Orlistat (Orlistat)

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yeeb OrlistatCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg siv khoom ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Orlistat hauv lawv cov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov cim qhia ntawm Orlistat nyob rau hauv muaj cov qauv txheej txheem qauv. Siv rau kev kho mob rog, rog thiab poob phaus hauv cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Orlistat - lipase inhibitor. Thaum noj ntawm qhov ncauj, orlistat inhibits gastric thiab pancreatic lipases. Raws li qhov tshwm sim, qhov tawg ntawm cov zaub mov hauv cov rog yog cuam tshuam thiab lawv qhov nqus ntawm qhov hnyuv tau txo. Nrog kev siv cov txheej txheem, cov nyhuv no ua rau txo lub cev qhov hnyav hauv cov neeg mob rog. Orlistat yog xyaum tsis tau nqus los ntawm txoj hnyuv thiab vim li cas thiaj tsis muaj qhov tshwm sim zoo.

Muaj pes tsawg leeg

Orlistat + cov neeg muaj peev xwm.

Cov Tshuaj Pharmacokinetics

Hauv cov neeg ua haujlwm pab dawb ua kom lub cev nyhav thiab rog dhau, cov kabmob ntsig txog cov tshuaj muaj tsawg heev. Tom qab ib qho kev sib tw ntawm qhov ncauj ntawm cov tshuaj ntawm qhov koob ntawm 360 mg, hloov pauv orlistat hauv ntshav tsis tuaj yeem txiav txim siab, uas txhais tau hais tias nws cov ntsiab lus ntau yog qis dua theem ntawm 5 ng / ml. Tsis muaj cov cim ntawm kev khaws zoo zuj zus, uas tshaj tawm tias qhov nqus ntawm cov tshuaj muaj tsawg heev. Tsawg tsawg zaus, orlistat tuaj yeem nkag mus rau cov ntshav liab. Kev txiav txim los ntawm cov ntaub ntawv tau los ntawm cov tsiaj sim, cov metabolism ntawm orlistat yog nqa tawm tsuas yog nyob hauv plab hnyuv phab ntsa. Cov kev tshawb fawb ntawm cov tib neeg muaj qhov hnyav thiab hnyav dua tau pom tias txoj kev tseem ceeb ntawm kev tshem tawm yog tshem tawm cov tshuaj tsis haum nrog quav. Nrog quav, kwv yees li 97% ntawm cov koob tshuaj uas tau lees txais yog raug tawm, nrog 83% hauv daim ntawv hloov pauv orlistat. Tag nrho lub raum kev ua haujlwm ntawm txhua yam tshuaj cuam tshuam nrog nrog orlistat tsawg dua 2% ntawm qhov koob tshuaj noj. Lub sijhawm ua kom tiav cov tshuaj tshem tawm ntawm lub cev (nrog quav thiab tso zis) yog li 3-5 hnub.

Cov Khoom Qhia

• Kev rog dhau los (ua ke nrog cov khoom noj muaj rog sib npaug).

Tso Tawm Cov Ntawv

Cov tshuaj ntsiav 120 mg (qee lub sijhawm hu ua yuam kev ntsiav tshuaj).

Cov lus qhia rau kev siv thiab regimen

Noj 120 mg qhov ncauj thaum lub sijhawm noj mov tseem ceeb lossis hauv ib teev tom qab noj mov, feem ntau tsis ntau tshaj 3 zaug hauv ib hnub. Yog tias koj cov khoom noj muaj roj tsawg, koj tuaj yeem hla tawm orlistat.

Sab sij huam

• roj tawm los ntawm qhov quav,
• flatulence
• tso pa tawm nrog qee yam kev paug tawm
• tsam plab
• oily cov quav (steatorrhea),
• nquag plob tsis so tswj
• qhov tseem ceeb yaum kom tso quav,
• quav txau.

Cov Yuav Tsum Muaj

• cov mob malabsorption mob ntev,
• cholestasis
• kev txo tshuaj rau Orlistat.

Cev xeeb tub thiab lactation

Orlistat yog siv nrog kev ceev faj thaum cev xeeb tub thiab lactation.

Hauv kev tshawb fawb ntawm kev ua me nyuam yaus muaj tshuaj lom hauv cov tsiaj, teratogenic thiab embryotoxic nyhuv ntawm cov tshuaj tsis tau pom. Thaum tsis muaj teratogenic siv rau hauv cov tsiaj, cov nyhuv zoo li tib neeg hauv tib neeg yuav tsum tsis txhob xav tias yuav.

