Tshuaj aspirin los yog acetylsalicylic acid

Puas yog acetylsalicylic acid zoo tib yam li tshuaj aspirin? Puas muaj qhov sib txawv tseem ceeb ntawm ob qho tshuaj? Cov tshuaj aspirin thiab acetylsalicylic acid ua haujlwm tib yam, thiab siv nyob rau hauv cov teb xws li kev kho plawv, kho mob, phais mob ntshav. Cov tshuaj aspirin yog lub npe lag luam rau acetylsalicylic acid.

Cov tshuaj aspirin yog rau cov pab pawg ntawm cov tshuaj uas tsis yog tshuaj steroidal, cov tshuaj ua kom nquag plias uas yog acetylsalicylic acid. Nws muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, uas muaj txog 500 mg ntawm cov tshuaj nquag, ua ke nrog pob kws hmoov txhuv nplej siab thiab microcrystalline cellulose. Qhov tseem ceeb, cov tshuaj no yog siv los ua cov tshuaj loog, thiab rau cov tshuaj tiv thaiv kab mob.

Noj cov ntsiav tshuaj noj ntawm qhov ncauj, hauv kev noj tshuaj txog 300 mg rau 1 g, daws qhov mob, tshem tawm qhov mob ntawm cov leeg thiab pob qij txha, thiab tseem tso cai rau koj ua kom muaj qhov mob me me ntawm qhov kub taub hau, piv txwv li, mob khaub thuas lossis mob khaub thuas. Tib koob tshuaj yog siv los txo qhov kub ntawm lub cev.

Cov yam ntxwv ntawm cov tshuaj no tso cai rau nws siv kuj muaj cov mob huam ceev, thaum siv tshuaj ntau dua yog siv nrog cov koob tshuaj ib txwm siv.

Cov tshuaj kuj tseem tuaj yeem siv los tiv thaiv kev tsim cov ntshav txhaws, uas yog ua tiav los ntawm kev tsim cov plasmaets.

Thaum noj tshuaj, muaj cov nram qab no contraindications:

Kev siv cov tshuaj no yog txwv thaum muaj kev fab tshuaj rau ob qho tib si cov tshuaj yeeb dej cawv nws tus kheej thiab nws cov khoom sib xyaw. Ib qho ntxiv, nws tsis pom zoo kom sau ntawv rau cov tshuaj no rau kev siv nyob rau hauv qhov muaj feem ntau nce siab los ntshav.

Cov hauv qab no yog suav tias yog kev txheeb ze tsis sib haum:

• tib txhij tswj hwm ntawm anticoagulants,
• theem tsis txaus ntawm cytosolic enzyme,
• mob ntsws asthma
• lub raum tsis ua hauj lwm zoo,
• muaj qhov muaj mob ntawm cov kab mob ntawm lub plab thiab duodenum,
• mob ntshav qab zib mellitus
• mob gout
• tsis tau muaj 12 xyoos
• cev xeeb tub
• pub niam mis.

Hauv qhov muaj tsawg kawg ntawm ib qho ntawm cov txheeb ze sib kis, kev noj tshuaj tsuas yog tom qab kev tso cai los ntawm tus kws kho mob tuaj koom.

Qhov kev tshwm sim ntawm cov kev mob tshwm sim tuaj yeem tshwm sim rau hauv daim ntawv ntawm kev tsis haum lub cev qhov tawv ncauj ntawm daim tawv nqaij, nrog rau kev txo qis ntawm cov ntshav platelet hauv cov ntshav thiab tshwm sim ntawm kev mob hauv plab. Txhua yam kev qhia paub ntawm lawv yuav tsum muaj kev ua haujlwm sai thiab kev kho mob rau tus kws kho mob.

Txais tos ntawm cov tshuaj aspirin, raws li kev qhia, yog nqa tawm sab hauv tom qab zaub mov noj, nrog kev ntxhua nrog kom muaj kua kom txaus. Qhov txwv ntawm kev tswj hwm tus kheej tsis muaj kev sab laj nrog koj tus kws kho mob yog muaj txog 5 hnub. Hauv tib lub koob tshuaj, nws yog kws kho mob hauv ib qho nyiaj ntawm 300 mg rau 1 g, nrog kev muaj peev xwm rov ua dua tom qab 4-8 teev. Qhov ntau kawg tshuaj rau txhua hnub yog 4g.

Acetylsalicylic acid

Cov tshuaj no muaj nyob hauv cov txee tshuaj ntawm tsev neeg feem ntau.

Thawj qhov hais txog acetylsalicylic acid tau rov qab mus rau thaum xaus ntawm lub xyoo pua puv 19, thiab muaj feem txuam nrog cov npe ntawm cov tub ntxhais hluas tus kws tshuaj Felix Hoffman, uas thaum lub sijhawm ntawd yog ib tug neeg ua haujlwm ntawm Bayer lub chaw muag tshuaj. Nws lub tswv yim tseem ceeb yog txhim kho txoj kev kho uas yuav pab tau nws txiv txoj kev hloov pauv ntawm qhov mob hauv nws lub hauv caug lub duav. Nov yog lub sij hawm teem ntsev sodium salicylate rau tus neeg mob. Nws tsuas yog drawback yog tus neeg mob lub cev tsis muaj peev xwm coj nws, vim qhov tseeb tias cov tshuaj ua rau mob hnyav ntawm lub plab zom mov.

Ob xyoos tom qab, daim ntawv tso cai rau cov tshuaj hu ua aspirin tau nyob hauv Berlin, qhov twg acetylsalicylic acid ua cov tshuaj yeeb tshuaj.

Cov tshuaj muaj cov tshuaj tiv thaiv, ua kom loog thiab tshuaj tua tsis tau, thiab tib lub sijhawm ua rau platelet sib sau ua ke.

Qhov ntsuas tshwj xeeb rau kev siv

Kev xyuam xim tshwj xeeb yuav tsum tau siv thaum kho mob rau cov neeg mob uas muaj ntau yam kab mob hauv lub siab thiab lub raum, mob ntsws asthma, mob rau lub plab thiab mob ntshav hauv txoj hnyuv, nce ntshav los yog txoj kev kho kom ncaj rau cov ntshav txhaws, decompensated mob plawv tsis ua haujlwm.

Kev siv txawm tias siv tshuaj me me tuaj yeem ua rau cov uric acid tsis tuaj yeem ua rau, uas ua rau muaj mob gout rau cov neeg mob uas muaj tus kabmob no. Yog tias tsim nyog, kev siv mus ntev yuav tsum muaj kev saib xyuas tas li los ntawm koj tus kws kho mob thiab saib xyuas qhov ntshav hemoglobin.
5-7 hnub ua ntej qhov kev phais mob thiab thaum lub sijhawm txiav txim siab tom qab, cov tshuaj ntawm pawg no yuav tsum tau tsum tsis ua haujlwm ntxiv.
Cov tshuaj noj ntawm cov pab pawg no yog siv rau lub pob ntseg mob hlwb, siab ntau ntawm kev mob plawv, mob plawv.

Sab sij huam

Kev siv ntev ntev tuaj yeem ua rau lub hauv nruab nrab cov hlab ntsha hlwb tsis zoo xws li kiv taub hau, tinnitus, thiab tsis pom kev. Kuj tseem yuav muaj lub sijhawm ua kom ntshav khov ntau ntxiv, lub raum khiav tsis zoo, thiab lub raum khiav tsis zoo. Kev ceev faj yuav tsum tau siv thaum kev noj tshuaj hauv poj niam cev xeeb tub.

Yog tib yam los yog tib yam?

Puas muaj qhov sib txawv ntawm ob cov tshuaj no? Yog tias koj paub koj tus kheej nrog cov lus qhia ntawm ob qho tshuaj, nws hloov tawm tias qhov sib txawv tsuas yog qhov ntau npaum. Tshuaj aspirin muaj nyob rau hauv ntau npaum 100, 300 thiab 500 mg. Acetylsalicylic acid yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, ntau npaum ntawm yog 250 thiab 500 mg.

Cov Tshuaj Hauv Tshuaj

Qhov kev ua kom loog no yog vim ob qho tib si nruab nrab thiab ntu kev ua haujlwm. Nyob rau hauv cov ntaub ntawv ntawm febrile, nws txo qhov kub los ntawm kev ua ntawm qhov chaw thermoregulation.

Kev Sib Thuam thiab platelet nplaumli qub mob ntsws vwm txo qis vim yog lub peev xwm ntawm ASA los rhuav tshem qhov kev sib txuas ntawm thromboxane A2 (TXA 2) hauv platelets. Inhibits hluavtaws prothrombin (coagulation factor II) hauv daim siab thiab - hauv ib koob tshuaj ntau tshaj 6 g / hnub. - nce PTV.

Cov Tshuaj Pharmacokinetics

Kev nqus cov tshuaj tom qab siv cov tshuaj hauv sab hauv yuav luag tiav. Lub sijhawm ib nrab ntawm kev tshem tawm ntawm cov tsis hloov pauv ASA tsis pub tshaj 20 feeb. TCmax ASA hauv - 10-20 feeb, tag nrho cov ntsev uas tshwm sim los ntawm - ntawm 0.3 txog 2.0 teev.

Li ntawm 80% ntawm cov ntshav tau cog lus lub xeev acetylsalicylic thiab salicylic acidsCov. Kev ua xyem xyav xyoob ntoo txawm tias lub cev nyob hauv daim ntawv protein.

Cov tshuaj txiav tawm hauv daim siab. Nws yog tawm los ntawm lub raum. Kev txiav tawm yog cuam tshuam los ntawm cov zis pH: thaum acidified, nws txo qis, thiab thaum alkalized, nws nce.

Cov tshuaj Pharmacokinetic ntsuas nyob ntawm seb qhov loj npaum li cas ntawm cov tshuaj npaum li cas. Kev tshem tawm cov khoom muag yog nonlinear. Ntxiv mus, hauv cov menyuam yaus ntawm 1 xyoo ntawm lub neej, hauv kev sib piv nrog cov neeg laus, nws ua tiav qeeb qeeb ntau dua.

Cov Yuav Tsum Muaj

Nkag tau ASA yog contraindicated nyob rau hauv:

• Tshuaj aspirin hawb pob,
• lub sij hawm exacerbation erosive thiab ulcerative txhab ntawm lub kwj dej digestive,
• pais plab / plab hnyuv los ntshav,
• muaj vitamin K tsis txaus,
• hemophilia, hypoprothrombinemia, hemorrhagic diathesis,
• G6PD tsis muaj peev xwm,
• portal tawg,
• raum / mob siab ua haujlwm
• aortic dissection
• nyob rau lub sijhawm kho (yog tias ib zaug ib hlis ib zaug ntawm cov tshuaj ntau dua 15 / mg),
• gouty mob caj dab, gout,
• (thawj peb thiab peb lub hlis yog meej contraindications),
• muaj qhov tsis haum rau ASA / salicylates.

Kev siv ntawm ASA hauv cosmetology

Acetylsalicylic acid lub ntsej muag lub ntsej muag ua rau koj tshem tawm qhov mob sai sai, txo qhov nqaij o, tshem tawm liab, tshem cov txheej txheej saum npoo ntawm cov leeg tuag thiab ntxuav qhov hws ua paug.

Cov tshuaj ntws tawm ntawm daim tawv nqaij zoo thiab muaj tshuaj lom rau hauv cov rog, uas ua rau nws tsim nyog siv rau kev kho pob txuv: ntsiav tshuaj moistened nrog dej, thov rau cuam tshuam ntsiab ntawm lub ntsej muag los yog ntxiv rau qhov muaj pes tsawg leeg lub ntsej muag lub ntsej muag.

Acetylsalicylic acid los ntawm pob txuv ua haujlwm zoo hauv kev sib xyaw nrog txiv qaub kua txiv lossis zib ntab. Ua tau zoo rau kev daws teeb meem ntawm daim tawv nqaij thiab npog ntsej muag nrog av nplaum.

Txhawm rau npaj lub txiv qaub-tshuaj aspirin lub ntsej muag, ntsiav tshuaj (6 daim) tsuas yog hauv av nrog cov kua txiv tshiab kom txog thaum muaj ib homogeneous loj tau. Tom qab ntawv cov tshuaj muaj kiav rau khaus cov pob txuv thiab sab laug rau lawv kom txog thaum qhuav.

Daim npog ntsej muag nrog zib ntab yog npaj raws li hauv qab no: ntsiav tshuaj (3 daim) yog noo noo nrog dej, thiab tom qab ntawd, thaum lawv yaj tag, tov nrog 0.5-1 tablespoon (tshuaj yej) zib ntab.

Txhawm rau npaj daim npog av nplaum, 6 qhov ntxuaj ntawm ASA thiab 2 diav (me nyuam diav) ntawm cov xim dawb / xiav av yuav tsum tov nrog dej sov.

Noj ntau dhau

Kev noj ntau dhau yuav tshwm sim los ntawm:

• kev kho mob ncua ntev ntawm ASA,
• ib qho kev tswj hwm ntawm qhov siab ntau dhau ntawm cov tshuaj.

Yog tus kos npe overdose salicylism syndrome, tshwm sim los ntawm dav dav malaise, hyperthermia, tinnitus, xeev siab, ntuav.

Muaj zog nrog spasms, neeg ruam, muaj dej tsis txaus, non-cardiogenic lub ntsws, CBS kev ua txhaum, kev poob siab.

Yog tias muaj neeg coob dhau ntawm ASA, tus neeg raug tsim txom yuav tsum tau mus tom tsev kho mob sai. Nws lub plab ntxuav, muab, tshawb xyuas los ntawm CBS.

Ua raws li cov xwm txheej ntawm WWTP thiab kev sib npaug ntawm dej thiab electrolytes, kev qhia txog kev daws teeb meem tuaj yeem ua raws, sodium citrate thiab sodium bicarbonate (raws li ib tug Txoj kev lis ntshav)

Yog tias pH tso zis yog 7.5-8.0, thiab cov ntshav plasma concentration ntawm salicylates ntau dua 300 mg / l (hauv menyuam yaus) thiab 500 mg / l (hauv cov neeg laus), yuav tsum tau saib xyuas mob hnyav alkaline diuretics.

Nrog rau intoxication hnyav nqa tawm, hloov ua kua dej kom tsawg, muab tshuaj kho mob.

Kev sib txuam

Txhim kho kev mob toxicity barbiturate npaj,valproic acid, methotrexatecov teebmeem ntawm qhov ncauj hypoglycemic tus neeg sawv cev, narcotic, tshuaj sulfa.

Tsis muaj zog cov teebmeem tshuaj kho mob (potassium-sparing thiab ntxau rov qab), antihypertensive tshuaj ACE inhibitorsuricosuric tus neeg sawv cev.

Nrog tib lub sijhawm siv nrog antithrombotic tshuaj, thrombolytics,indirect anticoagulants nce kev pheej hmoo uas los ntshav.

GCS txhim kho cov nyhuv ua kom tsis zoo ntawm ASA rau ntawm qhov hnoos qeev ntawm lub plab zom mov, ua kom nws txoj kev tshem tawm thiab txo cov ntshav plasma.

Thaum siv ua ke nrog cov ntsev ntsev, Li nce ntxiv ntawm plasma concentration ntawm Li + ions.

Txhim kho lub tshuaj lom cawv ntawm cawv rau lub mucosa ntawm lub plab zom mov.

