Mob ntshav qab zib thiab txhua yam hais txog nws

Qee tus neeg mob ntshav qab zib muaj kev ntxhov siab txog kev pw tsaug zog, thiab yog li ntawd, lawv yuav tsum xaiv cov tshuaj tsaug zog. Cov kev sab laj tshwm sim txog kev siv tshuaj Melaxen rau ntshav qab zib hom 1 thiab ntshav qab zib hom 2.

Hauv cov lus qhia rau kev siv cov tshuaj no, ib qho ntawm contraindications yog mob no. Nws ntseeg tias Melaxen tuaj yeem txo qis lossis nce ntshav qab zib ntxiv. Tab sis qee tus neeg mob ntshav qab zib noj cov tshuaj tsaug zog no thiab tsis yws txog lub xeev ntawm hypo- lossis hyperglycemia. Yuav ua li cas tiag tiag tshwm sim hauv lub cev ntawm cov ntshav qab zib tom qab noj cov tshuaj?

Kev xav txawv ntawm cov tshuaj no. Tab sis, txawm li cas los xij, hais txog cov txiaj ntsig ntawm kev tshawb nrhiav rov ua dua, peb tuaj yeem xaus tias, tsawg kawg, cov tshuaj Melaxen tsis cuam tshuam loj rau tib neeg lub cev uas muaj hom 1 lossis ntshav qab zib hom 2. Nws lub cev ua haujlwm, melatonin, yog qhov tseem ceeb hormone uas tswj ntau cov txheej txheem hauv tib neeg lub cev, tshwj xeeb tshaj yog biorhythms.

Yog li, kom tsis txhob muaj kev phom sij, nws yog qhov zoo tshaj plaws los sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj tsaug zog. Nws yuav yeej tuaj yeem txheeb xyuas qhov ua tau ntawm kev siv yeeb tshuaj thiab muab tshuaj kom yog.

Cov ntaub ntawv hais txog cov tshuaj Melaxen

Cov tshuaj yog siv rau kev pw tsaug zog thiab ua ib qho adaptogen kom ruaj khov lub biorhythm, piv txwv li, thaum mus ncig. Melaxen yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, txhua tus muaj melatonin (3 mg), ntxiv rau cov khoom siv ntxiv - magnesium stearate, microcrystalline cellulose, calcium hydrogen phosphate, shellac, talc thiab isopropanol.

Melatonin yog hom tshuaj tseem ceeb hauv lub caj pas pituitary thiab tus kws tswj ncig circadian (circadian) rhythms. Thaum lub sijhawm nws txoj kev txhim kho lossis siv ua tshuaj, melatonin ua cov haujlwm hauv tib neeg lub cev:

txo lub cev, lub hlwb thiab lub siab,
cuam tshuam cov kab mob endocrine (tshwj xeeb, inhibits kev zais cia ntawm gonadotropins),
normalizes ntshav siab thiab pw tsaug zog zaus,
nce antibody ntau lawm,
yog rau qee yam uas muaj cov tshuaj antioxidant,
cuam tshuam kev yoog raws lub sij hawm muaj kev hloov pauv ceev ntawm huab cua thiab thaj chaw caij,
tswj kev zom zaub mov thiab lub hlwb ua haujlwm,
qeeb tawm hauv cov laus txheej txheem thiab ntau ntxiv.

Kev siv cov tshuaj Melaxen tuaj yeem txwv tsis pub tsuas yog vim muaj hom 1 thiab ntshav qab zib hom 2, tab sis kuj tseem muaj qee qhov lwm qhov kev tiv thaiv:

ib tug neeg intolerance mus rau lub Cheebtsam,
gestation thiab lactation,
lub raum khiav tsis zoo thiab lub raum tsis ua haujlwm,
autoimmune pathologies,
mob vwm (mob hlwb),
myeloma (mob qog ua hlav los ntawm cov ntshav ntshav),
lymphoganulomatosis (malignant pathology ntawm lymphoid nqaij),
cov qog ntshav (cov qog ntshav o),
mob leukemia (mob hlwb ntawm cov ntshav hematopoietic),
kev fab tshuaj

Muaj qee kis, cov tshuaj muaj peev xwm ua rau muaj qee qhov xwm txheej tsis zoo xws li:

sawv ntxov ntxov tsaug zog thiab mob taub hau,
lub plab zom mov (xeev siab, ntuav, mob ntshav qab zib),
kev ua xua (o).

Melaxen tuaj yeem yuav tau hauv lub tsev muag tshuaj yam tsis muaj kws kho mob sau ntawv. Ntawm kev lag luam pharmacological ntawm Russia tseem muaj nws cov analogues - Melarena, Circadin, Melarithm.

Tab sis txawm li ntawd los, kev sab laj ntawm kws kho mob yuav tsis yog cov muaj txiaj ntsig, tshwj xeeb tshaj yog thaum ib tus neeg ib txwm lossis ntshav qab zib mob lwm yam kab mob.

