Mildronate® (500 mg) Meldonium

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb TxhawjCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg siv khoom ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Mildronate hauv lawv qhov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov qauv ntawm Mildronate nyob rau hauv muaj cov qauv txheej txheem qauv. Siv los kho mob plawv thiab mob nkees thiab txhim kho cov metabolism hauv cov nqaij hauv cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab pub mis.

Txhawj - cov tshuaj uas kho cov metabolism hauv. Meldonium (cov tshuaj nquag ntawm Mildronate) yog cov qauv tshuaj tiv thaiv ntawm gamma-butyrobetaine, cov tshuaj uas muaj nyob hauv txhua lub cell ntawm tib neeg lub cev.

Nyob rau hauv cov xwm txheej ntawm qhov nce ntawm qhov nce, Mildronate rov qab qhov sib npaug ntawm kev xa thiab oxygen thov ntawm cov hlwb, tshem tawm cov kev sib txuam ntawm cov khoom lag luam lom hauv cov hlwb, tiv thaiv lawv los ntawm kev puas tsuaj, thiab tseem muaj cov txiaj ntsig tonic. Raws li kev siv, lub cev tau txais lub peev xwm los tiv thaiv lub nra thiab ceev ceev lub zog txuag. Vim tias cov khoom no, Mildronate raug siv los kho ntau yam mob tsis zoo ntawm cov hlab plawv cov ntshav, tso ntshav rau lub hlwb, ntxiv rau cov kev ua haujlwm ntawm lub cev thiab lub hlwb.

Raws li qhov txo qis hauv carnitine concentration, gamma-butyrobetaine nrog vasodilating cov khoom yog qhov sib zog ua ke. Hauv kev mob ischemic myocardial kev puas tsuaj, Mildronate qeeb qhov tsim ntawm thaj chaw necrotic, ua kom lub sijhawm rov ua kom sai.

Hauv lub plawv tsis ua hauj lwm, cov tshuaj tsub kom myocardial contractility ntau zog, ua kom ib ce muaj zog thev taus, thiab txo qhov zaus ntawm kev mob taub hau.

Hauv kev mob siab thiab mob ntsws ischemic mob hlwb cerebral ncig txhim kho cov ntshav ncig hauv kev ua kom pom tseeb ntawm ischemia, pab txhawb txoj kev rov faib cov ntshav hauv kev pom zoo ntawm thaj chaw ischemic.

Zoo rau vascular thiab dystrophic pathology ntawm lub fundus.

Cov tshuaj tshem tawm cov kev ua haujlwm tsis zoo ntawm cov hlab ntsha hlwb, txhim kho lub keeb kwm yav dhau los ntawm kev haus dej cawv hauv cov neeg mob uas muaj cawv quav ntev nrog kev tshem tawm mob.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, cov tshuaj sai tawm ntawm lub plab zom mov. Nws yog cov roj hauv lub cev hauv lub cev nrog kev tsim ntawm ob lub cev tseem ceeb uas nthuav tawm los ntawm lub raum.

Cov Khoom Qhia

• hauv txoj kev kho mob ntsig txog txoj kev mob plawv (angina pectoris, myocardial infarction), mob plawv tsis ua haujlwm, tsis ua haujlwm hlab plawv,
• nyob rau hauv txoj kev kho mob ntawm cov mob hlwb thiab mob tas mus li (cov mob nkees thiab cerebrovascular tsis txaus),
• txo qis kev ua haujlwm
• kev ntxhov siab rau lub cev (suav nrog cov kis las),
• ntsoos ntsoos Mob mob hlwb rau hauv cov dej cawv ntev (nrog rau kev kho rau kev haus dej cawv),
• hemophthalmus, retinal hemorrhages ntawm ntau yam etiologies,
• thrombosis ntawm hlab ntsha nruab nrab ntawm Retina thiab nws cov ceg,
• retinopathies ntawm ntau etiologies (mob ntshav qab zib, hypertonic).

Tso Tawm Cov Ntawv

Cov tshuaj ntsiav 250 mg thiab 500 mg (qee zaus hu ua ntsiav tshuaj yuam kev, tab sis daim ntawv ntawm cov ntsiav tshuaj Mildronate tsis muaj nyob)

Kev daws rau kev txhaj tshuaj rau hauv ntshav, kev txhaj tshuaj thiab tshuaj tua kab mob (txhaj tshuaj hauv ampoules).

