Rosuvastatin lossis Atorvastatin - uas zoo dua? Sab saum toj 5 tseeb!

Cov roj (cholesterol) siab yog qhov ua rau ntau yam kab mob hauv lub plawv, lub paj hlwb, cov hlab ntsha ib puag ncig. Atherosclerosis (kev tso tawm ntawm cov cholesterol nyob hauv phab ntsa ntawm cov hlab ntsha) yog qhov ua rau ploj tuag nyob hauv lub ntiaj teb thiab cov tebchaws ntawm lub sijhawm qub Soviet. Statins yog cov tshuaj uas tuaj yeem tiv taus, thiab nrog kev siv lub sijhawm ntev, tso tseg kev txhim kho ntawm atherosclerosis. Kev sib piv ntawm Atorvastatin thiab Rosuvastatin, ua ob tus neeg sawv cev zoo tshaj plaws ntawm pawg neeg no, yuav cia koj xaiv ib cov tshuaj rau txhua tus.

Atorvastatin thiab rosuvastatin muaj tib cov khoom xyaw nquag.

Mechanism ntawm kev ua

Tag nrho ob qho tshuaj yog cov neeg sawv cev ntawm tib pab pawg neeg muag tshuaj, thiab vim li ntawd lawv cov kev coj ua ntawm cov haujlwm zoo sib xws. Qhov sib txawv ntawm lawv yog nyob rau hauv lub zog ntawm kev nqis tes: kom ua tiav cov txiaj ntsig zoo ib yam, kev txhaj tshuaj ntawm Rosuvastatin tej zaum yuav yog ib nrab ntawm Atorvastatin.

Tus txheej txheem ntawm kev ua ntawm cov tshuaj yog txhawm rau txhawm rau qhov enzyme koom nrog kev tsim cov txheej txheem ua ntej ntawm cov cholesterol. Raws li qhov txiaj ntsig, theem ntawm tag nrho cov roj (cholesterol) thiab cov qis lipoproteins tsawg heev (LDL, VLDL), triglycerides tsawg dua. Lawv yog cov ua rau kev tsim cov quav hniav hauv cov hlab ntsha, kev mob plawv, ntshav tawm, thiab lwm yam.

Ob yam tshuaj yuav tsum tau siv nyob rau hauv cov teebmeem hauv qab no:

Kom cov ntshav roj tag nrho,
Kom siab ntau ntawm LDL, VLDL, triglycerides,
Kab mob rau lub plawv (tsis muaj ntshav txaus rau cov leeg plawv) thiab txhua qhov kev tshwm sim (mob plawv, mob hlab plawv),
Atherosclerosis ntawm aorta, txog ntsha ntawm qis qis kawg ntawm lub paj hlwb, mob rau cov hlab ntsha hauv plab,
Nrog rau ntshav siab - txhawm rau tiv thaiv kev txhim kho ntawm atherosclerosis.

Cov Yuav Tsum Muaj

Atorvastatin siv tsis tau rau:

Intolerance rau cov tshuaj,
Mob mob siab,
Daim siab ua haujlwm tsis zoo,
Cev xeeb tub thiab lactation.

Intolerance rau cov tshuaj,
Mob mob siab,
Daim siab ua haujlwm tsis zoo,
Kev mob raum tsis zoo,
Cov pob txha leeg pob txha puas,
Noj cyclosporine,
Cev xeeb tub thiab lactation
Lub hnub nyoog txog 18 xyoo.

Sab sij huam

Atorvastatin tuaj yeem ua rau:

Mob taub Hau
Neeg tsis muaj zog
Insomnia
Kev mob hauv siab
Daim siab ua haujlwm tsis zoo,
Kev o ntawm cov kabmob ENT,
Lub plab zom zaws,
Mob thiab pob txha mob
O o
Kev ua xua tsis haum.

Phiv los ntawm rosuvastatin:

Kev txhim kho mob ntshav qab zib mellitus (carbohydrate metabolism tsis meej),
Mob taub hau
Lub plab zom zaws,
Daim siab ua haujlwm tsis zoo,
Mob leeg
Neeg tsis muaj zog.

