Amoxicillin tshuaj tua kab mob rau menyuam yaus

Cov tshuaj tau noj ntawm qhov ncauj. Cov neeg laus thiab menyuam yaus hnub nyoog tshaj 10 xyoo (hnyav dua 40 kg) tau sau ntawv 0.5 g (2 tsiav tshuaj) 3 zaug hauv ib hnub, hauv kev kis mob hnyav, qhov koob tshuaj tau nce ntxiv rau 1.0 g (4 tsiav tshuaj) 3 zaug ib hnub. Qhov tshuaj ntau tshaj txhua hnub yog 6 g (24 tsiav tshuaj).

Rau kev kho mob ntawm tus mob otitis media, 0.5 g (2 tsiav tshuaj) yog tshuaj 3 zaug ib hnub.

Cov menyuam yaus hnub nyoog 5 txog 10 xyoo (nrog lub cev qhov hnyav ntawm 20 txog 40) raug tso cai 0.25 g (1 tshuaj ntsiav) 3 zaug hauv ib hnub.

Lub chav kawm ntawm kev kho mob yog 5-12 hnub (rau kev kis tus kab mob streptococcal - tsawg kawg 10 hnub).

Rau cov neeg mob uas muaj creatinine tshem tawm qis dua 10 ml ib feeb, qhov tshuaj ntawm cov tshuaj txo yog 15-50%, nrog anuria, qhov koob tshuaj yuav tsum tsis pub tshaj 2 g ib hnub.

Rau kev kho mob ntawm tus kab mob gonorrhea tsis yooj yim dua, 3.0 g yog tshuaj ib zaug (nyiam dua nrog ua ke nrog 1.0 g ntawm probenecid).

Txog kev tiv thaiv ntawm endocarditis, 3.0 g yog tau sau tseg rau 1 teev ua ntej phais thiab 1.5 g tom qab 6-8 teev.

Txog kev kho thiab tiv thaiv anthrax, cov neeg laus thiab menyuam yaus hnyav dua 20 kg tau sau tseg 0.5 g (2 tsiav tshuaj) txhua 8 teev rau 2 hlis.

Sab sij huam

Kev ua xua tsis haum: ua tau urticaria, tawv nqaij hyperemia, erythematous tawm pob, angioedema, rhinitis, pom, mob, tsis tshua - kub taub hau, mob caj dab, mob eosinophilia, exfoliative dermatitis, erythema multiforme exudative (suav nrog Stevens-Johnson syndrome), cov kev xav tshwm sim zoo ib yam li cov ntaub ntawv - kev poob siab anaphylactic.

Los ntawm lub plab zom mov: saj hloov, xeev siab, ntuav, stomatitis, glossitis, dysbiosis, raws plab, mob nyob rau hauv lub qhov quav, tsis tshua muaj - pseudomembranous enterocolitis.

Ntawm ib sab ntawm daim siab thiab cov hnyuv: cov kab mob hauv nruab nrab nce rau hauv hepatic transaminase, tsis tshua muaj kab mob siab thiab mob cholestatic daj ntseg.

Los ntawm lub paj hlwb tawg (nrog rau kev siv ntev hauv kev txhaj tshuaj ntau): ntxhov siab, ntxhov siab, pw tsis tsaug zog, ataxia, tsis meej pem, hloov cwj pwm, kev nyuaj siab, mob peripheral neuropathy, mob taub hau, kiv taub hau, nriaj.

Lab hloov: leukopenia, neutropenia, thrombocytopenic purpura, mob ntshav liab kis.

Lwm yam cuam tshuam: ua pa luv, tachycardia, interstitial nephritis, mob sib koom tes, candidiasis ntawm lub qhov ncauj ntawm lub qhov ncauj thiab lub paum, superinfection (tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj mob ntev los yog txo lub cev tsis kam).

Kev cuam tshuam nrog lwm yam tshuaj

Txo qhov ua tau zoo ntawm cov tshuaj estrogen-muaj qhov ncauj ntawm kev tiv thaiv, tshuaj, nyob rau hauv cov txheej txheem ntawm cov metabolism hauv uas para-aminobenzoic acid tsim, ethinyl estradiol - qhov kev pheej hmoo ntawm los ntshav "hla". Txo kev tshem tawm thiab ua rau muaj kuab lom ntawm methotrexate. Txhim kho kev nqus digoxin. Tsub kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (suppressing lub plab hnyuv microflora, txo cov synthesis ntawm vitamin K thiab prothrombin index). Kev soj ntsuam ntawm lub sijhawm prothrombin yuav tsum tau nqa nrog kev tswj hwm thooj txhij nrog anticoagulants.