Cov lus qhia tshwj xeeb

Cov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg nrog pathologies ntawm ob lub raum thiab mob siab, nrog rau cov ntshav nce ntxiv, decompensated lub plawv tsis ua haujlwm, thaum kho mob nrog anticoagulants, zoo li hauv cov neeg muaj keeb kwm ntawmerosive thiab ulcerative lesions ntawm lub plab zom mov thiab / lossis pais plab / plab hnyuv los ntshav.

Txawm hais tias nyob rau hauv cov koob tshuaj me me, ASA txo cov kev pom zoo. uric aciduas nyob rau hauv cov neeg mob raug tau yuav ua rau muaj mob hnyav mob gout.

Thaum noj tshuaj ASA ntau dua lossis xav tau kev kho mob mus ntev nrog cov tshuaj, nws yog ib qho yuav tsum tau soj ntsuam cov qib tas li thiab raug pom los ntawm tus kws kho mob.

Ua tus neeg sawv cev tiv thaiv kab mob, siv tshuaj ASA hauv ib koob li 5-8 g / hnub. txwv vim muaj ntau qhov kev pheej hmoo ntawm kev phiv tshuaj los ntawm cov hnyuv plab hnyuv.

Txhawm rau txo qis los ntshav thaum phais thiab tom qab lub sijhawm txiav, tom qab noj salicylates nres 5-7 hnub ua ntej kev phais mob.

Thaum noj tshuaj ASA, nws yuav tsum nco ntsoov tias qhov tshuaj no tuaj yeem noj tsis pub dhau 7 hnub yam tsis tau sab laj nrog kws kho mob. Ua tshuaj tua kabmob ASA, nws raug tso cai rau haus tsis pub ntau tshaj 3 hnub.

Tshuaj lom neeg lub zog ntawm cov tshuaj

Thaum ASA crystallizes, koob tsis muaj kob los yog monoclinic polyhedra nrog saj me ntsis qaub yog tsim. Cov muaju yog ruaj khov nyob rau hauv huab cua qhuav, tab sis nrog nce av noo, lawv maj mam hydrolyze rau salicylic thiab acetic acids.

Cov tshuaj nyob rau hauv nws daim ntawv dawb huv yog crystalline hmoov ntawm cov xim dawb thiab ua ntxhiab tsw. Cov tsos ntawm tsis hnov ​​tsw ntawm acetic acid yog qhov taw qhia tias cov tshuaj pib hydrolyze.

kis mob , vim tias qhov kev sib koom ua ke no tuaj yeem ua rau kev txhim kho kev mob tuag taus rau tus menyuam - Reye's syndrome.

Hauv cov menyuam mos yug tshiab, salicylic acid tuaj yeem txav vim albumin bilirubin thiab txhawb kev tsim kho txha caj qaum.

ASA nkag mus yooj yim rau txhua lub cev ntawm lub cev thiab cov nqaij, nrog rau cerebrospinal, synovial thiab peritoneal kua.

Nyob rau hauv qhov muaj edema thiab o, qhov nkag ntawm salicylate rau hauv kev sib koom ua ke tau nrawm. Hauv theem ntawm kev mob, ntawm qhov tsis sib xws, nws ua rau qeeb.

Siv thaum cev xeeb tub thiab pub niam mis

Acetylsalicylic acid yog sib kis thaum cev xeeb tub. Tshwj xeeb hauv thawj peb thiab peb lub hlis ntawm kev ua kom tes taw. Hauv cov theem thaum ntxov, kev noj cov tshuaj tuaj yeem ua rau muaj kev pheej hmoo ntawm kev pheej hmoo tsis zoo thaum yug menyuam, hauv theem tom ntej - hla kev xeeb tub thiab kev ua haujlwm tsis muaj zog.

ASA thiab nws cov metabolites hauv cov khoom me me txeem rau hauv cov mis. Tom qab kev tswj hwm kev siv tshuaj yaj yeeb, kev mob tshwm sim tsis pom hauv cov menyuam mos, yog li ntawd, raws li txoj cai, cuam tshuam ntawm kev pub niam mis (HB) tsis tsim nyog.

Yog tias tus poj niam pom tias kho mob ntev ntev nrog kev siv tshuaj ntau ntawm ASA, nws yog qhov tsim nyog yuav tsum txiav tawm HB.

Cov lus qhia rau kev siv:

Acetylsalicylic acid yog cov tshuaj uas muaj kev tiv thaiv kev tiv thaiv, antipyretic, analgesic thiab antiaggregant (txo platelet adhesion) cov nyhuv.

Nws zoo ib yam

Aspirin thiab acetylsalicylic acid yog ib qho thiab tib yam tshuaj. Kev lag luam daim ntawv ntawm lub npe - tshuaj aspirin, tau txais dav dav thoob plaws ntiaj teb, tab sis cov npe ntawm cov tshuaj analogues, tshuaj lom neeg ntawm salicylic acid nyob rau hauv lub ntiaj teb pauv - txog 400 (anopyrine, aspilite, apo-asa, thiab lwm yam). Salicylates pom muaj nyob hauv cov tawv ntoo uas tsis muaj qhov txhab, uas tau siv hauv tshuaj ntsuab los kho tus mob ua npaws, mob gout, thiab mob mob.

Nws suav hais tias yog cov tshuaj naj npawb 1 rau mob taub hau thiab kub lub cev. Tsis tas li, acetylsalicylic acid muaj cov nyhuv ua rau tiv thaiv, inhibiting zus tau tej cov prostaglandins - cov neeg kho kom haum cov txheej txheem hauv lub cev.

Qhov teebmeem antipyretic ntawm cov kua qaub no yog nyob ntawm nws lub peev xwm los tiv thaiv kev ua haujlwm ntawm qhov chaw ntawm lub paj hlwb uas tswj cov thermoregulation. Thaum qhov kub dhau los ua siab dhau lawm thiab ua kom puas tsuaj rau lub cev, cov ntsiav tshuaj sai thiab rau ob peb teev "khob" nws mus rau qhov tseem ceeb.

Lub tswv yim ntawm cov kws kho mob

Dmitry Vladimirovich, kws phais plawv: "Ib qho tshuaj zoo thiab pheej yig rau kev tiv thaiv lub plawv nres. Kuv xav kom cov ntsiav tshuaj enteric-txo kom tsis txhob muaj qhov tsis zoo tshwm sim ntawm lub plab hnyuv. ”

Konstantin Vitalievich, tus kws tshaj lij: “Cov tshuaj muaj txiaj ntsig zoo li tau khaub thuas, tshem tawm cov tsos mob thiab mob sib kis. Nrog rau siv ntev, koj tuaj yeem mob txhaws qog, ua rau muaj kev pheej hmoo los ntshav los ntawm lub plab zom mov. "

Sergey Alexandrovich, kws kho qhov muag: “Aspirin tuaj yeem raug hu ua cov tshuaj ntawm xyoo pua, uas muaj nws qhov zoo thiab qhov tshwm sim. Koj tsis tuaj yeem tsis maj mam noj, xav tias nws zoo ib yam li cov vitamins. Nws yog contraindicated nyob rau hauv cov neeg tsis taus lub raum thiab hepatic muaj nuj nqi. "

Kev Ntsiav Rau Neeg Mob rau Aspirin thiab Acetylsalicylic Acid

Denis, 25 xyoosRostov: “Cov tshuaj aspirin tau dhau los ua ib qho tshuaj tseem ceeb rau kuv, lub caij nplooj zeeg kuv feem ntau tau khaub thuas thiab tau siv los ua antipyretic thiab tiv thaiv. Kuv yeej tsis tau muaj kev phiv tshuaj li. ”

Irina Fedorovna, 43 xyoo, Ryazan: “Acetylka yog qhov qub, kho tau qhov tseeb, ib txwm muaj nyob hauv kuv cov khoom siv ua ntej. Thaum kuv xav tias kuv muaj mob, kuv ua ib yam li kuv txiv: Kuv noj 2 lub tshuaj ib hmos thaum sawv ntxov thiab zoo dua li qhov tshiab. ”

Natalia, 30 xyoo, Tula: “Cov tshuaj no yog qhov tseem ceeb, muaj ntau npaum li cas tau pab nrog mob khaub thuas! Kuv niam pog haus nws nrog mob hauv cov leeg thiab pob qij txha, nws hais tias, pab. Qhov tsuas yog qhov tseeb nws tuaj yeem siv tsis tau los ntawm cov poj niam cev xeeb tub hauv 1 thiab thib peb txoj kev txiav tawm, nrog rau thaum coj khaub ncaws. Aspirin-based lub qhov ncauj qhov ntswg zoo kawg nkaus ntxuav thiab ua kom khaus tawv nqaij. ”

Tshuaj aspirin thiab nws muaj pes tsawg leeg

Ua raws li kev faib cov tshuaj kho mob feem ntau, Cov tshuaj Aspirin tau faib ua cov tshuaj tiv thaiv kev tiv thaiv, ua kom loog nrog rau kev ua kom dav. Ntxiv nrog rau kev ua rau ntawm qhov chaw mob, cov tshuaj no yog siv los tiv thaiv cov hlab plawv.

Cov ntaub ntawv tso tawm ntawm Aspirin yog ntau yam. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm soluble raws li cov pa tshuaj. Tsis hais txog ntawm daim ntawv tso tawm, lub hauv paus tseem ceeb ntawm Aspirin yog acetylsalicylic acid, uas yog lub luag haujlwm rau lub luag haujlwm tseem ceeb pharmacological.

Ib zaug hauv lub cev, cov tshuaj ua kom nquag plias yuav nqus tau los ntawm txoj hnyuv hauv lub cev. Vim tias kev ua haujlwm ntawm daim siab ua haujlwm thiab kev ua ntawm nws cov enzymes, acetylsalicylic acid tau hloov mus rau hauv cov tshuaj metabolite. Nws yog nws qhov kev ua uas pab txo kom sov lossis tshem tawm mob. Nrog kev ua haujlwm sib xyaw ua ke ntawm tag nrho cov kab mob, cov tshuaj raug tshem tawm kom huv hauv peb hnub.

Hauv cov chaw muag tshuaj niaj hnub, acetylsalicylic acid tau los ntawm kev sib cuam tshuam ntawm salicylic thiab sulfuric acids nrog acetic anhydride. Cov tshuaj muaju tau sib xyaw nrog cov hmoov txhuv nplej siab thiab tau txais cov tshuaj zoo.

Pharmacological kev txiav txim

Cov tshuaj txo cov mob, kub thiab ocuam ​​tshuam nrog kev suav sau.

Pharmacological pawg: NSAIDs.

Pharmacodynamics thiab pharmacokinetics

Acetylsalicylic acid - nws yog dab tsi?

Acetylsalicylic acid yog salicylic ester ntawm acetic (ethanoic) acid.

Cov qauv ntawm cov tshuaj acetylsalicylic acid yog (ASA) - C₉H₈O₄.

OKPD code 24.42.13.142 (acetylsalicylic acid sib xyaw nrog lwm cov tshuaj).

Txais ASA

Hauv kev tsim cov ASA, txoj kev ntawm esterification nrog ethanoic acid yog siv.

Cov Tshuaj Hauv Tshuaj

Qhov kev ua kom loog no yog vim ob qho tib si nruab nrab thiab ntu kev ua haujlwm. Nyob rau hauv cov ntaub ntawv ntawm febrile, nws txo qhov kub los ntawm kev ua ntawm qhov chaw thermoregulation.

Kev Sib Thuam thiab platelet nplaumli qub mob ntsws vwm txo qis vim yog lub peev xwm ntawm ASA los rhuav tshem qhov kev sib txuas ntawm thromboxane A2 (TXA 2) hauv platelets. Inhibits hluavtaws prothrombin (coagulation factor II) hauv daim siab thiab - hauv ib koob tshuaj ntau tshaj 6 g / hnub. - nce PTV.

Cov Tshuaj Pharmacokinetics

Kev nqus cov tshuaj tom qab siv cov tshuaj hauv sab hauv yuav luag tiav. Lub sijhawm ib nrab ntawm kev tshem tawm ntawm cov tsis hloov pauv ASA tsis pub tshaj 20 feeb. TCmax ASA hauv - 10-20 feeb, tag nrho cov ntsev uas tshwm sim los ntawm - ntawm 0.3 txog 2.0 teev.

Li ntawm 80% ntawm cov ntshav tau cog lus lub xeev acetylsalicylic thiab salicylic acidsCov. Kev ua xyem xyav xyoob ntoo txawm tias lub cev nyob hauv daim ntawv protein.

Cov tshuaj txiav tawm hauv daim siab. Nws yog tawm los ntawm lub raum. Kev txiav tawm yog cuam tshuam los ntawm cov zis pH: thaum acidified, nws txo qis, thiab thaum alkalized, nws nce.

Cov tshuaj Pharmacokinetic ntsuas nyob ntawm seb qhov loj npaum li cas ntawm cov tshuaj npaum li cas. Kev tshem tawm cov khoom muag yog nonlinear. Ntxiv mus, hauv cov menyuam yaus ntawm 1 xyoo ntawm lub neej, hauv kev sib piv nrog cov neeg laus, nws ua tiav qeeb qeeb ntau dua.

Qhov ntsuas rau kev siv: vim li cas cov tshuaj acetylsalicylic acid pab tau?

Kev qhia rau kev siv cov tshuaj acetylsalicylic acid yog:

• febrile kab mob nyob rau hauv kis thiab mob kab mob,
• rheumatoid mob caj dab,
• mob rwj,
• mob txhab myocardiumtshwm sim los ntawm cov tshuaj tiv thaiv immunopathological,
• kev hnov ​​mob mob ntawm ntau lub hauv paus pib, nrog rau mob hniav (nrog rau mob taub hau cuam tshuam nrog haus cawv haus cawv), mob pob txha thiab mob leeg, neuralgia, migraines,algomenorrhea.

Ib yam ntxiv tshuaj aspirin (los yog acetylsalicylic acid) yog siv los ua prophylactic yog tias raug teeb meem mob ntsws vwm,thromboembolism, MI (thaum cov tshuaj raug txwv rau kev tiv thaiv theem ob).

Cov Yuav Tsum Muaj

Nkag tau ASA yog contraindicated nyob rau hauv:

• Tshuaj aspirin hawb pob,
• lub sij hawm exacerbation erosive thiab ulcerative txhab ntawm lub kwj dej digestive,
• pais plab / plab hnyuv los ntshav,
• muaj vitamin K tsis txaus,
• hemophilia, hypoprothrombinemia, hemorrhagic diathesis,
• G6PD tsis muaj peev xwm,
• portal tawg,
• raum / mob siab ua haujlwm
• aortic dissection
• nyob rau lub sijhawm kho (yog tias ib zaug ib hlis ib zaug ntawm cov tshuaj ntau dua 15 / mg),
• gouty mob caj dab, gout,
• (thawj peb thiab peb lub hlis yog meej contraindications),
• muaj qhov tsis haum rau ASA / salicylates.

Sab sij huam

Kev phiv los ntawm kev kho mob ASA tuaj yeem tshwm sim nyob rau hauv daim ntawv ntawm:

Nrog rau siv ntev, tinnitus tshwm sim, hnov ​​pob ntseg poob qis, qhov muag pom tsis hnov ​​lus, kiv taub hau tshwm sim thiab, nrog cov koob tshuaj siab, mob taub hau. Los ntshav tseem ua tau. hypocoagulationntuav bronchospasm.

Acetylsalicylic acid, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Ntawm nquag rheumatism cov neeg mob cov laus tau muab los ntawm 5 txog 8 g ntawm ASA ib hnub. Rau tus me nyuam, qhov tshuaj tau muab suav xam raws qhov hnyav. Raws li txoj cai, nws txawv ntawm 100 txog 125 mg / kg / hnub. Kev ntau ntau ntawm kev siv - 4-5 p. / Hnub.