Tso daim ntawv thiab nqi

Tus nqi ntawm Atorvastatin ntsiav tshuaj sib txawv heev raws li cov khw:

10 mg, 30 pcs. - 130 - 260 p,
10 mg, 60 pcs. - 300 r
10 mg, 90 pcs. - 550 - 710 r,
20 mg, 30 pcs. - 165 - 420 r,
20 mg, 90 pcs. - 780 - 1030 r,
40 mg, 30 pcs. - 295 - 630 p.

Tus nqi ntawm rosuvastatin ntsiav tshuaj kuj txawv txav:

5 mg, 28 pcs. - 1970 p
5 mg, 30 pcs. - 190 - 530 r,
5 mg, 90 pcs. - 775 - 1020 r,
5 mg, 98 pcs. - 5620 r,
10 mg, 28 pcs. - 420 - 1550 r,
10 mg, 30 pcs. - 310 - 650 p,
10 mg, 60 pcs. - 620 r
10 mg, 90 pcs. - 790 - 1480 r,
10 mg, 98 pcs. - 4400 r
10 mg, 126 pcs. - 5360 r,
15 mg, 30 pcs. - 600 r
15 mg, 90 pcs. - 1320 r,
20 mg, 28 pcs. - 505 - 4050 r,
20 mg, 30 pcs. - 400 - 920 p,
20 mg, 60 pcs. - 270 - 740 r,
20 mg, 90 pcs. - 910 - 2170 r,
40 mg, 28 pcs. - 5880 r,
40 mg, 30 pcs. - 745 - 1670 r,
40 mg, 90 pcs. - 2410 - 2880 p.

Rosuvastatin lossis Atorvastatin - uas zoo dua?

Yog tias koj xaiv qhov tshuaj twg zoo dua purely los ntawm kev pom ntawm cov kws kho mob, thaum ntawd nws yuav yog Rosuvastatin. Txij li nws tuaj yeem noj nyob hauv qis dua, ntau npaum li cas thiab nws cov kev mob tshwm sim tsawg dua li ntawm Atorvastatin. Txawm li cas los xij, nws kim heev, tshwj xeeb tshaj yog tsim los ntawm lub tuam txhab Teva lossis Astrazenek (Krestor). Siv tshuaj ib hlis ib zaug, uas yuav noj ntau npaum li cas ua tau zoo rau qee cov neeg mob tsuas yog yooj yim. Hauv qhov no, atorvastatin tseem yog cov khoom siv feem ntau siv.

Qhov twg yog qhov zoo dua: atorvastatin lossis rosuvastatin? Xyuas

Kuv muaj cov roj ntshav siab ntau, kuv txiv tuag ntawm lub plawv nres yuav luag muaj hnub nyoog 40 xyoo. Kuv tau haus Atorvastatin ntev heev, kuv twb yuav luag 40 thiab kuv yuav tsis tau tuag tseem, thiab cov hlab tau tsis zoo heev, tab sis tseem tuaj yeem tiv taus,
Kuv tsis tuaj yeem haus cov tshuaj no - tam sim ntawd lub siab pib tsis zoo, tsis muaj zog,
Ib qho tshuaj txawv heev. Cov txiaj ntsig ntawm nws tsis xav, tab sis txhua tus kws kho mob yuam nws coj. Tab sis kev ntsuam xyuas tau zoo tom qab nws.

Kuv tsuas yog tsis tuaj yeem siv cov nyiaj ntawd txhua hli, txawm tias kuv nyiam. Thiab kuv sawv tsis tau Atorvastatin,
Cov kev hloov zoo rau atorvastatin: txo tshuaj, zoo dua lub zog,
Kuv tsis nkag siab tias yog vim li cas thiaj them cov nyiaj vwm no yog tias koj tuaj yeem haus qhov pheej yig dua.

Dab tsi yog statins?

Statins suav nrog cov pab pawg coob coob ntawm cov tshuaj siv kom txo qis ntawm LDL thiab VLDL hauv cov ntshav.

Hauv kev kho mob niaj hnub, cov tshuaj statins tsis tuaj yeem muaj kev tiv thaiv thiab kev kho mob ntawm atherosclerosis, hypercholisterinemia (kev sib xyaw lossis homozygous), nrog rau cov kab mob plawv.

