Augmentin 125 ntsiav tshuaj: cov lus qhia rau kev siv

Coated ntsiav tshuaj, 500 mg / 125 mg thiab 875 mg / 125 mg

Ib ntsiav tshuaj muaj

yam tshuaj: amoxicillin (li amoxicillin trihydrate) 500 mg lossis 875 mg,

clavulanic acid (li poov tshuaj clavulanate) 125 mg,

tus zam: magnesium stearate, sodium hmoov txhuv nplej glycolate hom A, silicon dioxide colloidal anhydrous, microcrystalline cellulose,

plhaub muaj pes tsawg leeg: titanium dioxide (E 171), hypromellose (5 cps), hypromellose (15 cps), macrogol 4000, macrogol 6000, roj silicone (dimethicone 500).

500 mg / 125 mg ntsiav tshuaj

Cov ntsiav tshuaj coated yog oval los ntawm dawb mus dawb hauv cov xim, txho nrog "A C" thiab nqis siab rau ntawm ib sab thiab du ntawm lwm sab.

Ntsiav tshuaj 875 mg / 125 mg

Cov ntsiav tshuaj uas pleev tau yog lub qe dawb los ntawm xim dawb los dawb, nrog kev thaiv ntawm ib sab thiab tus “A C” uas dai rau ob sab ntawm lub ntsiav tshuaj.

Cov chaw muag tshuaj

Farmakokinetics

Amoxicillin thiab clavulanate yaj tau zoo nyob rau hauv kev daws teeb meem nrog lub cev pH, ob qho tshuaj tau sai thiab tag nrho los ntawm lub plab zom mov tom qab kev tswj hwm qhov ncauj. Kev nqus ntawm amoxicillin thiab clavulanic acid yog qhov zoo dua thaum noj cov tshuaj thaum pib noj mov. Tom qab noj cov tshuaj hauv, nws txoj kev noj qab haus huv yog 70%. Cov xaib ntawm ob qho tshuaj ntawm cov tshuaj no zoo sib xws thiab mus txog qhov siab tshaj plaws ntshav plasma concentration (Tmax) hauv thaj tsam li 1 teev. Qhov kev sib xyaw ntawm amoxicillin thiab clavulanic acid hauv cov ntshav cov ntshav yog tib yam ob qho tib si kev sib xyaw ua ke ntawm kev siv amoxicillin thiab clavulanic acid, thiab txhua feem sib xyaw.

Kev khi ntawm amoxicillin thiab clavulanic acid rau ntshav cov ntshav yog muaj ntsis: 25% rau clavulanic acid thiab 18% rau amoxicillin. Cov pom tseeb ntawm kev faib tawm yog kwv yees li 0.3-0.4 l / kg rau amoxicillin thiab txog 0.2 l / kg rau clavulanic acid.

Tom qab kev tswj hwm iv, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid tau ua tiav hauv cov kabmob thiab cov nqaij sib txawv, cov kua dej ua haujlwm (mob ntsws, plab hnyuv plab, lub zais zis, adipose, pob txha thiab cov leeg nqaij, pleural, synovial thiab peritoneal kua, tawv nqaij, bile, purulent tawm) hnoos qeev). Kev siv Amoxicillin thiab clavulanic acid tsis nkag mus rau hauv cov kua dej ua kua hlwb.

Amoxicillin, zoo li feem ntau rau penicillins, raug tawm hauv niam cov kua mis. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam cov kua mis. Txhawm rau kev zam ntawm kev pheej hmoo ntawm kev hnov ​​mob, amoxicillin thiab clavulanic acid tsis cuam tshuam loj rau kev noj qab haus huv ntawm cov menyuam mos uas pub niam mis. Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav.

Amoxicillin yog qee cov tso tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog penicillinic acid nyob rau hauv ib qho nyiaj npaum li 10-25% ntawm cov koob tshuaj. Clavulanic acid nyob rau hauv lub cev yauv nkag mus rau cov metabolism hauv plab ntau dua thiab ua rau cov zis thiab quav, ntxiv rau hauv cov pa roj carbon dioxide los ntawm kev ua pa.

Amoxicillin tsuas yog tawm hauv lub raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab. Tom qab cov tshuaj noj ib qhov ncauj ntawm ib ntsiav tshuaj ntawm 250 mg / 125 mg los sis 500 mg / 125 mg, kwv yees li 60-70% ntawm amoxicillin thiab 40-65% ntawm clavulanic acid raug tshem tawm tsis hloov pauv hauv cov zis thaum thawj 6 teev.

Ntau cov kev tshawb fawb tau paub tseeb tias kev tso zis tawm yog 50-85% rau amoxicillin thiab 27-60% rau clavulanic acid hauv 24 teev. Rau cov clavulanic acid, qhov ntau tshaj plaws tau tawm hauv thawj 2 teev tom qab kev tswj hwm.

Kev siv concomitant ntawm probenecid ua rau qeeb lub raum tsis zoo ntawm amoxicillin, tab sis tsis qeeb cov tshuaj clavulanic acid nrog lub raum.

Cov Tshuaj Hauv Tshuaj

Augmentin® yog cov tshuaj tua kab mob sib xyaw ua ke uas muaj amoxicillin thiab clavulanic acid, nrog rau kev pom dav ntawm cov kab mob hauv lub cev, tiv taus beta-lactamase.

Amoxicillin Yog cov tshuaj tua kab mob ib nrab ntawm cov tshuaj tua kab mob (beta-lactam), qhov kev pom ntawm kev ua, dav tawm tsam ntau cov kab mob gram-positive thiab gram-tsis zoo.

Cov kab mob bactericidal ntawm kev txiav txim ntawm amoxicillin yog rau inhibit biosynthesis ntawm peptidoglycans ntawm cov kab mob ntawm phab ntsa, uas ua rau lub lysis thiab kev tuag ntawm cov kab mob hauv lub cev.

Amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamase uas ua los ntawm cov kab mob tiv taus, thiab yog li ntawd kev ua si spectrum ntawm amoxicillin ib leeg tsis suav nrog cov kab mob me me uas ua cov enzymes no.

Clavulanic acid - Qhov no yog beta-lactamate, zoo ib yam li hauv tshuaj qauv rau penicillins, uas muaj peev xwm ua kom tsis muaj zog ntawm beta-lactamase enzymes ntawm cov kab mob me me uas tawm tsam penicillins thiab cephalosporins, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin. Beta-lactamases yog ua los ntawm ntau cov kab mob gram-positive thiab gram-tsis zoo. Clavulanic acid thaiv qhov kev txiav txim ntawm cov enzymes, rov kho qhov rhiab ntawm cov kab mob mus rau amoxicillin. Hauv tshwj xeeb, nws muaj cov haujlwm siab tiv thaiv plasmid beta-lactamases, uas cov tshuaj tiv thaiv feem ntau cuam tshuam, tab sis tsis muaj txiaj ntsig tawm tsam hom 1 chromosomal beta-lactamases.

