Vozulim-N (Vozulim-N)

1 ml ntawm cov tshuaj muaj:

yam tshuaj: tib neeg insulin (kev tshuaj ntsuam genetic engineering) 100 ME (4.00 mg),

tus zam: protamine sulfate 0.40 mg, zinc oxide 0.032 mg, metacresol 1.60 mg, phenol 0.65 mg, glycerol 16.32 mg, sodium phosphate disubstituted anhydrous 2.08 mg, sodium hydroxide 0.40 mg, hydrochloric acid 0, 00072 ml, dej rau kev txhaj tshuaj txog li 1 ml.

Ib qho kev tshem tawm dawb, uas, thaum sawv ntsug, exfoliates rau hauv cov ntshiab, tsis muaj xim lossis yuav luag tsis muaj xim zoo nkauj thiab muaj cov nag lossis dawb. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co.

Cov Tshuaj Pharmacokinetics

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm txoj kev coj kev tswj hwm (subcutaneously, intramuscularly), qhov chaw tswj hwm (mob plab, ncej puab, pob tw), qhov koob tshuaj (ntim ntawm txhaj tshuaj insulin), cov tshuaj insulin nyob rau hauv cov tshuaj, thiab lwm yam Nws tau faib tsis ncaj ntawm cov ntaub so ntswg thiab tsis hla qhov chaw ntawm lub cev. thiab mus rau hauv niam cov kua mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum (30-80%).

Cev xeeb tub thiab lactation

Tsis muaj kev txwv dab tsi rau kev kho mob ntshav qab zib mellitus nrog cov tshuaj insulin thaum cev xeeb tub, txij li thaum cov tshuaj insulin tsis hla lub cev placental. Thaum npaj kev cev xeeb tub thiab thaum nws, nws yog ib qho tsim nyog yuav tsum tau ua ntu zus ntawm kev kho mob ntshav qab zib. Qhov kev xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab maj mam nce ntxiv hauv qib thib ob thiab thib peb.

Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau. Tsis ntev tom qab yug los, xav tau cov tshuaj insulin sai sai rau qib uas yog ua ntej cev xeeb tub.

Tsis muaj kev txwv rau kev kho mob ntshav qab zib mellitus nrog tshuaj insulin thaum pub niam mis. Txawm li cas los xij, nws yuav tsim nyog los txo cov koob tshuaj insulin, yog li ntawd, kev saib xyuas ceev faj rau ntau lub hlis yog qhov tsim nyog ua ntej tswj kev xav tau kom tau cov tshuaj insulin.

Dosage thiab kev tswj hwm Vozulim-N nyob rau hauv daim ntawv ntawm ncua kev kawm

Cov tshuaj yog npaj rau subcutaneous thawj coj.

Cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm ntawm cov tshuaj yog txiav txim los ntawm tus kws kho mob tshwj xeeb hauv txhua kis, raws li cov concentration ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, cov tshuaj txhua hnub ntawm cov tshuaj yog li 0.5 mus rau 1 IU / kg lub cev qhov hnyav (nyob ntawm tus neeg qhov yam ntxwv ntawm tus neeg mob thiab qhov siab ntawm cov ntshav qab zib).

Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov.

Cov tshuaj feem ntau yog muab tshuaj subcutaneously hauv tus ncej puab. Kev hno tuaj yeem tuaj yeem ua rau hauv pem hauv ntej sab phab ntsa plab, pob tw lossis xub pwg hauv qhov projection ntawm cov nqaij deltoid. Nws yog ib qho tsim nyog yuav tau hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical kom tiv thaiv kev txhim kho ntawm lipodystrophy.

Vozulim-N tuaj yeem muab rau ib leeg lossis ib leeg ua ke nrog luv luv ua yeeb yam insulin (Vozulim-P).

Siv daim cartridge nrog rab mem kua xwb.

