Lipothioxone - cov lus qhia ntawm kev siv > Kev khomob thiab kev tiv thaiv

Yam tshuaj muaj sia:
Meglumina thioctate **	- 583,86 mg,	- 1167.72 mg
nyob rau hauv cov nqe lus ntawm thioctic acid (alpha lipoic acid)	- 300 mg	- 600 mg
Cov muaj tswv yim:
Macrogol (macrogol-300)	- 2400 mg	- 4800 mg
Sodium Sulfite Anhydrous	- 6 mg	- 12 mg
Disodium edetate	- 6 mg	- 12 mg
Meglumine	12,5 mg txog 35 mg (txog rau pH 8.0-9.0),	25 mg txog 70 mg (nce txog pH 8.0-9.0)
Dej rau kev txhaj tshuaj	txog 12 ml	txog li 24 ml

** meglumine thioctate yog tsim los ntawm kev sib cuam tshuam ntawm thioctic acid 300 mg (600 mg) thiab meglumine 283.86 mg (567.72 mg)

cov kua ntshiab los ntawm lub teeb daj mus rau lub teeb daj ntsuab.

Cov chaw muag tshuaj

Thioctic acid (alpha-lipoic acid) - ib qho kev tiv thaiv tsis muaj kabmob (khi dawb radicals), yog tsim nyob rau hauv lub cev los ntawm oxidative decarboxylation ntawm alpha-keto acids. Raws li coenzyme ntawm mitochondrial multienzyme complexes, nws koom nrog oxidative decarboxylation ntawm pyruvic acid thiab alpha-keto acids. Nws pab txhawm rau txo qis kev mloog ntawm cov piam thaj hauv cov ntshav thiab nce glycogen hauv lub siab, ntxiv rau kov yeej cov tshuaj insulin. Los ntawm cov kev ua haujlwm biochemical, nws yog nyob ze rau cov vitamins B. Koom nrog cov kev cai ntawm lipid thiab carbohydrate metabolism, txhawb cov metabolism hauv roj, thiab txhim kho daim siab ua haujlwm. Nws muaj cov kab mob hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Txhim kho trophic neurons.

Cov Tshuaj Pharmacokinetics
Nrog kev tswj hwm lub sijhawm, lub sijhawm kom mus txog qhov siab tshaj plaws yog 10-11 min, qhov siab tshaj plaws yog 25-38 μg / ml, thaj tsam hauv qab-lub sij hawm nkhaus yog li 5 μg h / ml. Bioavailability yog 30%.
Thioctic acid muaj qhov ua tau “ua ntej dhau” lub siab los ntawm daim siab. Qhov tsim ntawm metabolites tshwm sim los ntawm sab saw oxidation thiab kev sib txuas.
Qhov ntim ntawm kev faib tawm yog li 450 ml / kg. Thioctic acid thiab nws cov metabolites yog ua kom lub raum tso tawm (80-90%). Qhov kev tshem tawm ib nrab-lub neej yog 20-50 feeb. Tag nrho cov ntshav tshem tawm yog 10-15 ml / min.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yog npaj rau kev npaj ntawm kev daws rau infusion tom qab ua ntej dilution hauv ib qho isotonic sodium chloride tov.
Hauv cov ntawv hnyav ntawm cov ntshav qab zib lossis dej cawv polyneuropathy, 300-600 mg 1 zaug hauv ib hnub yuav tsum tau muab rau cov tshuaj txau ntshav dej. Txoj kev lis ntshav ntawm lub plab yuav tsum tau muab nyob hauv 50 feeb. Cov tshuaj raug pom zoo rau kev siv hauv 2-4 lub lis piam. Tom qab ntawd, koj tuaj yeem txuas ntxiv noj thioctic acid hauv ib koob ntawm 300-600 mg ib hnub twg. Lub sijhawm tsawg kawg ntawm kev kho mob nrog cov ntsiav tshuaj yog 3 hli.

Sab sij huam

Nrog kev tswj hwm mob ntshav, ua kom mob, ua kom tiav, daim ntawv pov thawj tsis sib luag hauv cov nqaij mos, daim tawv nqaij, thrombocytopathy, hemorrhagic pob (purpura), thrombophlebitis tsis tshua muaj neeg. Nrog rau kev tswj hwm sai, kev nce hauv intracranial siab yog ua tau (qhov zoo li lub ntsej muag ntawm qhov hnyav ntawm lub taub hau), ua pa nyuaj. Cov teeb meem tshwm sim yuav ploj mus ntawm lawv tus kheej.
Kev ua xua muaj peev xwm ua tau: urticaria, mauj tshuaj tiv thaiv kev ua xua (txog kev txhim kho anaphylactic kev poob siab).
Kev mob ntshav siab ntshav qis yuav tshwm sim (vim tias kev txhim kho cov piam thaj hauv siab).