Muaj cov clavulanic acid nyob rau hauv Augmentin® tiv thaiv amoxicillin los ntawm kev puas tsuaj ntawm beta-lactamases thiab nthuav nws lub zog ntawm kev ua haujlwm tiv thaiv kab mob nrog rau kev suav nrog cov kab mob me me uas feem ntau tiv taus lwm yam penicillins thiab cephalosporins. Clavulanic acid nyob rau hauv daim ntawv ntawm ib qho tshuaj tsis muaj qhov ua kev sib deev muaj txiaj ntsig kev kho mob.

Txhim kho txoj kev tawm tsam

Nws muaj 2 lub txheej txheem rau kev txhim kho ntawm kev ua haujlwm rau Augmentin®:

- kev tsis ua haujlwm los ntawm cov kab mob beta-lactamases, uas tsis raug rau qhov cuam tshuam ntawm clavulanic acid, suav nrog cov chav kawm B, C, D

- deformation ntawm penicillin-khi protein, uas ua rau kom txo qis ntawm qhov xwm txheej ntawm cov tshuaj tua kab mob cuam tshuam nrog cov kab mob me

Lub zog tsis zoo ntawm cov kab mob phab ntsa, nrog rau cov txheej txheem ntawm lub twj tso kua mis, tuaj yeem ua rau los yog pab txhawb kev txhim kho ntawm kev tawm tsam, tshwj xeeb tshaj yog cov kab mob gram-tsis zoo.

Augmentin®muaj cov nyhuv bactericidal ntawm cov kab mob hauv qab no:

Gram-zoo aerobes: Bacillius anthracis,Enterococcus faecalis,Gardnerella vaginalis,Listeria monocytogenes, Nocardia cov hnub qub,Dab Tsi Staphylococcus aureus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin), Tus kab mob Streptococcus agalactiae,Kab mob ntsws dej liab1,Cov kab mob Streptococcus pyogenes thiab lwm yam beta hemolytic streptococci, pab pawg Streptococcus viridans,

Gram-negative aerobes: Actinobacillusactinomycetemcomitans,Capnocytophagaspp.,Eikenellacorrodens,Haemophilusmob khaub thuas,Moraxellacatarrhalis,Neisseriagonorrhoeae,Pasteurellamultocida

anaerobic microorganisms: Bacteroides fragilis,Fusobacterium nucleatum,Prevotellaspp.

Cov kab mob uas muaj qhov ua tau kom tiv taus

Gram-zoo aerobes: Enterococcusfaecium*

Cov kab mob nrog lub ntuj tsis kam:

gram tsis zooaerobes:Acinetobacterhom,Citrobacterfreundii,Enterobacterhom,Legionella pneumophila, Morganella morganii, Providenciahom, Pseudomonashom, Serratiahom, Stenotrophomonas maltophilia,

lwm yam: Chlamydia trachomatis,Chlamydophila mob ntsws, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

1 Tsis suav hom Kab mob ntsws dej liabpenicillin tiv taus

* Lub cev rhiab heev nyob rau hauv qhov tsis muaj kis tau ua hauj

Kev ntsuas rau siv

- mob kab mob siab (nrog paub tseeb hais tias yog mob)

- mob o ntawm pob ntseg hauv nruab nrab (mob otitis media)

- exacerbation ntawm mob ntsws (nrog paub tseeb tias mob)

- mob txeeb zig (cystitis, pyelonephritis)

- kis mob ntawm daim tawv nqaij thiab cov nqaij mos (tshwj xeeb, cellulite, tsiaj tom, muaj mob voos thiab phlegmon ntawm thaj chaw maxillofacial)

- kis mob ntawm cov pob txha thiab pob qij txha (tshwj xeeb, osteomyelitis)

Cov lus tshaj tawm cov tswv yim rau kev siv tsim nyog ntawm cov tshuaj tiv thaiv kab mob yuav tsum tau siv rau hauv qhov tseeb.

Tsuas tshuaj thiab tswj hwm

Qhov rhiab siab rau Augmentin® yuav txawv raws qhov chaw thiab lub sijhawm. Ua ntej sau tshuaj, yog tias ua tau nws yuav tsum tau los ntsuas qhov rhiab ntawm cov kab mob raws li cov ntaub ntawv hauv zos thiab txiav txim siab qhov rhiab siab los ntawm kev kuaj thiab ntsuas cov qauv los ntawm tus neeg mob tshwj xeeb, tshwj xeeb yog kis mob hnyav.

Augmentin® tuaj yeem siv los kho cov mob los ntawm amoxicillin-rhiab microorganisms, thiab sib xyaw sib kis mob los ntawm amoxicillin-thiab clavulanate-rhiab cov leeg tsim beta-lactamase.

Cov tshuaj muab rau noj yog teem raws li lub hnub nyoog, lub cev nyhav, lub raum kev ua haujlwm, kev kis tus kab mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom txo qis kev pheej hmoo ntawm cuam tshuam rau lub plab hnyuv, Augmentin® pom zoo kom noj nrog zaub mov thaum pib noj mov rau qhov nqus ntau. Lub sijhawm kho yog nyob ntawm tus neeg mob cov lus teb rau kev kho mob. Qee cov kab mob pathologies (tshwj xeeb, osteomyelitis) yuav xav tau kev kawm ntev dua. Txoj kev kho yuav tsum tsis txhob txuas ntxiv rau 14 hnub yam tsis rov ntsuas nws tus mob. Yog tias tsim nyog, nws yog qhov ua tau los ua cov kauj ruam kev kho mob (thawj zaug, kev tswj hwm cov tshuaj nrog kev hloov pauv tom qab kev tswj hwm hauv qhov ncauj).

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg

Me me mus rau mob mentsis mus txog rau mob mentsis (cov qauv uas siv)

1 ntsiav tshuaj 500 mg / 125 mg 2-3 zaug ib hnub lossis 1 ntsiav tshuaj 875 mg / 125 mg 2 zaug ib hnub

Kev kis mob hnyav (mob otitis media, sinusitis, mob ntsws qis, mob txeeb zig)

1-2 ntsiav tshuaj 500 mg / 125 mg 3 zaug ib hnub lossis 1 ntsiav tshuaj 875 mg / 125 mg 2 lossis 3 zaug ib hnub

Qhov koob tshuaj ntau tshaj plaws rau cov laus thiab cov menyuam hnub nyoog 12 xyoos uas siv cov ntsiav tshuaj ntau npaum li 500 mg / 125 mg yog 1500 mg ntawm amoxicillin / 375 mg ntawm clavulanic acid. Rau cov tshuaj noj nrog qhov ntau npaum 875 mg / 125 mg, qhov siab tshaj plaws txhua hnub yog 1750 mg ntawm amoxicillin / 250 mg ntawm clavulanic acid (thaum noj 2 zaug hauv ib hnub) lossis 2625 mg ntawm amoxicillin / 375 mg ntawm clavulanic acid (thaum noj 3 zaug hauv ib hnub).

