Cov tshuaj Tio-Lipon-Novopharm: cov lus qhia rau kev siv

NtawmLOOJ CEEB
Ministry Order
kev saib xyuas kev noj qab haus huv ntawm Ukraine
12.11.13№ 968
Daim ntawv pov thawj rau npe
№UA/13320/01/01

LUS QHIA
rau kev siv tshuaj kho mob

TIO-LIPON - NOVOFARM
(TIO-LIPON-NOVOFARM)

Muaj pes tsawg leeg:
cov tshuaj nquag: thioctic acid,
1 ml ntawm kev daws muaj 30 mg ntawm thioctic (a-lipoic) acid,
zam txim : meglumine, macrogol 300, dej rau kev txhaj tshuaj.
Dosage daim ntawv. Kev daws rau Txoj kev lis ntshav.
Cov tshuaj pab pawg kho mob. Txhais tau tias ua rau lub plab zom mov thiab kev zom zaub mov muaj txiaj ntsig. PBX code A 16A X 01.
Soj ntsuam cov yam ntxwv.
Cov Khoom Qhia.Kev tiv thaiv thiab kho mob ntshav qab zib polyneuropathy, haus dej cawv neuropathy, kab mob siab (kab mob siab, mob ntsws, rog tsis zoo), nrog rau intoxication (piv txwv li: nceb, ntsev ntawm cov hlau hnyav).
Cov Yuav Tsum Muaj

Hypersensitivity rau thioctic (lip-lipoic) acid los yog rau lwm cov tshuaj ntawm cov tshuaj,

cov mob uas tuaj yeem ua rau cov kab mob lactic acidosis,

qhov tsis zoo ntawm lub raum thiab mob siab ua haujlwm.

