj plaws ua tau cov txiaj ntsig, uas feem ntau ua tiav los ntawm 4 lub lis piam thiab tom qab ntawd tas mus li.
Cov Tshuaj Pharmacokinetics
Tom qab cov ncauj lus Cmax plasma rosuvastatin tau nce mus txog 5 teev. Bioavailability li 20%.
Rosuvastatin accumulates hauv lub siab. Vd - txog 134 litres. Kev khi rau cov ntshav plasma protein (feem ntau nrog albumin) yog kwv yees li 90%.
Biotransforms rau ib qho me me (li 10%), yog qhov tsis yog tub ntxhais hauv av rau isoenzymes ntawm cytochrome P system450Cov. Lub ntsiab isoenzyme koom nrog hauv cov metabolism hauv rosuvastatin yog CYP2C9. Isoenzymes CYP2C19, CYP3A4 thiab CYP2D6 tsawg koom nrog cov metabolism.
Lub ntsiab metabolites ntawm rosuvastatin yog N-dismethyl thiab lactone metabolites. N-dismethyl yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin, lactone metabolites yog cov tshuaj pharmacologically tsis ua haujlwm.
Txog li 90% ntawm koob tshuaj rosuvastatin yog pom tsis hloov pauv nrog quav. Cov seem yog tawm hauv zis. Ntshav T1/2 - txog 19 teev T1/2 tsis hloov nrog nce dua koob tshuaj. Qhov ntsuas ntshav ntshav nruab nrab yog kwv yees li 50 l / h (coefficient ntawm kev hloov pauv 21.7%).
Xws li lwm cov tshuaj tiv thaiv HMG-CoA-reductase, daim nyias nyias daim nyias nyias Xc koom nrog kev kho mob ntawm hepatic ntawm rosuvastatin, uas ua lub luag haujlwm tseem ceeb hauv kev kho mob hepatic ntawm rosuvastatin.
Kev raug rau lub cev zuj zus ntawm rosuvastatin nce ntxiv hauv kev faib ua feem.
Hauv cov neeg mob uas mob raum tsis zoo (QC txhua
Analogs Crestor
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 54 rubles. Cov analogue yog pheej yig dua los ntawm 606 rubles
Qhov sib tw raws cov cim
Nqe los ntawm 324 rubles. Cov analogue yog pheej yig dua los ntawm 336 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 345 rubles. Cov analogue yog pheej yig dua los ntawm 315 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 369 rubles. Cov analogue yog pheej yig dua los ntawm 291 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 418 rubles. Cov pev txig yog cov pheej yig dua los ntawm 242 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 438 rubles. Cov analogue yog pheej yig dua los ntawm 222 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 604 rubles. Cov analogue yog pheej yig dua los ntawm 56 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 737 rubles. Cov analogue yog cov nqi ntau dua ntawm 77 rubles
Qhov sib tw raws cov cim
Tus nqi yog los ntawm 865 rubles. Cov kab xev analogue kim dua los ntawm 205 rubles
Daim ntawv noj tshuaj:
Txhua cov ntsiav tshuaj muaj cov tshuaj nquag: rosuvastatin 10, 20 lossis 40 mg nyob rau hauv daim ntawv ntawm calcium rosuvastatin.
Cov muaj tswv yim: lactose monohydrate 89.50 mg (rau qhov tau ntau npaum ntawm 10 mg), 179.00 (rau qhov ntau npaum li 20 mg), 164.72 mg (rau kev noj tshuaj ntawm 40 mg), microcrystalline cellulose 29.82 mg (rau qhov ntau npaum li 10 mg), 59.64 mg (rau qhov ntau npaum ntawm 20 mg), 54.92 mg (rau qhov tshuaj ntau npaum li 40 mg), calcium phosphate 10.90 mg (rau tshuaj rau 10 mg), 21.80 mg (rau qhov tshuaj ntau npaum li 20 mg), 20.00 mg (rau qhov muab tshuaj. 40 mg), crospovidone 7.50 mg (rau qhov tau ntau npaum ntawm 10 mg), 15.00 mg (rau qhov tau ntau npaum ntawm 20 mg), 15.00 mg (rau kev noj ntau npaum li 40 mg), magnesium stearate 1.88 mg (rau kev noj tshuaj ntawm 10 mg) 3.76 mg (rau kev noj tshuaj ntawm 20 mg), 3.76 mg (rau tshuaj rau 40 mg), plhaub taum: lactose monohydrate 1.80 mg (rau kev noj tshuaj ntawm 10 mg), 3.60 mg (rau qhov tshuaj ntau npaum li 20 mg), 3.60 mg (rau tshuaj rau 40 mg), hypromellose 1.26 mg (rau qhov ntau npaum li 10 mg), 2.52 mg (rau qhov ntau npaum ntawm 20 mg), 2.52 mg (rau qhov ntau npaum ntawm 40 mg), triacetin (glycerol triacetate) 0.36 mg (rau qhov ntau npaum li 10 mg), 0.72 mg (rau qhov ntau npaum ntawm 20 mg), 0.72 mg (rau kev noj tshuaj ntawm 40 mg), titanium dioxide 1.06 mg (rau qhov tshuaj ntau npaum li 10 mg), 2.11 mg (rau qhov tshuaj ntau npaum li 20 mg), 2.11 mg (rau kev noj tshuaj ntawm 40 mg), hlau zas hlau oxide liab 0.02 mg (rau qhov tshuaj ntau npaum li 10 mg), 0.05 mg (rau tshuaj rau 20 mg), 0.05 mg (rau tshuaj rau 40 mg).
Kev piav qhia
Ntsiav tshuaj 10 mg: puag ncig, ntsiav tshuaj biconvex, pleev xim nrog cov xaum xim zaj duab xis, txho nrog "ZD4522 10" ntawm ib sab.
Cov ntsiav tshuaj 20 mg: puag ncig biconvex ntsiav tshuaj, coated nrog cov yeeb yaj kiab zaj duab xis membrane, sau nrog "ZD4522 20" ntawm ib sab.
40 mg ntsiav tshuaj: oval, biconvex ntsiav tshuaj, them nrog zaj duab xis paj yeeb daim nyias nyias, sau nrog "ZD4522" ntawm ib sab thiab 40 ntawm lwm yam.
Cov chaw muag tshuaj
Mechanism ntawm kev ua
Rosuvastatin yog kev xaiv, kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonate, cov khoom siv roj ua ntej. Lub hom phiaj tseem ceeb ntawm kev ua ntawm rosuvastatin yog lub siab, qhov twg cov synthesis ntawm cov roj (cov cholesterol) thiab catabolism ntawm lipoproteins tsawg ntom (LDL) yog nqa tawm.
Rosuvastatin nce tus naj npawb ntawm "daim siab" LDL receptors rau ntawm lub ntsej muag ntawm tes, nce kev nce siab thiab catabolism ntawm LDL, uas ua rau cov inhibition ntawm cov hluavtaws lipoproteins tsawg heev (VLDL), yog li txo tag nrho cov nyiaj ntawm LDL thiab VLDL.
Cov Tshuaj Hauv Tshuaj
Krestor ® txo cov kev nce siab ntau ntawm LDL cov roj (cov roj cholesterol-LDL), cov roj (cholesterol) tag nrho, triglycerides (TG), cov tshuaj roj lipoprotein ntau dua cov roj (HDL-C), thiab txo qis cov tshuaj apolipoprotein B (ApoV), cov roj uas tsis yog HDL, -LVONP, TG-VLDLP thiab nce siab ntawm apolipoprotein AI (ApoA-I) (saib cov lus 1 thiab 2), txo qhov feem ntawm LDL-C / HDL-HDL, tag nrho cov roj cholesterol / HDL-C thiab HDL-C / HDL-C thiab ApoB / ApoA-Kuv Piv.
Kev ua rau txoj kev kho kom zoo dua qub hauv ib lub lis piam tom qab pib kho nrog Krestor ®, tom qab 2 lub lis piam ntawm kev kho mob nce mus txog 90% ntawm cov txiaj ntsig siab tshaj plaws.
Kev kho mob siab tshaj plaws feem ntau ua tiav los ntawm 4 lub lim tiam ntawm txoj kev kho thiab tswj nrog kev siv cov tshuaj tsis tu ncua.
