Qhov cuam tshuam ntawm kev siv lub sijhawm ntev ntawm sibutramine

Qhov sib txawv yog qhov pom ntawm metformin hauv cov ntsiav tshuaj, uas muaj suab thaj txo thiab rog ua cov rog.

Yog li, cov tshuaj yog kws kho nyob rau hauv kev kho kev rog, lub nra hnyav ntshav qab zib.

Cov khoom pheej yig hloov rau reduxin.

Cov tshuaj phiv yog linoleic acid, uas ua tiav txo cov txheej txheem ua kom muaj roj.

Raws li kev txheeb xyuas ntawm kev poob phaus, cov tshuaj no nquag txo kev qab los noj mov, thiab poob phaus sai dua.

Nws yog qhov zoo tshaj plaws analogue ntawm reduxin los ntawm cov chaw tsim khoom hauv tsev.

Daim ntawv tso tawm - ntsiav tshuaj, tshuaj ntsiav, cream, cocktails, tuav, phoov, teas, granules, zom khoom qab zib.

Pheej yig kaw zoo hloov rau reduxin teeb.

Raws li daim ntawv thov ntawm cov tuam ntxhab, turboslim txhim kho txoj hlab hlwb, txhim kho txoj kev zom, thiab txhim kho kev tiv thaiv kab mob.

Ukrainian hloov pauv

Ntawm cov tshuaj ntawm Ukrainian ntau lawm, koj tuaj yeem nrhiav pom cov tshuaj uas yuav pab teb cov lus nug ntawm dab tsi los hloov reduxin nrog.

• Styfimol Cov. Daim ntawv tso tawm - tsiav tshuaj. Cov ntsiav tshuaj tseem ceeb yog Garcinia Cambogia Extract, uas tau paub ntev los rau nws txoj haujlwm kev noj haus. Kev noj cov tshuaj txo cov roj (cholesterol), txo qis, qab los noj mov, thiab tswj kav dej qabzib. Tus nqi nruab nrab yog 560-750 rubles.

Belarusian generics

Lub rooj muaj cov npe ntawm Belarusian generic reduxin, uas nquag siv hauv kev kho mob rog, lossis hauv ib pob ntawm kev ntsuas kom poob ceeb thawj.

Lwm cov lus piv txwv txawv teb chaws

Cov khoom lag luam niaj hnub coj los sib piv ntawm cov tshuaj reduxin tuaj yeem nrhiav tau hauv cov tshuaj pheej yig dua, nrog rau cov tshuaj muaj nqi ntau. Xav txog qhov zoo tshaj plaws ntawm lawv.

• Lindax Cov. Anorexigenic tshuaj tsim los txhim kho qhov kev xav ntawm tag nrho. Lub teb chaws ntawm keeb kwm - Czech koom pheej. Tus nqi nruab nrab yog 1700-6800 rubles.
• Ntxim Nyias Cov. Cov tshuaj yog tsim hauv Is Nrias teb. Cov khoom pheej yig tshaj plaws ntawm analog ntawm reduxin. Nws yog tsim raws ntawm sibutramine thiab muaj nyob hauv tsiav tshuaj. Nws tsuas yog siv rau cov hom phiaj kho mob hauv kev kho mob rog. Tus nqi nruab nrab yog 140-350 rubles.
• Meridia Cov. Cov tshuaj kom txo qhov hnyav hauv lub cev, ua raws li kev tswj hwm ntawm qab los noj mov. Lub teb chaws ntawm keeb kwm - Lub teb chaws Yelemees. Tus nqi nruab nrab yog 2500–3500 rubles.
• Zelix Cov. Kev kho mob rau kev rog. Lub teb chaws ntawm keeb kwm - Poland. Tus nqi nruab nrab yog 1800-2500 rubles.
• Duav Cov. Cov khoom muaj nyob rau hauv daim ntawv ntawm cov tsiav tshuaj. Nws zwm rau ib pawg ntawm anorexigens. Lub teb chaws ntawm keeb kwm - Is Nrias teb. Tus nqi nruab nrab yog 780-950 rubles.

Sibutramine thiab nws cov analogues yog cov tshuaj muaj zog psychotropic zoo uas tuaj yeem tiv thaiv lub hauv nruab nrab lub paj hlwb. Ua rau muaj txiaj ntsig narcotic, cov ntsiav tshuaj no tuaj yeem ua rau kev tos cov neeg mob.

