Acetylsalicylic acid: cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Acetylsalicylic acid, thaum noj, ua rau cuam tshuam kev cuam tshuam ntawm cov synthesis ntawm prostaglandins, cov tshuaj uas ua lub luag haujlwm tseem ceeb hauv kev txhim kho febrile xeev, cov txheej txheem mob thiab mob.

Kev tsuj tawm ntawm kev tsim cov tshuaj prostaglandins ua rau kev nthuav dav ntawm cov hlab ntshav, uas pab txhawm rau txhim kho kev sib cais ntawm hws, uas piav qhia lub zog antipyretic ntawm cov tshuaj.

Kev siv cov tshuaj raws li cov tshuaj acetylsalicylic acid hauv kev kho ua rau txo qis ntawm qhov tsis hnov mob ntawm cov hlab hlwb, uas piav qhia txog lub suab analgesic nyhuv ntawm cov tshuaj no. Acetylsalicylic acid yog tawm ntawm lub raum.

Dab tsi pab kom acetylsalicylic acid

Acetylsalicylic acid ntsiav tshuaj raug muab rau cov neeg laus los kho thiab tiv thaiv cov mob hauv qab no:

Cov mob ua haujlwm sai - mob ntawm lub plawv lub hnab, mob caj dab, mob caj dab me, mob ntsws nqig ntshav thiab pleurisy ua ib feem ntawm txoj kev kho mob, mob txhab ntawm lub hnab periarticular,
Kev mob los ntawm ntau qhov keeb kwm - mob taub hau heev, mob hniav, mob nqaij mob khaub thuas thiab mob khaub thuas, mob khaub ncaws, mob taub hau, mob pob txha,
Cov kab mob pob txha dhau los nrog mob hnyav - osteochondrosis, lumbago,
Kev nce hauv lub cev kub, kub taub hau vim kis thiab cov txheej txheem hauv lub cev,
Kev tiv thaiv ntawm kev txhim kho ntawm myocardial infarction lossis ischemic stroke nyob rau hauv rooj plaub ntawm kev mob ntshav ncig, thromboaggregation, ntshav tuab heev,
Angina pectoris ntawm kev tsis ruaj khov,
Caj dab tsi tshwm sim rau tus mob thromboembolism, thrombophlebitis,
Lub plawv tsis ua haujlwm, mitral valve prolapse (impaired functioning),
Mob ntsws hauv lub ntsws, pulmonary thromboembolism.

Cov Yuav Tsum Tau Ua

Acetylsalicylic acid ntsiav tshuaj muaj ib tug xov tooj ntawm contraindications rau siv. Cov no suav nrog:

Hemorrhagic diathesis thiab vasculitis,
Gastritis ntawm erosive los yog corrosive keeb kwm,
Peptic rwj ntawm lub plab thiab duodenum,
Kev tsis zoo ntshav coagulability, ntshav txaus nyiam,
Vitamin K tsis txaus
Dhau ntawm Aortic Aneurysm,
Kev mob tsis zoo hauv lub raum thiab lub siab ua haujlwm,
Hemophilia
Tus kheej tsis kam rau salicylates lossis kev ua xua rau acetylsalicylic acid hauv keeb kwm
Arterial hypertension, qhov kev pheej hmoo ntawm hemorrhagic mob stroke.

Acetylsalicylic acid yuav noj li cas?

Acetylsalicylic acid ntsiav tshuaj yog rau kev tswj hwm qhov ncauj. Cov tshuaj yog pom zoo kom noj thaum pib noj mov lossis tam sim ntawd tom qab noj mov kom tiv thaiv kev txhim kho ntawm yaig ntawm lub plab hnyuv. Cov ntsiav tshuaj tuaj yeem muab ntxhua nrog mis nyuj, yog li cov nyhuv ua tsis haum ntawm acetylsalicylic acid rau ntawm cov qog ua kua ntawm lub plab zom mov yuav tsis muaj kev txhoj puab heev lossis siv cov dej alkaline tsis muaj roj hauv qhov ntau.

Cov neeg laus tau noj tshuaj 1 ntsiav tshuaj 500 mg ntawm 2-4 zaug hauv ib hnub, nyob ntawm qhov ntsuas thiab kev noj qab haus huv feem ntau. Qhov koob tshuaj txhua hnub ntau yog 3 g thiab tsis tuaj yeem dhau! Lub sijhawm ntawm kev kho nrog cov tshuaj no yog txiav txim los ntawm tus kws kho mob nyob ntawm qhov ntsuas, qhov mob ntawm cov txheej txheem mob thiab tus kheej ntawm lub cev, tab sis lub sijhawm no yuav tsum tsis pub tshaj 10-12 hnub.