Rooj 1 Cov. Koob-nyob rau cov nyhuv hauv cov neeg mob uas muaj tus mob hypercholesterolemia (hom IIa thiab IIb raws li Fredrickson) (qhov ntsuas nruab nrab tau hloov kho feem ntau piv rau tus nqi pib).
| Koob tshuaj | Qty ntawm cov neeg mob | HS-LDL | General roj | HS-HDL | TG | HS-tsis-HDL | ApoV | ApoA-Kuv |
| Tso cov tshuaj | 13 | -7 | -5 | 3 | -3 | -7 | -3 | 0 |
| 10 mg | 17 | -52 | -36 | 14 | -10 | -48 | -42 | 4 |
| 20 mg | 17 | -55 | -40 | 8 | -23 | -51 | -46 | 5 |
| 40 mg | 18 | -63 | -46 | 10 | -28 | -60 | -54 | 0 |
Rooj ntawv 2 Cov. Koob tshuaj-cov nyhuv hauv cov neeg mob uas muaj hypertriglyceridemia (hom IIb thiab IV raws li Fredrickson) (qhov feem pua qhov hloov pauv piv rau qhov pib nqi).
| Koob tshuaj | Qty ntawm cov neeg mob | TG | HS-LDL | General roj | HS-HDL | HS-tsis-HDL | HS-VLDLP | TG-lponp |
| Tso cov tshuaj | 26 | 1 | 5 | 1 | -3 | 2 | 2 | 6 |
| 10 mg | 23 | -37 | -45 | -40 | 8 | -49 | -48 | -39 |
| 20 mg | 27 | -37 | -31 | -34 | 22 | -43 | -49 | -40 |
| 40 mg | 25 | -43 | -43 | -40 | 17 | -51 | -56 | -48 |
Cov chaw kho mob ua tau Krestor effective ua tau zoo rau cov neeg mob laus neeg mob hypercholesterolemia nrog lossis tsis muaj hypertriglyceridemia, tsis hais haiv neeg twg, poj niam lossis txiv neej, nrog rau cov neeg mob ntshav qab zib mellitus thiab tsev neeg hypercholesterolemia. Hauv 80% ntawm cov neeg mob uas muaj hom IIa thiab IIb hypercholesterolemia raws li Fredrickson (qhov pib nruab nrab ntawm LDL-C yog txog 4.8 mmol / L) thaum noj cov tshuaj ntawm 10 mg, qhov siab ntawm LDL-C nce mus txog tsawg dua 3 mmol / L.
Hauv cov neeg mob uas mob heterozygous tsev neeg hypercholesterolemia tau txais Krestor ® ib koob ntawm 20-80 mg, qhov zoo ntawm qhov lipid profile tau pom (kev kawm txog 435 tus neeg mob). Tom qab ua ntawv cog lus rau ib koob tshuaj 40 mg ib zaug ib zaug (12 lub lim tiam ntawm kev kho), qhov txo qis hauv cov ntsiab lus ntawm LDL-C los ntawm 53% tau sau tseg. Hauv 33% ntawm cov neeg mob, ib qho LDL-C concentration ntawm tsawg dua 3 mmol / L yog ua tiav.
Hauv cov neeg mob nrog homozygous tsev neeg hypercholesterolemia noj Krestor ® ntawm ib koob ntawm 20 mg thiab 40 mg, qhov nruab nrab txo hauv LDL-C concentration yog 22%.
Hauv cov neeg mob hypertriglyceridemia nrog kev pib ntawm TG los ntawm 273 txog 817 mg / dl uas tau txais Krestor ® hauv ib koob ntawm 5 mg txog 40 mg ib hnub ib zaug rau 6 lub lis piam, cov ntsiab lus ntawm TG hauv cov ntshav ntshav tau txo qis (saib cov lus 2 )
Muaj cov txiaj ntsig zoo ntxiv tau pom nrog kev fenofibrate piv rau cov concentration ntawm triglycerides thiab nrog nicotinic acid hauv lipid txo cov koob tshuaj uas muaj feem cuam tshuam nrog qhov kev nkag siab ntawm HDL-C (kuj saib ntu "Cov Lus Qhia Tshwj Xeeb").
Hauv txoj kev tshawb nrhiav METEOR hauv 984 cov neeg mob hnub nyoog 45-70 xyoo uas muaj qhov pheej hmoo tsawg ntawm kev txhim kho cov hlab plawv (CHD) (kev pheej hmoo 10 xyoo ntawm Framingham nplai tsawg dua 10%), qhov nruab nrab LDL cov roj cholesterol ntawm 4.0 mmol / L (154.5 mg / dl) thiab subclinical atherosclerosis (uas tau soj ntsuam los ntawm cov tuab ntawm cov carotid artery intima-media complex - TCIM) tau kawm txog cov nyhuv ntawm rosuvastatin ntawm lub thickness ntawm intima-media complex. Cov neeg mob tau txais rosuvastatin ntawm ib koob ntawm 40 mg / hnub lossis placebo rau 2 xyoos.
Rosuvastatin txoj kev kho mob maj mam ua qhov kev nce qib ntawm qhov siab tshaj plaws TCIM rau 12 ntu ntawm cov carotid artery piv nrog cov placebo nrog qhov sib txawv ntawm -0.0145 mm / xyoo 95% kev ntseeg siab ntawm -0.0196 txog -0.0093, p ® 40 mg tsis pom zoo. Ib koob tshuaj 40 mg yuav tsum tau siv rau hauv cov neeg mob uas muaj mob hypercholesterolemia ntau dua thiab muaj kev pheej hmoo siab ntawm cov kab mob plawv (CVD).
Cov txiaj ntsig ntawm JUPITER txoj kev kawm (Lub ntsiab lus tseem ceeb rau kev siv statins rau kev tiv thaiv thawj: kev tshawb nrhiav tshuaj ntsuas rosuvastatin) hauv 17802 cov neeg mob pom tias rosuvastatin txo qis kev pheej hmoo ntawm cov hlab plawv mob (252 hauv cov pawg placebo piv rau 142 hauv pab pawg rosuvastatin) (p Cov txiaj ntsig ntawm kev kho tau pom tias tom qab thawj 6 lub hlis ntawm kev siv cov tshuaj, muaj ib qho kev xav pom tsawg kawg ntawm 48% hauv cov txheej txheem ua ke, suav nrog kev tuag los ntawm kev mob plawv, insulin. m thiab myocardial infarction (teeb meem piv: 0,52, 95% cog qoob loo luv 0,40-0,68, p ® nyob rau hauv cov me nyuam nyob rau hauv 18 xyoo.
Cov neeg mob mob siab tsis ua haujlwm
Tsis muaj cov ntaub ntawv lossis kev paub txog kev siv tshuaj nyob hauv cov neeg mob uas tau tus qhab nia siab dua 9 ntawm Kev Siv Me Nyuam-Pugh (saib ntu "Pharmacodynamics" thiab "Cov Lus Qhia Tshwj Xeeb").
Tsuas tshuaj thiab tswj hwm
Sab hauv, tsis txhob zom los yog zom lub ntsiav tshuaj, nqos tag nrho, ntxuav nrog dej. Cov tshuaj tuaj yeem tuaj yeem sau lub sijhawm thaum nruab hnub, tsis hais noj zaub mov noj.
Ua ntej pib kev kho mob nrog Krestor ®, tus neeg mob yuav tsum pib ua raws li cov qauv hypocholesterolemic noj haus thiab txuas ntxiv ua raws nws thaum kho. Cov koob tshuaj ntawm cov tshuaj yuav tsum tau xaiv ib tus zuj zus nyob ntawm lub hom phiaj ntawm txoj kev kho thiab kho cov lus teb rau kev kho mob, suav txog cov lus pom zoo tam sim no ntawm lub hom phiaj ntawm lipids.
Qhov pom zoo kom pib noj rau cov neeg mob pib noj cov tshuaj, lossis rau cov neeg mob hloov mus los ntawm kev noj lwm yam HMG-CoA reductase inhibitors, yuav tsum yog 5 lossis 10 mg ntawm Krestor ® ib hnub ib zaug. Thaum xaiv kev noj tshuaj thawj zaug, ib qho yuav tsum tau ua los ntawm cov tib neeg cov mob cov cholesterol thiab coj mus rau hauv tus account qhov kev pheej hmoo ntawm cov mob plawv, thiab nws tseem yog qhov yuav tsum tau los soj ntsuam qhov muaj feem ntawm kev mob tshwm sim. Yog tias tsim nyog, cov koob tshuaj tuaj yeem nce ntxiv mus rau qhov ntau dua tom qab 4 lub lis piam (saib ntu "Pharmacodynamics").
