Yuav siv li cas Lorista N rau mob ntshav qab zib > Kev khomob thiab kev tiv thaiv

Lorista ® N - cov tshuaj sib txuam, muaj kev cuam tshuam hypotensive.

Losartan. Xaiv cov angiotensin II receptor antagonist (hom AT 1) rau kev tswj hwm qhov ncauj, qhov tsis muaj protein ntau. Hauv vivo thiab hauv vitro losartan thiab nws qhov kev ua haujlwm lom neeg lub cev carboxy metabolite (EXP-3174) thaiv tag nrho cov kev mob ntawm lub cev mob siab ntawm angiotensin II ntawm AT 1 receptors.

Losartan tsis ncaj qha ua rau kev ua kom ntawm AT 2 receptors los ntawm kev nce qib ntawm angiotensin II.

Losartan tsis inhibit qhov kev ua ntawm kininase II, yog ib qho enzyme uas koom nrog hauv cov metabolism hauv ntawm bradykinin.

Nws txo OPSS, siab hauv "me" ntawm lub voj voog ntawm cov ntshav ncig, txo qis tom qab, muaj cov nyhuv diuretic.

Nws cuam tshuam nrog kev txhim kho myocardial hypertrophy, ua rau lub cev muaj zog ntau dua nyob rau hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev. Kev noj cov tshuaj losartan ib hnub ib zaug ua rau muaj kev txo nqi ntawm cov ntaub ntawv tseem ceeb hauv SBP thiab DBP. Losartan tusyees tswj lub siab thoob plaws ib hnub, thaum cov nyhuv antihypertensive sib raug rau lub ntuj circadian atherosclerosis. Qhov kev txo qis hauv cov ntshav siab thaum kawg ntawm qhov kawg ntawm cov tshuaj yog kwv yees li 70-80% ntawm cov nyhuv ntawm qhov kawg ntawm cov tshuaj, 5-6 teev tom qab kev tswj hwm. Ntsoos ntsoos mob los tsis pom, thiab losartan tsis muaj kev cuam tshuam loj ntawm lub plawv dhia.

Losartan muaj txiaj ntsig zoo rau tus txiv neej thiab poj niam, nrog rau cov laus (laus dua 65 xyoos) thiab cov neeg mob yau (hnub nyoog qis dua 65 xyoos).

Hydrochlorothiazide. Ib qho thiazide diuretic, uas nws cov nyhuv diuretic yog cuam tshuam nrog kev ua txhaum ntawm kev rov ua kom rov qab los ntawm sodium, chlorine, potassium, magnesium, dej ions nyob rau hauv lub distal nephron, qeeb kev nthuav tawm ntawm calcium ions, uric acid. Nws muaj cov khoom antihypertensive. Zoo tsis muaj kev cuam tshuam dab tsi rau ntshav siab.

Cov nyhuv diuretic tshwm sim tom qab 1-2 teev, nce mus txog qhov siab kawg tom qab 4 teev thiab kav ntev li 6-12 teev. Cov nyhuv antihypertensive tshwm sim tom qab 3-4 hnub, tab sis nws yuav siv sijhawm 3-4 lub lis piam kom ua tiav cov nyhuv kho tau zoo.

Cov Tshuaj Pharmacokinetics

Lub chaw muag tshuaj ntawm losartan thiab hydrochlorothiazide thaum noj tib txhij tsis txawv li ntawd thaum muab cais ua ke.

Losartan. Nws yog zoo nqus los ntawm cov hnyuv. Nws muaj cov metabolism hauv lub cev tseem ceeb thaum "thawj kev tso cai" los ntawm daim siab, ua rau lub cev muaj cov metabolite (EXP-3174) nrog cov carboxylic acid thiab lwm cov kev siv lub cev tsis muaj zog. Bioavailability yog kwv yees li 33%. Noj tshuaj nrog zaub mov noj tsis muaj kev cuam tshuam loj hauv nws txoj kev kuaj ntshav. T max - 1 teev tom qab kev tswj hwm ntawm qhov ncauj, thiab nws cov tshuaj tiv thaiv metabolite (EXP-3174) - 3-4 teev.

Ntau tshaj li 99% ntawm losartan thiab EXP-3174 khi rau cov ntshav muaj protein ntau, feem ntau yog nrog albumin. Qhov ntim ntawm kev faib tawm ntawm losartan yog 34 litres. Nws nkag mus ntau heev los ntawm BBB.

Losartan yog cov tshuaj tiv thaiv nrog kev tsim cov tshuaj ua kom nquag plias (EXP-3174) metabolite (14%) thiab cov neeg tsis muaj zog, suav nrog 2 cov metabolites loj tsim los ntawm hydroxylation ntawm pab pawg butyl ntawm cov saw, thiab muaj qhov tsis tshua muaj metabolite - N-2-tetrazole glucuronide.