Rau cov laj thawj prophylactic, kom txo qis kev pheej hmoo ntawm kev tsim myocardial infarction thiab thromboaggregation, cov neeg laus raug xaj ½ cov tshuaj aspirin 1 zaug hauv ib hnub. Lub sijhawm kho yog li 1-2 lub hlis. Nyob rau lub sijhawm no, nws yog ib qhov tsim nyog los soj ntsuam cov duab hauv ntshav, saib xyuas tus lej ntawm cov ntshav coagulation thiab cov lej ntawm cov ntshav platelets.

Sab sij huam

Ua ntej siv cov ntsiav tshuaj acidylsalicylic acid, tus neeg mob yuav tsum sab laj nrog kws kho mob. Yog tias cov koob tshuaj tau ntau dua lossis kev tswj tsis tau thiab siv sijhawm ntev los ntawm cov tshuaj no, cov kev mob tshwm sim hauv qab no tuaj yeem tsim:

Epigastric mob, xeev siab, ntuav,
Zawv plab
Kiv taub hau thiab tsis muaj zog
Tsis qab los noj mov
Pom kev puas,
Los ntshav - hnyuv, qhov ntswg, gingival, pais plab,
Kev hloov pauv hauv cov duab hauv ntshav ntawm ntshav - txo qis cov ntshav hemoglobin thiab platelets,
Ua txhaum ntawm daim siab thiab lub raum,
Kev txhim kho ntawm lub raum tsis ua haujlwm,
Bronchospasm, hauv qhov xwm txheej loj, kev txhim kho ntawm kev mob hlwb thiab mob anaphylactic.

Kev siv cov tshuaj thaum cev xeeb tub thiab lactation

Cov tshuaj acetylsalicylic acid yog txwv tsis pub noj hauv 1st thiab 3rd trimesters thaum cev xeeb tub.

Raws li kev tshawb fawb, kev siv tshuaj aspirin ntsiav tshuaj hauv cov poj niam cev xeeb tub hauv thawj 12 lub lis piam heev ua rau muaj kev pheej hmoo ntawm kev tsim muaj qhov txawv txav ntawm lub cev, uas yog, tawg ntawm lub sab qaum thiab lub plawv tsis zoo.

Kev siv cov tshuaj hauv lub hlis thib ob yog ua tau nrog kev ceev faj thiab tsuas yog tias xav tias yuav muaj txiaj ntsig rau leej niam yuav siab dua qhov ua rau muaj mob rau hauv lub cev hauv plab. Cov ntsiav tshuaj yog siv hauv cov kev noj tshuaj kom nruj me ntsis (siv tau tsawg kawg nkaus) thiab hauv qab kev tswj hwm nruj. Thaum lub sijhawm kev kho mob, cov niam cev xeeb tub yuav tsum tau kuaj ntshav tas li kom ntsuas cov ntshav hematocrit thiab cov ntshav txhaws.

Kev siv cov tshuaj acetylsalicylic acid nyob rau hauv peb lub hlis thib 3 yog txwv vim muaj kev pheej hmoo loj ntawm kev kaw ntxov ntawm aortic duct hauv tus menyuam. Ib qho ntxiv, cov tshuaj yuav ua rau cov ntshav nyob rau hauv lub ventricles ntawm lub paj hlwb hauv tus me nyuam hauv plab thiab ua rau muaj kev pheej hmoo ntawm los ntshav ntau hauv cov niam uas tseem tos.

Kev siv cov tshuaj acetylsalicylic acid lub sijhawm noj niam mis yog qhov txwv tsis pub vim muaj qhov pheej hmoo ntawm lub siab thiab lub raum tsis ua haujlwm hauv tus menyuam. Ib qho ntxiv, kev nkag mus rau hauv lub cev ntawm menyuam mos nrog niam cov kua mis, acetylsalicylic acid tuaj yeem ua rau muaj ntshav tawm hauv lub cev heev hauv menyuam yaus. Yog tias nws yuav tsum tau siv cov tshuaj no thaum pub niam mis, tus menyuam yuav tsum pauv mus rau qhov khoom noj uas tsis haum nrog mis hloov.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv cov tshuaj aspirin sib xyaw nrog lwm cov tshuaj los ntawm cov pab pawg ntawm cov tshuaj uas tsis yog tshuaj steroidal (ibuprofen, nuroferon, indomethacin thiab lwm tus) nce qhov kev pheej hmoo ntawm kev phiv uas teev saum toj no thiab cov tsos mob overdose. Muaj qee kis, cov neeg mob tsim muaj tus mob hepatic thiab lub raum khiav tsis zoo thiab tsis nco qab.

Nrog rau kev siv tib txhij ntawm acetylsalicylic acid thiab tshuaj los ntawm pawg antacid, ib qho kev txo qis hauv kev kho mob ntawm cov tshuaj aspirin thiab ib qho kev poob qis hauv nws txoj kev nqus mus rau hauv cov hlab ntshav tau pom.