Cov lus qhia rau kev siv thiab ntau npaum li cas

Hauv kev sib txuas nrog qhov ua tau los tsim qhov kev ntxim siab, cov tshuaj tau pom zoo kom siv thaum sawv ntxov.

Rau cov kab mob plawv yog ib feem ntawm txoj kev kho mob nyuaj, cov tshuaj tau tawm ntawm lub qhov ncauj ntawm 0.5-1 g ib hnub, qhov ntau zaus ntawm kev siv yog 1-2 chav kawm ntawm kev kho mob yog 4-6 lub lis piam.

Nrog cardialgia tiv thaiv ib qho keeb kwm ntawm qhov ua tsis taus pa myocardial dystrophy, Mildronate yog qhov ncauj tawm 250 mg 2 zaug hauv ib hnub. Lub chav kawm ntawm kev kho mob yog 12 hnub.

Yog tias muaj mob cerebrovascular nyob rau qib mob loj heev, cov tshuaj no tau txhaj tshuaj rau lub cev (hauv cov tshuaj tsim nyog - 500 mg ib hnub ib zaug rau 10 hnub), tom qab ntawd lawv hloov mus rau kev noj cov tshuaj sab hauv los ntawm 0.5-1 g ib hnub. Qhov dav dav ntawm txoj kev kho yog 4-6 lub lis piam.

Hauv kev ua haujlwm tsis zoo ntawm cov kab mob hlwb, cov tshuaj yog coj qhov ncauj ntawm 0.5-1 g ib hnub. Qhov dav dav ntawm txoj kev kho yog 4-6 lub lis piam. Cov kev kawm ntau yuav raug qhia ib leeg zuj zus 2-3 zaug hauv ib xyoos.

Rau kev mob hlwb thiab lub zog tawm, nws yog tshuaj sab hauv ntawm 250 mg 4 zaug hauv ib hnub. Lub chav kawm ntawm kev kho mob yog 10-14 hnub. Yog tias tsim nyog, txoj kev kho kom rov ua dua tom qab 2-3 lub lis piam.

Kev ncaws pob raug pom zoo kom siv 0.5-1 g 2 zaug ib hnub ua ntej kev cob qhia. Lub sijhawm ntawm kev kawm hauv lub sijhawm npaj yog 14-21 hnub, lub sijhawm sib tw - 10-14 hnub.

Hauv cov kev quav dej cawv ntev, cov tshuaj tau hais tawm los ntawm qhov ncauj ntawm 500 mg 4 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-10 hnub.

Rau cov kab mob plawv yog ib feem ntawm txoj kev kho mob nyuaj, cov tshuaj tau tawm ntawm koob tshuaj 0.5-1 g ib hnub tso (5-10 ml ntawm cov tshuaj txhaj nrog qhov sib zog ntawm 500 mg / 5 ml), qhov ntau zaus siv yog 1-2 zaug hauv ib hnub. Lub sij hawm ntawm kev kho mob yog 4-6 lub lis piam.

Yog tias muaj teeb meem ntawm cerebrovascular nyob rau theem mob hnyav, qhov tshuaj no tau muab tshuaj rau 500 500 mg ib hnub ib zaug rau 10 hnub, tom qab ntawd lawv hloov mus rau kev noj cov tshuaj hauv (hauv cov ntawv tsim nyog, 0.5-1 g ib hnub). Qhov dav dav ntawm txoj kev kho yog 4-6 lub lis piam.

Thaum vascular pathology thiab dystrophic retinal kab mob, Mildronate tau muab tshuaj parabulbarly rau hauv 0.5 ml tov rau txhaj nrog qhov siab ntawm 500 mg / 5 ml rau 10 hnub.

Txog kev mob hlwb thiab lub cev, iv yog tau txhaj tshuaj 500 mg ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-14 hnub. Yog tias tsim nyog, txoj kev kho kom rov ua dua tom qab 2-3 lub lis piam.

Hauv cov cawv cawv ntev ntev, cov tshuaj tau raug txiav txim iv 500 mg 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-10 hnub.