Kev Txiav Txim Siab

Yog tias koj muaj ntshav qab zib uas xav noj tshuaj melatonin, sab laj nrog koj tus kws kho mob los txiav txim siab seb puas muaj lwm yam teeb meem uas koj yuav tsum tau saib xyuas. Koj tus kws kho mob yuav txiav txim siab txog koj hom ntshav qab zib, keeb kwm kho mob, thiab lwm yam tuaj nrog kev pom zoo. Lub koom haum American Diabetes Association qhia tias muaj cov kev mob tshwm sim, muaj txiaj ntsig, cuam tshuam rau kev siv yeeb tshuaj, thiab cov ntaub ntawv siv tshuaj rau cov tshuaj thiab cov tshuaj no tsis tas yuav to taub zoo, yog li nws yuav zoo rau nrhiav lwm cov kev kho rau koj cov teeb meem pw tsaug zog.

Cov tshuaj hormone melatonin ua haujlwm li cas?

Melatonin yog lub ntsiab pituitary hormone ua feem ntau hauv lub caj pas pineal. Nws cov khoom lag luam yog tshwm sim los ntawm poob ntawm kis rau lub teeb nrig ntawm tus kab mob retina. Yog li, nws qhia txog lub sijhawm ntawm nruab hnub, thiab tswj hwm circadian rhythms. Nws kuj tseem cuam tshuam cov kev voj voog hloov pauv hloov hauv kev siv ntawm cov txheej txheem ntawm ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg hauv lub cev, hloov lub voj voog circadian.

Tseeb, kev tswj hwm ntawm circadian atherosclerosis nyob rau ntau theem, suav nrog β - hlwb, koom nrog kev tswj metabolic, ntxiv rau kev txhim kho ntshav qab zib hom 2. Cov tshuaj hormones xa cov cim ntawm qib cellular siv ob lub receptors: (MT1) thiab (MT2). Ob lub receptors tsuas yog ua los ntawm Gαi protein, txo qis dua theem ntawm CAMP los ntawm kev txwv tsis pub muaj G (G I) cov protein, tab sis lwm cov kev qhia ntawm cov paib tseem siv. Pleiotropism nyob rau theem ntawm ob qho tib si receptors thiab lub teeb liab yam khoom siv theem ob. Qhov no piav qhia vim li cas qhov kev tshaj tawm cov teebmeem ntawm insulin tso tawm tsis muaj kev nkag siab meej txog lub luag haujlwm tswjhwm ntawm melatonin hauv insulin secretion. Yog li, lub inhibitory thiab txhawb cov teebmeem ntawm cov tshuaj no tau tshaj tawm tias muaj feem cuam tshuam rau insulin secretion.

Cov kev tshawb fawb tau qhia:

Tawm tsam ntawm cov keeb kwm yav dhau los no, peb pom tias MTNR1B (MT2) noob caj dab yog cuam tshuam nrog kev nce qib ntshav plasma ntshav qab zib ntau ntau. Kev poob qis thaum ntxov ntawm cov tshuaj insulin nrog kev tswj hwm ntshav qabzib, muaj kev cuam tshuam sai sai ntawm cov tshuaj insulin nyob rau lub sijhawm, thiab kev pheej hmoo ntawm kev tsim hom ntshav qab zib 2 nyob rau yav tom ntej. Txawm hais tias muaj qib siab heev ntawm kev sib txuas caj ces, kev nkag siab molecular ntawm vim li cas melatonin signaling tau koom nrog pathogenesis ntawm hom 2 ntshav qab zib tseem tsis tau tiav.

Yuav kom daws tau qhov teeb meem no, peb tau ua qhov kev sim tshawb fawb hauv tib neeg - hlwb thiab nas, nrog rau kev tshawb fawb soj ntsuam hauv tib neeg. Nws muab tawm tias qhov kev pheej hmoo sib txawv rs 10830963 los ntawm MTNR1B yog ib qho kev hais tawm ntawm cov lus muaj nuj nqis (eQTL) cuam tshuam rau kev nthuav qhia ntawm MTNR1B mRNA nyob rau hauv tib neeg islets. Cov kev sim hauv INS-1 832/13 cells-cov hlwb thiab MT2 ntawm kev sim cov nas (Mt2 - / -) pom tias kev cuam tshuam ntawm cov tshuaj melatonin ncaj qha cuam tshuam rau cov teeb meem ntawm insulin tso.

Kev tshawb nrhiav tib neeg qhia tias kev kho melatonin kho qhov tsis txawv ntawm cov tshuaj insulin rau txhua tus neeg mob. Tab sis cov neeg nqa khoom ntawm cov kev pheej hmoo loj muaj peev xwm nkag siab ntau dua rau cov nyhuv inhibitory. Ua ke, cov kev soj ntsuam no txhawb nqa tus qauv uas qhov kev txiav txim siab tau nce zuj zus hauv melatonin signaling underlies insulin secretion. Muaj kev cuam tshuam uas xa cov kab mob ntshav qab zib hom 2 mob ntshav qab zib.

