Rosinsulin P, S, M

Tus neeg sawv cev hypoglycemic, luv luv ua yeeb yam insulin. Sib cuam tshuam nrog ib qhov tshwj xeeb receptor rau ntawm sab nraud ntawm lub hlwb, tsim cov txheej txheem insulin. Los ntawm nce cov synthesis ntawm cAMP (hauv cov roj ntsha thiab lub siab hlwb) lossis nkag ncaj qha rau hauv lub cell (leeg), insulin receptor complex stimulates intracellular processes, suav nrog synthesis ntawm cov lej ntawm cov enzymes tseem ceeb (suav nrog rau hexokinase, pyruvate kinase, glycogen synthetase).

Kev txo qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav yog tshwm sim los ntawm kev nce ntxiv hauv nws txoj kev thauj mus los, kev nqus thiab pov tseg ntau los ntawm cov nqaij mos, ua kom muaj zog ntawm lipogenesis, glycogenogenesis, synthesis protein, thiab txo tus nqi ntawm cov piam thaj los ntawm lub siab (txo qis hauv glycogen tawg).

Qhov pib ntawm kev ua yog tom qab 30 feeb, qhov ua haujlwm siab tshaj plaws yog tom qab 1-3 teev, lub sijhawm ua ntawm yog 8 teev.

Kev noj tshuaj ntxiv

Qhov koob tshuaj thiab txoj hauv kev ntawm kev tswj hwm tshuaj yog txiav txim siab ntawm tus kheej hauv txhua kis raws cov ntsiab lus qabzib hauv cov ntshav ua ntej noj thiab 1-2 teev tom qab noj mov, nrog rau kev kawm tiav ntawm glucosuria thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob.

Raws li txoj cai, s / c muab noj 15-20 feeb ua ntej noj mov. Cov chaw txhaj tshuaj tau hloov pauv txhua zaus. Yog tias tsim nyog, IM lossis IV tswj hwm raug tso cai.

Yuav tuaj yeem ua ke nrog cov insulins ntev ntev.

Sab sij huam

Kev tsis haum tshuaj: urticaria, angioedema, ua npaws, ua tsis taus pa, ua rau muaj ntshav siab.

Los ntawm cov kab mob endocrine: hypoglycemia nrog cov kev ua yeeb yam xws li pallor, nce tawm hws, palpitations, pw tsaug zog, tshee tshee, mob puas siab puas ntsws, cuam tshuam ntawm cov ntshav tiv thaiv kab mob nrog tib neeg cov tshuaj insulin, nce ntxiv ntawm titer ntawm cov tshuaj tiv thaiv insulin nrog kev nce ntxiv ntawm glycemia.

Los ntawm sab ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: cov tsis pom kev tsis pom kev zoo (feem ntau thaum pib kho).

Cov tshuaj tiv thaiv hauv zos: hyperemia, khaus thiab lipodystrophy (mob atrophy lossis hypertrophy ntawm subcutaneous rog) ntawm qhov chaw txhaj tshuaj.

Lwm yam: thaum pib kho, edema yog ua tau (hla nrog kev kho mob txuas ntxiv).

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv qhov kev txo qis hauv qhov xav tau ntawm cov tshuaj insulin hauv thawj peb lub hlis lossis nce ntxiv ntawm zaum ob thiab thib peb. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Thaum lub sijhawm lactation, tus neeg mob xav tau kev soj ntsuam txhua hnub rau ob peb lub hlis (kom txog rau ntawm qhov kev xav tau ntawm insulin).

Cov lus qhia tshwj xeeb

Nrog kev ceev faj, qhov ntau ntawm cov tshuaj raug xaiv hauv cov neeg mob uas muaj cov kab mob cerebrovascular ua ntej lawm raws li hom ischemic thiab nrog cov ntawv hnyav ntawm ischemic mob plawv.
Qhov xav tau ntawm insulin tuaj yeem hloov pauv ntawm cov xwm txheej hauv qab no: thaum hloov mus rau lwm hom insulin, thaum hloov pauv kev noj zaub mov, raws plab, ntuav, thaum hloov qhov ib txwm ntawm kev qoj ib ce, hauv cov kab mob ntawm lub raum, mob siab, pituitary, lub qog caj pas, thaum hloov chaw txhaj tshuaj.
Kev kho cov tshuaj insulin yog qhov tsim nyog rau cov kab mob sib kis, cov thyroid tsis ua haujlwm, Addison's disease, hypopituitarism, mob raum tsis ua haujlwm, thiab mob ntshav qab zib mellitus hauv cov neeg mob uas muaj hnub nyoog 65 xyoos.

