Humulin® M3 (Humulin® M3)

Pauv lub npe ntawm qhov kev npaj: HUMULIN ® Ib txwm muaj

Lub Npe Tsis Muaj Feem Uas Npe (INN):
Soluble insulin (tib neeg kev tsim kho tshuab)

Dosage daim ntawv
Kev daws rau kev txhaj tshuaj

Muaj pes tsawg leeg
1 ml muaj:
cov tshuaj heev - tib neeg cov insulin 100 IU / ml,
tus zam: metacresol, glycerol (glycerin), dej rau txhaj, hydrochloric acid tov 10% thiab / lossis sodium hydroxide tov 10% tuaj yeem siv rau hauv kev tsim khoom los tsim cov pH.

Kev piav qhia
Cov xim tsis muaj pob tshab.

Cov tshuaj pab pawg kho mob
Tus neeg sawv cev hypoglycemic yog luv luv ua yeeb yam insulin.

ATX Cov Cai A10AB01.

Cov chaw muag tshuaj
Cov Tshuaj Hauv Tshuaj
Humulin ® Li niaj zaus yog tib neeg cov tshuaj tua kab mob DNA insulin. Kev ua haujlwm tseem ceeb ntawm insulin yog kev cai ntawm cov metabolism hauv qabzib. Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg ntawm lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.
Humulin ® Li niaj zaus yog kev npaj insulin luv luv. Qhov pib ntawm kev ua ntawm cov tshuaj yog 30 feeb tom qab kev tswj hwm, qhov ua haujlwm siab tshaj plaws ntawm 1 thiab 3 teev, lub sijhawm ua haujlwm yog 5-7 teev. Cov tib neeg sib txawv hauv cov dej num hauv insulin yog nyob ntawm qee yam xws li koob tshuaj, xaiv chaw txhaj tshuaj, kev qoj ib ce ntawm tus neeg mob, thiab lwm yam.

Cov Tshuaj Pharmacokinetics
Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm cov tshuaj insulin), cov tshuaj insulin nyob rau hauv cov tshuaj, thiab lwm yam Nws muab faib tsis ncaj ntawm cov ntaub so ntswg, thiab tsis nkag rau hauv qhov chaw tiv thaiv thiab nkag mus rau niam mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum (30-80%).

Nosological kev faib tawm (ICD-10)

Tsuas tshuaj thiab tswj hwm

S / c rau xwb pwg, ncej puab, pob tw los sis plab. Kev tso cai intramuscular yog tso cai.

Qhov koob tshuaj Humulin ® M3 yog txiav txim los ntawm tus kws kho mob ib leeg zuj zus, nyob ntawm seb cov concentration ntawm cov piam thaj hauv cov ntshav. Hauv / hauv kev qhia tawm ntawm cov tshuaj Humulin M3 yog contraindicated.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj li ib hlis ib zaug. Nrog s / c tswj hwm cov tshuaj insulin, kev saib xyuas yuav tsum tau ceev faj kom tsis txhob nkag rau cov hlab ntshav. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Cov neeg mob yuav tsum tau kawm paub txog kev siv tshuaj insulin kom zoo.

Humulin ® M3 yog qhov npaj sib xyaw ua ke nrog cov ntsiab lus tshwj xeeb ntawm Humulin ® Li niaj zaus thiab Humulin ® NPH, npaj kom tsis txhob muaj qhov sib xyaw nrog kev npaj tshuaj insulin los ntawm cov neeg mob lawv tus kheej. Qhov tseeb ntawm kev muab tshuaj insulin yog tus kheej.

Npaj rau kev qhia

Rau qhov npaj Humulin ® M3 hauv vials. Tam sim ntawd ua ntej siv, cov vials ntawm Humulin ® M3 yuav tsum tau muab sib dhos ntawm xib teg ob peb zaug kom txog thaum cov tshuaj insulin rov qab ua tiav kom txog thaum nws dhau los ua kua dej lossis kua mis. Tsis txhob co khov kho, raws li qhov no tuaj yeem ua rau npuas dej, uas tuaj yeem cuam tshuam nrog cov koob tshuaj kom raug. Tsis txhob siv tshuaj insulin yog tias nws muaj plaub ya ri tom qab sib tov los yog cov khoom sib xyaw dawb dawb txuam rau hauv qab lossis phab ntsa ntawm lub thawb, tsim cov nyhuv ntawm ib qho qauv khov. Siv cov tshuaj insulin uas phim cov tshuaj insulin txhaj tshuaj.

