Xyuas rau Tevastor

Tevastor yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, zaj duab xis-txheej (10 pcs. Hauv cov hlwv, hauv ib daim npav los ntawm 3 lossis 9 hlwv):

• Qhov tshuaj 5 mg: puag ncig, biconvex, txua rau ntawm ib sab yog "N", nyob rau lwm sab yog "5", txheej zaj duab xis yog los ntawm lub teeb daj-txiv kab ntxwv mus rau txiv kab ntxwv (muaj xim zoo nkauj zoo nkauj) xim dawb
• qhov ntau thiab tsawg ntawm 10 mg: puag ncig, biconvex, txua rau ntawm ib sab yog "N", nyob rau lwm sab yog "10", zaj duab xis plhaub yog los ntawm lub teeb liab mus rau liab dawb, qhov tseem ceeb ntawm yuav luag dawb rau dawb yog qhov txawv ntawm qhov so,
• qhov ntau thiab tsawg ntawm 20 mg: puag ncig, biconvex, txua rau ntawm ib sab yog "N", nyob rau lwm sab yog "20", cov plhaub zaj duab xis yog los ntawm lub teeb liab mus rau liab dawb, qhov tseem ceeb ntawm yuav luag dawb rau dawb yog qhov txawv ntawm qhov so,
• qhov ntau thiab tsawg ntawm 40 mg: oval, txua rau ntawm ib sab yog "N", nyob rau lwm sab yog "40", zaj duab xis plhaub yog los ntawm lub teeb liab mus rau liab dawb, qhov tseem ceeb ntawm yuav luag dawb mus dawb yog qhov txawv ntawm qhov so.

1 ntsiav tshuaj hauv qhov ntau npaum ntawm 5 mg muaj:

• cov khoom xyaw nquag: rosuvastatin nyob rau hauv daim ntawv ntawm rosuvastatin calcium - 5.21 mg,
• Lub cev ntu: microcrystalline cellulose, lactose, povidone-KZO, crospovidone, sodium stearyl fumarate,
• Opadry II 85P23426 lub plhaub txiv kab ntxwv: titanium dioxide (E171), muaj qee cov dej cawv, polycyl cawv, talc, macrogol-3350, zas hlau oxide dub (E172), zas hlau oxide daj (E172), hnub poob hnub poob zas xim daj (E110).

1 ntsiav tshuaj hauv qhov ntau npaum 10, 20 lossis 40 mg muaj:

• cov khoom xyaw nquag: rosuvastatin nyob rau hauv daim ntawv ntawm calcium rosuvastatin - 10.42, 20.83 lossis 41.67 mg,
• Lub cev ntu: microcrystalline cellulose, lactose, povidone-KZO, crospovidone, sodium stearyl fumarate,
• casing Opadry II 85P24155 liab dawb: titanium dioxide (E171), qee cov kua dej polylyyl, talc, macrogol-3350, dyes - hlau oxide daj (E172), hlau oxide liab (E172), indigo carmine txhuas kua roj vanish (E132), azorubine txhuas cov kua roj vanish ( E 122).

Pharmacodynamics thiab pharmacokinetics

Tevastor yog tus muaj peev xwm sib tw HMG-CoA reductase nrog xaiv kev txiav txim. Nws ua rau daim siab. Cov tshuaj ua kom muaj zog ntxiv cov ntau hepatic LDL receptors thiab txhawb kev ntes thiab catabolism LDLCov. Nws ua rau inhibition ntawm synthesis VLDL, vim tias tag nrho cov naj npawb LDLthiab VLDL tsawg zuj zus.

Cov tshuaj txo cov ntshav nce hauv theem siab HS-tsis-HDL, HS-LDL, triglycerides, HS-VLDLP, TG-VLDLP, apolipoprotein B thiab tag nrho xckuj nce siab HS-HDL, apolipoprotein A-1Cov. Kuj tseem txo qhov piv:

• tag nrho xcthiabHS-HDL,
• HS-tsis-HDL thiab HS-HDL,
• apolipoprotein B thiab apolipoprotein A-1,
• HS-LDL thiab HS-HDL.

Cov nyhuv ntawm cov tshuaj yuav pom tau hauv thawj xya hnub tom qab pib ua haujlwm. Tom qab ob peb lub lis piam, 90% cov txiaj ntsig siab tshaj plaws tau tiav. 100% cov txiaj ntsig raug pom nyob rau thaum kawg ntawm lub hlis ntawm kev tswj hwm thiab raug tswj nrog kev siv tas mus li raws li cov lus qhia.

Qhov siab tshaj plaws ntawm kev ua kom nquag plias ntawm cov tshuaj hauv ntshav pom ze li 5 teev tom qab noj cov ntsiav tshuaj. Bioavailability yog li 20%.

Cov tshuaj ua ke ua ke tsuas yog ua rau lub siab. Kev sib txuas lus nrog cov protein ntshav yog kwv yees li 90%.

Qhov tseem ceeb isoenzymemetabolism hauv – CYP2C9Cov. Hauv biotransformation rosuvastatinyog tsim N-desmethyl thiab lactone metabolitesCov. Qhov tom kawg yog qhov chaw muag tshuaj. N-desmethyl txog ib nrab tsis tshua muaj siab ntseeg rosuvastatin.

Li ntawm 90% ntawm cov tshuaj ua kom nquag plias yog tawm tsis pauv hauv cov quav. Cov nyiaj seem uas teev tawm hauv zis. Qhov kev tshem tawm ib nrab-lub neej yog 19 teev. Nrog rau kev nce ntxiv hauv qhov ntau, nws tsis hloov.

Nyob rau hauv cov ntaub ntawv ntawm loj lub raum tsis ua hauj lwm cov ntsiab lus ntawm cov kev ua kom nquag plias hauv ntshav tau nce peb zaug, thiab qib N-desmethyl - cuaj lub sij hawm. Ntawm hemodialysis theem rosuvastatinhauv ntshav muaj li 50% siab dua.

Kev ntsuas rau siv

Cov tshuaj yog siv rau:

• thawjlossis sib xyaw hypercholesterolemiali qub hypertriglyceridemiaraws li kev txhais ntxiv rau kev noj haus, yog tias kev noj zaub mov noj thiab lwm yam kev kho mob tsis txaus,
• qhov xav tau ntawm kev tiv thaiv ua ntejkev mob plawv: plawv nres, arterial revascularization, mob stroke - thaum tus neeg mob laus tsis muaj cov tsos mob hauv tsev kho mob Ischemic mob plawv, tab sis muaj kev pheej hmoo ntawm nws tshwm sim, thiab tsawg kawg ib qho kev pheej hmoo yog tam sim no (thaum pib Ischemic mob plawv hauv tsev neeg keeb kwm, leeg ntshav siab, haus luam yeeb, txo qis HS-HDL),
• tsev neeg homozygous hypercholesterolemia raws li ib qho ntxiv tau txhais tau tias kev noj haus lossis lipid tejtxoj kev kho (nrog rau qee zaum uas tsis kho li ntawd),
• qhov xav tau kom qeeb kev loj hlob atherosclerosis raws li kev txhais ntxiv rau cov khoom noj muaj txiaj ntsig.

Cov Yuav Tsum Muaj

Kev ua txhaum ntawm kev siv tshuaj yuav txawv raws li kev siv ntau npaum cas.

Rau cov ntsiav tshuaj ntawm 5-20 mg, cov nram qab no contraindications muaj:

• nquag ua daim siab mob
• intolerance lactose,
• mob raum tsis zoo,
• kev pub mis,
• piam thaj galactose malabsorptionLactase tsis muaj zog
• cev xeeb tub,
• kev tiv thaiv tsis haummus rau lub Cheebtsam ntawm cov txhais tau tias,
• mob rau daim siab mob hnyav (tsis tau kawm),
• mob hlwb,
• tsis muaj txoj hauv kev ntawm kev tiv thaiv kev tiv thaiv kev xeeb tub,
• cov me nyuam hnub nyoog qis dua 18 xyoo

40 mg ntsiav tshuaj tsis tuaj yeem siv rau hauv cov teeb meem hauv qab no:

• nquag ua daim siab mob
• lactose intolerance,
• muaj cov yam txaus ntshai myopathies lossis rhabdomyolysis(myotoxicitythaum siv HMG-Co-A-reductase inhibitors lossis fibrate hauv keeb kwmtus kheej lossis tsev neeg tsom xam cov leeg mob, lub raum tsis ua hauj lwmnquag haus hypothyroidism, cov xwm txheej ua rau cov ntsiab lus nce ntxiv rosuvastatinhauv ntshav)
• cev xeeb tub,
• tsis muaj txoj hauv kev muaj txiaj ntsig zoo tiv thaiv kev tiv thaiv kev xeeb tub ntawm tus menyuam,
• kev pub mis,
• cov me nyuam hnub nyoog qis dua 18 xyoo
• kev tiv thaiv tsis haumrau lub Cheebtsam ntawm cov tshuaj,
• mob ua rau daim siab mob hnyav,
• piam thaj galactose malabsorptionLactase tsis muaj zog
• Neeg Asia.

Nrog kev ceev faj, cov ntsiav tshuaj ntawm 5-10 mg yuav tsum tau noj los ntawm cov neeg mob ntawm haiv neeg Esxias, yog tias muaj kev pheej hmoo rau myopathies/rhabdomyolysis, cov neeg laus dua 65 xyoo, thiab tseem mob rau daim siab mob hauv keeb kwmkev raug mob arterial hypotensioncov mob endocrine hnyav, qhov xwm txheej ua rau cov ntsiab lus nce ntxiv rosuvastatinhauv ntshav sepsishnyav metabolickev ua txhaum cai, kev phais mob dav ntxiv, kev tswj tsis tau chua leeg, mob hnyav electrolytekev ua txhaum.

40 mg ntsiav tshuaj yog siv nrog ceev faj hauv daim siab mob hauv keeb kwm, lub raum tsis ua hauj lwm, arterial hypotension, kev raug mob, mob hnyav endocrine, lub hnub nyoog ntawm 65 xyoo, sepsishnyav metabolickev ua txhaum cai, kev phais mob dav ntxiv, kev tswj tsis tau chua leeg, mob hnyav electrolyte kev ua txhaum.

Cov lus qhia rau kev siv Tevastor (Txujci thiab ntau npaum li cas)

Cov ntsiav tshuaj noj ntawm qhov ncauj. Txhawm rau pib kho, kev noj tshuaj txhua hnub ntawm 10 mg yog qhov kev pom zoo. Yog tias tsim nyog, tom qab ib hlis nws tuaj yeem nce ntxiv rau 20 mg. Ib cov tshuaj hauv qhov tshuaj ntawm 40 mg yuav tsum tau noj nyob rau hauv kev saib xyuas nruj los ntawm tus kws tshaj lij, vim tias muaj kev pheej hmoo siab ntawm kev phiv. Cov lus qhia rau kev siv Tevastor qhia tau hais tias noj 40 mg ntsiav tshuaj yog ua tau tsuas yog thaum muaj mob hnyav hypercholesterolemiathiab qhov muaj peev xwm siab kev mob plawvthaum kev noj tshuaj 20 mg rau ib hlis tsis zoo txaus. Nrog rau kev nce ntxiv hauv cov tshuaj, ntxiv rau tom qab 2-4 lub lis piam ntawm kev noj tshuaj, nws yog ib qho tsim nyog los soj ntsuam cov ntsuas ntawm cov rog rog.

Cov lus qhia rau kev siv Tevastor tshaj tawm tias kev txais tos yog ua tau txhua lub sijhawm thiab tsis hais zaub mov dab tsi. Cov tshuaj yog nqos tau tag nrho, ntxuav nrog ib qho me me ntawm cov kua, tsis tas yuav zom. Nws tsis yooj yim sua kom zom cov ntsiav tshuaj, tsuas yog tias nws yog qhov yuav tsum tau noj ntau npaum li 5 mg, ib ntsiav tshuaj 10 mg tuaj yeem faib ua ob zaug.

Thaum kho nrog Tevastor, yuav tsum pom kev noj zaub mov kom tsis txhob mob siab.

Thaum muaj hnub nyoog nto 65 xyoos, cov neeg mob nrog noob polymorphism SLC01B1, cov neeg ntawm cov haiv neeg Asian, zoo li muaj qee yam mob me me rau lub raum, nws raug nquahu kom pib noj cov qis qis kawg nkaus ntawm 5 mg.