1-2 lub lis piam tom qab pib qhov pib, qhov tshuaj rau tus menyuam raug txo mus rau 60-70 mg / kg / hnub, rau cov neeg mob laus, qhov tshuaj tsuas zoo li qub. Txuas ntxiv kev kho kom txog 6 lub lis piam.

Raws li cov lus qhia rau kev siv cov tshuaj acetylsalicylic acid, cov tshuaj yuav tsum tau txiav tawm maj mam dhau lub sijhawm 1-2 lub lis piam.

Acetylsalicylic acid rau mob taub hau thiab ua cov tshuaj kho rau qhov kub thiab txias yog tau hais tias noj tsawg dua. Yog li, nrog kev hnov ​​mob mob thiab febrile tej yam kev mob koob tshuaj rau 1 koob tshuaj rau ib tus neeg laus - los ntawm 0.25 txog 1 g nrog rau qhov tso cai ntawm daim ntawv thov los ntawm 4 txog 6 rubles ib hnub.

Nws yuav tsum nco ntsoov tias yog tias mob taub hau, ASA ua haujlwm tshwj xeeb yog tias qhov mob tshwm sim los ntawm qhov nce hauv ICP (mob siab intracranial).

Rau cov menyuam yaus, kev noj tshuaj zoo ntau ntawm lub sijhawm yog 10-15 mg / kg. Kev ntau ntau ntawm cov ntawv thov - 5 p. / Hnub.

Txoj kev kho yuav tsum tsis pub ntev tshaj 2 lub lis piam.

Rau kev ceeb toom mob ntsws vwm thiab embolism ASA noj 2-3 p. / Hnub. 0.5 g txhua. Txhawm rau txhim kho rheological zog (rau kev zom taus), cov tshuaj tau tshwm sim rau lub sijhawm ntev ntawm 0.15-0.25 g / hnub.

Rau cov menyuam yaus hnub nyoog qis dua tsib xyoos, noj ib zaug yog 0.25 g, menyuam yaus uas muaj plaub xyoos pub rau 0,2 g ntawm ASA ib zaug, cov menyuam muaj ob xyoos - 0.1 g, thiab ib xyoos - 0.05 g.

Nws yog txwv tsis pub muab ASA rau menyuam yaus los ntawm qhov kub uas nce hauv qhov tom qab kis mobCov. Cov tshuaj ua rau tib lub hlwb thiab lub siab ua qauv qee cov kab mob, thiab ua ke nrog kis mob tuaj yeem ua rau menyuam loj hlobReye's syndrome.

Kev siv ntawm ASA hauv cosmetology

Acetylsalicylic acid lub ntsej muag lub ntsej muag ua rau koj tshem tawm qhov mob sai sai, txo qhov nqaij o, tshem tawm liab, tshem cov txheej txheej saum npoo ntawm cov leeg tuag thiab ntxuav qhov hws ua paug.

Cov tshuaj ntws tawm ntawm daim tawv nqaij zoo thiab muaj tshuaj lom rau hauv cov rog, uas ua rau nws tsim nyog siv rau kev kho pob txuv: ntsiav tshuaj moistened nrog dej, thov rau cuam tshuam ntsiab ntawm lub ntsej muag los yog ntxiv rau qhov muaj pes tsawg leeg lub ntsej muag lub ntsej muag.

Acetylsalicylic acid los ntawm pob txuv ua haujlwm zoo hauv kev sib xyaw nrog txiv qaub kua txiv lossis zib ntab.Ua tau zoo rau kev daws teeb meem ntawm daim tawv nqaij thiab npog ntsej muag nrog av nplaum.

Txhawm rau npaj lub txiv qaub-tshuaj aspirin lub ntsej muag, ntsiav tshuaj (6 daim) tsuas yog hauv av nrog cov kua txiv tshiab kom txog thaum muaj ib homogeneous loj tau. Tom qab ntawv cov tshuaj muaj kiav rau khaus cov pob txuv thiab sab laug rau lawv kom txog thaum qhuav.

Daim npog ntsej muag nrog zib ntab yog npaj raws li hauv qab no: ntsiav tshuaj (3 daim) yog noo noo nrog dej, thiab tom qab ntawd, thaum lawv yaj tag, tov nrog 0.5-1 tablespoon (tshuaj yej) zib ntab.

Txhawm rau npaj daim npog av nplaum, 6 qhov ntxuaj ntawm ASA thiab 2 diav (me nyuam diav) ntawm cov xim dawb / xiav av yuav tsum tov nrog dej sov.

Noj ntau dhau

Kev noj ntau dhau yuav tshwm sim los ntawm:

• kev kho mob ncua ntev ntawm ASA,
• ib qho kev tswj hwm ntawm qhov siab ntau dhau ntawm cov tshuaj.

Yog tus kos npe overdose salicylism syndrome, tshwm sim los ntawm dav dav malaise, hyperthermia, tinnitus, xeev siab, ntuav.

Muaj zog nrog spasms, neeg ruam, muaj dej tsis txaus, non-cardiogenic lub ntsws, CBS kev ua txhaum, kev poob siab.

Yog tias muaj neeg coob dhau ntawm ASA, tus neeg raug tsim txom yuav tsum tau mus tom tsev kho mob sai. Nws lub plab ntxuav, muab, tshawb xyuas los ntawm CBS.

Ua raws li cov xwm txheej ntawm WWTP thiab kev sib npaug ntawm dej thiab electrolytes, kev qhia txog kev daws teeb meem tuaj yeem ua raws, sodium citrate thiab sodium bicarbonate (raws li ib tug Txoj kev lis ntshav)

Yog tias pH tso zis yog 7.5-8.0, thiab cov ntshav plasma concentration ntawm salicylates ntau dua 300 mg / l (hauv menyuam yaus) thiab 500 mg / l (hauv cov neeg laus), yuav tsum tau saib xyuas mob hnyav alkaline diuretics.

Nrog rau intoxication hnyav nqa tawm, hloov ua kua dej kom tsawg, muab tshuaj kho mob.

Kev sib txuam

Txhim kho kev mob toxicity barbiturate npaj,valproic acid, methotrexatecov teebmeem ntawm qhov ncauj hypoglycemic tus neeg sawv cev, narcotic, tshuaj sulfa.

Tsis muaj zog cov teebmeem tshuaj kho mob (potassium-sparing thiab ntxau rov qab), antihypertensive tshuaj ACE inhibitorsuricosuric tus neeg sawv cev.

Nrog tib lub sijhawm siv nrog antithrombotic tshuaj, thrombolytics,indirect anticoagulants nce kev pheej hmoo uas los ntshav.

GCS txhim kho cov nyhuv ua kom tsis zoo ntawm ASA rau ntawm qhov hnoos qeev ntawm lub plab zom mov, ua kom nws txoj kev tshem tawm thiab txo cov ntshav plasma.

Thaum siv ua ke nrog cov ntsev ntsev, Li nce ntxiv ntawm plasma concentration ntawm Li + ions.

Txhim kho lub tshuaj lom cawv ntawm cawv rau lub mucosa ntawm lub plab zom mov.

Cov nqe lus ntawm kev muag khoom

OTC cov khoom.

Daim ntawv qhia ua lus Latin (piv txwv):

Rp: Acidi acetylsalicylici 0.5
D. t. d. N 10 nyob rau hauv tab.
S. 1 ntsiav tshuaj 3 r. / Hnub tom qab noj mov tas, haus dej ntau.

Cia rau cov neeg mob

Cov ntsiav tshuaj yuav tsum tau muab cia rau hauv qhov chaw qhuav ntawm qhov kub qis dua 25 ° C.

Hnub tas sij hawm

Cov lus qhia tshwj xeeb

Cov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg nrog pathologies ntawm ob lub raum thiab mob siab, nrog rau cov ntshav nce ntxiv, decompensated lub plawv tsis ua haujlwm, thaum kho mob nrog anticoagulants, zoo li hauv cov neeg muaj keeb kwm ntawmerosive thiab ulcerative lesions ntawm lub plab zom mov thiab / lossis pais plab / plab hnyuv los ntshav.

Txawm hais tias nyob rau hauv cov koob tshuaj me me, ASA txo cov kev pom zoo. uric aciduas nyob rau hauv cov neeg mob raug tau yuav ua rau muaj mob hnyav mob gout.

Thaum noj tshuaj ASA ntau dua lossis xav tau kev kho mob mus ntev nrog cov tshuaj, nws yog ib qho yuav tsum tau soj ntsuam cov qib tas li thiab raug pom los ntawm tus kws kho mob.

Ua tus neeg sawv cev tiv thaiv kab mob, siv tshuaj ASA hauv ib koob li 5-8 g / hnub. txwv vim muaj ntau qhov kev pheej hmoo ntawm kev phiv tshuaj los ntawm cov hnyuv plab hnyuv.

Txhawm rau txo qis los ntshav thaum phais thiab tom qab lub sijhawm txiav, tom qab noj salicylates nres 5-7 hnub ua ntej kev phais mob.

Thaum noj tshuaj ASA, nws yuav tsum nco ntsoov tias qhov tshuaj no tuaj yeem noj tsis pub dhau 7 hnub yam tsis tau sab laj nrog kws kho mob. Ua tshuaj tua kabmob ASA, nws raug tso cai rau haus tsis pub ntau tshaj 3 hnub.

Tshuaj lom neeg lub zog ntawm cov tshuaj

Thaum ASA crystallizes, koob tsis muaj kob los yog monoclinic polyhedra nrog saj me ntsis qaub yog tsim. Cov muaju yog ruaj khov nyob rau hauv huab cua qhuav, tab sis nrog nce av noo, lawv maj mam hydrolyze rau salicylic thiab acetic acids.

Cov tshuaj nyob rau hauv nws daim ntawv dawb huv yog crystalline hmoov ntawm cov xim dawb thiab ua ntxhiab tsw. Cov tsos ntawm tsis hnov ​​tsw ntawm acetic acid yog qhov taw qhia tias cov tshuaj pib hydrolyze.

kis mob , vim tias qhov kev sib koom ua ke no tuaj yeem ua rau kev txhim kho kev mob tuag taus rau tus menyuam - Reye's syndrome.

Hauv cov menyuam mos yug tshiab, salicylic acid tuaj yeem txav vim albumin bilirubin thiab txhawb kev tsim kho txha caj qaum.

ASA nkag mus yooj yim rau txhua lub cev ntawm lub cev thiab cov nqaij, nrog rau cerebrospinal, synovial thiab peritoneal kua.

Nyob rau hauv qhov muaj edema thiab o, qhov nkag ntawm salicylate rau hauv kev sib koom ua ke tau nrawm. Hauv theem ntawm kev mob, ntawm qhov tsis sib xws, nws ua rau qeeb.

Acetylsalicylic acid thiab cawv

Cawv thaum lub sij hawm ASA yog contraindicated. Xws li kev sib xyaw ua ke yuav ua rau mob plab thiab plab hnyuv qhov muag, nrog rau kev tsis haum tshuaj lom.

Dab tsi yog acetylsalicylic acid rau lub plhaw?

ASA yog ib qho tshuaj zoo rau kev kho mob tsis zoo, vim tias muaj cov tshuaj antiplatelet zoo.

Txawm li cas los xij, nws yuav tsum nco ntsoov tias kev noj cov ntsiav tshuaj zoo dua tsis haus cawv, tab sis txog 2 teev ua ntej noj mov. Qhov no txo ​​txoj kev pheej hmoo ntawm kev kawm. microthrombi hauv cov hlab ntsha me me ntawm lub paj hlwb thiab - hauv ib feem - ntaub so ntswg edema.

Siv thaum cev xeeb tub thiab pub niam mis

Acetylsalicylic acid yog sib kis thaum cev xeeb tub. Tshwj xeeb hauv thawj peb thiab peb lub hlis ntawm kev ua kom tes taw. Hauv cov theem thaum ntxov, kev noj cov tshuaj tuaj yeem ua rau muaj kev pheej hmoo ntawm kev pheej hmoo tsis zoo thaum yug menyuam, hauv theem tom ntej - hla kev xeeb tub thiab kev ua haujlwm tsis muaj zog.

ASA thiab nws cov metabolites hauv cov khoom me me txeem rau hauv cov mis. Tom qab kev tswj hwm kev siv tshuaj yaj yeeb, kev mob tshwm sim tsis pom hauv cov menyuam mos, yog li ntawd, raws li txoj cai, cuam tshuam ntawm kev pub niam mis (HB) tsis tsim nyog.

Yog tias tus poj niam pom tias kho mob ntev ntev nrog kev siv tshuaj ntau ntawm ASA, nws yog qhov tsim nyog yuav tsum txiav tawm HB.

Cov lus qhia rau kev siv:

Acetylsalicylic acid yog cov tshuaj uas muaj kev tiv thaiv kev tiv thaiv, antipyretic, analgesic thiab antiaggregant (txo platelet adhesion) cov nyhuv.

Pharmacological kev txiav txim

Tus txheej txheem ntawm kev ua ntawm acetylsalicylic acid yog vim nws muaj peev xwm los inhibit qhov synthesis ntawm prostaglandins, uas ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov txheej txheem mob, kub cev thiab mob.

Ib qho kev txo qis ntawm prostaglandins nyob rau hauv nruab nrab ntawm thermoregulation ua rau vasodilation thiab nce ntxiv hauv kev tawm hws, uas ua rau cov nyhuv antipyretic ntawm cov tshuaj. Tsis tas li ntawd, kev siv cov tshuaj acetylsalicylic acid tuaj yeem txo qhov rhiab ntawm qhov kawg ntawm cov leeg mob rau cov neeg sib kho mob los ntawm kev txo cov nyhuv ntawm prostaglandins rau lawv. Thaum noj, qhov siab tshaj plaws ntawm acetylsalicylic acid nyob rau hauv cov ntshav tuaj yeem pom tom qab 10-20 feeb, thiab tsim tau los ntawm salicylate metabolism tom qab 0.3-2 teev. Acetylsalicylic acid yog tawm los ntawm lub raum, ib nrab-lub neej yog 20 feeb, ib nrab lub neej rau salicylate yog 2 teev.

Kev qhia rau kev siv cov tshuaj acetylsalicylic acid

Acetylsalicylic acid, kev qhia rau vim yog vim nws cov khoom, tau sau tseg rau:

• mob rheumatic mob, mob pericarditis (mob rau cov leeg ntshav ntawm lub plawv), mob caj dab (mob puas rau cov ntaub so ntswg thiab cov hlab ntsha me me), mob rwj mob (ib qho tshwm sim los ntawm kev mob plab tsis tuaj yeem), Dressler's syndrome (kev sib txuas ntawm pericarditis nrog pleural mob lossis mob ntsws),
• cov tsos mob mob sib khuav ntawm qhov mob sib khuav xwb xws li mob taub hau: mob taub hau, mob taub hau, mob hniav, mob lub cev ntas, mob pob txha, mob leeg, neuralgia, mob hauv pob qij txha, leeg nqaij,
• kab mob ntawm caj qaum nrog mob: sciatica, lumbago, osteochondrosis,
• febrile mob
• qhov xav tau thev taus mus rau cov tshuaj tiv thaiv kev kho mob hauv cov neeg mob uas muaj "aspirin triad" (kev sib xyaw ntawm tus mob ntsws asthma, lub qhov ntswg ua pa thiab tsis haum rau acetylsalicylic acid) lossis "aspirin" hawb pob,
• kev tiv thaiv ntawm myocardial infarction hauv kev mob plawv los yog kev tiv thaiv mob rov qab los,
• muaj cov kev pheej hmoo txaus rau tsis hnov ​​mob myocardial ischemia, mob plawv ua haujlwm, tsis khov lub siab,
• prophylaxis ntawm thromboembolism (clogging ntawm lub nkoj nrog lub nrawm), mitral valve valvular mob plawv, mitral valve prolapse (ua tsis tiav), atrial fibrillation (poob ntawm lub peev xwm los ntawm cov leeg nqaij ntawm cov atria ua haujlwm synchronously),,
• mob thuv mob rau hauv lub plawv (mob rau cov hlab ntshav hlab ntshav thiab tsim kom muaj cov ntshav muaj ntshav thaiv tsis tau cov ntshav tawm hauv lub cev), mob ntsws ntsig (mob ntsws txoj hlab uas cuam tshuam rau lub ntsws), mob ntsws ntsig.