Cov me nyuam qis dua 12 xyoos los hnyav dua 40 kg

Daim ntawv tsuas noj no tsis yog npaj rau cov menyuam hnub nyoog qis dua 12 xyoos lossis cov menyuam yaus uas hnyav dua 40 kg. Cov menyuam yaus no tau muab Augmentin® los ua qhov raug tshem tawm rau txoj kev tswj hwm qhov ncauj.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov koob tshuaj yog ua raws li qhov siab tshaj plaws pom zoo muab koob tshuaj amoxicillin thiab creatinine tshem tawm tus nqi.

Augmentin ntau npaum tshuaj®

Tsis tas yuav txhaj koob tshuaj

1 ntsiav tshuaj 500 mg / 125 mg 2 zaug ib hnub

30 ml / min. Cov neeg mob Hemodialysis

Kev hloov pauv koob yog nce raws li qhov xav tau ntau tshaj ntawm amoxicillin.

Cov Neeg Laus: 1 ntsiav tshuaj 500 mg / 125 mg txhua 24 teev Yeem 1 koob tau muab tshuaj rau lub sijhawm lim ntshav thiab lwm koob tshuaj nyob rau thaum xaus ntawm kev lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm 875 mg / 125 mg yuav tsum tsuas yog siv rau hauv cov neeg mob uas muaj kev tshem tawm creatinine> 30 ml / min. Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua.

Txo Augmentin Koob Tshuaj® tsis tsim nyog, cov koob tshuaj yog tib yam rau cov neeg laus. Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau kho raws li tau piav qhia saum toj no rau cov neeg laus uas lub raum tsis ua haujlwm.

Sab sij huam

Cov kev phiv tshuaj pom nyob rau hauv kev soj ntsuam kuaj mob thiab hauv lub sijhawm ua lag luam tom qab tau hais hauv qab no thiab tau teev tseg nyob ntawm qhov paub ntawm lub cev thiab lub cev kev faib tawm thiab ntau zaus uas tshwm sim.

Qhov ntau zaus ntawm qhov tshwm sim tau txiav txim siab raws li hauv qab no: heev heev (≥1/10), feem ntau (≥1 / 100 thiab

Daim ntawv tso tawm

Cov tshuaj muaj daim ntawv tso tawm hauv qab no:

• Augmentin ntsiav tshuaj 250 mg + 125 mg, Augmentin 500 mg + 125 mg thiab Augmentin 875 + 125 mg.
• Hmoov 500/100 mg thiab 1000/200 mg, npaj rau kev npaj ntawm kev daws rau kev txhaj tshuaj.
• Hmoov rau kev ncua ncua Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• Hmoov Augmentin EU 600 mg / 42.9 mg (5 ml) rau kev ncua.
• Augmentin CP 1000 mg / 62.5 mg txhawb cov ntsiav tshuaj tso tawm

Pharmacodynamics thiab pharmacokinetics

Raws li Wikipedia, Amoxicillin yog cov kab mob bactericidalzoo tiv thaiv ntau yam kab mob thiab cov kab mob muaj peev xwm cov kab mob me me thiab sawv cev semisynthetic penicillin pawg tshuaj tiv thaiv.

Txhawb pab transpeptidase thiab cuam tshuam nrog kev tsim khoom mureina (qhov tseem ceeb tshaj plaws ntawm cov phab ntsa ntawm cov kab mob hauv lub cev) thaum lub sijhawm faib thiab kev loj hlob, nws provokes li lysis (kev rhuav tshem) cov kab mob.

Amoxicillin raug rhuav tshem -lactamasesyog li nws cov kev ua haujlwm tiv thaiv kab mob tsis txuas ntxiv cov kab mob me metsim khoom -lactamases.

Ua raws li kev sib tw thiab nyob rau hauv feem ntau ntawm ib tug tsis tuaj yeem inhibitor, clavulanic acid tsiag ntawv los ntawm kev muaj peev xwm txeem ntxeem phab ntsa cov kab mob thiab ua rau inactivation cov enzymesuas muaj nyob ntawm ob sab ntawm tes thiab ntawm nws cov ciam teb.

Clavulanate cov ntaub ntawv ruaj khov inactivated complexes nrog -lactamasesthiab no nyeg tiv thaiv kev puas tsuaj amoxicillin.

Augmentin tshuaj tua kab mob zoo tiv thaiv:

• Nyiaj Gram (+) aerobes: pyogenic mob streptococcus pawg A thiab B, pneumococci, Staphylococcus aureus thiab mob sab nrauv, (tshwj tsis yog zam ntawm kab mob methicillin-tiv taus lim tawm), saprophytic staphylococcus thiab lwm tus
• Nyiaj Gram (-) aerobes: Pfeiffer nrog, mob hnoos hawb pob, gardnerella vaginalis , Mob raws plab lwm yam.
• Gram (+) thiab Gram (-) ntawm anaerobes: bacteroids, fusobacteria, preotellaslwm yam.
• Lwm yam kab mob me me: mob chlamydia, spirochete, daj ntseg treponema lwm yam.

Tom qab kev siv cov tshuaj Augmentin, ob qho ntawm nws lub cev ua kom nrawm nrawm thiab nqus tawm ntawm qhov hnyuv. Kev nqus tau yog qhov zoo dua yog tias ntsiav tshuaj lossis kua dej cawv thaum noj mov (thaum pib noj mov).

Ob qho tib si thaum noj ntawm qhov ncauj, thiab nrog cov lus qhia ntawm Augmentin IV kev daws teeb meem, kev kho tshuaj ntau ntawm cov tshuaj ua kom muaj zog nyob hauv txhua cov ntaub so ntswg thiab cov kua dej ua kua interstitial.

Ob leeg lub zog ua kom tsis muaj zog khi rau ntshav ntshav protein (txog 25% khi rau cov ntshav protein amoxicillin trihydratethiab tsis ntau tshaj 18% clavulanic acid) Tsis muaj qhov mus ntxiv ntawm Augmentin raug kuaj pom ib qho ntawm cov kabmob hauv nruab nrog.

Amoxicillin nphav raug kev zom mov nyob rau hauv lub cev thiab excreted ob lub raumlos ntawm kev zom cov pa zom zaws thiab hauv daim ntawv cov roj carbon dioxide nrog rau cov pa tawm kom zoo. 10 txog 25% ntawm qhov koob tau txaisamoxicillin raug zam ob lub raum hauv daim ntawv penicilloic aciduas yog nws tsis tsaug zog metabolite.

Clavulanate raug tawm ob leeg los ntawm lub raum thiab los ntawm txoj kev ua cov txheej txheem ntxiv.

