Chlorhexidine 0.05 Ntshav Qab Zib Tau
Chlorhexidine - ib qho yeeb tshuaj, tshuaj tua kab mob, hauv cov ntawv noj tshuaj tas yog siv cov qauv ntawm bigluconate (Chlorhexidini bigluconas). Chlorhexidine tau ua tiav zoo ua ib qho tshuaj tua kab mob sab nrauv thiab tshuaj tua kab mob rau ntau dua 60 xyoo.
| Chlorhexidine | |
|---|---|
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| Tshuaj lom neeg cov khoom sib txuas | |
| IUPAC | N ',N '`N'v |-hexane-1,6-diylbisN- (4-chlorophenyl) (imidodicarbonimidic diamide) |
| Cov piav suav | C22H30Cl2N10 |
| Molar loj | 505.446 g / mol |
| Cas | 55-56-1 |
| PubChem | 5353524 |
| Tshuajqauj Tshuaj | APRD00545 |
| Kev faib tawm | |
| ATX | A01AB03 B05CA02, D08AC02, D09AA12, R02AA05, S01AX09, S02AA09, S03AA04 |
| Dosage Cov Ntawv | |
| Tus thawj coj kev tswj hwm | |
| Tshuaj pleev lub hauv paus d | |
| Lwm lub npe | |
| “Sebidin”, “Amident”, “Hexicon”, “Chlorhexidine bigluconate” | |
| Cov Ntaub Ntawv Wikimedia Commons Media Files | |
Nws yog tsim nyog sau cia tias rau txhua lub sijhawm ntawm kev coj mus muag thiab kev tshawb fawb science ntawm chlorhexidine, tsis muaj ib qho ntawm lawv tuaj yeem ua pov thawj muaj peev xwm tsim cov chlorhexidine-tiv taus cov kab mob me me. Txawm li cas los xij, raws li kev tshawb fawb tsis ntev los no, kev siv chlorhexidine tuaj yeem ua rau cov tshuaj tua kab mob tiv thaiv kab mob hauv cov kab mob (tshwj xeeb, kev tawm tsam ntawm Klebsiella pneumoniae rau Colistin).
Chemically, nws yog dichloro-muaj derivative ntawm biguanide. Tus qauv yog ze heev rau bigumal. Tus txheej txheem ntawm kev ua ntawm chlorhexidine yog sib cuam tshuam nrog cov pab pawg phosphate nyob rau saum npoo ntawm lub ntsej muag, ua rau muaj kev hloov pauv ntawm osmotic sib npaug, qhov kev ua txhaum ntawm kev ncaj ncees ntawm lub cell thiab nws txoj kev tuag.
Chlorhexidine yog ib qho tshuaj tiv thaiv kab mob uas ua haujlwm tawm tsam gram-positive thiab gram-negative aerobic thiab anaerobic kab mob (Treponema pall>. Cov tshuaj yog qhov ruaj khov thiab tom qab ua cov tawv nqaij (txhais tes, phais thaj chaw, thiab lwm yam) nws tseem nyob ntawm nws hauv qee qhov nyiaj, uas txuas ntxiv muab cov nyhuv bactericidal.
Cov tshuaj tseem muaj nyob rau ntawm cov ntshav, pus, txawm hais tias me ntsis txo. Qee hom ntawm Pseudomonas spp., Proteus spp. Yog cov tsis muaj zog rau chlorhexidine, cov qauv tiv thaiv kua qaub tiv taus kab mob. Chlorhexidine ua haujlwm rau cov kab mob spores tsuas yog ntawm qhov kub nce siab.
Lawv raug siv los kho thaj chaw phais thiab txhais tes ntawm tus kws phais neeg mob, tshem tawm cov twj siv phais, thiab rau cov txheej txheem purulent-septic (ntxuav qhov txhab phais, zais zis, thiab lwm yam) thiab rau kev tiv thaiv kab mob sib kis (mob syphilis, gonorrhea, trichomoniasis). Cov tshuaj ntawm chlorhexidine bigluconate yog muaj li 20% aqueous tov. Npaj siv tshuaj yaj yeeb yog cov kua tshuaj tsis muaj kua tshuaj ntau dua los yog kua tshuaj kua nyeem. Yog li, rau kev ua cov phais phais, ib 20% kev daws yog diluted nrog 70% ethyl cawv nyob rau hauv ib qho kev ntsuas ntawm 1:40. Qhov txiaj ntsig 0.5% aqueous-cawv tso rau kev daws cov chlorhexidine bigluconate yog kho nrog thaj teb phais 2 zaug nrog ntu nruab nrab ntawm 2 feeb. Txhawm rau kom sai sai rau cov twj paj nruag, siv cov tshuaj zoo li 5 feeb. Kev daws teeb meem 0.5% aqueous yog siv rau tshuaj tua kab mob thiab kub hnyiab, cov tshuaj cawv 0,5% dej cawv los yog kua tshuaj 1% aqueous yog siv los ntxuav tshuaj ntxuav tes. Thaum siv cov tshuaj los kho tus neeg phais mob tes, nws yuav ua rau lub cev qhuav thiab khaus ntawm daim tawv nqaij, dermatitis, nplaum ntawm daim tawv nqaij ntawm ob txhais tes li ntawm 3-5 feeb kuj ua tau.