Txog rau kev npaj Humulin ® M3 hauv daim cartridges. Ua ntej yuav siv, Humulin ® M3 daim cartridges yuav tsum tau muab nruab nrab ntawm lub xib teg kaum npaug thiab tshee, tig 180 ° kuj kaum zaus kom txog thaum cov tshuaj insulin rov qab ua tiav kom txog thaum nws dhau los ua kua dej tsis zoo lossis kua mis. Tsis txhob co khov kho, raws li qhov no tuaj yeem ua rau npuas dej, uas tuaj yeem cuam tshuam nrog cov koob tshuaj kom raug. Sab hauv txhua daim laub ntawv yog lub khob me me uas yooj yim tov cov tshuaj insulin. Tsis txhob siv tshuaj insulin yog tias nws muaj plaub ya ri tom qab tov. Cov cuab yeej ntawm cov cartridges tsis pub sib xyaw lawv cov ntsiab lus nrog lwm cov insulins ncaj qha hauv daim cartridge nws tus kheej. Cartridges tsis yog yuav tsum kom thim rov qab. Ua ntej kev txhaj tshuaj, nws yog ib qho tsim nyog yuav tau paub koj tus kheej nrog cov kws tsim khoom cov lus qhia rau kev siv cov koob txhaj tshuaj rau kev tswj cov tshuaj insulin.

Rau Humulin ® M3 hauv QuickPen ™ Syringe Cwj mem. Ua ntej kev txhaj tshuaj, koj yuav tsum nyeem QuickPen ™ Syringe Pen Cov Lus Qhia rau Siv.

QuickPen ™ Daim duab qhia txog cwj mem

QuickPen ™ syringe cwj mem tau yooj yim siv. Nws yog cov cuab yeej siv los tswj cov tshuaj insulin ("tus cwj mem kua") muaj 3 ml (300 PIECES) ntawm kev npaj tshuaj insulin nrog ib qho dej ntawm 100 IU / ml. Koj tuaj yeem nkag los ntawm 1 txog 60 units ntawm cov tshuaj insulin rau ib zaug kev txhaj tshuaj. Koj tuaj yeem tsim koob tshuaj nrog qhov tseeb ntawm ib chav. Yog tias ntau cov koog tau tsim tsa, cov koob tshuaj tuaj yeem hloov kho uas tsis muaj qhov poob ntawm insulin. QuickPen ™ Syringe Cwj mem yog pom zoo siv nrog koob ntau lawm Becton, Dickinson thiab Tuam Txhab (BD) rau koob txhaj tshuaj. Ua ntej siv cov koob txhaj syringe, nco ntsoov tias rab koob tau txuas nrog lub xias nqus.

Yav tom ntej, cov cai hauv qab no yuav tsum tau ua.

1. Ua raws li kev cai ntawm asepsis thiab tshuaj tua kab mob uas koj tus kws kho mob pom zoo.

3. Xaiv qhov chaw rau kev txhaj tshuaj.

4. Ua kom tawv nqaij rau ntawm thaj chaw txhaj tshuaj.

5. Lwm qhov chaw txhaj tshuaj kom qhov chaw qub siv tsis ntau tshaj li ib zaug ib hlis.

QuickPen ™ syringe Cwj mem Kev Npaj thiab Kev Taw Qhia

1. Rub lub hau tshuaj qhwv kom txav nws. Tsis txhob kiv taub hau. Tsis txhob rub daim ntawv lo los ntawm cov xaum xim. Nco ntsoov tias tshuaj insulin rau hom tshuaj insulin, hnub tas sij hawm, tsos mob. Maj mam muab cov ntawv txhaj tshuaj xoob 10 zaug ntawm xib teg thiab tig dua 10 zaug.