Acetylsalicylic acid ntsiav tshuaj txwv tsis pub noj ib txhij nrog tshuaj anticoagulants vim tias qhov nce siab yuav ua rau muaj kev pheej hmoo sab hauv los ntshav heev thiab ntshav ntau.

Nrog rau txoj kev sib txig siv cov tshuaj acetylsalicylic acid nrog diuretics, lawv txoj kev kho ua kom tsawg dua.

Kev siv cov tshuaj ib txhij nrog ethanol tuaj yeem ua rau lom thiab qaug rau hauv lub cev.

Cia thiab xa tawm ntawm cov neeg mob

Cov ntsiav tshuaj Acetylsalicylic acid tau muab faib hauv cov tsev muag tshuaj yam tsis muaj tshuaj. Cov tshuaj yuav tsum khaws cia 4 xyoos txij li hnub ntawm kev tsim khoom qhia ntawm pob. Tom qab lub sijhawm no, cov ntsiav tshuaj tsis tuaj yeem noj ntawm qhov ncauj.

Khaws lub ntim cia kom deb ntawm kev tshav ntuj ncaj qha thiab kom deb ntawm cov menyuam yaus.

Dosage daim ntawv

Ntsiav tshuaj, 500 mg

Ib ntsiav tshuaj muaj

yam tshuaj: acetylsalicylic acid - 500 mg

tus zam: qos yaj ywm hmoov txhuv nplej siab, stearic acid, citric acid monohydrate, talc

Pav-cylindrical ntsiav tshuaj, dawb, chamfered thiab notched, me ntsis marble

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, acetylsalicylic acid hloov mus rau hauv lub ntsiab metabolite - salicylic acid. Kev nqus ntawm acetylsalicylic thiab salicylic acids nyob rau hauv cov hnyuv tshwm sim sai thiab tag nrho. Qhov siab tshaj plaws ntshav plasma yog nce mus txog tom qab 10-20 feeb (acetylsalicylic acid) lossis 45-120 feeb (tag nrho salicylates). Qhov kev khi ntawm cov kua qaub ntawm cov kua qaub los ntawm cov ntshav plasma protein yog nyob ntawm qhov kev xav, uas yog 49-70% rau acetylsalicylic acid thiab 66-98% rau salicylic acid. 50% kev noj tshuaj ntawm cov tshuaj yog metabolized thaum lub sijhawm pib nkag los ntawm lub siab.

Cov tshuaj hla cov ntshav-hlwb teeb meem, thiab kuj tau txiav txim siab nyob rau hauv niam mis thiab kua dej synovial.

Metabolites ntawm acetylsalicylic thiab salicylic acids yog glycine conjugate ntawm salicylic acid, gentisic acid thiab nws glycine conjugate. Lub biotransformation ntawm salicylates feem ntau tshwm sim hauv lub siab nrog kev tsim ntawm 4 lub ntsiab metabolites pom nyob rau hauv ntau cov ntaub so ntswg thiab zis. Kev nthuav tawm ntawm salicylates yog nqa tawm tshwj xeeb los ntawm kev ua kom muaj kev sib haum xeeb hauv cov tubules ntawm lub raum hauv daim ntawv tsis hloov pauv (60%) thiab hauv daim ntawv ntawm metabolites. Tus nqi ntawm kev tso zis yog nyob ntawm qhov koob tshuaj - thaum noj me me, ib nrab lub neej yog 2-3 teev, thiab nrog qhov nce hauv koob nws tuaj yeem nce ntxiv txog 15-30 teev. Hauv cov menyuam mos yug tshiab, kev tshem tawm cov salicylates qeeb qeeb dua li cov laus. Qhov ua rau cuam tshuam los ntawm cov tshuaj tshwm sim tom qab 1-2 hnub ntawm kev tswj hwm (tom qab tsim kev kho tsis tu ncua ntawm salicylates hauv cov ntaub so ntswg, uas yog kwv yees li 150-300 μg / ml), nce mus txog qhov siab kawg ntawm qhov siab ntawm 20-30 mg% thiab tag nrho lub sijhawm siv.

Cov Tshuaj Hauv Tshuaj

Acetylsalicylic acid muaj qhov ua los tiv thaiv, antipyretic, thiab kuj tseem ua haujlwm analgesic.

Cov nyhuv tiv thaiv ntawm acetylsalicylic acid tau piav qhia los ntawm nws cov txiaj ntsig ntawm cov txheej txheem tshwm sim hauv kev tsom xam ntawm qhov mob: qhov txo qis ntawm permeability ntawm capillaries, qhov txo qis ntawm cov dej num ntawm hyaluronidase, kev txwv ntawm lub zog muab ntawm cov txheej txheem inflammatory los ntawm inhibiting tsim ATP, thiab lwm yam.

Antipyretic nyhuv yog cuam tshuam nrog tus cawv rau hypothalamic chaw ntawm thermoregulation.