Pharmacological pawg

Tso koj saib

Cov Ntaub Ntawv Tam Sim No Xav Tau Index, ‰

Sau npe Cov Tshuaj Tseem Ceeb thiab Tseem Ceeb

Cov ntawv pov thawj rau npe Vozulim-N

• LP-000323

Lub vev xaib raug cai ntawm lub tuam txhab RLS ®. Lub encyclopedia tseem ceeb ntawm cov tshuaj thiab cov khoom muag ntawm cov khw muag tshuaj assortment ntawm Lavxias Internet. Daim ntawv teev cov tshuaj Rlsnet.ru muab cov neeg siv kev nkag mus rau cov lus qhia, tus nqi thiab cov lus piav qhia txog tshuaj, khoom noj khoom haus, khoom siv kho mob, khoom siv kho mob thiab lwm yam khoom lag luam. Daim ntawv qhia pharmacological suav nrog cov ntaub ntawv ntawm kev sib xyaw thiab daim ntawv tso tawm, kev nqis tes ua pharmacological, kev taw qhia rau kev siv, contraindications, kev phiv tshuaj, kev cuam tshuam tshuaj, hom kev siv tshuaj, cov tuam txhab tshuaj. Daim ntawv qhia cov tshuaj muaj nqi rau tshuaj thiab cov khoom lag luam tshuaj hauv Moscow thiab lwm lub nroog Lavxias.

Nws yog txwv tsis pub xa, theej, tshaj tawm cov ntaub ntawv yam tsis tau txais kev tso cai los ntawm RLS-Patent LLC.
Thaum hais cov ntaub ntawv xov xwm luam tawm nyob rau ntawm nplooj ntawv ntawm lub xaib www.rlsnet.ru, qhov txuas mus rau qhov chaw ntawm cov ntaub ntawv xav tau.

Ntau yam nthuav ntxiv

Qoob loo.

Kev ua lag luam siv cov ntaub ntawv tsis raug tso cai.

Cov ntaub ntawv yog npaj rau cov kws kho mob.

Sab sij huam tshuaj

Vim muaj cov ntxim rau cov metabolism hauv carbohydrate: hypoglycemic tej yam kev mob (pallor ntawm daim tawv nqaij, nce tawm hws, palpitations, tshee tshee, tshaib plab, ntxhov siab, mob plab ntawm lub qhov ncauj ntawm lub qhov ntswg, mob taub hau). Kev mob ntshav qog ntshav qis tuaj yeem ua rau txhim kho kev mob hypoglycemic coma.

Kev tsis haum tshuaj: daim tawv nqaij ua pob xoos, Quincke's edema, tsis tshua muaj qhov tshwm sim - kev ua kom tsis nco qab.

Cov tshuaj tiv thaiv hauv zos: hyperemia, o thiab khaus ntawm qhov chaw txhaj tshuaj, nrog rau siv sijhawm ntev - lipodystrophy ntawm thaj chaw txhaj tshuaj.

Lwm yam: o, kev hloov pauv hloov pauv sai (feem ntau thaum pib kho).

Noj ntau dhau

Nrog rau kev siv tshuaj ntau dhau, ua rau lub ntsej muag ntshav qab zib yuav pib ua.

Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov mob ntshav qab zib me me los ntawm kev noj cov suab thaj lossis cov khoom noj uas muaj carbohydrate. Yog li, nws tau pom zoo rau cov neeg mob ntshav qab zib kom nqa cov piam thaj, qab zib, ncuav qab zib lossis kua txiv qab zib nrog lawv.

Thaum muaj mob hnyav, thaum tus neeg mob poob mus rau hauv lub cev, 40%, kev daws teeb meem ntawm dextrose (qabzib) tau txais kev tso ntshav, intramuscularly, subcutaneously, mob ntshav qab zib - glucagon. Tom qab nws rov qab nco qab, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab txhim kho hypoglycemia.

Kev sib txuam

Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj.

Muaj ntau tus yeeb tshuaj uas cuam tshuam rau kev xav tau cov tshuaj insulin.

Kev ua haujlwm hypoglycemic ntawm insulin yog kho dua xim beta-blockers, quinidine, quinine, chloroquine, monoamine oxidase inhibitors, angiotensin converting enzyme inhibitors, carbonic anhydrase inhibitors, octreotide, bromocriptine, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium, tshuaj muaj ethanol.