Hauv kev sib txuas nrog kev txhim kho kev mob tshwm sim thaum siv ib koob tshuaj 40 mg, piv nrog koob tshuaj qis dua (saib Ntu "Kev Phiv Los Ntawm Sab"), nce qhov koob tshuaj rau 40 mg tom qab ib qho kev noj tshuaj ntxiv yog siab dua qhov pom zoo thawj zaug rau 4 lub lis piam kev kho tuaj yeem nqa tawm tsuas yog hauv cov neeg mob uas muaj mob siab hypercholesterolemia thiab muaj kev pheej hmoo siab heev ntawm cov hlab plawv (tshwj xeeb tshaj yog rau cov neeg mob nrog tsev neeg hypercholesterolemia) uas tsis tau tiav qhov xav tau tshwm sim ntawm txoj kev kho thaum noj ib koob tshuaj 20 mg, thiab leej twg yuav muaj nyob rau hauv tus kws saib xyuas (saib. "qhia tshwj xeeb" section).
Pom zoo tshwj xeeb kev saib xyuas ntawm cov neeg mob tau txais cov tshuaj hauv ib koob tshuaj 40 mg yog pom zoo.
Kev noj tshuaj ntawm 40 mg tsis pom zoo rau cov neeg mob uas tsis tau mus ntsib kws kho mob dhau los.
Tom qab 2-4 lub lis piam ntawm kev kho thiab / lossis nrog kev nce ntxiv ntawm qhov koob tshuaj Krestor ® kev npaj, kev soj ntsuam cov lipid metabolism yog tsim nyog (kev hloov kho koob tshuaj yog tsim nyog yog tias tsim nyog).
Cov neeg laus cov neeg mob
Koob tshuaj yuav tsis haum.
Cov neeg mob raum tsis ua haujlwm
Hauv cov neeg mob uas mob mentsis lossis mob raum tsis ua haujlwm, koob tshuaj yuav tsis tas kho. Hauv cov neeg mob uas mob raum tsis zoo (CC tsawg dua 30 ml / min.), Kev siv cov tshuaj Krestor ® yog contraindicated.
Kev siv cov tshuaj nyob rau hauv ib koob ntawm 40 mg yog contraindicated nyob rau hauv cov neeg mob uas tsis tshua muaj lub raum tsis ua haujlwm (CC tsawg dua 30-60 ml / min.) (Saib Ntu "Cov Lus Qhia Tshwj Xeeb" thiab "Pharmacodynamics"). Rau cov neeg mob uas ua tsis zoo raum lub raum kev ua haujlwm, kev pom zoo thawj zaug ntawm 5 mg yog kev pom zoo.
Cov neeg mob mob siab tsis ua haujlwm
Krestor ® yog contraindicated rau hauv cov neeg mob uas muaj kab mob siab hauv theem ua haujlwm (saib ntu "Kev Pom Tsis Zoo").
Tshwj xeeb cov neeg. Ib pawg haiv neeg
Thaum kawm cov tshuaj pharmacokinetic ntawm rosuvastatin hauv cov neeg mob koom nrog cov pab pawg neeg sib txawv, kev nce qib hauv cov kab ke ntawm rosuvastatin ntawm cov neeg Nyij Pooj thiab Suav tau sau tseg (saib Ntu "Cov Lus Qhia Tshwj Xeeb"). Qhov tseeb no yuav tsum raug coj los txiav txim thaum sau ntawv rau Krestor ® rau cov pab pawg neeg mob. Thaum sau tshuaj ntawm 10 thiab 20 mg, koob tshuaj pom zoo thawj zaug rau cov neeg mob ntawm haiv neeg Mongoloid yog 5 mg. Kev tswj hwm tshuaj nyob rau hauv ib koob ntawm 40 mg yog contraindicated rau cov neeg mob ntawm haiv neeg Mongoloid (saib ntu "Contraindications").
Caj ces polymorphism
Tus neeg nqa khoom ntawm genotypes SLC01B1 (OATP1B1) c.521CC thiab ABCG2 (BCRP) c.421AA pom tias muaj kev nce ntxiv (AUC) rau rosuvastatin piv rau cov nqa khoom ntawm genotypes SLC01B1 c.521TT thiab ABCG2 c.421CC. Rau cov neeg mob nqa tshuaj genotypes c.521CC lossis c.421AA, qhov pom zoo siab tshaj plaws ntawm Crestor ® yog 20 mg ib hnub ib zaug (saib ntu "Pharmacokinetics", "Cov Lus Qhia Tshwj Xeeb" thiab "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom Tshuaj Tiv Thaiv" )
Cov neeg mob Myopathy
Kev tswj hwm ntawm cov tshuaj ntawm ib koob ntawm 40 mg yog contraindicated rau hauv cov neeg mob uas muaj qee yam uas yuav qhia tau qhov kev xav ua ntej rau kev txhim kho ntawm myopathy (saib ntu "Contraindications"). Thaum muab tshuaj ntawm 10 thiab 20 mg, kev pom zoo muab thawj koob rau cov neeg mob no yog 5 mg (Saib Ntu "Kev Pom Tsis Zoo")
Ntsuas kev kho mob
Rosuvastatin khi rau ntau cov thauj cov protein (tshwj xeeb, OATP1B1 thiab BCRP). Thaum muab sib xyaw nrog Krestor ®, nrog cov tshuaj (xws li cyclosporine, qee cov kab mob HIV tiv thaiv kab mob tiv thaiv, suav nrog kev sib xyaw ntawm ritonavir nrog atazanavir, lopinavir thiab / lossis tipranavir), uas ua rau kev nce siab ntawm rosuvastatin hauv plasma vim muaj kev cuam tshuam nrog kev thauj cov protein, txoj kev pheej hmoo ntawm myopathy (suav nrog rhabdomyolysis) (saib ntu "Cov lus qhia tshwj xeeb" thiab "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom tshuaj"). Koj yuav tsum nyeem cov lus qhia rau kev siv cov tshuaj no ua ntej lawv teem ua ke nrog tshuaj Krestor ®. Hauv cov xwm txheej zoo li no, koj yuav tsum tau soj ntsuam qhov ua tau los ntawm kev muab tshuaj kho lwm txoj kev kho lossis txiav ib ntus kev siv cov tshuaj Krestor ®. Yog tias kev siv cov tshuaj saum toj no tsim nyog, koj yuav tsum ntsuas qhov piv ntawm cov txiaj ntsig thiab kev pheej hmoo ntawm kev kho mob concomitant nrog cov tshuaj Crestor and thiab xav txog qhov muaj peev xwm txo nws cov tshuaj (saib ntu "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm yam kev sib txuas lus tshuaj").
Sab sij huam
Cov kev mob tshwm sim thaum pom tias siv tshuaj Krestor usually feem ntau yog me me thiab ploj mus nws tus kheej. Ib yam li lwm yam HMG-COL reductase inhibitors, qhov tshwm sim ntawm cov kev mob tshwm sim yog feem ntau koob tshuaj.
Qhov ntau zaus ntawm kev cuam tshuam tsis zoo yog nthuav tawm raws li hauv qab no:
feem ntau (> 1/100, 1/1000, 1/10000, ®, cov kab mob proteinuria tuaj yeem kuaj pom. Kev hloov pauv ntawm cov protein ntau hauv cov zis (los ntawm qhaj ntawv los yog cov nyiaj taug rau ++ lossis ntau dua) tau pom hauv tsawg dua 1% ntawm cov neeg mob tau txais 10-20 mg cov tshuaj, thiab hauv kwv yees li 3% ntawm cov neeg mob tau txais 40 mg ntawm tshuaj.
Kev hloov me ntsis ntawm cov protein hauv cov zis tau pom thaum noj ib koob ntawm 20 mg. Feem ntau, cov proteinuria txo qis lossis ploj mus thaum kho mob thiab tsis txhais tau tias muaj tshwm sim ntawm cov mob raum sai los yog hloov kho uas twb muaj lawm.
Los ntawm cov leeg musculoskeletal
Thaum siv cov tshuaj Krestor ® hauv txhua qhov tshuaj, thiab tshwj xeeb tshaj yog thaum noj cov tshuaj ntau dua 20 mg, cov teebmeem hauv qab ntawm cov leeg mob tau qhia: myalgia, myopathy (suav nrog myositis), muaj qee yam mob tsawg, rhabdomyolysis nrog lossis tsis muaj mob raum tsis zoo. nws nws.
Kev txhaj tshuaj nce ntxiv hauv qhov kev ua si ntawm creatine phosphokinase (CPK) raug pom nyob hauv qee tus neeg mob tsawg tus noj rosuvastatin. Feem ntau, nws mob sib khuav, asymptomatic thiab ib ntus. Thaum muaj kev ua haujlwm ntau dua ntawm CPK (ntau dua 5 zaug piv nrog qhov txwv qis dua ntawm ib txwm), txoj kev kho yuav tsum raug tso tseg (saib Ntu "Cov Lus Qhia Tshwj Xeeb").
