Cov tshuaj FORMIN - cov lus qhia, tshuaj xyuas, tus nqi thiab analogues

Metformin belongs rau cov chav kawm ntawm biguanides, qhov ua kom lub ntsej muag hypoglycemic uas yog los ntawm kev poob qis hauv cov ntaub so ntswg insulin tsis kam, thiab nce ntxiv nyob rau hauv cov piam thaj los ntawm cov rog thiab cov leeg nqaij. Cov tshuaj inhibits qhov nqus ntawm cov piam thaj hauv cov hnyuv, thaiv gluconeogenesis, tswj cov metabolism hauv lipid. Metformin tseem muaj txiaj ntsig zoo ua rau cov hlab ntshav ntshav, tiv thaiv kev mob ntshav qab zib hauv ntshav qab zib.

Cov tshuaj tsis txhawb cov hlwb hlwb rau insulin ntau lawm, yog li nws muaj kev nyab xeeb hauv kev sib raug zoo rau kev txhim kho hauv lub qog ntshav qab zib.

Tom qab kev tswj hwm, kev kho mob siab tshaj plaws tau txhim kho tom qab 2 teev, tag nrho lub sijhawm ua ntawm 6 teev.

Cov tshuaj yog qhia rau kev kho mob ntshav qab zib hom 2, tshwj xeeb tshaj yog cov rog rog, nyob rau hauv qhov tsis muaj kev noj haus thiab kev tawm dag zog.

Cov Yuav Tsum Muaj

nyiam lactic acidosis (tsub zuj zuj hauv cov kab mob lactic acid)
ketoacidosis
ntshav qab zib hom 1
cev xeeb tub
cov me nyuam muaj hnub nyoog
hypoglycemia thiab mob ntshav qab zib coma
mob rau daim siab thiab lub raum tsis ua hauj lwm zoo
haus cawv ntev zuj zus
decompensated kab mob plawv
kev tiv thaiv tsis haum.

Dosage thiab txoj kev ntawm cov thawj coj

Tsuas tshuaj yog teem ib lub zuj zus, noj mus rau hauv tus account glycemia thiab glycosuria.

Thawj koob tshuaj formin yog 850 mg / hnub. Nyob rau ntawm ob lub lis piam, ntau npaum li cas yog maj maj kom txog thaum muaj kev tswj ruaj khov glycemic tiav. Txij nkawm koob tshuaj - 2 ntsiav tshuaj / hnub.

Qhov tso cai niaj hnub niaj hnub yog 3 ntsiav tshuaj.

Cov koob tshuaj ntau dua 1 ntsiav tshuaj yuav tsum tau muab faib ua ob zaug. Siv cov tshuaj thaum noj mov lossis tom qab noj mov. Thaum noj ua ntej noj mov, lub sij hawm kom ua tiav cov txiaj ntsig kho tau ntev ntev.

Rau cov neeg mob tom qab 60 xyoo thiab muaj teeb meem ntawm cov metabolism hauv lub cev ntau ntxiv, ua kom ntau npaum li cas ntawm kev ceeb toom.

Sab sij huam

lactic acidosis (nrog mob siab rau lub raum lossis lub raum tsis ua hauj lwm, haus cawv mus rau hauv lub plawv, lub plawv tsis ua haujlwm)
ntshav qog
mob plab hnyuv: ua rau tsis nco qab, raws plab, xeev siab, hnov qab hauv plab, mob plab (tshwm sim thaum pib kho lossis muaj qhov tsis nco meej ntau ntxiv)
malabsorption ntawm cov vitamins B12 thiab B9
ua xua dermatitis.

Formin yog tshuaj rau monotherapy lossis hauv kev sib xyaw nrog sulfonylurea lossis insulin. Ua ke nrog kev kho mob nrog cov tshuaj insulin yog nqa tawm hauv tsev kho mob kom txog thaum qhov kev noj tshuaj zoo tsim los tiv thaiv kev txhim kho hypoglycemia.

Thaum lub sijhawm tsim cov tshuaj formin, nws yog ib qho tsim nyog los tswj cov theem ntawm cov ntshav creatinine ib zaug txhua rau lub hlis, thiab ib xyoos ib zaug los tshuaj xyuas cov ntshav rau theem ntawm vitamin B12.