Cov neeg mob nrog rau cov ntsiab lus taw qhia qhov txawv txav mus rau myopathies, Thaum pib ntawm qhov pib koj yuav tsum tau noj 5 mg. Maj mam, cov koob tshuaj nce ntxiv txog 10-20 mg.

Noj ntau dhau

Kev siv tib lub sij hawm ntau ntawm cov tshuaj txhua hnub tsis ua rau muaj kev hloov pauv hauv cov txheej txheem pharmacokinetic rosuvastatin.

Kev kho rau ib qho overdose yog tsos mob. Nws yog ib qho tsim nyog los soj ntsuam daim siab ua haujlwm thiab kev ua haujlwm KFKCov. Tshwj Xeeb tshuaj tiv thaiv kab mob tsis muaj nyob.

Kev sib txuam

Thaum muab sib xyaw nrog kev thaiv kevVitamin K yuav tsum tau tswj INR, txij li tau nce ntxiv ntawm cov tshuaj tuaj yeem ua rau nce ntxiv INR thiab prothrombin lub sijhawm, thiab kev txiav tsis noj tshuaj lossis txo qis kev noj tshuaj rau, ua rau, INR.

Sib cuam tshuam nrog Gemfibrozil nce cov ntsiab lus rosuvastatinhauv ntshav 2 zaug.

Teem sijhawm nrog tshuaj tiv thaiv kab mobsuav nrog txhuas thiab magnesium hydroxideua rau poob qis hauv qib rosuvastatinnyob rau hauv ntshav los ntawm 50%. Cov nyhuv tsis tshua pom zoo yog tias koj soj ntsuam lub caij nyoog nruab nrab ntawm lawv qhov kev ncua ntawm 2 teev.

Erythromycin provokes ib tug txo AUC rosuvastatin los ntawm 20%. Tsis tas li ntawd xwb, qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw no txo ​​los ntawm 30%.

Txais tos qhov ncauj tiv thaivcov nyiaj nce ntxiv AUC norgestrel thiab ethinyl estradiol, ntsig txog, los ntawm 26% thiab 34%.

Qhov peev xwm ntawm kev loj hlob myopathiesnce thaum noj lipid-txoskoob tshuaj nicotinic acid thiab fibratethiab kev siv tib txhij HMG-CoA reductase inhibitorsCov. Siv 40 mg tshuaj tib lub sijhawm fibrates contraindicated.

Cov neeg nyob hauv protease ua rau muaj kev nce siab nyob rau hauv qhov siab tshaj plaws ntawm cov kev nquag ntawm Tevastor los ntawm 5 zaug. Kev sib xyaw ua ke no tsis pom zoo.

Koj tsis tuaj yeem xyaw Tevastor thiab Cyclosporin vim yog qhov tshwm sim muaj txoj kev loj hlob myopathiesCov. Yog tias kev sib txig sib luag ntawm cov nyiaj no tsis tuaj yeem zam, nws raug nquahu kom tsis pub ntau tshaj 5 mg rau ib hnub.

Analogs ntawm Tevastor

Cov Tevastor analogues hauv qab no paub, uas cov khoom sib xyaw ua ke thiab daim ntawv tso tawm tso tawm:

Txhua tus ntawm lawv tus kheej muaj cov yam ntxwv ntawm kev siv thiab yuav tsum tsis txhob siv yam tsis muaj daim ntawv sau los ntawm kws kho mob.

Tevastor feem ntau pom zoo hauv khw muag tshuaj thaum tib neeg tig mus rau cov nqi sib tw kim dua. Rau kev sib piv, tus nqi ntawm cov tshuaj nrov Neeg Coob10 mg - txog 1300 rubles. Tib lub sijhawm, tus nqi ntawm Tevastor 10 mg yog 470 rubles.

Cov Tshuaj Pharmacokinetics

Pharmacokinetic cov yam ntxwv ntawm rosuvastatin:

• kev nqus: kev ua tiav ntawm Cmax (qhov siab tshaj plaws) hauv cov ntshav ntshav tshwm sim kwv yees li 5 teev tom qab kev noj tshuaj ntawm qhov ncauj, qhov taw qhia txog qhov txheeb tau ntawm bioavailability yog kwv yees li 20%,
• kev faib tawm: txog li 90% ntawm rosuvastatin khi rau cov ntshav plasma, kom ntau dua nrog albumin, cov khoom ntim ntau hauv daim siab (cov khoom hauv lub cev tseem ceeb rau kev sib txuas ntawm Xc thiab catabolism ntawm Xs-LDL), cov khoom faib (Vd) yog kwv yees li 134 l,
• cov metabolism: rosuvastatin biotransforms me ntsis (txog 10% ntawm lub koob tshuaj noj), vim nws yog qhov tsis muaj txheej txheem tsis khov hauv cov txheej txheem metabolic ntawm enzymes ntawm cytochrome P450 system. CYP2C9 ua raws li lub ntsiab isoenzyme koom nrog hauv cov metabolism hauv ntawm rosuvastatin. Txhawm rau qis dua, isoenzymes CYP2C19, CYP3A4 thiab CYP2D6 tau koom tes nrog txoj hauv kev. Lub ntsiab txheeb pom cov metabolites ntawm rosuvastatin: N-dismethyl - nws qhov kev ua si yog ib nrab ntawm rosuvastatin, lactone metabolites - uas yog cov tshuaj pharmacologically tsis ua haujlwm. Kev txwv tsis pub nthuav tawm ntawm HMG-CoA reductase nyob rau hauv ntau dua 90% yog tau lees paub los ntawm pharmacological kev ua si ntawm rosuvastatin, tus so los ntawm nws cov metabolites,
• kev tshem tawm: ib nrab-lub neej (T_1/2) yog kwv yees li 19 teev .Tus nqi ntawm T_1/2 tsis hloov nrog nce dua koob tshuaj. Txog li 90% ntawm cov tshuaj yog ua tiav nrog quav quav tsis txawv txav, cov khoom seem ua paug nyob hauv cov zis. Qhov nruab nrab ntshav ntshav tshem tawm

50 l / h (nrog coefficient ntawm kev sib txawv - 21.7%). Tus kab mob hepatic ntawm rosuvastatin, zoo li lwm tus neeg tiv thaiv kab mob HMG-CoA reductase, muaj feem xyuam nrog anionic membrane cab Xc, uas muaj lub luag haujlwm tseem ceeb hauv kev tshem tawm hepatic ntawm cov tshuaj yeeb dej caw.

Pharmacokinetics ntawm rosuvastatin hauv pawg neeg mob tshwj xeeb:

• lub raum tsis ua haujlwm: mob me thiab mob pes tsawg - qhov ntsuas ntawm lub plasma concentration ntawm rosuvastatin thiab N-dysmethyl tsis hloov pauv, qhia tau meej, nrog creatinine tshem tawm (CC) tsawg dua 30 ml / min, - ntshav plasma concentration ntawm rosuvastatin yog 3 zaug dua, nws nquag metabolite, N -dismethyl, 9 zaug ntau dua, thiab nyob rau hauv cov neeg mob ntawm hemodialysis tus nqi yog kwv yees li 50% siab dua hauv cov neeg tuaj yeem noj qab haus huv,
• mob siab rau lub siab (cov qhab nia ntawm Child-Pugh nplai): ≤ 7 cov ntsiab lus - nce hauv T_1/2 tsis kuaj pom, 8 --9 - tsawg kawg 2 tus neeg mob tau nce hauv T_1/2tsawg kawg 2 zaug, ≥ 9 - tsis muaj kev paub nrog kev siv,
• haiv neeg: Cov neeg Nyij Pooj thiab cov neeg Suav nyob hauv Asia qhia thaj tsam thaj tsam ob npaug ntawm thaj tsam nruab nrab nyob rau hauv thaj chaw nruab nrab (AUC), piv nrog cov nqi rau cov neeg mob ntawm cov haiv neeg nyob sab Europe thiab Asia. Kev cuam tshuam ntawm caj ces cov yam ntxwv thiab ib puag ncig ntawm cov kev txawv no hauv cov qauv pharmacokinetic tsis tau pom. Kev soj ntsuam ntawm cov pab pawg neeg sib txawv ntawm cov neeg mob: Neeg Mev, Cov Neeg European, cov neeg tawv dub, Neeg Asmeskas Dub - tsis tau qhia tawm qhov sib txawv hauv cov chaw muaj tshuaj txawv,
• lub hnub nyoog thiab poj niam txiv neej: tsis muaj qhov tseem ceeb hauv kev siv tshuaj rau tus yam ntxwv ntawm rosuvastatin.

5 mg, 10 mg thiab 20 mg ntsiav tshuaj

• mob siab ua rau lub siab ua haujlwm zoo (≥ 9 cov ntsiab lus ntawm Me-Pugh nplai), vim tsis muaj kev paub dhau los ntawm kev siv,
• mob siab rau hauv cov theem nquag, suav nrog kev nce ntxiv hauv kev ua haujlwm ntawm daim siab enzymes lossis nce ntau dua 3 zaug hauv qhov sib piv nrog kev txwv siab dua ntawm ib txwm muaj (VGN),
• Kev mob raum tsis zoo (CC 60 ml / min), keeb kwm muaj kab mob siab, mob sepsis, mob ntshav tawm ntshav, kev phais mob ntau ntxiv, kev raug mob, teeb meem loj ntawm lub cev, endocrine lossis hluav taws xob tsis sib haum xeeb, tswj tsis tau tus mob, thiab rau cov neeg laus dua 65 xyoo.

Cov lus qhia rau kev siv Tevastor: txoj kev thiab ntau npaum li cas

Tevastor yog npaj rau kev tswj hwm qhov ncauj. Cov ntsiav tshuaj yuav tsum tsis txhob zom thiab tsoo, lawv yuav tsum nqos tag nrho thiab ntxuav nrog dej. Yog tias koj xav noj rosuvastatin ntawm ib koob ntawm 5 mg, ib ntsiav tshuaj ntawm koob tshuaj 10 mg yuav tsum muab faib ua ib nrab. Qhov tshuaj rau noj yog ywj siab ntawm lub suab circadian, nrog rau kev noj haus.

Ua ntej noj Tevastor, tus neeg mob yuav tsum pib ua raws li kev noj zaub mov zoo lipid-txo qis, uas yuav tsum tau txuas ntxiv thoob plaws kev kho mob.

Cov koob tshuaj ntawm rosuvastatin raug xaiv ib tus zuj zus thiab nyob ntawm qhov ntsuas kev kuaj mob thiab kho cov lus teb ntawm tus neeg mob, suav txog cov lus pom zoo tam sim no ntawm cov qib lipid.

Rau cov neeg mob pib noj cov tshuaj, lossis hloov pauv los ntawm noj lwm qhov HMG-CoA reductase inhibitors, qhov pib koob tshuaj 5 lossis 10 mg ib hnub ib zaug pom zoo. Nws txoj kev xaiv yog nyob ntawm cov roj (cholesterol) thiab cov muaj feem yuav ua mob plawv thiab muaj feem tshwm sim. Yog tias tsim nyog, tom qab 4 lub lis piam koob tshuaj Tevastor tuaj yeem raug nce ntxiv.

Thaum muaj mob hypercholesterolemia thiab muaj kev pheej hmoo siab heev ntawm cov hlab plawv (tshwj xeeb tshaj yog nyob rau cov neeg mob nrog tsev neeg hypercholesterolemia), thaum cov txiaj ntsig xav tau tsis tiav nrog kev kho mob rosuvastatin ntawm kev noj tshuaj ntawm 20 mg rau 4 lub lis piam, koob tshuaj yuav tsum tau nce rau 40 mg nyob rau hauv kev saib xyuas ntawm kws kho mob ( vim tias muaj kev pheej hmoo ntawm qhov tshwm sim tsis zoo). Cov neeg mob uas tau txais 40 mg ntsiav tshuaj yuav tsum tau saib xyuas kom zoo. Tom qab nce qhov koob tshuaj thiab / lossis 2-4 lub lis piam ntawm kev noj Tevastor, nws yog ib qhov tsim nyog los soj qab cov lipid metabolism.