Cov lus qhia rau kev siv cov tshuaj acetylsalicylic acid

Acetylsalicylic acid ntsiav tshuaj yog npaj rau kev siv qhov ncauj, nws raug nquahu kom noj tom qab noj mov nrog mis nyuj, ib txwm dej los yog alkaline ntxhia dej.

Rau cov neeg laus, cov tshuaj acetylsalicylic acid tau pom zoo kom siv 3-4 ntsiav tshuaj hauv ib hnub, 3-4 ntsiav tshuaj (500-1000 mg), nrog rau qhov siab tshaj plaws txhua hnub ntawm 6 ntsiav tshuaj (3 g). Qhov siab tshaj plaws ntawm kev siv acetylsalicylic acid yog 14 hnub.

Txhawm rau txhim kho rheological yam ntxwv ntawm cov ntshav, nrog rau cov tshuaj tiv thaiv ntawm platelet adhesion, ½ ntsiav tshuaj ntawm acetylsalicylic acid ib hnub yog tshuaj rau ob peb lub hlis. Nrog myocardial infarction thiab rau kev tiv thaiv ntawm cov myocardial infarction theem nrab, cov lus qhia rau acetylsalicylic acid pom zoo kom noj tshuaj 250 mg ib hnub. Kev cuam tshuam uas tsis sib xws ntawm lub hlwb thiab lub hlwb ntawm lub hlwb txaus kom pom tseeb tias kev noj tshuaj acet ntsiav tshuaj ntawm acetylsalicylic acid nrog kev kho me ntsis ntawm cov koob tshuaj rau 2 ntsiav tshuaj hauv ib hnub.

Acetylsalicylic acid yog tsim rau cov menyuam yaus hauv cov koob tshuaj hauv qab no: laus dua 2 xyoos - 100 mg, 3 xyoos lub neej - 150 mg, plaub-xyoo - 200 mg, laus dua 5 xyoos - 250 mg. Nws raug nquahu kom menyuam yaus siv tshuaj acetylsalicylic acid 3-4 zaug hauv ib hnub.

Zoo sib xws ntawm Aspirin thiab Acetylsalicylic Acid Formulations

Kev nquag siv rau hauv kev npaj ob leeg yog acetylsalicylic acid (salicylic acetic acid ester) ntawm ntau npaum li 500 mg / 1 tab. Raws li cov tshuaj pharmacological, nws tau raug xa mus ua qhov tsis yog-xaiv cov tsis-tshuaj steroidal.

Kev ua ntawm cov tshuaj yog raws li kev sib xyaw ua ke ntawm 2 hom cyclooxygenases (hom 1 thiab 2). Kev txo qis hauv lub cev kub thiab nyem ntawm qhov mob (sib koom ua ke, mob nqaij thiab mob taub hau) thaum mob febrile muaj feem xyuam nrog kev cuam tshuam ntawm COX-2 synthesis. COX-1 koom rau hauv kev tsim cov prostaglandins, yog li ntawd, kev tsuj tawm ntawm nws cov khoom cua ua rau cov kev mob tshwm sim cuam tshuam nrog kev cuam tshuam cov nqaij mos cytoprotection. Tab sis tib lub sijhawm acetylsalicylic acid inhibits kev coj ua ntawm thrombooxygenase.

Qhov qhia tau rau kev siv tshuaj Aspirin (lossis ASA) yog kev tiv thaiv kev mob ntsws nqaj hlau thiab embolism, nyob rau hauv uas muaj qhov txo qis ntawm myocardial infarction thiab ischemic stroke.

Txo txoj kev mob ntawm cov neeg mob uas muaj ntshav sib txawv thaum noj ASA kuj tshwm sim txuas nrog kev cuam tshuam ntawm kev sib txuas ntawm thromboxanes thiab tshem tawm ntawm ib qho ntawm cov ua rau cov hlab ntsha txhab ntshav - cov ntshav tuab (nce nws viscosity thiab nyiam ua cov ntshav txhaws).

Dosage ntawm cov tshuaj

Txoj cai rau noj Aspirin thiab Acetylsalicylic acid yog qhov qub, nws nyob ntawm qhov ntsuas tseem ceeb rau kev siv, nrog rau cov yam ntxwv ntawm tib neeg kev noj qab haus huv. Txhua tus kws tshaj lij yuav lees paub tias kev siv tshuaj ntau npaum li cas yog ib tus neeg.Txawm li cas los xij, hauv kev siv tshuaj nws yog kev coj los siv ntau txoj hauv kev:

1. Txhawm rau tshem tawm qhov mob siab ntsws mob hauv cov laus (laus dua 15 xyoos), ib ntsiav tshuaj (500 lossis 1000 mg) yog siv. Lub sijhawm nruab nrab ntawm cov koob tshuaj yuav tsum yog tsawg kawg 4 teev, thiab chav kawm kav tsis pub dhau 5 hnub.
2. Yog tias ib tus neeg xav tau kom txo qis kub taub hau, tom qab ntawd cov tshuaj raug kho kom txog 3 hnub. Txhawm rau kom ua tiav qhov xav tau, cov tshuaj ntxuav nrog dej kom ntau.
3. Txog kev tiv thaiv cov kab mob plawv thiab cov kab mob sib kis, ib lub ntsiav tshuaj tau sau tshuaj rau ib hnub lossis txhua lwm hnub. Lub sijhawm kawm kom raug txiav txim los ntawm tus kws khomob tuaj koom.

Cov kws kho mob pom zoo kom noj cov tshuaj tom qab noj mov. Qhov no tso cai rau cov tshuaj nquag yuav tsum tau nqus thiab muaj cov tshuaj ua kom zoo, tsis muaj kev ua rau lub plab zom mov. Nws yog qhov tsis tsim nyog yuav tshuaj los ntawm cov tshuaj rau koj tus kheej;

Kev Sib piv Cov Tshuaj

Cov tshuaj aspirin lossis acetylsalicylic acid, uas yog qhov zoo dua? Nws tsis muaj peev xwm nrhiav tau cov lus teb meej rau lo lus nug no. Hauv cov ntsiab lus, cov tshuaj sib txawv tsuas yog hauv daim ntawv ntawm kev tso tawm thiab ntau npaum li cas ntawm cov tshuaj yeeb yam tseem ceeb.

Cov tshuaj muaj ntsis zoo ib yam hauv kev sib xyaw, qhov qhia tau rau kev siv cov tshuaj aspirin thiab acetylsalicylic yog qhov qub, uas ua rau cov tshuaj sib hloov tau. Lub ntsiab sib txawv ntawm cov tshuaj yog tus nqi, uas nyob ntawm tus tsim khoom lag luam, ntau npaum li cas ntawm cov kua qaub rau hauv cov ntsiav tshuaj thiab daim ntawv tso tawm. Acetylsalicylic acid, raws li txoj cai, yog muag me ntsis pheej yig dua li cov tshuaj zoo sib xws li Aspirin.

Yog tias ib tus neeg pom tsis tau txais txiaj ntsig hauv cov tshuaj Aspirin, ces noj tshuaj Acetylsalicylic acid kuj tseem cuam tshuam rau nws. Txawm li cas los xij, cov khw muag tshuaj niaj hnub muaj ntau ntawm cov qauv tshuaj tiv thaiv, uas nyob hauv lawv lub zog tuaj yeem hloov qhov kev txiav txim ntawm salicylic acid.

Cov cim ntawm "Aspirin" thiab acetylsalicylic acid:

1. Citramon
2. "Paracetamol".
3. "Egithromb" (zoo heev dua li lwm cov analogues hauv cov nqi).
4. Movalis (zoo ib yam li nqi rau Egithromb).

Hauv nruab nrab, tus nqi ntawm Aspirin txawv ntawm 70 rubles rau 500 rubles.

Nthuav txhawb ntxiv

Cov kws tshaj lij pom zoo kom ua raws li qee cov kev cai uas yuav tiv thaiv lub cev kom ntau li ntau tau, tsis tas txo qhov ua tau zoo ntawm cov tshuaj:

1. Yog tias cov ntsiav tshuaj yog yav tas los tsoo, ces nws qhov kev txiav txim yuav ua kom nrawm dua.
2. Nws yog ib qho tseem ceeb los tiv thaiv lub plab hnyuv los ntawm kev ua ntawm acetylsalicylic acid. Cov ntsiav tshuaj tsuas noj tom qab noj mov.
3. Nco ntsoov kom nce los ntshav, uas txwv kev siv tshuaj Aspirin ua ntej kev phais mob, txawm tias ua ntej mus ntsib kws kho hniav. Cov tshuaj tsis suav los ntawm kev siv lub lis piam ua ntej kev phais mob.
4. Cov tshuaj zoo heev txo cov kev zam ntawm uric acid, uas tseem tseem ceeb rau kev txiav txim siab nrog tus neeg muaj mob.

Kev ua raws nraim nrog kws kho mob cov lus pom zoo yuav pab kom tsis txhob muaj qhov ua tsis zoo rau hauv lub cev, tsis tas txo cov txiaj ntsig ntawm kev siv tshuaj.

Cov Ntaub Ntawv Ntxiv

Raws li cov lus qhia, acetylsalicylic acid tsis tuaj yeem khaws cia rau hauv qhov chaw uas qhov cua kub yuav nce siab tshaj 25 ° C. Hauv qhov chaw qhuav thiab nyob ntawm chav sov, cov tshuaj yuav haum rau 4 xyoos.

Cov tshuaj kho mob uas nrov tshaj plaws, tshuaj aspirin, ua lub npe nrov tsaug rau cov neeg ua haujlwm ntawm Bayer lub chaw tsim tshuaj, uas nyob rau xyoo 1893 tau tsim lub thev naus laus zis rau kev tsim cov tshuaj no. Lub npe lag luam "Aspirin" tau tsim los ntawm cov tsiaj ntawv "A" (acetyl) thiab "Spiraea" - cov npe ntawm cov meadowsweet cog hauv Latin. Cov tshuaj yeeb tshuaj nquag, acetylsalicylic acid, tau muab cais tawm los ntawm cov khoom siv cog no.

Cov tshuaj uas nrov tshaj plaws, tshuaj aspirin, tau dhau los ua tsaug rau lub tuam txhab Bayer pharmaceutical.

Aspirin Khoom Muag

Hauv cov tshuaj, cov tawv ntoo willow yog nto moo los ua cov cuab yeej zoo uas pab txo qhov kub.Txawm li cas los xij, cov tshuaj raws li nws coj mus rau qhov tsis zoo tsis txaus siab, uas tau ua pov thawj lawv tus kheej hauv qhov tsis xis nyob thiab tsis hnov ​​mob hauv qhov mob plab.

Acetylsalicylic acid (ASA) - lwm lub npe rau Aspirin - tau pib ua ntej los ntawm cov tawv ntoo willow hauv lub xyoo pua puv 19. Los ntawm nruab nrab ntawm lub xyoo pua, cov kua tshuaj ntawm cov tshuaj salicylic acid tau pom. Thawj thawj zaug, ASK cov qauv uas tau haum rau kev siv tshuaj kho mob tau txais los ntawm Bayer cov neeg ua haujlwm. Lub tuam txhab no tau pib muag cov tshuaj nyob rau hauv cov lag luam tshuaj uas tsis muaj tshuaj npe.

Ib me ntsis tom qab, lwm lub tuam txhab tseem tau txais txoj cai muag tshuaj, uas tau tso cai rau cov tshuaj mus rau tom qab txee ntawm txhua lub tsev muag tshuaj.

Acetylsalicylic acid, los yog Acidum acetylsalicylicum (Latin lub npe Aspirin), tsuas yog cov tshuaj nyob rau lub sijhawm ntawd uas zwm rau pawg ntawm cov tshuaj tsis-steroidal uas muaj cov tshuaj tiv thaiv. Cov tshuaj yog qhov tshwm sim hauv kev siv tshuaj. Nrog nws cov kev pab, tus naj npawb ntawm cov neeg tuag los ntawm kub taub hau poob zoo heev, thiab tom qab Aspirin lub peev xwm los tiv thaiv cov ntshav txhaws hauv cov hlab ntshav tau nrhiav tau, tib neeg tau txais txoj cai los nyob lub neej zoo tom qab muaj kev mob plawv nres, mob hlab ntsha tawg, thiab lwm yam.

Acetylsalicylic acid (lub npe thib ob yog Aspirin) muaj cov cim tshwj xeeb. Hauv xyoo 70, nws tau tshaj tawm tias nws muaj peev xwm txwv kev ua haujlwm ntawm prostogladins. Vim tias muaj cov cuab yeej no, Cov tshuaj aspirin tshem tawm cov mob o vim muaj cov nyhuv hauv cov txheej txheem tshwm sim hauv nws qhov kev tsom.

Qhov ua kom loog thiab tshem tawm qhov kub kub yog vim qhov ua kom tsis txhob muaj thaj chaw ntawm lub hlwb uas ua lub luag haujlwm rau qhov hnov ​​mob thiab thermoregulation.

Lwm qhov taw qhia rau kev siv yog nce siab intracranial siab thiab mob hauv lub taub hau. Nrog rau kev tswj hwm kev noj qab haus huv ntawm cov tshuaj aspirin, cov ntshav ua cov leeg, thiab cov khoob hauv cov hlab ntsha loj dua, uas txwv tsis pub txhim kho lub plawv nres, mob ntshav npleem hauv cov neeg mob uas muaj lub cev ua ntshav txhaws.

Acetic acid salicylic ester (raws li Aspirin hu ua lwm txoj kev) yog dav siv nyob rau hauv lub neej txhua hnub. Ib ntsiav tshuaj yuav daws tau qhov mob zoo tom qab lom cawv. Tshwj xeeb rau qhov no, koj yuav tsum tau yuav cov tshuaj Alka-Seltzer lossis Aspirin UPSA (lub npe ntawm cov tshuaj rau lub hangover, uas muaj acetylsalicylic acid).

Nws yog tsim nyog pom tias, raws li kev tshawb nrhiav los ntawm Oxford University, kev siv tshuaj tua kab mob ntawm Aspirin yuav txo qhov kev pheej hmoo ntawm kev txhim kho oncology nyob rau hauv lub qog plab, prostate, esophagus, ntsws thiab caj pas.

Nws yog qhov ua tau los siv cov tshuaj acetylsalicylic acid (tshuaj aspirin) ntawm nws tus kheej, thiab hauv kev sib xyaw nrog lwm cov tshuaj. Niaj hnub no, muaj ntau cov nyiaj nyob rau hauv uas nws tau muaj - Citramon, Askofen, Asfen, Coficil, Acelisin. Siv cov tshuaj no ib leeg thiab ua ke nrog lwm cov tshuaj.