- ib qho kev pom zoo muaj 0.016 g ntawm chlorhexidine bigluconate
Vaginal suppositories (daim ntawv me nyuam mos)
- ib qho tshuaj tiv thaiv muaj 0.008 g ntawm chlorhexidine bigluconate.
- Nkag rau hauv zos thiab sab nraud siv 0.5% (100 g ntawm gel muaj 0.5 g ntawm chlorhexidine bigluconate).
- Ib qho kev daws teeb meem rau kev siv sab nraud ntawm 0.05% (100 ml ntawm cov dej lim muaj ib qho kev daws ntawm chlorhexidine bigluconate 20% - 0.25 ml).
Lub ntsiab rau yaug qhov ncauj kab noj hniav:
- 0.2% aqueous tov
- 0.1% daws ntawm chlorhexidine bigluconate hauv ethanol (Eludryl).
Chlorhexidine ua ib tus neeg sawv cev thiab kho tus mob yog siv tshuaj pleev thiab tshuaj pleev. 0.05%, 0.2% thiab 0.5% aqueous cov kev daws teeb meem yog siv rau hauv cov qauv dej, ua yaug thiab daim ntawv thov - 5-10 ml ntawm cov tshuaj yog thov rau qhov cuam tshuam rau ntawm daim tawv nqaij los yog cov qog ua kua nrog qhov cuam tshuam ntawm 1-3 feeb 2-3 zaug hauv ib hnub (ntawm pob los yog dej los ntawm kev ywg). Kev ua cov cuab yeej siv kho mob thiab thaj chaw ua haujlwm yog nqa nrog daim txhuam cev kom huv nrog cov tshuaj tiv thaiv kab mob, los yog los ntawm soaking. Txog kev tiv thaiv kab mob sib kis los ntawm kev sib daj sib deev, cov tshuaj muaj txiaj ntsig yog tias nws siv tsis pub dhau 2 teev tom qab kev sib deev. Siv lub tog raj, ntxig rau cov ntsiab lus ntawm lub thawb rau hauv qhov zis rau txiv neej (2-3 ml), poj niam (1-2 ml) thiab hauv qhov chaw mos (5-10 ml) rau 2-3 feeb. Kho cov tawv nqaij ntawm qhov chaw sab hauv ntawm tus ncej, pubis, qhov chaw mos. Tom qab cov txheej txheem, tsis tso zis rau 2 teev. Kev kho mob ntawm qhov mob ntawm txoj hlab zis thiab txoj hlab zis yog coj los ntawm kev txhaj tshuaj 2-3 ml ntawm ib qho 0.05% ntawm chlorhexidine bigluconate 1-2 zaug hauv ib hnub mus rau qhov zis, lub chav kawm yog 10 hnub, cov txheej txheem raug kho txhua lwm hnub. Intravaginally, 1 suppository 3-4 zaug hauv ib hnub rau 7-20 hnub, nyob ntawm seb qhov xwm ntawm tus kab mob. Ib qho tshuaj yaug thiab rau lub ntsej muag rau kev siv tshuaj pleev ib txwm muaj ntawv 2-3 zaug nyob rau ib hnub. Thaj: tshem cov zaj duab xis tiv thaiv los ntawm qhov chaw tsis txhob kov cov ntaub qhwv nrog koj cov ntiv tes, thiab siv rau qhov chaw ntawm daim tawv nqaij puas. Siv lub ntsej muag txhuam nrog lub nrig nrog koj cov ntiv tes kom lub qhov nplaum ntawm lub thaj kho cov ntaub qhwv.
Hauv xyoo 2013, WHO suav nrog 7% ntawm chlorhexidine bigluconate nyob rau hauv cov npe ntawm cov tshuaj tseem ceeb. Raws li cov lus pom zoo los ntawm WHO, txoj hlab ntaws caj dab (txoj hlab ntaws) yog kho tau 7% tshuaj, uas txo qhov muaj peev xwm kis tau ntau dua ntawm kev yug menyuam tshiab.