Sab sij huam

• tachycardia
• hloov ntshav siab
• psychomotor ntxhov siab,
• mob taub hau
• Cov tsos mob dyspeptic
• kev ua xua (liab ntawm daim tawv nqaij, tawm pob lossis ua pob xoo, khaus ntawm daim tawv nqaij, o tuaj),
• feem ntau tsis muaj zog
• o tuaj.

Cov Yuav Tsum Muaj

• nce siab intracranial (suav nrog qee qhov cuam tshuam ntawm cov leeg tawm, cov leeg hlav),
• cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo,
• hypersensitivity rau cov tshuaj.

Cev xeeb tub thiab lactation

Kev nyab xeeb ntawm kev siv Mildronate thaum cev xeeb tub tsis tau muaj pov thawj. Txhawm rau kom tsis txhob muaj qhov tsis zoo tshwm sim ntawm tus me nyuam hauv plab, cov tshuaj yuav tsum tsis txhob siv tshuaj thaum cev xeeb tub.

Nws tsis paub meej tias cov tshuaj puas tawm hauv cov kua mis. Yog tias nws yuav tsum tau siv Mildronate thaum lactation, pub mis rau noj yuav tsum tsis ua ntxiv mus.

Cov lus qhia tshwj xeeb

Cov neeg mob uas muaj mob rau daim siab thiab lub raum yuav tsum ua tib zoo siv lub sijhawm ntev ntawm kev siv tshuaj. Yog tias koj xav tau kev siv tshuaj ntev (ntau tshaj li ib hlis) siv tshuaj, koj yuav tsum sab laj nrog cov kws kho mob tshwj xeeb.

Ntau xyoo ntawm cov kev paub hauv kev kho mob ntawm tus mob myocardial infarction thiab tsis khov nyob rau hauv lub chaw kho mob plawv qhia tias Mildronate tsis yog thawj cov tshuaj rau cov mob ntsig txog tus mob txha caj qaum.

Kev Siv Khomob

Hauv cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, qhov ua tau zoo thiab kev nyab xeeb ntawm Mildronate ua tus tsiav tshuaj thiab kev txhaj tshuaj tsis tau teeb tsa.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tsis muaj pov thawj dab tsi txog kev cuam tshuam zoo ntawm Mildronate ntawm tus nqi ntawm kev xav txog psychomotor.

Yeeb tshuaj sib cuam tshuam

Thaum ua ke, Mildronate txhim kho qhov kev txiav txim ntawm cov tshuaj antianginal, qee cov tshuaj tiv thaiv kabmob ntshav, mob glycosides.

Mildronate tuaj yeem ua ke nrog cov tshuaj tiv thaiv antianginal, tshuaj anticoagulants thiab antiplatelet, tshuaj antiarrhythmic, diuretics, bronchodilators.

Thaum ua ke nrog Mildronate nitroglycerin, nifedipine, alpha-blockers, antihypertensive tshuaj thiab peripheral vasodilators, tachycardia muaj mob me me, cov hlab ntsha hypotension tuaj yeem tsim (ceeb toom yuav tsum tau siv thaum siv kev sib xyaw no).

Analogs ntawm cov tshuaj Mildronate

Cov qauv ntawm cov qauv ua haujlwm:

• 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate,
• Vasomag,
• Idrinol
• Cardionate
• Medatern
• Meldonium,
• Meldonius Eskom
• Meldonium dihydrate,
• Melfort,
• Midolat
• Trimethylhydrazinium propionate dihydrate.

Dosage daim ntawv

Ib qho tshuaj ntsiav muaj

cov tshuaj heev - meldonium dihydrate 500 mg,

zam txim: cov qos yaj ywm hmoov txhuv nplej siab, colloidal silicon dioxide, calcium stearate,

tsiav tshuaj (lub cev thiab lub hau): titanium dioxide (E 171), nkaws.