Qhov hloov ntawm tus neeg mob mus rau tib neeg cov tshuaj insulin yuav tsum yog ib qho kev txiav txim siab ncaj thiab nqa tawm tsuas yog nyob hauv kev saib xyuas ntawm kws kho mob.

Cov ua rau cov ntshav qog ntshav tau tuaj yeem yog: insulin noj ntau dhau, hloov tshuaj, hla zaub mov, ntuav, raws plab, kev ntxhov siab ntawm lub cev, kab mob uas txo qis qhov xav tau ntawm insulin (mob raum thiab mob siab, nrog rau kev ua haujlwm ntawm adrenal cortex, pituitary lossis thyroid caj pas), hloov chaw txhaj tshuaj (piv txwv, tawv nqaij ntawm lub plab, xub pwg, ncej puab), ntxiv rau kev sib cuam tshuam nrog lwm yam tshuaj. Nws muaj peev xwm ua kom txo qis ntawm cov piam thaj hauv cov ntshav thaum hloov mus rau tus neeg mob los ntawm tsiaj insulin mus rau tib neeg cov insulin.

Tus neeg mob yuav tsum tau qhia paub txog cov tsos mob ntawm lub xeev hypoglycemic, txog thawj cov tsos mob ntawm tus mob ntshav qab zib tsis nco qab lawm thiab txog qhov yuav tsum tau qhia tus kws kho mob txog txhua yam kev hloov pauv hauv nws tus mob.

Thaum muaj ntshav qab zib, yog tias tus neeg mob nco qab, nws tau txiav txim siab dextrose sab hauv, s / c, iv lossis iv txhaj tshuaj glucagon lossis iv hypertonic dextrose tov. Nrog rau kev txhim kho lub ntsej muag tsis nco qab, 20-40 ml (txog 100 ml) ntawm 40% dextrose tov yog txhaj iv rau hauv qhov dej kom txog thaum tus neeg mob tawm ntawm lub cev tsis nco qab.

Cov neeg mob ntshav qab zib tuaj yeem nres cov ntshav qab zib kom tsawg uas lawv xav los ntawm kev noj cov piam thaj lossis zaub mov ntau hauv carbohydrates (cov neeg mob tau qhia tias ib txwm muaj tsawg kawg 20 g suab thaj nrog lawv).

Cawv kev haus dej haus cawv rau cov neeg mob tau txais cov tshuaj insulin yuav txo.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Qhov kev coj ntawm kev txhim kho hypoglycemia tej zaum yuav cuam tshuam lub peev xwm ntawm cov neeg mob tsav tsheb thiab ua haujlwm nrog cov twj.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv hypoglycemic yog txhim kho los ntawm sulfonamides (suav nrog qhov ncauj tshuaj hypoglycemic, sulfonamides), MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (suav nrog salicylides), anabolic (suav nrog stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, lithium npaj, pyridoxine, quinidine, quinine, chloroquin.

Glucagon, GCS, histamine H 1 receptor blockers, tshuaj tiv thaiv qhov ncauj, estrogens, thiazide thiab "voj" diuretics, qeeb calcium calcium blockers, sympathomimetics, thyroid hormones, tricyclic antidepressants, heparin, morphine diazropin txo cov nyhuv hypoglycemic. , tshuaj maj, nicotine, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine tuaj yeem ob leeg txhim kho thiab txo cov nyhuv hypoglycemic ntawm insulin.

Kev siv cov beta-blockers, clonidine, guanethidine lossis reserpine tib lub sijhawm tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib.

Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Muaj peb hom:

1. P - kev ua yeeb yam luv luv, xim xim thiab pob tshab.
2. C - nruab nrab ncua, ncua kev kawm ntawm cov xim dawb lossis milky.
3. M - sib tov 30/70, ob-theem. Nruab nrab nrog kev pib sai ntawm cov nyhuv, ncua kev kawm.

Muaj pes tsawg leeg suav nrog:

• 100 IU ntawm tib neeg kev tshuaj ntsuam genetic engineering insulin,
• tshuaj sulfate,
• sodium hydrogen phosphate dihydrate,
• crystalline phenol,
• metacresol
• glycerol (glycerin),
• dej rau kev txhaj tshuaj.

Excipients nyob rau hauv muaj pes tsawg leeg sib txawv me ntsis rau txhua hom. Rosinsulin M muaj cov tshuaj insulin biphasic - soluble + isophane.

Muaj nyob hauv hwj (5 daim ntawm 5 ml) thiab daim cartridges (5 daim ntawm 3 ml).

Cov Tshuaj Pharmacokinetics

Hom P pib ua ib nrab ib teev tom qab txhaj tshuaj, ncov - 2-4 teev. Ntev mus txog 8 teev.

