Kuv noj tshuaj > Tshuaj Kho Mob

Los ntawm cov txiaj ntsig ntawm kev tshawb nrhiav kev ua haujlwm ntawm University of Alabama hauv Birmingham, nws tau hais tias kev siv Verapamil cuam tshuam txog kev txo qis ntawm cov piam thaj hauv cov neeg muaj ntshav qab zib. Qhov kev cia siab pom zoo no tau tsim tawm ntawm Lub Chaw Tiv Thaiv Kab Mob Ntshav Qab Zib ntawm University of Alabama hauv Birmingham, thiab cov txiaj ntsig tau tshaj tawm nyob rau lub Ib Hlis tawm ntawm Kev Tshawb Fawb Ntshav Qab Zib thiab Kev Tshuaj Ntsuam Xyuas (2016.01.021). Niaj hnub no, lub chaw coj ua thawj zaug kev sim tshuaj kho mob ntawm Verapamil (nrog kev txhawb nqa los ntawm JDRF).

Yulia Khodneva, MD, Ph.D., kws tshawb nrhiav thiab cov tub ntxhais kawm sab tom tsev kawm ntawv ntawm Lub Chaw Tiv Thaiv Kev Noj Tshuaj, koom tes ntawm Lub Chaw Kho Mob Ntshav Qab Zib, soj ntsuam qhov sib txheeb ntawm calcium channel blockers, Verapamil tshwj xeeb, thiab yoo ntshav cov ntshav qabzib ntawm 5,000 cov neeg laus cov neeg kuaj mob ntshav qab zib uas tuaj koom rau hauv REGARDS txoj kev kawm.

Tus Kws Kho Mob ntawm Tshuaj Julia Khodneva.

Tag nrho ntawm 1484 cov neeg mob noj calcium channel blockers koom nrog cov qauv ntawm cov neeg laus cov neeg mob ntshav qab zib mellitus, ntawm uas 174 coj Verapamil.

Cov ntaub ntawv tau pom tias cov neeg mob noj calcium calcium blockers muaj, nruab nrab, 5 mg / dl (0.3 mmol / L) cov ntshav qabzib tsawg dua piv rau cov tsis tau noj cov tshuaj no. Hauv cov neeg mob uas siv Verapamil, ntshav dej muaj cov ntshav qabzib tsawg dua li 10 mg / dL (0.6 mmol / L), piv nrog cov neeg mob noj lwm calcium channel blockers.

Txheeb cais kuj qhia tau qhov sib txawv sib txawv hauv cov ntshav qabzib hauv cov neeg mob noj verapamil ua ke nrog cov tshuaj insulin thiab tshuaj hauv qhov ncauj: hauv cov neeg noj Verapamil, tshuaj noj ntawm qhov ncauj thiab insulin, qib ntawm cov piam thaj hauv cov ntshav cov ntshav tau tsawg dua 24 mg / dl (

1.3 mmol / L) hauv cov neeg mob ntshav qab zib uas tau noj tsuas yog verapamil thiab insulin, qhov kev txo qis hauv cov ntshav hauv lub ntsej muag raug kaw 37 mg / dl (2 mmol / L).

"Vim tias nws tsuas yog qhov kev kawm hla qhov chaw xwb tom qab uas peb yuav tsum ua cov kev soj ntsuam kev tshawb fawb randomized Txawm li cas los xij, peb tseem tsis tau paub txog qhov muaj txiaj ntsig ntawm kev sib raug zoo ntawm kev siv Verapamil thiab txo cov ntshav qabzib hauv cov neeg muaj ntshav qab zib, tab sis peb pom tseeb tias kev noj cov tshuaj yuav pab txo qis ntshav qab zib "- hais tias Professor Khodneva.

Cov txiaj ntsig hauv kev sib txuas ua ke ntawm cov neeg mob uas muaj hom 1 mob ntshav qab zib mellitus lossis nrog mob ntshav qab zib hom 2 mob ntshav qab zib mellitus uas tau noj Verapamil ua ke nrog insulin xav tsis thoob.