Tsuas tshuaj thiab tswj hwm.Cov tshuaj raug muab rau cov tshuaj ua kua nqus dej ua kom zoo tom qab dhau los ua kua rau hauv 0.9% sodium chloride tov.
Cov neeg laus tau sau tseg ib hnub 20 ml ntawm ib qho kev daws hauv 250 ml ntawm 0.9% sodium chloride tov (sib npaug rau 600 mg ntawm thioctic (a-lipoic) acid hauv ib hnub). Hauv qhov xwm txheej hnyav heev, qhov kev noj tshuaj txhua hnub tau nce rau 900-1200 mg / hnub.
Kev tswj hwm kev mob yog nqa tawm maj mam - tsis nrawm tshaj 50 mg ntawm thioctic (a-lipoic) acid (uas sib haum rau 1.7 ml ntawm kev daws rau Txoj kev lis ntshav) ib feeb, lub sijhawm ntawm infusion yuav tsum yog tsawg kawg 30 feeb.
Kev daws daws npaj rau Txoj kev lis ntshav yuav tsum siv tam sim, thaum siv lub hnab tiv thaiv lub teeb.
Mob ntshav qab zib thiab haus dej cawv polyneuropathy. Thaum pib ntawm cov chav kawm ntawm kev kho mob, Tio-Lipon-Novofarm muab kev tso ntshav khov rau 1-2 lub lis piam. Tom ntej no, lawv hloov mus rau kev saib xyuas kev kho mob nrog noj cov ntawv ntawm thioctic (a-lipoic) acid rau kev tswj hwm qhov ncauj ntawm ib koob ntawm 600 mg rau ib hnub.
Daim siab mob. Cov tshuaj yog kws kho mob hauv koob tshuaj 600-1200 mg ntawm thioctic (a-lipoic) acid hauv ib hnub, nyob ntawm qhov mob hnyav ntawm tus neeg mob tus mob thiab kuaj pom ntawm lub xeev ua haujlwm ntawm lub siab.
Rau prophylaxis mob ntshav qab zib polyneuropathy, mob nyhav, mob siab, ntau npaum li cas ntawm cov tshuaj tau teem ib lub zuj zus, nyob ntawm: hnub nyoog, lub cev qhov hnyav ntawm tus neeg mob thiab mob hnyav ntawm tus kab mob. Nws yog ib qho tsim nyog yuav tsum pib kho nrog kev pib muab 10 ml ntawm qhov kev daws teeb meem hauv 250 ml ntawm 0.9% sodium chloride tov (sib npaug rau 300 mg ntawm thioctic (a-lipoic acid) ib hnub.
Kev phiv tshuaj
Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: kev hloov pauv los yog ua txhaum ntawm cov saj ntawm saj, nrog rau kev tswj hwm sai, cov kev xav ntawm hnyav nyob rau hauv lub taub hau, nce siab intracranial, kub flashes, nce hws, ua tsis taus pa ua tau. Qee qhov xwm txheej, tom qab kev tswj hwm ntawm lub cev, mob taub hau, kiv taub hau, pom zoo, ua kom tiav, thiab qhov muag tsis pom kev. Feem ntau, txhua qhov kev tawm tsam dhau ntawm nws tus kheej.
Los ntawm cov ntshav system: muaj pentchial hemorrhages nyob rau hauv mucous daim nyias nyias, daim tawv nqaij, thrombocytopathy, platelet tsis ua hauj lwm, hypocoagulation, hemorrhagic pob (purpura), thrombophlebitis.
Los ntawm cov hnyuv: hauv qee kis, nrog kev mob sai sai rau kev tswj hwm tshuaj, xeev siab, ntuav, raws plab, mob plab, uas dhau ntawm nws tus kheej, tau pom.
Los ntawm sab ntawm cov metabolism: vim tias txhim kho cov piam thaj hauv ntshav siab, cov ntshav qab zib yuav txo qis, uas yuav ua rau cov tsos mob ntawm lub qog ntshav nce siab, xws li kiv taub hau, tawm hws ntau dhau, mob taub hau, thiab tsis pom kev.
Los ntawm cov kab mob plawv: nrog kev tswj hwm sai, mob hauv thaj av ntawm lub plawv, tachycardia, uas dhau ntawm nws tus kheej, tuaj yeem pom.
Kev ua xua tsis haum: ntawm qhov chaw txhaj tshuaj, qhov tshwm sim ntawm urticaria thiab kev txhim kho ntawm eczema, pob txha pob, ua pob khaus, dermatitis, tsis tshua muaj - muaj kev tsis haum rau lub cev txawm tias ua ntej anaphylactic kev poob siab.
Cov tshuaj tiv thaiv hauv zos: qee zaum - hauv cov neeg mob uas muaj lub siab ntev, qhov mob siab yuav tshwm sim ntawm thaj chaw txhaj tshuaj ntawm Tio-Lipon-Novofarm.
Noj ntau dhau.Yog tias muaj kev noj haus ntau dhau, xeev siab, ntuav, mob taub hau yuav tshwm sim. Cov kab mob tshuaj lom mob lom neeg muaj peev xwm, thaum pib kho mob, ua rau muaj kev ntxhov siab psychomotor lossis quav cawv cuam tshuam nrog rau cov kev rau txim xws li kev mob loj dua tuaj yeem qaug dab peg thiab kev tsim kho cov kab mob lactic acidosis. Cov lus piav qhia txog kev qaug tshuaj lom neeg muaj feem ntau ntawm thioctic (a-lipoic) acid, xws li hypoglycemia, kev poob siab, rhabdomyolysis, mob txha pob txha tsis muaj leeg mob, kev mob ntshav siab, tau tawm ntawm kev mob hlwb (DIC), kev cuam tshuam ntawm lub hlwb kev ua haujlwm thiab cov kev ua haujlwm hauv lub cev (ntau yam hauv lub cev tsis ua haujlwm), tau txais.
Txoj kev kho kom zoo thaum kev haus cawv.
Yog tias muaj kev ua haujlwm tsis txaus ntseeg nrog kev qaug cawv nrog thioctic (a-lipoic) acid, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob tam sim ntawd thiab pib siv cov kev kho mob dav dav uas tau txiav txim los ntawm kev lom (namely, txhawb kev ntuav, tso pa tawm, siv hluav ncaig hluav taws, thiab lwm yam). Kev kho mob los ntawm kev kho mob kom thwm khwm, lactic acidosis thiab lwm yam cuam tshuam kev phom sij rau lub neej yuav tsum ua raws li cov ntsiab lus niaj hnub ntawm kev kho mob hnyav thiab nyob ntawm cov tsos mob. Kev siv cov tshuaj hemodialysis, hemoperfusion thiab kev lim dej rau kev tshem tawm sai ntawm thioctic (a-lipoic) acid tseem tsis tau lees tias qhov zoo.
Siv thaum cev xeeb tub lossis lactation.Kev siv ntawm thioctic (a-lipoic) acid thaum cev xeeb tub tsis pom zoo vim tias tsis muaj cov ntaub ntawv hauv chaw soj ntsuam. Tsis muaj cov ntaub ntawv hais txog kev nkag mus ntawm thioctic (a-lipoic) acid rau hauv cov kua mis, yog li nws tsis pom zoo kom siv nws thaum pub mis.
Cov menyuam. Tio-Lipon-Novofarm tsis pom zoo rau cov menyuam yaus thiab cov tub ntxhais hluas vim tias tsis muaj kev tshuaj xyuas ntau nrog cov tshuaj hauv pawg no ntawm cov neeg mob.
Cov yam ntxwv ntawm daim ntawv thov.Hauv kev kho mob ntawm cov neeg mob ntshav qab zib, kev tswj glycemic ntau yog tsim nyog. Qee qhov xwm txheej, nws yog ib qho tsim nyog yuav tau kho cov koob tshuaj hypoglycemic los tiv thaiv kev mob ntshav qab zib.
Thaum kho polyneuropathy, vim yog cov txheej txheem tsim dua tshiab, lub sijhawm luv luv ntawm qhov kev xav tau yog ua tau, nrog paresthesia nrog kev hnov ntawm "nkag mus ants."
Kev haus cawv tsis tu ncua yog qhov muaj kev pheej hmoo rau mob polyneuropathy thiab tej zaum yuav txo qis kev ua haujlwm ntawm Tio-Lipon-Novopharm. Yog li, nws raug nquahu kom tsis txhob haus dej cawv thaum kho nrog tshuaj. Tio-Lipon-Novofarm yuav tsum tsis txhob siv ib txhij nrog cov kev npaj muaj hlau (npaj hlau, magnesium, calcium), nrog rau cov khoom noj muaj mis nyuj uas muaj calcium.
Cov tshuaj yeeb yaj kiab yog photosensitive, yog li lub hwj yuav tsum tau muab tshem tawm lub ntim tsuas yog ua ntej siv.
Txoj kev lis ntshav daws yuav tsum tau tiv thaiv los ntawm tshav ntuj los ntawm kev tiv thaiv lawv nrog lub hnab tiv thaiv lub teeb. Hauv cov xwm txheej no, txoj kev npaj daws teeb meem tseem haum rau ntev tshaj ntawm 6 teev.
Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem. Cov tshuaj tsis cuam tshuam rau kev hloov tshuaj thaum lub sijhawm tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem, tab sis yog tias pom muaj cov kev mob tshwm sim ntawm cov tshuaj (saib "Cov Kev Phiv Rov Los"), nws yog ib qho tsim nyog yuav tsum tau zam qhov kev ua ub no.
Kev sib cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam. Thioctic (a-lipoic) acid ua si nrog ionic hlau ua haujlwm (piv txwv, cisplatin), yog li cov tshuaj muaj peev xwm txo cov nyhuv ntawm cisplatin.
Nrog cov suab thaj molecules (piv txwv, nrog kev daws levulose), thioctic (a-lipoic) acid cov ntaub ntawv sparingly soluble complex tebchaw.
Thioctic (a-lipoic) acid yog hlau chelator, yog li nws tsis tuaj yeem siv ua ke nrog cov hlau (hlau, hlau npaj).
Thioctic (a-lipoic) acid tuaj yeem txhim kho cov suab thaj txo qis ntawm insulin thiab / lossis lwm yam tshuaj tiv thaiv kab mob, yog li ntawd, tshwj xeeb tshaj yog thaum pib kho mob thioctic (a-lipoic) acid, kev soj ntsuam cov ntshav qab zib cov ntshav yog qhia. Txhawm rau tiv thaiv qhov pib ntawm cov tsos mob ntawm tus mob ntshav qab zib tsawg nyob rau qee kis, nws yuav tsum tau txo qis koob tshuaj insulin thiab / lossis tus neeg sawv cev rau tshuaj tiv thaiv kab mob hauv lub qhov ncauj.
Cov chaw muag tshuaj.
Cov Tshuaj Hauv Tshuaj Thioctic (a-lipoic) acid yog cov tshuaj sib tov hauv lub cev thiab ua lub luag haujlwm ntawm coenzyme hauv oxidative decarboxylation ntawm a-keto acids, ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm kev tsim lub zog hauv lub cell. Pab txo cov ntshav qab zib thiab nce glycogen hauv nplooj siab. Kev ua kom tsis haum los yog ua kom cov metabolism ntawm thioctic (a-lipoic) acid vim yog intoxication los yog ntau cov khoom ua kom lwj (piv txwv, ketone lub cev) ua rau muaj kev cuam tshuam ntawm aerobic glycolysis. Thioctic (a-lipoic) acid yuav muaj nyob rau ob hom physiologically dhia (oxidized thiab txo) nrog cov tshuaj antitoxic thiab antioxidant. Thioctic (a-lipoic) acid cuam tshuam rau cov metabolism ntawm cov roj cholesterol, koom nrog kev tswj hwm cov lipid thiab carbohydrate metabolism, txhim kho daim siab ua haujlwm (vim hepatoprotective, antioxidant, detoxification effect). Thioctic (a-lipoic) acid yog qhov zoo sib xws hauv cov khoom muaj tshuaj rau B vitamins.
Cov Tshuaj Pharmacokinetics Thioctic (a-lipoic) kua qaub ua rau muaj kev hloov pauv ntau thaum pib hla los ntawm daim siab. Cov kev cuam tshuam tseem ceeb ntawm cov neeg txawv txav hauv lub kaw lus muaj thioctic (a-lipoic) acid raug pom muaj. Nws yog tawm los ntawm lub raum feem ntau yog nyob rau hauv daim ntawv ntawm metabolites. Qhov tsim ntawm metabolites tshwm sim los ntawm sab saw oxidation thiab kev sib txuas. Ib nrab-lub neej ntawm thioctic (a-lipoic) acid los ntawm cov ntshav cov ntshav yog 10-20 feeb.
Cov yam ntxwv ntawm kws tshuaj.
Qhov yooj yim lub cev thiab tshuaj: ntshiab cov xim daj lossis xim ntsuab-daj.
Incompatibility. Kev daws ntawm thioctic (a-lipoic) acid yog tsis sib xws nrog cov kua dej qab zib, Ringer txoj kev daws teeb meem thiab nrog cov kev daws teeb meem uas tuaj yeem ua nrog SH-pawg lossis disulfide bonds.
Hnub tas sij hawm. 2 xyoos
Cia rau cov neeg mob. Muab cia rau hauv lub ntim thawj ntawm qhov kub tsis tshaj 25 ° C. Txhob nyob ze cov me nyuam.
Vim tias qhov tseeb thioctic (a-lipoic) acid yog nkag siab rau lub teeb, cov vials yuav tsum tau muab cia rau hauv cov thawv ntim khoom kom txog thaum lawv siv tam sim.
Ntim. 10 ml lossis 20 ml hauv lub hwj, 5 lub raj ntim hauv cov hlwv ntsej muag ntim, 1 lossis 2 blister sawb ntim rau hauv lub thawv ntawv thawv.
Cov qeb so. Los ntawm tshuaj.
Chaw tsim tshuaj paus LLC lub tuam txhab "Novopharm-Biosynthesis".
Qhov chaw nyob. Ukraine, 11700, Zhytomyr cheeb tsam, Novograd-Volynsky, st. Zhytomyr, 38.
Hnub kawg ntawm kev hloov kho zaum kawg.