Antacids, glucosamine, laxatives qeeb thiab txo qis, thiab ascorbic acid nce ntxiv kev nqus. Kev tshem tawm yog maj mam poob los ntawm probenecid, allopurinol, sulfinpyrazone, acetylsalicylic acid, indomethacin, oxyphenbutazone, phenylbutazone thiab lwm yam tshuaj uas txwv tubular zais cia.

Cov kev ua haujlwm tua kab mob tsawg dua nrog kev siv ua ke nrog cov tshuaj tua kab mob bacteriostatic cov tshuaj tua kab mob, nce nrog kev sib xyaw nrog aminoglycosides thiab metronidazole. Ua kom tiav cov ntoo khaub lig-tsis kam ntawm ampicillin thiab amoxicillin yog cai.

Daim ntawv thov nta

Kev kho yuav tsum tau txuas ntxiv rau lwm 48-72 teev tom qab ploj ntawm cov tsos mob soj ntsuam ntawm tus kab mob.

Nrog rau kev siv tshuaj sib luag nrog cov tshuaj estrogen uas muaj qhov ncauj txwv tsis pub thiab amoxicillin, yuav tsum siv lwm txoj kev tswj kom tsis txhob muaj menyuam yaus yog tias ua tau.

Hauv cov neeg mob uas lub raum tsis zoo, yuav tsum tau txhaj ib koob.

Cov yam ntxwv ntawm kev siv tshuaj yeeb hauv kev kho mob hauv cov menyuam yaus:

Contraindicated rau cov menyuam yaus hnub nyoog qis dua 6 xyoo (rau daim ntawv no ntau npaum)

Cov yam ntxwv ntawm kev siv cov tshuaj hauv kev xyaum ua geriatric:

Koob tshuaj hloov kho hauv cov neeg mob laus tsis tas yuav. Txawm li cas los xij, hauv cov neeg laus cov neeg mob, txo qis lub raum kev ua haujlwm yog qhov ntau dua, yog li ntawd ceev faj yuav tsum tau siv kev xaiv koob tshuaj thiab saib xyuas lub raum ua haujlwm vim qhov muaj feem ua rau muaj kev phom sij.

Siv thaum cev xeeb tub thiab lactationCov. Cov ntaub ntawv hais txog qhov ua tau embryotoxic, teratogenic lossis mutagenic cov teebmeem ntawm amoxicillin thaum noj thaum cev xeeb tub tam sim no tseem tsis tau muaj. Thaum cev xeeb tub, nws yog siv rau kev noj qab haus huv, ua tib zoo saib xyuas qhov ua haujlwm tshwm sim rau leej niam thiab muaj feem ua rau muaj menyuam hauv plab. Kev siv cov amoxicillin yog sib kis thaum lactation (nws yog qhov yuav tsum tau tsum tsis txhob pub mis niam thaum kho). Amoxicillin kis mus rau niam mis, uas tuaj yeem ua rau kev txhim kho ntawm cov kev xav tshwm sim hauv tus menyuam.

Kev tiv thaiv kev nyab xeeb

Hauv cov txheej txheem ntawm kev kho mob mus ntev, nws yog ib qhov tsim nyog los saib xyuas lub xeev ntawm txoj haujlwm ntawm cov ntshav hematopoietic plab hnyuv siab raum, mob siab thiab raum.

Nws muaj peev xwm los tsim superinfection vim kev loj hlob ntawm microflora tsis raug rau nws, uas yuav tsum muaj kev hloov pauv hauv kev siv tshuaj tua kab mob.

Thaum kws kho mob rau tus neeg mob sepsis, kev txhim kho ntawm cov tshuaj tiv thaiv bacteriolysis (Yarish-Herxheimer cov tshuaj tiv thaiv) yog qhov ua tau (tsis tshua muaj).

Cov neeg mob nrog tus kab mob gonorrhea yuav tsum yauv mus kuaj mob syphilis lub sijhawm kuaj mob. Hauv cov neeg mob uas tau txais amoxicillin, tom qab kev soj ntsuam serological rau mob syphilis yuav tsum tau ua tom qab 3 lub hlis.

Nrog saib xyuas siv rau hauv cov neeg mob nws nquag muaj kev fab tshuaj rau.

Muaj feem xyuam rau kev muaj peev xwm ntawm kev tsav tsheb thiab lwm yam muaj peev xwm

txaus ntshai tshuabCov. Siv cov tshuaj nrog ceev faj rau cov neeg uas tau noj amoxicillin hauv koob tshuaj ntev ntev.