"Qhov cov ntshav qabzib hauv cov neeg mob ntawm pab pawg no piv rau cov tsis tau noj Verapamil yog 37 mg / dl (2 mmol / l) - qhov no yuav luag ntau dua plaub npaug dua li hauv tag nrho cov piv txwv ntawm cov neeg mob ntshav qab zib"- txuas ntxiv xib fwb Khodneva. "Qhov no coj peb mus rau lub tswv yim tias Verapamil siv tau tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib hom 1 thiab cov neeg mob ntshav qab zib hom 2, cov hlwb ua kom yuag. uas muaj kev puas tsuaj tsis zoo. Pom meej, cov tshuaj ua rau cov txheej txheem theem, tshwj xeeb tshaj yog rau cov neeg uas muaj kev puas tsuaj tsis zoo hauv cov hlwb beta. ".

"Dr. Julia Khodneva tau ua txoj haujlwm zoo uas tau tshawb xyuas ntau qhov tseem ceeb ntawm cov ntaub ntawv thiab pom tias cov tshuaj Verapamil muaj cov txiaj ntsig zoo rau kev ua kom cov ntshav qabzib hauv ntshav qab zib mellitus"Anat Shalev, tus thawj coj ntawm Lub Chaw Saib Xyuas Kev Mob Ntshav Qab Zib nyob ntawm University of Alabama ntawm Birmingham, tus kws tshawb fawb txog kev sim saib mob ntawm Verapamil.

"Cov kev pauv hauv cov ntshav nyob hauv qib uas tau sau cia hauv cov neeg mob noj verapamil yog piv nrog qhov txo qis hauv Hb_A1c li ntawm 1% Cov. Los ntawm qhov uas peb tuaj yeem xaus tias Verapamil ua tib yam nkaus li tau pom zoo siv cov tshuaj ntshav qab zib. Tsis tas li ntawd, qhov sib txawv loj nyob hauv cov ntshav qabzib hauv cov neeg mob noj insulin yog raws li peb qhov kev xav tseem ceeb uas Verapamil pab rov ua haujlwm ntawm pawg beta ua haujlwm " - ntxiv Dr. Shalev.

University of Alabama ntawm Birmingham tau tshaj tawm txog kev sim tshuaj rau Verapamil thaum Lub Kaum Ib Hlis 2014, thiab tau pib nyiam cov neeg mob rau txoj kev tshawb no thaum Lub Ib Hlis 2015. Cov kev tshwm sim thawj zaug, nyob rau hauv lub hauv paus uas nws yuav muaj peev xwm los soj ntsuam cov txiaj ntsig ntawm Verapamil ntawm hom 1 mob ntshav qab zib mellitus, tau npaj cia kom txog li ntawm 18 lub hlis.

Thaum lub sijhawm ntsuas, ib txoj hauv kev yuav raug sim uas txawv ntawm cov qauv uas twb muaj rau kev kho mob ntshav qab zib, tsom rau kev kho kom rov qab zoo rau cov leeg hlwb, uas yog siv los tsim cov tshuaj insulin los tswj cov ntshav qabzib.

Raws li kev tshawb fawb tau ntau xyoo, cov kws tshawb fawb hauv tsev kawm ntawv qib siab tau ua pov thawj tias cov ntshav siab nyob hauv qib siab ua rau tib neeg lub cev tsim cov txheej txheem TXNIP ntau dua, cov qib uas nce hauv beta hlwb teb rau hauv kev txhim kho cov ntshav qab zib mellitus, txawm li cas los xij, nws lub luag haujlwm hauv cell biology yav tas los tsis paub hauv kev xyaum. tsis muaj dab tsi. Kev noj cov ntshav TXNIP ntau dhau nyob rau hauv pancreatic beta hlwb ua rau lawv tuag, cuam tshuam kev tsim tawm ntawm insulin, thiab yog li pab txhawb kev txhim kho cov ntshav qab zib mellitus.

Cov kws tshawb fawb hauv tsev kawm qib siab kuj pom tias Verapamil, siv dav los kho cov ntshav siab, lub plawv dhia tsis xwm yeem, thiab migraines, tuaj yeem txo qhov theem ntawm TXNIP protein los ntawm kev txo qis cov tshuaj calcium hauv beta hlwb. Hauv cov nas ntshav muaj ntshav qabzib cov ntshav siab tshaj 300 milligrams rau ib deciliter (16.6 mmol / L), Kev kho mob Verapamil ua rau muaj kev txo cov calcium ntau txaus ua rau cov ntshav qab zib ceased kom tshwm.