Sposib zastosuvannya li dozi

Cov tshuaj yog muab ntawm lub forearm ntawm sab hauv mottled Txoj kev lis ntshav ntawm infusion ntawm 0.9% ntawm sodium chloride.

Doroslim txhais tau tias yog 1 zaug ntawm doba 20 ml rosin hauv 250 ml ntawm 0.9% rosin sodium chloride (sib npaug rau 600 mg ntawm acid (a-lipoic acid ntawm doba). Hauv arc ntawm hnyav vipads, Kuv yuav ntxiv ib lub koob tshuaj ntawm nce txog 900-1200 mg / dob.

Txhawm rau tswj cov tshuaj ntau dua tsis tshaj 50 mg ntawm cov kua qaub (a-lipoic acid) (uas yog 1.7 ml ntawm tus nqi rau infusion) rau cov nyiaj, cov nqi infusion tsis yog tsawg dua 30 zaug.

Qhov kev npaj rau Txoj kev lis ntshav rozschin swb yog tsis tau txais los ntawm txoj kev, nrog txhua pob yeej.

Mob ntshav qab zib thiab haus dej cawv polyneuropathy. Ntawm txoj kev cob, lub chav kawm ntawm Tіo-Lіpon-Novofarm kaw rau sab hauv, txuas ntxiv 1-2 zaug. Nadal yuav tsum hloov mus rau pidtrimuyuyu txoj kev kho nrog lіkarskimi cov ntaub ntawv tіoktovoi (a-lіpopovo) acid thiab rau qhov ncauj tswj hwm ntawm ib koob ntawm 600 mg rau ib dob.

Txais lub qhov cub. Cov tshuaj yog sau tseg nyob rau hauv koob tshuaj 600-1200 mg kua qaub (a-lipoic acid) rau kev kho mob ntxiv, tus neeg mob mob hnyav, thiab muaj kev kuaj thiab kuaj pom ntawm lub chaw ua haujlwm ntawm lub siab.

Txog rau prophylaxis Mob ntshav qab zib polyneuropathy, mob nyhav, mob lub siab, koob tshuaj yuav tsum tau kho rau cov tshuaj ib leeg zuj zus, tsis hais yam twg: mob, nyhav thiab hnyav npaum li cas. Kho kho qhov xav tau qhov koob tshuaj cob txog 10 ml rau 250 ml 0.9% rau sodium chloride (sib npaug rau 300 mg ntawm acid (a-lipoic acid)).