Feem ntau, cov tshuaj ntawm cov pab pawg no muaj tib txoj kev kho mob, i.e. qis dua LDL thiab VLDL qib. Txawm li cas los xij, vim muaj ntau yam kev ua haujlwm thiab cov koom haum pabcuam, muaj qee qhov sib txawv uas yuav tsum tau muab coj los txiav txim txhawm rau zam kom tsis txhob muaj qhov tsis zoo.

Statins feem ntau muab faib ua I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) thiab IV tiam (Pitavastatin, Rosuvastatin).

Statins tuaj yeem yog cov khoom ntuj thiab hluavtaws. Rau cov kws tshaj lij, xaiv cov khoom lag luam qis-nruab nrab, lossis siab rau cov neeg mob yog qhov tseem ceeb.

Rosuvastatin thiab Atorvastatin feem ntau siv los txo cov roj (cholesterol). Txhua yam ntawm cov tshuaj muaj cov yam ntxwv:

Rosuvastatin hais txog statins ntawm plaub tiam. Tus lipid-txo tus neeg sawv cev yog tag nrho hluavtaws nrog qhov nruab nrab qhov ntau ntawm cov khoom siv nquag. Nws yog tsim nyob rau hauv ntau cov cim lag luam, piv txwv li, Krestor, Mertenil, Rosucard, Rosart, thiab lwm yam.

Atorvastatin belongs rau III tiam statins. Zoo li nws cov analogue, nws muaj keeb kwm hluavtaws, tab sis muaj qhov siab ntawm cov tshuaj nquag.

Muaj cov lus txhais ntau ntawm cov tshuaj xws li Atoris, Liprimar, Toovacard, Vazator, thiab lwm yam.

Tshuaj lom neeg muaj pes tsawg leeg ntawm cov tshuaj

Ob qho tshuaj no muaj nyob hauv daim foos. Rosuvastatin yog tsim nyob rau hauv ntau qhov kev siv tshuaj - 5, 10 thiab 20 mg ntawm tib cov tshuaj tivthaiv. Atorvastatin tawm hauv kev noj tshuaj ntawm 10,20,40 thiab 80 mg ntawm cov tshuaj xyaw nquag. Hauv qab no yog cov lus piv piv ua ntu pab cuam ntawm ob tus neeg sawv cev zoo ntawm statins.

Rosuvastatin	Txoj Kev Noj Qab Haus Huv (Atorvastatin)
Hypromellose, hmoov txhuv nplej siab, titanium dioxide, crospovidone, microcrystalline cellulose, triacetin, magnesium stearate, silicon dioxide, titanium dioxide, carmine zas.	Lactose monohydrate, croscarmellose sodium, titanium dioxide, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, microcrystalline cellulose,

Lub ntsiab sib txawv ntawm Rosuvastatin thiab Atorvastatin yog lawv lub cev ua haujlwm ntawm lub cev. Qhov zoo ntawm rosuvastatin yog tias nws tau yooj yim tawg hauv cov ntshav ntshav thiab lwm yam kua, i.e. yog hydrophilic. Atorvastatin muaj lwm qhov ntxiv: nws yog soluble hauv cov rog, i.e. yog lipophilic.

Raws li cov cwj pwm no, cov nyhuv ntawm Rosuvastatin yog feem ntau qhia rau lub hlwb ntawm daim siab parenchyma, thiab Atorvastatin - rau cov qauv ntawm lub hlwb.

Pharmacokinetics thiab pharmacodynamics - sib txawv

Twb tau nyob rau theem ntawm kev noj cov ntsiav tshuaj, muaj qhov sib txawv hauv lawv qhov kev nqus. Yog li, kev siv rosuvastatin tsis nyob ntawm seb lub sijhawm nruab hnub lossis noj mov. Atorvastatin yuav tsum tsis txhob noj ib txhij nrog zaub mov noj, li qhov no cuam tshuam tsis zoo rau kev nqus ntawm cov nquag tivthaiv. Cov ntsiab lus ntau ntawm Atorvastatin yog ua tiav tom qab 1-2 teev, thiab Rosuvastatin - tom qab 5 teev.