Hauv lub sijhawm, Scottish cov kws tshawb fawb tau pom tias AMPK cuam tshuam cov kev cai ntawm kev ua pa ntawm kev pw tsaug zog.

Verapamil, Verapamil yog ib qho antiarrhythmic, hypotensive thiab antianginal tus neeg sawv cev ntawm cov pab pawg qeeb calcium calcium blockers, voltage-depend calcium calcium blocker ntawm L-hom. Kev ua ntawm verapamil yog txhawm rau thaiv kom muaj calcium calcium (nyob rau sab hauv lub cell daim nyias nyias) thiab qis qis cov transmembrane calcium tam sim no.

Cov nyhuv antiarrhythmic ntawm Verapamil yog kom qeeb thiab ua kom lub plawv tsis sib haum, txwv tsis pub atrioventricular thiab sinoatrial conduction, thiab txo qhov automatism ntawm lub plawv mob. Vim qhov kev txiav txim ntawm Verapamil, muaj kev nthuav dav ntawm cov hlab ntsha ntawm lub plawv thiab nce ntshav coronary ntau dua, txo qis hauv cov pa oxygen xav tau ntawm lub plawv.

Hauv cov txheej txheem ischemic hauv myocardium, verapamil pab txo qhov tsis txaus ntawm qhov xav tau thiab muab cov pa oxygen rau lub plawv los ntawm kev nce ntshav thiab kev siv zoo dua thiab kev siv nyiaj txiag ntau dua ntawm cov pa oxygen.

Cov tshuaj Verapamil raug kho rau hypertrophic cardiomyopathy, idiopathic hypertrophic subaortic stenosis, mob ntshav siab, mob ntshav qab zib, mob ntshav tawm ntawm lub plawv, nrog rau angina pectoris, postinfarction angina, angina pectoris, mob plawv atrial fibrillation, mob plawv atrial fibrillation, tshwj tsis yog WPW syndrome).

Verapamil yog ua nyob rau hauv ntau daim ntawv sau cov tshuaj:

cov ntsiav tshuaj (zaj duab xis-yeeb yaj kiab, xim-txheej, ua ntev ntev),
jelly taum
txhaj tshuaj siv
daws rau Txoj kev lis ntshav (kev tswj hwm dej).

Verapamil yog ua raws li cov npe lag luam tawm nram qab no: Verpamil, Veracard, Verogalid, Isoptin, Lecoptin, Caveril, Falicard, Phenoptin, Vepamil, Verapamil, Calan, Cardilax, Dilacoran, Falicard, Finoptin, Ikacor, Iproveratril, Isoptin, Isoptin.

Mob ntshav qab zib mellitus

Mob ntshav qab zib mellitus, mob ntshav qab zib (raws li ICD-10 - E10-E14), mob ntshav qab zib mellitus (los ntawm Greek 6, _3, ^ 5, ^ 6, ^ 2, `4, _1,` 2, - "tso zis tsis txaus") - ib pawg ntawm endocrine Cov kab mob hauv lub cev ua rau lub cev ncua ntev li ntawm cov ntshav qabzib (qab zib) hauv cov ntshav vim tsis muaj ntshav qab zib (ntshav qab zib 1) lossis txheeb ze (ntshav qab zib 2) pancreatic hormone insulin deficiency.

Ntshav qab zib yog ua ke los ntawm ib qho kev ua txhaum txhua hom cov metabolism: carbohydrate, rog, protein, dej-ntsev thiab ntxhia, thiab tuaj yeem ua rau muaj kev cuam tshuam loj heev hauv cov kab mob plawv, mob raum tsis ua haujlwm, hlab ntaws, puas tsuaj rau retina, ua tsis tiav erectile.

Cov tsos mob tshaj plaws ntawm cov ntshav qab zib yog nqhis dej (DM 1 thiab DM 2), tsis hnov tsw ntawm acetone los ntawm lub qhov ncauj thiab acetone hauv cov zis (DM 1), txo qhov hnyav (DM 1, nrog DM 2 hauv cov theem tom ntej), nrog rau kev tso zis ntau dhau, mob rwj ntawm ob txhais ceg, qhov mob tsis zoo.