Kev tawm tsam

Los ntawm sab ntawm lub paj hlwb thiab qhov hloov khoom nruab nrog: Zmina abo smackov smakovыh vidchuttіv, nrog ib tug shyvdkomnogo qhia vlvdchuttya mob hnyav nyob rau hauv lub taub hau, pidvyshennya nrog torsion tuav, dej ntas, pidvisthennuyu pitlivist, teeb meem ua pa. Tus vicious ntog, sab hauv mob taub hau, txhav tas li, judomis, diplopia, tsis pom lub zora raug mob. Muaj ntau vipadkiv us_kazan_ qhia dhau los ntawm lawv tus kheej.

Los ntawm ob sab ntawm cov ntshav: petechial hemorrhages nyob rau hauv cov qog ua pa, tawv nqaij, thrombocytopathy, ua tsis taus pa thrombocyte muaj nuj nqi, hypocoagulation, hemorrhagic visipa (ntshav), thrombophlebitis fueled.

Los ntawm sab ntawm txoj kev nyom: nyob rau hauv okremich vipadka, nrog shvidkuyu nrog tshuaj nyob rau hauv lub cev, xeev siab, bluing, raws plab, mob plab, thiab yelp triggered ntawm nws tus kheej.

3 sab obmіnu rechovin: vim tias cov piam thaj hauv siab nce ntxiv, peb tuaj yeem txo cov ntshav qab zib hauv cov ntshav, los ntawm kev peb tuaj yeem hnov cov tsos mob ntawm cov tsos mob, xws li kaw, nce kub, mob taub hau, thiab mob khaub thuas.

Los ntawm sab ntawm lub plawv-nkoj system: nrog shvidkuyu sab hauv qhia tau tuaj yeem ua kom muaj zog ntawm lub plawv dilyantsya, tachikardiya, scho kom dhau ntawm nws tus kheej.

Kev ua xua tsis haum: lub hli dhau los, peb tuaj yeem yeej lub caij nplooj ntoo hlav thiab lub caij nplooj zeeg thiab lub xyoo, roj av, roj av, tawv nqaij, tawv nqaij thiab cov xeb ua xua ua rau muaj kev poob siab.

Cov tshuaj tiv thaiv: Inodi - ntawm tus neeg mob nrog qhov paub tab ntawm lub cev hauv feem ntau ntawm cov sij hawm, Lonu-Novofarm yuav mob siab dua.

Tshuav tsis tau

Nyob rau hauv cov ntaub ntawv ntawm overdose, winding li nudotiness, bluing, mob taub hau. Cov ntsiab lus lom toxicological tuaj yeem ua rau cob ntawm qhov zoo li ntawm lub siab lub ntsws ntawm lub cev, tab sis qhov xav tau los koom rau hauv kev kho mob, xws li qaug dab peg feem ntau thiab kev txhim kho ntawm lactic acidosis. Buli otrimanі cov lus nug xws іntoksikatsіynih naslіdkіv tuam tsev koob tshuaj tіoktovoї (a-lіpoєvoї) acid gіpoglіkemіya yak, poob siab, rabdomіolіz, GOSTR necrosis skeletal m'yazіv, gemolіz, disemіnovane vnutrіshnosudinne zgortannya (FEP), prignіchennya funktsії lub taub hau mozk uas rozladi vnutrіshnіh organіv (multiorganna nedostatnіst )

Kws kho mob tuaj nyob rau ntawm Intoxication.

Yog tias muaj kev phom sij txaus ntshai, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob txhua yam hauv tsev, thiab nws yuav tsum tau cais tawm ntawm lawv txoj kev xav saib xyuas lawv tus kheej li kev saib xyuas kev noj qab haus huv.Zoo li no, kev qaug dab peg feem ntau, lactic acidosis thiab ua rau qaug cawv, uas tuaj yeem raug teeb meem nrog lub neej, yuav tsum ua kom tiav ntawm random kom txog thaum tus tsos mob tseem ceeb tshaj plaws tau hais tawm. Kev tsim cov tshuaj hemodialysis, hemoperfusion thiab kev siv ntawm kev qhia nrawm ntawm cov kua qaub (a-lipoic acid) thiab dosi tsis tau nqa cov haujlwm ntau dhau.

Zastosuvannya ntawm lub sijhawm vag_nostnost abo yearvannya mis

Kev tshwm sim ntawm cov kua qaub (a-lipo) acid thiab teev ntawm kev ua ub no tsis raug pom zoo los ntawm qhov muaj cov ntaub ntawv raug cai. Danish txog kev nkag mus ntawm cov kua qaub (a-lipo) cov kua qaub hauv lub mis, cov kua mis yog ruam, yog li ntawd txhav ntawm lub mis hauv thawj xyoo tsis pom zoo.

Tio-Lіpon-Novofarm tsis pom zoo kom muab cov menyuam yaus los ntawm kev muaj nyob hauv kev sim tshuaj rau kev npaj ntawm ib qeb ntawm cov neeg mob.

Nta zastosuvannya

Nyob rau hauv cov ntaub ntawv ntawm mob mob rau chukrovia mob ntshav qab zib, qhov tsim nyog ib feem tswj yog glikemії. Nyob rau hauv cov ntaub ntawv ntawm vicious ntog, koj yuav tsum tau kho sai sai qhov ntau thiab tsawg ntawm cov teeb meem tsis tshua muaj teeb meem rau lub hom phiaj kom tau txais gogoglіkemії.

Rau ib nrab teev ntawm tus kab mob polieneuropathy, muaj ntau cov txheej txheem tsim tshuaj, ntau qhov kev cia siab me ntsis, tom qab ntawd kuv xav saib xyuas ob peb zaug nrog "Goosebump".