Zog gelatin tsiav tshuaj No. 00 dawb. Cov ntsiab lus yog xim dawb crystalline hmoov nrog qhov tsaus muag. Lub hmoov yog hygroscopic.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab muab cov ncauj lus tshaj tawm ntawm meldonium, qhov siab tshaj plaws ntshav plasma concentration (Cmax) thiab thaj chaw hauv qab qhov ntsuas-lub sijhawm nkhaus (AUC) nce ntxiv hauv kev faib ua feem rau cov koob tshuaj thov. Lub sijhawm kom mus txog qhov siab tshaj plaws ntshav plasma concentration (tmax) yog 1-2 teev. Nrog kev siv ntau zaus, qhov sib npaug ntawm cov ntshav plasma concentration tau tiav hauv 72-96 teev tom qab thov thawj zaug. Kev sib txuam ntawm meldonium hauv cov ntshav ntshav yog tau. Khoom noj ua rau qeeb dua qhov nqus ntawm meldonium yam tsis hloov Cmax thiab AUC.

Meldonium los ntawm cov ntshav ntws ceev ceev kis mus rau cov ntaub so ntswg. Plasma protein khi ntxiv nrog rau lub sijhawm tom qab kev tswj hwm koob tshuaj. Meldonium thiab nws cov metabolites ib nrab kov yeej cov teeb meem placental. Cov kev tshawb fawb txog kev tawm ntawm meldonium hauv tib neeg cov kua mis niam tsis tau ua.

Meldonium tsuas yog metabolized hauv lub siab.

Kev tsis pom lub raum ua lub luag haujlwm tseem ceeb hauv kev nthuav tawm ntawm meldonium thiab nws cov khoom noj khoom haus. Qhov kev tshem tawm ib nrab-lub neej ntawm meldonium (t1 / 2) yog kwv yees li 4 teev. Nrog kev muab tas li, ib nrab-lub neej txawv.

Cov pab pawg neeg tshwj xeeb

Cov neeg laus cov neeg mob

Qhov koob tshuaj meldonium yuav tsum tau txo nyob rau hauv cov neeg laus cov neeg muaj lub siab tsis zoo los yog lub raum tsis ua haujlwm, uas muaj qhov pom tseeb hauv kev tuaj yeem.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Cov neeg mob uas lub raum tsis ua haujlwm, uas muaj qhov pom tseeb hauv kev tuaj yeem, yuav tsum txo qhov koob. Muaj kev cuam tshuam ntawm lub raum reabsorption ntawm meldonium los yog nws cov metabolites (piv txwv li, 3 - hydroxymeldonium) thiab carnitine, vim qhov kev txiav txim siab ntxiv rau cov carnitine nce. Tsis muaj kev cuam tshuam ncaj qha ntawm meldonium, GBB, thiab kev sib xyaw ntawm meldonium / GBB ntawm lub renin-angiotensin-aldosterone system.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo, uas muaj lub zog ua kom pom tseeb dua, yuav tsum txo cov koob tshuaj meldonium. Kev hloov pauv ntawm cov cim qhia ua haujlwm ntawm daim siab hauv tib neeg tom qab kev siv tshuaj ntawm 400-800 mg tsis tau pom. Qhov kev cuam tshuam ntawm cov rog rau hauv lub siab ua tsis tau yog txoj cai.

Tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb thiab kev ua haujlwm ntawm kev siv meldonium hauv cov menyuam yaus thiab cov hluas (hnub nyoog qis dua 18 xyoo), yog li kev siv meldonium hauv pawg neeg mob no yog sib kis.

Cov Tshuaj Hauv Tshuaj

Meldonium yog tus ua ntej rau carnitine, tus yam ntxwv sib piv ntawm gamma-butyrobetaine (GBB), hauv uas ib cov pa roj carbon atom hloov los ntawm nitrogen atom.