- kev kho mob ntawm lub paum (kab mob vaginosis, trichomoniasis, tsis hais tshwj xeeb, mob sib xyaw ua ke)
- kev tiv thaiv thaum muaj xwm ceev ntawm kev sib deev sib kis (mob syphilis, gonorrhea, trichomoniasis, mob chlamydia, ureaplasmosis)
- kev rov ua kom tiav ntawm kev yug me nyuam los npaj rau kev xa menyuam thiab kev tswj hwm lub sijhawm yug menyuam tom qab tus poj niam muaj kev pheej hmoo kis mob thiab kis mob
Lub paum suppositories tuaj yeem siv rau txhua qhov trimesters cev xeeb tub thiab thaum lactation. Qhov chaw mos paum me ntsis maj mam cuam tshuam rau cov qog ua ke, thaum tswj hwm microflora qhov paum. qhov chaw tsis tau teev muaj 3375 hnub
Vaginal suppositories (daim ntawv me nyuam mos)
Nkag rau hauv zos thiab sab nraud siv 0.5%
- kev kho mob ntawm qhov txhab, txhim kho, khawb, kub nyhiab, khawb
- kev kho thiab tiv thaiv kev kis kab mob ntawm daim tawv nqaij thiab cov qog ua kua
- siv rau hauv kev kho hniav (pom mob caj dab, stomatitis thiab periodontitis)
- kho pob txuv (ua ib feem ntawm txoj kev kho mob)
- daim tawv nqaij saib xyuas tom qab cov txheej txheem ua kom zoo nkauj (tho, tattooing, depilation)
- kev tiv thaiv kab mob microbes hauv qhov chaw pej xeem, hauv qhov
0.5% cawv tov ntawm chlorhexidine
- kev saib xyuas tes ntawm cov neeg kho mob, kws phais neeg, kho tawv nqaij ntawm thaj chaw ua haujlwm thiab txhaj tshuaj
- kev kho mob ntawm kev raug mob phais nrog tus mob ntev li ntawm 1-2 feeb
- kev ua kom huv ntawm cov khoom siv kho mob, cov cuab yeej kho hniav, cov chaw siv
0.05% aqueous tov ntawm chlorhexidine bigluconate
- ntxuav cov qhov txhab, puas tsuaj, khawb, kub nyhiab, khawb, ua kab tom
- siv rau hauv kev kho hniav (gingivitis, stomatitis, alveolitis, periodontitis)
- kho cov mob ENT (pharyngitis, laryngitis, tonsillitis, otitis media)
- kev tiv thaiv kab mob microbes hauv qhov chaw pej xeem, hauv qhov
- kev tiv thaiv kab mob sib kis
0.2% aqueous tov ntawm chlorhexidine bigluconate
- kev kho thiab kho kom rov zoo ntawm qhov chaw mos nyob rau hauv gynecology, urology thaum lub sij hawm kuaj mob cov txheej txheem
- ntxuav ntawm cov hniav cuav uas tshem tau
0.5% aqueous tov ntawm chlorhexidine bigluconate
- kev kho mob ntawm qhov txhab thiab kub hnyiab, kho cov mob scuffs thiab tawg ntawm daim tawv nqaij, qhib cov leeg nqaij
- kom tsis muaj kab mob ntawm cov khoom siv kho mob ntawm qhov kub kub txog 70 ° C
1% aqueous tov ntawm chlorhexidine bigluconate
- rau kev ua kom huv ntawm chav, cov cuab yeej huv huv, thiab lwm yam.
- kev kho mob ntawm thaj chaw phais thiab txhais tes ntawm tus kws phais ua ntej kev phais mob, tshuaj tua kab mob rau tawv nqaij, kev kho tom qab zoo thiab hlawv lub qhov txhab
Kev tsis haum rau yeeb tshuaj, dermatitis, kev fab tshuaj rau. Kev siv ntawm iodine tib lub sij hawm npaj tau yog qhov tsis tuaj yeem xav kom zam dhau kev txhim kho ntawm dermatitis. Chlorhexidine cov kev daws teeb meem yuav tsum tsis txhob siv los kho cov tshuaj pleev thiab kom yaug cov kab noj hniav.
Kev Ceev Faj
Siv nrog ceev faj thaum menyuam yaus.
Chlorhexidine tsuas yog siv los tiv thaiv STDs tsuas yog siv tshuaj kho mob thaum muaj xwm txheej ceev (kev sib deev hauv hnab looj tes, kev sib daj sib deev). Kev muab cov tshuaj chlorhexidine tso rau ntawm lub qhov zis tuaj yeem ua rau cov tshuaj lom neeg mob (tshwj xeeb nrog cov tshuaj tiv thaiv kom tsis haum tshuaj), uas thaum kawg tuaj yeem ua rau muaj teeb meem loj npaum li kev mob urethral nruj. qhov chaw tsis teev 1142 hnub .