Hauv kev kho mob nrog formin, cawv yog qhov xav tsis tau.

Kev siv tib lub formin nrog cov tshuaj rau kev kho tus kab mob concomitant tuaj yeem txhim kho lossis txo nws cov nyhuv hypoglycemic. Yog li, tib lub sijhawm tswj hwm ntawm ntau cov tshuaj yuav tsum tswj hwm los ntawm tus kws kho mob mus kawm, coj mus rau hauv tus account cuam tshuam nrog tshuaj.

Cov lus qhia rau kev siv tshuaj

Yog lawm, yuav luag txhua tus neeg mob ib txwm sim kawm cov lus qhia los ntawm cov neeg tsim khoom ua ntej siv cov tshuaj. Thiab qhov no yog txoj cai txiav txim siab. Qhov tseeb tiag, tsuas yog hauv qhov no nws yuav muaj peev xwm txiav txim rau koj tus kheej tias yuav muaj kev phiv dab tsi vim kev siv tshuaj tsis raug cai, nrog rau nws cuam tshuam li cas rau lub cev thiab muaj txiaj ntsig zoo li cas los ntawm kev siv lub sijhawm ntev.

Yuav pib nrog, nws yuav tsum raug sau tseg tias cov tshuaj tau faib rau hauv cov qauv ntawm cov ntsiav tshuaj. Muaj cov pob khoom uas muaj peb caug ntsiav tshuaj, thiab muaj cov uas muaj rau caum.

Cov nyhuv pharmacological tseem ceeb uas Formin Pliva tau tshwm sim hauv qhov tseeb tias tom qab nws siv sijhawm ntev, nws muaj peev xwm ua tau kom txo qis ntshav qabzib hauv cov ntshav ntawm tus neeg mob. Ntxiv mus, nws raug nquahu kom coj nws mus rau cov neeg mob uas muaj insulin-ywj siab, uas yog, cov uas tsis txhaj tshuaj insulin.

Qhov khoom muaj txiaj ntsig zoo no muaj peev xwm ua tau vim muaj qhov tseeb tias cov tshuaj yeeb yam tseem ceeb ua kom zoo rau kev siv cov kua nplaum kom zoo. Vim li ntawd, txhua txoj kev ua haujlwm ntawm gluconeogenesis uas tshwm sim hauv lub siab raug tiv thaiv. Qhov nqus ntawm cov paib ntshiab uas muaj nyob rau hauv cov hnyuv ntawm ib tug neeg twg kuj tau txo qis.

Lwm qhov ua tau zoo uas paub qhov txawv ntawm Formin Pliva yog tias nws ua rau kom qhov nce ntawm qhov rhiab ntawm tag nrho cov ntaub so ntswg lub cev mus rau insulin. Yog vim li ntawd, nws thiaj li muaj peev xwm ua tau kom txo qis qib ntshav qab zib hauv cov ntshav ntawm tus neeg mob.

Muaj tseeb, yog tias peb tham txog seb nws puas yuav ua tau kom nce txheej txheem ntawm kev tsim cov tshuaj insulin hauv lub cev vim tias siv ntev heev ntawm kev siv tshuaj, tom qab no qhov tshwm sim yuav pom qhov tsis txaus ntseeg.

Tab sis nws paub tias tom qab noj Formin, muaj ib qho kev txo qis ntawm cov triglycerides hauv tus neeg mob cov ntshav, nrog rau qhov txo qis ntawm kev coagulability ntawm cov kua aforementioned.

Cov tshuaj yog coj mus rau sab hauv, qhov siab tshaj plaws ntawm cov khoom tseem ceeb hauv lub cev tau ua tiav ob teev tom qab kev tswj hwm. Tab sis nws qhov kawg nqus hauv cov ntshav tshwm sim tom qab rau teev.

Nws yog tawm los ntawm tus neeg mob los ntawm ob lub raum.

Thaum twg thiaj li pib noj tshuaj?