Cov nyhuv analgesic yog vim muaj cov txiaj ntsig rau cov chaw ntawm qhov mob rhiab thiab qhov muaj peev xwm ntawm salicylates los txo cov algogenic nyhuv ntawm bradykinin.

Ib qho ntawm cov txheej txheem tseem ceeb ntawm kev ua ntawm acetylsalicylic acid yog qhov ua tsis tau (kev tsuj ntawm kev ua si) ntawm cyclooxygenase enzyme (ib qho enzyme koom nrog hauv cov synthesis ntawm prostaglandins), raws li cov txiaj ntsig ntawm cov synthesis ntawm prostaglandins cuam tshuam. Kev ua txhaum ntawm prostaglandin hluavtaws ua rau ua rau qhov kev ploj ntawm qhov ua tau zoo ntawm qhov kawg ntawm cov hlab ntaws mus rau kinins thiab lwm yam kev mob thiab mob los kho tus mob (transmitters). Vim tias qhov kev ua txhaum ntawm kev ua ke ntawm cov tshuaj prostaglandins, qhov mob hnyav thiab lawv cov pyrogenic (nce lub cev kub) ua rau cov thermoregulation chaw tsawg dua. Tsis tas li ntawd, cov txiaj ntsig ntawm prostaglandins ntawm qhov kawg ntawm cov hlab ntshav tau txo qis, uas ua rau muaj kev txo qis hauv lawv cov neeg mob siab rau qhov mob txhim kho. Nws kuj muaj antiaggregatory kev txiav txim.

Cov nyhuv los tiv thaiv kev sib txuam ntawm cov tshuaj yog txo lub peev xwm ntawm platelets thiab lwm cov qe ntshav kom sib sau ua ke thiab txo qhov ua rau muaj qhov tsis txaus ntseeg. Tus txheej txheem ntawm qhov kev ua no tau cuam tshuam nrog kev thaiv ntawm cyclooxygenase txoj hauv kev ntawm arachidonic acid metabolism, kev txwv tsis pub muaj cov enzymes ntawm thromboxane synthetase, phosphodiesterase, kev nce siab hauv cAMP hauv platelets, txo qis hauv qib ntawm calcium intracellular, inhibition of synthesis ntawm prostaglandins thiab endogenous pawg (cov tshuaj tiv thaiv). ib tug heev proaggregation (ua rau platelet aggregation) tau, qhov nce ntawm cov concentration ntawm adenosine hauv cr ova, thaiv ntawm glycoprotein GP IIb / IIIa receptors. Raws li qhov tshwm sim, platelet aggregation yog inhibited, lawv qhov kev tiv thaiv mus rau deformation yog nce ntxiv, rheological zog ntawm cov ntshav tau zoo tuaj, thrombosis yog suppressed, microcirculation yog li qub. Qhov tseem ceeb ntawm kev txwv tsis pub cov nplaum ntawm cov ntshav yog ua tiav ntawm koob tshuaj 30 mg. Tsub ntxiv ntshav fibrinolytic kev ua si thiab txo qhov kev xav ntawm cov vitamin K-dependant cov ntshav coagulation yam. Qhov tsis haum cov kua qaub yog cov tshuaj tua lub cev kom ntau, vim tias nws txoj kev thim rov qab rau hauv lub raum plab yog qhov tsis tuaj yeem.

Kev ntsuas rau siv

mob rheumatic, mob rheumatoid, mob pericarditis, Dressler mob, rheumatic chorea

mob mentsis mus rau mob pes tsawg (nrog rau mob taub hau, mob taub hau, mob taub hau, mob hniav, mob pob txha caj dab, mob caj dab, mob ntshav txiv ntshav, algomenorrhea)

kab mob ntawm caj qaum nrog mob (lumbago, sciatica)

nce lub cev kub rau khaub thuas thiab lwm yam kab mob sib kis thiab mob (hauv cov neeg laus thiab cov menyuam hnub nyoog 15 xyoos dua)

Tsuas tshuaj thiab tswj hwm

Acetylsalicylic acid noj tom qab noj mov nrog kua ntau - kua, mis lossis dej ntxhia.

Nrog cov mob febrile thiab hnov mob nws raug nquahu kom noj 0.25 - 0.5 g / hnub (1 / 2-1 tab.) 3 - 6 zaug hauv ib hnub. Lub sijhawm nruab nrab ntawm cov koob tshuaj yuav tsum yog tsawg kawg 4 teev. Qhov siab tshaj plaws ntau npaum li cas ntawm 1 g. Qhov siab tshaj plaws niaj hnub noj yog 3.0 g.

Yog tias, thaum noj cov tshuaj acetylsalicylic acid rau 5 hnub, qhov hnov mob txhawm rau lossis rau 3 hnub qhov kub taub hau txuas ntxiv, koj yuav tsum tso tseg kev kho mob thiab sab laj nrog kws kho mob.