Lwm qhov txawv ntawm statins yog lawv cov metabolism. Hauv tib neeg lub cev, Atorvastatin tau hloov pauv mus ua ib qho kev tsis txaus ntseeg siv daim siab ua haujlwm ntawm lub siab. Yog li, cov haujlwm ntawm cov tshuaj yog cuam tshuam ncaj qha rau kev ua haujlwm ntawm lub siab.

Nws kuj tseem cuam tshuam los ntawm cov tshuaj uas tau siv ib txhij nrog Atorvastatin. Nws cov tshuaj analogue, ntawm qhov tsis sib xws, vim tias muab tshuaj rau qis dua, kev coj ua tsis cuam tshuam nrog lwm cov tshuaj. Txawm hais tias qhov no tsis cawm nws los ntawm qhov muaj qhov tshwm sim tsis zoo.

Atorvastatin feem ntau mob cov kua tsib.

Tsis zoo li ntau yam statins, Rosuvastatin yuav luag tsis txaus nyob rau hauv daim siab: ntau dua 90% ntawm cov tshuaj raug tshem tawm tsis hloov pauv los ntawm txoj hnyuv thiab tsuas yog 5-10% los ntawm lub raum.

Qhov Kev Nkag Siab Thiab Cov Neeg Siv Khoom Tso Tawm

Lub luag haujlwm tseem ceeb ntawm cov tshuaj statin yog txhawm rau txo qis ntawm LDL hauv cov ntshav thiab nce qib HDL.

Yog li, xaiv ntawm Atorvastatin thiab Rosuvastatin, peb yuav tsum piv qhov zoo lawv txo qis cov roj (cholesterol).

Ib txoj kev tshawb fawb tsis ntev los no tau ua pov thawj tias rosuvastatin yog ib hom tshuaj uas ua tau zoo dua.

Cov chaw soj ntsuam kuaj mob raug nthuav tawm hauv qab no:

Nrog kev sib luag ntawm cov tshuaj, Rosuvastatin txo LDL roj los ntawm 10% zoo dua li nws cov tshuaj tiv thaiv. Qhov txiaj ntsig zoo no tso cai rau kev siv cov tshuaj rau cov neeg mob uas muaj mob hypercholesterolemia.
Qhov nquag ntawm txoj kev loj hlob ntawm cov hlab plawv cov teeb meem thiab qhov pib ntawm lub txiaj ntsig tuag yuav ua rau siab dua hauv Atorvastatin.
Qhov tshwm sim ntawm kev phiv tshuaj yog tib yam rau ob qho tshuaj.

Kev sib piv ntawm cov txiaj ntsig ntawm kev txo qis ntawm cov "phem" cov roj (cholesterol) tau ua pov thawj qhov tseeb tias Rosuvastatin yog ib qho tshuaj zoo dua. Txawm li cas los xij, ib qho yuav tsum tsis txhob hnov qab txog cov xwm txheej zoo li no muaj qhov sib txuam ntawm contraindications, phiv thiab nqi. Ib qho kev sib piv ntawm tus nqi ntawm ob cov tshuaj tau nthuav tawm hauv lub rooj.

Tsuas tshuaj, cov naj npawb ntawm cov ntsiav tshuaj	Rosuvastatin	Atorvastatin
5mg Tsis Yog 30	335 RUB	—
10mg Tsis Yog 30	360 rubles	125 rub
20mg Tsis Yog 30	485 rub	150 rub
40mg No. 30	—	245 RUB
80mg No. 30	—	490 rub

Yog li, atorvastatin yog qhov pheej yig dua uas cov neeg tau nyiaj tsawg yuav them taus.

Qhov ntawd yog qhov uas cov neeg mob xav txog tshuaj - Rosuvastatin muaj kev tiv thaiv zoo thiab tsis muaj teeb meem. Thaum nws noj, roj (cholesterol) phem yuav txo tau

Kev sib piv ntawm cov tshuaj pab txhawm rau txiav txim siab tias tam sim no theem ntawm txoj kev loj hlob ntawm cov tshuaj, thawj txoj haujlwm ntawm cov ntsiav tshuaj roj zoo tshaj plaws yog nyob ntawm cov statins ntawm plaub tiam, suav nrog Rosuvastatin.

Hais txog cov tshuaj Rosuvastatin thiab nws cov analogues tau piav qhia hauv video hauv kab lus no.