Cov neeg mob rau cov haiv neeg Esxias, nws raug pom zoo kom pib kho nrog Tevastor nrog koob tshuaj 5 mg, ntsiav tshuaj hauv qhov ntau npaum li 40 mg yog contraindicated.

Tsis txhob noj Tevastor hauv ib koob ntawm 40 mg rau cov neeg mob uas nrog lub siab xav rau txoj kev txhim kho myopathy, thiab thaum sau ntawv 10 thiab 20 mg ntsiav tshuaj, nws raug nquahu kom pib kho nrog koob tshuaj 5 mg.

Cov tshuaj tua hluav taws xob hauv nruab nrog cev: muaj cov tsheb thauj khoom ntawm genotype SLC01B1 (OATP1B1) s.521CC thiab keeb kwm ABCG2 (BCCR) C.421AA muaj kev cuam tshuam ntau dua (AUC) rau rosuvastatin piv rau cov nqa khoom ntawm genotype SLC01B1 C.521TT thiab genotype ABCG2 s.421CC. Yog li, rau cov neeg mob nqa tshuaj genotypes c.521SS thiab C.421AA, nws raug nquahu kom noj Tevastor ib hnub ib zaug ntawm qhov siab tshaj 20 mg.

Vim kev khi ntawm rosuvastatin mus rau ntau cov kis thauj khoom (piv txwv li OATP1B1 thiab BCRP), kev siv Tevastor tib lub sijhawm nrog cyclosporine thiab HIV protease inhibitors (suav nrog ritonavir hauv kev sib xyaw nrog atazanavir, lopinavir) ua rau muaj kev pheej hmoo ntawm myopathy / rhabdomyolysis. Uas yuav tsum tau txiav txim siab txog qhov muaj peev xwm ntawm lwm txoj kev kho lossis txiav txuas ib ntus ntawm cov tshuaj. Yog tias nws tsis tuaj yeem zam kom tsis txhob muaj kev siv ntau yam ntawm cov tshuaj no, nws yog ib qho tsim nyog los soj ntsuam cov txiaj ntsig / kev pheej hmoo ntawm kev sib xyaw nrog txoj kev kho thiab txiav txim siab txo qhov koob tshuaj Tevastor.

Sab sij huam

Cov kev mob tshwm sim uas pom nrog rosuvastatin feem ntau yog mob me me thiab hloov, thiab qhov ntau zaus ntawm lawv tshwm sim, ib yam li lwm yam HMG-CoA reductase inhibitors, yog feem ntau koob tshuaj.

Qhov ntau zaus ntawm cov kev mob tshwm sim los ntawm cov chav kawm hauv lub cev (ntawm qhov ntsuas: ntau dua li 1/100, tab sis tsawg dua 1/10 - feem ntau, ntau dua li ntawm 1/1000, tab sis tsawg dua 1/100 - ua tsis tau, ntau dua li 1/10 000, tab sis tsawg dua 1/1000 - tsis tshua muaj, tsawg dua li 1/10 000 - tsis tshua muaj nqi, nws tsis yooj yim sua kom suav raws li muaj cov ntaub ntawv muaj - tus zaus tsis paub):

• kev tiv thaiv kab mob: tsis tshua muaj - kev ua kom tsis haum lub cev, mus txog angioedema,
• endocrine system: feem ntau - hom 2 mob ntshav qab zib mellitus,
• cov hlab ntsha hauv nruab nrab: feem ntau - kiv taub hau, mob taub hau,
• plab zom mov: feem ntau - xeev siab, cem quav, mob plab, tsis tshua muaj - kab mob pancreatitis,
• tawv nqaij thiab nqaij rog tuaj yeem: ua haujlwm ntxau dhau - ua pob ua pob, khaus khaus, tawv tsaj,
• cov musculoskeletal system: feem ntau - myalgia, tsis tshua muaj - myopathy (suav nrog myositis), mob rhabdomyolysis, kev siv Tevastor hauv txhua qhov tshuaj (tshwj xeeb tshaj 20 mg) - myalgia, myopathy (suav nrog myositis), muaj qee yam - rhabdomyolysis nrog / tsis mob raum tsis ua haujlwm, koob tshuaj tiv thaiv kab mob nce ntxiv hauv kev ua si ntawm creatine phosphokinase (CPK), nyob rau hauv feem ntau tshwm sim - me ntsis, asymptomatic thiab ib ntus. Nrog rau kev nce VGN ntawm kev ua haujlwm ntawm CPK los ntawm 5 zaug lossis ntau dua, kev kho mob nrog rosuvastatin yuav tsum tau txiav tawm ib ntus,
• qhov system urinary: proteinuria - cov kev hloov pauv tseem ceeb ntawm cov protein nyob hauv cov zis (txij li qhov qhaj tag los yog muaj cov lw seem rau ++ lossis ntau dua) tau sau tseg tsawg dua 1% ntawm cov neeg mob tau txais 10-20 mg ntawm rosuvastatin, thiab

3% tau txais koob tshuaj 40 mg. Rau feem ntau, cov proteinuria txo qis lossis ploj thaum kho thiab tsis ua rau exacerbation lossis kev loj hlob ntawm ib qho mob raum,

Tus zaus ntawm kev mob tshwm sim ntawm Tevastor raws li kev thov tom qab muag kev lag luam:

• ntshav thiab lymphatic system: zaus tsis paub - thrombocytopenia,
• plab zom mov: tsis tshua muaj - nce kev ua si ntawm daim siab enzymes, tsis tshua muaj - kab mob daj ntseg, kab mob siab, ntau zaus tsis paub - raws plab,
• musculoskeletal system: tsis tshua muaj tshwm sim - arthralgia, tsis paub zaus - immuno-mediated necrotizing myopathy,
• lub hauv nruab nrab hauv lub paj hlwb: tsis tshua muaj - polyneuropathy, nco ploj.
• tus kab mob ua pa: ntau zaus uas tsis paub - ua tsis taus pa, hnoos,
• qhov system urinary: tsis tshua muaj mob - hematuria,
• daim tawv nqaij thiab roj tuaj yeem sib txawv: tsis paub ntau - Stevens-Johnson syndrome,
• kev muaj me nyuam: tsis paub ntau heev - gynecomastia,
• lwm cov kev cuam tshuam: ntau zaus tsis paub - peripheral edema.

Cov kev mob tshwm sim hauv qab no tau pom vim siv qee yam statins: kev sib daj sib deev, kev nyuaj siab, pw tsaug zog (suav nrog insomnia thiab npau suav phem), nyob rau hauv cov teeb meem raug rho tawm - mob ntsws interstitial, tshwj xeeb tshaj yog vim kev siv tshuaj ntev.

Xyuas txog Tevastor

Kev txheeb xyuas txog Tevastor feem ntau yog qhov zoo. Cov neeg uas noj cov tshuaj no nco ntsoov tias nws normalizes qib roj tom qab txog 3 lub lim tiam los ntawm pib ua thawj coj.

Kev tshuaj xyuas ntawm cov kws kho mob hais txog Tevastor kuj tseem muaj qhov zoo. Lawv feem ntau pom zoo cov tshuaj Israeli no ua ib qho tshuaj tiv thaiv kom kim Tus qau.

Txo Cov Roj Cholesterol Nrog Tevastor

Zhuravlev Nikolay Yuryevich

Tevastor yog ib hom tshuaj uas yog koom nrog pab pawg ntawm statins thiab pabcuam rau txo cov tshuaj ntsiab lus ntawm cov roj lipoproteins tsawg dua, thiab tseem yuav txo cov roj ntshav cov roj.

Cov khoom siv tseem ceeb ntawm Tevastor yog rosuvastatin. Cov tshuaj ua haujlwm li cas?

Nws paub tias hauv tib neeg lub cev muaj cov rog uas cuam tshuam tsis zoo rau nws kev noj qab haus huv: lawv txiav txim siab rau ntawm cov phab ntsa ntawm cov hlab ntshav, ua cov plaques, hamper cov nqaij noj haus thiab lub siab ua haujlwm.

Kev Kho Mob nrog Tevastor yog tsom rau kev cuam tshuam rau daim siab, qhov twg, qhov tseeb, qhov tshwm sim ntawm kev tawg ntawm cov rog (lipoproteins) tshwm sim.

Cov tshwm sim thawj zaug pom ntawm kev kho mob nrog cov tshuaj no tshwm nyob rau ib lub lim tiam tom qab pib siv tshuaj, thiab ib hlis tom qab koj tuaj yeem ntsuas qhov siab tshaj plaws.

Txhawm rau soj ntsuam, kev ntsuam xyuas ntshav tsis tu ncua, ua kom pom qhov kev hloov pauv hauv cov ntshav ntawm ntau hom lipoproteins.

Ntxiv nrog rau qhov kev cuam tshuam hypolipidemic, rosuvastatin muaj cov txiaj ntsig zoo ntawm endothelial kawg (uas tau sau tseg raws li lub cim preclinical ntawm qhov tshwm sim ntawm thaum ntxov atherosclerosis), txhim kho rheological cov khoom ntawm cov ntshav (fluidity), thaum muaj cov tshuaj tiv thaiv kabmob thiab antioxidant.

Cov lus qhia tshwj xeeb

Proteinuria, feem ntau ntawm keeb kwm raum, raug kuaj thaum kuaj, raug pom nyob hauv cov neeg mob noj cov tshuaj ntawm 40 mg los yog siab dua, feem ntau nws hloov mus rau hauv cov xwm txheej thiab tsis yog cov tsos mob ntawm kev vam meej lossis mob raum tsis ua haujlwm. Txhua qhov mob raum tseem ceeb tau sau tseg thaum noj rosuvastatin ntawm ib koob ntawm 40 mg, yog li kev siv Tevastor ntawm ib koob ntawm 40 mg yuav tsum tau saib xyuas kev ua haujlwm ntawm lub raum.

Cov nqaij mob pob txha mos muaj xws li mob myalgia, myopathy, thiab, tsis tshua muaj mob rhabdomyolysis, tau pom nyob hauv cov neeg mob noj Tevastor ntawm koob tshuaj 20 mg lossis ntau dua. Cov huab cua tsis tshua muaj neeg kaw tseg ntawm rhabdomyolysis nrog kev siv sib xyaw ntawm ezetimibe thiab HMG-CoA reductase inhibitors. Kev pheej hmoo ntawm rhabdomyolysis, ob qho tib si nrog rosuvastatin txoj kev kho thiab nrog lwm HMG-CoA reductase inhibitors, nce ntxiv nrog ib koob ntawm 40 mg.

Kev ua haujlwm ntawm CPK yuav tsum tsis txhob txiav txim siab tom qab kev tawm dag zog lub cev, nrog rau lwm qhov laj thawj rau qhov nce ntxiv hauv nws cov haujlwm vim qhov yuav cuam tshuam ntawm cov ntsuas. Thaum pib ua haujlwm ntawm CPK tau nce siab (≥ 5 VGN), tom qab 5-7 hnub nws yog qhov tsim nyog los ntsuas qhov ntsuas. Koj yuav tsum tsis txhob pib noj Tevastor yog tias qhov kev kuaj xyuas zaum ob pom tseeb tias pib ua haujlwm ntawm CPK (≥ 5 VGN).

Cov neeg mob yuav tsum paub txog qhov xav tau tam sim ntawd qhia tus kws kho mob txog cov tsos mob ntawm cov tsos mob uas tsis tau sau tseg dhau los, cov leeg mob ntawm qhov tsis paub tseeb, tsis muaj zog thiab / lossis qaug dab peg, tshwj xeeb tshaj yog thaum ua ke nrog malaise thiab kub taub hau. Kev kho yog nres thaum CPK kev ua haujlwm yog 5 zaug siab dua ntawm VGN lossis nyob ntawm qhov mob ntawm cov leeg mob hnyav uas ua rau muaj qhov tsis xis nyob. Tom qab ploj ntawm cov tsos mob thiab kev ua haujlwm tsis tu ncua ntawm KFK kev ua haujlwm, cov lus nug ntawm kev siv rosuvastatin hauv qhov koob tshuaj tsawg kawg nkaus thiab nyob rau hauv kev saib xyuas zoo yuav tsum rov xav dua. Nws yog qhov tsis raug cai los ua qhov kev soj ntsuam txhua tus ua haujlwm ntawm CPK yam tsis muaj tsos mob.