Kev ntsuas rau siv

Cov tshuaj tua kab mob Amoxicillin qhia tau rau cov neeg laus thiab menyuam yaus siv. Cov ntawv tso tawm ntawm cov tshuaj sib txawv. Rau cov neeg laus, ntsiav tshuaj, tshuaj ntsiav, hmoov yog qhov tsim nyog, thiab cov tshuaj tua kab mob hauv daim ntawv ntawm cov kev daws teeb meem, kev ncua kev kawm, cov ntsiav tshuaj soluble, cov dej haus kom haum rau cov menyuam yaus mus txog ib xyoos. Tsuas noj rau txhua daim ntawv teev tshuaj yuav txawv.

Piv txwv, cov ntsiav tshuaj thiab tshuaj ntsiav tuaj yeem yog 1.0 g, 0.5 g, 0.25 g ib qho. Cov kev daws teeb meem thiab cov hmoov qhuav yog muag tau ntawm 125 mg, 375 mg, 250 mg, 400 mg, 500 mg, 1000 mg Nws yog qhov yooj yim los yug lawv tam sim ntawd ua ntej siv.

Cov tshuaj tua kab mob hauv lub pob ntim nrog cov lus qhia rau siv. Kev ncua thiab tshem cov ntsiav tshuaj yog muag nrog qhov ntsuas ntawm qhov ntsuas, uas nws yooj yim los xam cov tshuaj noj. Cov tshuaj tua kab mob no feem ntau yuav saj tsis zoo, yog li, tsim nyog rau menyuam yaus txog li ib xyoos.

Qhia tshuaj Amoxicillin yog siv yog tias tus menyuam muaj:

• Kab mob Otolaryngological
• Kev mob kis thiab mob rau lub raum, mob txeeb zig,
• Cov kab mob sib kis ntau, cov kab mob ua rau raug mob rau cov kab mob penicillin-rhiab,
• Mob plab o,
• Kev kis mob thiab o ntawm daim tawv nqaij thiab mos integument.

Ib qho tshuaj tua kab mob kuj tseem siv tau yog tias tus me nyuam tau sau tseg ua kev kho mob rau cov mob hnyav ntawm lub plab (mob plab duodenal)

Cov lus qhia rau kev siv

Cov lus qhia rau kev siv txuam nrog kev siv tshuaj rau ib hom ntawv thiab qhov ntau npaum li cas, uas nyob ntawm lub hnub nyoog ntawm tus menyuam. Piv txwv li, rau cov menyuam yaus hnub nyoog tsib xyoos, kua qab zib lossis ncua kev kawm yog qhov tsim nyog. Daim ntawv tso tawm ntawm cov tshuaj no yog tsim nyog txawm tias tau yug menyuam tshiab. Thaum siv kev ncua, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv nws lub zog. Yog tias tus me nyuam tsis ua xua nrog cov khoom qab zib, koj tuaj yeem muab kua txiv rau nws.

Dilute cov kev tshem tawm raws li kev pom zoo los ntawm cov lus qhia rau kev siv. Rau kev txhawm rau hmoov los yog granules, tsuas yog cov rhaub dej yog xav tau, txias txias rau chav sov. Ncuav me me ntawm cov dej rau hauv lub hmoov vial. Co lub thawv kom muaj zog. Nco ntsoov tias lub sijhawm rau kev daws teeb meem tsis pub dhau 14 hnub. Ib qhov chaw txias, tsaus yog qhov zoo rau khaws cia tshuaj. Tuav cov tshuaj yog tsim nyog ua ntej txhua koob.

Cov lus qhia pom zoo tias tus menyuam yaus hnub nyoog qis dua 3 xyoos muab tsis ntau tshaj 250 mg tshuaj ib hnub ob zaug. Qhov koob tshuaj txhua hnub yuav yog 500 mg. Cov menyuam yaus hnub nyoog qis dua ib xyoos yuav raug txiav txim los ntawm tus kws kho mob. Lub chav kawm ntawm kev siv tshuaj tua kab mob sib txawv ntawm tsib mus rau kaum hnub thiab nyob ntawm qhov mob hnyav ntawm tus kab mob thiab tus mob ntawm tus neeg mob.