Nyob rau hauv cov xwm txheej ntawm qhov nce ntawm lub nra, meldonium rov qab qhov sib npaug ntawm kev xa thiab cov pa oxygen thov ntawm cov hlwb, tshem tawm cov kev txuam nrog cov khoom lag luam zoo hauv cov hlwb, tiv thaiv lawv los ntawm kev puas tsuaj, thiab tseem muaj cov nyhuv tonic. Raws li kev siv, lub cev tau txais lub peev xwm los tiv thaiv lub nra thiab ceev ceev lub zog txuag. Vim tias cov khoom no, meldonium siv los kho ntau yam mob ntawm cov hlab plawv, cov ntshav mus rau lub hlwb, nrog rau kev ua kom lub cev thiab lub hlwb zoo. Raws li qhov txo qis hauv carnitine concentration, GBB, uas muaj vasodilating khoom, yog sib zog ua ke. Thaum raug mob ischemic tsis zoo rau lub myocardium, meldonium qeeb qeeb qhov kev tsim ntawm thaj chaw necrotic thiab ua kom lub sijhawm rov ua kom sai. Nrog rau lub plawv tsis ua haujlwm, nws nce myocardial contractility, nce kev qoj ib ce zam, thiab txo qis zaus ntawm kev mob taub hau. Hauv kev mob siab thiab mob ntsws ischemic mob hlwb cerebral ncig txhim kho cov ntshav ncig hauv kev ua kom pom tseeb ntawm ischemia, pab txhawb txoj kev rov faib cov ntshav hauv kev pom zoo ntawm thaj chaw ischemic. Cov kev mob puas hlwb (tom qab mob cerebrovascular, kev ua haujlwm ntawm lub hlwb, raug mob taub hau, zuam los yog mob hlwb), nws muaj kev cuam tshuam zoo rau kev rov ua haujlwm ntawm lub cev thiab kev txawj ntse thaum lub sijhawm rov qab los.

Kev ntsuas rau siv

Hauv txoj hauv kev kho mob hauv cov xwm txheej hauv qab no:

kab mob ntawm cov kab mob hauv lub plawv thiab ntshav khov: lub qog npau taws khov kho, lub plawv tsis ua haujlwm (I-III ua haujlwm chav kawm NYHA), kev kho plawv, ua haujlwm tsis zoo ntawm lub plawv thiab vascular system,

mob thiab mob ischemic mob hlwb tsis txaus ntawm lub hlwb,

qhov kev ua haujlwm tsawg, lub cev thiab lub hlwb-siab ntsws dhau los,

thaum lub sij hawm rov qab los ntawm cerebrovascular cuam tshuam, mob taub hau thiab mob rau daim tawv nqaij.

Tsuas tshuaj thiab tswj hwm

Thov sab hauv. Cov tshuaj ntsiav tau nqos nrog dej. Cov tshuaj yuav siv tau ua ntej lossis tom qab noj mov. Hauv kev sib txuas nrog lub peev xwm ua kom lub zog xav tau, cov tshuaj tau pom zoo kom siv thaum sawv ntxov.

Cov neeg laus

Kab mob ntawm lub plawv thiab ntshav vias system,circulatory ntshawv siab

Qhov koob tshuaj yog 500-1000 mg rau ib hnub. Cov koob tshuaj txhua hnub tuaj yeem siv tag nrho ib zaug lossis faib ua ob zaug ib zaug. Qhov nyiaj pab ntau tshaj txhua hnub yog 1000 mg.

Kev ua haujlwm tsawg, ua haujlwm dhau thiab thim rov qab

Qhov koob tshuaj yog 500 mg rau ib hnub. Qhov nyiaj pab ntau tshaj txhua hnub yog 500 mg.

Lub sijhawm tiv thaiv yog 4-6 lub lis piam. Lub chav kawm ntawm kev kho mob tuaj yeem rov ua 2-3 zaug hauv ib xyoos.

Cov neeg laus cov neeg mob

Cov neeg laus uas lub siab tsis ua haujlwm thiab lub raum tsis ua haujlwm yuav xav tau kom txo qis dua ntawm meldonium.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Txij li thaum cov tshuaj tau tawm hauv ob lub raum, cov neeg mob uas tsis zoo los ntawm lub raum los ntawm mob sib khuav mus rau mob hnyav yuav tsum siv qis dua ntawm meldonium.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Cov neeg mob uas mob me me mus rau mob nyhav hepatic yuav tsum siv cov tshuaj meldonium qis dua.

Kev saib xyuas cov menyuam yaus

Tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb thiab kev ua haujlwm ntawm kev siv meldonium hauv cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, yog li kev siv cov tshuaj no rau menyuam yaus thiab tub ntxhais hluas yog contraindicated.