Ua ntej pib kev kho mob thiab nyob rau 3 lub hlis ntawm kev kho, kev kuaj pom kev ua haujlwm ntawm daim siab yog pom zoo.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov kev tshawb fawb ntawm cov nyhuv ntawm rosuvastatin ntawm kev muaj peev xwm mloog zoo thiab qhov ceev ntawm psychomotor cov nyom tsis tau ua. Tab sis thaum ua tiav cov kev phom sij txaus ntshai, suav nrog kev tsav tsheb, nws yuav tsum tau yug los rau hauv lub siab tias kiv taub hau yog ua tau nrog Tevastor txoj kev kho.

Cev xeeb tub thiab lactation

Tevastor yog contraindicated rau kev kho mob ntawm cev xeeb tub thiab pub mis niam cov poj niam. Thiab yog tias kuaj kev kuaj mob thaum cev xeeb tub, cov tshuaj yuav tsum nres tam sim ntawd.

Cov poj niam ntawm kev ua me nyuam hnub nyoog yuav tsum tau siv txoj hauv kev tiv thaiv kom zoo. Cov roj cholesterol, nrog rau cov khoom lag luam ntawm nws cov biosynthesis, ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov menyuam hauv plab, yog li, qhov kev pheej hmoo ntawm kev tiv thaiv HMG-CoA reductase tseem ceeb tshaj qhov txiaj ntsig zoo ntawm kev siv Tevastor.

Cov kev tshawb fawb txog kev tawm ntawm rosuvastatin hauv kev pub mis niam tsis tau ua tiav, thiab yog li ntawd, yog tias nws yuav tsum siv Tevastor thaum lactation, kev pub mis rau menyuam yuav tsum tau nres.

Nrog lub raum tsis ua haujlwm

Cov neeg mob uas mob raum tsis mob pes tsawg tsis tas yuav tau txhaj tshuaj rosuvastatin. Hauv kev mob raum tsis zoo (CC

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Ntau tshaj $ 500 lab tau ib xyoo yog siv rau cov tshuaj tiv thaiv ua xua nkaus xwb nyob hauv Tebchaws Meskas. Koj puas tseem ntseeg tias txoj hauv kev uas thaum kawg kov yeej kev ua xua yuav pom?

Hauv tebchaws Askiv, muaj txoj cai lij choj raws li uas tus kws phais neeg tuaj yeem tsis kam ua haujlwm rau tus neeg mob yog tias nws haus luam yeeb lossis rog dhau. Ib tus neeg yuav tsum tso tawm tus cwj pwm tsis zoo, thiab tom qab ntawd, tej zaum, nws yuav tsis xav tau kev phais mob.

Raws li kev txheeb cais, nyob rau hnub Monday, kev pheej hmoo ntawm nraub qaum nce ntxiv li 25%, thiab kev pheej hmoo ntawm mob plawv - los ntawm 33%. Kom ceev faj.

Muaj 74 xyoo nyob hauv tebchaws Australian yawg James Harrison tau los ua neeg muab ntshav li 1,000 zaus. Nws muaj ib hom ntshav uas tsis tshua muaj, cov tshuaj tiv thaiv uas pab cov menyuam mos liab uas muaj ntshav tsawg txaus kom ciaj sia taus. Yog li, Australian thiaj cawm tau ntau txog ob lab tus menyuam.

Nws tau siv los ua yawning enriches lub cev nrog oxygen. Txawm li cas los xij, qhov kev pom no tau nthuav dav. Cov kws tshawb fawb tau ua pov thawj tias yawning, ib tus neeg ua kom lub hlwb txias thiab txhim kho kev ua haujlwm.

Ntxiv rau tib neeg, tsuas yog ib qho tsiaj muaj sia nyob hauv ntiaj chaw ntiaj teb - dev, raug kev txom nyem los ntawm prostatitis. Cov no yog peb cov phooj ywg ncaj ncees tshaj plaws.

Muaj ntau cov kev kho mob nthuav tawm heev, xws li kev siv khoom tsis nco qab ntawm cov khoom. Hauv plab ntawm ib tus neeg mob uas tau mob los ntawm tus txiv neej no, 2500 cov khoom txawv teb chaws tau pom.

Nrog kev mus saib xyuas lub txaj tanning, txoj kev pheej hmoo ntawm kev mob qog tawv nqaij yuav nce 60%.

Cov kws kho hniav tau tshwm sim tsis ntev los no. Rov qab rau hauv lub xyoo pua puv 19, nws yog lub luag haujlwm ntawm tus kws tu plaub hau kom rub tawm cov hniav mob.

Raws li kev tshawb fawb los ntawm WHO, kev sib tham ib nrab hnub nyob rau ntawm lub xov tooj ntawm tes tau qhov feem ntau ntawm kev txhim kho lub hlwb lub hlwb los ntawm 40%.

Txhawm rau hais txawm tias cov lus luv thiab yooj yim, peb siv 72 leeg leeg.

Cov poj niam feem ntau muaj peev xwm tau txais kev lom zem ntau dua los ntawm kev xav txog lawv lub cev zoo nkauj hauv daim iav dua li ntawm kev sib deev. Yog li, cov poj niam, siv zog ua kom muaj kev sib haum xeeb.

Thaum lub sijhawm ua haujlwm, peb lub hlwb siv ntau npaum li cas ntawm lub zog sib npaug rau 10-watt lub teeb lub teeb. Yog li cov duab ntawm lub teeb txawb saum koj lub taub hau thaum lub sijhawm pom ntawm qhov kev xav zoo nkauj tsis yog deb ntawm qhov tseeb.

Txhua tus neeg muaj tsis tsuas yog nyias tus ntiv tes, tab sis kuj hais lus.

Yog tias koj lub siab ua haujlwm, kev tuag yuav tshwm sim hauv ib hnub.

Cov roj ntses tau paub txog ntau xyoo lawm, thiab lub sijhawm no nws tau muaj pov thawj tias nws pab daws kev mob, txo kev mob sib koom tes, txhim kho sos.

Cov tshuaj ua haujlwm li cas?

Hauv lub cev ntawm txhua tus neeg muaj cov rog tshwj xeeb uas muaj peev xwm muaj kev cuam tshuam zoo tiag tiag rau hauv lub cev, txo nws qhov ntsuas kev noj qab haus huv.

Cov roj ua rog txhawm rau txhawm rau tawm ntawm cov phab ntsa ntawm cov hlab ntsha, cov ntawv me me, ua rau cov khoom noj muaj txiaj ntsig zoo rau txhua cov ntaub so ntswg, cov hlab ntsha thiab leeg ntshav, nrog rau. Tag nrho cov no ua rau ntau yam kabmob, ob leeg ntawm cov hlab ntsha lawv tus kheej thiab hauv lub siab.

Cov kws kho mob niaj hnub sau npe rau Tevastor kom cov tshuaj muaj qhov tshwj xeeb rau lub siab, qhov twg qhov tshwj xeeb ntawm kev ua kom tiav cov nqaijrog, uas yog, xws li cov tshuaj tseem ceeb xws li lipoproteins, yog nqa tawm.

Cov txiaj ntsig zoo xub thawj ntawm kev kho mob nrog cov tshuaj no tuaj yeem xav txog ib lis piam tom qab thawj zaug kev pib tshuaj. Qhov siab tshaj plaws yuav tuaj yeem tau txais thiab pom hauv ib lub hlis.

Los ua kev tswj xyuas kev ua haujlwm tau zoo, cov kev tshawb fawb txog ntshav muaj pes tsawg leeg yog ua tiav, uas qhia kev hloov pauv dav hauv cov theem siab hauv cov ntshav ntawm txhua hom lipoproteins.

Nyob rau tib lub sijhawm, cov tshuaj muab cov txiaj ntsig zoo nrog kev ua haujlwm tsis zoo ntawm tib neeg endothelium, txhim kho lub rheological zoo tag nrho ntawm cov ntshav muaj pes tsawg leeg, uas yog, ntshav fluidity.

Ib qho tseem ceeb ntxiv, cov tshuaj zoo dua yog cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob antioxidant. Nyob rau tib lub sijhawm, cov yeeb tshuaj hauv qab no muaj peev xwm sau tseg:

1. Tevastor, cov lus qhia rau kev siv uas yog nkag siab, zoo ib yam nkaus muaj feem xyuam rau lub cev, tsis hais poj niam txiv neej thiab hnub nyoog.
2. Nrog rau daim foos hnyav thiab hais txog daim siab ua kom tsis haum, cov tshuaj lom ntawm cov tshuaj tseem ceeb hauv cov ntshav yuav siab txog peb zaug dua li ib txwm.
3. Cov yam ntxwv ntawm pharmacokinetics nyob ntawm seb haiv neeg thiab qhov chaw nyob ntawm cov neeg mob. Cov Neeg Nyij Pooj thiab Suav tau nce ob npaug hauv qhov nruab nrab lub ntsiab, uas tsis tau pom ntawm cov neeg Europe.

Txawm li cas los xij, cov txheej txheem kho tshuaj yog pom muaj tus yam ntxwv ua tau zoo thiab qhov tsawg ntawm cov kev mob tshwm sim, tshwj rau cov neeg tsis kam txais.

Daim foos tso tawm thiab cov cai tswjfwm rau kev nkag mus kawm

Tevastor, cov lus qhia ntawm uas yuav tsum tau ua raws thaum lub sijhawm kho, yog cov tshuaj kho mob uas muaj nrog ntau qib ntawm cov tshuaj lom ntawm lub ntsiab feem, uas yog rosuvastine. Nws yuav tsum tau ua raws li cov lus pom zoo los ntawm tus kws kho mob thiab cov lus qhia ntawm cov tshuaj nws tus kheej.

Ntawm cov kev cai yooj yim rau kev noj cov tshuaj tuaj yeem paub qhov txawv:

• Cov tshuaj no tau noj tsis hais txog pluas mov noj li cas,
• Kev kho mob pib nrog qhov noj tsawg kawg, maj mam nce nws hauv kev ua tib zoo saib
• cov kws tshaj lij
• Yog tias tsim nyog, nqa tawm kev kho mob hauv kev siv tshuaj ntau dhau, tus neeg mob kuj tau txais kev saib xyuas tshaj plaws thiab kev saib xyuas txhua yam,
• Ua ntej pib kev kho mob, tus neeg mob raug nquahu kom yauv tsum noj cov lipid-txo cov zaub mov tshwj xeeb. Nws yuav xav kom yoog txhua lub sijhawm ntawm kev kho.

Lub cim tseem ceeb rau kev siv

Cov tshuaj yog tawm rau ntau yam teeb meem cuam tshuam nrog hypertriglyceridemia. Indispensable hauv kev kho mob ntawm cov roj cholesterol siab.

Cov tshuaj tuaj yeem siv los ua cov tshuaj ntxiv rau hauv cov zaub mov nrog yam tsawg kawg ntawm cov rog. Qhov ua tau zoo tuaj yeem ua tiav tuaj yeem kho tus mob atherosclerosis.

Tag nrho cov no yog cov kev kuaj mob tshaj plaws rau kev kho mob uas cov kws kho mob tau sau tseg Tevastor. Qhov zoo ntawm cov tshuaj no yog qhov ua tau ntawm nws txoj kev siv ua kev tiv thaiv kab mob ntawm cov kab mob hauv lub plawv thiab cov hlab ntsha.

Piv txwv li, cov tshuaj hauv nws qhov tsawg kawg nkaus tuaj yeem siv tau los ntawm txhua tus txiv neej los ntawm 55 xyoo thiab cov poj niam txij 60 xyoo. Cov prophylactic siv cov tshuaj yog qhia rau txhua tus neeg haus luam yeeb thiab cov uas muaj lwm yam teeb meem kev noj qab haus huv zoo sib xws.

Hais txog ib yam tshuaj xws li Tevastor, kev tshuaj xyuas tus neeg mob tuaj yeem pom muaj zoo li qhov ua tau.

Analogues ntawm cov tshuaj

Tevastor analogues, zoo li lwm yam tshuaj. Nws yog tsim los ntawm txawv tuam ntxhab, uas yog vim li cas nws lub npe, ntau npaum li cas, thiab muaj cov khoom ntxiv yuav txawv.