Cov Yuav Tsum Muaj

Augmentin nyob rau hauv txhua daim ntawv qhia cov tshuaj yog contraindicated:

• cov neeg mob uas lub siab tsis haum rau ib lossis ob qho kev sib txuas ntawm cov tshuaj, rau ib qho ntawm nws qhov kev tshem tawm, ntxiv rau -lactam (i.e. to tshuaj tua kab mob los ntawm tej pab pawg tshuaj penicillin thiab cephalosporin),
• cov neeg mob uas tau ntsib kev kho mob ntawm Augmentin kho mob dajntoo lossis keeb kwm ntawm qhov tsis taus zoo mob siab vim kev siv tshuaj sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Ib qho kev tiv thaiv ntxiv rau kev teem caij ua hmoov rau kev npaj ntawm qhov ncauj tshem tawm nrog qhov ntau npaum ntawm cov tshuaj dej ntawm 125 + 31.25 mg yog PKU (phenylketonuria).

Lub hmoov siv rau kev npaj ntawm qhov ncauj ncua nrog qhov ntau npaum ntawm cov tshuaj dej (200 + 28.5) thiab (400 + 57) mg yog contraindicated:

• ntawm PKU,
• cov neeg mob uas tsis taus raumntawm qhov ntsuasReberg kev ntsuam xyuas hauv qab no 30 ml ib feeb
• cov menyuam yaus hnub nyoog qis dua 3 hlis.

Ib qho kev tiv thaiv ntxiv rau kev siv cov ntsiav tshuaj nrog cov tshuaj ntau dua (250 + 125) thiab (500 + 125) mg yog lub hnub nyoog qis dua 12 xyoos thiab / lossis hnyav dua 40 phaus.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov tshuaj nquag 875 + 125 mg yog contraindicated:

• ua txhaum txoj haujlwm kev ua haujlwm raum (ntsuas Reberg kev ntsuam xyuas hauv qab 30 ml ib feeb)
• cov me nyuam qis dua 12 xyoos
• cov neeg mob uas lub cev tsis hnyav tshaj 40 kg.

Cov lus qhia rau kev siv Augmentin: txoj kev thov, ntau npaum li cas rau cov neeg laus thiab menyuam yaus

Ib qho ntawm cov lus nug feem ntau ntawm tus neeg mob yog cov lus nug txog kev noj tshuaj ua ntej lossis tom qab noj mov. Nyob rau hauv rooj plaub ntawm Augmentin, kev noj tshuaj yog ze ze rau kev noj mov. Nws yog suav hais tias yog qhov zoo tshaj rau noj cov tshuaj ncaj qha. ua ntej noj mov.

Ua ntej, nws muab kev nqus zoo dua ntawm lawv cov tshuaj nquag Kev kho mob txoj hnyuv, thiab, ob, nws tuaj yeem txo qhov hnyav Mob plab zom mov tsis haum ntawm lub plab zom movyog tom kawg ntawv xwb.

Yuav ua li cas los xam cov koob tshuaj ntawm Augmentin

Yuav ua li cas noj cov tshuaj Augmentin rau cov neeg laus thiab menyuam yaus, nrog rau nws txoj kev kho kom haum, nyob ntawm seb qhov twg microorganism yog ib tug kab mob, kev rhiab npaum li cas yog nws raug tshuaj tua kab mob, qhov mob hnyav thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob, kev ua kom pom ntawm thaj chaw sib kis, lub hnub nyoog thiab qhov hnyav ntawm tus neeg mob, nrog rau nws noj qab haus huv npaum li cas ob lub raum tus neeg mob.

Lub sijhawm tiv thaiv ntawm cov chav kho yog nyob ntawm seb tus neeg mob lub cev teb li cas rau kev kho mob.

Augmentin ntsiav tshuaj: cov lus qhia rau kev siv

Ua raws li cov ntsiab lus ntawm cov tshuaj yeeb dej caw hauv lawv, Augmentin ntsiav tshuaj raug pom zoo rau cov neeg mob laus kom noj raws li cov qauv hauv qab no:

• Augmentin 375 mg (250 mg + 125 mg) - ib peb zaug ib hnub. Hauv kev siv ntau npaum li cas, cov tshuaj tau qhia rau kis tau tus mobuas ntws hauv yooj yim lossis tsim nyog me. Thaum muaj mob hnyav, suav nrog mob ntev thiab rov tshwm sim, ntau dua qhov tau muab tshuaj.
• Cov ntsiav tshuaj 625 mg (500 mg + 125 mg) - ib peb zaug ib hnub.
• 1000 mg ntsiav tshuaj (875 mg + 125 mg) - ib hnub ob zaug.

Qhov hno yog raug rau kev kho rau cov neeg mob uas tsis muaj lub luag haujlwm. raum.

Augmentin CP 1000 mg / 62.5 mg cia cov ntsiav tshuaj tso tawm tsuas yog pub rau cov neeg mob hnub nyoog 16 xyoo rov hauv. Cov koob tshuaj zoo yog ob ntsiav tshuaj ib hnub ob zaug.

Yog tias tus neeg mob tsis tuaj yeem nqos tag nrho cov ntsiav tshuaj, nws muab faib ua ob kab raws txoj kab txhaum. Ob qho tib si ob leeg tau coj tib lub sijhawm.

Cov neeg mob nrog rau cov neeg mob ob lub raum cov tshuaj yog kws kho tsuas yog hauv qhov xwm txheej ntawm qhov ntsuas Reberg kev ntsuam xyuas ntau tshaj 30 ml tauj ib feeb (uas yog, thaum kho kom haum rau qhov tshuaj ntau npaum li cas tsis tas yuav).

Hmoov rau cov tshuaj rau kev txhaj tshuaj: cov lus qhia rau kev siv

Raws li cov lus qhia, txoj kev daws teeb meem yog txhaj rau hauv txoj leeg: los ntawm dav hlau (qhov koob tshuaj yuav tsum tau txhaj tshuaj hauv 3-4 feeb) lossis los ntawm cov txheej txheem dej (lub sijhawm ntawm Txoj kev lis ntshav yog los ntawm ib nrab ntawm ib teev mus rau 40 feeb). Txoj kev daws tsis tau xav kom tau txhaj tshuaj rau hauv cov leeg.

Cov qauv muab rau ib tus neeg mob laus yog 1000 mg / 200 mg. Nws raug nquahu kom nkag nws txhua yim teev, thiab rau cov uas muaj teeb meem kis tau tus mob - txhua rau lossis rau plaub teev (raws li qhia).

Tshuaj tua kab mob hauv kev txiav txim siab ntawm tshuaj, 500 mg / 100 mg lossis 1000 mg / 200 mg yog tau sau tseg rau kev tiv thaiv kev txhim kho kis mob tom qab phais tasCov. Hauv kis uas lub sijhawm ua haujlwm tsawg dua li ib teev, nws txaus rau nkag mus rau tus neeg mob ib zaug ua ntej Tshuaj loog koob tshuaj ntawm Augmentin 1000 mg / 200 mg.

Yog tias nws cia siab tias qhov kev ua haujlwm yuav kav ntev dua li ib teev, txog plaub koob ntawm 1000 mg / 200 mg tau muab rau tus neeg mob nyob rau hnub dhau los rau 24 teev.