Lub plasma tshem ntawm losartan thiab nws cov metabolite yog kwv yees li 10 ml / s (600 ml / min) thiab 0.83 ml / s (50 ml / min), feem. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite nquag yog li 1.23 ml / s (74 ml / min) thiab 0.43 ml / s (26 ml / min). T 1/2 ntawm losartan thiab cov metabolite nquag muaj 2 teev thiab 6-9 teev, ua ntu zus. Nws yog feem ntau tsuas yog nrog cov kua tsib - 58%, raum - 35%.

Hydrochlorothiazide. Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus ntawm hydrochlorothiazide yog 60-80%. C max hydrochlorothiazide nyob rau hauv cov ntshav tau tiav 1-5 teev tom qab noj.

Kev khi rau cov ntshav protein ntawm hydrochlorothiazide yog 64%.

Hydrochlorothiazide tsis yog metabolized thiab raug tawm sai sai los ntawm lub raum. T 1/2 yog 5-15 teev.

Cov mob tshwj xeeb

1 tab losartan poov tshuaj 100 mg hydrochlorothiazide 25 mg Cov Qhua: pregelatinized hmoov txhuv nplej siab - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Cov tshuaj sib xyaw ua ke ntawm cov zaj duab xis membrane: hypromellose - 10 mg, macrogol 4000 - 1 mg, zas quinoline daj (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan poov tshuaj 100 mg hydrochlorothiazide 12.5 mg Cov Cim: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc. losartan potassium 100 mg hydrochlorothiazide 25 mg Cov Qhua: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Cov Cim: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate Plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), tal. losartan poov tshuaj 50 mg hydrochlorothiazide 12.5 mg Cov tsis muaj zog: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc.

Lorista N contraindications

Cov tshuaj tiv thaiv kab mob rau losartan, rau cov tshuaj tau los ntawm sulfonamides thiab lwm yam tshuaj, anuria, mob tsis zoo rau lub raum (creatinine tshem tawm (CC) tsawg dua 30 ml / min.), Hyperkalemia, lub cev qhuav dej (nrog rau cov koob tshuaj diuretics zoo) mob siab rau lub siab tsis ua haujlwm, mob refractory hypokalemia, cev xeeb tub, lactation, hlab ntsha hypotension, hnub nyoog qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim), lactase deficiency, galactosemia lossis glucose / gal malabsorption syndrome Kev cai. Nrog ceev faj: dej-electrolyte ntshav tshuav kev puas tsuaj cuam tshuam (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), ob leeg lub raum artery stenosis lossis mob ntshav qab zib ntawm ib lub raum artery, ntshav qab zib mellitus, hypercalcemia, hyperuricemia thiab / lossis gout, mob siab rau qee qhov kev tsis haum ntshav ntawm lub raum. tsim ua ntej nrog lwm cov tshuaj, suav nrog AP inhibitors

Lorista N phiv

Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: ua haujlwm yam tsis muaj tseeb: ntshav liab, Shenlane-Genokha purpura. Ntawm kev tiv thaiv kab mob hauv lub cev: tsis tshua muaj: kev xav ua kom tsis haum, mob hlwb (suav nrog o ntawm lub ntsej muag thiab tus nplaig, ua rau ob leeg txoj hlab pas thiab / lossis o ntawm lub ntsej muag, daim di ncauj, pharynx). Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb peripheral: feem ntau: mob taub hau, lub cev thiab tsis muaj zog kiv taub hau, pw tsaug zog, qaug zog, tshwm sim: mob taub hau. Los ntawm cov hlab plawv system: feem ntau: orthostatic hypotension (koob tshuaj-siv tshuaj), palpitations, tachycardia, tsis tshua muaj: vasculitis. Los ntawm cov kab mob ua pa: feem ntau: hnoos, mob ntsws sab sauv, pharyngitis, o ntawm lub qhov ntswg mob. Los ntawm kev mob plab hnyuv: feem ntau: raws plab, dyspepsia, xeev siab, ntuav, mob plab. Los ntawm kab mob hepatobiliary: tsis tshua muaj: kab mob siab, ua kom lub siab ua haujlwm. Los ntawm daim tawv nqaij thiab cov rog rog subcutaneous: ncaw: urticaria, tawv nqaij khaus. Los ntawm cov leeg musculoskeletal thiab cov nqaij sib txuas: feem ntau: myalgia, rov qab mob, tshwm sim: mob pob txha. Lwm yam: feem ntau: asthenia, tsis muaj zog, peripheral edema, mob hauv siab. Qhov ntsuas pom: feem ntau: hyperkalemia, nce concentration ntawm hemoglobin thiab hematocrit (tsis yog qhov tseem ceeb hauv kev kho mob), ua tsis xws luag: muaj kev nce qib hauv cov ntshav urea thiab creatinine, tsis tshua muaj: kev ua si ntawm daim siab thiab bilirubin enzymes.