Cov tshuaj Analogues ntawm cov tshuaj muaj xws li ib pawg ntawm cov tshuaj, qhov twg cov khoom tseem ceeb ua ke yog rosuvastine.

Kev npaj ntawm pawg no yog tus cwj pwm ntawm tib lub ntsuas rau siv, contraindications, thiab tseem tuaj yeem ua rau tib cov kev mob tshwm sim. Xws li cov cuab yeej, Tevastor, kev sib piv ntawm cov hloov pauv yuav muaj cov hauv qab no:

Kev siv tshuaj, zoo ib yam li cov tshuaj nws tus kheej, yuav tsum yog kws kho tshwj xeeb los ntawm cov kws kho mob ua paub txog kev kho mob. Nws yuav coj mus rau hauv tus yam ntxwv ntawm chav kawm ntawm tus kab mob, nws tus kheej tsis kam, nrog rau cov khoom kom zoo rau tus neeg mob, txij li thaum tus nqi ntawm cov tshuaj nyob ntawm tus neeg tsim khoom.

Tus nqi rau Tevastor muaj nqis, cov tshuaj tau muag nruab nrab ntawm tus nqi 220 rubles rau ib ntsiav tshuaj nrog qhov tshuaj ntawm 5 mg, thiab rau Tevastor 20 mg tus nqi tau teeb tsa ntawm kwv yees li 800 rubles.

Tevastor Xyuas

Txog ib cov tshuaj xws li Tevastor, kev txheeb xyuas hauv lub network tsuas yog pom qhov zoo. Cov neeg mob tau txo qis hauv cov roj hauv cov ntshav siab ntau, txhim kho kev noj qab haus huv txhua yam.

Txog yeeb tshuaj Tevastor tshuaj xyuas ntawm kws kho mob kuj pom tias zoo. Nov yog qee qhov ntawm kev ua piv txwv.

Phiv thiab tshaj ntawm Tevastor

Peb yuav sau tsuas yog cov kev ua txhaum uas tau ntsib hauv kev coj ua los siv cov statin no ntau zaus (tsawg kawg hauv ib kis tawm ntawm ib puas) thiab ntau zaus (hauv ib kis tawm ntawm kaum).

Yog li, cov neeg mob feem ntau txhim kho cov kab mob endocrine system, nrog rau mob ntshav qab zib mellitus. Kuj, mob taub hau, mob plab zom mov feem ntau pom. Los ntawm cov leeg ua haujlwm, nqaij leeg mob, mob leeg nqaij, mob hlwb tuaj yeem tsim kho.

Kwv yees li peb ntawm ib puas tus neeg mob siv koob ntawm plaub caug milligrams muaj protein nyob hauv lawv cov zis.

Kev overdose ntawm Tevastor yog fraught nrog cov tsos ntawm kev phiv. Txoj kev kho yog kho nyob ntawm tus tsos mob.

Cov poj niam uas tau txhaj tshuaj Tevastor yuav tsum ua tib zoo tiv thaiv lawv tus kheej los ntawm kev xeeb tub. Ua ntej pib txoj kev kho, koj yuav tsum ua qhov kev ntsuas cev xeeb tub. Yog tias kev xeeb tub tseem tshwm sim, koj yuav tsum siv tam sim no tso tseg thiab siv tus kws kho mob sai li sai tau.

Tevastor ntsiav tshuaj: cov lus qhia rau kev siv, analogues, tus nqi thiab tshuaj xyuas

Tevastor yog yeeb tshuaj uas zwm rau pab pawg statins. Lub ntsiab ua haujlwm tseem ceeb ntawm cov tshuaj yog rosuvastatin calcium.

Cov tshuaj txo cov ntshav ntxiv rau hauv ib yam khoom xws li qis lipoprotein tsawg. Tib lub sijhawm, hauv kev ua los ntawm kev noj tag nrho cov roj hauv cov ntshav yuav tsum txo qis.

Cov tshuaj Tevastor: cov lus qhia rau kev siv

Tevastor yog ib feem ntawm pawg ntawm lipid-txo cov tshuaj.

Thaum lub neej, cov nqaij rog muaj teeb meem ntau ntxiv hauv cov nkoj thiab cov quav hniav. Qhov no ua rau cov ntshav tsis txaus, atherosclerosis, oxygen oxygen tshaib plab ntawm cov khoom nruab nrog cev, mob plawv nres.

Hypercholesterolemia (txhawb cov roj ntshav hauv ntshav siab) yog qhov ua ntej rau kev mob plawv thiab leeg tshav. Txhawm rau txhawm rau tiv thaiv qhov ua rau muaj kev phom sij, nws yog qhov tsim nyog los txo cov qib phom sij uas muaj kev phom sij.

Kev siv Tevastor muaj txiaj ntsig zoo rau cov rog rog, yog kev tiv thaiv cov kab mob plawv.

Tevastor yog ib feem ntawm pawg ntawm lipid-txo cov tshuaj.

Pharmacological kev txiav txim

Lub siab yog lub luag haujlwm rau kev tawg ntawm cov rog, nrog rau cov lipoproteins (LP). Kev siv tshuaj hypolipidemic ua rau cov neeg mob ntshav qab zib qis lipoprotein receptors (LDL) nce ntxiv, nce lawv cov catabolism thiab kev kho mob. Cov synthesis ntawm txawm qis ntom lipoproteins (VLDL) qis qis. Qhov no ua rau muaj kev txo qis hauv kev saib xyuas ntawm cov cholesterol hauv cov ntshav.

Tus neeg muag tshuaj muaj cov tshuaj xaiv tau zoo. Nws txoj kev sib tw inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). Vim qhov no, qhov piv tau txo:

• tag nrho cov roj (cholesterol) thiab cov roj (cholesterol) cuam tshuam nrog qhov siab ntawm lipoproteins (HDL),
• non-HDL roj thiab roj cholesterol HDL
• LDL ntsig txog roj (cholesterol) thiab cov roj cholesterol HDL-ntsig txog,
• apolipoprotein A-1 thiab apolipoprotein B.

Cov tshuaj tuaj yeem raug kho rau veins veins.

Kev siv Tevastor muaj cov txiaj ntsig zoo tsis yog rau lub xeev ntawm cov hlab ntsha nkaus xwb, tab sis kuj rau ntawm leeg. Cov tshuaj tuaj yeem raug kho rau veins veins. Nws txhim kho cov ntshav ncig, pab muab cov pa oxygen rau cov nqaij thiab cov plab hnyuv siab raum, ntxuav thiab ua kom lub zog ntawm cov hlab ntshav thiab cov leeg ntshav.

Yuav Ua Li Cas Tevastor

Ua ntej noj cov tshuaj thiab thoob plaws hauv lub chav kho mob, koj yuav tsum ua raws li cov zaub mov lipid-txo cov zaub mov.

Qhov no yuav ua rau kom muaj txiaj ntsig ntawm cov tshuaj nquag thiab tshem tawm cov hnyav ntxiv rau daim siab.

Cov ntau npaum yog xaiv los ntawm tus kws kho mob ib leeg zuj zus. Lub xub ntiag ntawm cov kab mob ntev thiab qhov mob ntawm lub cev tau coj los txiav txim siab. Tus neeg mob tus txiv neej tsis muaj teeb meem.

Thawj koob tshuaj yog 5 mg. Cov ntsiav tshuaj noj ntawm qhov ncauj, ntxuav nrog dej. Lub sijhawm ntawm nruab hnub thiab khoom noj kom tsawg. Qhov kawg kho yam tsawg kawg yog 7 hnub. Txhawm rau kom ua tiav cov txiaj ntsig, cov tshuaj raug rau ib hlis lossis ntau dua.

Yog tias qhov kev ntsuas pom kev ntsuam xyuas tom qab 4 lub lis piam qhia pom qhov tsis zoo, qhov ntau npaum li cas yuav nce ntxiv rau 10 lossis 20 mg ib hnub. 40 mg ntsiav tshuaj tau xaj tsuas yog qee qhov xwm txheej, vim lawv feem ntau ua rau muaj kev phiv. Hauv qhov no, tus neeg mob yuav tsum nyob hauv kev saib xyuas ntawm tus kws kho mob.

Ua ntej noj cov tshuaj thiab thoob plaws hauv lub chav kho mob, koj yuav tsum ua raws li cov zaub mov lipid-txo cov zaub mov.

Cov neeg mob mentsis lossis mob raum tsis zoo raug tso cai muab Tevastor rau ib koob tshuaj. Hauv cov teeb meem loj, kev kho nrog tus neeg sawv cev kws tshuaj no tau pom zoo kom muab pov tseg.

Tus kws kho mob suav tias yuav muaj txiaj ntsig zoo thiab tsis phom sij rau tus neeg mob txoj kev noj qab haus huv, thiab tom qab ntawv muab tshuaj kho.

Lub siab ua haujlwm tsis zoo yog lub laj thawj rau kev saib xyuas tus neeg mob thaum noj Tevastor. Kab mob siab tsis txaus ua rau qaug dab peg nrog rosuvastatin, uas ntev mus ua ke nrog cov ntshav thoob plaws lub cev. Qhov no tuaj yeem cuam tshuam ntau yam kev mob ntawm ob lub raum thiab ua rau lawv poob.

Siv thaum cev xeeb tub thiab lactation

Cov roj (cholesterol) yog qhov tseem ceeb rau txoj kev loj hlob ntawm tus menyuam hauv niam lub plab. Tus neeg saib xyuas lipid-txo qis ua rau muaj kev cuam tshuam ntawm kev tsim ntawm tus me nyuam thiab kev loj hlob ntawm tus menyuam. Yog li no, thaum lub sijhawm menyuam xeeb menyuam thiab pub mis niam mis, noj Tevastor yog txwv tsis pub.

Cov roj (cholesterol) yog qhov tseem ceeb rau txoj kev loj hlob ntawm tus menyuam hauv niam lub plab.

Yeeb tshuaj sib cuam tshuam

Txais Tos ntawm Tevastor yog txwv ib txhij nrog:

1. Cyclosporine. Nrog kev sib cuam tshuam ntawm cov tshuaj no, cov ntsiab lus ntawm rosuvastatin nce 10 zaug. Qhov no tuaj yeem cuam tshuam txog lub siab ua haujlwm.
2. Gemfibrozil. Yog tias cov tshuaj no noj ib txhij nrog Tevastor, cov tshuaj ntawm cov tshuaj nquag yuav nce ntxiv 2 zaug.
3. Qhov tshuaj tiv thaiv Vitamin K. Qhov no ua ke ntawm cov tshuaj cuam tshuam rau cov ntshav coagulation. Thaum noj, lub sijhawm coagulation nce, thaum tso tseg, nws nce.
4. Qhov ncauj txwv tsis pub muaj. Cov tshuaj nquag ua rau cuam tshuam txog theem ntawm cov tshuaj hormones.
5. Antiviral tshuaj uas inhibit protease. Txwv tsis pub, qib ntawm rosuvastatin nce 5 zaug.
6. Antacid kho cov neeg sawv cev. Aluminium thiab magnesium uas muaj nyob hauv lawv txo qhov kev mloog zoo ntawm cov khoom ua kom nquag plias los ntawm 2 zaug.

Ua ntej pib kev kho mob nrog ib tus neeg tso kua roj lipid, nws yog qhov yuav tsum tau qhia rau tus kws kho mob txog cov tshuaj uas tau noj ntxiv. Cov ntaub ntawv no yuav pab koj xaiv cov tshuaj kom haum thiab zam kev phiv tshuaj.

Daim ntawv tso tawm thiab tshuaj noj

Tevastor - ntsiav tshuaj tsim nrog ntau qhov sib txawv ntawm cov tshuaj nquag - rosuvastatin. Coj lawv raws li cov lus qhia, thaum nws yooj yim rau tus neeg mob, tsis hais noj mov dab tsi.

Lawv pib kho nrog kev noj tsawg kawg, saib xyuas tus neeg mob tus mob thawj lub hlis. Yog tias tsim nyog, nce qhov ntau ntawm cov tshuaj. Thaum muab tshuaj ntau dua, qhov kev saib xyuas thiab kev saib xyuas zoo yog ua tiav rau tus neeg mob.

Ua ntej pib kho nrog Tevastor, tus neeg mob yuav tsum ua raws li niaj zaus lipid-txo cov zaub mov noj thiab nyob rau nws rau tag nrho lub sijhawm kho nrog cov tshuaj qhia.