Siv rau menyuam yaus

Cov lus qhia tshwj xeeb

Nws yuav tsum tau yug los hauv lub siab tias qhov ntau zaus thiab qhov loj ntawm cov kev mob tshwm sim nce nrog cov rog hauv cov zaub mov hauv cov zaub mov. Nrog rau qhov ua kom cov rog hauv cov zaub mov txo qis, qhov ntxim nyiam yuav tshwm sim yog tshwm sim ntau dua. Nws raug nquahu tias cov rog noj haus ib hnub twg yog cov ncaj ncees faib rau txhua cov zaub mov.

Thaum kho, raws li lub cev hnyav poob, nws muaj peev xwm txhim kho cov chav kawm ntawm cov txheej txheem pathological feem ntau cuam tshuam nrog kev rog, suav nrog arterial hypertension, mob ntshav qab zib mellitus, lipid metabolism ntshawv siab.

Yeeb tshuaj sib cuam tshuam

Orlistat tau pom tias yuav txo qis kev nqus tawm ntawm txoj hnyuv plab ntawm betacarotene, alpha-tocopherol.

Tsis muaj kev cuam tshuam nrog amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, qhov ncauj tiv thaiv kab mob, phentermine, pravastatin, warfarin, nifedipine GITS (kev kho dej cawv-raws li lub plab zom mov) lossis nibbutin ntawm cov tshuaj). Txawm li cas los xij, nws yog qhov yuav tsum tau soj ntsuam kev ua haujlwm ntawm MNO nrog kev kho mob concomitant nrog warfarin lossis lwm yam tshuaj tiv thaiv qhov ncauj.

Nrog rau kev tswj hwm tib txhij ntawm orlistat thiab cov tshuaj tiv thaiv kab mob, cov xwm txheej ntawm kev txhim kho ntawm qaug dab peg tau pom. Lub hauv paus ua rau kev sib raug zoo ntawm kev txhim kho kev chua leeg lossis orlistat kev kho mob tsis tau txhim tsa. Txawm li cas los xij, cov neeg mob yuav tsum tau txais kev soj ntsuam kom muaj kev hloov pauv hauv zaus thiab / lossis mob hnyav ntawm cov mob huam mob hlwb.

Analogs ntawm cov tshuaj Orlistat

Cov qauv ntawm cov qauv ua haujlwm:

• Allie
• Xenalten
• Xenalten Teeb,
• Xenalten Slim,
• Xenical
• Teev npe
• Teev Npe Mini,
• Orlimax
• Orlimax Teeb,
• Orlistat Canon
• Orsoten
• Orsotin Slim.

Analogs rau cov nyhuv kho (cov nyiaj los kho kev rog):

• Aknekutan,
• Cov kab mob sib npaug
• Cov roj av blocker
• Garcilin
• Garcinia forte
• Kub kub
• Noj Kev Nyob Zoo
• Noj zaub mov txawv,
• Kev noj haus
• Ntuj dietrin,
• Dr. Theiss Nova Daim Duab,
• Lub tswv yim
• Coenzyme Q10 nrog Ginkgo,
• Lamisplat
• Lindax,
• Magnesium Complex,
• Meridia
• Metformin
• Mukofalk,
• Normoflorin
• Oxodoline,
• Orsoslim
• Reduxin
• Polysorb
• Sibutramine,
• Cov quav,
• Slim Ntxiv,
• Trimex,
• Phenotropil,
• Figurin
• Fitolaks,
• Phytomucil,
• Hoodia Lub Neej,
• Hoodia Slim
• Citrimax Plus Noj mis nyuj,
• Citrosept
• Suav Yaj.

Pharmacological pawg

Cov Tshuaj Hauv Tshuaj

Ib qho tshwj xeeb inhibitor ntawm lub plab hnyuv lipases. Nws daim ntawv cog lusal covalent nrog cov nquag serine thaj av ntawm lub plab thiab pancreatic lipases hauv qhov lumen ntawm lub plab thiab cov hnyuv. Qhov inactivated enzyme poob nws lub peev xwm los tsoo cov rog zaub mov hauv daim ntawv ntawm triglycerides (TG). Kev siv TG uas tsis tau txais kev pab tsis raug nqus, thiab qhov tshwm sim hauv kev txo qis hauv calorie ua rau lub cev hnyav dua. Nce lub concentration ntawm rog nyob rau hauv cov quav 24-4 teev tom qab kev noj mov. Muab cov kev tswjhwm zoo ntawm lub cev nyhav, txo cov rog rog.

Rau qhov kev ua kom paub, kev ua kom tsis haum los ntawm orlistat tsis yog; nyob rau hauv cov tshuaj kho pom zoo (120 mg 3 zaug hauv ib hnub), nws inhibits kev nqus ntawm cov khoom noj uas tau los ntawm kwv yees li 30%.

Cov Tshuaj Pharmacokinetics

Kev nqus tau qis tsawg, 8 teev tom qab noj, tsis hloov pauv orlistat hauv ntshav tsis tau txiav txim siab (kev tsom rau hauv qab 5 ng / ml).