Sab sij huam

- Kev ua haujlwm siab, qhov ua xua tuaj yeem, ua pob khaus (dav dav / macular / papular), khaus, urticaria, angioedema, phiv tshuaj anaphylactic

- Ua haujlwm tsis zoo, muaj kev ntshai, ntshai xav, xav pw tsis tsaug zog

- paresthesia, hypesthesia, tinnitus, vertigo, kiv taub hau, gait ntxhov siab, tsaus muag, tsis nco qab

- lub plawv hloov pauv, txhaws ntsej muag, mob tachycardia / mob ntsws tachycardia, atrial fibrillation, arrhythmia, mob hauv siab / mob hauv siab

- kev hloov pauv hauv ntshav siab, kub siab tawg, hyperemia, pallor ntawm daim tawv nqaij

- mob caj pas, hnoos, dyspnea, apnea

- mob plab tsis txaus (lub plab muaj qhov ncauj hauv qhov ncauj), tsis qab los noj mov, ntuav, xeev siab, ntuav, tso cov pa nkev, raws plab, mob plab, - rov mob, mob leeg, mob leeg

- kev ua kom tsis muaj zog ntau, tshee hnyo, asthenia, edema, o ntawm lub ntsej muag, o ntawm ob txhais ceg, qhov hnov ​​ntawm tshav kub, hnov ​​ntawm txias, tawm hws

- kev hloov pauv hauv lub electrocardiogram (ECG), kev ua kom sai ntawm lub siab, eosinophilia

Cov Yuav Tsum Muaj

- Hypersensitivity rau cov tshuaj nquag lossis lwm yam tshuaj pabcuam ntawm cov tshuaj.

- nce nyob rau hauv intracranial siab (nyob rau hauv kev ua txhaum ntawm venous outflow, hlav hlav intracranial).

- muaj mob hepatic thiab / lossis lub raum tsis ua haujlwm vim tias tsis muaj cov ntaub ntawv kev nyab xeeb.

- cev xeeb tub thiab lactation, vim tias tsis muaj cov ntaub ntawv hais txog kev siv tshuaj kho mob rau lub sijhawm no.

- cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, vim tias tsis muaj ntaub ntawv qhia txog kev kho mob kev siv tshuaj rau lub sijhawm no.

Cov tshuaj sib cuam tshuam

Txhim kho cov txiaj ntsig ntawm coronary dilating agents, qee cov tshuaj tiv thaiv kabmob ntshav siab, mob plawv glycosides.

Nws tuaj yeem ua ke nrog cov tshuaj antianginal, anticoagulants, antiplatelet agents, antiarrhythmic tshuaj, diuretics, bronchodilators.

Meldonium tuaj yeem txhim kho cov nyhuv ntawm cov tshuaj muaj glyceryl trinitrate, nifedipine, beta-blockers, lwm yam tshuaj tiv thaiv kab mob siab, thiab peripheral vasodilators.

Hauv cov neeg mob uas muaj mob plawv tsis zoo noj meldonium thiab lisinopril tib lub sijhawm, cov txiaj ntsig zoo ntawm kev sib xyaw ua ke tau qhia tawm (vasodilation ntawm cov hlab ntsha tseem ceeb, txhim kho peripheral ncig thiab lub neej zoo, txo kev puas hlwb thiab lub cev).

Thaum siv meldonium nyob rau hauv kev sib xyaw nrog orotic acid kom tshem tawm kev puas tsuaj los ntawm ischemia / reperfusion, ib qho ntxiv pharmacological nyhuv tau pom.

Raws li tau siv los ua ib txhij Sorbifer thiab meldonium hauv cov neeg mob uas tsis muaj cov ntshav tsis txaus, qhov muaj pes tsawg leeg ntawm cov rog rog hauv cov ntshav liab tau nce zoo tuaj.

Meldonium pab tshem tawm txoj kev hloov pauv hauv lub plawv los ntawm azidothymidine (AZT), thiab tsis ncaj qha rau kev cuam tshuam oxidative kev nyuaj siab tshwm sim los ntawm AZT, ua rau mitochondrial kawg. Kev siv cov meldonium hauv kev sib xyaw nrog AZT lossis lwm yam tshuaj rau kev kho mob ntawm kev txhaj tshuaj tiv thaiv kab mob (AIDS) tau muaj txiaj ntsig zoo rau kev kho tus mob AIDS.