Cia rau cov neeg mob

khw nyob rau ntawm chav tsev kub txog 15-25 degrees
txav deb ntawm menyuam yaus

Cov ntaub ntawv muab

Txhua xyoo, ntau thiab ntau tus neeg txom nyem los ntawm kev txhim kho cov kab mob plawv. Raws li kev txheeb cais, tsis ntev los no, txawm tias cov menyuam yaus me tau ntsib qhov teeb meem no. Niaj hnub no, muaj ntau cov tshuaj uas pab tua tawm tsam kub siab. Ib qho zoo tshaj plaws yog Lorista N

Lorista N yog cov tshuaj sib txuam uas muaj qhov ua kom hypotensive. Cov tshuaj hauv nws cov pes tsawg leeg ua rau cov ntshav siab thiab pab tshem tawm lub plawv nres. Cov txiaj ntsig zoo ntawm cov ntsiav tshuaj yog lav los ntawm lub ntsiab nquag sib xyaw -. Nws provokes inhibition of angiotensin II receptors nyob rau hauv lub plawv, cov hlab ntsha thiab raum. Raws li qhov txiaj ntsig ntawm qhov no, qhov kev txo qis ntawm vasoconstriction yog pom.

Tsis zoo li Lorista

Hauv cov chaw muag tshuaj Lavxias, ntau cov khoom lag luam zoo ib yam muaj muag ib zaug - Lorista N thiab ntau tus tsis paub qhov txawv ntawm lawv yog dab tsi.

Lub ntsiab sib txawv yog nyob rau hauv cov tshuaj ntawm cov tshuaj. Nyob rau hauv Lorista, losartan kuj tseem yog cov tseem ceeb ua ke. Lub luag haujlwm ntawm cov khoom siv ntxiv yog ua los ntawm: pob kws hmoov txhuv nplej siab, cellactose, magnesium stearate.

Hauv kev hloov kho dua tshiab ntawm cov tshuaj no nrog kev ua ntej H, cov npe tau ntxiv los ntawm hydrochlorothiazide. Nws ua rau txo qis hauv qib ntawm cortical ntu ntawm Na + reabsorption. Kuj tseem tsis tas yuav xaiv ib tus zuj zus xaiv kev pib tshuaj rau cov neeg mob hnub nyoog laus.

Lwm qhov sib txawv ntawm cov tshuaj no yog nqi. Tus nqi nruab nrab ntawm Lorista yog me ntsis qis thiab muaj ntau npaum li 100-130 rubles. Raws li rau lub tshuab ntawm kev txiav txim, ob qho tshuaj ទាំងពីរ pab txo qis ntshav siab.

Daim ntawv thiab kwv yees tus nqi ntawm cov tshuaj

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj uas muaj lub zas daj. Qee lub sij hawm muaj ntsiav tshuaj ntawm cov xim ntsuab. Lawv yog qhov me me hauv qhov loj me thiab oval hauv cov duab, uas ua rau txais tos yooj yim dua li sai tau. Ntawm ib sab muaj qhov kab sib cais (Lorista ND, muaj cov ntsiab lus siab ntawm cov nquag nquag, nws tsis tuaj).

Tom qab dhau qhov kev kuaj mob thiab sab laj tus kws tshaj lij, tus neeg mob tuaj yeem nkag siab qhov twg yog qhov zoo dua hauv nws kis tshwj xeeb - N lossis ND. Nws tsis tsim nyog nws los kho kev kho mob rau koj tus kheej, kom tsis txhob ua mob rau lub cev. Tus nqi nruab nrab yog 230 rubles.

Daim Ntawv	Nqe, tshiav.
50 +12.5 mg, No. 90	Los ntawm 627
50 +12.5 mg, 60	Los ntawm 510
50 +12.5 mg, 30	Los ntawm 287
100 +12.5 mg No. 90	Los ntawm 785

Kev Sau ua ke, kev siv tes ua ntawm kev coj ua thiab cov khoom

Txhua lub ntsiav tshuaj yog zaj duab xis-txheej thiab muaj: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), pregelatinized pob kws hmoov nplej, MCC, magnesium stearate thiab lactose monohydrate. Kuj, ntsiav tshuaj muaj nyob nrog cov ntsiab lus nce ntawm losartan (100 mg). Lawv hu ua Lorista ND. 25 mg ntawm hydrochlorodisiad tau ntxiv rau lawv muaj pes tsawg leeg. Ntu ntu puav leej muaj qhov qub.

Txog rau kev tsim cov yeeb yaj kiab txheej, cov tuam ntxhab siv talc, daj zas, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Tus txheej txheem ntawm kev ua haujlwm ntawm cov kev ua haujlwm nquag yog txhawm rau txo ntshav siab thiab txo qis tom qab lub siab. Cov cheebtsam ntawm cov ntsiav tshuaj ua rau muaj kev nce ntxiv ntawm plasma renin kev ua haujlwm, txo qis hauv cov ntsiab lus poov tshuaj potassium thiab kev txhim kho aldosterone secretion.