Sab sij huam

kiv taub hau, plob hau, tsis hnov lus

NSAID mob plab: mob mob epigastric, kub siab, xeev siab, ntuav, ntshav ntau hauv lub plab zom mov

thrombocytopenia, ua haujlwm tsis txaus, leukopenia

Mob Reye / Reye Syndrome (mob caj dab ntxiv: xeev siab thiab ntuav indomitable, ua tsis taus pa, tsaug zog, mob plab, rog rog, hyperammonemia, nce AST, ALT)

kev tsis haum tshuaj: laryngeal edema, bronchospasm, urticaria, "aspirin" bronchial hawb pob thiab "aspirin" triad (eosinophilic rhinitis, ua mob rau lub qhov ntswg polyposis, hyperplastic sinusitis)

Nrog lub caij nyoog siv:

interstitial nephritis, prerenal azotemia nrog nce creatinine nyob rau hauv cov ntshav thiab hypercalcemia, mob raum tsis ua haujlwm, tus mob nephrotic

cov kab mob ntshav (ntshav liab, agranulocytosis, thrombocytopenic purpura)

nce cov tsos mob ntawm congestive plawv nres, edema

nce theem ntawm aminotransferases nyob rau hauv cov ntshav.

Cov tshuaj sib cuam tshuam

Nrog rau kev siv ua ke ntawm acetylsalicylic acid nrog valproic acid npaj, cephalosporins lossis anticoagulants, qhov kev pheej hmoo ntawm los ntshav ntau ntxiv. Nrog rau kev siv thooj txhij ntawm cov tshuaj thiab NSAIDs, lub ntsiab loj thiab phiv ntawm cov tom kawg yog nthuav dav.

Hauv keeb kwm ntawm kev kho mob nrog cov tshuaj, cov kev mob tshwm sim ntawm methotrexate yog qhov phem ntxiv (thaum noj qhov kawg tshaj 15 mg / vas thiv. - Acetylsalicylic acid yog contraindicated).

Nrog rau kev siv ua ke nrog qhov ncauj tshuaj hypoglycemic - sulfonylurea derivatives - muaj qhov nce ntawm cov nyhuv hypoglycemic.

Nrog rau kev siv ua ke nrog glucocorticosteroids, kev siv dej cawv, kev pheej hmoo ntawm lub plab hnyuv nce tuaj.

Cov tshuaj ua rau cov nyhuv tsis muaj zog ntawm spironolactone, furosemide, antihypertensive thiab anti-gout cov neeg sawv cev uas txhawb cov kev zam ntawm uric acid.

Kev tswj hwm ntawm kev siv tshuaj tiv thaiv thaum kho nrog cov tshuaj (tshwj xeeb tshaj yog ntawm ntau tshaj 3.0 g rau cov neeg laus) tuaj yeem ua rau txo qis hauv theem siab ntawm salicylate hauv cov ntshav.

Cov lus qhia tshwj xeeb

Acetylsalicylic acid ua rau muaj kev pheej hmoo los ntshav ntau heev txawm tias noj tsawg dua thiab nyob rau ob peb hnub tom qab noj tas. Ua ntej kev phais mob, qhia rau koj tus kws kho mob, kws phais mob, tshuaj loog lossis kws kho hniav txog kev noj tshuaj Acetylsalicylic acid. 5-7 hnub ua ntej kev phais mob, nws yog ib qho tsim nyog yuav tsum tshem tawm qhov kev txais tos (kom txo qis los ntshav thaum lub sijhawm ua haujlwm thiab tom qab lub sijhawm so tom qab). Thaum kho mob ntev, nws raug nquahu kom kuaj ntshav tas li thiab kuaj cov quav rau cov ntshav muaj ntshav.

Nrog rau kev sib xyaw ua ke nrog kev kho mob nrog acetylsalicylic acid hauv kev txhaj tshuaj me me, uric acid excretion yuav txo qis, uas tuaj yeem ua rau gout.

Kev siv kho cov menyuam yaus Tsis txhob sau cov tshuaj acetylsalicylic acid rau cov menyuam yaus hnub nyoog qis dua 15 xyoos nrog mob voos los ntawm kev kis mob, nrog rau cov kab mob nrog hyperthermia vim qhov phom sij ntawm kev tsim muaj Reye / Ray syndrome).

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb lossis cov phom sij phom sij

Tsis muaj pov thawj tshwm sim tsis zoo ntawm kev ua kom nquag plias, rau kev ua lub cev muaj zog thiab rov ua kom zoo.

Noj ntau dhau

Ckev mob tshwm sim: kiv taub hau, hnov tsis pom kev thiab hnov lus, xeev siab, ntuav, ua pa nyuaj. Tom qab ntawd, muaj kev nyuaj siab ntawm kev nco qab mus txog rau qhov tsis nco qab, ua tsis taus pa, tsis hnov qab cov kua qaub-lub hauv paus kev tshuav nyiaj (ua pa alkalosis, tom qab ntawv metabolic acidosis), mob raum tsis zoo (ARF), poob siab. Kev tuag taus yog qhov ua tau thaum siv ntau li ntawm 200 txog 500 mg / kg.