Cov neeg mob ntshav qab zib tas mus li yog cov ntshav qabzib ntau nyob rau hauv cov zis (cov piam thaj hauv cov zis, glucosuria, glycosuria), ketones hauv cov zis, acetone hauv cov zis, acetonuria, ketonuria), muaj cov protein tsawg nyob hauv cov zis (proteinuria, albuminuria) thiab hematuria (occult ntshav, hemoglobin, ntshav liab nyob hauv cov zis). Ntxiv rau, pH ntawm cov zis nyob rau hauv cov ntshav qab zib yog feem ntau hloov mus rau sab acidic.

Type 1 diabetes mellitus, hom ntshav qab zib hom 1, (insulin-tiv thaiv tub rog, tub rog hluas) (ICD-10 - E10) yog tus kabmob autoimmune ntawm endocrine system pom los tsis cov tshuaj insulin tsis txaus, vim tias qhov ua kom lub cev tsis muaj zog, rau cov laj thawj tseem tsis tau paub meej, tawm tsam thiab rhuav tshem lub hlwb pancreatic beta hlwb uas tsim cov tshuaj insulin. Ntshav Qab Zib 1 tuaj yeem cuam tshuam rau tus neeg ntawm lub hnub nyoog twg, tab sis tus kab mob feem ntau loj hlob hauv cov menyuam yaus, cov hluas thiab cov neeg laus hnub nyoog qis dua 30 xyoo.

Nyem thiab qhia cov lus nrog koj cov phooj ywg:

Hom Ntshav Qab Zib 2 mellitus, hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) (ICD-10 - E11) yog ib hom kab mob tsis muaj kabmob tiv thaiv kabmob. tus txheeb ze insulin deficiency (qhov tshwm sim ntawm nws yog ib qho nce ntxiv ntawm cov piam thaj hauv cov ntshav, vim qhov kev ua txhaum ntawm kev cuam tshuam ntawm kev cuam tshuam ntawm cov tshuaj insulin nrog cov nqaij mos). Ntshav qab zib Hom 2 feem ntau cuam tshuam rau cov neeg hnub nyoog 40 xyoo. Cov ua kom muaj tus kab mob kuj tsis to taub tag nrho, tab sis cov neeg muaj rog muaj kev pheej hmoo.

Kev ntsuam xyuas ntshav hauv qab no yog siv rau kev kuaj mob ntshav qab zib mellitus thaum ntxov, nrog rau kev saib xyuas tus kab mob: yoo ntshav qab zib (feem ntau yog ntsuas hauv tsev, glucometer yog siv rau kev ntsuas ntshav) thiab kuaj ntshav kuaj, suav nrog kuaj ntshav qabzib (kuaj ntshav qab zib) qabzib kam rau ua), glycosylated hemoglobin test (glycated hemoglobin, Hb_A1c) thiab kev kuaj ntshav dav dav (txo qis ntawm cov leukocytes qhia tias tsis muaj cov thyroid tsis txaus).

Chav ntsuas ntawm kev ntsuas ntshav ntshav yog mmol / litre (hauv cov tebchaws nyob sab hnub poob, glycemia feem ntau ntsuas hauv mg / deciliter).

Sau ntawv

Cov lus ceeb toom thiab cov lus qhia meej rau cov xov xwm "Verapamil ua rau cov ntshav qabzib tsawg dua hauv cov ntshav qab zib."

University of Alabama ntawm Birmingham, Lub Tsev Kawm Ntawv ntawm Alabama ntawm Birmingham, UAB yog lub xeev (pej xeem) tsev kawm ntawv, yog ib ntawm peb lub tsev kawm ntawv qib siab hauv tsev kawm ntawv qib siab hauv Alabama. Hauv nws daim ntawv niaj hnub no, lub tsev kawm ntawv tau muaj txij li xyoo 1969 (hauv lub tsev kawm ntawv raws lub hauv paus ntawm lub tsev kawm ntawv raug tsim, kev qhia ntawv tau pib txij xyoo 1936).

18700 undergraduate thiab kawm tiav me nyuam.