Kev yoo mov haus cawv yog qhov ua kom muaj qhov mob polyneuropathy ntau dua thiab uas tuaj yeem txo cov txiaj ntsig ntawm Tio-Lippon-Novopharm. Nws raug nquahu tias koj yuav tsum saib xyuas cawv thiab haus cawv ib teev twg. Tsis yog tam sim ntawd kos npe rau Tio-Lіpon-Novofarm tam sim ntawd nrog tshuaj, uas yuav tsum tau noj cov hlau (npaj zaliza, magnesium, calcium), tab sis kuj muaj cov khoom noj siv mis, uas yog tsim nyog los noj calcium.

Cov tshuaj yog nkag siab, qhov ntawd yog lub raj mis xa khoom rau packing tilka yam tsis muaj kev ncua ua ntej cov neeg muaj yeej.

Інфузійні розчини slіd txhawm rau txhawm rau tshem txhua hom kev pw tsaug zog zoo, nrog kev pabcuam ntawm cov pob khoom ntiag tug. Hauv cov kev npaj siab no ntawm kev npaj, Txoj kev lis ntshav rozchin yuav ploj rau hnub tom qab ntau dua 6 xyoo.

Vz зmodiya nrog іnshimi lіkarskimi zaboba uas іnshі vidi vzakmodiiy

Tioktova (a-lіpoєva) acid yog rov ua nrog lub ntsej muag hlau nkaus xwb (piv txwv, nrog cisplatin), yog li cov tshuaj tuaj yeem txo cov nyhuv ntawm cisplatin.

Nrog cov lwg me me ntawm dib (piv txwv li, nrog qhov ua rau levulose) th_oktova (a-lіpoєva) acid Kuv yuav lees paub qhov tseem ceeb uas cuam tshuam nrog cov txheej txheem spoluki.

Tioktova (a-lіpoпva) acid yog cov hlau ntxhw; yog li ntawd, nws tsis tuaj yeem ua cov hlau tawv ib zaug (npaj zaliza, magnіyu).

Tioktova (a-lipo) acid tuaj yeem muab cov tshuaj insulin zoo dua thiab / lossis qis dua tiv thaiv kab mob, tshwj xeeb tshaj yog nyob ntawm cob ntawm i-uric acid (a-lipo) kev tshuaj xyuas tas li, ntsuas. Txhawm rau tau txais txiaj ntsig ntawm cov tsos mob ntawm hypoglycaemia hauv okimich vipads, koj yuav tsum muaj qis dua qhov ncauj ntawm qhov ncauj thiab / lossis qhov ncauj tiv thaiv kab mob.

Cov tub ceev xwm Pharmacological

Cov Tshuaj Hauv Tshuaj. Tioktova acid (a-lіpoєva) yog kua qaub ов cystic acid, uas ua ke hauv lub cev thiab hauv lub luag haujlwm ntawm coenzyme hauv oxidative decarboxylation ntawm a-keto acids; Txau qhov hloov pauv ntawm cov ntshav qab zib hauv cov ntshav thiab nce rau hauv cov ntshav qab zib hauv lub siab. Ua tsis tiav cov kua qaub (a-lipo) acid thiab cov tshuaj muaj keeb muaj cov mob ua rau muaj kev lom zem ntau ntxiv rau qee yam khoom hauv kev faib khoom (piv txwv, ketone hom) ua rau muaj kev puas tsuaj ntawm aerobic glycol. Tіoktova (a-lіpoєva) acid tuaj yeem pom hauv ob hom kev ua haujlwm ntawm physiologically (oxidized thiab txuas ntxiv dua tshiab), uas yog lub npe hu ua antitoxic thiab antioxidant. Tioktova (a-lipoic) acid yog txhaj rau qhov sib pauv ntawm cov cholesterol, saib xyuas cov lipid thiab carbohydrate tsis tu ncua, polyphenol ua haujlwm ntawm lub siab (hepatoprotective, antioxidant, antioxidant muaj nuj nqi). Tіoktova (a-lіpoєva) acid yuav zoo dua rau cov tub ceev xwm pharmacological txog rau pawg V.

Cov Tshuaj Pharmacokinetics. Tіoktova (a-lіpoєva) acid paub txog qhov tseem ceeb thaum lub sijhawm pib hla ntawm lub cub tawg. Ua kom ceev qhov tseem ceeb ntawm cov khoom nruab nrab hauv cov kab ke muaj cov kua qaub (a-lipo) acid. Nws mob siab rau tau nirkas hauv viglyad metabolites. Pom zoo cov metabolism hauv kev tshwm sim ntawm oxidation ntawm txoj kev tom ntej ua kom zoo thiab cov conjugate. Lub sijhawm thaum cov kua qaub (a-lipo) ua kua qaub thiab ntshav kua los ua 10-20 hvilin.

Umovi zberigannya

Zberigati nyob rau hauv thawj lub ntim ntawm qhov kub ntawm 25 ° С. Zberigati nkag tsis tau rau menyuam yaus.

Ntawm zvіyazku zim, sch ti tioktova (a-lіpoєva) acid rhiab rau dії svіtla, vials іlіd zberіgati cartn thawv ntim li tо tsis cuam tshuam іх zososuvannya.

10 ml lossis 20 ml rau ib lub vial, 5 vials ib daim ntim contour ntim, 1 abo 2 contour charunk ntim rau hauv cov thawv ntawv thawv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage cov ntaub ntawv ntawm thiolipone tawm:

zaj duab xis-ntsiav tshuaj: lub plhaub daj los yog daj nrog lub tint ntsuab, qhov tseem ceeb yog lub teeb daj, 300 mg txhua qhov yog puag ncig, biconvex, 600 mg ib qho yog oblong, ntawm ib sab nrog ib qho kev ceeb toom (hauv daim npav xim pob 1 tsaus thawv iav, hauv ib lub thawv ntawm 30 lossis 50 ntsiav tshuaj, hauv daim ntawv qhwv ib pob paj ntawm 1-3 lub blisters, hauv ib pob ntawm 10 pcs.),
mloog zoo rau kev npaj ntawm kev daws rau kev tswj hwm kev saib xyuas: pob tshab, lub ntsej muag ntsuab-daj (hauv pob ntawv ntawm 10 ampoules lossis 1-2 pob ntawm 5 ampoules).