Muaj cov piv txwv ntawm kev tuag tom qab ib qho kev ywj pheej ntawm cov tshuaj no nyob rau hauv kev txiav txim kom tau tshem ntawm "tshaj" qhov hnyav.

Thov nco ntsoov tias noj cov tshuaj anorexigen nrog lub ntsej muag zoo nkauj lub cev qhov hnyav yog txwv tsis pub. Cov tshuaj rog rog tsuas yog siv los kho kev rog, nruj me ntsis raws li kws kho mob cov lus qhia.

Sibutramine tau raug tsim tawm thaum chiv thawj coj los siv ua kev daws teeb meem rau kev nyuaj siab, tab sis hmoov tsis, nws tsis tau txais qhov tshwm sim zoo. Tab sis thaum qhov kev sim, nws lub peev xwm ua rau nws tsis qab los noj mov tau pom. Txij thaum ntawd, sibutramine tau siv los ua. Muaj ntau lub tebchaws uas txwv tsis pub muag cov tshuaj. Yog li ntawd, kev xa mus rau cov teb chaws CIS tau raug muab ncua tseg.

Kev siv cov tshuaj muaj feem cuam nyob rau hauv rooj plaub thaum lwm txoj hauv kev rau qhov poob phaus tsis muab cov nyhuv. Sibutramine nyiam dua yog siv nrog kev noj zaub mov noj lossis ua kom lub cev qoj ib ce. Yog li nws yuav coj ntau dua:

• Npub qab los noj mov
• Nquag tawg los ntawm lub cev rog,
• Kev ua kom muaj ntau lawm ntawm serotonin, uas pab ua kom zoo mloog,
• Txo txo ​​salivation thiab lub peev xwm los tsim caries,
• Kev muaj txiaj ntsig zoo, kev poob phaus ntawm 7 txog 15 kg ib hlis.

Nws muaj hom tshuaj dab tsi?

Muaj ntau cov tshuaj uas muaj cov sibutramine, ntawm no yog qee yam ntawm lawv:

• Meridia (German ntau lawm),
• Lindaksa (Czech ntau lawm),
• Reduxin (ntau lawm ntawm Russia),
• , Sliema (ntau lawm ntawm Is Nrias teb).

Tag nrho cov tshuaj no muaj cov sibutramine thiab lwm cov tshuaj tiv thaiv kab mob. Sibutramine tseem muaj cov tshuaj analogues, lawv kuj nyiam txo qhov hnyav, tab sis lawv cov nyhuv ntawm lub cev yog softer thiab tsis txaus ntshai. Cov ntsiav tshuaj zoo sib xws: denfluramine, dexfenfluramine, lorcaserin. Ntawm cov analogues yog cov tshuaj uas inhibit reuptake ntawm serotonin.

Noj ntau dhau

Cov tsos mob: nce zuj zus ntawm phiv. Qhov tshwj xeeb tshaj yog cov ntshav siab, lub plawv dhia, mob taub hau thiab kiv taub hau. Qhov no tuaj yeem tshwm sim ob qho tib si los ntawm kev haus yuam kev dhau los, thiab los ntawm ib qho tshwj xeeb.

Kev kho ntau tshaj: hu rau kws kho mob, uas nyob rau hauv lem yuav sau ntawv kho mob kub ceev kom txog thaum kuaj tau meej.

Thov

Cov lus qhia Sibutramine rau kev siv. Kev muab tshuaj thawj zaug yuav tsum tsis pub tshaj 10 mg rau ib hnub. Yog tias cov tshuaj muaj nyob hauv cov tshuaj ntsiav, tom qab ntawd cov tshuaj ntsiav yuav tsum tau noj thaum sawv ntxov nrog qhov muaj dej ntau. Yog tias ib zaug ploj lawm, tom qab ntawd tsis txhob txhaj tshuaj ntxiv ob zaug ntxiv. Yog tias tsis muaj qhov tshwm sim ntawm kev siv tshuaj li ntawd ib hlis, tom qab ntawd koj tuaj yeem nce lub koob tshuaj rau 15 mg rau ib hnub, tab sis tsis pub tshaj. Tab sis tsuas yog nrog zoo tiv thaiv ntawm cov tshuaj.