Kev ncua Augmentin: cov lus qhia rau kev siv

Cov lus qhia rau kev siv Augmentin rau menyuam yaus pom zoo kom teem sij hawm ncua ntawm 125 mg / 31.25 mg hauv koob tshuaj 2.5 txog 20 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 3 thaum nruab hnub. Qhov ntim ntawm ib koob tshuaj nyob ntawm lub hnub nyoog thiab qhov hnyav ntawm tus menyuam.

Yog tias tus menyuam loj dua ob lub hlis ntawm hnub nyoog, ncua kev ncua 200 mg / 28.5 mg yog tau sau rau hauv koob tshuaj ib yam li 25 / 3.6 mg rau 45 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav. Cov koob tshuaj uas tau hais tseg yuav tsum muab faib ua ob zaug.

Qhov ncua kev kawm ntawv nrog rau qhov ntau npaum ntawm cov tshuaj 400 mg / 57 mg (Augmentin 2) yog qhia rau kev siv pib txij li xyoo. Nyob ntawm seb tus me nyuam muaj hnub nyoog thiab hnyav li cas, ib koob tshuaj nws txawv ntawm 5 mus rau 10 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 2 thaum nruab hnub.

Augmentin EU yog pib txij 3 lub hlis hnub nyoog. Cov koob tshuaj zoo tshaj plaws yog 90 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub (qhov koob tshuaj yuav tsum tau muab faib ua 2 koob, khaws ib ntu 12-teev nruab nrab ntawm lawv).

Niaj hnub no, cov tshuaj hauv ntau hom tshuaj yog ib qho ntawm cov tshuaj tshaj plaws rau kev kho mob. mob qa.

Cov me nyuam Augmentin nrog mob caj pas sau rau hauv lub koob tshuaj uas tau txiav txim siab raws lub cev qhov hnyav thiab hnub nyoog ntawm tus menyuam. Nrog angina rau cov neeg laus, nws raug nquahu kom siv Augmentin 875 + 125 mg peb zaug ib hnub.

Tsis tas li, lawv feem ntau yog mus rau lub sijhawm Augmentin mob hlab ntswsCov. Txoj kev kho yog ntxiv los ntawm kev ntxuav lub qhov ntswg nrog ntsev hiav txwv thiab siv tshuaj txau qhov ntswg ntawm hom RinofluimucilCov. Koob tshuaj zoo rau mob hlab ntsws: 875/125 mg 2 zaug ib hnub. Lub sijhawm ua haujlwm ntawm feem ntau yog 7 hnub.

Noj ntau dhau

Tshaj dhau qhov koob ntawm Augmentin tau nrog los ntawm:

• kev txhim kho ntawm kev ua txhaum los ntawm cov hnyuv,
• ua txhaum ntawm dej-ntsev tshuav,
• crystalluria,
• lub raum tsis ua hauj lwm,
• nag lossis daus (nag lossis daus) ntawm amoxicillin nyob rau hauv lub raj tso zis.

Thaum cov tsos mob zoo li no tshwm sim, tus neeg mob tau qhia pom muaj kev kho mob, nrog rau, ntawm lwm yam, kev kho ntawm cov dej-ntsev kom sib npaug. Thim ntawm Augmentin los ntawm rauequilibrium system kuj pab txhawb tus txheej txheem hemodialysis.

Kev sib txuam

• pab txo kom tsawg tubular zais cia ntawm amoxicillin,
• provokes ib qho kev nce nyob rau hauv concentration amoxicillin hauv ntshav ntshav (cov nyhuv cuam tshuam ntev mus),
• tsis cuam tshuam rau cov khoom thiab theem ntawm cov ntsiab lus hauv clavulanic acid ntshav ntshav.

Sib txuam ua ke amoxicillin nrog allopurinol nce txoj kev nyiam qhov zuj zus ua xuaCov. Cov ntaub ntawv sib cuam tshuam allopurinol ib txhij nrog ob qho kev nquag ntawm Augmentan tsis tuaj.

Augmentin muaj cov nyhuv hauv uas muaj nyob hauv txoj hnyuv microflorauas provokes ib tug txo nyob rau hauv reabsorption (thim rov qab haum) tshuaj estrogen, nrog rau kev txo qis hauv cov txiaj ntsig ntawm kev sib xyaw ua ke tshuaj tiv thaiv rau kev siv qhov ncauj.

Cov tshuaj tsis sib xws nrog cov ntshav cov ntshav thiab cov kua-muaj kua, nrog rau suav nrog whey protein hydrolysates thiab roj emulsions npaj rau kev ntxig rau hauv cov leeg ntshav.

Yog tias Augmentin tawm tshuaj nrog rau tshuaj tua kab mob chav kawm aminoglycosides, cov tshuaj tsis sib xyaw rau hauv ib lub koob txhaj tshuaj lossis lwm lub thauv tshuaj ua ntej kev tswj hwm, vim tias qhov no ua rau tsis muaj zog aminoglycosides.

Cov Lus Qhia Txog Augmentin

Augmentin analogs yog cov tshuajA-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Txhua ntawm cov tshuaj saum toj no yog dab tsi Augmentin tuaj yeem hloov pauv hauv nws qhov tsis tuaj.

Tus nqi ntawm cov khoom tsis txawv txav los ntawm 63.65 txog 333.97 UAH.

Augmentin rau menyuam yaus

Augmentin siv dav hauv kev xyaum tsiaj txhu. Vim qhov tseeb tias nws muaj menyuam yaus daim ntawv tso tawm - kua phoov, nws tuaj yeem siv tau los kho menyuam yaus rau ib xyoos xwb. Kev teeb tsa tshwj xeeb ua rau txais tos thiab qhov tseeb hais tias cov tshuaj muaj cov khoom qab ntxiag.

Rau menyuam tshuaj tua kab mobfeem ntau kho mob rau mob caj pasCov. Qhov ntau npaum li cas ntawm kev ncua rau cov me nyuam yog txiav txim siab los ntawm lub hnub nyoog thiab qhov hnyav. Cov koob tshuaj zoo tshaj plaws tau muab faib ua ob koob, sib npaug 45 mg / kg ib hnub, lossis faib ua peb koob, koob tshuaj 40 mg / kg ib hnub.

Kev siv cov tshuaj rau cov menyuam yaus thiab caij nyoog ntau npaum li cas yog nyob ntawm daim ntawv ntau npaum li cas.

Rau cov menyuam yaus lub cev qhov hnyav tshaj 40 kg, Augmentin raug tso cai tib yam li cov neeg laus.

Augmentin phoov rau cov menyuam yaus txog li ib xyoos yog siv hauv qhov ntau ntawm 125 mg / 31.25 mg thiab 200 mg / 28.5 mg. Kev noj tshuaj ntawm 400 mg / 57 mg yog qhia rau cov menyuam yaus tshaj ib xyoos.

