Cov Tshuaj Tiv Thaiv Clindamycin: cov lus qhia rau kev siv

Clindacin, suav nrog raws li kev ua kom muaj khoom xyaw lincosamide tshuaj tua kab mob – clindamycinyog qhov kev kho mob hauv zos siv hauv kev kho mob poj niam txiv neej rau kev kho mob ntawm gardnerellosis (vaginosis) ntawm keeb kwm kab mob. Cov txheej txheem ntawm kev txiav txim ntawm cov ntawv hauv zos ntau ntawm cov tshuaj (qab zib, suppositories) yog tsom rau kev cuam tshuam cov txheej txheem ntawm cov tshuaj protein intracellular hauv microbial cell, uas tshwm sim nyob rau theem ntawm 50S ribosomal subunit.

Kev ua spectrum clindamycin dav txaus. Hauv nruab nrab cov koob tshuaj, cov kab mob bacteriostatic ua haujlwm ntawm cov tshuaj muaj feem rau ntau cov kab mob me meCov. Hauv kev siv tshuaj ntau dua clindamycin tsiag ntawv los ntawm kev kho tus kab mob tsom rau kev rhuav tshem qee leej cov kab mob lim ntshav.

Cov haujlwm tseem ceeb clindamycin pom nyob rau hauv kev sib raug zoo rau cov kab mob me meua rau kev tsim cov kab mob vaginosissuav nrog: Mobiluncus spp. (tsim txiaj) Gardnerella vaginalis (gardnerella vaginalis) Bacteroides spp. (Cov tshuaj tiv thaiv) Peptostreptococcus spp. (peptostreptococcus) Mycoplasma hominis (mycoplasma hominis).

Insensitive raug clindamycin yog leeg leeg Candida albicans (xyaug) thiab Trichomonas vaginalis (trichomonas paum).

Intravaginal (sab hauv lub qhov chaw mos) ib qho txhaj tshuaj ntawm clindamycin ntawm ib koob ntawm 100 mg ua rau kev nqus tshuaj ntawm lub cev yog li ntawm 4% ntawm cov tshuaj (kwv yees li 4 mg). Lub plasma Cmax ntawm clindamycin yog 20 ng / ml.

Sab sij huam

Qee tus neeg mob nrog kev siv clindacin tau hnov qhov kev loj hlob ntawm cov kev mob tshwm sim tsis zoo, suav nrog: khaus hauv qhov chaw moskev kawm maculopapular pobmuaj tshwm sim urticariakev txhim kho mob ncauj tsev menyuam lossis colpita (mob chaw mos) vulvovaginal vooskev xav hlawv.

Los ntawm cov kab mob hematopoietic hauv cov neeg tsis tshua muaj, cov hauv qab no tau pom: thrombocytopeniathim rov qab leukopenia, eosinophilia, neutropenia, agranulocytosis.

Nyob rau hauv cov ntaub ntawv ntawm tseem ceeb systemic nqus ntawm clindamycin, ib tug manifestation ntawm nws xam qhovkev mob tshwm sim yog ua tau, nrog rau kev tsim ntawm pseudomembranous enterocolitis (muaj tsawg kawg nkaus).

Clindacin lee, cov lus qhia rau kev siv

Clindacin lee yog npaj rau kev siv intravaginal siv cov tshuaj tshwj xeeb, ib zaug thov suav nrog hauv cov khoom siv rau cov khoom lag luam tshuaj. Qhov pom zoo ib zaug tsuas noj ntau npaum li cas ntawm qab zib yog 100 mg clindamycin (ntim ntawm cov neeg thov kev pab cuam puv nkaus). Kev qhia ntawm cov tshuaj zoo tshaj plaws ua nyob rau yav tsaus ntuj (ua ntej yuav mus pw). Lub sijhawm tiv thaiv ntawm kev kho mob, raws li txoj cai, siv sijhawm 3 mus rau 7 hnub.