Los ntawm lub siab
Thaum siv rosuvastatin, qhov kev siv tshuaj ntau ntxiv rau cov haujlwm ntawm "nplooj siab" hloov pauv tau pom nyob ntawm qee tus neeg mob. Feem ntau, nws tsis tseem ceeb, asymptomatic thiab ib ntus.
Kev ntsuas ntsuas
Thaum siv cov tshuaj Krestor ®, cov kev hloov hauv qab no hauv chav kuaj kuj tau pom: ib qho kev nce ntawm cov kua nplaum, bilirubin, cov haujlwm ntawm gamma-glutamyl transpeptidase, alkaline phosphatase, thiab kev ua haujlwm ntawm lub qog ua haujlwm.
Tom qab muag kev thov
Cov kev mob tshwm sim hauv qab no tau tshaj tawm nyob rau tom qab siv tshaj tawm ntawm Krestor K:
Los ntawm cov kab mob hematopoietic
Qhov ntau zaus tsis paub tseeb: thrombocytopenia
Los ntawm cov hnyuv
Tsis tshua muaj: mob daj ntseg, kab mob siab
Tsis tshua muaj: kev ua si ntau ntawm "daim siab" hloov tsheb
Tsis tso cai ntau zaus: zawv plab
Los ntawm cov leeg musculoskeletal
Tsis tshua muaj heev: arthralgia
Tsis tshua muaj pes tsawg zaus: immuno-mediated necrotizing myopathy
Los ntawm lub hauv nruab nrab poob siab
Tsis tshua muaj heev: nco ploj lossis poob
Tsis paub meej pes tsawg zaus: peripheral neuropathy
Los ntawm lub tshuab ua pa
Cov zaus uas tsis tau tso cai: hnoos, txog siav
Los ntawm cov kab mob zis
Tsis tshua muaj heev: hematuria
Ntawm feem ntawm daim tawv nqaij thiab cov rog rog subcutaneous
Tsis siv ntau zaus: Stevens-Johnson syndrome
Los ntawm kev yug me nyuam thiab qog mammary caj pas
Cov zaus uas tsis tau hais txog: gynecomastia
Lwm yam
Qhov ntau thiab tsawg zaus uas tsis tau lees paub: peripheral edema
Thaum siv qee yam statins, cov kev mob tshwm sim hauv qab no tau tshaj tawm:
kev nyuaj siab, pw tsaug zog ntxhov siab, suav nrog insomnia thiab "npau suav phem" npau suav, kev sib deev tsis txaus ntseeg, hyperglycemia, nce siab ntawm glycosylated hemoglobin.
Cais tawm tus neeg mob ntsws mob ntsws interstitial tau qhia tawm, tshwj xeeb nrog kev siv tshuaj ntev (saib Ntu "Cov lus qhia tshwj xeeb").
Noj ntau dhau
Nrog rau kev tswj fwm ntawm ob peb koob tshuaj txhua txhua hnub, cov chaw muag tshuaj ntawm rosuvastatin tsis hloov pauv.
Nws tsis muaj qhov tshwj xeeb los kho rau kev noj ntau dhau ntawm rosuvastatin. Yog tias muaj kev noj ntau dhau, nws raug nquahu kom ua tiav cov kev mob tshwm sim thiab kev ntsuas txhawm rau tswj lub luag haujlwm ntawm cov kabmob thiab cov tshuab. Kev tshuaj xyuas ntawm lub siab ua haujlwm thiab qib Qib yog qhov tsim nyog. Hemodialysis tsis zoo li yuav ua haujlwm tau zoo.
Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom kev sib txuam tshuaj
Cov nyhuv ntawm kev siv ntawm lwm cov tshuaj ntawm rosuvastatin
Cov neeg tiv thaiv ntawm thauj cov protein: rosuvastatin khi rau qee cov thauj cov protein, tshwj xeeb, OATP1B1 thiab BCRP. Kev siv cov tshuaj tsis haum ntawm cov tshuaj tiv thaiv kab mob thauj no tej zaum yuav muaj nrog kev nce ntshav ntxiv ntawm rosuvastatin thiab muaj kev pheej hmoo ntawm myopathy (saib cov lus 3 thiab cov seem "Kev Siv thiab Cov Thawj Coj" thiab "Cov lus qhia tshwj xeeb").
Cyclosporin: nrog kev siv rosuvastatin thiab cyclosporine tib lub sijhawm, AUC ntawm rosuvastatin tau nruab nrab 7 lub sijhawm siab tshaj qhov pom nyob hauv cov neeg tuaj yeem noj qab haus huv (saib cov lus 3). Tsis cuam tshuam rau lub plasma concentration ntawm cyclosporine. Krestor ® sib kis rau cov neeg mob noj cyclosporine (saib Ntu "Kev Tshawb Fawb").
Kev Siv Tshuaj Tiv Thaiv Kab Mob (HIV) tiv thaiv cov tsis haum: txawm hais tias tus txheej txheem meej ntawm kev sib cuam tshuam yog tsis paub, kev tswj hwm ntawm HIV tiv thaiv cov neeg tiv thaiv kab mob tuaj yeem ua rau muaj qhov nce ntxiv rau rosuvastatin (saib cov lus 3).
Kev kawm pharmacokinetic ntawm kev siv tib lub sijhawm ntawm 20 mg ntawm rosuvastatip nrog kev sib koom ua ke npaj muaj ob tus kab mob HIV protease inhibitors (400 mg ntawm lopinavir / 100 mg ntawm ritonavir) hauv cov neeg tuaj yeem noj qab haus huv tau ua rau muaj kwv yees li ob npaug thiab tsib npaug ntawm AUC (0-24) thiab Cmax ntawm rosuvastatin, feem. Yog li ntawd, kev tswj hwm tib lub sijhawm ntawm rosuvastatin thiab HIV protease inhibitors tsis pom zoo (saib ntu "Dosage thiab Administration", "Cov Lus Qhia Tshwj Xeeb", cov lus 3).
Gemfibrozil thiab lwm yam tshuaj lipid: kev siv ua ke ntawm rosuvastatin thiab gemfibrozil ua rau kev nce siab 2 zaug hauv qhov siab tshaj plaws ntawm rosuvastatin hauv cov ntshav ntshav thiab AUC ntawm rosuvastatin (saib ntu "Cov lus qhia tshwj xeeb"). Raws li cov ntaub ntawv hais txog kev sib cuam tshuam tshwj xeeb, pharmacokinetically txoj kev sib cuam tshuam tseem ceeb nrog fenofibrate tsis xav tau, kev sib tham ntawm pharmacodynamic tau.
Gemfibrozil, fenofibrate, lwm cov fibrates, thiab lipid-txo cov koob tshuaj nicotinic acid nce qhov kev pheej hmoo ntawm myopathy thaum siv ua ke nrog HMG-CoA reductase inhibitors, tej zaum vim qhov tseeb tias lawv tuaj yeem ua rau myopathy thaum siv hauv kev kho mob monotherapy (saib ntu "Cov lus qhia tshwj xeeb") Cov. Thaum noj cov tshuaj nrog gemfibrozil, fibrates, nicotinic acid nyob rau hauv lipid qis tshuaj (ntau dua 1 g / hnub), cov neeg mob tau pom zoo kom pib cov koob tshuaj 5 mg, koob tshuaj 40 mg yog contraindicated nyob rau hauv nrog fibrates (saib ntu "Contraindications", " Dosage thiab administration "," Cov lus qhia tshwj xeeb ").
Ezetimibe: kev siv ib txhij ntawm cov tshuaj Krestor a ntawm ib koob ntawm 10 mg thiab ezetimibe ntawm ib koob tshuaj 10 mg tau nrog los ntawm kev nce ntxiv hauv AUC ntawm rosuvastatin hauv cov neeg mob hypercholesterolemia (saib cov lus 3). Nws yog tsis yooj yim sua kom cais tawm kev pheej hmoo ntawm kev phiv los ntawm kev sib raug zoo ntawm cov tshuaj sib tov ntawm cov tshuaj Krestor ® thiab ezetimibe.
Antacids: kev siv ib txhij ntawm rosuvastatin thiab kev ncua ntawm antacids uas muaj cov tshuaj magnesium thiab aluminium hydroxide, ua rau txo qis ntawm lub plasma concentration ntawm rosuvastatin los ntawm kwv yees li 50%. Cov nyhuv no tsis tshua pom zoo yog tias antacids siv 2 teev tom qab noj rosuvastatin. Cov kab mob tseem ceeb ntawm qhov kev sib txuam no tsis tau kawm.