2. Noj ib rab koob tshiab. Tshem tawm daim ntawv nplaum ntawm lub hau ntxiv ntawm rab koob. Siv cov cawv pas cawv mus so lub roj hmab disc tom kawg ntawm lub taub hau cartridge. Txuas lub rab koob nyob rau hauv lub hau, axially, mus rau syringe cwj mem. Cov ntsia hlau ntawm rab koob kom txog thaum siab txuas.

3. Tshem tawm ntawm sab nraud ntawm rab koob. Tsis txhob muab pov tseg. Tshem lub hau ntawm lub hau thiab muab pov tseg.

4. Kuaj xyuas QuickPen ™ Syringe cwj mem rau tshuaj insulin. Txhua zaus koj yuav tsum xyuas cov tshuaj insulin. Kev kuaj xyuas cov tshuaj insulin xa tawm los ntawm rab koob txhaj tshuaj yuav tsum tau ua ua ntej txhua qhov kev txhaj tshuaj kom txog thaum lub qhov ncauj me me ntawm insulin tshwm sim kom paub tseeb tias cov kua mem yog npaj rau cov koob tshuaj.

Yog tias koj tsis kuaj xyuas cov tshuaj insulin ua ntej qhov trickle tshwm, koj tuaj yeem tau txais insulin ntau dhau lossis ntau dhau.

5. Kho cov tawv nqaij los ntawm rub nws los yog khaws nws hauv qhov loj. Siv rab koob scing siv qhov txheej txheem txhaj tshuaj uas koj tus kws kho mob pom zoo. Tso koj tus ntiv tes xoo rau ntawm lub koob tshuaj thiab nias kom ruaj khov kom txog thaum nws nres kiag li. Txhawm rau nkag mus rau tag nrho cov tshuaj, tuav lub koob tshuaj thiab maj mam suav rau 5.

6. Tshem tawm rab koob thiab maj mam nyem qhov chaw txhaj tshuaj nrog paj rwb pas nrig rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj. Yog tias cov tshuaj insulin tawm los ntawm rab koob, feem ntau tus neeg mob tsis tuav rab koob nyob hauv qab daim tawv nqaij ntev ntev. Lub xub ntiag ntawm kev poob ntawm insulin ntawm qhov taub ntawm qhov koob yog qhov qub, nws yuav tsis cuam tshuam rau koob tshuaj.

7. Kev siv rab koob rab koob, tshem tawm rab koob thiab pov tseg ntawm nws.

Txawm hais tias cov lej raug luam tawm nyob rau hauv lub koob taw qhia qhov rai ua tus lej, tus lej khib raws li txoj kab ncaj nruab nrab ntawm tus lej.

Yog tias cov koob tshuaj uas yuav tsum tau ua rau kev tswj hwm ntau dua li ntawm cov lej uas tseem tshuav hauv daim cartridge, koj tuaj yeem nkag mus ntxiv cov tshuaj insulin hauv daim ntawv txhaj tshuaj no thiab tom qab ntawd siv tus cwj mem tshiab los ua kom tiav kev tswj hwm ntawm cov koob xav tau, lossis nkag mus rau tag nrho cov koob tshuaj uas siv tus cwj mem tshiab.

Tsis txhob sim txhaj tshuaj insulin los ntawm kev hloov lub pob tshuaj. Tus neeg mob yuav tsis tau txais tshuaj insulin yog tias nws hloov lub pob tshuaj. Koj yuav tsum nyem rau ntawm lub khawm koob tshuaj hauv txoj kab ncaj ncaj txhawm rau kom tau txais cov koob tshuaj ntawm cov tshuaj insulin.

Tsis txhob sim hloov cov tshuaj ntawm cov tshuaj insulin thaum txhaj tshuaj.