Siv cov neeg thov

Txog kev noj tshuaj kom zoo thiab kev tswj hwm cov tshuaj nplaum rau hauv chaw mos, nws raug nquahu kom siv cov neeg siv khoom pov tseg uas muaj nyob hauv pob nrog cov tshuaj thiab ua raws li cov txheej txheem ntawm lawv siv, uas yog:

tshem lub hau tiv thaiv los ntawm lub raj ntawm cov tshuaj nplaum,
ntsia hlau rau hauv qhov chaw siv cov ntawv pov tseg yas pov tseg,
nyem qhov rov qab qhov kawg ntawm lub raj txhaws kom sau tus neeg thov kev pabcuam (tus thov kev pabcuam yog suav tias yog ua tiav thaum nws tus kheej lub zog mus txog theem nres),
dag rau koj sab nraub qaum, ntxig tus neeg thov tshuaj rau hauv lub qhov paum kom tob li sai tau,
maj mam thawb tus neeg thov nkag rau hauv lub piston kom txog thaum nws tsis ua tiav,
ua tib zoo tshem tus neeg thov siv ntawm lub paum thiab muab pov tseg.

Cov tswm ciab clindacin, cov lus qhia rau kev siv

Clindacin suppositories kuj tseem siv intravaginally, nrog rau kev tswj hwm ib hnub ib ntawm 1 lub hnub, xav kom zoo dua yav tsaus ntuj (ua ntej yuav mus pw). Lub sijhawm tiv thaiv ntawm kev kho mob, raws li txoj cai, siv sijhawm 3 mus rau 7 hnub.

Txhawm rau siv cov tshuaj kom raug, ib qho kev pab txhawb nqa yuav tsum tau tso tawm ntawm tus neeg ntim khoom ntim sab nraud los ntawm kev txiav cov zaj yeeb yaj kiab tiv thaiv raws qhov kis ntawm lub tswm ciab. Tom qab ntawd, nyob rau hauv txoj haujlwm supine, nkag mus rau qhov kev pab txhawb nqa mus rau qhov chaw mos kom tob li sai tau.

Kev sib txuam

Thaum muab sib xyaw nrog clindamycin, cov hauj lwm zoo ntawm aminoglycosides yog nce ntxiv (Streptomycin), Rifampicin thiab Gentamicin.

Clindamycin yog tsis sib xws nrog Aminophylline, Erythromycin, Magnesium sulfate, Ampicillin, Calcium gluconatederivatives diphenylhydantoin thiab barbiturates.

Qhov cuam tshuam ntawm clindamycin ua rau kom cov leeg ua si ntau dua vim tias raug n-anticholinergics.

Txoj kev ntawm daim ntawv thov

Cov tswm ciab Clindacin thov: intravaginally. Ua ntej siv, ib qho suppository tso tawm los ntawm phau ntawv ntim khoom noj, tom qab txiav zaj duab xis raws li qhov txuas ntawm qhov ntsuas, nws tau qhia, yog tias ua tau, tob tob rau hauv qhov chaw mos, hauv txoj hauj lwm supine.
1 cov tshuaj tiv thaiv 1 lub sijhawm nyob rau ib hnub, tam sim ntawd ua ntej yuav mus pw rau 3-7 hnub uake.

Daim ntawv tso tawm thiab cov qauv ntawm cov tshuaj

Clindacin yog muaj nyob rau hauv daim ntawv ntawm cov tshuaj tiv thaiv kev mob rau qhov chaw mos ua haujlwm hauv cov hlwv hlwv ntawm 3 daim hauv daim duab los qhia. Cov tshuaj yog nrog cov lus qhia ntxaws ntxaws.

Lub ntsiab ua hauj lwm tseem ceeb ntawm cov tshuaj yog clindamycin phosphate, txhua qhov suppository muaj 100 mg ntawm cov tshuaj no. Cov qauv ntawm cov tswm ciab kuj suav nrog ib co lej ntawm cov khoom siv pabcuam.