Cov tshuaj tseem ceeb ntawm cov tshuaj yog cim los ntawm kev ua uricosuric. Nws nplov lub cev kev mob ntawm angiotensin II. Ua ke nrog hydrochlorothiazide, cov tshuaj cuam tshuam txo hyperuricemia. Cov tshuaj tsis cuam tshuam rau zaus ntawm kev mob plab ntawm lub siab nqaij pob txha. Antihypertensive nyhuv yog nqa tawm los ntawm kev nthuav dav ntawm cov hlab ntsha. Tom qab 2-3 teev, cov nyhuv tshwm sim uas kav rau ib hnub.

Losartan tau zoo haum rau ntawm txoj hnyuv, qhov ua kom siab zoo ntawm bioavailability yog 32-33%. Qhov khi ua ke rau cov ntshav protein. Kwv yees li ntawm 58% ntawm cov tshuaj tau tawm hauv lub cev nrog cov kua tsib, thiab 35% yog txia tawm los ntawm lub raum. Tom qab noj, hydrochlorothiazide los rau hauv kev sib cuag nrog cov plasma protein (kwv yees li 65%). Hauv 5-10 teev tawm ntawm lub cev nrog zis.

Kev taw qhia thiab kev txwv

Cov tshuaj ua yeeb yam yog ib qho ntawm cov khoom siv ntawm kev kho mob nyuaj hauv kev txheeb xyuas ntawm txoj kev mob ntshav siab. Kuj tseem yuav muaj xws li:

Txo txoj kev pheej hmoo ntawm kev tsim mob vascular thiab mob plawv.
Kev tshem tawm ntawm cov tsos mob tsis zoo nrog sab laug ventricular hypertrophy.

Sab laug ventricular hypertrophy

Lorista N muaj tus naj npawb ntawm cov contraindications, uas yuav tsum tau them nyiaj tshwj xeeb ua ntej noj:

lub cev qhuav dej
tsis muaj lactose hauv lub cev,
anusia
lub raum tsis ua hauj lwm
ntshav siab
cev xeeb tub
tus kheej intolerance los yog hypersensitivity rau lub Cheebtsam.

Tsis tas li, cov tshuaj tsis tau sau tseg rau cov menyuam yaus hnub nyoog qis dua 18 xyoo. Nrog gout, ntshav qab zib, mob hawb pob, kab mob ntshav, cov tshuaj tau tso cai, tab sis nyob rau hauv kev tswj hwm nruj ntawm cov kws kho mob koom.

Kev muab tshuaj rau tus kheej tuaj yeem ua rau qhov teeb meem txaus ntshai ntxiv. Ua ntej noj cov tshuaj, koj yuav tsum paub txog yam dab tsi siab nws yog kws kho mob.

Cov lus qhia rau kev siv

Cov tshuaj yog npaj rau cov thawj coj hauv qhov ncauj, tsis hais txog ntawm cov khoom noj. Tso tshuaj sib txuam nrog cov tshuaj rau txo cov ntshav siab yog tso cai. Dosage nyob ntawm hom ntawm pathology.

Raws li cov lus qhia rau kev siv, nrog mob ntshav ntawm txoj hlab ntshav tauj ib hnub, nws raug tso cai kom noj 1 lub tshuaj. Qhov siab tshaj plaws ntau yog 2 pcs. Tus xav tau koob tshuaj nce siab yog txiav txim los ntawm tus kws khomob.

Thaum kuaj mob sab laug ventricular hypertrophy, qhov pib siv tshuaj rau txhua hnub kuj yog 50 mg, uas yog, 1 ntsiav tshuaj. Thaum sawv ntxov lossis yav tsaus ntuj - nws tsis tshua muaj xwm txheej.

Cov neeg mob xav tau tshuaj yog tias haus cov tshuaj rau lub neej los yog tsis noj. Txhawm rau kom qhov siab ceev rov qab thiab cov tsos mob ntawm tus kab mob mus rov qab, nws yog qhov yuav tsum tau ua kom tiav qhov kev kawm tag nrho (kwv yees li 30 hnub). Tom qab ntawd, tus kws kho mob uas koom nrog yuav ua lwm qhov kev tshuaj xyuas thiab tshaj tawm cov haujlwm ntxiv. Nrog kev rov ua phem, koj yuav tsum tau kawm dua.

Nws yog ib qho tseem ceeb uas yuav tsum xav txog kev sib cuam tshuam ntawm cov tshuaj:

Phiv thiab haus tshaj

Yog hais tias cov tshuaj no noj tsis tsim nyog, qhov tsis xav pom yuav tshwm sim (Cov Lus 2).

Tsis tas li, cov kev mob tshwm sim tuaj yeem tshwm sim rau hauv daim ntawv ntawm kev ua xua ntawm daim tawv nqaij, uas nrog nrog khaus. Yog hais tias noj ntau dhau, tus neeg mob muaj:

kev sib tw ntawm bradycardia / tachycardia,
tus nqi txo cov ntshav siab heev,
kev npau suav,
tshuaj tiv thaiv hypochloremia.