Txog rau sijhawm haus cov sibutramine, cov kev xav txawv ntawm no. Tab sis koj yuav tsum tsis txhob noj nws ntev dua ib xyoos, vim tias tsis muaj kev ntseeg siab txog kev nyab xeeb thiab muaj txiaj ntsig ntawm cov tshuaj rau lub sijhawm ntev dua. Yog tias tsis muaj qhov tshwj xeeb zoo hauv kev txo lub cev qhov hnyav tsawg kawg 5% ntawm qhov hnyav hauv thawj peb lub hlis ntawm kev siv, tom qab ntawd koj yuav tsum tsum tsis txhob noj cov tshuaj.

Kev tiv thaiv kev nyab xeeb

Nws yuav tsum nkag siab tias cov tshuaj yuav nqa cov txiaj ntsig zoo tsuas yog ua ke nrog kev noj haus. Thaum lees txais cov khoom no, koj yuav tsum tau ua raws li ntau txoj cai, los ntawm kev saib xyuas uas koj tuaj yeem zam qhov tsis zoo tsis txaus ntseeg.

Ntawm no yog qhov tseem ceeb:

• Tsav tsheb
• Siv tib lub sijhawm sibutramine thiab lwm yam tshuaj anorexigenic,
• Tsis txhob haus dej haus cawv nrog sibutramine,
• Muaj hnub nyoog tom qab 65 xyoo.

Nws tsis pom zoo kom noj sibutramine thaum cev xeeb tub thiab lactation, vim tias kev tshawb fawb tsis tau tshawb nrhiav. Nws kuj tsis paub meej tias cov tshuaj thiab nws cov tshuaj metabolic kis mus rau leej niam mis li cas.

Sibutramine yog yeeb tshuaj muaj zog uas muaj nws qhov zoo thiab kev pom zoo. Thaum txiav txim siab cov kev poob phaus nrog cov tshuaj raws li sibutramine, nco ntsoov sab laj nrog tus kws kho mob, nyeem cov lus qhia rau kev siv thiab coj mus rau hauv kev txheeb xyuas ntawm cov neeg uas tau siv cov nyiaj no. Pib zoo nrog kev noj haus, kev ua kis las. Hauv ntau qhov xwm txheej, muaj cov khoom noj muaj roj uas ua rau lub plab zom mov, tab sis muaj kev phom sij ntau dua.

Koj lub tswv yim ntawm tsab xov xwm:

Tshuaj Sibutramine siv los ua kev pabcuam hauv kev sib ntaus cov tiv thaiv kev rog. Cov tshuaj yog siv ua ke nrog kev tswj kom zoo thiab ua kom lub cev muaj zog. Sibutramine pom tsuas yog qhia rau cov neeg mob uas muaj lub cev ua kom tawm ntawm lub cev (BMI) tsawg kawg 30 thiab cov neeg mob uas muaj BMI ntau dua 27 thiab muaj feem cuam tshuam xws li mob ntshav qab zib lossis ntshav siab.

Sibutramine: cov ntaub ntawv muaj kev phom sij

Nrog kev sib kis ntawm sibutramine hauv Asmeskas thiab Europe, muaj ntau qhov pov thawj pom tias kev noj tshuaj pab noj haus raws li nws ua rau muaj qhov nce ntxiv ntawm kev tua tus kheej, mob plawv thiab mob hlab ntsha, ntau ntawm nws cov neeg siv khoom "zaum" ntawm sibutramine.

Qhov no yuam cov tuam ntxhab kom tshawb fawb tag nrho sibutramine thiab txwv tsis pub nws muag, suav nrog sibutramine rau ib pawg muaj hwj chim psychotropics zoo ib yam li cov pa tshuaj.

Hauv kev cai lij choj Lavxias, sibutramine thiab nws cov analogues raug muab rau cov pab pawg uas muaj yeeb tshuaj zoo thiab nws raug txwv tsis pub muag rau lawv yam tsis muaj kws kho mob tshwj xeeb.Qhov tshwj tsis yog cov neeg muaj kev paub txog kev rog thiab tsis muaj peev xwm siv tau lwm txoj kev, tsis muaj kev phom sij los txo lub cev qhov hnyav.