Lus khaws xav Lub taub ntim koob txhaj tshuaj yuav tsis pub tus neeg mob teeb tsa koob tshuaj insulin nyob rau hauv kev dhau ntawm cov chav nyob hauv daim ntawv xaum npias. Yog tias koj tsis paub meej tias koob tshuaj tiv thaiv tag nrho siv tau, koj yuav tsum tsis txhob nkag rau lwm tus. Nws yog ib qho tsim nyog yuav tau tshem tawm rab koob tom qab txhua txoj kev txhaj tshuaj. Koj yuav tsum nyeem thiab ua raws li cov lus qhia muaj nyob hauv cov lus qhia rau kev siv tshuaj. Nws yog ib qho tsim nyog yuav tsum kuaj cov ntawv lo rau ntawm rab koob txhaj tshuaj ua ntej txhua qhov kev txhaj tshuaj, kom paub tseeb tias hnub tas sij hawm ntawm cov tshuaj tsis tau tas sij hawm thiab tus neeg mob tau siv hom tshuaj insulin tsis raug, tsis txhob tshem daim ntawv lo los ntawm tus cwj mem syringe.

Cov xim ntawm QuickPick ™ syringe cwj mem koob khawm sib raug rau cov xim ntawm pob txaij ntawm daim duab lo tus xaum xaj thiab nyob ntawm hom insulin. Hauv phau ntawv no, khawm koob tshuaj yog grayed tawm. Beige xim ntawm QuickPen ™ syringe cwj mem lub cev qhia tau tias nws yog tsim rau siv nrog Humulin ® khoom.

Cia thiab pov tseg

Tus cwj mem tsis tuaj yeem siv yog tias nws tau nyob sab nraum lub tub yees rau ntau tshaj li lub sijhawm teev tseg hauv cov lus qhia rau siv.

Tsis txhob muab xaum xaum hluav taws xob nrog rab koob txuas rau nws. Yog tias rab koob raug tso rau hauv qhov txuas, cov insulin tuaj yeem tawm ntawm tus cwj mem, lossis insulin yuav qhuav hauv rab koob, yog li txhaws lub koob, lossis cua npuas tuaj yeem tsim nyob rau hauv lub taub hau.

Cov koob txhaj tshuaj uas siv uas tsis siv yuav tsum muab cia rau hauv tub yees ntawm qhov txias ntawm 2 txog 8 ° C. Tsis txhob siv cov xwj xem hluav taws xob yog tias nws tau khov.

Tus cwj mem kua siv tam sim no yuav tsum khaws cia hauv chav sov, hauv qhov chaw tiv thaiv los ntawm tshav kub thiab lub teeb, tsis ncav cuag cov menyuam yaus.

Muab cov koob txhaj tshuaj siv rau hauv cov ntaub ntawv pov thawj-pov thawj, cov ntim rov qab (piv txwv li, lub ntim rau cov khoom siv tshuaj lom neeg lossis khib nyiab), lossis raws li kev pom zoo los ntawm koj tus kws kho mob.

Muab cov ntawv uas siv cov kua tshuaj phwj uas tsis muaj koob los txuas rau lawv raws li cov lus pom zoo ntawm tus kws kho mob tuaj ua raws li cov khoom pov tseg kho mob hauv nroog.

Tsis txhob ntim cov thawv ntim khoom ntim rau hauv.

Daim ntawv tso tawm

Ncua rau lub subcutaneous thawj coj, 100 IU / ml. 10 ml ntawm cov tshuaj nyob rau hauv nruab nrab iav vials. 1 fl. muab ntim rau hauv cov thawv ntawv los qhia.

3 ml txhua nyob rau hauv lub nruab nrab iav cartridge. 5 daim laub muab tso rau hauv lub hlwv. 1 bl. lawv muab tso rau hauv cov thawv ntawv thawv los yog daim cartridge tau tso rau hauv QuickPen-syringe mem. 5 Cov phwj ntim taub hau yog muab tso rau hauv cov thawv ntawv thawv.

Chaw tsim tshuaj paus

Tsim los ntawm: Eli Lilly thiab Tuam Txhab, USA. Lilly Lub Chaw Muag Khoom, Indianapolis, Indiana 46285, Asmeskas.

Pob: ZAO "ORTAT", 157092, Russia, Kostroma cheeb tsam, Susaninsky koog tsev kawm ntawv, s. Qaum Qaum teb, microdistrict. Kharitonovo.

Cartridges, QuickPen ™ syringe Cwjmem , tsim los ntawm Lilly Fabkis, Fabkis. Cheeb Tsam Industrialiel, 2 ru Colonel Lilly, 67640 Fegersheim, Fab Kis.