Cov koob tshuaj ntawm cov tshuaj tau xaiv ib tus zuj zus thiab nws nyob ntawm qhov ntsuas.

Phiv thiab haus tshaj

Cov kev mob tshwm sim uas yuav tshwm sim thaum noj Tevastor feem ntau yog mob sib khuav xwb thiab feem ntau yuav ploj lawv tus kheej. Qhov ntau thiab tsawg ntawm cov kev mob tshwm sim yog qhov thiaj li hu ua koob tshuaj.

Peb sau cov kev ua txhaum cai uas tuaj yeem tshwm sim thaum siv rosuvastatin feem ntau (ib kis tawm ntawm ib puas) thiab ntau zaus (ib kis tawm ntawm kaum):

• muaj kev ntxhov siab nyob rau hauv kev ua haujlwm ntawm cov tshuaj endocrine raug sau tseg, feem ntau nws yog ntshav qab zib mellitus,
• mob taub hau ntev, kiv taub hau,
• kev mob plab zom mov (xeev siab, cem quav, mob epigastric, mob ntuav),
• angioedema,
• proteinuria (mob ntshav hauv lub raum),
• ntawm ntu ntawm cov leeg txheej txheem mob hlwb muaj qhov pheej hmoo ntawm myositis, asthenia, mob leeg nqaij,
• thaum siv koob tshuaj ntawm plaub caug milligrams nyob rau hauv cov zis, cov ntsiab lus protein raug pom.

Cov kev tshawb fawb hauv chav kuaj mob tau pom tias muaj qhov nce ntxiv ntawm cov bilirubin thiab qabzib, cov haujlwm ntawm GGT,

Kev noj tshuaj ntau dhau ntawm Tevastor yog fraught nrog kev ua kom pom kev mob tshwm sim, kev kho mob uas tau kho raws li cov tsos mob.

Saib xyuas! Cov poj niam noj Tevastor yuav tsum ua tib zoo tiv thaiv lawv tus kheej los ntawm cev xeeb tub, thiab thaum cev xeeb tub, tsum tsis txhob noj tshuaj tam sim ntawd thiab nrhiav kev kho mob sai sai.

Tevastor: cov lus qhia rau kev siv, tshuaj xyuas thiab analogues

Coob tus ntawm cov neeg ntawm lub hnub nyoog laus tau ntsib nrog cov teeb meem hauv metabolic, uas yog vim txoj kev ua neej ntawm ib tus neeg niaj hnub. Kev txwv ntawm kev ua haujlwm ntawm lub cev, kev tsim txom cov cawv thiab dej cawv, noj transgenic, cov zaub mov tsis tshua muaj zaub mov zoo ua rau muaj kev hloov hauv lipid profile thiab yav tom ntej rau kev txhim kho atherosclerosis.

Los ua kom cov metabolism hauv cov rog hauv lub cev, ntxiv rau txoj kev ua kom lub cev muaj zog thiab kev noj zaub mov zoo, siv tshuaj kho. Raws li cov lus qhia rau kev siv nrog tshuaj Tevastor, nws yog ib qho cuab yeej uas txo qis cov rog. Raws li cov kws tshaj lij thiab cov neeg mob, tus nqi ntawm cov tshuaj no yog ua tau zoo nrog zoo thiab tsis yog qis dua ntawm analogues.

Cov ntaub ntawv xov xwm dav dav txog Tevastor

Ntau cov kev tshawb fawb soj ntsuam tau ua pov thawj lub peev xwm ntawm statins los txo cov kev pheej hmoo ntawm kev tsim kab mob plawv. Raws li cov lus pom zoo thoob ntiaj teb (Cov koom haum European thiab Asmeskas cov kws kho plawv), tsis yog qhia rau cov neeg muaj mob atherosclerosis thiab lipid qhov teeb meem nkaus xwb, tab sis kuj muaj qee yam ntawm cov neeg uas muaj cov roj (cholesterol) sib luag.

Nws raug nquahu kom noj cov tshuaj statins yog tias muaj keeb kwm ntawm lub plawv nres, mob hlab ntsha tawg, mob ntshav nce hlwb, mob ntshav qab zib mellitus ntau ntxiv nrog kev mob ntshav siab, thiab lub raum tsis ua haujlwm loj. Pab pawg no cov tshuaj suav nrog Tevastor.

Cov pab pawg tshuaj, INN, thaj tsam

Ua raws li Anatomical thiab kho kev faib tawm cov tshuaj, Tevastor yog ib qho tshuaj monocomponent lipid-txo tshuaj. Cov tshuaj muaj zog sib raug mus rau thoob ntiaj teb nonproprietary npe - rosuvastatin. Nws yog tus sawv cev ntawm cov inhibitors ntawm qhov enzyme HMG-CoA reductase nrog kev xaiv ntawm kev ua thiab yog rau cov pab pawg ntawm statins ntawm 4 tiam.

Nws yog dav siv los ntawm cov kws kho plawv kom txo txoj kev pheej hmoo ntawm kev txhim kho cov hlab plawv hauv cov neeg muaj kev pheej hmoo siab ntawm SCORE nplai, ntxiv rau kev kho cov mob atherosclerosis.

Cov qauv kev tso tawm thiab tshuaj yeeb tshuaj, nruab nrab hauv Lavxias

Tus nqi ntawm cov tshuaj Tevastor ncaj qha nyob ntawm qhov ntau npaum. Kuj tseem qhia me ntsis hloov pauv nyob ntawm seb lub zos. Ntawm kev muag khoom yog pob ntawm 30 thiab 90 daim. Tus nqi hauv lub rooj yog rau ib pob ntawm peb lub hlwv ntawm kaum ntsiav tshuaj.

Rosuvastatin calcium muaj cov nyhuv ua haujlwm. Nws hais txog kev xaiv cov blockers ntawm cov enzyme uas tswj cov synthesis ntawm cov roj cholesterol - HMG-Coa-Reductase.

Cov neeg tsim khoom siv cov lactose, microcrystalline cellulose, talc ua cov muab tub lim. Txhawm rau ntxiv xim, dyes tau muaj nyob hauv qhov kev npaj - cov hlau oxides daj thiab liab, azorubine. Lawv muaj kev nyab xeeb rau kev noj qab haus huv thiab raug pom zoo rau siv hauv kev tsim tshuaj.

Cov Cai Siv Tshuaj So

Yog koj muaj ntawv yuav los ntawm kws kho mob.

Tus nqi yog nyob ntawm ntau tus naj npawb ntawm cov ntsiav tshuaj hauv pob thiab cov ntsiab lus ntawm cov tshuaj nquag nyob hauv lawv.

Tus nqi nruab nrab ntawm 5 mg ntsiav tshuaj yog 400 rubles.Ib cov tshuaj uas muaj 10 mg ntawm rosuvastatin nqi 470-500 rubles. Ntsiav tshuaj 20 mg - 600-700 rubles.

Yog tias koj tsis tuaj yeem nrhiav qhov tsim nyog lipid-txo qis tshuaj rau muag, koj tuaj yeem mloog nws cov duab.

Qhov muaj pes tsawg leeg thiab kev xaib ntawm Tevastor yog nyob ze rau cov tshuaj xws li:

• Atorvastatin
• Rosucard
• Mertenil
• Kwv Txhiaj Ntsuag
• Akorta,
• Xeb
• Neeg Coob
• Suvardio
• Rosulip,
• Rosicore
• Ro statin
• Razuvastatin,
• Hlua.

Ua ntej hloov cov tshuaj, nws raug nquahu kom sab laj nrog koj tus kws kho mob. Tus kws kho mob yuav coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob thiab xaiv cov tshuaj zoo tshaj plaws.

Cov cai rau kev tswj hwm kev nyab xeeb thiab noj ntau npaum li cas

Lub sijhawm kev kho mob yuav tsum tau muaj kev noj zaub mov kom zoo rau cov tsiaj rog thiab cov zom zaub kom yooj yim. Tsis tas li, cuam tshuam nrog lwm cov tshuaj yuav tsum tau txiav txim siab. Ntawm kev ceeb toom tshwj xeeb yog kev sib xyaw ntawm rosuvastatin nrog cyclosporins, vitamin K kev thaiv kev tsis sib haum, sib xyaw ua ke qhov ncauj, erythromycin.

Feem ntau, cov tshuaj pib yog 5 mg (1/2 ntsiav tshuaj muaj 10 mg ntawm rosuvastatin). Cov ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj txhua lub sijhawm ntawm lub hnub. Noj yuav tsis muaj qhov cuam tshuam tseem ceeb ntawm cov tshuaj pharmacokinetics thiab cov chaw muag tshuaj. Nws tsis pom zoo los zom thiab zom cov tshuaj.

Tseem Ceeb! Tom qab 4 lub lim tiam ntawm kev nquag ua haujlwm, daim lipid yuav tsum tau rov ua dua thiab, yog tias tsim nyog, yuav tsum tau kho qhov ntau npaum li cas.

Muaj cov tshuaj tsis haum thiab noj tshaj

Feem ntau, kev kho mob nrog Tevastor tsis muaj kev cuam tshuam zoo rau kev muaj txiaj ntsig zoo thiab muaj peev xwm zam tau yooj yim. Txawm li cas los xij, nrog kev tsis txaus siab rau ib qho ntawm ib qho, kev siv tshuaj tsis raug, thiab tsis ua raws li cov lus pom zoo rau kev noj tshuaj, cov kev mob tshwm sim hauv qab no yuav tshwm sim:

• mob rau daim siab mob siab, nrog rau mob daj ntseg thiab nce siab kev kuaj ntshav siab (thymol, AST, ALT, tag nrho bilirubin), Kab mob siab mob siab
• tso quav (ua kom raws plab, raws plab),
• kev ua xua, nrog rau ntawm daim tawv nqaij liab, khaus, Quincke's edema,
• qee zaus, hnoos qhuav, ua pa luv,
• kiv taub hau, tsaus muag,
• ua txhaum kev puas siab ntsws ntawm kev puas siab ntsws (kev npau taws, npau taws).

Yog tias cov tsos mob saum toj no tshwm sim, koj yuav tsum tsis txhob noj tshuaj thiab sab laj nrog kws kho mob los saib xyuas lub raum thiab lub siab ua haujlwm.

Txheeb xyuas cov txiaj ntsig ntawm Tevastor

Ntau cov kev tshuaj xyuas los ntawm cov neeg mob thiab cov kws kho mob pab soj ntsuam Tevastor.

Marina, 48 xyoo: “Los ntawm lub sijhawm, thaum tshuaj xyuas hauv chaw kho mob, lawv pom muaj roj cholesterol siab. Kuv rau zaub mov noj tau ob lub hlis, tsis muaj tshwm sim. Tus kws kho plawv tawm tswv yim Tevastor hauv ib nrab 10 ntsiav tshuaj. Pom txhua hnub thaum sawv ntxov. Ib hlis tom qab, cov roj (cholesterol) poob yuav luag ib txwm nyob. ”

Victor, 65 xyoo: “Ob xyoos dhau los nws tau mob plawv, thiab pib ntsuam xyuas kom ntxaws. Tus kws kho mob tau sau tshuaj kom txo cov roj (cholesterol) ua ib qho kev tiv thaiv rov ua dua. Kuv hnov ​​zoo, tab sis thawj lub hlis tom qab noj cov tshuaj Kuv zoo li xeev siab.

Kuv tseem yuav noj cov tshuaj no, lawv cov nqi pheej yig, thiab qhov zoo yog qhov siab heev, xeev siab dhau lawm. "Alexander, 43 xyoo:" Hauv peb tsev neeg, tom qab 40 xyoo, txhua tus muaj teeb meem ntshav siab thiab roj. Kuv tsis muaj kev zam hlo li. Tevastor tau sau tseg, tab sis cov tshuaj tsis haum rau kuv.

Sai li tom qab noj lub kiv taub hau, Kuv xav pw. Tus kws kho mob tau hais tias ua siab ntev - nws feem ntau tshwm sim, tab sis kuv xav tias nws zoo dua los hloov nws yog tias cov tshuaj tsis haum rau tam sim ntawd. "

Golub Olga Vasilievna, kws kho mob kev paub, 18 xyoo ntawm kev paub: “Tevastor tau siv los kho cov lipid metabolism hauv cov neeg laus dua 50 xyoo nrog kev mob ntshav siab. Feem ntau kho tau zoo txaus, cov tshuaj muaj nyob hauv cov tsev muag tshuaj feem ntau, tus nqi pheej yig.