Tshuaj aspirin rau khaub thuas

Cov tshuaj aspirin, lossis acetylsalicylic acid, yog ib cov tshuaj uas cuam tshuam sai sai txawm tias kev mob hnyav heev ntawm ntau yam keeb kwm thiab cuam tshuam loj heev rau kev ua kom pom tseeb. Ntxiv rau cov yam ntxwv no, cov tshuaj no feem ntau tau tsim los ua rau cov ntshav tuab rau cov neeg uas muaj ntshav txhaws nyob rau hauv cov hlab ntshav. Tshuaj aspirin rau khaub thuas kuj tseem siv, vim tias nws muaj peev xwm tshem tawm qhov kub taub hau, sai txo qhov ntsuas kub.

Nyob rau hauv dab tsi ntau npaum li cas acetylsalicylic acid yuav tsum tau siv rau tus mob khaub thuas, muaj ntau yam contraindications rau siv, peb kawm ntxiv.

Pom yuam kev lawm? Xaiv nws thiab nias Ctrl + Enter

• Cov tshuaj "Aspirin" yog dabtsi
• Yuav haus li cas
• Yam tshuaj twg tuaj yeem noj rau qhov kub taub hau
• Dab tsi yog hemorrhaging tus neeg sawv cev

Kev pab Acid

Tsis yog txhua tus paub hais tias cov tshuaj tseem ceeb ntawm cov tshuaj no yog salicylic acid, zais los ntawm tsob ntoo tshwj xeeb hu ua siprea, uas yog qhov tseeb piav qhia qhov tshwm sim ntawm lub npe tsis zoo "Aspirin".Ib qho khoom sib thooj no kuj muaj nyob hauv ntau lwm cov nroj tsuag, xws li pear, jasmine lossis willow, uas tau nquag siv rau hauv tebchaws Iziv puag thaum ub thiab tau piav los ntawm cov tshuaj muaj zog los ntawm Hippocrates lawv tus kheej.

Kho nyhuv

Tom qab noj cov tshuaj acetylsalicylic acid rau hauv lub cev, hyperemia txo qis, permeability ntawm capillaries ntawm qhov chaw ntawm o cuam tshuam txo qis - tag nrho cov no ua rau muaj qhov pom tseeb analgesic thiab anti-inflammatory. Cov tshuaj sai sai nkag mus rau hauv tag nrho cov ntaub so ntswg thiab dej, kev nqus tshwm sim hauv cov hnyuv thiab nplooj siab.

Cov kev ua ntawm acetylsalicylic acid:

• muab cov txiaj ntsig los tiv thaiv tsis tu ncua 24–48 teev tom qab pib noj tshuaj,
• tshem tawm mob me mus rau mob me,
• txo qhov siab tshaj plaws ntawm lub cev kub, thaum tsis cuam tshuam rau kev ua tau zoo,
• acetylsalicylic acid ua kom cov ntshav txhaws, cuam tshuam txog platelet sib xyaw - lub nra rau lub plawv cov nqaij pob txha tsawg, kev pheej hmoo ntawm lub plawv txo qis.

Cov tshuaj tuaj yeem coj los tiv thaiv kev mob thrombosis, mob txhaws, txo kev pheej hmoo ntawm cov hlab ntsha hauv lub hlwb.

Ua tib zoo mloog! Cov nyhuv antiplatelet ntawm ASA raug pom nyob hauv 7 hnub tom qab siv ib zaug tshuaj. Yog li, cov tshuaj tsis tuaj yeem quav ua ntej kev phais mob, ua ntej kev coj khaub ncaws.

Nquag noj tshuaj acetylsalicylic acid inhibits (tiv thaiv) kev tsim cov ntshav txhaws (ntshav txhaws), uas tuaj yeem thaiv lumen ntawm cov leeg ntshav. Qhov no yuav luag halves qhov pheej hmoo ntawm lub plawv nres.

Vim nws qhov kev pom dav dav ntawm kev nqis tes ua, acetylsalicylic acid yog siv rau kev kho mob thiab tiv thaiv cov kab mob ntawm ntau yam etiologies rau cov laus thiab cov menyuam hnub nyoog 15 xyoos.

Dab tsi pab acetylsalicylic acid:

• febrile tej yam kev mob uas nrog pathologies ntawm ib tug kis thiab mob qhov,
• rheumatism, mob caj dab, mob pericarditis,
• mob taub hau, mob hniav, mob leeg, sib koom tes, coj khaub ncaws, mob leeg neuralgia,
• kev tiv thaiv ntawm lub plawv nres, mob stroke nrog cov teeb meem circulatory, nce ntshav viscosity,
• kev tiv thaiv ntawm cov ntshav txhaws nrog kev tshuaj ntsuam genetic predisposition kom mob thrombophlebitis,
• tsis ruaj khov angina pectoris.

ASAs muaj nyob hauv txoj hauv kev kho mob nyuaj hauv kev kho mob ntsws, pleurisy, osteochondrosis, lumbago, lub plawv tsis zoo, mitral valve prolapse. Cov tshuaj no raug pom zoo kom siv thaum thawj cov tsos mob khaub thuas, mob khaub thuas tshwm sim - nws pab txhawb kev tawm hws, uas ua rau muaj kev txhim kho sai ntawm tus mob.

Tswv yim! Cov tshuaj aspirin yog ib txoj kev kho mob zoo tshaj plaws rau kev tshem tawm cov kev mob tshwm sim ntawm lub haus dej cawv; cov tshuaj yaj tau ua kom ntshav txhaws, tshem tawm mob taub hau thiab o, thiab txo cov mob siab intracranial.

Acetylsalicylic acid rau mob taub hau yog nrov npe hu ua tshuaj aspirin los yog tshuaj ntsiav rau lub taub hau. Nws yog cov tshuaj tiv thaiv thiab tawm tsam.

Puas yog nws muaj peev xwm noj cov tshuaj aspirin rau kev xeeb tub thiab lactating poj niam, menyuam

Acetylsalicylic acid yog sib kis hauv cov menyuam yaus hnub nyoog qis dua 14 xyoos, txij li thaum cov tshuaj muaj peev xwm tshem tawm cov bilirubin, uas tuaj yeem ua rau mob encephalopathy hauv cov menyuam mos, mob raum thiab mob hlwb ntau yam hauv cov menyuam yaus preschool thiab cov hluas. Kev siv tshuaj rau menyuam yaus - 250 mg ob zaug ib hnub, qhov ntau tshaj tso cai tau siv txhua hnub yog 750 mg.

Acetylsalicylic acid yog raug txwv tsis pub siv thaum cev xeeb tub hauv thawj peb lub hlis - cov tshuaj muaj teratogenic nyhuv, tuaj yeem ua rau muaj kev loj hlob ntawm lub plawv tsis zoo hauv cov menyuam, cais tawm ntawm lub ntsej muag sab saud.

Ua tib zoo mloog! ASA ntau zaus ua rau muaj menyuam nchuav menyuam thaum ntxov.

Nws yog tsis yooj yim sua kom noj cov tshuaj acetylsalicylic acid, paracetamol txawm tias nyob rau xyoo III lub sijhawm - cov tshuaj ua rau kev mob ntshav hauv lub cev, uas ua rau kev txhim kho ntawm pathologies hauv cov hlab cua, ua rau cov ntshav khiav tsis zoo.Siv ASA rau lub sijhawm no tuaj yeem ua rau kev mob ntshav rau uterine heev.

Thaum pub niam mis, koj tsis tuaj yeem noj tshuaj ASA, vim tias cov kua qaub nkag rau hauv cov mis, uas tuaj yeem ua rau tus menyuam tsis zoo, kev loj hlob ntawm kev fab tshuaj tsis haum.

Hauv txoj haujlwm ntawm lub hlis thib ob, kev nkag mus yog qhov ua tau, tab sis tsuas yog tias muaj qhov pom tseeb thiab nrog kev tso cai los ntawm tus kws kho mob, kev nkag mus kiag hauv lub sijhawm kawg ntawm kev xeeb tub

Cov lus qhia rau kev siv cov tshuaj acetylsalicylic acid

ASA yuav tsum noj tsuas yog tom qab noj mov, thiaj li kom tsis txhob ua rau lub cev tsis zoo hauv lub plab zom mov, koj tuaj yeem haus nws nrog dej tsis muaj roj lossis mis nyuj. Tus txheej txheem tshuaj yog 1-2 ntsiav tshuaj 2-4 zaug hauv ib hnub, tab sis tsis ntau tshaj 1000 mg rau ib zaug. Koj tuaj yeem haus tsis pub ntau tshaj 6 ntsiav tshuaj hauv ib hnub.

Yuav ua li cas coj ASA rau qee qhov pathologies:

1. Rau kev ua kom ntshav, ua ib qho tiv thaiv tawm tsam lub plawv - 250 mg ib hnub rau 2-3 lub hlis. Thaum muaj xwm ceev, qhov nce ntxiv txog li 750 mg tau tso cai.
2. Acetylsalicylic acid los ntawm mob taub hau - nws txaus los noj 250-500 mg ntawm ASA, yog tias tsim nyog, koj tuaj yeem rov qab noj dua tom qab 4-5 teev.
3. Nrog mob khaub thuas, mob khaub thuas, los ntawm qhov kub thiab txias, mob hniav - 500-1000 mg ntawm cov tshuaj txhua 4 teev, tab sis tsis pub tshaj 6 ntsiav tshuaj ib hnub.
4. Txhawm rau tshem tawm qhov mob thaum coj khaub ncaws - haus 250-500 mg ntawm ASA, yog tias tsim nyog, rov hais dua tom qab 8-10 teev.

Tswv yim! Haus dej haus tshuaj aspirin nrog me ntsis ntawm txoj kev hloov hauv lub plawv, yog tias tsis muaj cov tshuaj antihypertensive ntawm tes.

Keeb kwm me ntsis

Acetylsalicylic acid tau pom thawj zaug hauv xyoo pua puv 19 los ntawm cov tub ntxhais hluas kws tshuaj lom neeg Felix Hoffman, uas yog lub sijhawm ntawd ua haujlwm ntawm Bayer. Nws yeej xav txhim kho lub cuab yeej uas tuaj yeem pab nws txiv txo cov mob ua ke. Lub tswv yim ntawm qhov twg mus nrhiav qhov muaj pes tsawg leeg xav tau, nws raug kev tshoov siab los ntawm nws txiv tus kws kho mob. Nws tau sau cov tshuaj sodium salicylate rau nws tus neeg mob, tab sis tus neeg mob tsis tuaj yeem noj, vim tias nws ua kom mob plab hnyuv tawm.

Tom qab ob xyoos, ib qho tshuaj xws li Aspirin tau txais daim ntawv tso cai hauv Berlin, yog li acetylsalicylic acid yog tshuaj aspirin. Qhov no yog lub npe luv: tus sau ua ntej "a" yog ib pab pawg neeg acetyl uas tau txuas rau salicylic acid, lub hauv paus “spir” qhia tias spiric acid (hom kua qaub no muaj nyob rau hauv daim ntawv ntawm ether hauv cov nroj tsuag, ib qho yog spirea), thiab qhov kawg yog “hauv” Hauv cov hnub ntawd, feem ntau siv cov npe tshuaj.

Tshuaj aspirin: tshuaj lom neeg

Nws hloov tawm tias Acetylsalicylic acid yog Aspirin, thiab nws cov molecule muaj ob hom kua qaub: salicylic thiab acetic. Yog tias koj khaws cov tshuaj nyob rau hauv chav tsev kub, tom qab ntawd thaum qhov chaw siab siab nws sai sai ua rau ob lub tebchaw acid.

Vim li ntawd cov lus sib xyaw ntawm "Aspirin" yeej ib txwm muaj cov acetic thiab salicylic acids, tom qab lub sijhawm luv luv lub sijhawm tseem ceeb tau ua me me. Lub txee lub neej ntawm cov tshuaj nyob ntawm qhov no.

Noj tshuaj

Tom qab cov tshuaj aspirin nkag mus rau hauv lub plab, thiab tom qab ntawd mus rau hauv duodenum, cov kua txiv los ntawm lub plab tsis ua rau nws, txij li cov kua qaub ua kom zoo tshaj plaws hauv ib qho chaw alkaline. Tom qab duodenum, nws yog nqus rau hauv cov ntshav, thiab tsuas yog muaj nws hloov pauv, salicylic acid tau tso tawm. Thaum cov tshuaj nce mus rau lub siab, qhov ntau ntawm cov acids txo, tab sis lawv cov dej-soluble derivatives ua ntau dua.

Thiab twb dhau los ntawm cov hlab ntsha ntawm lub cev, lawv mus txog rau lub raum, los ntawm qhov chaw uas lawv tau ua ke nrog zis. Ntawm cov zis ntawm Aspirin tseem tshuav ib qho kev ntsuas tsis zoo - 0.5%, thiab tus nqi ntxiv yog cov khoom noj. Nws yog lawv uas yog tus muaj pes tsawg leeg kho. Kuv tseem xav hais tias cov tshuaj muaj 4 yam tshuaj kho tau:

• Kev tiv thaiv cov ntshav txhaws.
• Sau lub zog.
• Antipyretic nyhuv.
• Txo qhov mob.

Acetylsalicylic acid muaj qhov ua haujlwm loj, qhov kev qhia muaj cov lus qhia ntxaws ntxaws rau kev siv. Nco ntsoov koj paub nws tus kheej lossis sab laj nrog kws kho mob.

Tshuaj aspirin: daim ntawv thov

Peb pom tawm yuav ua li cas acetylsalicylic acid ua haujlwm. Los ntawm qhov nws pab, peb yuav nkag siab ntxiv.

1. Thov rau qhov mob.
2. Thaum siab kub.
3. Nrog rau ntau yam sib kis.
4. Hauv kev kho thiab tiv thaiv mob pob txha.
5. Rau kev tiv thaiv ntawm thrombosis.
6. Tiv thaiv kom txhob mob stroke thiab lub plawv nres.

Cov tshuaj zoo heev yog acetylsalicylic acid, tus nqi rau nws kuj yuav thov txhua tus neeg, vim tias nws tsawg thiab fluctuates tsis pub dhau rubles nyob ntawm seb cov khw thiab ntau npaum.

Aspirin: kev tawm tsam ntshav txhaws

Cov ntshav txhaws nyob hauv thaj chaw ntawm cov hlab ntshav qhov twg muaj kev puas tsuaj rau phab ntsa. Hauv cov chaw no, cov fibers tau raug rau uas muab cov kabmob sib txuas ua ke. Cov ntshav plasmaets ncua rau ntawm lawv, uas khaws cov khoom uas pab ua kom muaj kev sib ntxiv, thiab hauv cov chaw zoo li no lub nkoj nqaim.

Feem ntau, hauv lub cev noj qab nyob zoo, thromboxane txwv los ntawm lwm qhov - prostacyclin, nws tsis pub platelets los lo ua ke thiab, hloov pauv, dilates cov hlab ntsha. Nyob rau lub sijhawm thaum lub nkoj puas ntsoog, qhov sib npaug ntawm ob qho kev ua haujlwm hloov chaw, thiab prostacyclin tsuas yog tsis kam ua. Thromboxane tsim tawm ntau dhau, thiab cov ntshav ntawm platelets loj tuaj. Yog li, cov ntshav ntws tawm ntawm cov hlab txhua txhua hnub qeeb dua. Yav tom ntej, qhov no tuaj yeem ua rau mob stroke lossis lub plawv nres. Yog tias cov tshuaj acetylsalicylic acid noj tas li (tus nqi ntawm cov tshuaj, raws li tau sau tseg, ntau tshaj tus nqi pheej yig), tom qab ntawd txhua yam hloov pauv.