Erythromycin: kev siv tib lub sijhawm rosuvastatin thiab erythromycin ua rau txo qis hauv AUC ntawm rosuvastatin los ntawm 20% thiab Cmax ntawm rosuvastatin los ntawm 30%. Xws li kev cuam tshuam tuaj yeem tshwm sim los ntawm kev mob plab hnyuv ntxiv los ntawm kev nqus ntawm erythromycin.
Cytochrome P450 Isofermeitis: cov txiaj ntsig hauv vivo thiab hauv kev tshawb fawb hauv vitro qhia tau hais tias rosuvastatin tsis yog ib qho inhibitor tsis yog qhov inducer ntawm isoenzymes ntawm cytochrome P450. Tsis tas li ntawd, rosuvastatin yog cov neeg tsis muaj zog rau cov isoenzymes no. Yog li no, kev sib cuam tshuam ntawm rosuvastatin nrog lwm cov tshuaj ntawm theem metabolic koom nrog cytochrome P450 isoenzymes tsis xav.
Tsis muaj kev cuam tshuam los ntawm kev kho mob tseem ceeb ntawm rosuvastatin nrog fluconazole (ib qho inhibitor ntawm isoenzymes CYP2C9 thiab CYP3A4) thiab ketoconazole (ib qho inhibitor ntawm isoenzymes CYP2A6 thiab CYP3A4).
Fusidic acid: cov kev tshawb fawb los kawm txog kev sib cuam tshuam ntawm rosuvastatin thiab fusidic acid tsis tau ua. Ib yam li lwm yam statins, cov ntaub ntawv tshaj tawm tom qab tshaj tawm ntawm rhabdomyolysis nrog kev sib koom tes ntawm rosuvastatin thiab fusidic acid tau txais. Nws yog ib qho tsim nyog los soj ntsuam cov neeg mob kom zoo. Yog tias tsim nyog, kev tshem tawm ib ntus ntawm rosuvastatin yog ua tau.
Kev cuam tshuam nrog cov tshuaj uas yuav tsum tau txhaj tshuaj ntawm rosuvastatin (saib cov lus 3)
Qhov ntau npaum li cas ntawm cov tshuaj Krestor ® yuav tsum tau hloov kho yog tsim nyog, nws txoj kev siv tshuaj ua ke nrog cov tshuaj uas ua rau muaj kev nce ntxiv nrog rosuvastatin. Koj yuav tsum nyeem cov lus qhia rau kev siv cov tshuaj no ua ntej lawv teem ua ke nrog tshuaj Krestor ®. Yog tias qhov nce ntxiv ntawm 2 zaug lossis ntau dua qhov xav tau, thawj zaug koob tshuaj tiv thaiv Crestor should yuav tsum tau 5 mg ib hnub ib zaug. Qhov siab tshaj plaws txhua hnub ntawm Krestor ® yuav tsum tau hloov kho kom qhov kev cia siab rau rosuvastatin tsis pub tshaj qhov ntawd rau ib koob tshuaj 40 mg noj tsis tas yuav tswj hwm cov tshuaj uas cuam tshuam nrog rosuvastatin. Piv txwv li, qhov siab tshaj plaws niaj hnub noj ntawm Crestor ® tshuaj nrog tib lub sij hawm siv nrog gemfibrozil yog 20 mg (nce ntxiv ntawm 1,9 zaug), nrog ritonavir / atazanavir - 10 mg (nce ntxiv yog 3.1 zaug).
Rooj 3 Cov. Cov nyhuv ntawm concomitant kev kho mob ntawm kev cuam tshuam nrog rosuvastatin (AUC, cov ntaub ntawv qhia nyob rau hauv kev txiav txim siab tsawg zuj zus) - cov txiaj ntsig ntawm kev soj ntsuam hauv kev soj ntsuam.
| Hom cuam tshuam kev kho mob | Txais hom rosuvastatin | Hloov AUC rosuvastatin |
| Cycloporin 75-200 mg 2 zaug ib hnub., 6 lub hlis. | 10 mg 1 zaug nyob rau ib hnub., 10 hnub | 7.1x nce |
| Atazanavir 300 mg / ritonavir 100 mg 1 lub sijhawm ib hnub., 8 hnub | 10 mg ib koob tshuaj | 3.1x nce |
| Simeprevir 152 mg 1 lub sijhawm ib hnub., 7 hnub | 10 mg ib koob tshuaj | 2.8x nce ntxiv |
| Lopinavir 400 mg / ritonavir 100 mg 2 zaug ib hnub., 17 hnub | 20 mg 1 zaug nyob rau ib hnub., 7 hnub | 2,1 npaug nce ntxiv |
| Clopidogrel 300 mg (chaw thau khoom noj) tom qab ntawd 75 mg tom qab 24 teev | 20 mg ib koob tshuaj | 2x nce |
| Gemfibrozil 600 mg 2 zaug ib hnub., 7 hnub | 80 mg ib koob tshuaj | 1.9x nce |
| Eltrombopag 75 mg 1 ib hnub. 10 hnub | 10 mg ib koob tshuaj | 1.6x nce |
| Darunavir 600 mg / ritonavir 100 mg 2 zaug ib hnub., 7 hnub | 10 mg 1 zaug nyob rau ib hnub., 7 hnub | 1.5 zaug nce ntxiv |
| Tipranavir 500 mg / ritonavir 200 mg 2 zaug ib hnub., 11 hnub | 10 mg ib koob tshuaj | 1,4 npaug nce ntxiv |
| Dronedarop 400 mg 2 zaug ib hnub. | Tsis muaj ntaub ntawv | 1,4 npaug nce ntxiv |
| Itraconazole 200 mg 1 lub sijhawm ib hnub., 5 hnub | 10 mg lossis 80 mg ib zaug | 1,4 npaug nce ntxiv |
| Ezetimibe 10 mg 1 lub sijhawm ib hnub., 14 hnub | 10 mg ib hnub ib zaug, 14 hnub | 1,2 npaug nce ntxiv |
| Fosamprenavir 700 mg / ritonavir 100 mg 2 zaug ib hnub., 8 hnub | 10 mg ib koob tshuaj | Tsis muaj hloov |
| Aleglitazar 0.3 mg. 7 hnub | 40 mg, 7 hnub | Tsis muaj hloov |
| Silymarin 140 mg 3 zaug ib hnub. 5 hnub | 10 mg ib koob tshuaj | Tsis muaj hloov |
| Fenofibrate 67 mg 3 zaug ib hnub., 7 hnub | 10 mg, 7 hnub | Tsis muaj hloov |
| Rifampin 450 mg Ib hnub. 7 hnub | 20 mg ib koob tshuaj | Tsis muaj hloov |
| Ketoconazole 200 mg 2 zaug ib hnub., 7 hnub | 80 mg ib koob tshuaj | Tsis muaj hloov |
| Fluconazole 200 mg 1 lub sijhawm ib hnub., 11 hnub | 80 mg ib koob tshuaj | Tsis muaj hloov |
| Erythromycin 500 mg 4 zaug ib hnub., 7 hnub | 80 mg ib koob tshuaj | 28% txo |
| Baikalin 50 mg 3 zaug ib hnub., 14 hnub | 20 mg ib koob tshuaj | 47% txo |
Cov nyhuv ntawm rosuvastatin ntawm lwm cov tshuaj
Antioxidists Vitamin K: kev pib ntawm rosuvastatin txoj kev kho lossis nce qhov koob tshuaj rau cov neeg mob uas tau txais tib lub sij hawm vitamin K kev tiv thaiv kab mob (piv txwv li warfarin) yuav ua rau muaj kev nce ntxiv hauv International Kev Sib Raug Zoo (MHO). Kev rho tawm ntawm rosuvastatin lossis txo qis ntawm cov tshuaj yuav tuaj yeem ua rau MHO txo qis. Hauv cov xwm txheej zoo li no, MHO tswj hwm pom zoo.
Kev kho qhov ncauj / tshuaj kho hloov: kev siv tib lub sijhawm rosuvastatin thiab tshuaj noj hauv qhov ncauj ua rau kom nce qhov AUC ntawm ethinyl estradiol thiab AUC ntawm norgestrel los ntawm 26% thiab 34%, feem. Xws li nce hauv plasma concentration yuav tsum tau coj mus rau hauv tus account thaum xaiv cov koob tshuaj tiv thaiv kab mob hauv qhov ncauj.
Cov ntaub ntawv pharmacokinetic ntawm kev siv ntau yam tshuaj Krestor ® thiab kev hloov kho tshuaj qog tsis tuaj, yog li ntawd, cov txiaj ntsig zoo sib xws tsis tuaj yeem tshem tawm nrog kev siv ntawm kev sib xyaw no. Txawm li cas los xij, qhov kev sib txuam no tau siv dav dav thaum sim kho mob thiab tau txais txiaj ntsig zoo los ntawm cov neeg mob.