Cov chaw muag tshuaj

Clindacin belongs rau cov tshuaj tua kab mob los ntawm pawg lincosamides. Cov tshuaj uas nquag ua los ntawm cov tshuaj pom tau hais tias muaj qhov dej siab ua kom tus mob ntsig txog ntau hom pathogens ntawm kev kis tus kab mob. Qhov kev txiav txim ntawm cov tshuaj yog bacteriostatic, uas yog, clindamycin phosphate, uas yog ib feem ntawm cov tshuaj tiv thaiv, inhibits qhov kev loj hlob thiab rov ua haujlwm ntawm cov hlwb ntawm cov kab mob pathological los ntawm thaiv cov synthesis ntawm cov protein ntawm microbial cell.

Cov tshuaj muaj tshuaj tiv thaiv zoo rau staphylococci, streptococci, corynebacteria, mycoplasmas, peptococci, clostridia. Ua ntej sau tshuaj rau cov tshuaj tiv thaiv kev tiv thaiv, ib tug poj niam yuav tsum tau yauv cov kab mob bacteriological thiab bacterioscopic ua rau kev zais cia kom txiav txim siab qhov rhiab ntawm cov kab mob rau ib qho tshuaj tua kab mob.

Cov tshuaj siv rau hauv kev kho mob gynecological rau kev kho mob ntawm tus kab mob vaginosis los ntawm microorganisms rhiab rau clindamycin.

Cov Yuav Tsum Tau Ua

Ua ntej pib kho nrog tshuaj, tus neeg mob yuav tsum mus ntsib tus kws kho mob poj niam, kuaj thiab ua tib zoo nyeem cov lus qhia nyob hauv ntawv. Cov tshuaj tiv thaiv yog contraindicated nyob rau hauv cov neeg mob uas lub siab tsis haum rau clindamycin lossis cov koom haum pabcuam uas tsim cov tshuaj, cov poj niam cev xeeb tub thiab cov neeg muaj malignant neoplasms ntawm phab ntsa paum.

Siv thaum cev xeeb tub thiab lactation

Hauv thawj peb lub hlis ntawm cev xeeb tub, clindacin suppositories tsis yog kws kho rau kev kho mob rau cov niam cev xeeb tub. Qhov no yog vim cov ntaub ntawv tsis txaus ntseeg txog kev nyab xeeb ntawm clindamitacin ntawm kev loj hlob ntawm tus menyuam, ntxiv rau, thawj 12 lub lis piam, txhua yam kabmob thiab cov kab ke ntawm cov menyuam tsis tau tsim, thiab cov nyhuv ntawm cov tshuaj tuaj yeem cuam tshuam loj rau cov txheej txheem no.

Hauv kev cuam tshuam thib ob thiab thib peb ntawm kev xeeb tub, kev siv cov tshuaj tiv thaiv kab mob tsuas yog ua tau raws li kev ntsuas nruj raws li kev saib xyuas ntawm tus kws kho mob thaum muaj xwm txheej muaj txiaj ntsig rau tus niam yuav tsum muaj ntau dua qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Sab sij huam

Feem ntau, cov tshuaj tau txais txiaj ntsig zoo los ntawm cov neeg mob, txawm li cas los xij, nyob rau hauv cov neeg uas muaj kev tiv thaiv ib tug neeg zuj zus mus rau clindamitacin, cov kev tsis zoo tshwm sim hauv qab no tuaj yeem tsim:

Nyob rau ib feem ntawm cov khoom hauv nruab nrog cev ntawm kev ua me nyuam - kev loj hlob ntawm cov txheej txheem mob ntawm ncauj tsev menyuam, vaginitis, colpitis,
Los ntawm cov kabmob hemopoietic - txo cov leukocytes, neutropenia, eosinophilia, thrombocytopenia, agranulocytosis,
Cov tshuaj tiv thaiv hauv zos - hlawv, khaus khaus ntawm qhov chaw mos, mob thiab tsis xis nyob,
Kev nqus dej ntawm cov tshuaj muaj tsawg, tab sis nyob rau qee qhov tsis tshua muaj neeg tuaj yeem ua rau kev txhim kho pseudomembranous enterocolitis.