Lub tsev kawm ntawv muab kev cob qhia hauv lub moj khaum ntawm 140 txoj kev kawm hauv 12 lub tsev kawm txuj ci, uas cov kws tshwj xeeb hauv kev ua haujlwm ntawm tib neeg, kev sib raug zoo, kev coj cwj pwm, kev lag luam, engineering thiab tshuaj yog kev kawm. Lub tsev kawm ntawv kho mob tshwj xeeb tshaj yog nyob hauv kev kho hniav, kho qhov muag, kws tu neeg mob thiab kev noj qab haus huv rau pej xeem.

Tshawb nrhiav ntshav qab zib thiab chaw kho mob xyaum - Cov Ntawv Xov Xwm ntawm International Diabetes Federation (IDF) luam tawm rau cov kws tshaj lij kho mob thiab cov kws tshawb fawb hauv chaw kho mob, tshaj tawm cov txuj ci txheej txheem keeb kwm zoo tshaj plaws thiab cov kws tshaj lij hauv kev saib xyuas cov ntshav qab zib thiab thaj chaw muaj feem. Cov ntawv xov xwm luam tawm los ntawm pawg Elsevier.

Cov kev tshawb fawb soj ntsuam (sim), kev sim kho mob - kev tshawb fawb tshawb fawb los ntawm kev koom tes nrog tib neeg txhawm rau txhawm rau ntsuas kev nyab xeeb thiab ua tau zoo ntawm cov tshuaj tshiab, nthuav cov kev taw qhia rau kev siv cov tshuaj uas twb paub lawm lossis cov khoom siv tshuaj kho mob.

Cov chaw kuaj mob yog ib qho tseem ceeb nyob rau hauv kev txhim kho cov tshuaj lossis cov cuab yeej siv tshuaj kho mob, ua ntej lawv rau npe thiab pib siv ntau hauv kev siv tshuaj kho mob.

JdrfJuvenile Diabetes Research Foundation yog kev siab hlub tsim tsa xyoo 1970 uas pab txhawb nqa kev kawm txog hom ntshav qab zib hom 1. Lub hauv paus chaw haujlwm ntawm lub koom haum yog nyob hauv New York, nws cov ceg yog nyob rau ntau lub xeev Asmeskas, thiab txawv teb chaws (hauv Australia, Canada, Denmark, Israel, Netherlands thiab UK).

Tus kws kho mob ntawm Philosophy, PhD, Ph.D. Philosophiæ, Kws Kho Mob , nyob hauv University of Oxford - Tus Kws Kho Mob ntawm Philosophy, D.Phil. - hauv cov teb chaws txawv teb chaws qhov no yog kev kawm ntawv qib muab rau cov neeg thov tom qab kev npaj thiab kev tiv thaiv ntawm kev ua haujlwm tsim nyog - cov kws kho mob tawm. Lub npe heev ntawm cov degree muaj kev sib cav ncaj qha rau kev xav, nws yog theej khoom plig rau kab ke.

Hauv kev kawm hauv Lavxias, kev kawm ntawv ntawm Doctor of Philosophy sib raug zoo tshaj plaws mus txog qib uas yog Doctor of Philosophy.

Nyob hauv tebchaws Asmeskas, tus kws kho mob uas kawm tiav qib Science uas twb muaj lawm hauv ib lub tsev kawm ntawv qib siab (Sc.D. - Doctor of Science) kuj suav tias yog Ph.D.

Cov kev tshawb fawb tom qab kawm tiav, kev kawm tom qab kawm, kev kawm tom qab lawb - nyob rau Western Europe, North America thiab Australia, kev tshawb fawb tawm los ntawm tus kws tshawb fawb uas nyuam qhuav tau txais Ph.D. Raws li, tus kws tshawb fawb koom nrog hauv qhov kev kawm no hu ua cov tub ntxhais kawm postdoctoral.

Cov calcium calcium blockers, qeeb calcium calcium blockers, BMKK, calcium antagonists - cov tshuaj tiv thaiv cov tshuaj tiv thaiv cov tshuaj uas ua rau hauv cov qauv ntawm cov ntsiav tshuaj, dragees, cov tshuaj ua haujlwm thiab cov tshuaj txhaj uas muaj tib lub tshuab ntawm kev nqis tes ua, tab sis txawv hauv ntau lub zog, suav nrog pharmacokinetics, cov nyhuv lub plawv dhia, xaiv nqaij.