Abstract ntawm cov ntawv xov xwm scientific txog tshuaj kho mob thiab kev kho mob, tus sau ntawv muaj ntawv pov thawj kev tshawb fawb - Konenkov Vladimir Iosifovich, Klimontov Vadim Valerievich, Michurina Svetlana Viktorovna, Prudnikova Marina Alekseevna, Ishenko Irina Yurievna

Cov tshuaj hormones ntawm lub caj pas pineal melatonin ua rau lub zog ua haujlwm ntawm insulin secretion thiab qabzib homeostasis nrog kev sib hloov lub teeb thiab tsaus lub sijhawm. Kev ua txhaum ntawm kev sib koom tes ntawm melatonin-mediated circadian rhythms thiab insulin secretion tau pom nyob hauv hom 1 thiab hom 2 ntshav qab zib mellitus (T1DM) thiab T2DM. Cov tshuaj insulin nyob hauv ntshav qab zib hom 1 yog nrog kev nce ntxiv hauv kev tsim cov melatonin hauv lub raum pineal. T2DM, qhov tsis sib xws, yog tus yam ntxwv los ntawm kev txo qis melatonin secretion. Hauv cov kev tshawb fawb genome-dav, hloov pauv ntawm melatonin MT2 receptor gene (rs1387153 thiab rs10830963) yog txuam nrog kev yoo mov glycemia, β-cell muaj nuj nqi, thiab hom 2 mob ntshav qab zib. Melatonin nce β-cell ntau zuj zus thiab neogenesis, txhim kho insulin rhiab heev thiab txo qis oxidative kev nyuaj siab nyob rau hauv retina thiab raum hauv kev sim ntshav qab zib ua qauv. Cov kev tshawb fawb txuas ntxiv yog xav tau los soj ntsuam qhov txiaj ntsig kho tus kabmob no hauv cov neeg mob ntshav qab zib.

Melatonin thiab ntshav qab zib: los ntawm pathophysiology rau txoj kev kho mob

Pineal hormone melatonin synchronizes insulin secretion thiab qabzib homeostasis nrog lub hnub. Kev tsis sib xws ntawm melatoninmediated circadian rhythms thiab insulin secretion cim cov ntshav qab zib mellitus hom 1 (T1DM) thiab hom 2 (T2DM). Cov tshuaj insulin nyob hauv T1DM yog los ntawm kev ua kom cov melatonin ntau lawm. Hloov pauv, T2DM yog tus cwj pwm los ntawm kev ploj zuj zus melatonin secretion. Hauv kev koom tes ntawm cov genome kawm cov kev hloov pauv ntawm melatonin receptor MT2 gene (rs1387153 thiab rs10830963) tau cuam tshuam nrog kev yoo qab zib, beta-cell ua haujlwm thiab T2DM. Hauv kev sim ua qauv ntawm cov ntshav qab zib melatonin txhim kho beta-cell proliferation thiab neogenesis, txhim kho insulin tsis kam thiab txo qis oxidative kev nyuaj siab hauv retina thiab raum. Txawm li cas los xij, kev tshawb nrhiav ntxiv yuav tsum los ntsuam xyuas cov nqi kho mob ntawm melatonin hauv cov neeg mob ntshav qab zib.

Cov ntawv sau ntawm cov haujlwm scientific hauv lub ntsiab lus "Melatonin hauv ntshav qab zib mellitus: los ntawm pathophysiology rau kev kho mob kev cia siab"

Melatonin hauv ntshav qab zib: los ntawm pathophysiology rau kev kho mob kev cia siab

Konenkov V.I., Klimontov V.V., Michurina S.V., Prudnikova M.A., Ischenko I.Yu.

Tshawb fawb lub koom haum saib xyuas mob thiab kev sim ntawm cov nkauj, Novosibirsk

(Tus Thawj Coj - Tus Neeg Kawm RAMNV.I. Konenkov)

Cov tshuaj hormones ntawm lub caj pas pineal melatonin ua rau lub zog ua haujlwm ntawm insulin secretion thiab qabzib homeostasis nrog kev sib hloov lub teeb thiab tsaus lub sijhawm. Kev ua txhaum ntawm kev sib koom tes ntawm melatonin-mediated circadian rhythms thiab insulin secretion tau pom nyob hauv hom 1 thiab hom 2 ntshav qab zib mellitus (T1DM) thiab T2DM. Cov tshuaj insulin nyob hauv ntshav qab zib hom 1 yog nrog kev nce ntxiv hauv kev tsim cov melatonin hauv lub raum pineal. T2DM, qhov tsis sib xws, yog tus yam ntxwv los ntawm kev txo qis melatonin secretion. Hauv cov kev tshawb fawb tag nrho, kev hloov pauv ntawm cov melatonin MT2 receptor gene (rs1387153 thiab rs10830963) muaj feem cuam tshuam nrog kev yoo mov glycemia, kev ua haujlwm (i-hlwb thiab CD2. Melatonin nce kev loj hlob thiab neogenesis (i-hlwb, txhim kho insulin rhiab heev thiab txo qis oxidative kev nyuaj siab hauv retina thiab raum hauv lub raum. cov qauv sim ntshav qab zib Yuav kom ntsuas qhov ntsuas tus nqi ntawm cov tshuaj no hauv cov neeg mob ntshav qab zib, kev tshawb fawb ntxiv yog xav tau.

Cov lus tseem ceeb: mob ntshav qab zib mellitus, melatonin, circadian rhythms, insulin, lub caj pas pineal

Melatonin thiab ntshav qab zib: los ntawm pathophysiology rau txoj kev kho mob

Konenkov V.I., Klimontov V.V., Michurina S.V., Prudnikova M.A., Ishenko I.Ju.