Yog tias thawj cov cim ntawm kev txhaj tshuaj ntau dhau hwv lawm, nws yuav tsum tau sab laj nrog tus kws kho mob tshwj xeeb. Cov kev pabcuam thawj zaug hauv cov kis no yog kev mob plab. Ntxiv mus, tus neeg mob yuav tsum tau muaj kev kho tsos mob.

Rau kev kho mob ntawm cov hlab plawv pathologies, nrog rau cov ntshav siab ntau dua, Lorista N. hloov chaw kuj tseem siv. Feem ntau, qhov kev xav tau no tshwm sim rau kev sib txuas nrog tus tib neeg kev tsis txaus ntseeg ntawm qee yam.

Tsis tas li ntawd, qee qhov analogues yog qhov pheej yig dua Lorista N. Cov npe tshuaj uas muaj ib qho zoo sib xws ntawm kev ua muaj xws li:

Co-Centor (50 mg). Tus nqi yog 130 rubles.
(Zaj 30). Cov tshuaj yuav tuaj yeem yuav rau 100-110 rubles.
Lozap 100 Ntxiv (250 rubles).
Simartan-N.

Ua ntej hloov cov tshuaj uas kws kho mob tau sau tseg, nws yog qhov yuav tsum tau sab laj nrog nws, yog li kom tsis txhob cuam tshuam qhov tshwm sim ntawm cov teeb meem.

Cov lus sib xyaw thiab daim ntawv ntawm cov tshuaj

Zaj duab xis-coated ntsiav tshuaj los ntawm daj mus rau daj nrog lub pob ntsuab greenish, zes, me ntsis biconvex, nrog kev pheej hmoo ntawm ib sab, hom ntsiav tshuaj hauv ntu ntu yog qhov tseem ceeb ntawm cov ntsiav tshuaj dawb.

Cov muaj mob: cov hmoov txhuv nplej siab pregelatinized - 34.92 mg, microcrystalline cellulose - 87,7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Muaj pes tsawg leeg zaj duab xis plhaub: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, zas quinoline daj (E104) - 0.11 mg, titanium dioxide (E171) - 1,39 mg, talc - 0.5 mg.

10 Pcs. - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (6) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (9) - pob khoom los ntawm cardboard.

Pharmacological kev txiav txim

Pharmacological kev txiav txim - hypotensive .

Cov Tshuaj Hauv Tshuaj

Lorista ® N - cov tshuaj sib txuam, muaj kev cuam tshuam hypotensive.

Losartan tsis ncaj qha ua rau kev ua kom ntawm AT 2 receptors los ntawm kev nce qib ntawm angiotensin II.

Losartan tsis inhibit qhov kev ua ntawm kininase II, yog ib qho enzyme uas koom nrog hauv cov metabolism hauv ntawm bradykinin.

Nws txo OPSS, siab hauv "me" ntawm lub voj voog ntawm cov ntshav ncig, txo qis tom qab, muaj cov nyhuv diuretic.

Losartan muaj txiaj ntsig zoo rau tus txiv neej thiab poj niam, nrog rau cov laus (laus dua 65 xyoos) thiab cov neeg mob yau (hnub nyoog qis dua 65 xyoos).

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv tsis haum rau losartan, rau cov khoom lag luam tau los ntawm sulfonamides thiab lwm yam tshuaj, anuria, mob raum tsis zoo (Cl creatinine 65 xyoo) thiab cov neeg mob yau (

Cov Tshuaj Pharmacokinetics

Cov mob tshwj xeeb

1 tab losartan poov tshuaj 100 mg hydrochlorothiazide 25 mg Cov Qhua: pregelatinized hmoov txhuv nplej siab - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Cov tshuaj sib xyaw ua ke ntawm cov zaj duab xis membrane: hypromellose - 10 mg, macrogol 4000 - 1 mg, zas quinoline daj (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan poov tshuaj 100 mg hydrochlorothiazide 12.5 mg Cov Cim: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc. losartan potassium 100 mg hydrochlorothiazide 25 mg Cov Qhua: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Cov Cim: pregelatinized hmoov txhuv nplej siab, microcrystalline cellulose, lactose monohydrate, magnesium stearate Plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), tal. losartan poov tshuaj 50 mg hydrochlorothiazide 12.5 mg Cov tsis muaj zog: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 4000, quinoline daj zas xim (E104), titanium dioxide (E171), talc.

Lorista N Qhia Txog

* Arterial hypertension (rau cov neeg mob uas pom tias kev sib xyaw ua ke). * Txo txoj kev pheej hmoo mob hlab ntsha hauv lub siab thiab kev tuag ntawm cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy.