Cov lus qhia tshwj xeeb

Thaum kho nrog lub paum ntawm qhov paum, nws raug nquahu kom tsis txhob sib deev.

Txij li thaum lub sijhawm kho mob nrog cov tshuaj ntawm tus poj niam, qhov chaw mos tawm yuav ua kom muaj zog, cov ntaub qhwv huv yuav tsum hnav rau kev nplij siab thiab kev nyiam huv.

Thaum coj khaub ncaws, kev kho tshuaj tsis yog nqa tawm. Koj yuav tsum tos kom txog rau thaum xaus ntawm hnub tseem ceeb thiab tsuas yog tom qab pib kev kho mob.

Thaum cev xeeb tub thiab lactation

Raws li cov lus qhia ntawm nom tswv, kev tshawb fawb soj ntsuam kev nyab xeeb ntawm clindacin thaum cev xeeb tub hauv thawj peb hlis tsis tau nqa tawm, hauv kev sib txuas nrog uas, nws siv nyob rau hauv lub sijhawm no tsis pom zoo. Clindacin kev kho mob rau cov poj niam thaum lub sijhawm II thiab III sijhawm ntawm cev xeeb tub tso cai tsuas yog thaum muaj teeb meem loj dhau ntawm cov txiaj ntsig ntawm cov kev kho mob ntawd rau leej niam, hauv qhov sib piv nrog qhov tshwm sim tsis zoo rau tus me nyuam hauv plab.

Dua li ntawm qhov no, hauv kev kho mob poj niam txiv neej muaj kev coj ua haujlwm ntawm kev teem caij clindacin nyob rau hauv II thiab III sijhawm ntawm cev xeeb tubtxij li ib co mob vaumyeej xav tau cov kev kho mob no. Xav txog kev tshuaj xyuas txog cov tshuaj no hauv kev tsim cov tshuaj nplaum, nrog rau kev tshuaj xyuas cov tshuaj tiv thaiv thaum lub sijhawm cev xeeb tub thaum lub sijhawm no, nws tsim nyog teev tias feem ntau ntawm cov mob, kev kho nrog Clindacin ua rau muaj kev tshem tawm tus kabmob sib kis tsis muaj kev cuam tshuam rau tus niam thiab tus menyuam hauv plab.

Kev rho tawm Ntawm Intravaginally Siv clindamycin nrog mis ntawm niam qhuav txiv qhuav tsis tau kawm, muaj feem nrog rau qhov twg, nws lub hom phiaj nyob hauv lub sijhawm kev pub mis ua tau tsuas yog nrog qhov zoo sib piv ntawm cov txiaj ntsig ntawm kev kho mob rau tus niam hauv kev sib piv nrog cov kev pheej hmoo uas yuav muaj rau tus menyuam mos.

Kev txheeb xyuas txog Klindatsin

Yuav luag txhua tus poj niam uas siv cov tshuaj no los kho cov kab mob vaginosis, Kuv tawm hauv kev tshuaj xyuas zoo txog cov khoom siv tiv thaiv kab mob clindacin, suav nrog cov neeg mob tau yuam kom siv cov tshuaj no nrog cev xeeb tub hauv II thiab III peb lub hlisCov. Kev txheeb xyuas txog Klindacin lee tsis yog ntau heev, tab sis lawv kuj tseem hais txog qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj kho no. Saib lub ntsiab lus dav dav rau cov neeg mob txog kev kho Klindacin cov kab mob vaginosis, nws muaj kev nyab xeeb kom pom zoo nws siv raws li kev qhia, tab sis tsuas yog tom qab sab laj tus kws tshaj lij.