Lub tshuab tseem ceeb ntawm kev ua haujlwm ntawm calcium channel blockers yog kev txwv tsis pub nkag rau ntawm calcium ions los ntawm qhov chaw sib cais mus rau cov leeg nqaij ntawm lub plawv thiab cov hlab ntsha los ntawm qeeb L-hom calcium channel. Cov calcium calcium blockers, txo qhov kev ua kom zoo ntawm Ca 2+ ions hauv cardiomyocytes thiab cov leeg nqaij vascular muaj zog, nthuav tawm cov leeg ntshav ntawm cov hlab ntsha thiab cov leeg ntshav ntawm cov hlab ntsha thiab cov hlab ntsha, thiab muaj cov nyhuv vasodilating.

Thawj tus neeg sawv cev tseem ceeb hauv tsev kho mob calcium calcium blockers, verapamil, tau nyob rau xyoo 1961 los ntawm kev sim ua kom sib txuas ntxiv ntawm cov tshuaj papaverine, uas muaj cov nyhuv vasodilating. Xyoo 1966, muaj tshuaj tiv thaiv kab mob calcium thib ob, nifedipine, tau tsim kho, thiab xyoo 1971, diltiazem. Verapamil, nifedipine thiab diltiazem hnub no yog cov neeg sawv cev kawm feem ntau ntawm calcium channel blockers.

TXAWV (Cov laj thawj rau thaj tsam thiab ntau haiv neeg sib txawv ntawm cov hlab ntshav hlab ntsha), ib qhov kev txhawb nqa los ntawm National Institutes of Health (NIH), yog ib txoj kev tshawb nrhiav hauv lub tebchaws uas xav tau cov lus qhia ntxiv ntawm cov xwm txheej uas ua rau muaj kev pheej hmoo ntawm kev mob plawv.

Cov tshuaj insulin, insulin yog protein ntau ntawm peptide xwm, uas tau tsim hauv beta hlwb ntawm pancreatic islets ntawm Langerhans. Cov tshuaj insulin muaj cov txiaj ntsig zoo hauv cov metabolism hauv yuav luag txhua cov ntaub so ntswg, thaum nws txoj haujlwm tseem ceeb yog txo (tswj hwm li qub) piam thaj (ntshav qab zib) hauv cov ntshav.

Cov tshuaj Insulin kuj nce permeability ntawm plasma membranes rau cov piam thaj, ua kom cov glycolysis tseem ceeb enzymes, txhawb kev tsim cov glycogen hauv daim siab thiab cov leeg nqaij los ntawm cov piam thaj, thiab txhim kho cov synthesis ntawm cov protein thiab cov rog.Ntxiv rau, insulin inhibits kev ua haujlwm ntawm cov enzymes uas zom cov rog thiab glycogen.

Txoj Kev Kawm Hla, kev tshawb fawb hla ib ntu, kev tsom xam hauv cov ntsiab lus teb - ib qho ntawm hom kev tshawb fawb, suav nrog kev tsom xam ntawm cov ntaub ntawv sau rau ib qho, qee lub sijhawm.

Randomized tswj mus sib hais txawm yog kev tshawb nrhiav, RCT, sim tswj kev sim, kev sim tswj kev sim, RCT - ib hom kev tshawb fawb, feem ntau muaj kev sim kho mob, uas nws cov neeg koom tau muab faib ua ob pawg, cov duab random. Hauv thawj pawg, qhov kev tshawb nrhiav kev kawm yog ua, hauv ob, kev tswj hwm, tus qauv txheej txheem lossis cov placebo siv.

Pancreatic hlwb, islets of Langerhans - tsub zuj zuj ntawm cov tshuaj hormones tsim (endocrine), feem ntau hauv tus Tsov tus tw ntawm cov txiav.

Muaj tsib hom hlwb pancreatic:

Glucagon secreting alpha cells (lub ntuj tsim los tiv thaiv lub cev)
Beta cells paim leeg insulin (siv cov protein ua receptor uas ua cov suab thaj rau lub cev lub cev, ua kom glycogen synthesis hauv daim siab thiab cov leeg, inhibit gluconeogenesis),
Somatostatin-ua kom zais cov av qab ntsev (tiv thaiv kev zais ntawm ntau cov qog),
PP hlwb ua zais pa paug rau polypeptide (txwv tsis pub tso lwm tus txiav tawm thiab txhawb lub plab zais pa),
Epsilon hlwb fim ghrelin (txhawb kev noj mov).