Cov kua qaub ua rau cov tshuaj aspirin tiv thaiv kev loj hlob sai ntawm thromboxane thiab pab tshem nws ntawm lub cev. Yog li, cov tshuaj tiv thaiv cov hlab ntsha los ntawm cov ntshav txhaws, tab sis nws yuav siv sijhawm tsawg kawg 10 hnub los noj tshuaj, vim tias tsuas yog tom qab lub sijhawm no platelets rov qab muaj peev xwm rov qab ua ke.

"Cov tshuaj aspirin" ua cov tshuaj tua kab mob thiab tshuaj pleev xim

Cov tshuaj no tseem cuam tshuam nrog cov txheej txheem ua haujlwm hauv lub cev, nws txwv tsis pub tso ntshav tawm rau ntawm thaj chaw ntawm mob, nrog rau cov tshuaj uas ua rau mob. Nws muaj lub peev xwm los txhim kho kev tsim cov tshuaj hormone histamine, uas ua kom cov leeg ntshav khov thiab txhim kho cov ntshav txaus rau ntawm qhov chaw ntawm cov txheej txheem inflammatory. Nws kuj tseem pab ntxiv dag zog rau ntawm phab ntsa ntawm cov hlab ntsha nyias nyias. Tag nrho cov no tsim ib qho kev tiv thaiv kev tiv thaiv thiab ua kom loog.

Raws li peb pom, acetylsalicylic acid muaj kev tiv thaiv zoo rau qhov kub thiab txias. Txawm li cas los xij, qhov no tsis yog nws tsuas yog zoo dua. Nws ua tau zoo rau txhua yam kev mob thiab mob tshwm sim hauv tib neeg lub cev. Vim li ntawd cov tshuaj no feem ntau pom nyob hauv tsev cov tshuaj hauv siab.

"Tshuaj aspirin" rau menyuam yaus

Acetylsalicylic acid yog tsim rau cov menyuam yaus thaum muaj qhov kub nce, mob sib kis thiab mob hnyav thiab nrog mob hnyav. Yuav tsum ua tib zoo nrog menyuam yaus hnub nyoog qis dua 14 xyoos. Tab sis rau cov uas muaj hnub nyoog 14 xyoos, koj tuaj yeem noj ib nrab ntsiav tshuaj (250 mg) thaum sawv ntxov thiab yav tsaus ntuj.

"Cov tshuaj aspirin" noj tsuas yog tom qab noj mov, thiab menyuam yaus yuav tsum tau tsoo lub ntsiav tshuaj thiab haus dej kom ntau.

Xaus

Yog li los mus ntsiab lus. Dab tsi pab kom acetylsalicylic acid? Cov tshuaj no pab tiv thaiv kev ua npaws, cov ntshav txhaws, nws yog cov tshuaj tiv thaiv zoo thiab tshuaj tua kab mob.

Txawm hais tias qhov tseeb tias tshuaj muaj mob loj contraindications rau siv, nws cog lus rau lub neej tom ntej. Tam sim no, feem ntau cov kws tshawb fawb tab tom nrhiav rau cov kev pabcuam uas yuav txo cov kev puas tsuaj ntawm cov tshuaj ntawm ib tus kabmob. Kuj tseem muaj lub tswv yim tias lwm cov tshuaj yuav tsis tuaj yeem txav cov tshuaj aspirin, tab sis, ntawm qhov tsis tooj, nws yuav muaj thaj chaw tshiab ntawm kev thov.

Tshuaj aspirin yog qhov txaus ntshai tab sis tus phooj ywg siab

Tej zaum, yog tias koj thov ib qho ntawm peb kom qhia cov npe tshuaj uas nto moo tshaj plaws, txhua tus yuav nco qab cov tshuaj zoo ib yam. Qhov no zoo ntsiav tshuaj nyob rau hauv thaum yau cawm peb ntawm kub taub hau, thiab twb paub tab cov me nyuam ua tsaug rau nws coj rov qab mus rau lub neej cov nyhuv - nyob rau hauv sawv ntxov, tom qab ob tog thiab lwm yam mob ntawm kev ua pob. Qee tus neeg paub tias rau cov neeg laus, cov kws kho mob feem ntau kuj tau sau tshuaj rau qhov tshuaj no - hauv kev siv tshuaj me me, tab sis rau kev siv txhua hnub. Puas muaj cov haujlwm ntau dhau rau ib lub penny nrog tus nqi pheej yig?

Thiab qhov kev kho tau zoo no tseem muaj lub npe tsis zoo - lawv hais tias nws tuaj yeem ua rau mob plab, thiab nws tsis raug pom zoo rau menyuam yaus muab nws txhua. Txhua leej txhua tus nco qab TV tshaj tawm - txog cov ntsiav tshuaj effervescent, uas yog qhov ua tau zoo dua li ib txwm, tab sis nws ntseeg tias nws yog los ntawm lawv tias muaj kev phom sij ntau dua.

Cov tshuaj no zoo li cas? Ntawm chav kawm, tshuaj aspirin.

Aspirin Khoom Muag

Yuav ua li cas ib tug thiab tib lub ntsiav tshuaj pab ua ke nrog kev sib kis kab mob, mob pob txha, mob taub hau thiab mob plawv?

Acetylsalicylic acid yeej muaj cov yam ntxwv tshwj xeeb. Nws muaj peev xwm txwv qhov kev ua si ntawm cyclooxygenase enzymes (COX-1, COX-2, thiab lwm yam), lub luag haujlwm rau cov synthesis ntawm inflammatory mediators - prostaglandins. Raws li qhov tshwm sim ntawm kev ua ntawm cov tshuaj aspirin, lub zog muab ntawm cov txheej txheem o tau tsawg, uas ua rau nws txoj kev paub. Qhov no yog qhov tshwj xeeb tshaj yog muaj xwm txheej qhov mob tsis zoo rau lub cev - piv txwv li, muaj cov mob rheumatic.

Qhov antipyretic thiab analgesic cov teebmeem ntawm cov tshuaj aspirin cuam tshuam nrog kev poob siab rau ntawm qhov chaw ntawm lub hlwb, uas yog lub luag haujlwm rau thermoregulation thiab mob rhiab. Yog li, thaum kub, thaum lub xeev kub taub hau pab tsis tau, tab sis tsuas yog ua kom mob lub cev, nws raug nquahu kom haus cov tshuaj no.

Cov tshuaj aspirin cuam tshuam cov qe ntshav - platelets, nws txo qis lawv lub peev xwm los txhawm rau ua ke thiab ua cov ntshav txhaws. Nrog rau kev siv cov tshuaj tsis tu ncua, cov ntshav "liquefies" me ntsis, thiab cov hlab ntsha ua rau me ntsis, uas txiav txim siab zoo cuam tshuam nrog kev mob siab thiab mob taub hau ntau dua, thiab tseem tuaj yeem pab tiv thaiv kev mob plawv, mob ntshav nce hlwb thiab thromboembolism nyob rau hauv cov neeg mob uas muaj lub siab nyiam ua kom mob ntsws.

Kev tiv thaiv tsis zoo

Hmoov tsis zoo, qhov tsis tseem ceeb ntawm cov tshuaj aspirin kuj muaj qhov laj thawj. Qhov tseeb yog tias kev tsuj ntawm kev ua ntawm cyclooxygenases (cov enzymes) muaj qhov tsis zoo - ib qho ntawm cov enzymes, COX-1, yog lub luag haujlwm rau kev ua haujlwm li qub ntawm cov hlwb ntawm lub plab hnyuv. Nws qhov thaiv ua rau muaj kev ua txhaum ntawm kev ncaj ncees ntawm lub plab phab ntsa thiab yog qhov ua rau txhim kho cov mob txhab.

Thaum qhov kev mob tshwm sim no ntawm cov tshuaj aspirin raug kuaj pom, tus naj npawb ntawm qhov ntsuas rau nws siv tau qee qhov nqaim: raws li cov cai niaj hnub, nws tsis yog cov kws kho rau cov neeg mob rwj. Ntxiv rau, bronchial hawb pob yog qhov ua kom pom tseeb rau kev teem caij acetylsalicylic acid. lub hnub nyoog ntawm cov menyuam yaus hnub nyoog qis dua 12 xyoos nyob rau hauv muaj cov kabmob kis (vim tias ntxim li yuav muaj tus mob Reye's syndrome).

Cov neeg tsim tawm tshuaj aspirin tau sim txo qhov tsis zoo rau lub plab hnyuv los ntawm kev pib tsim cov txheej txheem effervescent ntawm cov ntsiav tshuaj uas yaj rau hauv dej ua ntej siv. Txawm li cas los xij, cov kab ke hauv nruab nrog cev ntawm cov tshuaj tom qab nqus thiab cov teeb meem tsis zoo ntawm cov khoom tseem ceeb ntawm cov ntsiav tshuaj xws li - citric acid - ntawm cov hniav txha hniav laus, qhov zoo ntawm daim ntawv tshiab tau nruab nrab los ntawm nws qhov tsis txaus.

Kev tsim txom ntawm Aspirin

Tab sis tsis muaj laj thawj rau kev cuam tshuam - mus txog hnub no, cov kws muag tshuaj tau kawm cais cov txiaj ntsig ntawm kev cuam tshuam ntawm kev ua si ntawm COX ntawm ntau yam. Cov tshuaj tau tshwm sim rau ntawm kev ua lag luam uas tuaj yeem, tsis muaj teeb meem hauv lub plab, xaiv cov tshuaj tiv thaiv tsuas yog cov enzymes uas ua rau cov txheej txheem mob. Cov tshuaj no tau tsim cov pawg neeg xaiv cov tshuaj COX-2 inhibitors, thiab tam sim no muaj kev lag luam dav nyob hauv ntau cov npe lag luam.

Lwm yam kev cuam tshuam ntawm cov tshuaj aspirin kuj tau coj los ua lub hauv paus rau cov tshuaj tiv thaiv niaj hnub no, tshuaj pleev xim thiab tshuaj tua kab mob antiplatelet. Tab sis acetylsalicylic acid, txawm hais tias ib nrab muab txoj hauv kev rau "ntau tshaj cov xeeb leej xeeb ntxwv," tseem nyob ntawm lub txee ntawm cov khw muag tshuaj thiab hauv lub arsenal ntawm cov tshuaj uas tau sau tseg hauv cov tsev kho mob. Kuv xav hais - hauv kev ua khoom plig, tab sis qhov laj thawj yog ntau dua prosaic - nws tseem yog txoj kev pheej yig tshaj los txo qis kub, daws qhov mob thiab tiv thaiv kev txhim kho ntawm cov kab mob plawv.

Ntau yam, npe thiab cov ntaub ntawv ntawm kev tso tawm Aspirin

1. Ntsiav tshuaj rau kev tswj hwm qhov ncauj,

2. Cov roj ntsha Effervescent rau cov tshuaj nyob hauv dej.

• Cov tshuaj ua kom zoo rau cov tshuaj aspirin 1000 thiab Aspirin Express - 500 mg acetylsalicylic acid,
• Cov tshuaj ntsiav tshuaj muaj txiaj ntsig zoo Aspirin C - 400 mg ntawm acetylsalicylic acid thiab 240 mg ntawm vitamin C,
• Tshuaj aspirin qhov ncauj - 500 mg,
• Tshuaj aspirin Cardio - 100 mg thiab 300 mg.

Cov khoom siv hauv qab no suav nrog ntau hom thiab ntau hom tshuaj Aspirin ua cov tshuaj tiv thaiv:

• Cov tshuaj kho mob ua kom noj qab haus huv Aspirin 1000, Aspirin Express thiab Aspirin C - sodium citrate, sodium carbonate, sodium bicarbonate, citric acid,
• Cov tshuaj hauv qhov ncauj Cov tshuaj aspirin - microcrystalline cellulose, cov hmoov txhuv nplej siab pob kws,
• Cov tshuaj aspirin Cardio - cellulose, pob kws hmoov txhuv, methacrylic acid thiab ethyl acrylate copolymer 1: 1, polysorbate, sodium lauryl sulfate, talc, triethyl citrate.

Cov sib xyaw ua ke ntawm txhua lwm cov lus thiab cov generics, uas kuj txhais tau, hais lub npe "Aspirin", yog kwv yees li ntawm qhov uas tau muab rau saum toj no. Txawm li cas los xij, tib neeg kev txom nyem los ntawm kev phiv tshuaj lossis tsis quav tshuaj rau ib qho tshuaj twg yuav tsum ua tib zoo nyeem cov tshuaj muaj Aspirin qhia rau hauv pob ntawv me me uas txuas nrog rau cov tshuaj.

Aspirin ntsiav tshuaj effervescent thiab rau kev tswj hwm ntawm qhov ncauj - qhia txog kev siv

1. Kev siv cov tsos mob kom zoo rau qhov mob siab ntawm ntau qhov chaw thiab ua rau:

3. Kab mob rheumatic (mob rheumatism, rheumatic chorea, mob rheumatoid, mob caj dab, Myosarditis).

4. Collagenoses (muaj kev loj hlob ntawm cov kab mob sclerosis, scleroderma, kab ke lupus erythematosus, thiab lwm yam).

5. Hauv kev coj ua rau cov neeg ua xua thiab cov kws kho qhov tsis haum tshuaj txhawm rau txo qis qib ntawm cov neeg mob thiab tsim kom muaj kev tiv thaiv tsis haum rau cov neeg mob "aspirin hawb pob" lossis "aspirin triad."

Tshuaj aspirin Cardio - kev qhia siv

• Thawj qhov kev tiv thaiv ntawm myocardial infarction hauv cov neeg uas muaj kev pheej hmoo siab ntawm nws txoj kev loj hlob (piv txwv, muaj ntshav qab zib mellitus, kub siab, ntshav siab cov rog, rog rog, haus luam yeeb, cov neeg laus dua 65),
• Kev Tiv Thaiv ntawm myocardial infarction,
• Kev tiv thaiv mob stroke
• Kev tiv thaiv ntawm kev pheej hmoo cerebrovascular,
• Kev tiv thaiv ntawm thromboembolism tom qab kev phais mob rau cov hlab ntsha (piv txwv li cov hlab ntshav hla kev hla pob txha, leeg ntshav ntawm lub cev, angioplasty, stenting thiab endarterectomy ntawm cov carotid hlab ntsha),
• Kev tiv thaiv ntawm txoj hlab ntsws sib sib zog nqus,
• Kev tiv thaiv ntawm thromboembolism ntawm lub ntsws o thiab nws cov ceg,
• Kev tiv thaiv ntawm thrombosis thiab thromboembolism nrog lub caij ntev raug rau immobility,
• Tsis khov thiab ruaj khov angina,
• Atherosclerotic lesion ntawm cov hlab ntsha txhaws (Kab mob Kawasaki),
• Aortoarteritis (Kab mob Takayasu).

Tshuaj pleev rau lub ntsej muag rau Acne (lub ntsej muag nrog tshuaj aspirin)

• Tu tawv nqaij thiab tshem tawm cov pob dub
• Txo cov rog ua los ntawm cov qog ua tawv nqaij,
• Zawm pores
• Txo txo ​​cov tawv nqaij o,
• Tiv thaiv qhov tsim ntawm pob ntxau thiab ntxau,
• Tshem tawm cov tawv nqaij
• Tshem tawm cov cim pob txuv
• Exfoliates tuag rau mob hlwb tuag
• Yuav cov tawv nqaij ua kom zoo ntxiv.