Tshawb fawb lub koom haum saib xyuas mob thiab sim ua suab paj nruag, Novosibirsk, Lavxias Federation

Pineal hormone melatonin synchronizes insulin secretion thiab qabzib homeostasis nrog lub hnub. Kev tsis sib xws ntawm melatonin-mediated circadian rhythms thiab insulin secretion cim cov ntshav qab zib mellitus hom 1 (T1DM) thiab hom 2 (T2DM). Cov tshuaj insulin nyob hauv T1DM yog los ntawm kev ua kom cov melatonin ntau lawm. Hloov pauv, T2DM yog tus cwj pwm los ntawm kev ploj zuj zus melatonin secretion. Hauv kev koom tes ntawm cov genome kawm cov kev hloov pauv ntawm melatonin receptor MT2 gene (rs1387153 thiab rs10830963) tau cuam tshuam nrog kev yoo qab zib, beta-cell ua haujlwm thiab T2DM. Hauv kev sim ua qauv ntawm cov ntshav qab zib melatonin txhim kho beta-cell proliferation thiab neogenesis, txhim kho insulin tsis kam thiab txo qis oxidative kev nyuaj siab hauv retina thiab raum. Txawm li cas los xij, kev tshawb nrhiav ntxiv yuav tsum los ntsuam xyuas cov nqi kho mob ntawm melatonin hauv cov neeg mob ntshav qab zib.

Cov ntsiab lus: ntshav qab zib, melatonin, circadian rhythms, insulin, epiphysis

Biorhythms ntawm cov kab mob endocrine, nrog rau lawv cov kev hloov pauv ntawm cov xwm txheej ntawm pathology, tau nyiam cov kws tshawb fawb tau siv ntau xyoo lawm. Lub hom phiaj ntawm kev txaus siab tshwj xeeb hauv kev kawm txog ntshav qab zib mellitus (DM) los ntawm qhov pom ntawm chronomedicine yog pineal caj pas hormone melatonin. Cov tshuaj hormones no ua lub luag haujlwm tseem ceeb nyob rau hauv kev ua haujlwm ntawm cov tshuaj hormones stimuli thiab cov txheej txheem hauv lub cev nrog kev hloov ntawm lub teeb thiab tsaus. Xyoo tsis ntev los no, cov ntsiab lus tshiab tau txais ntawm lub luag haujlwm ntawm melatonin hauv kev tswj hwm ntawm insulin secretion thiab pathophysiology ntawm carbohydrate metabolism cuam tshuam, thiab kev cia siab rau kev siv melatonin rau kev kho mob ntshav qab zib yog sib tham. Qhov dav dav ntawm cov ntaub ntawv no yog lub hom phiaj ntawm txoj kev ntsuam xyuas no.

Cov teeb meem sib xyaw nrog thiab cov teebmeem kev mob tshwm sim ntawm melatonin

Cov tshuaj hormones melatonin tau cais tawm ntawm bovine pineal caj pas cov khoom siv hauv 1958. Melatonin yog tsim los ntawm L-tryptophan los ntawm serotonin nrog kev koom tes ntawm arylalkylamine-Acetyltransferase (AA-NAT, enzyme tseem ceeb) thiab hydroxyindole-O-methyltransferase. Hauv cov laus, li 30 mcg yuav ua haujlwm ib hnub

melatonin, nws cov concentration hauv cov ntshav cov ntshav thaum hmo ntuj yog 20 npaug ntau dua thaum nruab hnub. Kev sib luag circadian ntawm melatonin synthesis yog tswj los ntawm suprachiasmatic nucleus (SCN) ntawm hypothalamus. Tau txais cov ntaub ntawv hais txog kev hloov pauv ntawm lub teeb pom kev zoo los ntawm qhov retina, SCN xa cov lus taw qhia los ntawm kev mob siab rau lub tsev menyuam zoo thiab cov leeg norarenergic rau lub caj pas pineal. Kev ua kom mob ntawm epiphyseal β1-adrenergic receptors inhibits AA-NAT cleavage thiab nce melatonin synthesis.

Ntxiv rau lub caj pas pineal, melatonin ntau lawm tau pom nyob rau hauv cov hlwb neuroendocrine ntawm cov kab mob retina, nkag mus rau hauv lub hlwb ntawm cov hlab ntsha (EC hlwb), cov hlab ntsha ntawm lub hlab pa, thymus, qog adrenal, paraganglia, mob hlab ntsws, thiab lwm hom hlwb muaj feem rau qhov kev tiv thaiv kab mob neuroendocrine. Cov qe ntshav dawb, platelets, endotheliocytes, raum cortex hlwb thiab lwm cov qe ntshav tsis txaus hauv lub hlwb kuj tseem tuaj yeem tsim cov melatonin. Lub hauv paus tseem ceeb ntawm kev nthuav tawm melatonin yog lub caj pas pineal. Cov lus sib dhos ntawm melatonin secretion, uas ua ke nrog kev sib dhos ntawm lub teeb-tsaus ntuj, tsuas yog cov yam ntxwv tsuas yog ntawm lub caj pas pineal thiab retina.