Nws twb tau hais saum toj no tias nws tsim nyog pib noj tshuaj tsuas yog tom qab sab laj nrog koj tus kws kho mob ua ntej. Koj tsis tuaj yeem pib kev kho mob ywj siab nrog hom tshuaj no.

Feem ntau, hauv cov pawg ntawm cov neeg mob uas pom zoo rau Formin Pliva, cov neeg mob no tau kuaj pom tias muaj tus mob ntshav qab zib hom 2.

Thiab feem ntau cov no yog cov neeg mob uas muaj teeb meem pom tseeb nrog kev rog dhau los, nrog rau cov uas tsis noj tshuaj insulin los ntawm kev txhaj tshuaj.

Tab sis nws tseem ceeb heev kom nco ntsoov tias Formin pliva muaj qhov tsis zoo. Nws yog contraindicated nyob rau hauv cov ntaub ntawv no:

thaum tus neeg mob ketoacidosis los yog mob ntshav qab zib tsis zoo,
nws tseem tuaj yeem yog thaum tus neeg mob tiv thaiv ntau yam kabmob sib kis lossis phais mob, vim tias nws tau raug ntaus nqi ntawm cov tshuaj insulin hauv kev txhaj tshuaj,
cov contraindications tseem muaj cov teeb meem pom tseeb nrog kev ua haujlwm ntawm lub plawv, nrog rau txhua yam kev mob tshwm sim ntawm kev mob nkeeg ntawm cov khoom nruab nrog cev no,
koj yuav tsum tsis txhob noj cov tshuaj thaum cev xeeb tub lossis thaum lub sijhawm tus poj niam noj niam mis,
thiab qhov tseeb, thaum muaj ib tus neeg tsis kam mus rau cov khoom siv uas yog ib feem ntawm cov tshuaj.

Kev tshuaj xyuas ntawm ntau tus neeg mob qhia tias nws yog ib qho tseem ceeb kom ua raws li kev noj haus tshwj xeeb thaum kho nrog cov tshuaj no.

Nws yuav tsum yog qhov tsawg kawg ntawm calories thiab pab txhawb qhov hnyav ua kom poob ntawm tus neeg mob. Qhov no tseem tau thov los ntawm yuav luag txhua tus kws tshaj lij.

Dab tsi yog cov analogues thiab lawv cov nqi?

Zoo li lwm yam tshuaj, Formin Pliva nws muaj nws ib qho analogues. Lawv cov nqi feem ntau nyob ntawm qhov chaw tsim khoom lub tuam txhab, uas yog, nyob rau hauv lub teb chaws twg cov tshuaj no tau ua. Yog tias peb tab tom tham txog qhov tseeb tias qhov no yog tus neeg sawv cev thoob ntiaj teb, ces nws tus nqi, ntsig txog, yuav muaj ntau zaus ntau dua li tus kws tshaj lij Lavxias.

Nyob rau hauv txhua rooj plaub, ua ntej pib kev kho mob rau lwm tus mob, koj yuav tsum sab laj nrog koj tus kws kho mob. Koj yuav tsum nrhiav kom paub nws los ntawm kev phiv dab tsi tuaj yeem tshwm sim los ntawm ib qho yeeb tshuaj, nrog rau dab tsi contraindications muaj rau nws siv. Nws yog ib qho tseem ceeb uas yuav tsum tau kuaj tag nrho thiab tsuas yog tom qab ntawd pib kho nrog Formin Pliva, cov lus qhia rau kev siv tshuaj piav qhia nyob rau hauv qhov xwm txheej twg siv cov tshuaj, thiab noj dab tsi.

Qee lub sij hawm thaum pib kho los ntawm kev mob plab, qee qhov tsis xis nyob yuav tshwm sim. Qhov no nws qov nws tus kheej hauv daim ntawv ntawm xeev siab lossis ntuav. Nws tseem muaj peev xwm ua tau kom txo qis qhov qab los yog qhov txawv hauv lub qhov ncauj.

Qee cov neeg mob qhia txog pob khaus tawv nqaij nrog ntshav qab zib. Yog lawm, yog tias koj haus cov tshuaj kom ntau dhau, tom qab ntawv yuav cuam tshuam txog kev noj qab haus huv ntau dua tuaj.