Rau leej twg sibutramine yog contraindicated

Hauv feem ntau ntawm cov lus piav qhia ntawm cov tshuaj uas muaj cov sibutramine, tsis muaj qhov qhia paub (lossis lawv tsis tshua muaj neeg tsawg thiab ua tsis tiav) ntawm kev phiv thiab contraindications. Cov lag luam zais cia, vim tias qhov no yuav cuam tshuam loj rau kev muag tshuaj uas muaj sibutramine.

Txawm li cas los xij, daim ntawv teev npe ntawm contraindications yog qhov dav heev. Cov no suav nrog:

• kab mob hauv lub plawv thiab kho ntshav (ntshav siab, mob plawv, mob plawv)
• cerebrovascular kev huam yuaj,
• kev mob hlwb thiab neurological nrog bulimia lossis tsis nco qab,
• mob siab los yog mob raum
• txhaws tsis meej
• cov kab mob qhov muag (kab mob ntsej muag, myopia),
• mob vwm, mob huam.

Tsis tas li ntawd, sibutramine txwv tsis pub siv ua ke nrog ntau yam tshuaj - siv yeeb tshuaj rau kev kho mob ntawm cov hlab ntshav tshuaj, tshuaj tua kab mob, tshuaj uas cuam tshuam rau cov ntshav coagulation.

Cov tshuaj tsis sib xws nrog cawv, nws yog txwv tsis pub noj thaum cev xeeb tub thiab lactation, muaj hnub nyoog qis dua 18 xyoo thiab tom qab 60 xyoo. Thiab cov kev txwv thiab kev txwv tsis xaus rau ntawd.

Sibutramine: qhov tsis zoo

Tom qab noj sibutramine, muaj ntau yam tsis zoo. Ua ntej tshaj plaws, kev siv cov tshuaj raws cov tshuaj no muab ib txoj kev xav zoo sib xws ntawm kev tos. Thaum koj tso tseg nws tej zaum yuav tshwm sim:

• insomnia ua tau zoo zuj zus thaum nws raug coj mus,
• txob taus, nyiam tua tus kheej,
• kiv tob hau, mob taub hau,
• siab surges, tsis muaj zog.

Cov teeb meem loj dua, xeev siab thiab ntuav, ntuav, mob hauv siab, plooj tsis pom kev, mob nraub qaum, ua pa nyuaj, tsis meej pem, mob plab zom mov, tsis nco qab, ua kom sib deev, ntxiv lawm tshob, teeb meem tawv nqaij tuaj yeem tshwm sim.

Thiab qhov no tsis yog txhua yam tsis zoo ntawm kev noj sibutramine. Tsis muaj tsawg tshaj qhov tseem ceeb yog qhov tseeb tias thaum kev sim rau cov tsiaj, pom tau zoo teratogenic nyhuv ntawm sibutramine tau pom, ua rau cov me nyuam hauv plab tsis zoo.

Cov txheej txheem ntawm kev poob ceeb thawj yog qhov nyuaj tias txhua ntu txhais tau tias hauv nws ua tau zoo. Qhov no kuj siv rau cov tshuaj. Sibutramine thiab nws cov analogues tsim nyog tshwj xeeb kev hwm ntawm cov neeg uas poob ceeb thawj. Cov khoom no tau raug xa mus rau yav dhau los ntawm thaj chaw ntawm Lavxias thiab tau muag los ntawm cov ntawv sau tshuaj, raws li qhia meej los ntawm cov lus qhia rau kev siv Sibutramine. Tab sis tam sim no, hauv khw muag tshuaj, tsis tuaj yeem nrhiav ib cov tshuaj muaj npe no. Tsuas muaj nws cov analogues uas muaj sibutramine uas yog cov tshuaj nquag.

Nws yog cov tshuaj tiv thaiv kev ntxhov siab uas cov qauv ntawm sibutramine hydrochloride monohydrate ntsev tau tsim. Nws cov khoom sib txuas tau ua los ntawm Asmeskas cov kws tshawb fawb. Thaum lub sij hawm sim tshuaj, nws tau pom tias noj nws rau nws lub hom phiaj tsis yog siv tau - muaj kev phiv ntau heev thiab teeb meem hauv kev sib xyaw nrog lwm cov tshuaj. Hauv cov txheej txheem ntawm kev tshawb fawb, ib qho txiaj ntsig anorexigenic tau sau tseg rau sibutramine - lub peev xwm los tiv thaiv kev qab los noj nyob rau theem ntawm lub hauv nruab nrab lub paj hlwb, tom qab ntawd cov tshuaj tau txiav txim siab txhais tau tias yog kev poob phaus.