Hauv tsev, txoj kev yooj yim tshaj plaws thiab siv cov tshuaj Aspirin los txhim kho tus qauv ntawm daim tawv nqaij thiab tshem tawm pob txuv yog qhov ncauj qhov ntswg nrog cov tshuaj no.Rau lawv cov kev npaj, koj tuaj yeem siv cov ntsiav tshuaj zoo ib yam uas tsis muaj lub plhaub, yuav hauv khw muag tshuaj. Lub ntsej muag lub ntsej muag nrog tshuaj Aspirin yog ib qho tshuaj me me rau kev pleev tshuaj, yog li nws pom zoo kom ua nws tsis ntau tshaj 2-3 zaug hauv ib lub lis piam, thiab thaum nruab hnub tom qab siv cov txheej txheem pleev, tsis txhob nyob rau hauv tshav ntuj ncaj qha.

1. Rau roj thiab oily tawv. Lub npog ncauj ntxuav cov hws tawm hws, nplig cov tawv nqaij thiab txo qhov mob. Zuaj 4 cov tshuaj aspirin rau hauv cov hmoov thiab muab sib tov nrog ib diav dej, ntxiv me nyuam diav ntawm zib ntab thiab zaub roj (txiv ntseej, paj noob hlis, thiab lwm yam). Thov cov sib tov sib xyaw rau lub ntsej muag thiab zaws hauv 10 feeb, tom qab ntawd yaug nrog dej sov.

2. Rau cov tawv nqaij kom qhuav. Lub npog ncauj txo txoj kev o thiab soothes ntawm daim tawv nqaij. Zom 3 cov tshuaj ua kua ntses Aspirin thiab sib tov nrog tablespoon ntawm yogurt. Tso cov dej tiav rau lub ntsej muag, tawm rau 20 feeb thiab yaug nrog dej sov.

3. Rau cov teeb meem ntawm daim tawv nqaij nrog qhov mob ntau dhau. Lub npog ncauj zoo txo ​​kev txo qis thiab tiv thaiv cov tsos mob ntawm pob txuv tshiab. Txhawm rau npaj lub npog ntsej muag, ntau cov tshuaj Aspirin yog hauv av thiab nchuav nrog dej kom txog thaum lub ntsej muag tuab, uas tau thov cov ntsiab lus rau pob ntxau lossis ntxau thiab tawm mus li 20 feeb, thiab tom qab ntawd ntxuav tawm.

Sab sij huam

1. Lub plab zom mov:

• Mob plab
• Xeev siab
• Ntuav
• Kev mob siab
• Mob hnyuv los ntshav (tso quav dub, ntuav nrog ntshav, muaj ntshav hauv cov quav),
• Los ntshav kev ntshav
• Kev zom zaws thiab mob txhab ntawm lub plab zom mov,
• Ntxiv kev ua haujlwm ntawm daim siab enzymes (AsAT, AlAT, thiab lwm yam).

2. Nruab nrab lub paj hlwb:

• Muaj los ntshav ntau
• Los ntshav ntawm ntau cov chaw (ntswg, gingival, pojniam plab, thiab lwm yam),
• Hemorrhagic purpura,
• Qhov tsim ntawm hematomas.

4. Ua xua:

Cov qauv ntawm Aspirin

• Aspivatrin ntsiav tshuaj effervescent,
• Aspen ntsiav tshuaj thiab effervescent ntsiav tshuaj,
• Tshuaj aspitrin,
• Asprovit effervescent ntsiav tshuaj,
• Tshuaj ntsiav Acetylsalicylic acid,
• Atsbirin effervescent ntsiav tshuaj,
• Ntsiav tshuaj Nekstrim Ceev,
• Ntsiav tshuaj effervescent ntsiav tshuaj,
• Upsarin Upsa effervescent ntsiav tshuaj,
• Fluspirin effervescent ntsiav tshuaj.

Txhais ntawm Aspirin C yog cov tshuaj hauv qab no:

• Cov tshuaj aspivit effervescent,
• Aspen C effervescent ntsiav tshuaj,
• Asprovit C effervescent ntsiav tshuaj,
• Upsarin Upsa muaj ntsiav tshuaj Vitamin C effervescent ntsiav tshuaj.

Txhais cov lus ntawm Aspirin Cardio yog cov tshuaj hauv qab no:

Tshuaj aspirin thiab Aspirin Cardio - nqe

• Tshuaj aspirin C effervescent ntsiav tshuaj 10 daim - 165 - 241 rubles,
• Tshuaj aspirin nthuav qhia 500 mg 12 pieces - 178 - 221 rubles,
• Cov tshuaj aspirin rau cov thawj coj ntawm qhov ncauj, 500 mg 20 pieces - 174 - 229 rubles,
• Tshuaj aspirin Cardio 100 mg 28 ntsiav tshuaj - 127 - 147 rubles,
• Tshuaj aspirin Cardio 100 mg 56 ntsiav tshuaj - 225 - 242 rubles,
• Tshuaj aspirin Cardio 300 mg 20 ntsiav tshuaj - 82 - 90 rubles.

Dab tsi yog qhov sib txawv ntawm ASPIRIN thiab Acetylsallicylic Acid ntsiav tshuaj.

tab sis analgin (metamizole sodium los yog ntsev ntsev (2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino methanesulfonic acid, ib qho tshuaj los ntawm pawg antipyrine) rau txhua qhov no muaj kiag li tsis muaj dab tsi ua! qhov no yog cov tshuaj sib txawv kiag li, kuj yog qhov ua kom loog thiab antipyretic, tab sis nws cov tshuab ntawm kev ua yog txawv kiag li! los ntawm txoj kev, nws twb txwv hauv yuav luag txhua lub tebchaws rau kev tsim khoom thiab muag vim qhov tshwm sim

Tshuaj aspirin yog cov tshuaj uas tsis yog tshuaj steroidal (NSAID). Nws ntseeg tau tias lub npe "Aspirin" yog tsim ua ob ntu: "a" - los ntawm acetyl thiab "spir" - los ntawm Spiraea (raws li cov nroj tsuag meadowsweet hu ua Latin, los ntawm cov kua qaub rau salicylic acid ua ntej sib cais).

Rau ntau tshaj li ib puas xyoo, Aspirin tau siv tshuaj hauv kev kho mob ua tshuaj tua kab mob siab thiab ua kom loog. Ntev npaum li cas peb cia li haus ib ntsiav tshuaj Aspirin ntawm qhov kub thiab qhov mob. Qhov pheej ywg thiab siv tshuaj muaj txiaj ntsig zoo li no pom nyob hauv tsev neeg ntawm txhua tus neeg hauv cov txee tshuaj tom tsev.

Nkaus.Anti-inflammatory, antipyretic thiab analgesic. Cov Khoom Qhia. Rheumatism, mob taub hau, mob hniav, mob myalgia, neuralgia, kub taub hau, mob thrombophlebitis, kev tiv thaiv ntawm myocardial infarction. Txoj kev ntawm kev coj thiab ntau npaum. Cov tshuaj yog coj qhov ncauj tom qab noj mov. Cov ntsiav tshuaj yog phua thiab ntxuav nrog ntau cov kua, nyiam mis. Cov neeg muaj hnub nyoog tau raug xaj 0.3-1 g ib koob kom txog ntau kawg koob txhua hnub ntawm 4 g Cov menyuam yaus hauv koob tshuaj txhua hnub nyob rau hnub nyoog: txog li 30 lub hlis - 0.025-0.05 g txij li 2 xyoos txog 4 xyoos - 0.2-0, 8 g los ntawm 4 xyoo txog 10 xyoo-txog 1 g los ntawm 10 xyoo txog 15pet-0.5-1.5 g. Qhov koob tshuaj txhua hnub tau muab faib ua ob peb koob tshuaj. Sab sij huam. Dyspepsia, mob plab zom mov, tinnitus, hnov ​​lus tsis zoo, kev ua xua, ACETYL SALICYLIC ACID (ASPIRINE) contraindications. Cov. Pais plab thiab duodenal mob rwj, ntshav txaus nyiam, gout, mob raum, cev xeeb tub. ACETYL SALICYLIC ACID (ASPIRINE)

Acetylsalicylic acid tau paub zoo nyob hauv Bayer lub npe “Aspirin”.

Mechanism ntawm kev ua

Acetylsalicylic acid inhibits qhov tsim ntawm prostaglandins thiab thromboxanes, vim tias nws yog ib qho tsis paub kev tiv thaiv ntawm cyclooxygenase (PTGS), ib qho enzyme koom nrog lawv cov synthesis. Acetylsalicylic acid ua cov tshuaj acetylating thiab koom nrog cov pab pawg neeg acetyl mus rau serine seem hauv qhov chaw nquag ntawm cyclooxygenase.

Antiaggregant kev txiav txim

Ib qho tseem ceeb ntawm acetylsalicylic acid yog nws lub peev xwm siv tawm tsam cov nyhuv antiplatelet, i.e. inhibit qhov tshwm sim thiab hle platelet aggregation.

Cov yeeb tshuaj uas muaj cov tshuaj antiplatelet yog siv dav hauv tshuaj rau kev tiv thaiv cov ntshav txhaws hauv cov neeg uas tau myocardial infarction, mob qog nqaij hlav, nrog rau lwm cov kev mob tshwm sim ntawm atherosclerosis (piv txwv li, angina pectoris, cuam tshuam ntawm kev sib deev), thiab tseem muaj kev pheej hmoo ntawm cov hlab plawv. Txoj kev pheej hmoo yog suav tias "siab" thaum qhov kev pheej hmoo ntawm kev tsim cov tsis muaj ntshav phom myocardial infarction lossis tuag vim mob plawv 10 xyoo tom ntej tshaj 20%, lossis kev pheej hmoo tuag los ntawm ib qho kab mob plawv (suav nrog mob hlab ntsha tawg) hauv 10 xyoo tom ntej tshaj 5%.

Nrog rau kev los ntshav tsis xws luag, piv txwv li, nrog hemophilia, muaj peev xwm los ntshav ntau ntxiv.

Cov tshuaj aspirin, raws li txhais tau tias ntawm thawj thiab qib qis prophylaxis ntawm cov mob atherosclerosis, tuaj yeem siv tau zoo hauv koob / hnub, cov koob tshuaj no tau zoo rau hauv qhov piv ntawm kev ua haujlwm / kev nyab xeeb.

Sab sij huam

Kev nyab xeeb txhua txhua hnub ntawm tshuaj aspirin: 4 g. Kws kho mob keeb kwm ntseeg tias kev siv tshuaj aspirin ntau dua (kab ntsig) ua rau neeg tuag coob thaum xyoo 1918 kev mob khaub thuas kis thoob plaws.

Cov thiaj li hu ua mob rwj (ua rau lub ntsej muag lossis exacerbation ntawm lub plab rwj thiab / lossis mob duodenal) qhov kev coj ua yam ntxwv ntawm ib theem lossis lwm pawg ntawm cov tshuaj tiv thaiv: ob leeg corticosteroid thiab tsis-steroidal (piv txwv li, butadione, indomethacin, thiab lwm yam.) Cov tsos mob ntawm lub plab thiab lub plab zom mov nrog acetylsalicylic acid Nws tau piav qhia tsis yog tsuas yog los ntawm kev ua kom zoo ntxiv (inhibition ntawm cov ntshav coagulation yam, thiab lwm yam), tab sis kuj los ntawm nws cov kev cuam tshuam ncaj qha rau lub plab hnyuv, tshwj xeeb tshaj yog tias siv yeeb tshuaj Nrog rau qhov ua ntev ntawm cov ntsiav tshuaj tsis muaj kab mob. Qhov no tseem siv rau cov ntsev salicylate. Nrog rau lub sijhawm ntev, tsis muaj kev saib xyuas kev kho mob, kev siv cov tshuaj acetylsalicylic acid, cov kev mob tshwm sim xws li dyspeptic tsis txaus thiab lub plab zom mov tuaj yeem pom.

Txhawm rau txo cov nyhuv ulcerogenic thiab lub plab zom mov, koj yuav tsum noj tshuaj acetylsalicylic acid (thiab sodium salicylate) tsuas yog tom qab noj mov, nws pom zoo kom ua tib zoo zuaj lub ntsiav tshuaj thiab haus dej kom ntau (zoo dua cov kua mis). Txawm li cas los xij, muaj pov thawj tias kev mob plab zom mov kuj tseem tuaj yeem tshwm sim nrog acetylsalicylic acid tom qab noj mov. Sodium bicarbonate pab txhawb kom muaj kev tso tawm ntau dua ntawm salicylates los ntawm lub cev, txawm li cas los xij, kom txo qis qhov tsis zoo nyob rau ntawm lub plab, lawv siv mus haus dej alkaline ntxhia dej los sis tov nrog sodium bicarbonate tom qab acetylsalicylic acid.

Txawv teb chaws, acetylsalicylic acid ntsiav tshuaj yog tsim nyob rau hauv lub plhaw (acid-resistant) plhaub kom tsis txhob muaj kev sib cuag ncaj qha ntawm ASA nrog phab ntsa ntawm lub plab.

Nrog rau kev siv salicylates ntev ntev, qhov ua tau ntawm kev tsim muaj ntshav khov yuav tsum raug coj mus rau hauv tus account thiab cov ntshav kuaj ntshav yuav tsum tau ua thiab cov ntshav yuav tsum kuaj xyuas cov quav.

Vim tias qhov muaj qhov tsis haum, qhov yuav tsum tau ceev faj thaum siv tshuaj acetylsalicylic acid (thiab lwm yam salicylates) rau cov neeg uas muaj kev cuam tshuam ntau dua rau cov tshuaj penicillins thiab lwm cov tshuaj "allergenic".

Nrog rau kev nkag siab ntau ntxiv rau cov tshuaj acetylsalicylic acid, tshuaj aspirin hawb pob tuaj yeem tsim kho, rau kev tiv thaiv thiab kev kho mob uas txoj kev kho txoj kev kho tsis tau zoo tau tsim los ntawm kev siv cov tshuaj aspirin ntau dua.

Nws yuav tsum raug sau tseg tias nyob rau hauv kev cuam tshuam ntawm acetylsalicylic acid, qhov cuam tshuam ntawm anticoagulants (derivatives ntawm coumarin, heparin, thiab lwm yam), txo cov tshuaj qab zib (derivatives ntawm sulfonylureas) nce, kev pheej hmoo ntawm kev mob plab zom mov nce thaum siv corticosteroids thiab tsis siv tshuaj tiv thaiv kab mob (NSAIDs), kev mob tshwm sim. Cov nyhuv ntawm furosemide, uricosuric tus neeg sawv cev, spironolactone yog qee qhov tsis muaj zog.

Hauv cov menyuam yaus thiab poj niam cev xeeb tub

Hauv kev sib txuas nrog cov ntaub ntawv sim ua rau muaj txiaj ntsig teratogenic nyhuv ntawm acetylsalicylic acid, nws raug nquahu kom tsis txhob sau nws thiab cov kev npaj muaj nws rau cov poj niam hauv thawj 3 lub hlis uas cev xeeb tub.