Hom C yog qhib kom ua haujlwm tom qab 1-2 teev, qhov siab tshaj tshwm sim nruab nrab ntawm 6 thiab 12. Cov nyhuv xaus hauv ib hnub.

M pib ua haujlwm hauv ib nrab ib teev, qhov siab tshaj plaws yog 4-12, qhov kev txiav txim xaus rau 24 teev.

Nws yog rhuav tshem los ntawm insulinase hauv raum thiab mob siab. Nws yog tawm los ntawm lub raum. Tsuas yog txhaj tshuaj subcutaneous tau tso cai rau lawv tus kheej.

• Ob hom ntshav qab zib
• Mob ntshav qab zib rau cov poj niam cev xeeb tub,
• Cov kab mob sib kis
• Kev quav rau cov tshuaj hauv qhov ncauj hypoglycemic.

Cov lus qhia rau siv (qauv thiab ntau npaum li cas)

Txoj kev tseem ceeb ntawm kev tswj hwm yog kev txhaj tshuaj subcutaneous. Qhov ntau npaum tau yog xaiv ntawm tus kheej raws li cov lus pov thawj thiab cov kev xav tau ntawm lub cev. Qhov chaw txhaj tshuaj yog pob tw, lub duav, plab, xub pwg. Koj yuav tsum hloov pauv qhov chaw txhaj tshuaj.

Qhov nruab nrab cov tshuaj txhua hnub yog 0.5-1 IU / kg.

"Rosinsulin R" yog siv ib nrab ib teev ua ntej noj mov. Tus naj npawb ntawm kev txhaj tshuaj yog tus kws kho mob sau tseg.

Sab sij huam

• Kev tsis haum tshuaj hauv zos thiab cov kab ke,
• Kev Ntshav Qab Zib,
• Hnov tsis nco qab mus txog thaum tsis nco qab,
• BP txo qis
• Hyperglycemia thiab ntshav qab zib acidosis,
• Ib qho kev nce ntxiv ntawm titer ntawm cov tshuaj tiv thaiv insulin, tom qab los ntawm kev nce glycemia,
• Pom kev tsis pom kev
• Kev tiv thaiv kab mob nrog tib neeg cov tshuaj insulin,
• Hyperemia,
• Lipodystrophy,
• O o.

Noj ntau dhau

Tej zaum qhov kev txhim kho ntawm hypoglycemia. Nws cov tsos mob: kev tshaib kev nqhis, pallor, tsis hnov ​​qab nco qab rau tus tsis nco qab, xeev siab, ntuav thiab lwm tus. Daim ntawv foos tuaj yeem tshem tawm los ntawm kev noj cov zaub mov qab zib (khoom qab zib, ib qho qab zib, zib ntab). Hauv cov ntawv sim thiab hnyav, yuav tsum tau txhaj tshuaj glucagon lossis dextrose kev daws teeb meem, tom qab - noj mov nrog carbohydrates. Nco ntsoov tias tom qab ntawd sab laj tus kws kho mob rau kev hloov kho koob tshuaj.

Piv nrog analogues

Rosinsulin muaj ntau cov tshuaj zoo sib xws, uas nws yog qhov tsim nyog los paub koj tus kheej nrog piv rau cov yam ntxwv.

Novomiks. Insulin aspart, ob-theem. Tsim los ntawm Novo Nordisk hauv Denmark. Nqe - txog li 1500 rubles. rau kev ntim khoom. Cov nyhuv ntawm nruab nrab ntev, kuj ceev thiab zoo. Cov tshuaj tsis pub rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, thiab tau sau tseg nrog kev ceev faj thaum cev xeeb tub thiab laus. Ua xua rau ntawm qhov chaw txhaj tshuaj yog feem ntau sau tseg.

"Insuman." Neeg insulin, peb hom kev ua. Nws raug nqi ntawm 1100 rubles. Cov tsim tawm - "Sanofi Aventis", Fabkis. Nws yog siv rau kev kho mob ntawm ob tus neeg laus thiab menyuam yaus. Tsis tshua muaj tshwm sim phiv. Tus Thawj Coj Zoo.

"Protafan." Tsis tas li ntawd tib neeg cov kua dej yog ib hom kev ua kom caj. Pheej Yig - 800 rubles. rau cartridges, daws - 400 rubles. Tsim los ntawm Novo Nordisk, Denmark. Nws muab tshuaj tsuas yog subcutaneously, nws yog siv los kho cov neeg mob ntawm txhua lub hnub nyoog. Nws yog ua tau rau cov poj niam cev xeeb tub thiab lactating. Tus nqi pheej yig thiab pheej yig dua.