Lwm yam tshuaj: tsis muaj kev sib cuam tshuam hauv cov chaw kho mob ntawm rosuvastatin nrog digoxin yog qhov xav tau.
Cov lus qhia tshwj xeeb
Cov teeb meem raum
Hauv cov neeg mob uas tau txhaj koob tshuaj Krestor high (feem ntau 40 mg), tubular proteinuria tau pom, uas feem ntau hloov chaw. Xws li cov proteinuria tsis tau qhia tias muaj cov kab mob hauv lub raum lossis kev loj hlob ntawm lub raum. Hauv cov neeg mob noj cov tshuaj ntawm ib koob ntawm 40 mg, nws raug nquahu kom soj ntsuam lub raum ua haujlwm thaum lub sijhawm kho.
Los ntawm cov leeg musculoskeletal
Thaum siv cov tshuaj Krestor ® hauv txhua qhov tshuaj, thiab tshwj xeeb tshaj yog thaum noj cov tshuaj ntau dua 20 mg, cov teebmeem hauv qab ntawm cov leeg mob tau qhia: myalgia, myopathy, hauv qee qhov mob tsawg, rhabdomyolysis.
Kev txiav txim siab ntawm creatine phosphokinase
Kev txiav txim siab ntawm CPK yuav tsum tsis txhob ua tom qab kev tawm dag zog lub cev lossis yog tias muaj lwm qhov laj thawj ntawm qhov nce hauv CPK, uas tuaj yeem ua rau tsis muaj tseeb los ntawm cov txiaj ntsig. Yog tias qib pib ntawm CPK tau nce siab (5 zaug ntau dua li qhov siab ntawm qhov tsis suav), kev ntsuas ntsuas yuav tsum tau ntsuas tom qab 5-7 hnub. Txoj kev kho yuav tsum tsis txhob pib yog tias kev rov ntsuas rov qhia dua qib pib ntawm CK (ntau dua 5 zaug siab dua qhov kev txwv siab tshaj ntawm ib txwm muaj).
Ua ntej pib txoj kev kho
Thaum sau tshuaj rau Krestor ®, zoo li thaum sau tshuaj rau lwm yam tshuaj tiv thaiv kab mob HMG-CoA reductase, yuav tsum ceev faj rau cov neeg mob uas muaj kev pheej hmoo rau myopathy / rhabdomyolysis (saib ntu "Ceev Faj"), nws yog qhov yuav tsum tau xav txog qhov kev pheej hmoo thiab qhov txiaj ntsig ntawm kev kho thiab soj ntsuam saib.
Thaum kho
Qhia rau tus neeg mob txog qhov yuav tsum tau qhia tus kws kho mob tam sim ntawd txog cov kev mob tshwm sim sai sai ntawm cov leeg mob, mob leeg tsis muaj zog lossis mob plab, tshwj xeeb tshaj yog ua ke nrog malaise thiab kub taub hau. Hauv cov neeg mob zoo li no, qib ntawm CPK yuav tsum txiav txim siab. Kev kho mob yuav tsum tsis ua haujlwm ntxiv yog tias CPK qib siab tau nce siab (ntau dua 5 zaug piv nrog kev txwv ntawm qhov tsis suav) lossis yog tias cov tsos mob ntawm cov leeg mob tau tshaj tawm thiab ua rau muaj kev tsis zoo nyob rau txhua hnub (txawm tias qib CPK 5 zaug qis dua lub zog sab sauv) ciam ntawm cov cai). Yog tias cov tsos mob ploj thiab qib CPK rov qab los nyob rau hauv ib txwm, kev txiav txim siab yuav tsum tau muab rau kev rov qab muab tshuaj Krestor ® lossis lwm qhov HMG-CoA reductase inhibitors hauv cov tshuaj qis dua nrog kev saib xyuas tus neeg mob kom zoo.
Kev tshuaj xyuas tsis tu ncua ntawm CPK thaum tsis muaj cov tsos mob tsis tuaj yeem ua.
Feem ntau tsis tshua muaj kev tiv thaiv kab mob hauv lub cev tiv thaiv neopotizing myopathy nrog cov kev kuaj mob hauv cov qauv ntawm qhov tsis muaj zog ntawm qhov tsis sib thooj thiab qhov nce ntawm qib ntawm CPK hauv cov ntshav cov ntshav thaum kho lossis thaum noj statins, suav nrog rosuvastatin, tau sau tseg. Cov kev kawm ntxiv ntawm cov leeg thiab cov leeg hlwb, kev tshawb fawb serological, nrog rau kev kho tshuaj tiv thaiv kab mob kuj yuav tsum tau ua.
Tsis muaj cov cim ntawm kev cuam tshuam ntawm cov leeg pob txha thaum noj Krestor ® thiab kho cov kev mob siab. Txawm li cas los xij, kev nce ntxiv ntawm qhov tshwm sim ntawm myositis thiab myopathy hauv cov neeg mob noj lwm yam tshuaj tiv thaiv kab mob, HMG-CoA reductase ua ke nrog fibric acid derivatives, suav nrog gemfibrozil, cyclosporin, nicotinic acid, azole antifungal agents, protease inhibitors thiab tshuaj tua kab mob macrolide, tau tshaj tawm. Gemfibrozil tsub kom muaj kev pheej hmoo ntawm myopathy thaum ua ke nrog qee yam HMG-CoA reductase inhibitors. Yog li, tib lub sijhawm tswj hwm ntawm cov tshuaj Krestor ® thiab gemfibrozil tsis pom zoo. Qhov sib piv ntawm kev pheej hmoo rau cov txiaj ntsig uas tsim nyog yuav tsum tau ntsuas kom zoo thaum siv Crestor together kev npaj ua ke nrog fibrates lossis lipid-txo cov koob tshuaj nicotinic acid. Kev siv cov tshuaj Krestor ® hauv ib koob tshuaj 40 mg ua ke nrog fibrates yog contraindicated. (saib tshooj "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm yam kev sib txuas lus ntawm kev siv tshuaj yeeb tshuaj", "Kev Tiv Thaiv Tsis Txaus").
2-4 lub lis piam tom qab pib kho thiab / lossis nrog kev nce ntxiv ntawm qhov koob tshuaj Krestor ® kev npaj, kev soj ntsuam cov lipid metabolism yog qhov tsim nyog (kev hloov kho koob tshuaj yog tsim nyog yog tias tsim nyog).
Lub siab
Nws raug nquahu kom txiav txim siab lub siab ua haujlwm kev ntsuas ua ntej pib kev kho thiab 3 lub hlis tom qab pib kho. Kev siv cov tshuaj Krestor ® yuav tsum tsis ua ntxiv lossis cov koob tshuaj yuav tsum tau txo yog tias theem ntawm transaminase kev ua haujlwm hauv cov ntshav cov ntshav yog 3 zaug ntau dua li cov kev txwv sab sauv ntawm ib txwm.
Hauv cov neeg mob hypercholesterolemia vim yog hypothyroidism los yog nephrotic syndrome, kev kho mob ntawm cov kab mob hauv qab yuav tsum tau nqa tawm ua ntej kev kho mob nrog Crestor ® tshuaj.
Tshwj xeeb cov neeg. Ib pawg haiv neeg
Hauv kev kawm ntawm cov kws kho mob ntawm cov neeg mob Suav thiab Nyij Pooj, kev nce ntxiv ntawm cov kab mob rosuvastatin tau muab piv nrog cov ntsuas tau ntawm cov neeg mob European (saib ntu "Kev Noj Tshuaj thiab Cov Thawj Coj" thiab "Pharmacokinetics").
Protease inhibitors
Kev siv tshuaj ua ke nrog cov tshuaj tiv thaiv protease inhibitors tsis pom zoo (saib ntu "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom kev sib cuam tshuam").
Lactose
Cov tshuaj yuav tsum tsis txhob siv rau hauv cov neeg mob uas tsis txaus lactase, galactose intolerance thiab glucose-galactose malabsorption.
Cov mob ntsws interstitial
Thaum siv qee yam statins, tshwj xeeb tshaj yog siv sijhawm ntev, qhia tawm cov xwm txheej ntawm tus mob ntsws interstitial. Kev tshwm sim ntawm tus kab mob tuaj yeem suav nrog ua pa siav, tsis hnoos tsis meej, thiab kev noj qab nyob zoo (tsis muaj zog, poob phaus, thiab kub cev). Yog tias xav tias tsam mob ntsws txawv ua ntej, kev kho mob statin yuav tsum tsis ua mus ntxiv.