Cov menyuam yaus nyob rau hauv hnub nyoog 6-12 xyoo (hnyav dua 19 kg) raug tso cai siv ob qho kev ncua lossis Augmentin hauv cov ntsiav tshuaj. Kev muab tshuaj ntawm lub ntsiav tshuaj daim ntawv tshuaj yog raws li nram no:

• ib ntsiav tshuaj 250 mg + 125 mg peb zaug ib hnub,
• ib ntsiav tshuaj 500 + 125 mg ob zaug ib hnub (daim ntawv teev ntau npaum li no yog txoj kev pom zoo).

Cov menyuam yaus hnub nyoog dhau 12 xyoos raug samfwm kom noj ib ntsiav tshuaj ntawm 875 mg + 125 mg ob zaug ib hnub.

Txhawm rau kom ntsuas qhov tseeb ntawm koob tshuaj Augmentin kev ncua rau cov menyuam muaj hnub nyoog qis dua 3 hlis, nws pom zoo kom ntaus cov lej nrog ib rab koob uas muaj qhov cim. Txhawm rau kom siv txoj kev siv ncua kev kawm ntawv hauv cov menyuam yaus hauv qab ob xyoos, nws tau tso cai kom cov kua dej nrog cov dej hauv qhov piv rau 50/50

Augmentin's analogues, uas yog nws txoj kev hloov pauv chaw muag tshuaj, yog cov tshuaj Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Lub Ecoclave.

Cawv tau zoo

Augmentin thiab cawv yog qhov kev xav tsis yog kev tawm tsam los ntawm cov cawv cawv ethyl tshuaj tua kab mobtsis pauv nws lub zog pharmacological.

Yog tias tawm tsam keeb kwm ntawm kev siv tshuaj yeeb muaj qhov xav kom haus dej haus cawv, nws yog ib qho tseem ceeb kom soj ntsuam ob yam kev mob: kev sim thiab maj nrawm.

Rau tib neeg kev txom nyem los ntawm kev quav dej cawv, kev siv yeeb tshuaj nrog cawv ib txhij tuaj yeem muaj kev phom sij loj dua.

Kev siv dej cawv hauv cov dej cawv ua rau cuam tshuam nrog ntau yam kev ntxhov siab hauv kev ua haujlwm mob siabCov. Cov neeg mob nrog tus neeg mob mob siab cov kev qhia pom zoo hais tias Augmentin yuav tsum muaj kev ceev faj heev, vim tias nws tau kwv yees tias yuav ua li cas lub cev muaj kabmob yuav coj tus cwj pwm hauv kev sim kom tiv thaiv.xenobioticnyuaj heev.

Yog li, yuav kom zam kev pheej hmoo tsis txaus ntseeg, nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm tag nrho ntawm kev kho nrog cov tshuaj.

Augmentin thaum cev xeeb tub thiab lactation

Zoo li feem ntau cov tshuaj tua kab mob penicillin pawg, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag rau hauv niam mis. Ntxiv mus, kab lus ntau yuav txawm pom nyob hauv mis. clavulanic acid.

Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Hauv qee kis, kev sib xyaw ua ke clavulanic acid nrog amoxicillin tuaj yeem tsim nyob rau hauv tus menyuam zawv plab thiab / lossis candidiasis (thrush) ntawm cov hnoos qeev hauv lub qhov ncauj kab noj hniav.

Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.

Kev tshawb fawb tsiaj tau pom tias cov tshuaj nquag ntawm Augmentin muaj peev xwm nkag mus hematoplacental (GPB) teeb meemCov. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo rau kev loj hlob ntawm tus menyuam hauv plab.

Ntxiv mus, teratogenic teebmeem tau tsis tuaj nrog niam txiv kev coj noj coj ua thiab tshuaj noj ntawm qhov ncauj.

Kev siv cov Augmentin hauv cov poj niam cev xeeb tub tuaj yeem tuaj yeem coj mus rau kev loj hlob ntawm cov menyuam mos necrotizing enterocolitis (NEC).

Zoo li txhua lwm yam tshuaj, Augmentin tsis pom zoo rau cov poj niam cev xeeb tub. Thaum cev xeeb tub, nws siv tau rau qee qhov xwm txheej, raws li kws kho mob qhov kev ntsuas, qhov txiaj ntsig rau tus poj niam muaj ntau tshaj qhov txaus ntshai rau nws tus menyuam.

Kev txheeb xyuas txog Augmentin

Kev tshuaj xyuas ntawm cov ntsiav tshuaj thiab kev ncua rau cov me nyuam Augmentin rau feem ntau zooCov. Coob tus ntsuas cov tshuaj ua tshuaj tau txais txiaj ntsig zoo thiab ntseeg tau.

Ntawm cov chaw sib tham uas tib neeg qhia txog lawv cov kev xav ntawm qee yam tshuaj, cov qhab nia nruab nrab ntawm cov tshuaj tua kab mob yog 4,3-4.5 ntawm 5 lub ntsiab lus.

Cov kev tshuaj xyuas txog Augmentin tseg los ntawm leej niam ntawm cov menyuam yaus qhia tias cov cuab yeej pab tau daws sai sai nrog cov kab mob xws li mob thaum yau mob ntsws lossis mob caj pasCov. Ntxiv nrog rau qhov ua tau zoo ntawm cov tshuaj, cov niam kuj tseem nco qab nws cov qab ntxiag, uas cov menyuam nyiam.

Cov cuab yeej ua haujlwm kuj tseem muaj txiaj ntsig thaum cev xeeb tub. Txawm hais tias qhov tseeb hais tias qhov kev qhia tsis pom zoo kev kho mob nrog cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub sijhawm 1 lub sijhawm), Augmentin feem ntau yog txiav txim siab thib 2 thiab thib 3 txiav.

Raws li cov kws kho mob, qhov loj tshaj plaws thaum kho nrog cov cuab yeej no yog soj ntsuam qhov ntau npaum li cas thiab ua raws txhua qhov kev pom zoo ntawm koj tus kws kho mob.

Augmentin Nqe

Tus nqi ntawm Augmentin hauv Ukraine nws txawv nyob ntawm lub tsev muag tshuaj tshwj xeeb. Nyob rau tib lub sijhawm, tus nqi ntawm cov tshuaj yog me ntsis siab dua hauv cov khw muag tshuaj hauv Kiev, ntsiav tshuaj thiab kua txiv hauv cov chaw muag tshuaj hauv Donetsk, Odessa lossis Kharkov raug muag ntawm tus nqi me ntsis.

625 mg ntsiav tshuaj (500 mg / 125 mg) tau muag hauv khw muag tshuaj, ntawm thaj tsam, ntawm 83-85 UAH. Tus nqi nruab nrab ntawm Augmentin ntsiav tshuaj 875 mg / 125 mg - 125-135 UAH.

Koj tuaj yeem yuav cov tshuaj tua kab mob hauv cov hmoov ntawv rau kev npaj cov tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 500 mg / 100 mg ntawm cov tshuaj yeeb dej caw, ntawm qhov nruab nrab, rau 218-225 UAH, tus nqi nruab nrab ntawm Augmentin 1000 mg / 200 mg - 330-354 UAH.