Qee zaum koj yuav tsum xam qhov feem, uas yog 20 mg ntawm tshuaj tua kab mob rau 1 kg ntawm tib neeg qhov hnyav. Qhov kev xam no yuav nqa los ntawm kws kho mob yog tias tus menyuam mos. Yog li, piv txwv li, ib koob tshuaj 250 yog tsim rau tus menyuam yaus hnyav txog 10 kg. Ib tug menyuam yaus txog ib xyoos, piv txwv li, thaum muaj hnub nyoog 9 hlis, hnyav txog 20 kg, yuav siv tshuaj Amoxicillin, noj ntau npaum li 400-500 mg. Cov. Ntau zaus, cov menyuam tau raug txhaj tshuaj tsawg dua, piv txwv li 125 mg. Nws yog ib qho tsim nyog los yug cov tshuaj noj mus rau hauv tus account qhov muab tshuaj ntau npaum li cas!

• Rau cov menyuam muaj hnub nyoog dhau tsib xyoos, kev txhaj tshuaj ntawm 500 mg raug tso cai. Nws yuav tsum tau muab faib ua tag nrho cov hnub thiab muab ob zaug ib hnub, 250 mg thaum sawv ntxov thiab yav tsaus ntuj.
• Cov menyuam yaus hnub nyoog ntau dua kaum xyoo thiab cov laus siv tau los ntawm 500 mus rau 2000 mg ntawm cov tshuaj ib hnub. Qhov koob tshuaj yog nyob ntawm qhov mob hnyav, tus mob ntawm tus neeg mob, qee zaum cov kws kho mob txo qhov koob rau 125 mg.

Cov lus qhia rau kev siv tsis txwv tsis pub siv cov tshuaj los ntawm cov niam thiab cov poj niam cev xeeb tub. Txawm li cas los xij, ceeb toom ntawm qhov ua tau yam tsis xav tau. Cov koob tshuaj ntawm cov tshuaj yuav tsum yog txiav txim siab nrawm los ntawm kws kho mob. Cov tshuaj yuav muag hauv cov khw muag tshuaj tsuas yog thaum tau qhia txog cov tshuaj noj.

Cov Yuav Tsum Tau Ua

Cov tshuaj tua kab mob Amoxicillin yog tus neeg nyiam siv tshaj los tiv thaiv kev ua ntawm ntau tus kab mob. Cov tshuaj nquag cuam tshuam rau aerobic thiab gram-zoo cov kab mob. Tab sis tsis tas cov tshuaj no tuaj yeem noj raws li cov lus qhia. Muaj cov kab pathologies lossis cov kabmob uas qhov sib txawv ntawm cov tshuaj lossis cov tshuaj tiv thaiv kab mob txhua lub sijhawm, nws zoo dua kom thim. Cov lus qhia rau kev siv qhia qhov muaj ntawm contraindications rau noj cov tshuaj.

Amoxiclav tsis muaj zog yog tias tus menyuam:

Amoxicillin tsis haum rau siv yog tias tus me nyuam:

1. Tus kab mob virus
2. Mob pathological ntawm lub siab los yog ob lub raum,
3. Kev kis tus kab mob hauv cov mob ncauj lus,
4. Tso quav zoo lossis mob raws plab.

Tsis tas li, cov ntsiav tshuaj, koob tshuaj uas yog 125, 250, 375, 400, 500 mg., Yuav tsis pab nrhiav pom tus mob khaub thuas lossis SARS, yog tias tus menyuam tsis haum rau cov tshuaj tua kab mob lossis tus menyuam tau mob diathesis lossis mob plab.

Sab sij huam

Yog tias cov tshuaj tsis raug noj raws li qhov tseeb, cov kev mob tshwm sim yuav tshwm sim. Feem ntau cov kev phiv los ntawm cov tshuaj tiv thaiv yog cov kev tsis haum tshuaj. Lawv tuaj yeem tshwm sim ua pob khaus rau ntawm daim tawv nqaij, nyob rau hauv daim ntawv ntawm rhinitis, Quincke's edema, muaj qee zaum yuav muaj kev poob siab anaphylactic. Tsawg dua qhov rov tshwm sim yog kiv taub hau thiab mob plab. Cov tib cov teebmeem tuaj yeem tshwm sim thaum kev siv lub sijhawm ntev ntawm cov tshuaj. Cov tshuaj tiv thaiv yuav tsum tsis txhob muab rau tus menyuam ntev dua li tus kws kho mob tau sau tseg.

Ntxiv nrog rau kev ua xua, tus menyuam yuav muaj teeb meem nrog cov zom zaub mov. Cov kev qhia ua ntu zus muaj xws li xeev siab thiab qhov tshwm sim ntawm ntuav rov qab los. Muaj kev ua txhaum ntawm saj. Zawv plab yuav tshwm sim. Tsis tas li ntawv phiv los ntawm kev siv tshuaj tsis raug cai suav nrog kev ua kom tsis tsaug zog, lub xeev muaj kev kub ntxhov, ntxhov siab, ntxhov siab, thiab mob taub hau yuav tshwm sim.