Mob ntshav qab zib Hom 2
Hauv cov neeg mob uas muaj cov ntshav qabzib ntau nyob ntawm 5.6 txog 6.9 mmol / L, Kev Crestor ® kho tau cuam tshuam nrog kev pheej hmoo ntawm mob ntshav qab zib hom 2.
Cuam tshuam rau kev muaj peev xwm tsav tsheb loj thiab lwm yam txheej txheem
Tsis muaj kev tshawb fawb tau tshawb fawb txog qhov tshwm sim ntawm Krestor ® kev npaj rau lub peev xwm los tsav lub tsheb thiab siv cov twj siv. Txawm li cas los xij, raws li cov tshuaj pharmacodynamic zog, Krestor ® yuav tsum tsis muaj qhov tshwm sim zoo li no. Ceev faj yuav tsum tau siv thaum tsav tsheb lossis ua haujlwm ntsig txog kev ntseeg siab thiab cov kev xav ntawm lub hlwb (kiv taub hau yuav tshwm sim thaum kho).
Vim tias muaj cov roj (cholesterol) siab, kuv tus kws kho mob tau sau Krestor thaum xub thawj 5
Vim tias muaj cov roj (cholesterol) siab, kuv tus kws kho mob tau sau Krestor thaum xub thawj 5 mg, tom qab ntawd nce qhov koob tshuaj rau 10 mg. Cov kev ua tau zoo dua. Ntawm 3 lub xyoos, kev kuaj xyuas lub siab ua haujlwm tas li pom tias txhua yam ua tau raws li kev cai. Tom qab ntawd ib qho mob tshwm sim, cim los ntawm kub taub hau, mob nqaij, mob taub hau, tso zis tsaus ntuj, pw tsaug zog, tsis qab los. Tus kws kho mob xa mus rau kev soj ntsuam kom ntxaws - kev kuaj ntshav, duab xoo hluav taws xob, duab hluav taws xob thiab duab tom tom qab. Nws tau pom tseeb tias qhov ua rau tsis cuam tshuam nrog tus mob khaub thuas lossis mob khaub thuas. Thiab teeb meem nrog daim siab tau txheeb xyuas. Kuv tsis nres Crestor tam sim ntawd.
Tus ntoo khaub lig tau txo qis kuv cov roj thiab triglycerides. Tab sis kuv pom ib qho kev nce ntxiv
Tus ntoo khaub lig tau txo qis kuv cov roj thiab triglycerides. Tab sis kuv pom tias qhov hnyav nce, qaug zog, txo lub zog. Muaj mob hauv siab, mob hauv ob txhais tes, mob lub puab tsaig. Tus kws kho plawv tawm kev tshuaj xyuas thiab tsis txiav txim siab qhov ua rau muaj cov tsos mob no. Kuv tsum tsis haus Krestor, thiab hauv 2 rau 3 lub lis piam kuv qhov hnyav thiab qhov tsis zoo rov qab zoo li qub. Kuv tau nce kuv cov roj ntses ntau ntxiv, thiab tau mob siab rau kev noj haus. Kuv vam tias koj tsis tas yuav rov qab mus noj statins.
Kuv tau coj Krestor 10 mg rau ntau tshaj 10 xyoo. Nws tau ua txoj haujlwm zoo,
Kuv tau coj Krestor 10 mg rau ntau tshaj 10 xyoo. Nws tau ua txoj haujlwm zoo, txo kuv cov roj (cholesterol) mus rau qhov qub. Tab sis, tau ntau xyoo kuv tau mob rau mob txha, thiab cov kws kho mob tsis tuaj yeem piav qhia nws. Qee tus phooj ywg ntawm zaj dab neeg hais tias kuv qhov mob sib koom tes yuav yog los ntawm qhov kev nqis tes ntawm Krestor. Txhawm rau tshuaj xyuas nws qhov kev xav, kuv tau tso tseg tsis haus cov tshuaj. Thiab, ntawm chav kawm, tsuas yog tom qab ob peb hlis ua rau qhov mob sib txuas. Tam sim no kuv tsis kam lees Krestor ntxiv lawm.
Kuv haus 2,5 mg ntawm Crestor ib hnub (qhov no yog ib nrab ntawm 5 ntsiav tshuaj mg). Nws yeej tau qes
Kuv haus 2,5 mg ntawm Crestor ib hnub (qhov no yog ib nrab ntawm 5 ntsiav tshuaj mg). Qhov no tau txo qis kuv cov roj cholesterol ntawm 248 txog 193. Tsis yog qhov zoo, tab sis cov tshuaj txaus txaus. Kuv pib haus nrog 10 mg ib hnub, tab sis tau txais cov leeg mob thiab qhov nce siab ntawm daim siab enzymes.Tus kws kho mob tau hais kom kuv sim ua lwm yam statins, tab sis lawv txhua tus tib yam nkaus. Yog li, peb txo qis dua koob ntawm Crestor kom txog rau thaum cov kev mob tshwm sim. Nws ua haujlwm txig thiab tsis muaj kev cuam tshuam loj tshwm sim tam sim no tau pom.
Ntxiv rau kev ua ntshav qab zib, Kuv kuj muaj cov roj (ntsuas mob ntshav qab zib)
Ntxiv nrog rau kev ua ntshav qab zib, Kuv kuj muaj cov roj (ntsuas 12 xyoos dhau los). Kuv nyob ntawm kev txwv zaub mov, thiab tseem tsis noj qe thiab nqaij. Tab sis tseem, kuv cov cholesterol yog siab. Kuv tsis xav noj cov statins, vim tias kuv raug mob tawm pob ntau heev thaum kuv nqa lipitor. Tab sis lub caij ntuj sov dhau los, qhov ntsuas tau dhau los ua tsis zoo uas Krestor yuav tsum tau haus. Txawm li cas los xij, kuv pib nrog 5 mg ntau zaug hauv ib lub lim tiam. Tam sim no, 8 lub hlis tom qab, kuv cov roj hauv qab tau BELOW li qub thiab tag nrho lwm yam ntsuas tau dhau ntawm qhov zoo. Kuv tus kws kho mob endocrinologist tau txaus siab thiab tau hais tias tsis muaj laj thawj dab tsi ntxiv rau 10 mg. Yeej muaj tseeb, qee zaum kuv raug qee qhov mob nyob hauv cov pob qij txha hauv pob tes thiab pob taws, tab sis qhov no tiv taus.
Kev Sib Sau thiab daim ntawv ntawm kev tso tawm
Cov tshuaj nquag ntawm Krestor yog rosuvastatin. Cov tshuaj muaj pes tsawg leeg kuj suav nrog kev pabcuam: lactose, cellulose, magnesium stearate, calcium phosphate, thiab lwm yam. Crestor muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj liab, cov duab sib npaug npaj rau kev tswj hwm qhov ncauj. Raws li phau ntawv qhia radar, cov ntawv qhia Latin ua rau zoo li no: Rp.: Rosuvastatini 0.01 D.t.d.N.10 hauv tab.obd. S. 1–1.
Cov tshuaj muaj nyob rau hauv ntau qhov tshuaj:
- Crestor 5 mg
- Crestor 10 mg
- Crestor 20 mg
- Crestor 40 mg.
Nyob ntawm seb ntau npaum li cas, muaj cov ntawv sau rau ntawm ib sab ntawm lub ntsiav tshuaj. Piv txwv, ntawm qhov ntau npaum ntawm 10 mg, nws hais tias "ZD4522 10" rau nws. Cov ntsiav tshuaj muab tso rau hauv lub blister ntim ntawm 7 daim. Hauv ib pob ntawv cardboard tuaj yeem muaj 1, 4, 14 blisters.
Ntau zaus, qhov ntau npaum ntawm 10 mg yog yuav - 98 ntsiav tshuaj, uas yog, muaj 14 lub hlwv hauv pob. Muab qhov tseeb hais tias statins yog tshuaj rau lub sij hawm ntev siv, ntau tus neeg pom tias nws muaj txiaj ntsig yuav cov pob ntau heev hauv ib zaug.
Lub hauv paus ntsiab lus ntawm kev khiav haujlwm
Tus ntoo khaub lig yog lipid-qis tus neeg sawv cev, uas yog, lipid-qis dua. Nws cov txiaj ntsig tseem ceeb yog txhawm rau txo qis lipoproteins ntawm ntau qhov sib txawv hauv lub cev. Nkag mus rau daim siab - lub cev uas lub luag haujlwm tsim cov roj (cholesterol), rosuvastatin, cov tshuaj ua haujlwm ntawm cov tshuaj, muaj cov nyhuv inhibitory rau kev tsim cov lej ntawm cov enzymes.