Hauv tsab xov xwm "Verapamil txo qis ntshav qab zib hauv ntshav qab zib mellitus", cov hlwb pancreatic tau to taub zoo li namely beta hlwbCov. Glycated hemoglobin, glycosylated hemoglobin, glycogemoglobin, hemoglobin A1c, Hb_A1c - kev qhia txog biochemical ntawm cov ntshav, qhia txog cov piam thaj hauv cov ntshav nyob hauv lub sijhawm ntev (txog li peb lub hlis).

1% Hb_A1c_, uas Dr. Anat Shalev hais txog kev raug rau cov ntsiab lus

1.3-1.4 mmol / liter. Txawm hais tias pom qhov tsis tseem ceeb ntawm qhov ntsuas tau no, ua rau Hb txo qis_A1c tsuas yog 1% pom zoo tias: qhov tshwm sim ntawm kev txiav tawm lossis tuag ua rau ntawm qhov kev mob kabmob ntawm lub cev voos txo qis los ntawm 43%, qhov muaj feem ua rau muaj kev pheej hmoo tawm zuj zus (uas tuaj yeem ua rau kev phais - cataract rho tawm), thiab kev muaj feem ntawm kev mob plawv txo qis los ntawm 16% tsis txaus. Thioredoxin Kev Sib Txuas Khoom Noj Protein, TXNIP, thioredoxin-sib cuam tshuam protein - ib qho protein encoded los ntawm TXNIP gene hauv tib neeg lub cev. TXNIP yog ib tug tswv cuab ntawm alpha-arrestin protein tsev neeg (koom nrog rau cov kev cai ntawm lub teeb liab sib kis hauv HVHF (G-protein coupled receptors).

TXNIP inhibits qhov ua haujlwm antioxidant ntawm thioredoxin, ua rau kev tsub zuj zuj ntawm hom kab mob oxygen oxygen thiab lub cev kev ua haujlwm ntxhov siab. TXNIP tseem ua raws li kev tswj hwm ntawm cov metabolism hauv lub cev thiab "kev ntxhov siab" ntawm cov tshuaj endoplasmic reticulum, thiab tuaj yeem ua cov tshuaj tua hlav.

TXNIP yog feem ntau cuam tshuam ncaj qha rau hyperglycemia (hyperglycemia ua rau oxidative kev nyuab siab los ntawm kev txwv tsis pub lub luag haujlwm ntawm thioredoxin reductase (tsuas yog paub cov enzyme uas txo thioredoxin).

Rau antianginal tshuaj muaj xws li tshuaj rau kev kho mob ntawm angina pectoris.

Hma-Parkinson-Dawb Syndrome, WPW syndrome yog qhov kev mob ua ntej los ntawm lub plawv, feem ntau yog los ntawm kev mob qia, tsis tshua muaj los ntawm paroxysmal tachyarrhythmias (atrial flutter, atrial fibrillation, supraventricular reciprocal tachyarrhythmias).

Wolff-Parkinson-White syndrome feem ntau ua rau nws tus kheej tawm tsam keeb kwm ntawm cov kab mob plawv - mitral valve prolapse, hypertrophic cardiomyopathy, Ebstein anomaly. Mob raum tsis ua hauj lwm (raws li ICD-10 - N17-N19) - cov tsos mob ntawm lub raum tsis zoo, ua rau muaj kev cuam tshuam ntawm nitrogen, electrolyte, dej, thiab lwm hom metabolism, uas tuaj yeem tshwm sim, suav nrog oliguria, polyuria, proteinuria (tag nrho cov protein hauv cov zis) , glucosuria (ketonuria tuaj yeem koom nrog ntshav qab zib), hloov pauv ntawm cov zis acidity, uremia, hematuria, ntshav liab, dyspepsia, kub siab.

Mob raum tsis ua hauj lwm (mob raum tsis ua hauj lwm, raws li ICD-10 - N17) - kev mob sai sai ntawm lub raum muaj nuj nqi nrog qhov txo qis hauv kev lim dej thiab rov kho dua.