Qhov kev tiv thaiv kab mob thoob plaws ntawm orlistat yog qhov tsawg heev. Tom qab noj ntawm 360 mg ntawm radioactively daim ntawv lo 14 C-orlistat, lub ncov hluav taws xob ntau hauv plasma tau mus txog tom qab li 8 teev, qhov tseem ceeb ntawm tsis hloov pauv orlistat yog ze rau qhov kev txiav txim siab (tsawg dua 5 ng / ml). Hauv kev tshawb nrhiav kho, uas suav nrog kev saib xyuas ntshav ntshav ntawm cov neeg mob, kev hloov pauv orlistat tau txiav txim siab nyob rau hauv ntshav, thiab nws cov ntsiab lus tsawg tsawg (tsawg dua 10 ng / ml), tsis muaj cov cim ntawm tsub zuj zuj, uas zoo ib yam nrog kev nqus tsawg ntawm cov tshuaj.

Hauv vitro orlistat ntau tshaj 99% khi rau cov protein ntshav, feem ntau yog siv lipoproteins thiab albumin. Orlistat minimally nkag mus rau cov ntshav liab. Nws yog metabolized feem ntau nyob hauv phab ntsa ntawm txoj hnyuv nrog qhov tsim ntawm pharmacologically tsis muaj zog metabolites M1 (hydrolyzed plaub-membered lactone nplhaib) thiab M3 (M1 nrog cleaved N-formylleucine residue). Hauv kev tshawb fawb txog cov neeg mob rog rog uas tau noj 14 C-orlistat, 2 metabolites, M1 thiab M3, kwv yees li ntawm 42% ntawm tag nrho cov plasma radioactivity. M1 thiab M3 muaj qhib lub nplhaib beta-lactone thiab ua rau pom kev ua kom tsis muaj zog tiv thaiv kev ua haujlwm tiv thaiv lipases (piv rau orlistat, lawv yog 1000 thiab 2500 zaug tsis muaj zog, feem). Muab cov haujlwm qis thiab tsis tshua muaj siab ntawm plasma metabolites (txog 26 ng / ml thiab 108 ng / ml rau M1 thiab M3, ntsig txog, 2–4 teev tom qab noj orlistat hauv tshuaj kho mob), cov metabolites no suav hais tias yog cov tshuaj tsis tseem ceeb. Lub ntsiab metabolite M1 muaj lub luv T_1/2 (txog 3 teev), lub cev qhov kev tiv thaiv kab mob thib ob tau tawm qeeb dua (T_1/2 - 13,5 teev). Hauv Kev Rog Rau Cov Neeg Mob C_ss metabolite M1 (tab sis tsis M3) nce nyob rau hauv kev faib ua feem rau cov koob tshuaj ntawm orlistat. Tom qab ib qho kev tswj hwm qhov ncauj ntawm 360 mg ntawm 14 C-orlistat los ntawm cov neeg mob uas lub cev muaj qhov hnyav thiab kev txom nyem los ntawm kev rog, qhov kev tso tawm ntawm tsis yog-absorbable orlistat los ntawm txoj hnyuv yog qhov tseem ceeb ntawm kev nthuav dav. Orlistat thiab nws cov metabolites M1 thiab M3 kuj tseem ua nrog cov kua tsib. Kwv yees li ntawm 97% ntawm cov xov tooj cua tau muab tshuaj yeeb dej caw raug tso quav nrog quav, suav nrog 83% - pauv tsis tau.

Tag nrho lub raum zoo li cas ntawm tag nrho cov xov tooj cua nrog 360 mg ntawm 14 C-orlistat tsawg dua 2%. Lub sijhawm rau kev tshem tawm ua tiav nrog quav thiab tso zis yog 3-5 hnub. Kev tshem tawm ntawm orlistat tau pom zoo ib yam nkaus rau cov neeg mob lub cev nyhav thiab rog dhau. Raws li cov ntaub ntawv tsis tshua muaj, T_1/2 nqus orlistat yog hom twg los ntawm 1-2 teev.

Kev taw qhia ntawm cov tshuaj Orlistat

kho kev rog, suav nrog kev txo thiab kev saib xyuas lub cev nyhav, ua ke nrog kev noj zaub mov tsis muaj calorie,

txo qhov txaus ntshai kom rov ua kom lub cev hnyav dua tom qab nws txo qis.

Orlistat yog qhia rau cov neeg mob rog rog lub cev ntsuas ntawm lub cev (BMI) ntawm ≥30 kg / m 2 lossis ≥28 kg / m 2 thaum muaj lwm yam kev pheej hmoo (ntshav qab zib, kub siab, dyslipidemia). (Muab xam los ntawm BMI: BMI = M / P 2, qhov twg M - lub cev nyhav, kg, P - qhov siab, m.)