Nqe ntawm Augmentin kev ncua rau cov menyuam yaus:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Mechanism ntawm kev ua

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj kev ua tau zoo txaus los tiv thaiv plasmid beta-lactamases, uas feem ntau txiav txim siab qhov tawm tsam ntawm cov kab mob, thiab tsis muaj kev tiv thaiv zoo tiv thaiv cov chromosomal beta-lactamases hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv kev npaj Augmentin tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Kev xa Khoom

Ib yam li kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob rau hauv ntau cov ntaub so ntswg thiab cov kua dej interstitial (nyob rau hauv lub qog, cov nqaij hauv lub plab, tawv nqaij, adipose thiab cov leeg nqaij, synovial thiab peritoneal kua, kua tsib, thiab purulent tawm). Cov.

Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin hauv ntshav plasma khi rau cov ntshav plasma protein.

Hauv kev tshawb nrhiav tsiaj, tsis muaj kev txuam ntawm lub Cheebtsam ntawm Augmentin® kev npaj hauv ib qho khoom hauv nruab nrog. Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Cov kab ntawm clavulanic acid kuj tseem yuav pom nyob hauv niam cov kua mis. Dhau ntawm qhov ua tau ntawm kev nkag siab, mob raws plab, lossis candidiasis ntawm lub qhov ncauj ua pa ntawm lub qhov ncauj, tsis muaj lwm qhov tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov menyuam mos-niam mis tau paub.

Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid hla qhov chaw teeb meem. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.

Kev zom zaub mov

10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum (penicilloic acid). Clavulanic acid tau dav dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1 H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxybutan-2-ib thiab tau tawm los ntawm lub raum los ntawm kev zom cov pa zom zaws, ntxiv rau nrog cov huab cua tas sijhawm hauv daim ntawv carbon dioxide.

Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.

Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid tau tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab kev siv tshuaj. Kev tswj hwm tib lub sij hawm ntawm probenecid qeeb ua rau tsis pom kev ntawm amoxicillin, tab sis tsis yog clavulanic acid.

Tsuas tshuaj thiab tswj hwm

Txog kev tswj hwm qhov ncauj.

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev. Txo kom txo tau qhov muaj peev xwm ua mob plab hnyuv twm thiab kom muaj qhov nqus tau zoo, kom cov tshuaj yuav tsum noj thaum noj mov. Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua cov kauj ruam kho mob (thawj zaug, kev tswj hwm txoj kev npaj ntawm Augmentin a nyob rau hauv ib daim ntawv tshuaj noj; hmoov rau kev npaj cov tshuaj rau kev tswj hwm nrog kev hloov mus tom qab Augmentin® hauv kev kho mob qhov ncauj).

Nws yuav tsum nco ntsoov tias 2 ntsiav tshuaj ntawm Augmentin® 250 mg + 125 mg tsis sib npaug rau ib ntsiav tshuaj ntawm Augmentin® 500 mg + 125 mg.

Cov neeg mob Hemodialysis

Cov koob tshuaj hloov kho yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin. 1 ntsiav tshuaj 500 mg + 125 mg hauv ib koob tshuaj txhua 24 teev

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (ib ntsiav tshuaj) thiab lwm lub ntsiav tshuaj tom kawg ntawm kev lim ntshav lim ntshav (kom them rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Cev xeeb tub

Hauv kev tshawb fawb ntawm kev ua me nyuam hauv cov tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin® tsis ua rau muaj teebmeem teratogenic. Hauv kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev xoos xoos, nws tau pom tias prophylactic kev siv tshuaj kho mob yuav cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin® tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias muaj kev cia siab rau tus niam tshaj qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Lub sijhawm pub mis niam

Cov tshuaj Augmentin® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev nkag siab, mob raws plab, lossis candidiasis ntawm lub qhov ncauj cov leeg ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov khoom xyaw tseem ceeb ntawm cov tshuaj no rau cov niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos lub mis. Thaum muaj qhov tshwm sim tsis zoo hauv cov menyuam yaus noj niam mis, kev pub mis niam yuav tsum tsis tsum.

Cov lus qhia tshwj xeeb

Ua ntej pib siv cov Augmentin, keeb kwm kev kho mob ntawm tus neeg mob yuav tsum txheeb xyuas qhov tshwm sim kev tiv thaiv tus kab mob siab rau penicillin, cephalosporin thiab lwm yam.

Augmentin Kev raug ncua yuav nyob nrog tus neeg mob cov hniav. Txhawm rau kom tsis txhob muaj kev txhim kho ntawm cov txiaj ntsig zoo li no, nws txaus los ua raws txoj cai ntawm kev tu lub qhov ncauj - txhuam koj cov hniav, siv yaug dej.

Kev nkag rau Augmentin yuav ua rau kiv taub hau, yog li rau lub sijhawm ntawm kev kho mob yuav tsum tsis txhob tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev mloog ntxiv.

Yuav siv tsis tau Augmentin yog tias xav tias tsam muaj mob mononucleosis uas xav tias muaj.

Augmentin muaj kev thev taus zoo thiab muaj tshuaj lom tsawg. Yog hais tias siv lub sijhawm ntev ntawm cov tshuaj yog qhov yuav tsum tau, ces nws yog qhov yuav tsum tau ua ntu zus los kuaj xyuas kev ua haujlwm ntawm lub raum thiab mob siab.

Nosological kev faib tawm (ICD-10)

1 Hauv kev tsim cov tshuaj, poov tshuaj clavulanate raug nteg nrog 5% ntau dhau.

1 Cov dej lim tawm hauv cov txheej txheej zaj duab xis.

Kev piav qhia ntawm daim ntawv tshuaj

Hmoov: dawb lossis yuav luag dawb, nrog tus yam ntxwv tsw. Thaum diluted, ib qho kev ncua ntawm dawb lossis yuav luag dawb yog tsim. Thaum sawv ntsug, ib qho dej dawb lossis dawb yuav luag nag lossis daus maj mam ua kom qeeb.

Ntsiav tshuaj, 250 mg + 125 mg: them nrog zaj duab xis membrane los ntawm dawb mus rau yuav luag dawb, kheej li lub qw hauv cov duab, nrog cov ntawv sau "AUGMENTIN" ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Ntsiav tshuaj, 500 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb hauv cov xim, oval, nrog cov ntawv sau extruded "AC" thiab txoj kev pheej hmoo ntawm ib sab.

Ntsiav tshuaj, 875 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb, kheej li lub qw, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab thiab ib txoj kab txhaum ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Cov Tshuaj Pharmacokinetics

Ob qho khoom xyaw tseem ceeb ntawm Augmentin ® kev npaj - amoxicillin thiab clavulanic acid - tau sai thiab tag nrho los ntawm kev mob plab zom mov tom qab kev tswj hwm ntawm qhov ncauj. Qhov nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj Augmentin ® yog qhov zoo dua rau thaum muaj kev noj tshuaj thaum pib noj mov.