Lub cev muaj peev xwm ntawm melatonin yog kho kom haum los ntawm daim nyias nyias thiab cov tshuaj nuclear. Ntawm tus neeg

xyoo pua pom 2 hom receptors rau melatonin: MT1 (MTNR1A) thiab MT2 (MTNR1B). MT2 receptors pom nyob rau hauv retina, ntau qhov chaw hauv lub hlwb, thiab nws ntseeg tau tias nws yog dhau ntawm lawv tias circadian rhythms raug tsim. Lub luag haujlwm tseem ceeb ntawm melatonin yog los ua kom lub zog ntawm cov cev nqaij daim tawv thiab lub cev nrog cov kev ua haujlwm txhua hnub thiab lub caij 5, 6. Qhov tshwj xeeb, kev zais cia ntawm melatonin cuam tshuam cov kev cuam tshuam ntawm cov hlab plawv, lub cev tsis muaj zog, thiab endocrine system.

Cov nyhuv ntawm melatonin ntawm insulin secretion thiab qabzib homeostasis

Qhov pom tseeb tsis sib xws ntawm lub circadian rhythms ntawm lub zais cia ntawm melatonin thiab insulin yog txuam nrog kev sib txawv hauv cov kev ua haujlwm lom hauv cov tshuaj hormones no. Hauv kev sib piv rau melatonin, qhov qis tshaj plaws ntawm insulin hauv tib neeg yog pom thaum hmo ntuj, txij li lub luag haujlwm tseem ceeb ntawm insulin - kev tswj cov metabolism hauv cov zaub mov tom qab lub xeev, yuav tsum tsis txhob pom kev thaum hmo ntuj. Nws tau qhia tias qhov kev ua txhaum ntawm ib qho kev sib txuas ntawm cov zaub mov thiab lub sijhawm ntawm ib hnub nrog kev hloov ntawm cov zaub mov li qub los ntawm 12 teev yog nrog los ntawm kev nce insulin ntau ntxiv hauv cov neeg ua haujlwm pub dawb. Melatonin saib xyuas cov synchronization ntawm cov khoom noj hauv cov txheej txheem nrog hmo ntuj, i.e. lub sijhawm ua haujlwm los ntawm tus neeg ua rau yoo mov, thiab tuaj yeem muaj qhov cuam tshuam ntawm cov tshuaj insulin zais cia.

Qhov tseeb ntawm kev hais tawm ntawm MT-1 thiab MT-2 melatonin receptors hauv pancreatic islets hauv nas thiab nas tau tsim muaj. Hauv tib neeg islets, MT1 thiab, kom tsawg dua, MT2 receptors 12, 13 qhia. Cov lus qhia ntawm M ^ receptors yog cov yam ntxwv feem ntau ntawm cov-11, 12, MT2 receptors muaj nyob hauv p-hlwb 11, 13, 14. Kev sim hauv vitro qhia txog cov tshuaj tiv thaiv kev tsis haum ntawm melatonin ntawm insulin secretion hauv p hlwb, nas insulinoma hlwb (MIN-6), thiab nas (INS-1). Txawm li cas los xij, nyob rau hauv kev muaj sia nyob hauv ib qhov tseem ceeb, cov nyhuv ntawm melatonin yuav tsis muaj nuj nqis. Melatonin tau pom tias ua rau lub zais tsis sib haum ntawm ob hom glucagon thiab insulin hauv cov tshuaj pleev rau tib neeg islets. Nws tau tshaj tawm tias tsis muaj kev cuam tshuam ntawm melatonin ntawm insulin secretion hauv islets ntawm ob / ob nas (cov qauv rog thiab hom 2 mob ntshav qab zib (ntshav qab zib hom 2)). Qhov tsis meej xwm ntawm cov nyhuv ntawm melatonin tau pom meej piav qhia los ntawm ntau yam ntawm cov cim taw qhia los ntawm kev uas nws cov teebmeem raug kho. Cov nyhuv inhibitory melatonin ntawm insulin ntau lawm cuam tshuam nrog kev cuam tshuam ntawm cAMP thiab cGMP-txoj hauv kev, thiab cov nyhuv stimulating yog sib kho los ntawm 0 (d) -proteins, phospholipase C thiab IP.

Cov kev hloov pauv hauv insulin secretion thiab glucose homeostasis tau pom hauv cov tsiaj txhu nrog lub qog pineal tawm. Nws tau qhia tias pinealectomy hauv nas ua rau insulin tsis kam ua haujlwm ntawm lub siab, ua haujlwm ntawm gluconeogenesis thiab nce ntxiv ntawm glycemia thaum hmo ntuj. Muaj piam thaj ntau-lub sij hawm tso cov kua ntshav hauv insulin thiab

Mob ntshav qab zib mellitus. 2013, (2): 11-16

qhov nce ntxiv ntawm qhov ntau ntawm nws cov lus sib dhos tau kuaj pom hauv cov kab mob hauv cov hlwb ua nas rau kev tiv thaiv pinealectomy. Kev tshem tawm ntawm lub caj pas pineal hauv cov nas nrog T2DM tus qauv (OLETF kab) ua rau hyperinsulinemia thiab cov tsub zuj zuj ntawm triglycerides hauv lub siab. Nws tau hais tias niam melatonin tuaj yeem ua lub circadian rhythms ntawm lub zog metabolism hauv kev xeeb tub. Hauv cov xeeb ntxwv ntawm cov nas uas ua rau muaj kev ua thuv-pliag, qhov txo qis hauv qabzib insulin secretion, insulin tsis kam ntawm daim siab thiab, vim li ntawd, muaj kev cuam tshuam cov ntshav qabzib thaum kawg ntawm lub sijhawm nruab hnub.