Muaj pes tsawg leeg ntawm 1 ntsiav tshuaj ntawm thiolipone:

cov tshuaj nquag: thioctic acid (lipoic acid) - 300 lossis 600 mg,
Cov khoom siv pabcuam (300/600 mg): calcium stearate monohydrate - 5 / 8,2 mg, lactose monohydrate (mis nyuj qab zib) - 91.5 / 80.6 mg, sodium stearyl fumarate - 5 / 8,2 mg, hypromellose - 5 / 8.2 mg, sodium carboxymethyl hmoov txhuv nplej siab (primogel) - 17.5 / 28.7 mg, colloidal silicon dioxide - 7.5 / 12.3 mg, microcrystalline cellulose - 50/41 mg, magnesium stearate - 5 / 8,2 mg magnesium hydrosilicate - 13.5 / 24.6 mg,
plhaub (300/600 mg): Opadry II (hypromellose - 3.4 / 4.1 mg, macrogol 4000 –1.1 / 1.3 mg, lactose monohydrate - 3 / 3.6 mg) - 10/12 mg, cov xim tha xim - 2.5 / 3 mg, titanium dioxide (E 171) - 2 / 2.4 mg, kua roj vanish raws quinoline daj (E 104) - 0.4 / 0.48 mg, kua roj vanish raws indigo carmine ( E 132) - 0.05 / 0.06 mg, kua roj vanish raws li hnub ci hnub ci daj (E 110) - 0.05 / 0.06 mg.

Muaj pes tsawg leeg ntawm 1 ml Tiolipon mloog zoo:

cov tshuaj nquag: thioctic acid (lipoic acid) - 30 mg,
Cov khoom ua haujlwm pabcuam: propylene glycol, ethylene diamine, dej rau kev txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Thioctic acid (alpha-lipoic acid) yog ib qho kev tiv thaiv kabmob (khi dawb radicals), yog tsim nyob rau hauv lub cev thaum lub sijhawm oxidative decarboxylation ntawm alpha-keto acids.

Nws muaj cov tshuaj tiv thaiv hypolipidemic, hepatoprotective, hypoglycemic thiab hypocholesterolemic effect.

Raws li coenzyme ntawm mitochondrial multienzyme complexes, nws siv feem hauv oxidative decarboxylation ntawm alpha-keto acids thiab pyruvic acid. Nws pab txhawb kom muaj glycogen ntxiv rau hauv daim siab thiab txo qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav, nrog rau kev kov yeej cov tshuaj insulin.

Los ntawm cov kev ua haujlwm biochemical, lipoic acid yog nyob ze rau cov vitamins B. Nws yog qhov tsim nyog rau cov khoom noj carbohydrate thiab lipid, txhawb cov metabolism hauv cov roj cholesterol, txhim kho daim siab ua haujlwm thiab trophic neurons.

Cov Tshuaj Pharmacokinetics

Kev tswj fwm: C_max (qhov siab tshaj plaws) yog 0.025–0.038 mg / ml, lub sijhawm kom ncav cuag nws yog 10–11 feeb, thaj chaw hauv qab nkhaus-sijhawm yog kwv yees li 0.005 mg / ml,
cov thawj coj ntawm qhov ncauj: lipoic acid yog ua tiav thiab sai sai los ntawm txoj hnyuv, thaum nqus tau tsawg dua thaum noj tshuaj nrog zaub mov. Lub sijhawm kom mus txog qhov siab tshaj plaws yog los ntawm 40 txog 60 feeb.

Bioavailability yog 30%. Lipoic acid muaj cov "kev dhau thawj" los ntawm daim siab. Raws li qhov tshwm sim ntawm sab saw hlau oxidation thiab sib txuas, tsim ntawm metabolites tshwm sim.

Qhov ntim ntawm kev faib tawm yog kwv yees li 450 ml / kg. Thioctic acid thiab nws cov metabolites yog ua kom lub raum tso tawm (80-90%). Qhov kev tshem tawm ib nrab-lub neej ua rau 20-50 feeb. Tag nrho cov ntshav tshem tawm yog 10-15 ml / min.

Cov Yuav Tsum Muaj

lactase deficiency, lactose intolerance, qabzib-galactose malabsorption (ntsiav tshuaj),
cev xeeb tub thiab lactation,
hnub nyoog txog 18 xyoo
ib leeg tsis quav ntsej rau ib qho twg ntawm cov tshuaj.

Tus neeg txheeb ze (thiolipone raug xaj nyob rau hauv kev saib xyuas ntawm tus kws kho mob):

ntshav qab zib mellitus (ntsiav tshuaj),
ntev mentsis cawv (ntsiav tshuaj).

Cov lus qhia rau kev siv Thiolipone: txoj kev thiab ntau npaum li cas

Thiolipone noj qhov ncauj nrog qhov me me ntawm cov dej, tsis ntxo.

Cov ntsiav tshuaj tau noj ib hnub ib zaug nyob rau ntawm lub plab khoob, li 30 feeb ua ntej noj mov thawj zaug.

Qhov tshuaj rau txhua hnub yog 600 mg.

Qhov tsawg kawg nkaus ntawm kev kawm yog 3 hli (hauv qee kis, yuav tsum tau kho ntev dua).

Txhaj tshuaj tov

Thiolipon muab tshuaj ua leeg ntshav. Yav dhau los, cov ntsiab lus yuav tsum tau diluted hauv isotonic sodium chloride tov.

Hauv cov qauv mob hnyav, 300-600 mg tau muab tshuaj ib hnub ib zaug nyob rau hauv daim ntawv ntawm cov leeg ntshav nrog kua (rau 50 feeb).

Lub sijhawm siv yog los ntawm 2 txog 4 lub lis piam. Tom qab qhov kawg ntawm lub sijhawm no, tus neeg mob hloov mus rau kev tswj hwm qhov ncauj ntawm cov tshuaj (300-600 mg ib hnub) nrog rau kev kawm tsawg kawg 3 hlis.

Sab sij huam

Cov teeb meem tshwm sim: hypoglycemia (cuam tshuam nrog txhim kho cov piam thaj hauv siab), kev fab tshuaj tsis haum (suav nrog urticaria, anaphylactic shock).