Cev xeeb tub thiab lactation

Orlistat yog contraindicated thaum cev xeeb tub vim tsis muaj cov ntaub ntawv kho mob txhim khu kev qha lees paub txog kev nyab xeeb ntawm nws siv.

Nws tseem tsis tau tsim muaj los hais tias orlistat kis mus rau niam mis, thiab yog li ntawd kev siv Xenalten ® lub sijhawm pub mis.

Sab sij huam

Qhov ntau zaus ntawm cov kev mob tshwm sim hauv qab no tau txiav txim siab raws li cov hauv qab no: feem ntau (> 1/10), feem ntau (> 1/100, 1/1000, 1/10000, GIT: ntau zaus - muaj roj tawm ntawm lub qhov quav, roj nrog qhov tso tawm ntawm lub cev, qhov tseem ceeb txhawb kom tso quav, tso quav, tso quav ntau zaus, tso quav, xaim quav, mob plab lossis mob lub plab.

Raws li txoj cai, cov kev phiv tshuaj tsis zoo yog me thiab dhau los, tshwm sim thaum ntxov ntawm kev kho mob (hauv thawj 3 lub hlis). Qhov ntau zaus ntawm cov kev phiv tshuaj no muaj ntau ntxiv nrog cov ntsiab lus rog hauv cov zaub mov noj. Cov neeg mob yuav tsum tau qhia paub txog qhov ua tau ntawm qhov tshwm sim tsis zoo no thiab qhia tias yuav ua li cas tshem tawm lawv los ntawm kev noj zaub mov kom zoo dua, tshwj xeeb tshaj yog cuam tshuam nrog cov roj hauv nws. Feem ntau - cov quav muag, mob lossis tsis xis nyob ntawm lub qhov quav, quav dej quav cawv, tsam plab, ua kom hniav puas, pos hniav mob.

Los ntawm lub tshuab ua pa, hauv siab thiab mediastinal kabmob: feem ntau sab sauv ntawm txoj hlab ua pa, feem ntau txo qis tus kab mob ua pa.

Los ntawm lub nruab zog: tsis tshua muaj - khaus, urticaria, tawm pob, angioedema, bronchospasm, anaphylaxis.

Los ntawm lub paj hlwb: heev heev - mob taub hau.

Nyob rau ib feem ntawm daim siab thiab kais plab: tsawg kawg - kev ua si ntau ntxiv ntawm transaminases thiab alkaline phosphatase, kab mob siab.

Los ntawm ob lub raum thiab mob txeeb zig: feem ntau tso zis mob txeeb zig.

Lwm yam: heev - khaub thuas, ntau zaus - dysmenorrhea, ntxhov siab vim, tsis muaj zog.

Yog tias muaj kev phiv dab tsi nyob rau hauv cov lus qhia yog hnyav dua lossis lwm cov phiv uas tsis muaj npe hauv cov lus qhia raug pom, koj yuav tsum qhia koj tus kws kho mob.

Kev sib txuam

Orlistat tsis cuam tshuam rau lub pharmacokinetics ntawm ethanol, digoxin (tshuaj hauv ib qho tshuaj) thiab phenytoin (tshuaj hauv ib koob ntawm 300 mg), lossis bioavailability ntawm nifedipine (kev txhawb nqa tawm ntsiav tshuaj). Ethanol tsis cuam tshuam rau pharmacodynamics (rog dhau nrog cov quav) thiab lub cev raug orlistat.

Nrog rau kev siv orlistat thiab cyclosporine tib lub sij hawm, theem ntawm cov tom kawg hauv cov ntshav txo qis (orlistat thiab cyclosporine yuav tsum tsis txhob noj ib txhij, txhawm rau txo qhov muaj feem ntawm kev sib txuam tshuaj, cyclosporine yuav tsum noj 2 teev ua ntej lossis 2 teev tom qab noj orlistat).

Nrog rau kev siv tib lub sij hawm ntawm warfarin lossis lwm qhov anticoagulants nrog orlistat, qib ntawm prothrombin yuav txo qis thiab tus nqi ntawm INR qhov ntsuas tuaj yeem hloov pauv, yog li INR saib xyuas yog qhov tsim nyog. Orlistat txo qhov kev nqus ntawm beta-carotene hauv kev noj zaub mov noj haus los ntawm 30% thiab inhibits qhov nqus ntawm cov vitamin E (hauv daim ntawv ntawm tocopherol acetate) kwv yees li 60%.

Nws nce lub bioavailability thiab hypolipidemic nyhuv ntawm pravastatin, ua rau nws cov tshuaj plasma ntau ntxiv los ntawm 30%.

Nrog rau kev tswj hwm tib lub sijhawm nrog orlistat, qhov nqus ntawm cov vitamins A, D, E thiab K raug txo qis.Yog cov multivitamins pom zoo, yuav tsum noj tsawg kawg 2 teev tom qab noj Xenalten ® lossis ua ntej mus pw.