Hauv cov neeg mob uas mob ntshav lub plawv, qhov kev txo qis ntawm nocturnal secretion ntawm melatonin yog txuam nrog kev nce ntawm cov kab mob insulin sai sai thiab nrog HOMA insulin kuj tiv thaiv kev ntsuas.

Yog li, nws zoo li tias melatonin pab txhawb rau kev tsim cov qib siab zoo tshaj plaws ntawm lub zog metabolism hauv cov neeg mob uas tsis muaj kev zais cia thiab siab rhiab rau insulin thaum hmo ntuj.

Melatonin receptor gene polymorphism thiab ntshav qab zib pheej hmoo

Cov txiaj ntsig ntawm kev tshawb nrhiav keeb kwm molecular tau pom tias muaj kev sib raug zoo ntawm polymorphic variants ntawm melatonin receptor genes thiab kev loj hlob ntawm cov ntshav qab zib hom 2. Ob qhov sib txawv ntawm ib qho nucleotide polymorphism ntawm MT2 gene (MTYB.1B): gb1387153 thiab gb10830963 muaj feem xyuam nrog kev yoo mov glycemia, insulin secretion thiab T2DM hauv cov neeg European. Nws tau tsim tsa hais tias qhov muaj ntawm T allele ntawm thaj chaw GB 13 8 715 3 yog txuam nrog kev yoo ntshav plasma (B = 0.06 mmol / L) thiab qhov kev pheej hmoo ntawm kev tsim hyperglycemia lossis T2DM (0H = 1.2). Kev tsom xam ntawm kaum qhov kev tshawb fawb genome qhia tau hais tias muaj txhua qhov G allele ntawm gb10830963 thaj chaw ntawm MTYB.1B noob yog cuam tshuam nrog kev nce ceev ntawm glycemia los ntawm 0.07 mmol / L, nrog rau kev txo qis ntawm b-cell ua haujlwm, kwv yees los ntawm HOMA-B index. Kev soj xyuas meta-13 ntawm cov kev tshawb fawb nrog qhov kev tsim qauv qhov teeb meem pom tau hais tias muaj G G allele ntawm cov chaw no nce qhov kev pheej hmoo ntawm kev tsim T2DM (0H = 1.09).

Yog li, MTYB.1B lub noob tuaj yeem raug suav hais tias yog qhov pib tshiab ntawm kev hloov caj ces rau T2DM. Cov theem ntawm kev cuam tshuam ntawm cov kabmob MTIV.1B ntawm kev pheej hmoo ntawm kev txhim kho tus kabmob yog coj tus mob, txawm li cas los xij, nws yog qhov sib piv nrog cov txiaj ntsig ntawm lwm cov "diabetogenic" genes. Ntau yam cuam tshuam nrog kev pheej hmoo mob ntshav qab zib yog kev sib txuas ua ke ntawm cov caj ces, suav nrog MTIV.1B thiab lwm yam muaj feem cuam tshuam nrog kev yoo qab zib: OSK, OKKYA, O6RS2 25, 26.

Hloov pauv yam tsis pub lwm tus noj melatonin hauv ntshav qab zib

Kev tsis sib haum ntawm melatonin secretion tau pom nyob rau hauv kev laus thiab ntau tus tib neeg cov kab mob, nrog rau lub caij nyoog kev cuam tshuam thiab kev puas siab puas ntsws bipolar.

Mob ntshav qab zib mellitus. 2013, (2): 11-16

stv, dementia, pw ntxhov, pw tsaug zog syndromes, malignant neoplasms. Cov kev pauv hloov nyuaj hauv cov zais cia ntawm melatonin yog yam ntxwv mob ntshav qab zib. Hauv cov qauv ntawm T1DM hauv tsiaj, kev nce qib hauv melatonin hauv cov ntshav tau qhia, ntxiv rau qhov nce ntawm cov lus hais ntawm cov kev tswj hwm enzyme AA-NAT hauv lub caj pas pineal 17, 27, 28. Hauv cov caj pas pineal ntawm cov tsiaj nrog insulin tsis txaus, kev qhia ntawm insulin receptors, B1-adrenoreceptors, thiab circadian PER1 noob. thiab BMAL1. Kev qhia txog cov tshuaj insulin hauv cov qauv ntshav qab zib no ua rau muaj qhov tsis sib luag ntawm qib melatonin hauv cov ntshav thiab cov noob keeb hauv qhov ncauj tawm ntawm lub caj pas pineal.