Txawm li cas los xij, cov roj (cholesterol) nkag rau hauv cov ntshav tsis tsuas yog ua los ntawm lub siab. Ib feem ntawm cov khoom no nkag mus rau hauv lub cev nrog cov khoom noj, tshwj xeeb tshaj yog cov rog rog, zaub mov qua ntxi. Qhov kev txiav txim ntawm cov tshuaj pab ua kom ntxuav cov hlab ntshav ntawm cov lipoproteins uas tsis muaj ntau yam uas tau sau cia. Tus mob no yog hu ua thaum pib ntawm tus mob atherosclerosis.
Yog tias atherosclerosis twb tau pib tsim, cov hlab ntsha thiab cov hlab ntsha tau cuam tshuam los ntawm cov kab mob hauv cov cholesterol los yog plaques, Krestor muaj cov txiaj ntsig zoo rau lawv. Nws nkag rau hauv cov hlab dej, ntxuav lawv ntawm kev tso nyiaj. Vim qhov no, lumen hauv cov hlab ntsha thiab cov hlab ntsha nce ntxiv, cov ntshav ntws hauv thaj chaw muaj kev cuam tshuam normalizes.
Ib qho teeb meem ntawm atherosclerotic plaques yog thrombosis, uas hem ua rau lub ru tsev lossis txoj hlab ntsha tawg. Statins tiv thaiv qhov no los ntawm kev ua kom meej meej hauv lawv los ntawm kev txo qhov luaj li cas ntawm cov quav hniav.
Krestor belongs rau plaub tiam statins, pab pawg no suav hais tias yog qhov ua tau zoo tshaj plaws. Dhau li ntawm qhov tseeb tias nws cov kev npaj tau pab txo qis cov roj "tsis zoo" hauv cov ntshav, lawv tseem tuaj yeem tsim cov khoom "zoo". Cov roj (cholesterol) zoo yog lub hauv paus tseem ceeb rau kev ua haujlwm ntawm ntau cov kabmob hauv nruab nrog, kev tsim cov tshuaj hormones, ntxiv dag zog ntawm cov cell thiab lwm cov txheej txheem.
Cov lus qhia rau kev siv
Cov lus qhia txog kev siv tshuaj muaj nyob hauv txhua pob, nws yog ib qho tseem ceeb rau cov neeg mob kom lawv paub lawv tus kheej ua ntej noj tshuaj. Qhov ntau thiab cov kev coj noj coj ua tau muab tshuaj los ntawm tus kws kho mob tshwj xeeb. Feem ntau lub sijhawm pub dawb yog muab tshuaj, qhov tseem ceeb yog yuav tsum noj cov tshuaj txhua hnub tib lub sijhawm.
Raws li cov kws tshaj lij, ntau lub sijhawm yav tsaus ntuj yog qhov tsim nyog tshaj plaws rau noj cov tshuaj statins, txij thaum txog hnub kawg cov roj cholesterol hauv ntshav tau ntau dua thaum sawv ntxov.
Cov khoom lag luam yog npaj rau kev tswj hwm qhov ncauj, ntxuav nrog me me ntawm cov dej. Koj tsis tas yuav zom cov ntsiav tshuaj. Ua ntej txiav txim siab ntau npaum li cas, tus neeg mob tau sau ntawv rau kev soj ntsuam kom paub tseeb txog kev soj ntsuam cov kab mob ntawm cov hlab ntsha, ntshav hauv lub cev thiab cov kabmob ntawm cov hlab plawv.
Feem ntau kev muab tshuaj thawj zaug yog 10 mg. Ib hlis tom qab pib kev kho mob, tus neeg mob yuav tsum kuaj ntshav, thiab yog tias cov tshuaj muaj txiaj ntsig, tsis muaj kev cuam tshuam, kev noj tshuaj ntau ntxiv rau 20-40 mg ib hnub twg. Tom qab ntawd, thoob plaws tag nrho lub sijhawm kev kho mob, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam tas li kom ntsuas qhov tshwm sim thiab kho qhov ntau npaum li cas.
Yog tias cov tshuaj tau raug sau tseg rau kev tiv thaiv cov kab mob ntawm cov hlab plawv, cov tshuaj thawj zaug feem ntau yog 5 mg. Ua haujlwm dhau sijhawm, raws li kws kho mob tau cog lus, nws tuaj yeem ua kom nce ntxiv.
Feem ntau, cov tshuaj statins yog tshuaj rau lub neej, yog tias tsis yog, tom qab ntawd lub sijhawm lawv tau txais yog tsawg kawg yog 3-4 lub hlis. Koj tsis tuaj yeem txwv tsis pub noj tshuaj sai, tus kws kho mob tuaj yeem sau ib lub tswv yim raws li kev noj tshuaj txhua hnub yuav raug txo kom tsawg, thiab tsuas yog tom qab ntawd kev kho mob tuaj yeem nres.
Cov Yuav Tsum Muaj
Ib qho tshuaj twg hauv pawg statin muaj tus lej sib kis rau kev siv, txij li lawv suav hais tias yog muaj zog. Tus ntoo khaub lig tsis tuaj yeem siv rau cov cim no:
- hnub nyoog txog 18 xyoo
- cev xeeb tub thiab pub niam mis,
- tus kheej tsis kam mus rau rosuvastatin lossis lwm yam khoom xyaw uas muaj nyob hauv cov lus sib xyaw,
- kab mob siab mob thaum lub caij ua tsis zoo,
- mob hlwb
Rau cov neeg mob uas muaj pheej hmoo txhim kho myopathy, ib koob tshuaj ntawm 40 mg rau ib hnub yog contraindicated. Feem ntau lawv tau sau Crestor 20 mg lossis 10 mg ua ntej.
Thiab tseem yog cov tshuaj yog contraindicated rau hauv cov neeg mob noj ntau dhau haus cawv. Txij li qhov kev txiav txim ntawm statins yog feem ntau ua rau daim siab, yog tias nws raug kev txom nyem los ntawm co toxins ntawm cov dej cawv, nws yuav tsis tiv taus qhov siab. Yog tias tus neeg mob haus dej cawv nws haus cawv, hla ib chav ntawm kev kho kom zoo thiab rov zoo, kev kho tuaj yeem kho, tab sis yuav tsum pib nrog kev noj tshuaj tsawg.
Sab sij huam
Ntawm cov neeg mob noj Krestor, cov kev mob tshwm sim feem ntau tshwm sim hauv cov neeg uas tsis ua raws li kws kho mob cov lus pom zoo, tshaj li qhov noj lossis tsis quav ntsej cov cai ntawm contraindications. Cov kev mob tshwm sim muaj xws li:
- mob plab zom mov, mob plab,
- mob taub hau, kiv taub hau,
- hnov kev sib koom tes
- tawv nqaij ua pob, khaus,
- myalgia
- asthenia
- cov tsos ntawm puffiness.
Dab tsi yog qhov zoo dua Krestor lossis Rosuvastatin
Tus nqi nruab nrab ntawm rosuvastatin 20 mg 28 pcs. yog kwv yees li 550 rubles, thaum tus nqi rau Crestor yog yuav luag rau npaug ntxiv. Vim li no, ntau tus neeg mob nyiam xaiv cov kev xaiv pheej yig dua. Dab tsi yog qhov sib txawv ntawm cov tshuaj, tshwj tsis yog rau qhov sib txawv hauv tus nqi?
Krestor belongs rau cov statins ntawm plaub tiam kawg, thiab qhov no yog qhov tseem ceeb ntawm cov tshuaj. Nws yog qhov ua tau zoo, muaj kev nyab xeeb. Raws li ntau tus kws kho mob, yog tias koj pib noj cov tshuaj statins, thiab nws yuav siv sijhawm ntev, tej zaum rau lub neej, ces qhov no yuav tsum yog qhov tseem ceeb. Nws yog cov tshuaj no uas yog Krestor.
Cov txiaj ntsig ntawm Crestor, uas, tsis zoo li nws cov generics thiab hloov chaw ua pov thawj, suav nrog:
- cov nyhuv ceev
- siv tau yam tsawg kawg cov dos,
- txo kev pheej hmoo ntawm phiv.
Los txiav txim siab qhov twg yog qhov zoo dua rau kev noj nrog cov roj (cholesterol) siab, tus kws kho mob koom yuav pab, pom daim duab dav dav ntawm tus neeg mob.
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Ceg gymnastics rau cov ntshav qab zib
Ib cov kev tawm dag zog txhua hnub rau cov ntshav qab zib mellitus Hom 1 lossis ntshav qab zib hom 2 txhua xyoo yuav siv ntau lab tus tib neeg thoob plaws ntiaj teb. ... -
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