Muaj ntau ntau yam tshuaj uas nws cov tshuaj nquag yog amoxicillin. Piv txwv, cov chaw tsim khoom hauv Lavxias Norton tsim Solutab ntsiav tshuaj. Muaj ib qho tshuaj tiv thaiv Lavxias teb sab Amoxicillin trihydrate ntawm kev muag. Lub chaw tsim khoom lag luam hauv German muab cov qhua tuaj noj mov ua qauv Rathiopharm thiab Amoxillat. Muaj ib qhov piv txwv zoo rau Sumamed. Sumamed yog nyob rau hauv tsiav tshuaj, hmoov los yog ua raw khoom rau kev ncua, hauv daim ntawv ntawm hmoov ntau. Qhov kev ncua tsis taus yog qhov zoo rau menyuam yaus. Lub txim raug tshem tawm yog muaj tiav nrog cov ntsuas qhov ntsuas lossis cov koob txhaj tshuaj.

Lub tuam txhab Israeli chaw muag tshuaj muaj cov qauv analogues hu ua Teva. Cov tshuaj tua kab mob Austrian yog tsim los ntawm lub tuam txhab Sandoz. Lub Canadian counterpart yog muaj nyob rau hauv lub npe Apo-Amoxi. Muaj kev npaj ntawm Fabkis Butox, Austrian Gonoform, Ospamox, German Grunamox, Indian Danemox, Egyptian Emox. Ntawm kev muag koj tuaj yeem nrhiav cov analogues ua nyob rau hauv Bangladesh, Slovenia thiab lwm tus. Tus nqi ntawm analogues yog txawv.

Ib qho ntawm feem pheej pheej yig analogues yog Lavxias tshuaj Amosin. Ib qho ntawm cov tshuaj tiv thaiv zoo uas feem ntau yuav rau cov menyuam yaus yog Flemosin. Lub qab ntxiag saj tshuaj tua kab mob tuaj yeem zom, yaj hauv dej lossis tshuaj yej, tsuas yog nqos tau.

Amoxicillin kua ncua kev kawm txauv yog kim dua. Ntau kim dua yog cov tshuaj Amoxicillin, uas muaj clavuanic acid. Qhov no yog hu ua Amoxicillin Amoxiclav - qhov no yog ib qho tshuaj ntau dua. Nws yog tshuaj rau tib hom kabmob uas amoxicillin kho tau. Cov menyuam yaus yuav tsum siv tshuaj amoxiclav nrog kev ceev faj yog tias muaj kev ua txhaum ntawm kev ua haujlwm ntawm lub raum, mob siab, mob hnyuv. Amoxiclav muaj feem cuam tshuam txog kev ua haujlwm ntawm kev tiv thaiv, uas tau coj hauv cov tshuaj ntsiav tshuaj. Amoxiclav yog siv tsis tau nrog cov tshuaj tua kab mob aminoglycoside. Lwm qhov txuas rau nrov yog Augmentin. Cov tshuaj muaj pes tsawg leeg kuj suav nrog amoxicillin thiab clavulanic acid. Augmentin feem ntau yog tshuaj rau cov menyuam yaus, nws muaj nyob hauv cov npe ntawm cov tshuaj tseem ceeb.

Tus nqi ntawm analogues ntawm amoxicillin pab pawg ntawm cov tshuaj tua kab mob nyob ntawm tus tsim khoom ntawm cov tshuaj thiab ntau npaum. Amoxicillin yog muag hauv qhov tshuaj ntau npaum li 250, 500, 1000 mg. Tus nqi ntawm cov tshuaj yog los ntawm 36 mus rau 320 rubles. Cov lus piav qhia nyob hauv cov npe lag luam Forte raug muag hauv tshuaj ntsiav, hauv qhov tau 500 mg, ntawm tus nqi los ntawm 250 rubles.

Lavxias Amoxicillin Amofast yog tsim rau cov menyuam yaus, vim nws muaj qhov qab ntxiag apricot. Cov tshuaj raug muag hauv cov ntsiav tshuaj hauv qhov ntau npaum ntawm 375 mg txog 750 mg. Tus nqi ntawm cov tshuaj yog los ntawm 75 rubles.