Cov nyhuv tsis pom tam sim ntawd, tab sis mob siab rau lub sijhawm ntev. Txawm li cas los xij, kom tau txais kev kho mob kom ua tiav, nws yog ib qho tseem ceeb uas yuav tsum xaiv txoj cai tshuaj noj kom raug rau cov txiaj ntsig thiab txaus ntshai. "

Lub sijhawm pib tshuaj kho mob muaj qhov pom tseeb tshaj plaws nyob rau hauv kev sib xyaw nrog txoj kev ua neej nyob zoo. Statins tsis yog ib qho tshuaj yuav tsum tau ua hauv kev kuaj pom ntawm hypercholesterolemia, txawm li cas los xij, lawv lub hom phiaj tsuas yog txiav txim siab txhawm rau txhawm rau muaj kev pheej hmoo loj ntawm kev mob plawv.

Nws yuav tsum raug sau tseg tias Tevastor yog cov tshuaj noj tshuaj, nws txoj kev siv yuav tsum tau nrog kev saib xyuas lub siab thiab lub raum, nrog rau kev soj ntsuam ntshav siab.

Chaw thau khoom ... Cov Kws Muaj Txuj Ci (Obstetrics thiab Gynecology)

• 2009 - 2014, Donetsk National Medical University. M. Gorky
• 2014 - 2017, Zaporizhzhya State Medical University (ZDMU)
• 2017 - tam sim no, Kuv tab tom ua haujlwm rau hauv kev kho mob hauv tsev menyuam thiab kev kho mob poj niam

Saib xyuas! Txhua cov ntaub ntawv ntawm lub vev xaib yog tshaj tawm rau lub hom phiaj ntawm kev paub. Tsis txhob muab tshuaj rau tus kheej. Nyob rau ntawm thawj cov cim qhia ntawm tus kab mob - sab laj tus kws kho mob rau tswv yim. Tseem muaj lus nug tom qab nyeem cov ntawv no? Lossis koj pom qhov yuam kev hauv tsab xov xwm, sau rau tus kws tshaj lij hauv txoj haujlwm.

Tevastor: cov lus qhia rau siv, analogues, cov nqi thiab tshuaj xyuas

Dab tsi yog Tevastor ntsiav tshuaj, cov lus qhia luv luv rau kev siv, cov analogues uas twb muaj lawm, tus nqi nruab nrab, nrog rau kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob - cov ntaub ntawv muaj txiaj ntsig uas tuaj yeem tau sau los ntawm tsab xov xwm no.

Muaj pes tsawg leeg thiab noj ntau npaum

Cov tshuaj Tevastor belongs rau cov kws kho mob pab pawg ntawm cov tshuaj tiv thaiv kev mob siab ntawm HMG-CoA reductase. Qhov enzyme no tau koom nrog hauv kev tsim cov cholesterol hauv hepatocytes. Cov statin no ua kom muaj ntau dua cov lipoproteins uas ntau los ntawm daim siab mob hlwb.

Nyob rau tib lub sijhawm, tus nqi ntawm cov roj (cholesterol) phem yuav tsawg dua.

Cov khoom xyaw tseem ceeb ntawm Tevastor, rosuvastatin, kho cov qib ntawm cov roj (cholesterol) tag nrho, ua kom cov triglycerides tsis meej, thiab ib txhij txo cov tshuaj apolipoproteins B hauv cov ntshav ncig.

Tevastor muaj nyob rau hauv daim ntawv ntawm cov kab hauv cov xim daj hauv lub plhaub. Rosuvastatin tuaj yeem muas tau ntawm koob tshuaj 5, 10, 20 thiab 40 mg. Cov txheej txheem pob muaj 30 lossis 90 ntsiav tshuaj, kaw hauv hlwv ntawm 10 daim. Lub teb chaws ntawm keeb kwm - Ixayees.

Cov txiaj ntsig zoo ntawm kev kho nrog Tevastor feem ntau pom tom qab 7-10 hnub ntawm kev siv tas li. Qhov siab tshaj plaws ntawm kev ua haujlwm siab nyob hauv siab tshaj tshwm sim tom qab plaub lub lis piam ntawm kev muab tshuaj. Kev hloov kho ntawm thawj koob tshuaj yuav tsum tau nqa tawm ntawm lub hauv paus ntawm lipid cov xwm txheej cov ntaub ntawv thiab tsis ntxov dua tom qab ib hlis ntawm kev noj cov ntsiav tshuaj.

Tsuas tshuaj thiab tswj hwm

Tevastor tuaj yeem coj lub sijhawm twg los tau yooj yim rau koj. Tsis txhob zom cov ntsiav tshuaj; haus tag nrho nws nrog dej los yog tshuaj yej sov.

Kev tswj hwm ntawm kev npaj tshuaj yuav tsum tau ua ke nrog kev noj zaub mov kom zoo thiab ua kom lub cev. Tsuas yog tus kws kho mob tshwj xeeb muaj peev xwm xaiv qhov zoo tshaj plaws ntawm cov tshuaj, suav txog tus cwj pwm ntawm koj lub cev thiab keeb kwm kev kho mob.

Feem ntau, kev kho mob pib nrog pib txij li 5-10 mg. Yog tias tom qab ib hlis cov kev kho tsis tau ua tiav, kws kho mob kho qhov tshuaj ntawm cov tshuaj.

Saib xyuas kev ua tiav ntawm kev hloov kho kev kho mob yog nqa tawm siv lub chaw kuaj ntshav kuaj cov roj cholesterol thiab triglycerides.

Qhov siab tshaj plaws ntawm 40 mg yog qhia rau cov neeg mob hnyav hypercholesterolemia thiab concomitant mob plawv. Cov neeg mob zoo li no yog saib xyuas tas mus li.

Thaum cev xeeb tub thiab lactation

Cov poj niam nqa me nyuam, nws yog qhov tsis txaus siab siv cov tshuaj lipid-txo qis. Thaum cev xeeb tub, koj yuav tsum mus so.

Kev siv cov pab pawg ntawm cov tshuaj no raug tso cai tsuas yog tshwj xeeb thiab tsuas yog nyob hauv kev saib xyuas kev mob nkeeg nruj heev.

Yog tias muaj mob hnyav yuav tsum tau siv statins thaum pub niam mis, nws yuav tsum hloov tus menyuam mus rau qhov khoom noj khoom haus cuav.

Txij li thaum cov nyhuv ntawm cov tshuaj rau cov menyuam yaus lub cev tsis tau ua tib zoo kawm, cov tshuaj no tsis siv rau hauv kev kho menyuam yaus.

Kev Siv Tshuaj Xyuas

Cov kev xav ntawm cov kws kho mob thiab cov neeg mob nyob rau hauv kev sib koom tes - muaj tseeb muaj cov txiaj ntsig zoo los ntawm chav kawm ntawm rosuvastatin. Cov kws kho mob nco txog kev txhim kho hauv cov qib roj (cholesterol) nyob hauv ib lis piam thiab ib nrab los ntawm kev pib kho. Nyob rau tib lub sijhawm, nws yog qhov muaj peev xwm los kho qhov ntau npaum yog tsim nyog. Rosuvastatin haum zoo rau lub tswvyim ntawm kev kho mob hyperlipidemia classic.

Cov neeg mob nco tau yooj yim ntawm kev noj ib zaug ib hnub thiab yam tsis muaj kev cuam tshuam txog kev noj zaub mov. Cov kev mob tshwm sim feem ntau me thiab mob ib ntus. Qee tus yws txog tus nqi, tshwj xeeb tshaj yog thaum yuav ntau npaum li cas. Tab sis cov pej xeem feem coob uas tau siv cov tshuaj no txaus siab rau qhov tshwm sim ntawm kev kho mob thiab kev tiv thaiv cov rog hauv siab.

Kev Ntsuam Xyuas Rau Neeg Mob

Lyudmila, 53 xyoo, Moscow

Lub siab pib tsis sib thab nrog 47 xyoos. Kev mob siab thiab siab poob qis cuam tshuam nrog lub neej thiab haujlwm. Nthuav mus rau tus kws kho plawv, kuaj tau mob plawv nres. Tus kws kho mob tau hais tias coj Tevastor 10 mg ntsiav tshuaj rau ib hlis. Rov tshawb fawb dua qhia tau qhov txiaj ntsig zoo. Txoj kev pheej hmoo ntawm lub plawv nres poob qis, lub siab rov qab mus rau qhov qub. Kuv tsis pom tias muaj kev mob tshwm sim.

Elena, 59 xyoo, Vladivostok

Kuv tau mob plawv 3 xyoos dhau los, muaj kev phais plawv ntswj. Txhawm rau tiv thaiv qhov teeb meem no los ntawm kev tshwm sim dua, tus kws kho mob tau hais kom Tevastor. Cov tshuaj pab, tab sis kim heev. Muaj cov analogues pheej yig dua.

Victor, 64 xyoo, Rostov-on-Don

Kuv tau haus luam yeeb txij thaum kuv 21 xyoo. Kuv nyiam cov zaub mov muaj roj thiab kib. Vim tias qhov no, teeb meem nrog cov hlab ntsha tau pib. Cov ntshav ntsuam tau pom tias nce cov cholesterol ntau dua. Tus kws kho mob qhia Tevastor ntsiav tshuaj ua kev tiv thaiv ntawm atherosclerosis thiab mob plawv. Kuv noj cov tshuaj hauv 1 lub hlis kawm. Kuv pom kev txhim kho: kuv lub taub hau los ua kiv taub hau, tsis tshua hnov ​​qhov nrawm dua.

Thaum lub caij noj Tevastor, cov protein ntau hauv cov zis yuav nce ntxiv.

Cov kws kho mob tshuaj xyuas

Svetlana, kws kho plawv, hnub nyoog 44 xyoo, Astrakhan

Kom cov roj (cholesterol) nyob hauv ob tus laus thiab tus hluas. Txhawm rau tiv thaiv kev tsim cov plaques thiab cov pathologies txaus ntshai, Kuv sau tshuaj lipid-txo cov tshuaj. Kev kho mob nrog Tevastor muab tau txiaj ntsig zoo nyob rau hauv ib hlis. Cov roj khov ua rov qab zoo li qub. Txawm li cas los xij, txhawm rau kom tsis txhob rov ua dua, chav kawm ntawm kev tswj hwm yuav tsum tau ua ntu zus.

Anatoly, kws kho plawv, hnub nyoog 39 xyoo, Orenburg

Cov cwj pwm tsis zoo, tsis noj zaub mov tsis txaus, tsis muaj kev qoj ib ce ua rau muaj cov rog rog sai ua rau ntawm cov hlab ntsha. Nws yog ib qho tseem ceeb rau kev kuaj mob lawv lub sijhawm. Txhawm rau kho cov teeb meem no, Kuv xav kom Tevastor ntsiav tshuaj rau cov neeg mob. Lawv txo qis roj, tab sis rov tuaj yeem tshwm sim thaum lawv tso tseg. Yog li, nws yog ib qho tseem ceeb kom ua raws li kev noj zaub mov noj.

Tevastor ntsiav tshuaj: cov lus qhia rau kev siv thiab tshuaj ntawm kws kho mob

Raws li kev txheeb cais ntawm kev noj tshuaj nyob thoob plaws ntiaj teb, thawj qhov chaw nrog cov paj tau zoo yog nyob ntawm cov statins txij li nws tau luam ntawv.

Atorvastatin yog thawj qhov tshuaj ntawm qhov kev txiav txim no. Cov tshuaj tau tsim tawm hauv lub Yim Hli 1985 hauv Tebchaws Yelemees.

Statins yog cov tshuaj uas tsim los tawm tsam hypercholesterolemia, thiab atherosclerosis kev loj hlob yog qhov tshwm sim ntawm nws. Lawv qhov ua yog kho cov lipid profile ntsuas, kho cov teeb meem vascular phab ntsa thiab txo nws qhov o.