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv ntau npaum li cas yog kev mloog zoo rau qhov kev npaj ntawm ib qho kev daws teeb meem: cov kua ntshiab los ntawm greenish mus rau lub teeb daj hauv xim (hauv cardboard pob 1 contour lossis cell pob muaj 5 ampoules ntawm 12 lossis 24 ml, thiab cov lus qhia rau kev siv Lipothioxone).

Muaj pes tsawg leeg ib 1 ampoule:

cov tshuaj nquag: thioctic (lip-lipoic) acid - 300 lossis 600 mg (ua meglumine thioctate - 583.86 lossis 1167.72 mg, tsim los ntawm kev sib cuam tshuam ntawm thioctic acid thiab meglumine),
Cov khoom siv pabcuam (300/600 mg): anhydrous sodium sulfite - 6/12 mg, macrogol-300 - 2400/4800 mg, meglumine - txog pH 8–9 (12.5–35 mg / 25–70 mg), edetate disodium - 6/12 mg, dej rau kev txhaj tshuaj - txog 12/24 ml.

Cov Tshuaj Hauv Tshuaj

Thioctic (lip-lipoic) acid yog cov tshuaj tiv thaiv kab mob tsis txaus uas khi cov tshuaj dawb, qhov tsim nyob rau hauv lub cev tshwm sim thaum lub sijhawm oxidative decarboxylation ntawm α-keto acids. Raws li coenzyme ntawm mitochondrial multienzyme complexes, thioctic acid yog koom nrog oxidative decarboxylation ntawm acids-keto acids thiab pyruvic acid.

Lipothioxone muaj cov kab mob hepatoprotective, hypolipidemic, hypoglycemic thiab hypocholesterolemic effect. Los ntawm cov xwm txheej biochemical ntawm α-lipoic acid nyob ze rau cov vitamins ntawm pab pawg B.

Lub ntsiab cuam tshuam ntawm thioctic acid:

txo hauv cov ntshav qabzib concentration,
nce glycogen hauv lub siab,
overcoming insulin kuj,
kev koom tes nyob rau hauv cov kev cai ntawm kev ua kom yuag rog thiab roj lipid,
stimulation ntawm cov metabolism hauv cov cholesterol,
txhim kho lub cev kev ua haujlwm ntawm lub siab thiab txhim kho trophism ntawm neurons.

Cov Tshuaj Pharmacokinetics

Qhov siab tshaj plaws ntawm thioctic acid nrog kev tswj hwm tiav tau tiav hauv 10-11 feeb, nws yog 0.025-0.038 mg / ml. Thaj chaw hauv qab nkhaus "concentration - sijhawm"

0.005 mg h / ml. Bioavailability ntawm theem ntawm 30%.

Qhov tshuaj muaj cov nyhuv ntawm thawj zaug dhau los ntawm lub siab. Cov txheej txheem ntawm kev tsim cov khoom nruab nrog txuas nrog kev sib xyaw ua ke thiab oxidation ntawm lub saw sab.

450 ml / kg. Kev nqhis dej ntawm cov tshuaj thiab nws cov metabolites feem ntau tshwm sim los ntawm lub raum (ntawm 80 txog 90%). Qhov kev tshem tawm ib nrab-lub neej ua rau 20-50 feeb. Tag nrho cov ntshav tshem tawm yog nyob ntawm thaj tsam ntawm 10-15 ml / min.

Lipothioxone, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Lipothioxone raug tso tshuaj rau hauv daim ntawv ntawm infusions tom qab dilution hauv kev daws isotonic sodium tshuaj dawb tov.

Hauv cov mob hnyav ntawm pathology, cov tshuaj yog muab ib hnub ib zaug ntawm koob tshuaj 300-600 mg nrog rau 50 feeb.

Lub sijhawm pom zoo ntawm kev kho mob yog 2-4 lub lis piam. Thaum kawg ntawm lub sijhawm no, kev kho mob txuas ntxiv nrog kev tswj hwm ntawm thioctic acid nyob rau hauv tib lub sij hawm tsawg kawg yog 3 lub hlis.