Cov tshuaj Gramox yog tib yam Amoxicillin hauv tshuaj ntawm 500 mg, nws tus nqi yog los ntawm 90 rubles. Ospamox yog muag nyob rau hauv daim ntawv ntawm tsiav tshuaj nyob rau hauv ib qhov tshuaj ntawm 250 mg, nws tus nqi yog kwv yees li 300 rubles. Pressmox muaj muag nyob rau hauv cov ntsiav tshuaj hauv qhov ntau npaum ntawm 125 mg. Cov ntsiav tshuaj tuaj yeem muaj lub txiv kab ntxwv lossis txiv kab ntxwv tsw, zoo rau me nyuam yaus. Tus nqi nruab nrab ntawm cov tshuaj yog los ntawm 120 rubles.

Dosage daim ntawv

250 mg ntsiav tshuaj

Ib ntsiav tshuaj muaj

cov tshuaj heev - amoxicillin trihydrate 287 mg

(sib npaug rau 250 mg amoxicillin)

tus zam: qos yaj ywm hmoov txhuv nplej siab, calcium los yog magnesium stearate, lactose monohydrate

Cov ntsiav tshuaj dawb lossis dawb nrog lub ntsej muag daj, puag ncig, nrog lub ntsej muag me ntsis hauv qab, ntawm ib sab ntawm kev pheej hmoo

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, nws nrawm thiab yuav luag tiav (txog 93%) nqus tau, tsim kom muaj qhov siab tshaj plaws (1.5–3 μg / ml thiab 3.5–5 μg / ml, feem) tom qab 1-2 teev. tsis cuam tshuam rau nqus. Kev khi rau cov ntshav plasma protein yog li 17%. Nws yooj yim hla keeb kwm kev tiv thaiv, tshwj tsis yog cov ntshav tsis haum rau lub hlwb, thiab nkag mus rau feem ntau cov ntaub so ntswg thiab kabmob, nthuav tawm hauv kev kho mob ntau ntau hauv cov kua dej peritoneal, tso zis, muaj cov tawv nqaij ua paug, pleural effusion, lub ntsws (tab sis tsis yog nyob rau hauv purulent bronchial secretion), plab hnyuv tawm, poj niam cov qau, nruab nrab lub ntsej muag, lub plab zais thiab cov kua tsib (nrog lub siab ua haujlwm), cov nqaij hauv plab. Ib nrab-lub neej yog 1-1.5 teev .Thaum muaj qhov tsis taus lub raum lub hlwb, ib nrab-lub neej tau txuas ntxiv rau 4-12,6 teev, nyob ntawm tus neeg tsim khoom muaj meej.Ib nrab metabolized los ua cov roj metabolites tsis muaj zog. 50-70% yog tawm los ntawm lub raum tsis hloov pauv los ntawm canalcium excretion (80%) thiab glomerular pom (20%), 10-20% los ntawm lub siab. Ib qho me me yog tawm hauv niam cov kua mis. Qhov kev txiav txim tsim 15-30 feeb tom qab kev tswj hwm thiab kav ntev li 8 teev.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog ib qho tshuaj tua kab mob ntau yam los ntawm pab pawg ntawm semisynthetic penicillins, nws yog bactericidal. Nws inhibits transpeptidase, cuam tshuam kev tsim ntawm peptidoglycan thaum lub sij hawm faib thiab kev loj hlob, thiab ua rau lysis ntawm cov kab mob me me. Nquag nquag tawm tsam gram-zoo cocci - Dab Tsi Staphylococcus spp. (tsis suav nrog rau penicillinase ua cov leeg), Streptococcus spp. Nws kuj tseem nquag tawm tsam gram-negative aerobic microorganisms: Neisseriagonorrhoeae,Neisseriamob meningitidis,Esherichiacoli,Ntxaug Yajspp.,Salmonellaspp.,Klebsiellaspp.

Amoxicillin tsis muaj kev kho rau hauv txhua hom tsiaj uas tsis tseem ceeb. Proteus,Klebsiellaspp.,Enterobacterspp.,Serratiaspp.,Pseudomonasspp.,Stenotrophomonasmaltophilia,Citrobacterspp. thiab penicillinase ua cov kab mob.

Amoxicillin tsis tiv taus penicillinase.

Muaj qhov ua tiav hla-ua hauj nrog ampicillin.

Sab sij huam

- tawv nqaij hyperemia, tawv nqaij ua pob khaus, khaus, urticaria, erythema multiforme, Stevens-Johnson syndrome, lom cov tawv nqaij ua kom haum, Quincke's edema.