Hypoglycemic nyhuv ntawm insulin tsis muaj zog glucagon, somatropin, estrogens, tshuaj tiv thaiv lub qhov ncauj, glucocorticosteroids, iodine-muaj cov thyroid hormones, thiazide diuretics, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers, epine blockers; , morphine, phenytoin, nicotine.

Reserpine, salicylates tuaj yeem txhim kho ob qho tib si thiab ua kom tsis muaj zog hypoglycemic ntawm insulin.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Qhov koob tshuaj thiab txoj hauv kev ntawm kev tswj hwm ntawm Vosulima-R yog txiav txim siab ntawm tus kheej hauv txhua kis ntawm cov ntsiab lus ntawm cov piam thaj hauv cov ntshav ua ntej noj mov thiab 1-2 teev tom qab noj mov, thiab tseem nyob ntawm qhov ntsuas ntawm glucosuria thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob.

Cov tshuaj yog muab s / c, hauv / m, hauv / hauv, 15-30 feeb ua ntej noj mov. Feem ntau txoj kev ntawm kev coj ntawm Vosulima-R yog s / c. Nrog cov ketoacidosis uas mob ntshav qab zib, mob ntshav qab zib tsis xeev, thaum phais mob kev cuam tshuam - hauv / thiab / m.

Nrog kev kho mob monotherapy, qhov ntau zaus ntawm kev tswj hwm feem ntau yog 3 zaug hauv ib hnub (yog tias tsim nyog, txog li 5-6 zaug hauv ib hnub), qhov chaw txhaj tshuaj tau hloov pauv txhua lub sijhawm kom tsis txhob muaj kev txhim kho ntawm lipodystrophy (atrophy lossis hypertrophy ntawm subcutaneous rog).

Qhov nruab nrab txhua hnub koob tshuaj yog 30-40 IU, hauv cov menyuam yaus - 8 IU, tom qab ntawd qhov nruab nrab txhua hnub - 0.5-1 IU / kg lossis 30-40 IU 1-3 zaug hauv ib hnub, yog tias tsim nyog - 5-6 zaug ib hnub Cov. Hauv kev noj tshuaj ib hnub dhau ntawm 0.6 U / kg, tshuaj insulin yuav tsum tau txhaj rau 2 lossis ntau dua kev txhaj tshuaj hauv ntau qhov chaw ntawm lub cev. Nws yog qhov ua tau los ua ke nrog insulins ntev-coj.

Cov tshuaj Vozulima-R yog sau los ntawm lub vial los ntawm kev hno nrog cov hno rab koob tsis huv siv roj hmab stopper so tom qab hle lub hau txhuas nrog ethanol.

Pharmacological kev txiav txim

Tib neeg siv tshuaj insulin DNA insulin. Nws yog cov insulin ntawm lub sijhawm ua haujlwm ntev. Regulates ntshav qabzib metabolism, muaj cov teebmeem anabolic. Hauv cov leeg nqaij thiab lwm cov nqaij (muaj qhov tsis suav ntawm lub hlwb), cov roj ntsha insulin thauj cov ntshav qabzib thiab amino acids ntau dua, thiab txhim kho cov protein anabolism. Vosulim-P txhawb nqa kev hloov pauv ntawm cov piam thaj rau glycogen hauv lub siab, inhibits gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj rau cov rog.

Sab sij huam

Los ntawm cov kab ke endocrine: hypoglycemia.

Kev mob ntshav qis heev tuaj yeem ua rau tsis nco qab thiab (tshwj tsis yog kis) tuag.

Ua xua: muaj kev fab rau lub zos yog ua tau - hyperemia, o lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau tso tseg li ntawm ob peb hnub mus rau ntau lub lis piam), kev tiv thaiv kab mob tsis haum (tshwm sim tsawg dua, tab sis muaj dua) - ua pob khaus, ua tsis taus pa, ua pa luv , txo cov ntshav siab, ntshav nce siab, nce hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej.