Noj cov tshuaj uas tsis yog-siv yeeb tshuaj (tshuaj aspirin, ibuprofen, thiab paracetamol) thaum cev xeeb tub ua rau muaj kev pheej hmoo ntawm chaw mos ua txhaum rau cov menyuam tub tshiab ua qauv ntawm cryptorchidism. Cov txiaj ntsig ntawm txoj kev tshawb pom tau qhia tias kev siv ntau yam ntawm ob ntawm peb cov tshuaj uas tau teev tseg thaum cev xeeb tub muaj feem yuav muaj menyuam nrog cryptorchidism txog 16 zaug piv nrog cov pojniam uas tsis siv cov tshuaj no.

Tam sim no, muaj cov pov thawj ntawm kev pheej hmoo ntawm kev siv cov tshuaj acetylsalicylic acid rau cov menyuam yaus uas muaj lub hom phiaj txo qis kub thaum kis mob khaub thuas, mob ua pa nyuaj thiab lwm cov kab mob febrile nyob rau hauv kev sib txuas nrog cov kev soj ntsuam ntawm kev txhim kho Reye's syndrome (Reye) (hepatogenic encephalopathy). Lub pathogenesis ntawm kev txhim kho Reye's syndrome tsis paub. Tus kab mob tau nyaij nrog txoj kev loj hlob ntawm kev mob siab mob siab. Qhov tshwm sim ntawm Reye cov tsos mob ntawm cov menyuam yaus hnub nyoog qis dua 18 xyoo nyob rau hauv Tebchaws Meskas yog kwv yees li 1: thaum lub sijhawm cov neeg tuag coob dua 36%.

Yam khoom muaj zog

Acetylsalicylic acid yog dawb lub koob me me-zoo li cov muaju lossis lub teeb ci crystalline hmoov, soluble me ntsis hauv dej ntawm chav sov, soluble hauv dej kub, yooj yim soluble hauv cawv, kev daws ntawm caustic thiab carbonic alkalis.

Acetylsalicylic acid decomposes thaum hydrolysis rau hauv salicylic thiab acetic acids. Hydrolysis yog nqa tawm los ntawm kev daws kev daws ntawm acetylsalicylic acid hauv dej rau 30 s. Tom qab txias, salicylic acid, tsis zoo soluble nyob rau hauv dej, precipitates nyob rau hauv daim ntawv ntawm fluffy koob muaju.

Negligible tus nqi ntawm acetylsalicylic acid pom nyob rau hauv cov tshuaj tiv thaiv nrog Cobert reagent nyob rau hauv muaj cov sulfuric acid (2 ntu ntawm sulfuric acid, ib feem ntawm Cobert's reagent): cov tshuaj tig liab dawb (qee zaum yuav tsum muaj cua sov). Acetylsalicylic acid coj cwj pwm hauv qhov teeb meem no zoo nkaus li salicylic acid.

Cov tshuaj aspirin yog cov tshuaj uas tsis yog tshuaj steroidal siv los daws qhov mob, txo qhov kub taub hau, thiab tseem yog ib qho prophylaxis ntawm thrombosis.

Cov tshuaj nquag - acetylsalicylic acid - muaj ib qho tshuaj tiv thaiv (analgesic), antipyretic, nyob rau hauv cov koob tshuaj loj - cov nyhuv tawm tsam. Nws muaj antiaggregant (tiv thaiv qhov tsim ntawm ntshav txhaws) kev ua si.

Lub tswv yim tseem ceeb ntawm kev ua ntawm acetylsalicylic acid yog qhov tsis paub kev ua haujlwm (kev txwv ntawm kev ua si) ntawm cyclooxygenase enzyme (ib qho enzyme muab kev koom tes hauv cov synthesis ntawm prostaglandins hauv lub cev), vim qhov kev sib txuas ntawm cov prostaglandins cuam tshuam. (Prostaglandins yog cov tshuaj lom biologically active tsim tawm hauv lub cev. Lawv lub luag haujlwm hauv lub cev yog qhov muaj txiaj ntsig heev, tshwj xeeb, lawv yog lub luag haujlwm rau qhov pom ntawm qhov mob thiab o ntawm qhov chaw ntawm o).

Feem ntau, cov tshuaj aspirin hauv kev siv tshuaj ntau (300 mg - 1 g) yog siv los txo qhov kub ntawm cov neeg mob uas mob voos ua pa thiab mob khaub thuas, kom txo cov leeg, mob pob txha thiab mob taub hau.

Cov tshuaj aspirin puas pab nrog kev dai?

Feem ntau, cov tshuaj yuav pab tua cov mob hangover. Cov ntsiav tshuaj Effervescent zoo tshaj plaws los ua kom yaj ntawm dej thiab qaug cawv. Lawv tau tsim tshwj xeeb los tawm tsam cov tsos mob ntawm lub hangover thiab muaj cov tshuaj ntxiv tshwj xeeb (cov nqus thiab cov vitamin C) uas muaj cov nyom ntawm lub cev.

Ua ntej tshaj plaws, cov tshuaj aspirin “daws cov ntshav” thiab txo qis ntshav siab, vim tus neeg mob sai sai tom qab noj tshuaj tas.

Nws muaj mob tob hau thiab nws txoj kev nco qab zuj zus. Tsis tas li ntawd, haus cawv ua rau cov ntshav tuab heev, uas tuaj yeem ua rau cov ntshav txhaws hauv cov hlab ntsha, thiab acetylsalicylic acid, ntawm qhov tsis tooj, dilutes nws.

Cov lus qhia rau kev siv tshuaj Aspirin ntau npaum

Cov tshuaj noj nrog cov tshuaj ntau dua 325 mg (400-500 mg thiab sab saum toj) yog tsim los siv ua tshuaj pleev tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob - hauv koob tshuaj txij li 50 txog 325 mg - feem ntau yog siv tshuaj tiv thaiv tshuaj antiplatelet.

Cov ntsiav tshuaj tshwj xeeb tau noj ntawm qhov ncauj nrog qhov dej ntau (iav), cov ntsiav tshuaj effervescent yog pre-yaj hauv lub khob dej (kom txog thaum ua kom tiav kev tshem tawm thiab kev ua kom tsis hnov ​​qab).

Cov neeg laus thiab cov menyuam hnub nyoog tshaj 15 xyoos nrog mob qhov mob me me mus rau mob nyhav thiab febrile, cov lus qhia rau kev siv pom zoo kom noj cov tshuaj aspirin:

• ib koob tshuaj ntawm 500 mg rau 1 g,
• qhov ntau tshaj koob tshuaj yog 1 g,
• qhov siab tshaj plaws niaj hnub noj yog 3 grams.

Lub sijhawm nruab nrab ntawm cov koob tshuaj yuav tsum yog tsawg kawg 4 teev.

Kuv yuav siv sijhawm ntev npaum li cas tshuaj aspirin? Noj tshuaj (tsis tau sab laj nrog kws kho mob) yuav tsum tsis pub ntau tshaj 7 hnub thaum tshuaj kom ua tshuaj loog thiab ntau dua 3 hnub ua ib qho tshuaj tiv thaiv kab mob.

Txhawm rau txhim kho qhov mob rheological ntawm cov ntshav - ntawm 150 txog 250 mg rau ib hnub rau ntau lub hlis.

Nrog rau myocardial infarction, ntxiv rau kev tiv thaiv kab mob thib ob hauv cov neeg mob tom qab myocardial infarction, Aspirin noj hauv ib koob li 40 rau 325 mg 1 lub sijhawm hauv ib hnub (feem ntau 160 mg).

Raws li ib qho inhibitor ntawm platelet sib sau - 300-325 mg ib hnub rau ntev.

Nrog lub cev nqaij daim tawv tsis txaus nyob hauv cov txiv neej, mob hlwb - 325 mg rau ib hnub nrog maj mam nce mus txog qhov ntau ntawm 1 g ib hnub. Txog kev tiv thaiv kom rov huam mob - 125-300 mg ib hnub twg.

Rau kev tiv thaiv ntawm thrombosis lossis occlusion ntawm aortic shunt, 325 mg txhua 7 teev los ntawm kev mob plab hnyuv plab, ces 325 mg rau qhov ncauj 3 zaug hauv ib hnub (feem ntau yog ua ke nrog dipyridamole, uas tau muab tshem tawm tom qab ib lub lim tiam, txuas ntxiv kev kho mob ntev nrog ASA).

Tam sim no, kev siv tshuaj Aspirin los ua cov tshuaj tiv thaiv kev tiv thaiv kab mob hauv tshuaj txhua hnub ntawm 5-8 g yog qhov txwv, vim qhov muaj feem ntau tshwm sim los ntawm kev mob tshwm sim ntawm txoj hnyuv plab hnyuv (NSAIDs gastropathy).

Ua ntej kev phais mob, txhawm rau txo los ntshav thaum phais thiab tom qab lub sijhawm txiav txim siab, koj yuav tsum tshem lub sijhawm teem sijhawm 5-7 hnub thiab qhia tus kws kho mob.

Thaum siv cov tshuaj aspirin mus sij hawm ntev, yuav tsum tau kuaj ntshav ib qho thiab kuaj ntshav cov ntshav tsis tso ntshav.

Txawm hais tias siv me me, nws txo qhov kev tsis haum ntawm uric acid los ntawm lub cev, uas tuaj yeem ua rau muaj kev txhim kho ntawm kev mob hnyav ntawm gout nyob rau hauv cov neeg mob yooj yim.

Cov tshuaj Aspirin, cov nqi hauv cov khw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Aspirin nrog cov tshuaj tiv thaiv ntawm cov tshuaj nquag - cov no yog cov tshuaj:

Thaum xaiv cov tshuaj analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv tshuaj Aspirin, tus nqi thiab tshuaj xyuas cov tshuaj nrog cov teebmeem zoo sib xws tsis siv. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Tus nqi hauv cov khw muag tshuaj ntawm Russia: effervescent ntsiav tshuaj Aspirin nthuav qhia 500mg 12pcs. - los ntawm 230 txog 305 rubles, ntsiav tshuaj 300 mg 20 pcs. - txij li 75 txog 132 rubles, raws li 932 cov chaw muag tshuaj.

Khaws rau hauv qhov chaw qhuav ntawm qhov kub tsis tshaj 30 ° C. Txee lub neej yog 5 xyoos. Cov lus pom zoo tso tawm los ntawm cov chaw muag tshuaj - yam tsis muaj ntawv yuav tshuaj.

Yeeb tshuaj sib cuam tshuam

Acetylsalicylic acid ua rau cov tshuaj lom hu ua methotrexate, nrog rau cov txiaj ntsig tsis pom kev ntawm triiodothyronine, narcotic analgesics, sulfanilamides (suav nrog co-trimoxazole), lwm yam tshuaj NSAIDs, thrombolytics - platelet aggregation inhibitors, tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj, cov tshuaj anticoagulant. Nyob rau tib lub sijhawm, nws tsis muaj zog cov nyhuv ntawm diuretics (furosemide, spironolactone), tshuaj tiv thaiv kabmob, thiab cov tshuaj uricosuric (probenecid, benzbromarone).

Thaum ua ke nrog cov tshuaj ethanol uas muaj cov tshuaj cawv, cawv thiab glucocorticosteroids, ua rau muaj kev puas tsuaj ntawm ASA ntawm lub plab hnyuv nce ntxiv, uas ua rau muaj kev phom sij los ntshav.

Acetylsalicylic acid ua rau kev nce siab ntawm cov roj ntsha lithium, barbiturates thiab digoxin hauv lub cev nrog kev siv tib lub sijhawm. Antacids, uas suav nrog txhuas thiab / lossis magnesium hydroxide, qeeb thiab txo qhov nqus ntawm ASA.

Cov tshuaj aspirin puas zoo lossis tsis zoo rau lub cev?

Qhov txiaj ntsig ntawm Aspirin yog tias nws pab tau ntau yam ua rau analgesic, antipyretic thiab anti-inflammatory tus neeg sawv cev. Hauv cov koob tshuaj qis dua, nws yog siv los tiv thaiv kev txhim kho ntawm cov teeb meem vascular.

Niaj hnub no nws yog tib qho kev sib cais, qhov kev ua tau zoo uas thaum siv nyob rau hauv lub sijhawm muaj sij hawm ntawm ischemic stroke (cerebral infarction) tau txais kev txhawb nqa los ntawm cov pov thawj tshuaj.

Nrog rau kev siv tsis tu ncua, qhov kev pheej hmoo ntawm mob qog nqaij hlav cancer, nrog rau mob qog ntawm prostate, ntsws, txoj hlab pas thiab qa, tau txo qis.

Ib qho tseem ceeb ntawm Aspirin cov txiaj ntsig yog tias nws tsis tuaj yeem tiv thaiv COX, ib qho enzyme uas tau koom nrog hauv kev coj ua ntawm thromboxanes thiab Pg. Ua raws li tus neeg sawv cev rau acetylating, ASA tau txuas rau qhov seem ntawm serine hauv qhov chaw nquag ntawm pawg COX acetyl. Qhov no cais cov tshuaj los ntawm lwm cov NSAIDs (tshwj xeeb, los ntawm ibuprofen thiab diclofenac), uas zwm rau pawg ntawm thim rov qab COX inhibitors.

Cov neeg tawm dag zog siv cov Aspirin-Caffeine-Broncholitin ua ke zoo li cov roj ua rau lub cev rog (qhov sib xyaw no yog suav tias yog qhov tshwm sim ntawm txhua lub roj hlawv). Cov niam tsev tau pom tias kev siv ASA hauv lub neej txhua hnub: cov khoom lag luam feem ntau yog siv los tshem tawm cov hws hle khaub ncaws los ntawm cov khaub ncaws dawb thiab kom cov dej av cuam tshuam los ntawm cov pwm.

Cov tshuaj aspirin tseem pom cov txiaj ntsig rau cov paj - cov ntsiav tshuaj nyem tau ntxiv rau hauv dej thaum lawv xav ua kom cov nroj tsuag txiav ntev dua.

Qee tus poj niam siv cov ntsiav tshuaj ua rau muaj kev siv tshuaj tiv thaiv: kom cov ntsiav tshuaj muab tshuaj rau hauv lub sijhawm 10-15 feeb ua ntej PA lossis yaj nws hauv dej thiab tom qab ntawd maj nrog cov tshuaj uas muaj txiaj ntsig. Qhov ua tau zoo ntawm hom no ntawm kev tiv thaiv cev xeeb tub tseem tsis tau raug tshawb fawb, txawm li cas los xij, cov kws kho mob poj niam tsis lees paub txoj cai rau nws muaj.Tib lub sijhawm, cov kws kho mob nco tau tias qhov ua tau zoo ntawm kev tswj kom tsis txhob muaj menyuam tsuas yog muaj li 10% xwb.

Cov txiaj ntsig thiab kev phom sij ntawm Aspirin nyob ntawm kev siv raug thiab ua raws li cov lus qhia, thiab txawm hais tias muaj neeg coob ntawm cov khoom muaj txiaj ntsig, cov tshuaj muaj peev xwm ua rau muaj kev phom sij. Yog li, kev tsuj tawm ntawm COX cov dej num ua rau qhov kev ua txhaum ntawm kev ncaj ncees ntawm cov phab ntsa ntawm cov kwj dej zom mov thiab yog qhov tseem ceeb rau kev txhim kho mob plab peptic.

Tsis tas li, qhov txaus ntshai ASA tuaj yeem ua rau me nyuam qis dua 12 xyoos. Yog tias siv yog tias tus me nyuam muaj kab mob kis, cov tshuaj yuav ua rau tus mob Reye's syndrome, tus kab mob uas cuam tshuam rau lub neej ntawm cov neeg hluas.