- ua npaws, ua tsis taus pa, rhinitis, mob pob txha

- mob sib koom tes

- saj hloov, ntuav, xeev siab, raws plab, stomatitis, glossitis, dysbiosis, pseudomembranous enterocolitis

- Lub siab ua haujlwm tsis zoo, nce ntxiv "qog" transaminases, kab mob siab thiab mob cholestatic daj ntseg

- mob taub hau, kiv taub hau, ntxhov siab, ntxhov siab, pw tsis tsaug zog,

ataxia, tsis meej pem, hloov cwj pwm, kev hloov pauv, peripheral neuropathy, mob tshwm sim

- thim rov qab cov leukopenia, suav nrog neutropenia thiab agranulocytosis, eosinophilia

- thim rov qab thrombocytopenia, thrombocytopenic purpura, ntshav tsis txaus

- lub caij nyoog ntawm los ntshav lub sijhawm thiab lub sijhawm prothrombin

- kev ua haujlwm tawv thiab ua kom tawv nqaij dermatitis, angioedema, anaphylactic kev hloov pauv, mob ntshav tawm, mob vasculitis, tshuaj tiv thaiv anaphylactic

Cov tshuaj sib cuam tshuam

Probenecid, Allopurinol, oxyphenbutazone, phenylbutazone, NSAIDs, thiab lwm yam. Nrog rau kev siv tib txhij nrog allopurinol, ib qho kev nce ntawm cov zaus ntawm kev fab tshuaj los ntawm daim tawv nqaij yog ua tau.

Diuretics ua kom nrawm rau tso tawm ntawm amoxicillin, uas ua rau txo qis hauv kev mloog zoo ntawm cov tshuaj nquag hauv cov ntshav.

Amoxicillin txo cov txiaj ntsig ntawm cov tshuaj estrogen-hauv qhov ncauj ua kom muaj kev tiv thaiv thiab muaj lub peev xwm los ntshav nrog kev siv tib lub sijhawm. Lwm qhov kev tiv thaiv tsis muaj tshuaj hormones yog pom zoo.

Amoxicillin txo qis kev ua kom huv thiab ua kom muaj kuab lom ntawm methotrexate, txhim kho kev nqus ntawm digoxin.

Cov tshuaj tsis sib haum nrog aminoglycosides.

Cov kab mob tua kab mob (cephalosporin, vancomycin, rifampicin, metranidozole) muaj cov nyhuv synergistic.

Cov tshuaj uas muaj cov bacteriostatic nyhuv (tetracyclines, erythromycin, macrolides, chloramphenicol, lincosamides, sulfonamides) muaj qhov ua haujlwm antagonistic thiab tuaj yeem ua rau cov kab mob bactericidal ntawm amoxicillin.

Antacids, glucosamine, laxatives, zaub mov, aminoglycosides qeeb thiab txo qhov nqus ntawm amoxicillin.

Ascorbic acid nce ntxiv ntawm kev nqus ntawm amoxicillin.

Nrog rau kev siv ib txhij nrog anticoagulants, tswj hwm lub sijhawm prothrombin yog qhov tsim nyog, txij li qhov muaj peev xwm los ntshav nce ntxiv.

Qhov nqus ntawm amoxicillin yog txo thaum nws noj hauv ob teev tom qab noj cov tshuaj tiv thaiv, xws li kaolin. Yog li, nws raug nquahu kom soj ntsuam ib ncua sijhawm tsawg kawg 2 teev ntawm kev noj cov tshuaj no.

Cov lus qhia tshwj xeeb

Nrog saib xyuas siv rau hauv cov neeg mob nws nquag muaj kev fab tshuaj rau.

Nrog saib xyuas yuav tsum tau tsim tshuaj rau lub raum tsis ua haujlwm, keeb kwm ntawm los ntshav.

Nrog chav kawm ntawm txoj kev kho mob, nws yog ib qhov tsim nyog los saib xyuas lub xeev ntawm txoj haujlwm ntawm cov ntshav, daim siab thiab lub raum.

Tej zaum qhov kev txhim kho superinfection vim kev loj hlob ntawm microflora tsis raug rau nws, uas yuav tsum tau kho kom zoo ntawm cov tshuaj tua kab mob.

Hauv kev kho mob rau cov neeg mob bacteremia, kev txhim kho ntawm cov tshuaj tiv thaiv bacteriolysis (Jarisch-Herxheimer cov tshuaj tiv thaiv) tau muaj.

Hauv cov neeg mob uas muaj lub siab ntsws ua rau penicillins, hla kev tsis haum nrog tshuaj tua kab mob cephalosporin yog ua tau.