Lwm yam kev hloov pauv hauv melatonin ntau lawm tau pom hauv T2DM. Hauv Goto Kakizaki nas (cov caj ces ntawm T2DM), qhov txo qis hauv insulin receptor qhia tawm thiab AA-NAT cov haujlwm hauv lub caj pas pineal tau pom. Cov neeg mob uas muaj ntshav qab zib hom 2 muaj qee theem txo melatonin hauv cov ntshav. Cov kev tshawb fawb nrog kev ntsuas ntshav ib teev qhia kev txo qis ntawm nocturnal secretion ntawm melatonin rau cov txiv neej muaj ntshav qab zib hom 2. Hauv cov neeg mob uas mob metabolic syndrome, kev ua txhaum ntawm melatonin secretion tau tshwm sim, ua rau pom qhov tsis muaj lub zog ntawm lub zog hauv qhov kev tshem tawm ntawm metabolite ntawm melatonin 6-hydroxymelatonin sulfate (6-COMT) nrog zis thaum hmo ntuj. Lwm tus sau phau ntawv, qhov tsis sib xws, qhia hyperexcretion ntawm 6-COMT rau cov neeg mob uas muaj kev puas siab ntsws metabolic. Qhov feem ntau ntawm melatonin / insulin hauv ntshav plasma noj thaum 3 teev tsaus ntuj hauv cov neeg mob uas muaj kev puas siab ntsws metabolic tau txo qis. Qhov sib txawv nyob hauv nruab nrab hmo ntuj thiab nruab hnub ntawm melatonin tau rov qab sib txuam nrog kev yoo mov glycemia.

Tsis muaj feem ntau paub txog kev hloov pauv hauv cov yeeb yaj kiab melatonin hauv ntshav qab zib. Nws tau qhia tias hauv nas nrog kabmob ntshav qab zib streptozotocin, qib melatonin thiab kev ua haujlwm ntawm AA-NAT hauv qhov retina raug txo qis, thiab kev tswj hwm ntawm insulin tshem tawm cov kev cuam tshuam no. Kev hloov pauv coj los ua ke ntawm melatonin nyob rau hauv retina hauv cov ntshav qab zib retinopathy tsis tau kawm. Plasma melatonin concentration hauv cov neeg mob ntshav qab zib hom 2 nrog cov ntshav qabzib feem ntau retinopathy muaj tsawg dua li cov neeg mob yam tsis muaj kev cuam tshuam no.

Yog li, hom ntshav qab zib tseem ceeb tau tshwm sim los ntawm cov kev hloov pauv ntau ntawm kev tso cia ntawm melatonin nyob rau hauv lub caj pas pineal thiab qhov concentration ntawm melatonin hauv cov ntshav. Hauv ob hom ntshav qab zib, ib qho kev sib raug zoo muaj nyob nruab nrab ntawm kev tsim cov tshuaj insulin thiab melatonin, uas qhia txog qhov muaj kev sib raug zoo ntawm cov tshuaj hormones no.

Cov zeem muag rau kev siv melatonin hauv ntshav qab zib

Qhov tshwm sim ntawm melatonin ntawm kev txhim kho hom 1 ntshav qab zib tau kawm hauv kev sim. Melatonin tau pom tias nce nce ntxiv ntawm b-hlwb thiab ntshav insulin ntau ntau hauv cov nas uas muaj ntshav qab zib streptozotocin. Ntxiv nrog rau qhov kev txhawb nqa loj ntawm p-hlwb, melatonin inhibits lawv apoptosis thiab tseem txhawb kev tsim cov tshiab

islets los ntawm ductal epithelium ntawm lub txiav. Hauv cov qauv ntawm cov ntshav qab zib mellitus ntxias los ntawm streptozotocin hauv cov nas nyob rau lub sijhawm neonatal, melatonin tsis cuam tshuam rau insulin secretion, tab sis nce insulin rhiab heev thiab txo glycemia. Cov kev tiv thaiv zoo ntawm melatonin ntawm b hlwb yuav yog vim, tsawg kawg ntawm ib feem, ua rau cov antioxidant thiab immunomodulatory cuam tshuam. Nws tau raug pov thawj tias nyob hauv cov tsiaj muaj ntshav qab zib, melatonin muaj qhov sib txawv antioxidant thiab pab thim rov qab kev cuam tshuam kev cuam tshuam ntawm antioxidants. Cov nyhuv inhibitory ntawm melatonin ntawm Th1 lymphocytes ua kom lub neej ntawm kev hloov cov islet hauv NOD nas.

Kev siv cov melatonin hauv CD2 tus qauv thiab cov metabolism hauv kev puas siab ntsws (Zucker nas) tau los nrog kev txo qis sai ntawm glycemia, glycated hemoglobin (HbA1c), cov roj ntsha dawb, insulin, insulin resistance index (HOMA-IR) thiab cov tshuaj cytokines nyob rau hauv cov ntshav. Ntxiv rau, melatonin txo qis qis leptin ntau ntau thiab nce adiponectin ntau ntau. Cov ntaub ntawv no qhia tias melatonin muaj txiaj ntsig zoo rau adipose cov ntaub so ntswg ua haujlwm, mob ntev, insulin rhiab heev, carbohydrate thiab rog metabolism 40, 41. Melatonin pab txhawb kev hnyav hauv cov tsiaj qauv ntawm kev rog. Raws li kev tshawb fawb tsis raug tshawb fawb, noj melatonin nyob rau hauv cov neeg mob uas muaj kev puas siab ntsws metabolic yog nrog kev poob qis hauv cov ntshav siab, cov cim ntawm oxidative kev nyuab siab, HOMA-IR thiab qib roj cholesterol. Kev tswj hwm ntawm lub sijhawm ntev ua yeeb yaj kiab melatonin rau kev kho tus neeg tsis txaus ntseeg hauv cov neeg mob ntshav qab zib hom 2 tsis cuam tshuam txog qib ntawm insulin thiab C-peptide thiab tau nrog los txo HbA1c tom qab 5 lub hlis. kev kho.