Yog tias peb tham txog cov analogues twg yog cov neeg nyiam tshaj plaws niaj hnub no, tom qab ntawd, piv txwv li, ntau tus kws kho mob tuaj yeem sau cia Bagomet, nws tus nqi pib ntawm 130 thiab nce mus txog 220 rubles rau ib pob, nyob ntawm seb muaj pes tsawg ntsiav tshuaj hauv nws. Tus nqi kuj tseem cuam tshuam los ntawm kev saib xyuas cov khoom tseem ceeb, piv txwv li, ib pob khoom ntawm rau caum dauv ntawm 850 mg yog kwv yees li 220 rubles, tab sis tib tus naj npawb ntawm 1000 mg ntsiav tshuaj twb raug nqi me ntsis ntau dua plaub puas rubles.

Kuj tseem muaj ib qho analogue zoo li Glycon. Nws tus nqi kuj yog nyob ntawm qhov kev txiav txim siab ntawm cov khoom tseem ceeb thiab cov lej ntawm cov ntsiav tshuaj. Nws nyob ntawm 115 txog 280 rubles. Lub teb chaws ntawm kev tsim cov tshuaj no, xws li yav dhau los, yog Argentina.

Tab sis yog qhov uas nws yuav tshwm sim, koj yuav tsum tsis txhob hloov nws tus kheej cov tshuaj uas koj tus kws kho mob pom zoo, txwv tsis pub koj tsuas tuaj yeem cuam tshuam koj txoj kev noj qab haus huv.

Cov yeeb yaj kiab hauv tsab xov xwm no piav qhia txog yuav ua li cas noj Formin thiab lwm yam tshuaj kom raug.

Cov Tshuaj Pharmacokinetics

Tom qab kev coj noj coj ua, cov tshuaj tseem ceeb yuav nqus tau los ntawm kev mob hauv txoj hnyuv. Bioavailability tuaj yeem ncav cuag 60%. Qhov siab tshaj plaws ntshav plasma yog pom tom qab 2 teev.

PAB! Nkag mus nrog cov zaub mov txo qhov siab tshaj plaws ntawm cov tshuaj los ntawm 40%, cov txiaj ntsig kho tag nrho tshwm sim 35 feeb tom qab.

Nws nthuav tawm hauv cov ntshav liab, tsis khi rau ntshav protein. Cumulation yog pom nyob rau hauv cov leeg nqaij, mob siab thiab lub raum, nrog rau hauv cov qog ua salivary.

Qhov kev tshem tawm ib nrab-lub neej yog 6,5 teev.

Nws yog siv rau hom 2 mob ntshav qab zib mellitus, uas yog tus cwj pwm nyiam los ketoacidotic. Lub hauv paus rau kev teem caij cov tshuaj yog qhov tsis muaj txiaj ntsig ntawm kev noj haus.

Sab sij huam

lub plab zom mov: ua rau tsis haum plab (xeev siab, ntuav, kub siab, mob plab), raws plab, tsis txaus siab, tsis qab los noj mov,
endocrine system: txo qis dua cov piam thaj,
metabolism: lactic acidosis, vitamin B tsis txaus₁₂,
hematopoietic system: megaloblastic yam anemia,
daim tawv nqaij: ua pob, khaus.

Noj ntau dhau

xeev siab
ntuav
zawv plab
txo hauv lub cev kub
mob plab
myalgia
pa ceev heev
kiv taub hau
tsis nco qab
kev loj hlob ntawm coma.

Kev kho muaj nrog:

kev tshem tawm ntawm cov kab mob hypoglycemic,
pw tsev kho mob hauv tsev kho mob,
hemodialysis
mob kev kho mob.