"Biosulin." Isulin cov kua dej. Chaw tsim tshuaj paus - Pharmstandard, Russia. Tus nqi yog kwv yees li 900 rubles. (cartridges). Nws yog kev ua haujlwm nrab-ncua sijhawm. Yuav siv tau los kho cov neeg mob ntawm txhua tus neeg.

Neeg lim hiam. Nws yog cov kua roj soluble tiv thaiv kev ua lag luam. Nqe - los ntawm 500 rubles. rau lub raj mis, cartridges yog ob zaug kim kim. Ob lub tuam txhab tsim cov tshuaj tam sim no - Eli Lilly, Tebchaws Asmeskas thiab Bioton, Poland. Siv rau tag nrho cov hnub nyoog, hauv cov poj niam cev xeeb tub muaj ntshav qab zib. Cov laus yuav tsum siv kom zoo. Muaj nyob hauv cov khw muag tshuaj thiab muaj txiaj ntsig zoo.

Kev txiav txim siab hloov tus neeg mob los ntawm ib hom tshuaj mus rau lwm qhov yog ua los ntawm tus kws kho mob uas koom nrog. Kev siv tus kheej yog txwv!

Yeej, cov neeg mob ntshav qab zib uas tau ua dhau los ntawm cov tshuaj no muaj lub tswv yim zoo. Yooj yim ntawm kev siv, muaj peev xwm los ua ke ob peb hom tau sau tseg. Tab sis muaj cov tib neeg uas cov tshuaj no tsis haum.

Galina: “Kuv nyob hauv Yekaterinburg, Kuv tau raug kho ntshav qab zib. Tsis ntev los no, Kuv tau txais Rosinsulin rau cov txiaj ntsig. Kuv nyiam cov tshuaj, zoo heev. Kuv thov luv thiab nruab nrab, txhua yam haum. Thaum kuv paub tias qhov no yog tshuaj ntsuab hauv tsev, ua rau kuv xav tsis thoob. Qhov zoo yog indistinguishable los ntawm txawv teb chaws ”.

Victor: “Protafan kho kuv. Tus kws kho mob qhia me ntsis kim kim ua cov tshuaj Lavxias-ua, Rosinsulin. Kuv tau siv nws tau ob peb lub hlis, Kuv zoo siab nrog txhua yam. Cov piam thaj tuav, tsis muaj kev phiv, tsis ua rau lub plawv tsis muaj ntshav qab zib. Tsis ntev los no, Kuv pib tau txais txiaj ntsig, uas nws tau txaus siab heev. "

Vladimir: “Siv“ Humalog ”thiab“ Humulin NPH. ” Hauv qee kis, lawv raug hloov los ntawm Rosinsulin rau cov txiaj ntsig. Kuv siv luv thiab nruab nrab. Txhawm rau qhia koj qhov tseeb, Kuv tsis tau pom tias muaj qhov sib txawv tshwj xeeb los ntawm cov tshuaj dhau los. Qab Zib yog OK, tsis muaj hypoglycemia. Txawm hais tias cov kev ntsuas tsom xam tau zoo dua. Yog li kuv qhia cov tshuaj no, tsis txhob ntshai tias nws yog Lavxias - khoom siv thiab raw khoom, raws li kuv tus kws kho mob tau hais, yog txawv teb chaws, txhua yam yog los ntawm cov qauv. Thiab qhov ua tau zoo dua. "

Larisa: “Tus kws kho mob pauv mus rau Rosinsulin. Nws tau kho rau ob peb lub hlis, tab sis maj mam qhov kev ntsuam xyuas tau los ua tsis zoo. Txawm noj haus los yeej pab tsis tau. Kuv yuav tsum tau hloov mus rau lwm txoj kev, tsis yog siv nyiaj, tab sis rau kuv cov nyiaj. Nws yog qhov ua rau poob ntsej muag, vim tias cov tshuaj pheej yig thiab zoo. "

Anastasia: “Sau npe muaj ntshav qab zib. Lawv muab Rosinsulin ua rau cov nyhuv nruab nrab los ua kev kho mob. Luv siv Actrapid. Kuv hnov ​​los ntawm lwm tus hais tias nws pab tau zoo, tab sis nyob hauv tsev kuv tseem tsis tau pom muaj kev hloov tshwj xeeb hauv lub xeev. Kuv xav thov tus kws kho mob hloov mus rau lwm cov tshuaj, vim tias tsis ntev los no tseem muaj qhov hawb mob hauv lub raum (hypoglycemia). Tej zaum nws tsis phim rau kuv, kuv tsis paub. "