Kev hnyav lub cev tuaj yeem txhim kho cov metabolism hauv cov neeg mob ntshav qab zib mellitus, vim qhov kev txiav txim siab nws yog qhov tsim nyog los txo cov koob tshuaj ntawm qhov ncauj hypoglycemic tshuaj.

Kev siv tib txhij ntawm acarbose tsis pom zoo vim tias tsis muaj cov ntaub ntawv ntawm kev sib txuam pharmacokinetic. Nrog rau kev siv ua ke nrog orlistat, qhov txo qis ntawm amiodarone hauv ntshav ntxiv tom qab ib koob tau muab sau tseg. Kev siv orlistat thiab amiodarone ib txhij siv tsuas yog nyob ntawm kev pom zoo los ntawm kws kho mob.

Orlistat tej zaum yuav tsis ncaj ncaj rau kev txo qis kev noj qab haus huv ntawm lub qhov ncauj, uas tuaj yeem ua rau txoj kev loj hlob ntawm qhov tsis xav xeeb tub. Nws raug nquahu kom siv ntxiv ntawm kev tswj kom muaj me nyuam nyob rau hauv cov ntaub ntawv ntawm mob raws plab.

Cov chaw sib tham tseem ceeb nrog digoxin, amitriptyline, phenytoin, fluoxetine, sibutramine, atorvastatin, pravastatin, losartan, glibenclamide, qhov ncauj tawm tsam, nifedipine, furosemide, captopril, atenolol thiab ethanol tsis sau tseg.

Noj ntau dhau

Cov teeb meem ntawm kev haus dej ntau dhau tsis piav qhia.

Koob tshuaj ib zaug 800 mg ntawm orlistat lossis nws cov ntau lub sijhawm txog li 400 mg 3 zaug hauv ib hnub rau 15 hnub los ntawm cov neeg muaj lub cev nyhav thiab nrog kev rog tsis tau nrog cov kev mob tshwm sim ntau.

Yog tias pom qhov noj ntau dhau ntawm orlistat, tus neeg mob yuav tsum tau saib xyuas li 24 teev. Raws li kev tshawb fawb hauv tsiaj thiab tib neeg, cov teebmeem cuam tshuam nrog cov lipase-inhibiting cov khoom ntawm orlistat yuav tsum tau hloov mus sai.

Cov lus qhia tshwj xeeb

Thaum lub sijhawm kev kho mob, nws yog ib qho tsim nyog yuav tsum ua raws cov khoom noj muaj roj, muaj lub cev tsawg uas tsis muaj ntau tshaj 30% calorie ua rau cov rog thiab ntxiv nrog txiv hmab txiv ntoo thiab zaub.

Ua ntej sau ntawv tawm orlistat, cov organic ua rau kev rog, xws li hypothyroidism, yuav tsum raug txiav txim siab.

Qhov ntxim nyiam ntawm kev phiv los ntawm cov hnyuv nce ntxiv nrog cov ntsiab lus ntawm cov rog hauv cov zaub mov (ntau dua 30% ntawm cov calories txhua hnub). Kev noj txhua hnub ntawm cov rog, carbohydrates thiab cov protein yuav tsum tau muab faib nruab nrab ntawm peb cov zaub mov tseem ceeb. Txij li orlistat txo qhov kev nqus ntawm qee cov vitamins-fat soluble, cov neeg mob yuav tsum noj multivitamin npaj muaj cov vitamins-soluble vitamins kom paub meej tias lawv tau txais txaus. Ntxiv rau, cov ntsiab lus ntawm cov vitamin D thiab beta-carotene hauv cov neeg mob rog rog tuaj yeem yuav qis dua li cov neeg tsis rog. Multivitamins yuav tsum noj 2 teev ua ntej lossis 2 teev tom qab noj orlistat, piv txwv li, ua ntej yuav mus pw. Hauv cov neeg mob uas tsis tau txais kev txhawb nqa cov tshuaj vitamin, thaum lub sijhawm ob lossis ntau zaus mus ntsib kws kho mob thaum thawj xyoo thiab xyoo thib ob ntawm kev kho mob nrog orlistat, ib qho kev poob qis hauv cov vitamins hauv plasma raug sau cia. Txij li thaum nqus cov vitamin K thaum noj orlistat tej zaum yuav muaj tsawg zuj zus, hauv cov neeg mob tau txais orlistat tiv thaiv keeb kwm ntawm kev ncua ntev ntawm kev noj warfarin, ntshav cov ntshav coagulation yuav tsum tau saib xyuas.

Txais tos ntawm orlistat hauv koob tshuaj ntau dua 120 mg 3 zaug ib hnub tsis muab cov nyhuv ntxiv.