Yeeb tshuaj sib cuam tshuam

Kev txhim kho ntawm ntau yam cuam tshuam yog ua tau nrog kev sib txig siv Formin thiab lwm txoj kev. Yog li:

sulfonylurea derivatives (Butamide, Glibenclamide), salicylates (Aspirin, Salicylamide), acarbose, non-steroidal anti-inflammatory (Nimesil, Ketorol), monoaminoxygenase inhibitors (Selegiline, Nialamide), oxytetracycline azolefin cyclopylhenylin (Anaprilin, Concor) txhim kho cov piam thaj txo qis ntawm cov khoom tseem ceeb,
glucocorticosteroids (Beclomethasone, Methylprednisolone), cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj (Regulon, Novinet), glucagon, thyroid hormone analogues (Thyroxine, Thyroidin), thiazide (Indapamide, Chlortiazidium, Efuroteminazidazum, Furoseminazide, Eomurururinida, Eomurururinida Aminazine), nicotinic acid (Cordiamin, Acipimox) tuaj yeem txo cov nyhuv hypoglycemic,
nifedipine nce rau kev nqus, cov ntsiab lus siab tshaj plaws nyob rau hauv ntshav, thaiv cov kev tawm ntawm cov tshuaj nquag,
cimetidine qeeb qeeb kev thauj cov metformin, ua rau muaj kev pheej hmoo ntawm cov kab mob lactic acidosis,
cationic tshuaj (Digoxin, Morphine, Vancomycin) nrog kev siv lub sijhawm ntev tuaj yeem nce cov ntsiab lus ntawm Metformin hauv cov ntshav los ntawm 60%,
anticoagulants tsis muaj zog cov kev ua ntawm tom kawg,
iodine-muaj cov kab mob sib xyaw ua rau kom muaj kev txuam nrog cov tshuaj tseem ceeb ntawm Formin nrog kev txhim kho ntawm lactic acidosis.

Cov lus qhia tshwj xeeb

Hauv kev kho mob nrog cov tshuaj yuav tsum:

tswj raum kev ua haujlwm
los txiav txim siab qhov concentration ntawm lactate hauv cov ntshav ntshav ob zaug ib xyoos,
soj ntsuam cov kua nplaum saib xyuas thaum ua ke nrog insulin, sulfonylurea derivatives.

PAB! Kev phais mob ntxiv, kev raug mob, thaj tsam loj kub hnyiab, kis kab mob thiab kis mob uas tshwm sim nrog kev nce hauv qhov kub thiab txias - txhua qhov no yog qhov qhia rau kev tshem tawm ntawm Formin nrog kev teem sijhawm ntxiv ntawm insulin.

Txais tos thaum laus

Nws yog qhov ua tau rau kev kho mob rau cov neeg uas muaj hnub nyoog 65 xyoos nyob rau hauv kev saib xyuas ze, coj mus rau hauv kev txheeb xyuas qhov kev ntsuas ntawm qhov yuav tshwm sim zoo thiab qhov tsis zoo. Cov neeg mob no yuav tsum txiav txim siab txog kev tsim cov tshuaj creatinine ua ntej pib kev kho mob (ntshav muaj nuj nqi creatinine tsis zoo rau kev soj ntsuam lub raum kev ua haujlwm).

Piv nrog analogues

Cov tshuaj hauv qab no muaj cov tshuaj zoo sib xws:

Vipidia. Cov tshuaj nquag yog alogliptin. Nws cuam tshuam cov hluavtaws ntawm cov tshuaj insulin hauv cov txiav ua kab mob, bioavailability ncav cuag 100%. Nws yog txwv tsis pub nrog hom 1 mob ntshav qab zib mellitus. Siv nrog ceev faj nyob rau hauv muaj pancreatitis, nyob rau hauv ua ke nrog insulin thiab sulfonylureas. Qhov koob tshuaj txhua hnub yog 25 mg. Txais yuav tsis hais noj dab tsi, tsis yoo, tsis haus dej. Tsis muaj kev cuam tshuam nrog lwm cov tshuaj tau raug txheeb xyuas.
Glibenclamide. Cov tshuaj tseem ceeb yog glibenclamide. Nws yog lub zog ntawm cov tshuaj insulin los ntawm Langerhans islet hlwb. Nws txhim kho qhov rhiab heev ntawm cov ntaub so ntswg qauv rau insulin, pab txo lipoproteins, muaj cov nyhuv antithrombotic. Raug rho tawm hauv lub plab zom mov, metabolized los ntawm daim siab mob, ua rau los ntawm lub raum. Nws khi zoo rau cov ntshav protein. Cov koob tshuaj tau teeb tsa ib leeg zuj zus raws li qhov mob hnyav ntawm cov chav kawm mob ntshav qab zib thiab lub hnub nyoog ntawm tus neeg mob.
Miglitol. Blocks cov enzyme alpha-glucosidase ntawm epithelium ntawm txoj hnyuv me. Nws inhibits qhov tawg ntawm polysaccharides rau cov piam thaj, txo nws txoj kev nqus. Yuav luag tsis cuam tshuam nrog cov ntshav protein, lub raum tsis ua haujlwm tsis txawv txav. Cov tshuaj yeeb yaj kiab yog txwv rau kev siv nrog ulcerative colitis, muaj qhov loj ntawm hernias. Nws yuav tsum noj nrog lossis tom qab noj mov.
Av ‡ Q Cov tshuaj nquag yog rosiglitazone. Txhim kho qhov rhiab heev ntawm cov ntaub so ntswg adipose mus rau insulin, pob txha pob txha, mob siab. Nws txhawb cov metabolism hauv, ua kom tsis txhob muaj cov concentration ntawm cov piam thaj, insulin, fatty acids dawb hauv cov hlab ntshav. Nws khi rau cov ntshav protein mus rau qhov siab, uas tsis yog nyob ntawm kev saib xyuas ntawm cov tshuaj thiab lub hnub nyoog ntawm tus neeg mob. Txaus siab los ntawm ob lub raum. Nws yog siv ua ke nrog insulin. Contraindicated nyob rau hauv mob huam mob plawv, lub plawv tsis ua hauj lwm. Kev txais tos yog nqa tawm txawm tias tsis muaj cov khoom noj.
Starlix. Cov tshuaj tseem ceeb yog nateglinide. Nws pab kom rov qab los ntawm theem pib ntawm kev tsim tawm cov tshuaj insulin, nce nws qib hauv thawj 15 feeb tom qab noj mov, vim tias cov piam thaj ntawm cov ntshav hloov pauv yog qib. Kev txais tos yog qhia ib nrab teev ua ntej noj mov 3 zaug hauv ib hnub. Siv nrog ceev faj hauv kev ua haujlwm tsis zoo ntawm daim siab thiab lub raum. Nws tuaj yeem raug siv raws li kev kho mob monotherapy.

Ludmila: “Kuv tus txheeb ze raug kuaj mob ntshav qab zib tau ob peb xyoos dhau los. Txij thaum ntawd los, nws tau noj tshuaj, ib qho yog Formin. Sij hawm dhau los, qab zib nce mus txog 18. Tom qab ntawd txoj kev kho mob pib. Formine puas pab tau? Yog, thiab pom tau heev. Ib tus txheeb ze yuav siv tag nrho cov tshuaj raws nraim li tau hais tseg, tsis muaj kev ntshai los nrhiav pom lawv cov piam thaj hauv qab. Thiab nws nyob qis qis ntawm qib 5-6. "

Olga: “Kuv pog muaj mob ntshav qab zib.Kuv paub tseeb tias kuv yuav tsis muaj qhov no, txij li qhov hnyav thiab qab zib ib txwm nyob hauv ib txwm. Tab sis thaum cev xeeb tub zaum ob, kuaj tau tus mob ntshav qab zib hauv lub cev tau tshwm sim, uas tom qab yug menyuam tau hloov mus rau hauv qhov qub. Tus kws kuaj mob endocrinologist tau sau ntawv rau kuv Formin. Yog ib hom tshuaj zoo heev uas pab ua kom qab zib.

Formin yog ib qho tshuaj tiv thaiv kab mob, tus ua hauj lwm zoo uas tau teev tseg los ntawm ntau tus neeg mob. Nws tsis yog yuav tsum tau ua nws txoj kev tswj hwm ywj siab, txij li muaj ntau yam contraindications. Ua ntej siv, koj yuav tsum sab laj tus kws paub tshwj xeeb uas yuav tuaj yeem soj ntsuam txhua qhov kev pheej hmoo thiab qhov tshwm sim txog kev kho kom zoo.