Lorista N contraindications

Cov tshuaj tiv thaiv kab mob rau losartan, rau cov tshuaj tau los ntawm sulfonamides thiab lwm yam tshuaj, anuria, mob tsis zoo rau lub raum (creatinine tshem tawm (CC) tsawg dua 30 ml / min.), Hyperkalemia, lub cev qhuav dej (nrog rau cov koob tshuaj diuretics zoo) mob siab rau lub siab tsis ua haujlwm, mob refractory hypokalemia, cev xeeb tub, lactation, hlab ntsha hypotension, hnub nyoog qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim), lactase deficiency, galactosemia lossis glucose / gal malabsorption syndrome Kev cai. Nrog ceev faj: dej-electrolyte ntshav tshuav kev puas tsuaj cuam tshuam (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), ob leeg lub raum artery stenosis lossis mob ntshav qab zib ntawm ib lub raum artery, ntshav qab zib mellitus, hypercalcemia, hyperuricemia thiab / lossis gout, mob siab rau qee qhov kev tsis haum ntshav ntawm lub raum. tsim ua ntej nrog lwm cov tshuaj, suav nrog AP inhibitors

Lorista H dosage

100 mg + 25 mg 12.5 mg + 100 mg 12.5 mg + 50 mg 25 mg + 100 mg 25 mg + 100 mg 50 mg + 12.5 mg

Lorista N phiv

Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: ua haujlwm yam tsis muaj tseeb: ntshav liab, Shenlane-Genokha purpura. Ntawm kev tiv thaiv kab mob hauv lub cev: tsis tshua muaj: kev xav ua kom tsis haum, mob hlwb (suav nrog o ntawm lub ntsej muag thiab tus nplaig, ua rau ob leeg txoj hlab pas thiab / lossis o ntawm lub ntsej muag, daim di ncauj, pharynx). Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb peripheral: feem ntau: mob taub hau, lub cev thiab tsis muaj zog kiv taub hau, pw tsaug zog, qaug zog, tshwm sim: mob taub hau. Los ntawm cov hlab plawv system: feem ntau: orthostatic hypotension (koob tshuaj-siv tshuaj), palpitations, tachycardia, tsis tshua muaj: vasculitis. Los ntawm cov kab mob ua pa: feem ntau: hnoos, mob ntsws sab sauv, pharyngitis, o ntawm lub qhov ntswg mob. Los ntawm kev mob plab hnyuv: feem ntau: raws plab, dyspepsia, xeev siab, ntuav, mob plab. Los ntawm kab mob hepatobiliary: tsis tshua muaj: kab mob siab, ua kom lub siab ua haujlwm. Los ntawm daim tawv nqaij thiab cov rog rog subcutaneous: ncaw: urticaria, tawv nqaij khaus. Los ntawm cov leeg musculoskeletal thiab cov nqaij sib txuas: feem ntau: myalgia, rov qab mob, tshwm sim: mob pob txha. Lwm yam: feem ntau: asthenia, tsis muaj zog, peripheral edema, mob hauv siab. Qhov ntsuas pom: feem ntau: hyperkalemia, nce concentration ntawm hemoglobin thiab hematocrit (tsis yog qhov tseem ceeb hauv kev kho mob), ua tsis xws luag: muaj kev nce qib hauv cov ntshav urea thiab creatinine, tsis tshua muaj: kev ua si ntawm daim siab thiab bilirubin enzymes.

Yeeb tshuaj sib cuam tshuam

Noj ntau dhau

Cia rau cov neeg mob

khw nyob rau ntawm chav tsev kub txog 15-25 degrees
txav deb ntawm menyuam yaus

Cov ntaub ntawv muab

Tsis zoo li Lorista

Hauv cov chaw muag tshuaj Lavxias, ntau cov khoom lag luam zoo ib yam muaj muag ib zaug - Lorista N thiab ntau tus tsis paub qhov txawv ntawm lawv yog dab tsi.

Daim ntawv thiab kwv yees tus nqi ntawm cov tshuaj

Daim Ntawv	Nqe, tshiav.
50 +12.5 mg, No. 90	Los ntawm 627
50 +12.5 mg, 60	Los ntawm 510
50 +12.5 mg, 30	Los ntawm 287
100 +12.5 mg No. 90	Los ntawm 785

Kev Sau ua ke, kev siv tes ua ntawm kev coj ua thiab cov khoom

Txog rau kev tsim cov yeeb yaj kiab txheej, cov tuam ntxhab siv talc, daj zas, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Kev taw qhia thiab kev txwv

Cov tshuaj ua yeeb yam yog ib qho ntawm cov khoom siv ntawm kev kho mob nyuaj hauv kev txheeb xyuas ntawm txoj kev mob ntshav siab. Kuj tseem yuav muaj xws li:

Txo txoj kev pheej hmoo ntawm kev tsim mob vascular thiab mob plawv.
Kev tshem tawm ntawm cov tsos mob tsis zoo nrog sab laug ventricular hypertrophy.

Sab laug ventricular hypertrophy

Lorista N muaj tus naj npawb ntawm cov contraindications, uas yuav tsum tau them nyiaj tshwj xeeb ua ntej noj:

lub cev qhuav dej
tsis muaj lactose hauv lub cev,
anusia
lub raum tsis ua hauj lwm
ntshav siab
cev xeeb tub
tus kheej intolerance los yog hypersensitivity rau lub Cheebtsam.