Yog tias kev tswj hwm ib txhij ntawm orlistat nrog cyclosporine tsis tuaj yeem zam, kev saib xyuas txuas ntxiv ntawm cov ntsiab lus cyclosporin hauv cov ntshav yog tsim nyog.

Hauv qee tus neeg mob, tawm tsam cov keeb kwm ntawm orlistat, cov ntsiab lus ntawm oxalates hauv cov zis yuav nce ntxiv. Ib yam li lwm yam tshuaj los txo qhov hnyav hauv lub cev, hauv qee pab pawg ntawm cov neeg mob (piv txwv li, nrog anorexia nervosa lossis bulimia), muaj qhov ntxim nyiam ntawm kev tsim txom ntawm orlistat.

Orlistat induction ntawm kev poob phaus tuaj yeem ua ke nrog kev txhim kho metabolic tswj ntshav qab zib mellitus, uas yuav xav tau koob tshuaj qis dua ntawm qhov ncauj hypoglycemic (sulfonylurea derivatives, metformin) lossis insulin. Yog tias, tom qab 12 lub lis piam ntawm kev kho mob nrog Xenalten ®, qhov txo lub cev qhov hnyav tsawg dua 5% ntawm qhov qub, tus kws kho mob yuav tsum tau sab laj los txiav txim siab seb puas yuav tsum tau kho ntxiv nrog orlistat.

Txoj kev kho yuav tsum tsis pub ntev tshaj 2 xyoos.

Xenalten ® tsis yog siv rau kev xyaum tsiaj txhu.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab kev pabcuam txav chaw. Nws tsis cuam tshuam rau qhov muaj peev xwm tsav tsheb thiab tswj kev siv lub tshuab txav.

Cov lus qhia rau kev siv Orlistat, ntau npaum li cas

Cov tshuaj ntsiav tau noj ntawm qhov ncauj thaum noj mov, ntxuav nrog dej. Cov lus qhia rau kev siv Orlistat pom zoo kom noj tshuaj 3 zaug hauv ib hnub, thaum ua ib pluas mov loj.

Hauv rooj plaub thaum cov zaub mov tsis muaj roj, koj tuaj yeem hla kev noj tshuaj.

Cov lus qhia tshwj xeeb

Txhawm rau kom muaj txiaj ntsig zoo ntawm txhua yam khoom noj haus, nws raug nquahu kom noj cov tshuaj multivitamins (noj tsawg kawg 2 teev tom qab noj tshuaj lossis thaum mus pw).

Tus neeg mob yuav tsum pom zoo kom noj cov zaub mov muaj roj tsawg, vim tias qhov tshwm sim muaj feem los ntawm kev mob plab hnyuv tuaj yeem nce ntxiv yog tias Orlistat noj thaum noj cov zaub mov uas muaj cov rog muaj roj ntau (piv txwv, 2000 kcal / hnub, uas ntau dua 30% yog nyob rau hauv daim ntawv ntawm cov rog, uas sib haum kwv yees li 67 g )

Sab sij huam

Cov kev qhia ceeb toom pom tau tias yuav muaj peev xwm tsim cov kev mob tshwm sim hauv qab no thaum muab tshuaj Orlistat:

• Oily tawm los ntawm qhov quav,
• Flatulence
• Kev tso tawm roj av nrog qee qhov nqi ntawm tawm,
• Los ntshav
• Steatorrhea
• Nquag nquag plob tsis so tswj
• Tseem ceeb kom tso quav,
• Tsis nco qab.

Cov Yuav Tsum Muaj

Orlistat yog contraindicated nyob rau hauv cov nram no:

• Cholestasis
• Malabsorption syndrome,
• Tsis txog 18 xyoo
• Cev xeeb tub thiab pub niam mis,
• Siv yooj yim nrog cyclosporine,
• Hypersensitivity rau ib yam ntawm cov tshuaj.

Sau ntawv nrog kev ceev faj:

• Nephrolithiasis (muaj cov calcium oxalate pob zeb),
• Keeb kwm ntawm hyperoxaluria.

Noj ntau dhau

Overdose, raws li txoj cai, yog pom los ntawm kev phiv los ntawm txoj hnyuv hauv plab. Nws yog ib qho tsim nyog los soj ntsuam tus neeg mob, kev kho mob cov tsos mob.

Cov cim qhia ntawm Orlistat, tus nqi hauv cov khw muag tshuaj

Yog tias tsim nyog, hloov Orlistat, qhov no tuaj yeem ua tiav nrog ib qho analogue ntawm cov tshuaj nquag - tshuaj:

Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Orlistat, nqe thiab kev txheeb xyuas tsis siv rau cov tshuaj ntawm cov nyhuv zoo sib xws. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Nqe hauv khw muag tshuaj Lavxias: Orlistat 60 mg 42 tsiav tshuaj - los ntawm 430 txog 550 rubles, 120 mg 42 tsiav tshuaj - los ntawm 1048 txog 1200 rubles, raws li 793 lub tsev muag tshuaj.