Hom ntawm lub paum ntawm cov paumCov. Ua xua tuaj yeem khaus, khaus, tshwm sim tom qab tso tshuaj tawm tau. Los ntshav ntawm ntau intensities yog tau.
CawvCov. Ua xua, ua kom tawv nqaij qhuav, khaus, ua kom tawv nqaij, ua rau tawv nqaij, ua paug rau ntawm daim tawv nqaij ntawm tes (3-7 feeb) thaum siv cov gel, photosensitivity (qhov tshwm sim ntawm kev ua kom lub cev hloov pauv (feem ntau cov tawv nqaij thiab hnoos qeev ua rau ultraviolet hluav taws xob)). Hauv kev kho mob ntawm gingivitis - staining ntawm hniav txha hniav laus, tartar deposition, saj cuam tshuam. Kev ua kom tawv nqaij staining thiab calculus deposition tshwm sim nyob rau hauv cov ntaub ntawv ntawm lub sijhawm ntev siv cov tshuaj.
TshuajCov. Tsis tshua muaj neeg ua rau muaj kev tsis haum tshuaj, khaus, dhau mus tom qab cov tshuaj txuas mus ntxiv.
Thaum raug mob los ntawm cov tshuaj, nws tsis yog qhov nqus tsis haum; tso quav tawm yog qhia siv mis, xab npum me, gelatin lossis qe nyoos.
Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb, yog li ntawd, thaum muaj kev phiv, kev mob tshwm sim yog nqa tawm.
- Tsis pom zoo siv nrog iodine tsis pom zoo.
- Chlorhexidine yog sib xyaw nrog cov tshuaj ntxuav tes uas muaj ib pawg anionic (saponins, sodium lauryl sulfate, sulfonic acid, sodium carboxymethyl cellulose) thiab cov xab npum. Lub xub ntiag ntawm xab npum tuaj yeem ua rau chlorhexidine, yog li cov tshuaj ntxuav tes yuav tsum tau muab ntxuav kom huv ua ntej siv cov tshuaj.
- Nws tsim cov tshuaj lom neeg tov thaum tov nrog sodium hypochlorite (NaOCl) - para-chloraniline (n-NH2C6H4Cl). Muaj pov thawj tias parachloraniline yog lom (Burkhardt-Holm et al., 1999) kev sib txuas tsis tiav thiab tej zaum yuav ua rau kev tsim cov tshuaj methemoglobin.
- Ethanol txhim kho cov txiaj ntsig ntawm chlorhexidine.
Hais ntawm lub paum paum. Qhov chaw mos rau sab nraud tsis cuam tshuam rau qhov tshwm sim thiab zam ntawm lub paum ntawm qhov paum, vim tias cov tshuaj no yog siv intravaginally.
Kev daws thiab gel. Zam kom tsis txhob txais cov tshuaj rau hauv qhov txhab ntawm cov neeg mob nrog qhib craniocerebral kev raug mob, mob hlwb txha nraub qaum, perforation ntawm lub tympanic membrane. Yog tias cov tshuaj tov nkag mus rau cov kab mob ntawm lub qhov muag, lawv yuav tsum tau ntxuav sai thiab huv nrog dej. Cov Ntaub Ntawv Kev Nyab Xeeb (MSDS) rau chlorhexidine bigluconate.
Lub cev ntawm hypochlorite ntxuav hniav dawb cov tshuaj mus rau cov ntaub so ntswg uas yav tas los tau chwv nrog chlorhexidine-npaj tau yuav ua rau pom qhov xim av ntawm lawv. Cov nyhuv bactericidal nce nrog nce qhov kub ntawm cov tshuaj. Nyob rau qhov kub siab tshaj 100 ° C, cov tshuaj yaj yeeb tsis kho ib feem.
Kev daws teeb meem ntawm chlorhexidine ntsev tuaj yeem decompose (tshwj xeeb tshaj yog thaum rhuab thiab alkaline pH) nrog kev tsim cov nyiaj ntawm 4-chloroaniline, uas muaj cov khoom carcinogenic.
Cov ntaub ntawv tau piav qhia qhov twg? kev loj hlob ntawm methemoglobinemia thiab cyanosis nyob rau ntawm cov menyuam mos uas tsis tau yug ntxov hauv kev tawm tsam vim yog 4-chloroaniline lom qhov chaw tsis tau teev 284 hnub Cov. Tus tsim ncu tau nruab nrog humidifier nrog tov ntawm chlorhexidine, uas, thaum kho kom sov, tuaj yeem decompose rau 4-chloroaniline.