Kev muab tshuaj rau tus kheej tuaj yeem ua rau qhov teeb meem txaus ntshai ntxiv. Ua ntej noj cov tshuaj, koj yuav tsum paub txog yam dab tsi siab nws yog kws kho mob.

Cov lus qhia rau kev siv

Thaum kuaj mob sab laug ventricular hypertrophy, qhov pib siv tshuaj rau txhua hnub kuj yog 50 mg, uas yog, 1 ntsiav tshuaj. Thaum sawv ntxov lossis yav tsaus ntuj - nws tsis tshua muaj xwm txheej.

Nws yog ib qho tseem ceeb uas yuav tsum xav txog kev sib cuam tshuam ntawm cov tshuaj:

Phiv thiab haus tshaj

Yog hais tias cov tshuaj no noj tsis tsim nyog, qhov tsis xav pom yuav tshwm sim (Cov Lus 2).

Tsis tas li, cov kev mob tshwm sim tuaj yeem tshwm sim rau hauv daim ntawv ntawm kev ua xua ntawm daim tawv nqaij, uas nrog nrog khaus. Yog hais tias noj ntau dhau, tus neeg mob muaj:

kev sib tw ntawm bradycardia / tachycardia,
tus nqi txo cov ntshav siab heev,
kev npau suav,
tshuaj tiv thaiv hypochloremia.

Tsis tas li ntawd, qee qhov analogues yog qhov pheej yig dua Lorista N. Cov npe tshuaj uas muaj ib qho zoo sib xws ntawm kev ua muaj xws li:

Co-Centor (50 mg). Tus nqi yog 130 rubles.
(Zaj 30). Cov tshuaj yuav tuaj yeem yuav rau 100-110 rubles.
Lozap 100 Ntxiv (250 rubles).
Simartan-N.

Ua ntej hloov cov tshuaj uas kws kho mob tau sau tseg, nws yog qhov yuav tsum tau sab laj nrog nws, yog li kom tsis txhob cuam tshuam qhov tshwm sim ntawm cov teeb meem.

Cov lus sib xyaw thiab daim ntawv ntawm cov tshuaj

Cov muaj mob: cov hmoov txhuv nplej siab pregelatinized - 34.92 mg, microcrystalline cellulose - 87,7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Muaj pes tsawg leeg zaj duab xis plhaub: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, zas quinoline daj (E104) - 0.11 mg, titanium dioxide (E171) - 1,39 mg, talc - 0.5 mg.

10 Pcs. - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (6) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (9) - pob khoom los ntawm cardboard.

Pharmacological kev txiav txim

Ua ke nrog tus neeg sawv cev antihypertensive. Losartan thiab hydrochlorothiazide muaj cov nyhuv ntxiv los tiv thaiv kev tiv thaiv, txo cov ntshav siab rau qhov ntau dua li ntawm txhua qhov sib cais.

Losartan yog xaiv cov kev tawm tsam ntawm angiotensin II receptors (hom AT 1) rau kev tswj hwm qhov ncauj. Hauv vivo thiab hauv vitro, losartan thiab nws cov tshuaj pharmacologically nquag metabolite E-3174 thaiv tag nrho cov kev mob tshwm sim ntawm angiotensin II ntawm AT 1 txais, tsis hais txog txoj kev ntawm nws cov synthesis: nws ua rau muaj kev nce siab hauv cov ntshav kev ua si thiab ib qho kev txo qis ntawm aldosterone hauv ntshav ntshav. Losartan tsis ncaj qha ua rau kev ua kom ntawm AT 2 receptors los ntawm kev nce lub siab ntawm cov tshuaj angiotensin II.Nws tsis yog inhibit qhov kev ua ntawm kininase II, ib qho enzyme uas koom nrog hauv cov metabolism hauv ntawm bradykinin. Nws txo OPSS, siab hauv lub ntsws ntsig, txo qis tom qab ntawm lub myocardium, muaj cov nyhuv diuretic. Nws cuam tshuam nrog kev txhim kho myocardial hypertrophy, ua rau lub cev muaj zog ntau dua nyob hauv cov neeg mob uas muaj lub plawv tsis ua hauj lwm ntev (CHF). Noj cov tshuaj losartan 1 zaug / hnub ua rau cov lus pom tseeb txo qis hauv systolic thiab diastolic ntshav siab.

Losartan tusyees tswj ntshav siab thaum nruab hnub, thaum cov nyhuv antihypertensive sib raug rau lub ntuj circadian atherosclerosis. Qhov txo qis hauv ntshav siab thaum kawg ntawm cov koob tshuaj ntawm cov tshuaj kwv yees li 70-80% ntawm cov txiaj ntsig siab tshaj plaws ntawm losartan, 5-6 teev tom qab noj. Yog tsis muaj syndrome ntsoos ntsoos.

Losartan tsis muaj kev cuam tshuam los ntawm kev mob plawv ntawm lub plawv dhia, muaj mob nrab thiab mob ntsws uricosuric zoo.