Cov lus qhia tshwj xeeb

Hloov chaw ntawm tus neeg mob mus rau lwm hom insulin lossis kev npaj tshuaj insulin nrog cov npe lag luam txawv yuav tsum tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj.

Kev hloov pauv ntawm kev ua ub no ntawm insulin, nws hom, hom (kab mob, kab mob tib neeg, insulin ntawm tib neeg cov insulin) lossis cov txheej txheem tsim tawm (DNA recombinant insulin lossis insulin ntawm keeb kwm tsiaj) yuav xav tau kev hloov kho koob tshuaj.

Qhov yuav tsum tau txhaj koob tshuaj Vosulima-R tej zaum yuav tsum tau ua nyob rau thawj zaug kev tswj hwm ntawm tib neeg cov tshuaj insulin tom qab kev npaj tsiaj insulin lossis maj mam dhau ob peb lub lis piam lossis hli tom qab hloov ntaub ntawv.

Txoj kev xav tau cov tshuaj insulin tuaj yeem txo nrog adrenal tsis txaus ua haujlwm, pituitary lossis thyroid caj pas, nrog lub raum lossis hepatic tsis txaus.

Nrog rau qee qhov mob lossis kev ntxhov siab hauv lub siab, qhov xav tau rau insulin yuav nce.

Koob tshuaj yuav tau siv thaum nce ua si lossis thaum pauv noj zaub mov zoo.

Tso tawm daim ntawv, ntim thiab muaj pes tsawg leeg

Kev daws rau kev txhaj tshuaj.

3 ml - cartridges (1) - hlwv pob (1) - pob khoom los ntawm cardboard.
10 ml - iav fwj (1) - thawv ntawv thawv.

Kev noj tshuaj ntxiv

Qhov koob tshuaj thiab txoj hauv kev ntawm kev tswj hwm tshuaj yog txiav txim siab ntawm tus kheej hauv txhua kis raws cov ntsiab lus qabzib hauv cov ntshav ua ntej noj thiab 1-2 teev tom qab noj mov, nrog rau kev kawm tiav ntawm glucosuria thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob.

Raws li txoj cai, s / c muab noj 15-20 feeb ua ntej noj mov. Cov chaw txhaj tshuaj tau hloov pauv txhua zaus. Yog tias tsim nyog, IM lossis IV tswj hwm raug tso cai.

Yuav tuaj yeem ua ke nrog cov insulins ntev ntev.

Sab sij huam

Kev tsis haum tshuaj: urticaria, angioedema, ua npaws, ua tsis taus pa, ua rau muaj ntshav siab.

Los ntawm cov kab mob endocrine: hypoglycemia nrog cov kev ua yeeb yam xws li pallor, nce tawm hws, palpitations, pw tsaug zog, tshee tshee, mob puas siab puas ntsws, cuam tshuam ntawm cov ntshav tiv thaiv kab mob nrog tib neeg cov tshuaj insulin, nce ntxiv ntawm titer ntawm cov tshuaj tiv thaiv insulin nrog kev nce ntxiv ntawm glycemia.

Los ntawm sab ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: cov tsis pom kev tsis pom kev zoo (feem ntau thaum pib kho).

Cov tshuaj tiv thaiv hauv zos: hyperemia, khaus thiab lipodystrophy (mob atrophy lossis hypertrophy ntawm subcutaneous rog) ntawm qhov chaw txhaj tshuaj.

Lwm yam: thaum pib kho, edema yog ua tau (hla nrog kev kho mob txuas ntxiv).

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv qhov kev txo qis hauv qhov xav tau ntawm cov tshuaj insulin hauv thawj peb lub hlis lossis nce ntxiv ntawm zaum ob thiab thib peb. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Thaum lub sijhawm lactation, tus neeg mob xav tau kev soj ntsuam txhua hnub rau ob peb lub hlis (kom txog rau ntawm qhov kev xav tau ntawm insulin).