Lwm qhov kev ua txhaum cai:

tshuaj noj: dyspepsia, suav nrog xeev siab, ntuav, kub siab,
txhaj tshuaj daws teeb meem: tsis tshua muaj tshwm sim - pov thawj, ua kom tiav, ua kom pom qhov ntshav tawm hauv cov tawv nqaij thiab cov qog ua kua, ua kom mob plab, mob ntshav tawm, mob plab, nrog rau kev tswj hwm sai ntawm kev daws teeb meem - kev mob siab ntxiv rau hauv lub ntsej muag (qhov pom ntawm hnyav hauv lub taub hau), ua pa nyuaj (tsis xav tau kev kho ntxiv).

Cov lus qhia tshwj xeeb

Cov neeg mob ntshav qab zib yuav tsum tau soj ntsuam cov ntshav qabzib tas mus li, tshwj xeeb yog pib ntawm cov tshuaj. Qee qhov xwm txheej, tus kws kho mob tuaj yeem txo qhov tshuaj insulin / qhov ncauj qhov ncauj ntshav qab zib kom tiv thaiv kev mob ntshav qab zib.

Thaum lub sijhawm kev kho mob, koj yuav tsum tsis kam haus cawv, txij li tib lub sijhawm muaj qhov ua kom tsis muaj zog ntawm cov tshuaj thioctic acid.

Ampoules nrog cov mloog zoo yuav tsum muab tshem tawm ntawm lub ntim tam sim ntawd ua ntej siv, uas cuam tshuam nrog cov duab kev sib txuas ntawm cov tshuaj nquag. Thaum lub sijhawm infusion, nws raug nquahu kom tiv thaiv lub khob tov los ntawm lub teeb (nws yog qhov ua tau siv lub teeb-tiv thaiv lub hnab, txhuas ntawv ci). Qhov sij hawm ntau tshaj ntawm kev khaws cia ntawm cov tshuaj npaj tau yog 6 teev.

Yeeb tshuaj sib cuam tshuam

cisplatin: txo qis hauv nws cov txiaj ntsig (cisplatin pom zoo kom noj tom qab noj su lossis yav tsaus ntuj),
magnesium / hlau npaj, nrog rau cov khoom noj siv mis ua vim muaj cov calcium uas muaj nyob hauv lawv: txij li thioctic acid reacts nrog ionic hlau tso rau lub sijhawm, lub sijhawm pom zoo rau kev siv cov tshuaj no yog tav su lossis yav tsaus ntuj,
cawv (ethanol): qhov txo qis hauv kev kho mob ntawm Thiolipon,
insulin thiab qhov ncauj hypoglycemic tus neeg sawv cev: txhim kho lawv qhov kev txiav txim.

Txoj kev ntawm daim ntawv thov

Tshuaj Thiolipone nws yog npaj rau kev npaj ntawm kev daws rau infusion tom qab ua ntej dilution hauv ib qho isotonic sodium chloride tov.
Hauv cov ntawv hnyav ntawm cov ntshav qab zib lossis dej cawv polyneuropathy, 300-600 mg 1 zaug hauv ib hnub yuav tsum tau muab rau cov tshuaj txau ntshav dej. Txoj kev lis ntshav ntawm lub plab yuav tsum tau muab nyob hauv 50 feeb.
Cov tshuaj raug pom zoo rau kev siv hauv 2-4 lub lis piam.
Tom qab ntawd koj tuaj yeem txuas ntxiv noj cov tshuaj hauv ib koob ntawm 300-600 mg ib hnub twg. Lub sijhawm yam tsawg kawg nkaus ntawm kev kho mob nrog cov ntsiav tshuaj yog 3 hli.

Kev cuam tshuam nrog lwm yam tshuaj

Alpha - lipoic acid (raws li kev daws rau Txoj kev lis ntshav) txo cov nyhuv ntawm cisplatin. Nrog rau siv ua ke nrog insulin thiab lwm qhov ncauj hypoglycemic, ib qho kev nce ntawm hypoglycemic nyhuv yog pom. Alpha-lipoic acid cov ntaub ntawv nyuaj nyuaj soluble cov tebchaw nrog suab thaj molecules (piv txwv, kev daws teeb meem levulose), yog li ntawd, nws tsis sib xws nrog cov kua qab zib, Ringer txoj kev daws teeb meem, nrog rau cov tebchaw (suav nrog lawv cov kev daws teeb meem) uas cuam tshuam nrog disulfide thiab SH pawg. Cov.

Pharmacological pawg

Txhais tau tias cuam tshuam rau lub plab zom mov thiab cov txheej txheem hauv lub cev zom zaub mov. ATS code 16A X 01.

Kev tiv thaiv thiab kho mob ntshav qab zib polyneuropathy, haus dej cawv neuropathy, kab mob siab (kab mob siab, mob ntsws, rog tsis zoo), nrog rau intoxication (piv txwv li, nceb, ntsev ntawm cov hlau hnyav).

Kev phiv tshuaj

Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: kev hloov pauv los yog ua txhaum ntawm cov saj ntawm saj, nrog rau kev tswj hwm sai, ib qho kev xav ntawm qhov hnyav ntawm lub taub hau, nce siab intracranial, kub flashes, nce tawm hws, ua tsis taus pa ua tau. Qee qhov xwm txheej, tom qab kev coj noj coj ua, mob taub hau, kiv taub hau, pom zoo, ua pov thawj, thiab qhov muag pom kev tsis zoo. Feem ntau, txhua qhov kev tawm tsam dhau ntawm nws tus kheej.

Ntshav: muaj pentchial hemorrhages nyob rau hauv mucous daim nyias nyias, daim tawv nqaij, thrombocytopathy, plahaum tsis ua haujlwm ntawm lub plab, hypocoagulation, hemorrhagic pob (purpura), thrombophlebitis.

Los ntawm cov hnyuv: hauv qee kis, nrog kev tswj hwm sai ntawm cov tshuaj, xeev siab, ntuav, raws plab, mob plab, uas dhau ntawm nws tus kheej, tau pom.