Pob: ZAO "ORTAT", 157092, Russia, Kostroma cheeb tsam, Susaninsky koog tsev kawm ntawv, s. Qaum Qaum teb, microdistrict. Kharitonovo.

Lilly Pharma LLC yog tus tsim tshwj xeeb rau Humulin ® M3 hauv Lavxias Federation

Pharmacological kev txiav txim

Tib neeg siv tshuaj insulin DNA insulin. Nws yog kev ua haujlwm nruab nrab insulin.
Lub txiaj ntsig tseem ceeb ntawm cov tshuaj yog kev tswj hwm ntawm cov metabolism hauv qab ntuj. Tsis tas li ntawd, nws muaj qhov ua kom anabolic. Hauv cov leeg nqaij thiab lwm cov nqaij (tshwj tsis yog lub hlwb), cov roj ntsha insulin ua rau thauj cov ntshav qabzib thiab amino acids nrawm nrawm, ua kom muaj protein ntau anabolism. Insulin txhawb kev hloov pauv ntawm cov piam thaj rau glycogen hauv lub siab, inhibits gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj rau cov rog.

Sab sij huam

- Ib qhov tshwm sim cuam tshuam nrog cov nyhuv tseem ceeb ntawm cov tshuaj: hypoglycemia.
- Mob ntshav qab zib heev tuaj yeem ua rau tsis nco qab thiab (tshwj tsis yog kis) kom tuag.
- Kev tsis haum tshuaj: kev fab tshuaj nyob rau hauv zos yog ua tau - hyperemia, o lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau nres li ntawm ob peb hnub mus rau ntau lub lis piam), kev tiv thaiv kab mob tsis haum (tshwm sim tsawg dua, tab sis muaj dua) - ua pob khaus, ua tsis taus pa, txog siav ua tsis taus pa, txo cov ntshav siab, txhawb lub plawv dhia, tawm hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej.
- Lwm yam: qhov ntxim nyiam ntawm kev txhim kho lipodystrophy tsawg heev.

Dosage daim ntawv

Ncua rau kev txhaj tshuaj 100 IU / ml

Ib ml ntawm kev ncua kev kawm muaj

cov tshuaj nquag - tib neeg cov insulin (DNA - recombinant) 100 IU,

zam txim: distilled metacresol, glycerin, phenol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide (hais txog zinc Zn ++), hydrochloric acid 10% txhawm rau kho pH, sodium hydroxide 10% kev kho kom hloov pH, dej rau kev txhaj tshuaj.

Ib qho kev tshem tawm dawb, uas, thaum sawv ntsug, exfoliates rau hauv cov ntshiab, tsis muaj xim lossis yuav luag tsis muaj xim zoo nkauj thiab muaj cov nag lossis dawb. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Humulin® M3 yog ib qho nruab nrab ua yeeb yam insulin. Qhov pib ntawm kev ua ntawm cov tshuaj yog 30 feeb tom qab kev tswj hwm, qhov ua haujlwm siab tshaj plaws yog nruab nrab ntawm 1 txog 8.5 teev, sijhawm ua haujlwm yog 14-15 teev.

Daim ntawv qhia txog cov haujlwm (cov piam thaj saum-kev nkhaus) tom qab kev tswj hwm ntawm txoj haujlwm yog qhia ua kab loj hauv daim duab hauv qab no. Cov kev sib txawv hauv cov tshuaj insulin sib txawv raws li yam tseem ceeb xws li koob tshuaj, xaiv chaw txhaj tshuaj, kev qoj ib ce ntawm tus neeg mob, thiab lwm yam

Kev siv tshuaj insulin

Sijhawm (teev)

Cov Tshuaj Hauv Tshuaj

Humulin M3 yog DNA tso tawm tib neeg cov kua dej. Nws yog ob-ncua kev ncua rau kev txhaj tshuaj (30% Humulin Х Li niaj zaus thiab 70% Humulin NPH).

Kev ua haujlwm tseem ceeb ntawm insulin yog kev cai ntawm cov metabolism hauv qabzib.

Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.