Hauv kev kuaj xyuas kev ua kom haum ethanol tsis nco qab, meldonium txo qis lub sijhawm pw tsaug zog. Thaum lub sij hawm qaug dab peg tshwm sim los ntawm pentylenetetrazole, lub suab anticonvulsant ntawm meldonium tau tsim los. Nyeg, thaum α-adrenoblocker yohimbine ntawm koob tshuaj 2 mg / kg thiab N- (G) -nitro-L-arginine synthase inhibitor ntawm ib koob ntawm 10 mg / kg yog siv ua ntej kev kho mob nrog meldonium, cov nyhuv anticonvulsant ntawm meldonium yog tag sim. Cov.

Kev noj tshuaj ntau tshaj ntawm meldonium tuaj yeem txhim kho cardiotoxicity tshwm sim los ntawm cyclophosphamide.

Cov carnitine tsis txaus uas tshwm sim los ntawm kev siv D-carnitine (tus kws kho mob tsis sib haum tshuaj isomer) -meldonium tuaj yeem txhim kho lub cardiotoxicity tshwm sim los ntawm ifosfamide.

Meldonium muaj kev tiv thaiv zoo yog tias cardiotoxicity tshwm sim los ntawm indinavir thiab neurotoxicity tshwm sim los ntawm efavirenz.

Vim tias txoj kev txhim kho tau ntawm tachycardia thiab kev mob ntshav qis, yuav tsum tau ceev faj thaum siv nrog cov tshuaj uas muaj tib yam, nrog rau lwm cov tshuaj muaj meldonium.

Cov lus qhia tshwj xeeb

Nrog kev siv lub sijhawm ntev ntawm cov tshuaj, cov neeg mob mob siab thiab mob raum yuav tsum ua tib zoo (daim siab thiab / lossis lub raum ua haujlwm tshuaj xyuas yuav tsum tau ua).

Meldonium tsis yog thawj qhov tshuaj rau kev mob caj dab.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb lossis cov phom sij phom sij

Ceev faj yuav tsum tau siv thaum tsav tsheb lossis lub tshuab khoom muaj kev phom sij.

Noj ntau dhau

Cov mob ntawm kev noj haus ntau tshaj nrog meldonium tsis paub meej, cov tshuaj muaj tshuaj lom tsawg.

Nrog rau cov ntshav siab qis, mob taub hau, kiv taub hau, tachycardia, thiab tsis muaj zog txhua yam yog ua tau.

Yog tias muaj kev haus ntau dhau, nws yog ib qho tsim nyog los tswj lub luag haujlwm ntawm daim siab thiab lub raum.

Vim yog qhov kev pom zoo khi ntawm cov tshuaj rau cov protein, hemodialysis tsis tseem ceeb.

Chaw tsim tshuaj paus

JSC "Grindeks", Latvia

Chaw nyob ntawm lub koom haum tswj hwm thaj chawKoom pheej ntawm Kazakhstan thov los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo

Sawv cev ntawm JSC "Grindeks"

050010, Almaty, Dostyk Ave., kaum ntawm ul. Bogenbai Batyr, d. 34a / 87a, chaw ua haujlwm No. 1

Cov Tshuaj Hauv Tshuaj

Meldonium (MILDRONAT ®) yog cov yam ntxwv ntawm gamma-butyrobetaine - cov tshuaj uas pom muaj hauv txhua lub cell ntawm tib neeg lub cev.

Nyob rau hauv cov xwm txheej ntawm qhov nce ntawm lub nra, MILDRONAT ® rov qab qhov sib npaug ntawm kev xa thiab oxygen thov ntawm cov hlwb, tshem tawm cov kev txuam nrog kev lom cov khoom lag luam hauv cov hlwb, tiv thaiv lawv los ntawm kev puas tsuaj, thiab tseem muaj cov txiaj ntsig tonic. Raws li kev siv, lub cev tau txais lub peev xwm los tiv thaiv lub nra thiab ceev ceev lub zog txuag.