Khaws tawm ntawm qhov ncav cuag cov menyuam yaus, tiv thaiv los ntawm lub teeb thiab ya raws, ntawm qhov kub tsis tshaj 25 ° C. Txee lub neej yog 2 xyoos.

Qhov xwm txheej ntawm kev faib tawm los ntawm cov khw muag tshuaj yog los ntawm cov tshuaj noj.

4 kev txheeb xyuas rau “Orlistat”

Siv li ib nrab xyoo Orlistat. Thaum lub sijhawm no, nws poob 28 kg. Thaum xub thawj kuv raug tsim txom los ntawm kev tso quav, thiab tom qab ntawd kuv ua siab ntev rau cov tshuaj ib txwm. Yuav kom yuag poob kom zoo, ntawm chav kawm, Kuv ua raws kev noj haus. Rau ib hnub - tsis pub ntau tshaj 1200 kcal.

Yog tias koj tsis noj cov rog, ces koj tsis tas yuav siv cov tshuaj no. Nws yuav tsis tshem koj tus kheej cov rog, nws yuav tshem tawm qhov uas noj.

Kuv poob ceeb thawj, thiab ho. Thawj lub hlis yog li 8kg ... tom qab ntawd txog 5 ... Kuv yuav tsis dag nyob rau hauv grams thiab tsis suav suav hnub. Qhov loj tshaj plaws yog zam lub limtiam thawj zaug thiab noj cov vitamins.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm tsiav tshuaj: loj No. 1, gelatin nyuaj, lub cev thiab lub hau yog xiav, cov ntsiab lus ntawm cov tshuaj ntsiav yuav luag tag nrho cov xim dawb los yog dawb (7 lossis 21 pcs. Hauv cov hlwv, hauv daim duab los qhia 1, 2, 3, 4, 6 , 12 pob).

1 tshuaj ntsiav muaj:

• cov tshuaj nquag: orlistat - 120 mg,
• cov khoom siv ntxiv: sodium carboxymethyl hmoov txhuv nplej siab (sodium starch glycolate), microcrystalline cellulose, povidone, talc, sodium lauryl sulfate,
• plhaub: titanium dioxide (E171), gelatin, zas xiav patented.

Kev ntsuas rau siv

• kev kho mob ntawm kev rog, suav nrog kev ua kom txo qis thiab kev saib xyuas lub cev qhov hnyav, ua ke nrog kev noj zaub mov kom yuag,
• txo qhov kev hem thawj ntawm kev rov ua kom lub cev hnyav dua tom qab ncav nws qhov pib txo qis.

Cov tshuaj no raug pom zoo rau cov neeg mob rog rog nrog lub cev ntsuas lub cev (BMI) ≥ 30 kg / m² lossis cov neeg mob uas muaj BMI ≥ 28 kg / m of nyob rau ntawm qhov muaj rog rog cuam tshuam nrog kev pheej hmoo rog xws li arterial hypertension, dyslipidemia, thiab ntshav qab zib mellitus.

Kev suav ntawm BMI yog nqa tawm raws li cov qauv hauv qab no: M (M - lub cev qhov hnyav hauv kg) / P 2 (P - qhov siab hauv m).

Cov Yuav Tsum Muaj

• cholestasis
• malabsorption syndrome,
• hnub nyoog txog 18 xyoo
• cev xeeb tub thiab pub niam mis,
• siv cov khoom xa hluav taws xob nrog cyclosporine,
• muaj qhov tsis haum xeeb rau ib qho twg ntawm cov yeeb tshuaj.

Tus txheeb ze (siv nrog ceev faj):

• nephrolithiasis (muaj cov calcium oxalate pob zeb),
• keeb kwm ntawm hyperoxaluria.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, noj Orlistat yog contraindicated, txij li tsis muaj cov ntaub ntawv pov thawj kev ntseeg tau lees paub qhov kev nyab xeeb ntawm nws siv hauv cov poj niam cev xeeb tub.

Nws tsis paub meej tias cov tshuaj puas tawm hauv tib neeg cov kua mis, yog li nws yog contraindicated yuav siv cov tshuaj thaum lactation.