Kev Kho Mob: ntxias cov ntuav lossis pais plab lav, sau daim ntawv kom ua hluav ncaig, tshuaj pleev plab. Kev kho mob yuav tsum tau nqa tawm hauv cov kws tshaj lij.

Daim ntawv tso tawm thiab ntim khoom

500 mg ntsiav tshuaj

10 ntsiav tshuaj muab tso rau hauv contour bezeljakovoj ntim cov ntawv ntim nrog polyethylene txheej.

100 contour bezjacheykovy ntim nrog rau cov lus qhia sib luag rau kev siv tshuaj hauv xeev thiab Lavxias lus yog muab tso rau hauv lub thawv los ntawm cov thawv ntawv (lub thawv ntim).

Daim Ntawv Tso Npe Sau Npe

Marbiopharm OJSC, Lavxias Federation

Lub chaw nyob ntawm cov koomhaum uas lees txais thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) hauv koom pheej ntawm Kazakhstan

Lavxias Federation, 424006, Koom pheej ntawm Mari El, Yoshkar-Ola,

Xovtooj: (8362) 42-03-12, fax: (8362) 45-00-00

Kws Tshuaj

Nws inhibits cyclooxygenase (COX-1 thiab COX-2) thiab kev tsis tuaj yeem txwv tsis pub lub cyclooxygenase txoj kev ntawm arachidonic acid metabolism, thaiv qhov synthesis ntawm PG (PGA)₂PGD₂, PGF_2alphaPGE₁PGE₂ thiab lwm tus) thiab thromboxane. Txo hyperemia, exudation, capillary permeability, hyaluronidase kev ua haujlwm, txwv lub zog muab hluav taws xob ntawm cov txheej txheem inflammatory los ntawm inhibiting ATP ntau lawm. Cuam tshuam subcortical cov chaw ntawm thermoregulation thiab hnov mob mob. GHG txo qis (feem ntau yog PGE₁ ) nyob rau hauv qhov chaw nruab nrab ntawm cov thermoregulation ua rau txo qis hauv lub cev kub vim tias nthuav txav ntawm cov hlab ntsha ntawm daim tawv nqaij thiab nce tawm hws. Qhov kev ua kom loog no yog vim muaj txiaj ntsig rau qhov chaw ntawm qhov mob ntawm qhov mob, nrog rau peripheral anti-inflammatory kev txiav txim siab thiab muaj peev xwm ntawm salicylates los txo cov algogenic nyhuv ntawm bradykinin. Thromboxane Qhov txo qis₂ hauv platelets ua rau kev tsis tuaj yeem tsis pom kev ntawm kev sib cais, ib nyuag dilates cov hlab ntsha. Cov nyhuv antiplatelet muaj txuas ntxiv mus li 7 hnub tom qab siv ib zaug. Ib tug xov tooj ntawm cov kev tshawb fawb soj ntsuam tau pom tias qhov tseem ceeb inhibition ntawm adhesion ntawm ntshav cov ntshav tau tiav ntawm koob tshuaj txog 30 mg. Kev ua ntshav plasma fibrinolytic ntau dua thiab txo qis cov ntsiab lus ntawm vitamin K-dependant coagulation yam (II, VII, IX, X). Nws stimulates qhov tsis pom ntawm uric acid, txij li nws txoj kev thim rov qab rau hauv lub raum plab yog qhov tsis taus.

Tom qab lub qhov ncauj tswj hwm, nws txaus. Nyob rau hauv muaj qhov ncauj nkag (tiv taus cov kev ua ntawm lub plab kua txiv thiab tsis tso cai rau kev nqus ntawm acetylsalicylic acid hauv lub plab), nws yog nqus nyob rau sab qaum kev ntawm txoj hnyuv. Thaum lub sij hawm nqus, nws hla tawm lub cev presystemic kev tshem tawm hauv lub plab hnyuv phab ntsa thiab hauv daim siab (deacetylated). Qhov nqus ib feem yog hydrolyzed sai heev los ntawm tshwj xeeb esterases, yog li ntawd, T_1/2 acetylsalicylic acid tsis ntau tshaj 15-20 feeb. Nws circulates hauv lub cev (75-90% vim yog albumin) thiab muab faib rau hauv cov ntaub so ntswg ua anion ntawm salicylic acid. C_max ua tiav tom qab kwv yees li 2 teev. Acetylsalicylic acid kev ua haujlwm tsis khi rau cov ntshav protein. Thaum lub sij hawm biotransformation, metabolites yog tsim nyob rau hauv daim siab uas pom muaj nyob rau hauv ntau cov ntaub so ntswg thiab zis. Kev nthuav tawm ntawm salicylates yog nqa tawm tshwj xeeb los ntawm kev ua kom zoo nyob rau hauv cov tubules ntawm lub raum hauv daim ntawv tsis hloov pauv thiab hauv daim ntawv ntawm metabolites. Qhov kev tshem tawm ntawm cov tshuaj tsis hloov pauv thiab cov roj ntsha hloov pauv nyob ntawm lub pH ntawm cov zis (nrog rau kev tso zis ntawm cov zis, ionization ntawm salicylates nce, lawv cov kev ua kom rov muaj mob loj dua, thiab qhov kev nthuav tawm nce ntxiv).