Mob raum tsis ua hauj lwm (CRF, raws li ICD-10 - N18) yog qhov xwm txheej, uas yog los ntawm kev muaj mob raum, kev tuag ntawm lub raum maj mam tshwm sim. Cov feem ntau ua rau lub raum tsis ua haujlwm yog ntshav qab zib mellitus (

33% ntawm tus neeg mob) thiab ntshav siab (txoj hlab ntshav) siab (

25% ntawm tus neeg mob). Feem ntau ntawm lwm qhov, qhov ua rau lub raum tsis ua haujlwm yog qhov tseeb lub raum.

Qhov yooj yim tshaj plaws thiab siv tau txoj hauv kev los txhawm rau hloov pH ntawm cov zis yog cov ntawv kuaj mob ntawm pH ntawm cov zis, txawm hais tias muaj ntshav qab zib nws yog qhov zoo dua los siv cov ntawv rau ketones.

Kev pham - kev ua haujlwm rog, qhov hnyav nce vim yog cov nqaij adipose vim yog los ntawm kev noj zaub mov ntau dhau thiab / lossis txo kev siv lub zog. Niaj hnub no, kev rog yog suav tias yog kev muaj mob ntsig txog metabolic (raws li ICD-10 - E66), kev txhim kho thaum muaj hnub nyoog, pom los ntawm kev nce hauv lub cev nyhav dhau los, feem ntau vim yog kev txuam nrog ntau ntawm cov ntaub so ntswg adipose.

Kev pham yog nrog los ntawm kev nce ntxiv ntawm cov kabmob ntawm tus kabmob thiab tuag. Niaj hnub no, nws tau tsim tau tias kev rog yog ib qho ntawm cov kev ua kom muaj ntshav qab zib hom 2.

Thaum sau xov xwm hais tias Asmeskas cov kws tshawb fawb tau tsim muaj kev sib txuas ntawm kev noj Verapamil thiab txo qis cov ntshav qabzib hauv cov neeg mob ntshav qab zib mellitus, cov ntaub ntawv siv yog cov ntaub ntawv thiab siv Internet portals, cov vev xaib DiabetesResearchClinicalPractice.com, Tshuaj. com, NIH.giv, JDRF.org, GeneCards.org, ScienceDaily.com, Med.SPbU.ru, VolgMed.ru, Wikipedia, ntxiv rau cov ntawv tshaj tawm hauv qab no:

Leia Yu. Ya. "Kev tshuaj xyuas qhov tshwm sim ntawm kev kuaj ntshav thiab kuaj cov zis." Kev luam tawm lub tsev MEDpress-qhia, 2009, Moscow,
Henry M. Cronenberg, Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, "Ntshav qab zib thiab carbohydrate metabolism tsis txaus". Kev luam tawm lub tsev "GEOTAR-Media", 2010, Moscow,
A. John Kamm, Thomas F. Lusher, Patrick W. Serruis (cov kws kho mob) “Kab mob ntawm lub plawv thiab cov hlab ntshav. Cov Lus Qhia ntawm European Society of Cardiology. " Kev luam tawm lub tsev "GEOTAR-Media", 2011, Moscow,
Peter Hin, Bernhard O. Boehm “Mob ntshav qab zib. Kev kuaj mob, kho mob, tswj kab mob. " Kev luam tawm lub tsev "GEOTAR-Media", 2011, Moscow,
Potemkin V.V. “Endocrinology. Lus qhia rau cov kws kho mob. ” Koom haum kho mob cov ntaub ntawv luam tawm Lub Tsev, 2013, Moscow,
Jacques Wallach “Kev Ntsuam Xyuas Kws Muaj Mob. Phau Ntawv Kho Mob Ua Haujlwm. " Exmo Kev Tshaj Tawm Tsev, 2014, Moscow,
Tolmacheva E. (editor) "Vidal 2015. Siv Vidal. Tshuaj nyob hauv Lavxias. ” Vidal Rus Kev Tshaj Tawm Tsev, 2015, Moscow.

Cov ntawv sau thawj "Cov neeg mob ntshav qab zib uas siv verapamil muaj qis dua cov piam thaj, cov ntaub ntawv qhia". Txhais los ntawm Julia Korn, kev yoog – kho ntaub ntawv cov neeg ua haujlwm.