Hauv kev kho mob raws plab mob nrog kev kho mob, kev siv tshuaj tiv thaiv kab mob uas ua kom txo plab hnyuv yuav tsum zam. Tsis txhob siv rau cov kab mob ntawm lub plab zom mov nrog lub plab ua kom mob ntev los yog ntuav, nrog rau kab mob siab.

Siv nrog metronidazole, nws tsis pom zoo rau siv rau hauv cov neeg mob hnub nyoog qis dua 18 xyoo.

Daim ntawv thov cov yam ntxwv thaum tsav tsheb thiab lwm yam khoom muaj feem phom sij

Xav txog qhov ua tau los ntawm kev phiv, ceev faj yuav tsum tau siv thaum tsav tsheb thiab lwm yam uas yuav muaj kev phom sij.

Cov lus sib xyaw thiab ntau npaum cov ntawv

Muaj 3 daim ntawv loj ntawm cov tshuaj tso tawm - cov ntsiav tshuaj, tshuaj ntsiav thiab granules. Hauv txhua qhov xwm txheej no, cov tshuaj tseem ceeb yog amoxicillin ua ib hom trihydrate. Tib lub sijhawm, cov tshuaj ntsiav tau tsim nyob hauv qhov sib txawv - 250 mg thiab 500 mg.

Muaj 3 daim ntawv tseem ceeb ntawm Amoxicillin tso tawm - ntsiav tshuaj, tshuaj ntsiav thiab granules.

Granules yog npaj rau kev ncua. Txawm hais tias kev txhaj tshuaj hauv ampoules tsis yog muab los ntawm cov chaw tsim khoom, Invesa tsim cov tshuaj txhaj rau hauv 10 ml vials.

Pharmacological kev txiav txim

Amoxicillin yog ib hom tshuaj uas muaj thoob plaws. Nws lub ntsiab kom zoo dua yog kev ua haujlwm siab thiab ceev nrawm.

Amoxicillin muaj cov nyhuv bactericidal tawm tsam:

• gram-zoo cocci, uas suav nrog streptococci, pneumococci, enterococci, staphylococci rhiab rau penicillin,
• qws-zoo lawm (corynebacteria thiab listeria),
• gram-negative cocci, uas suav nrog neysseries,
• gram-negative sticks (Helicobacter pylori, ua rau lub plab zom mov, thiab ua rau cov leeg ntshav tsis huv, qee hom mob enterobacteria).

Amoxicillin yog siv tawm tsam Escherichia coli, tus kab mob anaerobic, actinomycetes thiab spirochetes, ua rau mob borreliosis. Rau qee cov microbes, cov tshuaj muaj cov nyhuv bacteriostatic.

Cov tshuaj yog nquag tiv thaiv cov kab mob sib kis ntawm feem ntau ntawm cov kab mob ua pa. Thiab txawm hais tias cov tshuaj yog ib qho kev sib txuas ntawm ampicillin, nws suav tias yog qhov ua tau zoo dua vim tias nws tau txhim kho pharmacokinetics - nws pib ua haujlwm sai dua, nrog nws siv nws muaj qhov siab zoo hauv cov ntshav plasma thiab cov nqaij ntawm cov tshuaj yeeb dej caw.

Amoxicillin yog siv tawm tsam E. coli.

Amoxicillin zoo nqus tom qab kev tswj hwm qhov ncauj. Lub bioavailability ntawm cov nquag tshuaj yog 95%. Amoxicillin nkag mus rau hauv yuav luag txhua daim ntaub ntawm lub cev, suav nrog lub ntsws, daim siab, cov leeg, lub zais zis, cov kua dej synovial tag nrho (yog li ntawd, nws tuaj yeem siv rau cov mob sib kis), pleural, qaub ncaug thiab qhov zais ntawm cov hlab ntshav. Hauv cov kua dej ua haujlwm cerebrospinal, nws qhov kev kub siab tsawg, uas ua rau kev kho mob rau mob hlwb.

Amoxicillin yog tshuaj tua kab mob ib nrab hnub uas tuaj yeem nkag mus rau hauv qhov chaw tiv thaiv thaum lub cev xeeb tub. Txawm li cas los xij, kev tshawb fawb pom tau tias qhov tshuaj lom neeg tsis nkag mus rau niam mis.

Amoxicillin yog tus cwj pwm los ntawm kev khi qis rau cov ntshav protein - tsuas yog 20%. Nws yog tawm los ntawm lub raum yuav luag tsis hloov. Qhov kev tshem tawm ib nrab-lub neej ua rau 60-90 feeb.