Yeeb tshuaj sib cuam tshuam

• phenytoin, amitriptyline, digoxin, sibutramine, fluoxetine, losartan, pravastatin, atorvastatin, tshuaj tiv thaiv qhov ncauj, glibenclamide, furosemide, nifedipine, ethanol, atenolol, captopril - tsis muaj kev cuam tshuam loj hauv kev kho mob nrog orlistist pom
• ethanol, phenytoin (ntawm koob tshuaj 300 mg), digoxin (siv nyob rau hauv ib koob) - lub pharmacokinetics ntawm cov tshuaj tsis hloov, qhov cuam tshuam ntawm ethanol ntawm cov tshuaj tiv thaiv muaj kabmob thiab pharmacodynamics (kev zam ntawm cov rog nrog quav) ntawm orlistat tsis pom,
• nifedipine (nyob rau hauv daim ntawv ntawm tsim koob tshuaj tso tawm) - lub bioavailability ntawm cov tshuaj tsis hloov,
• cyclosporin - nws cov plasma qib qis, koj yuav tsum tsis txhob noj cov tshuaj no tib lub sijhawm, yog tias tsim nyog, kev sib xyaw ntawm cyclosporine pom zoo kom siv 2 teev ua ntej lossis tom qab noj orlistat (kev soj ntsuam tas mus li ntawm qib cyclosporine hauv ntshav yog tsim nyog),,
• acarbose - tsis muaj cov ntaub ntawv hais txog kev sib txuam pharmacokinetic, kev siv txhij ib zaug tsis pom zoo,
• amiodarone - nrog rau kev sib xyaw ua ke no, qhov kev txo qis ntawm cov ntshav ntawm amiodarone yog sau tseg, koob tshuaj sib xyaw nrog orlistat yog ua tau tsuas yog qhia los ntawm tus kws kho mob,
• cov tshuaj tiv thaiv tsis ncaj (suav nrog warfarin) - nws yog qhov muaj peev xwm txo qis ntawm prothrombin thiab hloov tus nqi ntawm qhov ntsuas ntawm qhov ntsuas thoob ntiaj teb (INR), raws li qhov no, kev saib xyuas ntawm INR yog qhov yuav tsum tau ua
• beta-carotene - nws txoj kev nqus nws yog txo los ntawm 30%,
• pravastatin - ua rau kom cov ntshav plasma qhov ntau zuj zus (los ntawm 30%) thiab bioavailability, uas ua rau cov lipid-txo cov nyhuv tsawg dua,
• Vitamin E (nyob rau hauv daim ntawv ntawm tocopherol acetate) - nws txoj kev nqus nws txo los txog li 60%,
• cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj (sulfonylurea / metformin derivatives), insulin - nws yuav tsum tau txo cov tshuaj no ntau vim tias muaj kev txhim kho hauv cov metabolism hauv cov neeg mob ntshav qab zib mellitus,
• qhov ncauj tiv thaiv tsis haum - nws muaj peev xwm los txo lawv txoj kev noj qab haus huv (vim yog qhov tsis ncaj ntawm orlistat), tawm tsam keeb kwm ntawm mob plab, nws raug nquahu kom siv ntau hom kev tiv thaiv.

Cov qauv ntawm Orlistat yog: Listata Mini, Orsoten, Listata, Xenalten Slim, Orsoten Slim, Xenical, Xenalten Logo, Orliksen 120, Orliksen 60, Alli, Xenalten Teeb.

Kev txheeb xyuas ntawm Orlistat

Cov neeg mob noj tshuaj tawm feem ntau yog tshuaj xyuas txog Orlistat. Ntau tus sau tseg tias tom qab ib txoj kev kho lawv tswj kom txo qhov poob phaus, thaum tsis muaj qhov tshwj xeeb tshwm sim ntawm kev phiv tshuaj ntawm cov tshuaj. Cov tshuaj, raws li kev txheeb xyuas, ua qeeb qeeb tab sis stably, tso cai rau koj kom poob 10 kg ntawm qhov hnyav hauv kwv yees li rau lub hlis. Cov neeg mob tseem pom zoo tias thaum lub sijhawm noj tshuaj, nco ntsoov kho tus cwj pwm noj mov kom zoo thiab xaiv txoj haujlwm kom raug rau kev tiv thaiv kev rog rog nyob rau hauv kev saib xyuas ntawm tus kws tshaj lij.

Txawm li cas los xij, tseem muaj kev tshuaj xyuas txog cov neeg mob tsis txaus siab, uas qhia tau tias lub txiaj ntsig tsis txaus ntawm kev siv tshuaj lossis qhov tsis tuaj ntawm qhov ua tiav tau zoo los ntawm kev kho. Kuj tseem muaj qee qhov kev tsis txaus siab txog kev txhim kho ntawm qhov tsis txaus siab ntawm orlistat, raws li txoj cai, nyob rau hauv daim ntawv ntawm lub plab tsis xis nyob, pom tsis meej, tsis quav ntsej cov quav xoob xoob, thiab qaug zog ntau dhau. Nws tau sau tseg tias qhov tshwm sim ntawm kev tshwm sim loj heev hauv qee kis tau ua rau cov tshuaj txuas ntxiv.