Muaj cov pov thawj ntawm cov nyhuv ntawm melatonin ntawm kev txhim kho vascular cov teeb meem ntshav qab zib. Melatonin tiv thaiv kev ua haujlwm ntawm lipid peroxidation cov txheej txheem hauv retina 45, 46, txhim kho cov khoom siv electrophysiological thiab txo qis tsim cov vascular endothelial kev loj hlob yam (VEGF) hauv retina hauv hyperglycemia. Kev tswj cov melatonin rau cov nas uas muaj kabmob ntshav qab zib streptozotocin tiv thaiv kev loj hlob ntawm cov zis tso zis ntawm albumin 47, 48. Hauv lub raum ntawm cov tsiaj nrog ntshav qab zib, melatonin txo oxidative kev nyuaj siab thiab inhibits synthesis ntawm fibrogenic yam: TGF-r, fibronectin. Nyob rau hauv cov xwm txheej ntawm oxidative kev nyuaj siab thiab mob, qhov hormone muaj qhov cuam tshuam ntawm endothelium. Melatonin txum rov qab endothelium-aortic dilatation, cuam tshuam hauv hyperglycemia. Cov kab mob antioxidant ntawm melatonin hauv cov leeg pob txha yog los ntawm kev nce rau hauv qib ntawm circulating endothelial progenitor hlwb hauv cov nas uas muaj ntshav qab zib streptozotocin. Cov ntaub ntawv no yog qhov tsis xav pom, vim tias mob ntshav qab zib yog tus cwj pwm los ntawm kev tsis taus los ntawm cov hlwb los ntawm cov hlwb pob txha.

Hauv cov neeg mob uas muaj ntshav qab zib hom 1, melatonin nce qib ntawm hmo ntuj txo hauv cov ntshav cov ntshav diastolic. Qhov kev txiav txim siab tom qab yuav muaj txiaj ntsig zoo nyob rau ntawm cov ntshav qab zib mob ntshav qab zib neonpathy cuam tshuam nrog kev poob qis hauv kev ua haujlwm ntawm lub cev txo qis hauv ntshav thaum hmo ntuj.

Cov ntaub ntawv nthuav tawm qhia lub luag haujlwm tseem ceeb ntawm melatonin hauv txoj cai ntawm circadian rhythms ntawm kev zais

Mob ntshav qab zib mellitus. 2013, (2): 11-16

tshuaj insulin thiab ntshav qabzib homeostasis. Txog ntshav qab zib, kev ua txhaum ntawm circadian tsim tawm ntawm melatonin nyob rau hauv lub pineal caj pas thiab concentration ntawm melatonin nyob rau hauv cov ntshav yog cov yam ntxwv. Cov ntaub ntawv sim qhia hais tias melatonin tuaj yeem txo β-cell kev ua haujlwm, ncua kev txhim kho ntshav qab zib thiab nws cov teeb meem. Lub luag haujlwm ntawm pathophysiological ntawm kev tsis txaus siab nyob rau hauv kev zais cia ntawm melatonin hauv ntshav qab zib thiab kev siv tshuaj los kho cov tshuaj no tseem tsim nyog tshawb nrhiav ntxiv.

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Konenkov Vladimir Iosifovich Klimontov Vadim Valerevich

Michurina Svetlana Viktorovna Prudnikova Marina Alekseevna Ishchenko Irina Yurievna

Kev Kawm ntawm RAMS, MD, kws tshaj lij, tus thawj coj, FSBI Kev Tshawb Fawb Lub Chaw Haujlwm ntawm Kev Soj Ntsuam thiab Kev Ua Haujlwm Lymphology, Novosibirsk

MD, Lub Taub Hau Lub chaw kuaj ntshav ntawm Endocrinology, FSBI Tshawb Fawb Lub Chaw Haujlwm ntawm Chaw Soj Ntsuam thiab Kev Kawm Qib Siab, Novosibirsk E-mail: [email protected]

Kws kho mob tshuaj, Cov xibfwb, Cov kws kho mob ntawm Science Lub chaw kuaj mob ntawm Kev Tshawb Fawb ntawm Lymphatic System, FSBI Kev Tshawb Fawb Lub Chaw Haujlwm ntawm Kev Tshawb Fawb thiab Kuaj Mob Lymphology, Novosibirsk Kuaj ntawm Endocrinology, FSBI Kev Tshawb Fawb Lub Chaw Haujlwm ntawm Chaw Soj Ntsuam thiab Kws Lymphology, Novosibirsk

Ph.D., Tshawb Nrhiav Cov Laus lub chaw soj nstuam ntawm kev ua haujlwm morphology ntawm lub lymphatic system,

Tshawb fawb lub koom haum saib xyuas mob thiab kev sim ntawm cov nkauj, Novosibirsk