Yeeb tshuaj sib cuam tshuam

Cov nyhuv hypoglycemic yog txhim kho los ntawm sulfonamides (suav nrog qhov ncauj tshuaj hypoglycemic, sulfonamides), MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (suav nrog salicylides), anabolic (suav nrog stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, lithium npaj, pyridoxine, quinidine, quinine, chloroquin.

Glucagon, GCS, histamine H 1 receptor blockers, tshuaj tiv thaiv qhov ncauj, estrogens, thiazide thiab "voj" diuretics, qeeb calcium calcium blockers, sympathomimetics, thyroid hormones, tricyclic antidepressants, heparin, morphine diazropin txo cov nyhuv hypoglycemic. , tshuaj maj, nicotine, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine tuaj yeem ob leeg txhim kho thiab txo cov nyhuv hypoglycemic ntawm insulin.

Kev siv cov beta-blockers, clonidine, guanethidine lossis reserpine tib lub sijhawm tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib.

Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Nws yog kev ncua rau kev tswj hwm subcutaneous. 1 ml ntawm qhov sib xyaw ua ke muaj soluble tib neeg insulin (70%) thiab insulin-isophan (30%) yog cov tshuaj yeeb dej caw. Tsis tas li, cov tshuaj muaj pes tsawg leeg suav nrog nrog cov khoom sib txuam:

• dej rau kev txhaj tshuaj - 1 ml,
• sodium phosphate (disubstituted dihydrate) - 2.08 mg,
• protamine sulfate - 0.4 mg,
• glycerol - 16.32 mg,
• metacresol - 1,60 mg,
• zinc oxide - 0.032 mg,
• hydrochloric acid - 0,00072 ml,
• sodium hydroxide - 0.4 mg,
• crystalline phenol - 0.65 mg.

Nws yog cov tshuaj dawb, uas thaum lub sijhawm cia yog stratified mus rau hauv lub nag lossis daus dawb thiab tsis muaj xim. Thaum shaken, rov qab rau kev ncua

Cov tshuaj ntim rau hauv cov iav nruab nrab ntawm 10 ml, uas tau muab tso rau hauv lub thawv ntawv thawv.

Hauv nruab nrab - 1200 rubles.

Cov lus qhia rau siv (qauv thiab ntau npaum li cas)

"Vozulim" yog npaj rau kev qhia rau cov rog subcutaneous. Tsuas noj thiab lub sijhawm siv yog txiav txim los ntawm tus kws kho mob mus kawm nyob ntawm qhov ntsuas ntawm cov piam thaj hauv cov ntshav. Feem ntau, cov qauv txhua hnub nws txawv ntawm 0.5 mus rau 1 IU / kg raws tus neeg qhov yam ntxwv ntawm tus neeg mob.

Lub ntsuas kub ntawm qhov tso tawm qhia yuav tsum yog chav kub. Qhov chaw txheem txheem ntawm kev tswj hwm yog subcutaneous rog txheej ntawm ncej puab. Kev txhaj tshuaj rau hauv thaj av ntawm cov nqaij deltoid, sab xub ntiag phab ntsa thiab pob tw tau txais kev tso cai.

TSEEM CEEB Nws yog ib qho yuav tsum tau muab hloov chaw txhaj tshuaj kom tsis txhob muaj lipodystrophy.

Cov neeg mob uas tau los ntawm hom 2 mob ntshav qab zib mellitus tuaj yeem kho nrog Vozulim hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic (siv hauv qhov ncauj), nrog rau kev kho mob monotherapy.

Cawv rau lub peev xwm tsav transp. Wed thiab pluab.

Hauv kev sib txuas nrog lub hom phiaj tseem ceeb ntawm insulin, kev hloov pauv ntawm nws hom lossis nyob ntawm qhov tseem ceeb ntawm lub cev lossis lub hlwb kev ntxhov siab, nws muaj peev xwm txo qis kev muaj peev xwm tsav lub tsheb lossis tswj ntau cov txheej txheem, nrog rau koom nrog rau lwm cov dej num txaus ntshai uas xav tau kev nce siab thiab nrawm ntawm lub hlwb thiab lub cev kev xav.