Protaphane® HM (Protaphane® HM)

Protafan ® HM Penfill ®

Pharmacological kev txiav txim

Nws cuam tshuam nrog ib qho plasma membrane receptor thiab nkag mus rau hauv lub cell, qhov chaw nws ua kom lub phosphorylation ntawm cov xovtooj ntawm cev, ua rau lub cev glycogen synthetase, pyruvate dehydrogenase, hexokinase, inhibits adipose nqaij lipase thiab lipoprotein lipase. Ua ke nrog ib qho tshwj xeeb receptor, nws yooj yim nkag mus ntawm kev nqus ntawm cov kua nplaum mus rau hauv cov hlwb, txhim kho nws txoj kev nkag los ntawm cov ntaub so ntswg thiab txhawb kev hloov dua siab tshiab rau glycogen. Ua rau cov nqaij glycogen ntau ntxiv, txhawb kev ua kom peptide hluavtaws.

Cov Chaw Tshuaj Kho Mob

Cov nyhuv tsim tawm 1.5 teev tom qab kev tswj hwm sc, nce mus txog qhov siab tshaj plaws tom qab 4-12 teev thiab kav ntev li 24 teev. Protafan NM Penfill rau cov tshuaj tiv thaiv kabmob ntshav qab zib mulinitus yog siv los ua cov kab mob basal insulin nyob rau hauv ua ke nrog luv-insulin, rau qhov tsis-insulin-dependant - raws li kev kho mob monotherapy , thiab kev sib xyaw ua ke nrog cov kab hluav taws xob ua haujlwm sai.

Kev sib txuam

Cov nyhuv rau hypoglycemic yog txhim kho los ntawm acetylsalicylic acid, cawv, alpha thiab beta blockers, amphetamine, anabolic steroids, clofibrate, cyclophosphamide, phenfluramine, fluoxetine, ifosfamide, MAO inhibitors, methyldopa, tetracycline, tshwj xeeb trifamazidine, trifamix, trifamix, trifamix thiazides), glucocorticoids, heparin, tshuaj tiv thaiv hormonal, isoniazid, lithium carbonate, nicotinic acid, phenothiazines, sympathomimetics, tricyclic antidepressants.

Tsuas tshuaj thiab tswj hwm

Protafan ® HM Penfill ®

P / c. Cov tshuaj yog npaj rau subcutaneous thawj coj. Kev ncua ntawm insulin tsis tuaj yeem nkag mus rau hauv / hauv.

Cov koob tshuaj ntawm cov tshuaj tau xaiv ib tus zuj zus, ua raws li qhov xav tau ntawm tus neeg mob. Feem ntau, cov tshuaj insulin yog nyob nruab nrab ntawm 0.3 thiab 1 IU / kg / hnub. Kev xav tau cov tshuaj insulin txhua hnub yuav muaj ntau dua rau cov neeg mob insulin tsis kam (piv txwv li, thaum tiav nkauj tiav nraug, thiab cov neeg mob rog rog), thiab qis dua rau cov neeg mob uas muaj cov insulin endogenous ntau lawm.

Protafan ® NM tuaj yeem siv tau ob qho tib si hauv monotherapy thiab muaj kev sib xyaw nrog sai los luv luv ua yeeb yam insulin.

Protafan ® NM feem ntau yog ua rau subcutaneously hauv tus ncej puab. Yog tias qhov no yooj yim, tom qab ntawv hno tuaj yeem ua rau hauv pem hauv ntej lub plab phab ntsa, hauv thaj chaw gluteal lossis hauv deltoid cov leeg ntawm lub xub pwg. Nrog kev qhia txog cov tshuaj rau hauv tus ncej puab, muaj qhov nqus qis dua li thaum qhia mus rau lwm thaj chaw. Yog tias kev txhaj tshuaj yog ua rau cov tawv nqaij txuas ntxiv, qhov kev pheej hmoo ntawm kev siv tshuaj tsis txaus ntseeg ntawm cov tshuaj no tsawg heev.

Lub koob yuav tsum nyob twj ywm hauv qab ntawm daim tawv nqaij tsawg kawg 6 vib nas this, uas tuaj yeem lav ua kom puv koob. Nws yog ib qho tsim nyog los hloov qhov chaw txhaj tshuaj tsis pub dhau thaj chaw anatomical kom tiv thaiv kev txhim kho ntawm lipodystrophy.

Protafan ® NM Penfill ® tsim los siv nrog Novo Nordisk insulin txhaj tshuaj thiab NovoFine ® lossis NovoTvist. Koob. Cov lus qhia ntxaws ntxaws rau kev siv thiab kev tswj hwm ntawm cov tshuaj yuav tsum tau ua kev cai.

Cov kab mob tsis haum, tshwj xeeb yog kis thiab nrog kub taub hau, feem ntau ua rau lub cev xav tau cov tshuaj insulin. Kev hloov kho koob tshuaj kuj tseem xav tau yog tias tus neeg mob tau mob concomitant ntawm lub raum, mob siab, ua tsis taus adrenal, lub caj pas pituitary lossis cov thyroid caj pas. Qhov xav tau kom haum rau kev txhaj tshuaj kuj tuaj yeem tshwm sim thaum hloov lub cev lossis cov neeg mob ib txwm noj. Koob tshuaj yuav tau tuaj yeem hloov kho thaum hloov tus neeg mob los ntawm ib hom tshuaj insulin mus rau lwm tus

Noj ntau dhau

Cov tsos mob kev txhim kho hypoglycemia (tawm hws txias, tawm hws, tshee tshee, tshaib plab, ntxhov siab, chim siab, pallor, mob taub hau, tsaug zog, tsis muaj zog, hais lus thiab pom kev tsis pom kev zoo, kev nyuaj siab). Kev mob ntshav khov ntau heev tuaj yeem ua rau lub hlwb ua haujlwm ib ntus lossis tas mus li, tsis nco qab, thiab tuag.

Kev Kho Mob: qab zib lossis kua qab zib tov sab hauv (yog tias tus neeg mob nco qab zoo), s / c, i / m lossis iv - glucagon lossis iv - qabzib.

Daim ntawv tso tawm

Raug tshem tawm rau kev tswj hwm subcutaneous, 100 IU / ml (vials). Hauv lub khob ntawm cov iav hydrolytic chav kawm 1, corked nrog stoppers los ntawm bromobutyl / polyisoprene roj hmab thiab cov yas hau, 10 ml txhua, hauv ib pob ntawm cov duab los qhia 1 fl.

Ncua rau kev tswj hwm subcutaneous, 100 IU / ml (cartridges). Hauv 3 ml Penfill ® iav daim cartridges, 5 daim cartridges hauv cov hlwv, 1 blister ntim rau hauv ib pob ntawv los qhia.