Cov nyhuv ntawm statins rau roj biosynthesis

Statins txo cov roj cholesterol los ntawm kev sib xyaw ua ke rau nws cov tshuaj lom neeg txoj sia hauv lub siab.

Rau kev nkag siab zoo ntawm qhov no, nws tsim nyog noj tag nrho cov txheej txheem rau theem.

Muaj ntau tshaj nees nkaum yam koom nrog hauv cov txheej txheem biosynthesis.

Rau qhov yooj yim ntawm kev kawm thiab kev nkag siab, tsuas muaj plaub ntu loj:

• thawj theem yog kev tsub zuj zuj ntawm muaj pes tsawg ntawm cov piam thaj hauv hepatocytes los pib qhov kev tawm tsam, tom qab ntawd cov enzyme HMG-CoA reductase pib muab tso rau hauv cov txheej txheem, nyob rau hauv kev cuam tshuam ntawm kev sib txuas uas hu ua mevalonate yog tsim los ntawm biotransformation,
• tom qab ntawd concentrated mevalonate koom nrog hauv cov txheej txheem phosphorylation, nws muaj nyob hauv kev hloov pauv ntawm phosphorus pawg thiab lawv ntes los ntawm adenosine tri-phosphate, rau cov synthesis ntawm lub zog,
• cov theem tom ntej - cov txheej txheem hws - nws muaj nyob rau hauv kev siv maj mam siv dej thiab kev hloov pauv ntawm mevalonate rau hauv squalene, thiab tom qab ntawd mus rau hauv lanosterol,
• mus rau lanosterol, los ntawm kev tsim kom muaj ob daim ntawv cog lus, cov pa roj carbon atom tau muab txuas - qhov no yog theem kawg ntawm kev tsim cov roj (cholesterol) uas tshwm sim hauv tshwj xeeb organelle ntawm hepatocytes - endoplasmic reticulum.

Statins cuam tshuam rau thawj theem ntawm kev hloov pauv, thaiv qhov enzyme HMG-CoA reductase thiab yuav luag tag nrho kev txiav mevalonate. Tus txheej txheem no yog tshwm sim rau tag nrho pawg. Yog li nws tau xub tsim los ntawm cov kws tshawb fawb German ntawm Pfizer hauv lub xyoo pua dhau los.

Tom qab ib xyoo caum ntawm kev sim tshuaj, statins tshwm sim hauv khw muag tshuaj. Thawj tus ntawm lawv yog qhov tshuaj xub pib Atorvastatin, qhov seem tau tshwm sim ntau tom qab thiab yog nws cov ntawv luam - cov no yog cov hu ua generics.

Tus txheej txheem ntawm kev ua haujlwm hauv lub cev

Tevastor yog plaub tiam statin muaj, raws li cov tshuaj nquag, rosuvastatin. Tevastor yog ib qho kev nyiam tshaj plaws los ntawm Atorvastatin hauv cov teb chaws CIS - nws cov neeg ua ntej.

Pharmacodynamics thiab pharmacokinetics piav qhia txog li cas Tevastor ua haujlwm tom qab nws nkag mus rau hauv tib neeg lub cev.

Kev nkag mus ntawm cov hnoos qeev hauv lub plab, cov yam khoom xyaw yog nqa los ntawm cov hlab ntshav thoob plaws lub cev thiab tsub zuj zuj hauv lub siab tom qab tsib teev.

Ib nrab-lub neej yog nees nkaum teev, uas txhais tau tias nws yuav siv sijhawm plaub caug teev los ua kom pom tseeb. Cov tshuaj no dhau los ntawm cov txheej txheem hauv ntuj - txoj hnyuv tshem tawm 90%, cov seem tshuav tawm los ntawm lub raum.

Nrog kev siv cov tshuaj tsis tu ncua, qhov siab tshaj plaws ua kom tau lub zog tshwm sim rau ib hlis tom qab pib kho.

Yog tias tus neeg mob muaj mob ntev, cov teeb meem pharmacokinetic hloov:

1. Nrog rau lub raum ua tsis zoo, thaum creatine tshem tawm txo 4 zaug los yog ntau dua, cov tshuaj ntawm rosuvastatin nce li 9 zaug. Hauv cov neeg mob rau mob hemodialysis, cov nqi no nce mus rau 45%,
2. Hauv kev ua haujlwm me thiab mob raum tsis ua haujlwm, thaum qhov kev tshem tawm yog siab dua 30 millilitres ib feeb, qhov kev nqus ntawm cov tshuaj hauv plasma tseem nyob ntawm cov tshuaj kho.
3. Nrog tsim lub siab tsis ua haujlwm, kev tshem tawm ib nrab ntawm lub neej nce ntxiv, uas yog, cov khoom siv cuam tshuam txuas mus ntxiv rau lub cev hauv cov ntshav. Qhov no tuaj yeem ua rau qaug dab peg, mob raum, thiab ua rau mob hnyav. Yog li, thaum kho, nws yuav tsum tau ua raws nraim li cov kws kho mob tau sau ntawv txhawm rau txhawm rau tiv thaiv, kom tsis txhob noj tshuaj ntau dhau thiab dhau sijhawm kom dhau cov kev tswj hwm,

Thaum siv cov tshuaj, nws yuav tsum nco ntsoov tias nyob rau hauv cov neeg ntawm cov haiv neeg Asian, qhov kev nthuav tawm ntawm rosuvastatin qeeb, yog li lawv yuav tsum tsuas yog cov tshuaj tsawg kawg nkaus.

Cov lus qhia rau kev siv tshuaj

Muaj ib daim ntawv teev qee qhov cim tseg ntawm kev siv tshuaj yeeb.

Tag nrho cov cim qhia tau qhia hauv cov lus qhia rau kev siv.

Cov lus qhia no yog ib qho tseem ceeb hauv kev ntim khoom ntawm cov tshuaj muag muag los ntawm cov khw muag tshuaj lub network.

Cov cim tseem ceeb rau kev siv tshuaj yog:

1. Lub Koom Haum Me Nyuam Yaus (nrog nws tsuas yog lipoproteins ntawm kev ntom ntom uas tau tsa tsawg) thiab sib xyaw (txhawb thiab lipoproteins ntawm qhov nruab nrab kom tsawg heev) hypercholesterolemia. Tab sis tsuas yog nyob rau hauv rooj plaub thaum qhov kev nce ntawm kev ua haujlwm hauv lub cev, tsis lees paub cov cwj pwm tsis zoo thiab kev noj zaub mov tsis tau coj cov yam xav ua,
2. Hypertriglycerinemia, thaum nce lipoproteins tsawg ntom, yog tias kev noj zaub mov tsis txig tsis txo cov roj cholesterol,
3. Atherosclerosis - txhawm rau ua kom cov nyiaj lipoprotein ntau dua cov kab mob siab ua rau lub siab ua kom cov tshuaj phem hauv cov roj cholesterol tsawg,
4. Txhawm rau tiv thaiv kev txhim kho cov hlab plawv muaj teeb meem ntawm atherosclerosis: mob myocardial infarction, ischemic stroke, angina pectoris, tshwj xeeb tshaj yog nyob rau ntawm qhov muaj feem phom sij - haus luam yeeb, haus cawv, rog dhau ntawm 50 xyoo.

Cov lus qhia rau kev siv tsim kev pom tseeb kev noj tshuaj rau txoj kev noj tshuaj.

Noj ntawm qhov ncauj, haus dej kom ntau, tsis hais noj dab tsi, tsis noj losyog tsoo. Nws raug nquahu kom haus thaum hmo ntuj, vim tias thaum nruab hnub, kev tshem tawm cov tshuaj kho sai, thiab nws cov dej ntau dhau los ntawm lub cev tawm.

Thawj qhov tshuaj yog 5 mg 1 zaug nyob rau ib hnub. Txhua lub hlis, nws yog qhov tsim nyog yuav tsum tswj hwm kev lipid thiab tus kws kho mob sab laj. Ua ntej pib kev kho mob, kws kho plawv yuav tsum sau cov lus qhia rau kev nkag mus kawm thiab piav qhia txog cov kev mob tshwm sim twg yuav tsum tsis txhob noj thiab nrhiav kev pab ntawm lub tsev kho mob.

Tsis tas li ntawd, txhua lub sijhawm ntawm kev kho, nws yog ib qho tsim nyog yuav tsum ua raws li kev noj zaub mov hypocholesterol, uas txhais tau hais tias nruj me ntsis txwv tsis pub kom muaj cov rog, zaub mov kib, qe, hmoov thiab zaub mov qab.

Mob pathological rau ntawm lub cev

Cov kev mob tshwm sim yog faib raws li qhov muaj ntau zaus uas muaj ntau zaus, tsawg thiab tsis tshua muaj heev.

Nquag - ib kis ntawm ib puas tus neeg - kiv taub hau, mob ntawm lub tuam tsev thiab caj dab, kev loj hlob ntawm hom 2 mob ntshav qab zib, xeev siab, ntuav, tso quav, mob leeg, mob asthenic,

Tsis tshua muaj - ib kis rau 1000 tus neeg - kev ua xua rau kev sib xyaw ntawm cov tshuaj los ntawm urticaria rau Quincke's edema, mob mob ua paug rau leeg (ua mob rau ntawm tus txiav), tawv nqaij ua pob, ua pob txha ua pob,

Muaj tsawg kawg - 1/10000 tus neeg mob - rhabdomyolysis tshwm sim, qhov no yog qhov kev rhuav tshem cov leeg nqaij nrog kev tso cov protein tawm mus rau hauv cov hlab ntshav thiab qhov tshwm sim ntawm lub raum tsis ua haujlwm.

Cov kev ua tsis txuam nrog kev siv tshuaj yog cov xwm txheej hauv qab no:

• Cev xeeb tub - Rosuvastatin yog cov tshuaj lom rau lub cev hauv plab ntau heev, vim los ntawm thaiv qhov kev sib xyaw ntawm cov cholesterol, nws cuam tshuam kev tsim ntawm phab ntsa. Qhov no, nyeg, yuav ua rau txoj kev loj hlob intrauterine qeeb qeeb, muaj ntau yam hauv nruab nrog cev, thiab ua pa nyuaj siab. Tus me nyuam hauv plab yuav tuag los yog yug los nrog cov lus tsis sib xws, yog li ntawd, nws tau hais kom siv lwm cov tshuaj los kho tus poj niam cev xeeb tub.
• Kev pub mis niam mis - qhov no tsis tau raug sim hauv qhov kev tshawb fawb hauv chav kho mob, yog li qhov kev pheej hmoo tsis tuaj yeem pom. Lub sijhawm no, cov tshuaj yuav tsum tau tso tseg.
• Cov menyuam yaus thiab tub ntxhais hluas vim tias qhov tsis zoo ua rau lub cev muaj peev xwm kis tau yam tsis zoo, yog li ntawd, kev nkag mus rau 18 xyoo txwv tsis pub muaj.
• Mob raum tsis ua haujlwm.
• Kab mob ntawm daim siab, mob ceev lossis mob ntev.
• Hauv kev laus, nws yog ib qhov tsim nyog yuav tsum tau muab tshuaj rau kom ceev faj. Pib noj tshuaj 5 mg, qhov ntau tshaj tsis pub tshaj 20 mg ib hnub nyob rau hauv kev saib xyuas mob nkeeg nruj.
• Tom qab hloov khoom nruab nrog vim kev tsis sib xws ntawm cyclosporine, uas txwv qhov tsis lees txais cov tshuaj tiv thaiv thiab rosuvastatin.
• Ua ke nrog cov tshuaj anticoagulants, txij li Tevastor potentiates lawv ua, nce prothrombin sijhawm. Qhov no tuaj yeem tiv thaiv nrog los ntshav sab hauv.
• Koj tsis tuaj yeem coj nws nrog lwm cov statins thiab hypocholesterolemic vim kev sib xyaw ntawm pharmacokinetics.
• Lactose thev tsis tau.

Ib qho ntxiv, nws raug txwv tsis pub noj tshuaj yog tias tus neeg mob tau txais tshuaj tiv thaiv tsis haum rau ib qho twg ntawm cov tshuaj.

Cov ntaub ntawv hais txog statins yog muab hauv video hauv tsab xov xwm no.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo. Nrhiav tsis pom. Nrhiav. Nrhiav tsis pom. Pom. Nrhiav tsis pom.