Hydrochlorothiazide- thiazide diuretic, cov nyhuv diuretic uas cuam tshuam nrog kev ua txhaum ntawm kev rov ua kom rov qab los ntawm sodium, chlorine, potassium, magnesium, dej ions nyob rau hauv lub distal nephron, ncua kev nthuav tawm ntawm calcium ions, uric acid. Nws muaj cov nyhuv antihypertensive, qhov kev txiav txim ntawm uas txhim kho vim yog kev nthuav dav ntawm cov hlab ntsha. Zoo tsis muaj kev cuam tshuam dab tsi rau ntshav siab. Cov nyhuv diuretic tshwm sim tom qab 1-2 teev, nce mus txog qhov siab tshaj plaws tom qab 4 teev thiab kav ntev li 6-12 teev .. Qhov siab tshaj plaws antihypertensive nyhuv tshwm sim tom qab 3-4 hnub, tab sis nws yuav siv sijhawm 3-4 lub lis piam kom ua tiav cov nyhuv kho tau zoo.

Vim yog cov nyhuv diuretic, hydrochlorothiazide ua rau plasma renin kev ua si, txhawb kev tso cai ntawm aldosterone, nce qhov kev tsub zuj zus ntawm angiotensin II thiab txo qhov concentration ntawm poov tshuaj hauv ntshav ntshav. Tau txais losartan thaiv tag nrho cov kev cuam tshuam ntawm lub cev ntawm angiotensin II thiab, vim yog kev tsuj tawm ntawm cov teebmeem ntawm aldosterone, tuaj yeem pab txo kom tsis txhob muaj cov potassium ntxiv nrog rau kev noj tshuaj diuretic. Hydrochlorothiazide ua rau muaj qhov nce me ntsis hauv kev ua haujlwm ntawm uric acid nyob rau hauv cov ntshav, kev sib xyaw ntawm losartan thiab hydrochlorothiazide pab txo qis qhov mob siab ntawm hyperuricemia tshwm sim los ntawm diuretic.

Cov Tshuaj Pharmacokinetics

Lub chaw muag tshuaj ntawm losartan thiab hydrochlorothiazide nrog kev siv txhij tsis sib txawv ntawm qhov lawv siv nrog monotherapy.

Tom qab lub qhov ncauj tswj hwm, losartan yog zoo nqus los ntawm cov hnyuv. Nws muaj cov metabolism hauv tseem ceeb thaum lub sijhawm "thawj hla" los ntawm lub siab, ua rau lub khw muag tshuaj carboxylated metabolite (E-3174) thiab cov metabolites tsis muaj zog. Bioavailability yog kwv yees li 33%. Qhov nruab nrab C max ntawm losartan thiab nws cov metabolite nquag tau mus txog tom qab 1 teev thiab tom qab 3-4 teev, feem. Losartan thiab nws cov nquag metabolite khi rau cov ntshav muaj protein ntau (feem ntau c) los ntawm ntau dua 99%. V d ntawm losartan yog 34 litres. Nws nkag mus ntau heev los ntawm BBB.

Losartan metabolized los ua ib qho kev ua kom nquag plias (E-3174) metabolite (14%) thiab tsis muaj zog, suav nrog ob lub ntsiab metabolites tsim los ntawm hydroxylation ntawm butyl pawg ntawm cov saw thiab cov tsis tshua muaj metabolite, N-2-tetrazolglucuronide. Lub plasma tshem ntawm losartan thiab nws cov metabolite yog kwv yees li 10 ml / sec (600 ml / min) thiab 0.83 ml / sec (50 ml / min), feem. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite nquag yog li 1.23 ml / sec (74 ml / min) thiab 0.43 ml / sec (26 ml / min). T 1/2 ntawm losartan thiab cov metabolite nquag yog 2 teev thiab 6-9 teev, raws li. Nws yog nyob nrog feem ntau nrog cov kua tsib hauv txoj hnyuv - 58%, ob lub raum - 35%. Tsis cumulate.

Thaum noj ntawm qhov ncauj hauv thaj tsam li 200 mg, losartan thiab nws cov tshuaj tiv thaiv metabolite muaj linear pharmacokinetics.

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus ntawm hydrochlorothiazide yog 60-80%. C max hauv cov ntshav ntshav tau tiav 1-5 teev tom qab noj. Kev khi rau cov ntshav plasma protein - 64%. Nkag tau los ntawm thaj chaw siab. Txaus siab nyob rau hauv niam cov mis. Hydrochlorothiazide tsis yog metabolized thiab ua sai tawm los ntawm lub raum. T 1/2 yog 5-15 teev Qhov tsawg kawg 61% ntawm kev noj tshuaj yog coj tsis tau tsis hloov hauv 24 teev.

Arterial hypertension (rau cov neeg mob uas pom tias kev sib xyaw ua ke), txo kev pheej hmoo ntawm cov hlab plawv mob thiab tuag hauv cov neeg mob uas mob ntshav tawm ntawm sab nraud thiab sab laug ventricular hypertrophy.