Kev siv cov tshuaj Acetylsalicylic acid

IHD, muaj ntau yam kev pheej hmoo rau IHD, tsis hnov mob myocardial ischemia, tsis txaus ntseeg lub siab tsis txaus, myocardial infarction (los txo cov kev pheej hmoo ntawm myocardial infarction thiab kev tuag tom qab myocardial infarction), rov qab hloov kho lub hlwb ischemia thiab ischemic stroke ntawm tus txiv neej, lub plawv mob (kev tiv thaiv thiab kev kho mob ntawm thromboembolism) , lub pob txha caj qaum ua cov hlab ntsha angioplasty thiab tso qhov quav (txo txoj kev pheej hmoo ntawm kev rov mob qog ntshav thiab kev kho mob ntawm cov ntshav khov ntawm txoj hlab ntshav), nrog rau qhov tsis mob ntshav tawm ntawm cov leeg ntshav. ry (Kawasaki kab mob), aortoarteriit (Takayasu kab mob), mitral valve tsis xws luag ntawm lub plawv thiab cov atrial fibrillation, mitral valve prolapse (thromboembolism prophylaxis), recurrent pulmonary embolism, Dressler lub syndrome, pulmonary infarction, mob thrombophlebitis. Ua npaws rau kis tus kab mob thiab kab mob. Mob qhov mob ntawm qhov tsis muaj zog thiab nruab nrab ntawm ntau yam keeb kwm, suav nrog thoracic radicular syndrome, lumbago, migraine, mob taub hau, neuralgia, mob hniav, mob myalgia, mob caj dab, mob algomenorrhea. Hauv kev txhaj tshuaj tiv thaiv kab mob thiab kev ua xua, nws tau siv ntau dua qhov tshuaj ntxiv rau ntev li ntawm "aspirin" desensitization thiab kev tsim cov kev mob siab rau NSAIDs hauv cov neeg mob uas muaj "aspirin" hawb pob thiab "aspirin" triad.

Raws li kev ntsuas, mob rheumatism, rheumatic chorea, mob rheumatoid, mob caj dab-myocarditis, mob pericarditis - tam sim no siv tsis tshua muaj neeg.

Cev xeeb tub thiab lactation

Kev siv cov ntsev loj ntawm salicylates nyob rau thawj peb lub hlis ntawm cev xeeb tub yog cuam tshuam nrog kev nce ntxiv ntawm cov me nyuam hauv plab kev loj hlob tsis zoo (ua rau lub qhov ncauj ntawm lub plab, lub plawv tsis zoo). Hauv lub hlis thib ob ntawm cev xeeb tub, salicylates tuaj yeem tsuas yog coj mus rau hauv kev ntsuas kev soj ntsuam ntawm kev pheej hmoo thiab muaj txiaj ntsig. Kev teem caij ntawm salicylates nyob rau hauv III sijhawm ntawm cev xeeb tub yog contraindicated.

Salicylates thiab lawv cov metabolites hauv cov khoom me me kis mus rau niam mis. Kev noj cov salicylates ntau thaum lub sijhawm lactation tsis yog nrog kev txhim kho cov nyom hauv tus menyuam thiab tsis tas yuav tsum tsis tsum txog kev pub niam mis rau menyuam noj. Txawm li cas los xij, nrog kev siv lub sijhawm ntev lossis kev tswj hwm nyob rau hauv cov koob tshuaj ntau, kev pub niam mis yuav tsum tsis ua ntxiv.

Cov lus qhia rau kev siv Acetylsalicylic acid, ntau npaum li cas

Cov ntsiav tshuaj yog npaj rau kev siv qhov ncauj - nws raug nquahu kom noj tom qab noj mov nrog mis nyuj, ib txwm dej lossis alkaline ntxhia dej.

Kev noj tshuaj ntawm cov tshuaj acetylsalicylic acid raws li cov lus qhia rau kev siv rau cov neeg laus - los ntawm 500 mg rau 1 g (1-2 ntsiav tshuaj) txog 4 zaug hauv ib hnub.