Vim tias cov khoom zoo no, cov tshuaj MILDRONAT ® yog siv los kho ntau yam mob ntawm CVS, muab ntshav rau lub hlwb, ntxiv rau ua kom lub cev thiab lub hlwb ua haujlwm. Raws li qhov txo qis hauv carnitine concentration, gamma-butyrobetaine nrog vasodilating cov khoom yog qhov sib zog ua ke. Thaum raug mob ischemic tsis zoo rau lub myocardium, cov tshuaj MILDRONAT ® ua rau qeeb qhov tsim ntawm thaj chaw necrotic thiab ua kom lub sijhawm rov ua kom sai. Nrog rau lub plawv tsis ua haujlwm, nws nce myocardial contractility, nce kev qoj ib ce zam, thiab txo qis zaus ntawm kev mob taub hau. Hauv kev mob ntsws thiab mob ntsws ischemic mob hlwb ntawm cov ntshav hlwb, cov tshuaj MILDRONAT ® txhim kho cov ntshav ncig hauv kev ua kom pom tseeb ntawm ischemia, txhawb kev faib tawm cov ntshav kom haum rau thaj chaw ischemic. Cov tshuaj tshem tawm cov kev ua haujlwm tsis zoo ntawm cov hlab ntsha hauv cov neeg mob uas qaug cawv ntev nrog kev tshem tawm mob.

Kev taw qhia ntawm cov tshuaj MILDRONAT ®

txoj kev kho mob ntsig txog txoj kev mob plawv (angina pectoris, myocardial infarction),

mob plawv tsis ua hauj lwm thiab kev mob plawv rau ntawm keeb kwm yav dhau los ntawm cov khoom noj tsis haum,

ua kev kho mob nyuaj los ntawm cov mob thiab mob mus ntev rau cov ntshav mus rau lub hlwb (mob hlab ntsha tawg thiab ntshav tsis txaus),

hemophthalmus thiab retinal hemorrhages ntawm ntau yam etiologies, thrombosis ntawm central retinal leeg thiab nws cov ceg, retinopathy ntawm ntau etiologies (mob ntshav qab zib, kub siab),

kev xav thiab lub cev nyhav dhau los (suav nrog cov neeg ncaws pob) (cov tshuaj tuaj yeem ua rau muaj txiaj ntsig zoo thaum muaj kev tswj hwm doping (saib. "Cov lus qhia tshwj xeeb"),

ntsoos ntsoos mob rau kev haus cawv ntev (nrog rau kev kho rau kev haus dej cawv).

Cev xeeb tub thiab lactation

Kev nyab xeeb ntawm kev siv hauv cov poj niam cev xeeb tub tsis tau kawm txog, yog li siv yog contraindicated kom tsis txhob muaj kev phiv tshuaj ntawm cov menyuam hauv plab.

Kev rho tawm cov tshuaj MILDRONAT ® nrog rau mis nyuj thiab nws cov txiaj ntsig ntawm kev noj qab haus huv ntawm tus menyuam tshiab tseem tsis tau kawm, yog li ntawd, yog tias tsim nyog, yuav tsum pub mis rau niam mis.

Kev sib txuam

Nws tuaj yeem ua ke nrog cov tshuaj antianginal, anticoagulants, antiplatelet agents, antiarrhythmic tshuaj, diuretics, bronchodilators.

Txhim kho qhov kev txiav txim ntawm cov mob glycosides.

Hauv kev pom txog qhov kev txhim kho tau ntawm tachycardia thiab kev mob ntshav ntawm lub plawv, kev ceev faj yuav tsum tau siv thaum ua ke nrog nitroglycerin, nifedipine, alpha-blockers, lwm cov tshuaj tiv thaiv kev tiv thaiv thiab peripheral vasodilators, vim tias MILDRONAT ® txhim kho lawv cov nyhuv.

Daim ntawv tso tawm

Kev daws rau cov tshuaj intramuscular, tshuaj pleev ib ce thiab parabulbar, 100 mg / ml. 5 ml hauv lub vial ntawm cov iav tsis muaj kob ntawm hydrolytic chav I nrog kab lossis tawg taw tes.

5 amp txhua. hauv cov xovtooj ntawm ntim ua los ntawm PVC zaj duab xis lossis uncoated PET zaj duab xis (pallet). Ntawm 2 lossis 4 (tsuas yog rau cov neeg tsim khoom ntawm ZAO Santonika thiab HSBC Pharma sro) ntawm lub ntim cov thawv ntim khoom (cov khoom nqa) rau hauv cov pob ntawv los qhia.