3 sab ntawm cov metabolism: raws li kev txhim kho cov piam thaj hauv ntshav siab ntxiv, cov ntshav qab zib yuav txo qis, uas yuav ua rau cov tsos mob ntawm lub qog ntshav zoo ib yam, xws li kiv taub hau, tawm hws ntau dhau, mob taub hau, thiab cuam tshuam rau lub siab.

Los ntawm cov kab mob plawv: nrog kev tswj hwm sai, mob hauv thaj av ntawm lub plawv, tachycardia yuav tshwm sim, dhau ntawm nws tus kheej.

Kev ua xua tsis haum : ntawm qhov chaw txhaj tshuaj, qhov tshwm sim ntawm urticaria thiab kev txhim kho ntawm eczema, pob txha caj qaum, khaus, dermatitis, tsis tshua muaj - muaj kev tsis haum rau lub cev txawm tias ua ntej anaphylactic poob siab.

Cov tshuaj tiv thaiv hauv zos: qee zaum - cov neeg mob lub cev tsis nco qab nyob ntawm thaj chaw txhaj tshuaj ntawm Tio-Lipon-Novofarm tuaj yeem hnov qhov mob khaus.

Noj ntau dhau

Yog tias muaj kev noj haus ntau dhau, xeev siab, ntuav, mob taub hau yuav tshwm sim. Cov chaw kuaj mob toxicological thaum pib ntawm kev kho mob ua rau psychomotor ntxhov siab lossis dab noj hnub thiab feem ntau cuam tshuam nrog kev rau txim xws li kev chua leeg ntau thiab kev txhim kho cov mob lactic acidosis.

Txoj kev kho kom zoo thaum kev haus cawv.

Yog tias muaj kev ua haujlwm tsis txaus ntseeg nrog kev qaug cawv nrog thioctic (a-lipoic) acid, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob tam sim ntawd thiab pib ua cov kev kho mob dav dav uas tau txiav tawm ntawm cov tshuaj lom (xws li, txhawb kev ntuav, lub plab zom zaub mov, ua kom muaj cov pa hluav taws, thiab lwm yam). Kev kho mob los ntawm kev kho mob kom thwm khwm, lactic acidosis thiab lwm yam cuam tshuam kev phom sij rau lub neej yuav tsum ua raws li cov ntsiab lus niaj hnub ntawm kev kho mob hnyav thiab nyob ntawm cov tsos mob. Kev siv cov tshuaj hemodialysis, hemoperfusion thiab kev limtiam rau kev rho tawm sai ntawm thioctic (a-lipoic) acid tsis tau nqa cov txiaj ntsig ntseeg tau.

Siv thaum cev xeeb tub thiab lactation

Kev siv ntawm thioctic (a-lipoic) acid thaum cev xeeb tub tsis pom zoo vim tias tsis muaj cov ntaub ntawv hauv chaw soj ntsuam. Tsis muaj cov ntaub ntawv hais txog kev nkag mus ntawm thioctic (a-lipoic) acid rau hauv cov kua mis, yog li nws tsis pom zoo kom siv nws thaum pub mis.

Tio-lipon-Novofarm tsis pom zoo rau cov menyuam yaus thiab cov tub ntxhais hluas vim tias tsis muaj kev tshuaj xyuas ntau nrog cov tshuaj hauv pawg no ntawm cov neeg mob.

Daim ntawv thov nta

Hauv kev kho mob ntawm cov neeg mob ntshav qab zib, kev tswj glycemic ntau yog tsim nyog. Qee qhov xwm txheej, nws yog ib qho tsim nyog yuav tau kho cov koob tshuaj hypoglycemic los tiv thaiv kev mob ntshav qab zib.

Thaum kho polyneuropathy, vim yog cov txheej txheem tsim dua tshiab, lub sijhawm luv luv ntawm qhov kev xav tau yog ua tau, nrog los ntawm paresthesia nrog qhov kev xav ntawm "nkag cov nqaj."

Kev haus cawv tsis tu ncua yog qhov muaj kev pheej hmoo rau mob polyneuropathy thiab tej zaum yuav txo qis cov txiaj ntsig ntawm Tio-lipon-Novopharm.

Cov tshuaj yog photosensitive, yog li lub vials yuav tsum tau muab tshem tawm los ntawm cov ntim tsuas yog ua ntej siv.

Txoj kev lis ntshav daws yuav tsum tau tiv thaiv los ntawm tshav ntuj los ntawm kev tiv thaiv lawv nrog lub hnab tiv thaiv lub teeb. Hauv cov xwm txheej no, txoj kev npaj daws teeb meem tseem haum rau qhov siab tshaj ntawm 6:00.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj Thioctic (a-lipoic) acid yog ib yam khoom uas ua ke hauv lub cev thiab ua lub luag haujlwm ntawm coenzyme hauv oxidative decarboxylation ntawm a-keto acids, ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm kev tsim lub zog hauv lub cell.

Cov Tshuaj Pharmacokinetics Thioctic (a-lipoic) kua qaub ua rau muaj kev hloov pauv ntau thaum pib hla los ntawm daim siab. Cov kev cuam tshuam tseem ceeb ntawm cov neeg txawv txav hauv lub kaw lus muaj thioctic (a-lipoic) acid raug pom muaj. Nws yog tawm los ntawm lub raum feem ntau yog nyob rau hauv daim ntawv ntawm metabolites. Qhov tsim ntawm metabolites tshwm sim los ntawm sab saw oxidation thiab kev sib txuas. Ib nrab-lub neej ntawm thioctic (a-lipoic) acid los ntawm cov ntshav cov ntshav yog 10-20 feeb.

Cia rau cov neeg mob

Muab khaws cia rau hauv cov khoom ntim thawj zaug uas kub tsis tshaj 25 ° C. Tsis txhob pub me nyuam ncav cuag.

Vim tias qhov tseeb thioctic (a-lipoic) acid yog rhiab rau qhov kev ua ntawm lub teeb, lub hwj yuav tsum muab cia rau hauv cov thawv ntim khoom kom txog thaum lawv siv tam sim.

10 ml lossis 20 ml hauv lub hwj, 5 lub raj ntim hauv cov hlwv ntsej muag ntim, 1 lossis 2 blister ntim rau hauv ib pob ntawv los ntawm daim ntawv qhia.