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob siv 40 mg + 10 mg / kg / hnub ntawm Augmentin ® hauv peb koob tshuaj, hmoov rau lub qhov ncauj ncua, 125 mg + 31.25 mg hauv 5 ml (156.25 mg).

Yooj yim pharmacokinetic

Amoxicillin

Augmentin ®, 125 mg + 31.25 mg hauv 5 ml

Clavulanic acid

Augmentin ®, 125 mg + 31.25 mg hauv 5 ml

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2–12 xyoo rau ntawm lub plab khoob tau Augmentin ®, hmoov rau lub qhov ncauj ncua, 200 mg + 28.5 mg hauv 5 ml (228 , 5 mg) ntawm ib koob ntawm 45 mg + 6.4 mg / kg / hnub, muab faib ua ob zaug.

Yooj yim pharmacokinetic

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin ®, hmoov rau lub qhov ncauj ncua, 400 mg + 57 mg hauv 5 ml (457 mg).

Yooj yim pharmacokinetic

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb sib txawv, thaum cov neeg tuaj yeem yoo mov sai:

- 1 tab. Augmentin ®, 250 mg + 125 mg (375 mg),

- 2 ntsiav tshuaj Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 tab. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg ntawm amoxicillin,

- 125 mg ntawm clavulanic acid.

Yooj yim pharmacokinetic

Amoxicillin nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Clavulanic acid nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Thaum siv cov tshuaj Augmentin ®, ntshav ntau ntawm amoxicillin zoo ib yam li cov tshuaj noj ntawm qhov ncauj ntawm amoxicillin koob tshuaj sib npaug.

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb cais, thaum cov neeg tuaj yeem noj qab haus huv txaus noj:

- 2 ntsiav tshuaj Augmentin ®, 875 mg + 125 mg (1000 mg).

Yooj yim pharmacokinetic

Amoxicillin nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic acid nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Augmentin ®, 875 mg + 125 mg

Ib yam li iv kev tswj hwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob hauv ntau cov ntaub so ntswg thiab cov kua dej interstitial (gall zais zis, lub plab hauv plab, tawv nqaij, rog thiab cov leeg nqaij, synovial thiab peritoneal kua, kua tsib, kua paug) )

Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin hauv ntshav plasma khi rau cov ntshav plasma protein.

Hauv kev tshawb nrhiav tsiaj, tsis muaj kev txuam ntawm lub Cheebtsam ntawm Augmentin ® kev npaj hauv ib qho khoom hauv lub cev.

Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Cov kab ntawm clavulanic acid kuj tseem yuav pom nyob hauv niam cov kua mis. Tshwj tsis yog tias muaj peev xwm tsim kev mob plab zom mov thiab cov mob candidiasis ntawm cov quav ntawm lub qhov ncauj ntawm lub qhov ncauj, tsis muaj lwm qhov tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov menyuam mos-niam mis tau paub.

Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid hla qhov chaw teeb meem. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.

10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum rau lub cev (cov tshuaj penicilloic acid). Clavulanic acid tau dav dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid thiab amino-4-hydroxy-butan-2-ib thiab tau tawm ntawm cov raum Lub plab zom zaws, nrog rau cov huab cua uas tsis tas sijhawm nyob hauv daim ntawv cov roj carbon dioxide.

Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.

Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 lub rooj. 250 mg + 125 mg lossis 1 ntsiav tshuaj 500 mg + 125 mg.

Kev tswj hwm tib lub sij hawm ntawm probenecid qeeb ua rau qhov kev zam ntawm amoxicillin, tab sis tsis yog clavulanic acid (saib "Kev Sib Hloov").

Kev Taw Qhia Augmentin ®

Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:

cov mob ua pa sab sauv (suav nrog rau tus mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim Tus kab mob Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin ntsiav tshuaj 250 mg / 125 mg),

cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, mob ntsws mob ntsws, thiab mob ntsws, feem ntau tshwm sim Kab mob ntsws Streptococcus mob ntsws, Haemophilus khaub thuas 1 thiab Moraxella catarrhalis 1,

mob txeeb zig, xws li mob cystitis, tus mob urethritis, pyelonephritis, kis mob rau poj niam lub cev ua paug, feem ntau tshwm sim los ntawm hom tsiaj hauv tsev neeg Enterobacteriaceae 1 (feem ntau yog Escherichia coli 1 ), Dab Tsi Staphylococcus saprophyticus thiab hom Enterococcusli zoo li kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,

daim tawv nqaij thiab cov nqaij mos muag kis mob feem ntau tshwm sim Staphylococcus aureus 1, Tus kab mob Streptococcus pyogenes thiab hom Bacteroides 1,

kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim Staphylococcus aureus 1, yog tias tsim nyog, kho lub sijhawm ntev ntev yog qhov ua tau.

cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog nthuav tawm cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),

lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Cov neeg sawv cev ntawm cov kab mob tsis txawv txav tsim cov beta-lactamase, uas ua rau lawv tsis raug tshuaj amoxicillin (saib. Pharmacodynamics).

Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag. Augmentin ® tseem qhia txog kev kho mob sib kis los ntawm cov kab mob sib kis me me los ntawm amoxicillin, nrog rau cov kab mob me me uas tsim cov beta-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Cov kev nkag siab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av ntawd thiab sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.

Cev xeeb tub thiab lactation

Hauv kev tshawb fawb ntawm kev ua tiav tsiaj hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic.

Hauv txoj kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev puas ua ntej, nws tau pom tias kev tiv thaiv kev tiv thaiv nrog Augmentin ® tej zaum cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin ® tshuaj tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias cov kev cia siab pab rau leej niam muaj txiaj ntsig zoo ua rau muaj kev pheej hmoo rau menyuam hauv plab.

Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis. Thaum muaj qhov tshwm sim tsis zoo hauv cov menyuam yaus noj niam mis, kev pub mis niam yuav tsum tsis tsum.

Chaw tsim tshuaj paus

SmithKlein Puam P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.

Lub npe thiab chaw nyob ntawm tus neeg tuav txoj cai lij choj uas lawv sau npe rau daim ntawv pov thawj: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.

Xav paub ntau ntxiv, sib cuag: GlaxoSmithKline Trading CJSC. 121614, Moscow, st. Krylatskaya, 17, bldg. 3, pem teb 5. Kev Lag Luam Chaw Ua Si "Roob Krylatsky."

Xovtooj: (495) 777-89-00, fev: (495) 777-89-04.

Augmentin ® hnub tas sijhawm

zaj duab xis-ntsiav tshuaj 250 mg + 125 mg 250 mg + 125 - 2 xyoos.

zaj duab xis-coated ntsiav tshuaj 500 mg + 125 mg - 3 xyoos.

zaj duab xis-ntsiav tshuaj 875 mg + 125 mg - 3 xyoos.

hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj 125mg + 31.25mg / 5ml - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.