Klindatsin tus nqi yuav nyob qhov twg

Piv nrog nws cov tshuaj rau kev siv tshuaj pleev (suav nrog tshuaj pleev ua kua, ua pob, muaj tshuaj, muaj tshuaj, thiab lwm yam), tus nqi ntawm clindacin yog nyob rau qib siab. Piv txwv, tus nqi Klindatsina hauv tswm ciab No. 3 yog kwv yees li 650 rubles (feem, 6 tswm ciab tuaj yeem muas tau hauv nruab nrab rau 1300 rubles). Nqi clindacin qab zib txawv ntawm 350-400 rubles rau ib lub raj ntawm 20 grams.

Kev phiv tshuaj

Genitourinary system: mob paum, qhov chaw mos candidiasis, coj khaub tsis xwm, cev tawm ntawm qhov paum, mob plab, pyelonephritis, mob chaw mos / chaw mos.

Lub cev raws li tag nrho: cov kab mob fungal, mob plab, mob taub hau, mob hauv zos, mob plab, kub ib ce, mob ntawm sab, mob thoob plaws lub cev, mob hauv zos, mob pob txha, candidiasis.

Digestive huam: xeev siab, ntuav, raws plab.

Cov tawv nqaij thiab cov qog ua kua: khaus (tsis yog nyob ntawm thaj chaw txhaj tshuaj), tawm pob, mob ntawm thaj chaw txhaj tshuaj, khaus (ntawm qhov chaw txhaj tshuaj).

Siv thaum cev xeeb tub lossis lactation

Intravaginal siv clindamycin phosphate suppositories nyob rau hauv cov poj niam cev xeeb tub hauv lub hlis thib ob ntawm cev xeeb tub, nrog rau kev siv cov kab mob clindamycin hauv kev txiav thib ob thiab thib peb tsis ua rau muaj kev cuam tshuam pathological.

Hauv cov poj niam hauv thawj peb hlis cev xeeb tub, cov tshuaj no yuav tsum siv yog tias muaj qhov qhia tsis tau.

Nws tsis paub meej tias clindamycin raug nthuav tawm hauv niam cov kua mis tom qab kev siv tshuaj clindamycin phosphate, yog li ntawd, thaum lub sijhawm pub niam mis, cov tshuaj yuav tau tawm tsuas yog thaum qhov kev cia siab pab rau leej niam tshaj qhov muaj feem yuav ua rau tus menyuam muaj mob.

Cov menyuam yaus tsis siv cov tshuaj no.

Daim ntawv thov nta

Kev siv cov paum ntawm qhov paum nrog clindamycin tuaj yeem ua rau kev loj hlob ntawm cov kab mob tsis haum, suav nrog cov poov xab.

Kev siv ncauj ntawm tes thiab niam txiv siv cov clindamycin tuaj yeem ua rau mob plab zom mov, thiab qee qhov - mob plab. Yog tias, thaum siv cov ntaub ntawv ntau npaum ntawm clindamycin rau kev tswj hwm intravaginal, kev mob plab zawv lossis lub sijhawm ntev, tom qab ntawd cov tshuaj no yuav tsum tau tshem tawm, cov txheej txheem kuaj mob tsim nyog yuav tsum tau ua thiab kev kho mob yuav tsum yog tsim nyog.

Cov neeg mob yuav tsum tau ceeb toom tias thaum kho cov khoom noj ntawm qhov chaw mos uas muaj cov clindamycin, ib qho yuav tsum tsis txhob nkag rau hauv qhov chaw mos, thiab kuj tsis txhob siv lwm yam khoom lag luam npaj rau kev tswj hwm (xws li tampons, douches).

Cov khoom ntim muaj cov khoom sib txuas uas tuaj yeem txo lub zog ntawm cov khoom siv roj hmab lossis cov khoom siv roj hmab, xws li cov hnab looj qau lossis cov chaw mos ua kom zoo nkauj. Yog li, kev siv cov khoom zoo li no thaum kho nrog tshuaj nyob rau hauv kev siv tshuaj tiv thaiv poj niam qhov quav tsis pom zoo.

Yuav luag 30% (6.5 - 70%) ntawm clindamycin yog nqus mus rau hauv cov kab ke hauv qab nruab nrog tom qab siv tshuaj tiv thaiv kev paum ntawm qhov paum.