Sab sij huam

Hauv qee qhov tsis tshua muaj tshwm sim, tawm tsam keeb kwm ntawm cov lus qhia ntawm Lipothioxone, muaj kev txhim kho kev tsis sib haum xeeb hauv daim ntawv ntawm qaug dab peg, diplopia, thrombophlebitis, pom cov ntshav tawm hauv daim tawv nqaij thiab cov xoos mucous, hemorrhagic pob (purpura), thrombocytopathy.

Yog tias txoj kev daws tau txhaj sai, kev ua pa nyuaj thiab nce ntawm intracranial siab tuaj yeem tshwm sim (ua kom zoo li lub siab ntawm hnyav dua hauv lub taub hau). Cov kev mob tshwm sim no feem ntau yuav ploj lawv tus kheej.

Urticaria, muaj kev tsis haum rau lub cev (txog ntus anaphylactic).

Kev txhim kho cov piam thaj hauv siab tuaj yeem ua rau ntshav qab zib ntshav qab zib.

Cov lus qhia tshwj xeeb

Cov neeg mob ntshav qab zib, tshwj xeeb tshaj yog thaum pib ntawm kev siv Lipothioxone, yuav tsum tau saib xyuas ntau zaus ntawm cov concentration ntawm cov piam thaj hauv cov ntshav. Qee zaum cov koob tshuaj hypoglycemic cov neeg sawv cev yuav tsum tau ua kom tsawg.

Nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm kho, vim nws txo qhov cuam tshuam los ntawm kev kho.

Ampoules los ntawm lub pob yuav tsum tau muab tshem tawm tsuas yog tam sim ntawd ua ntej siv, txij li Lipothioxone muaj lub siab hnyav. Thaum lub sij hawm Txoj kev lis ntshav, nws raug nquahu kom tiv thaiv kev daws teeb meem vial los ntawm kev sib kis los ntawm lub teeb los ntawm qhwv nws nrog aluminium ntawv ci lossis los ntawm muab tso rau hauv lub hnab tsis pom kev.

Tom qab dilution, lipothioxone yuav tsum tau siv rau 6 teev, muab tias nws tau khaws cia rau hauv qhov chaw tsaus.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Hauv / hauv (dav hlau, poob dej), hauv / m.

Hauv cov ntawv hnyav ntawm polyneuropathies - iv maj mam (50 mg / min), 600 mg lossis iv dej, hauv 0.9% NaCl daws ib zaug ib hnub (hauv cov xwm txheej loj, txog li 1200 mg yog tswj hwm) rau 2-4 lub lis piam. Hauv / hauv cov lus qhia yog muaj peev xwm nrog kev pab los ntawm perfuser (sijhawm ntawm kev coj ua - tsawg kawg 12 feeb).

Nrog rau / m txhaj tshuaj ntawm tib qhov chaw, qhov tshuaj ntawm cov tshuaj yuav tsum tsis pub tshaj 50 mg.

Tom qab, lawv hloov mus rau kev kho qhov ncauj rau 3 lub hlis.

Pharmacological kev txiav txim

Lub coenzyme ntawm mitochondrial multienzyme complex koom nrog oxidative decarboxylation ntawm pyruvic acid thiab alpha-keto acids ua lub luag haujlwm tseem ceeb hauv lub zog tshuav nyiaj ntawm lub cev. Los ntawm cov kev coj ua ntawm biochemical, thioctic (alpha-lipoic) acid zoo ib yam li cov vitamins B. Nws yog ib qho tshuaj antioxidant endogenous. Koom nrog cov kev cai ntawm lipid thiab carbohydrate metabolism, muaj lipotropic effect, cuam tshuam cov roj metabolism hauv lub cev, txhim kho daim siab ua haujlwm, muaj kev cuam tshuam hauv kev ua haujlwm thaum muaj tshuaj lom nrog ntsev hlau hnyav thiab lwm yam tshuaj lom. Cov txiaj ntsig ntawm cov metabolism carbohydrate yog qhia nyob rau hauv kev txo cov ntshav qabzib hauv siab thiab qhov nce ntawm glycogen hauv daim siab, nrog rau kev kov yeej cov tshuaj insulin kuj. Txhim kho trophic neurons.

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Lipothioxone

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.