Qhov ntau npaum li cas tsuas tshuaj yog 1 gram (2 ntsiav tshuaj).
Qhov tshuaj ntau ntau txhua hnub yog 3 grams (6 ntsiav tshuaj)

Txhawm rau txhim kho rheological zog ntawm cov ntshav, nrog rau cov tshuaj tiv thaiv ntawm platelet adhesion, ib nrab ib ntsiav tshuaj ntawm acetylsalicylic acid ib hnub yog tshuaj rau ob peb lub hlis.

Nrog myocardial infarction thiab rau kev tiv thaiv ntawm theem nrab myocardial infarction, nws raug nquahu kom noj 250 mg ib hnub twg.

Kev cuam tshuam hauv lub cev tsis sib xws hauv lub hlwb thiab lub hlwb thombo thromboembolism pom zoo kom noj ib nrab ntsiav tshuaj nrog kev kho me ntsis ntawm cov koob tshuaj rau 2 ntsiav tshuaj ntawm Acetylsalicylic acid ib hnub.

Sab sij huam

Cov kev qhia ceeb toom txog kev muaj peev xwm tsim cov kev mob tshwm sim hauv qab no thaum sau ntawv Acetylsalicylic acid:

mob mob epigastric, xeev siab, ntuav,
zawv plab
kiv taub hau thiab qaug zog
tsis qab los noj mov
kev pom,
los ntshav - plab hnyuv, ntswg, gingival, pais plab,
hloov pauv hauv cov duab hauv chaw kuaj ntshav - txo qis cov ntshav hemoglobin thiab platelets,
mob hauv lub siab thiab lub raum,
kev txhim kho mob raum tsis zoo,
bronchospasm, hauv cov xwm txheej loj, kev txhim kho ntawm kev mob hlwb thiab anaphylactic poob siab.

Cov Yuav Tsum Muaj

Acetylsalicylic acid yog sib kis hauv cov xwm txheej hauv qab no:

mob hnyuv los ntshav,
tshuaj aspirin triad,
exacerbation ntawm erosive thiab ulcerative txhab ntawm lub plab zom mov,
kev siv tshuaj tiv thaiv kev siv cov tshuaj acetylsalicylic acid thiab lwm yam tshuaj los tiv thaiv kev tiv thaiv ntawm kev ua mob ntawm urticaria thiab rhinitis,
hemorrhagic diathesis,
hemophilia
hypoprothrombinemia,
portal tawg
kub siab, kev pheej hmoo ntawm cov ntshav hemorrhagic,
stratified aortic aneurysm,
piam thaj-6-phosphate dehydrogenase tsis txaus,
Vitamin K tsis txaus
lub raum thiab lub siab ua haujlwm,
Reye's syndrome.

Tsis tas li, cov tshuaj yog contraindicated rau hauv cov poj niam cev xeeb tub, thaum lactation thiab nrog muaj zog rhiab heev rau cov khoom siv.

Acetylsalicylic acid tsis yog siv los kho cov menyuam yaus thiab cov hluas uas muaj mob lossis rov zoo los ntawm tus mob qhua taum thiab mob ua npaws, vim tias kev txhim kho ntawm kev mob hepatic encephalopathy ua tau.

Noj ntau dhau

Kev noj tshuaj ntau tshaj ntawm acetisalicylic acid yog nrog los ntawm kev ua haujlwm tsis zoo acid-puag thiab electrolyte tshuav nyiaj li cas. Xeev siab, ntuav, mob nyob rau hauv thaj chaw epigastric, tsis hnov lus thiab pom tseeb tseeb tau sau tseg.

Kev xav tsis meej, tsis meej pem, tshee hnyo, tsaug zog, lub cev qhuav dej, ib qho tshuaj tiv thaiv alkaline, tsis nco qab, metabolic acidosis, thiab ua txhaum kev cuam tshuam ntawm carbohydrate metabolism kuj tseem muaj peev xwm ua tau.

Kev kho mob yog raws kev ua kom nrawm nrawm ntawm kev tshem tawm cov tshuaj, nrog rau kev ua kom zoo li qub ntawm acid-base tshuav nyiaj.

Cov tshuaj Acetylsalicylic acid, tus nqi hauv cov chaw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Acetylsalicylic acid nrog ib qho analogue ntawm cov tshuaj nquag - cov no yog cov tshuaj:

Thaum xaiv cov tshuaj analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv acetylsalicylic acid, tus nqi thiab tshuaj xyuas cov tshuaj uas muaj cov txiaj ntsig zoo sib xws tsis siv. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Nqe hauv khw muag tshuaj Lavxias: ntsiav tshuaj Acetylsalicylic acid 500mg 10pcs. - los ntawm 4 txog 9 rubles, 20 ntsiav tshuaj - los ntawm 15 txog 21 rubles, raws li 592 cov chaw muag tshuaj.

Txav mus cuag cov menyuam yaus ntawm qhov ntsuas kub tsis tshaj + 25 ° C. Txee lub neej yog 4 xyoos. Muag hauv chaw muag tshuaj yam tsis muaj daim ntawv yuav tshuaj.