Kev Pom Daws Hauv Kev Noj Haus

Thaum lub caij no, sibutramine hauv tshuaj yog hnub nyoog ntawm 10 thiab 15 mg. Thaum lub sij hawm sim tshuaj, cov tshuaj noj tau siv uas tau nce siab dua li cov tshuaj noj tam sim no. Qhov tshwm sim - poob phaus tau yooj yim thiab nrawm. Tus neeg mob lub qab los noj mov yuav luag ploj, thiab cov roj ntsha tau siv ob zaug ua haujlwm, vim tias lub zog xav tau ntawm lub cev xav tau kev txaus siab tas mus li.

Sibutramine hloov tawm mus rau qhov muaj txiaj ntsig tiv thaiv pathological tshaj qhov hnyav, thaum lub cev qhov hnyav Performance index mus tawm ntawm qhov ntsuas ntau tshaj 30. Kev tshawb fawb tuaj yeem hu ua qhov kev hloov kho tiag tiag hauv kev noj haus, yog tias tsis yog kev phiv tshuaj.Kev siv cov tshuaj loj loj tau nrog los ntawm ntau qhov tshwm sim, suav nrog:

• mob plawv thiab ntaus cwj nrag,
• lub siab tuaj cuam tshuam tuaj
• lub plab zom mov txhab,
• mob taub hau daj
• kev nyuaj siab mob hlwb.

Yog li ntawd, nyob rau theem ntawd lawv yuav tua tsis tau cov tshuaj mus rau kev siv loj. Muaj qhov pom cov tshuaj tsawg kawg nkaus, cov kws tshawb fawb tau ua tiav zoo hauv kev txo cov xwm txheej ntawm cov kev mob tshwm sim, uas ua rau nws muaj peev xwm rau npe rau cov tshuaj raws li cov tshuaj los kho kev rog.

Ntau lub tuam txhab kws tshuaj tau tsim cov mis thiab nws cov qauv. Txawm li cas los xij, qhov no tau hloov mus ua qhov tsis muaj kev vam meej tshwj xeeb, raws li cov lus txuas ntxiv hais txog yam tshiab tsis xav tau. Yog li ntawd, txij li xyoo 2010, Asmeskas thiab European Union tau suav nrog sibutramine nyob rau hauv daim ntawv teev cov tshuaj uas tsis raug cai. Qee lub tebchaws, piv txwv, Tebchaws Russia, suav nrog nws hauv cov npe ntawm cov tshuaj muaj hwj chim, txwv kev muaj peev xwm rau kev siv tshuaj rau tus kheej.

Lub cev hnyav txo

"Sibutramine" lossis nws cov analogues yog kws kho los ntawm kws noj haus los yog kws kho mob hlwb rau tib neeg muaj rog rog thiab noj zaub mov tsis zoo. Feem ntau qhov sib ntsib tau tshwm sim yog tias lwm txoj hauv kev txo qhov hnyav tau txhawm rau lawv tus kheej. Sibutramine ua rau lub cev raws li hauv qab no:

• thaiv cov kev ntes ntawm cov neurotransmitter serotonin,
• thaiv cov kev ntes ntawm cov neurotransmitter norepinephrine,
• rau ib tug tsawg npaum li cas raws inhibits dopamine uptake.

Kev ua txhaum ntawm kev noj thiab kev hloov kho ntawm cov neeg sib kho hauv nruab nrab cov hlab ntsha hauv lub hauv paus ua rau kev txhim kho ntawm cov txheej txheem zoo sib xws hauv txhua lub nruab nrog cev thiab cov ntaub so ntswg. Qhov tshwm sim ntawm kev noj sibutramine yog li hauv qab no:

• qab los noj mov - tus neeg mob nws tshaib plab heev heev, nws yuav tsis pom nws hlo li, txawm tias tsis muaj ib pluag mov nyob hauv ib hnub,
• cov metabolism - vim yog cov nyhuv ntawm lub suab vascular, hloov pauv tshav kub nce, lub cev tau yuam kom noj ntau lub zog, siv nws cov peev nyiaj los ntawm lub tsev,
• rog hlawv - raws li cov txiaj ntsig yav dhau los, txij li thaum siv zog sab nraud txo qis dua,
• satiation - vim tsis txaus siab noj mov, tus neeg mob lub siab tag nrho tshwm sim yuav luag tam sim ntawd tom qab pib noj mov,
• kev zom - ua kom zoo dua qub vim kev nce serotonin ntau hauv cov xoos ntawm lub plab zom mov (GIT), peristalsis thiab kua txiv ntau lawm txhim kho,
• kev zoo siab - txhim kho vim yog nce qib hauv "qib ntawm kev zoo siab", tus neeg mob zoo siab txawm tias muaj zaub mov noj,
• kev ua si - nce vim muaj kev cuam tshuam ntau ntxiv ntawm cov hlab ntsha hauv nruab nrab, tus neeg mob xav tias muaj zog ntawm lub zog, lub zog, npaj txhij rau kev ua thoob plaws ib hnub.

Tus lej ntawm cov kev hloov hauv lub hlwb uas ntxias los ntawm kev siv sibutramine pab txhawb qhov kev poob phaus ntawm txhua qib: lub cev, kev xav, hormonal. Ib qho ua tau zoo ntawm cov tshuaj yog nws lub peev xwm los ua kom muaj zog ntxiv hlawv ntawm "rog rog". Txawm hais tias cov kev txuam no muaj nyob hauv cov khoom me me hauv tib neeg lub cev, lawv ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm cov thermoregulation. Thiab lawv txoj kev sib cais activates tau noj ntawm "cov rog dawb", ib qho dhau heev lawm uas ua rau kev rog.

Nws kuj tseem muaj rau cov sibutramine los tswj cov rog hauv lub cev. Hauv tshwj xeeb, cov tshuaj ua kom muaj zog ntau lawm thiab ua kom tso tawm cov kua tsib. Vim li no, kev qhia txog kev siv tshuaj muaj xws li kev rog nyob rau hauv hom 2 mob ntshav qab zib mellitus thiab lipid metabolism cov teeb meem. Cov xwm txheej rau kev teem caij sibutramine nyob rau hauv cov rooj plaub no yog qhov tshaj ntawm lub cev huab hwm coj qhov ntsuas ntawm 27.

Cov lus qhia txog kev siv sibutramine

Sibutramine belongs rau cov pab pawg neeg rog dhau los kho qhov kev npaj "ua qhov kawg dhau los". Kev txais tos ntawm cov nyiaj yuav tsum tau pom zoo nrog tus kws kho mob kom ntseeg tau tias txhua txoj hauv kev ntawm kev txhim kho lub cev qhov hnyav tau dhau los. Cov kev sib txuam no yog qhov tsim nyog vim tias muaj kev pheej hmoo loj noj qab haus huv uas yog fraught nrog kev cuam tshuam hauv kev ua haujlwm ntawm lub paj hlwb.

Feem ntau, kev pib noj yuav tsum pib qhov tsawg ntawm 10 mg. Ib qho ntsiav tshuaj ntawm qhov tsim nyog qhov tshuaj yog noj ib zaug rau khob kom poob nrog cov kua txaus. Kev noj cov tshuaj tsis yog nyob ntawm lub sijhawm noj mov, tab sis cov kws kho mob pom zoo kom haus cov ntsiav tshuaj thaum sawv ntxov ntawm lub plab ib ce tom qab tsim los kom paub tseeb tias qhov ntau ntawm cov tshuaj hauv ntshav thaum sawv ntxov.

Qhov kev txiav txim tsim raws li hauv qab no:

• 80% ntawm cov ntsiab lus ntawm cov ntsiav tshuaj tau nqus hauv cov hnyuv,
• nquag metabolites ntawm sibutramine - raug tso tawm rau hauv cov ntshav thiab khi rau nws cov protein,
• ntshav siab nce mus txog qhov siab tshaj plaws - peb mus rau plaub teev tom qab noj,
• metabolites ntawm cov tshuaj - tau muab faib thoob plaws lub cev, cia hauv cov pob qij txha synaptic,
• tom qab noj cov ntsiav tshuaj thib plaub, ua kom ruaj khov kho cov tshuaj ntawm cov tshuaj tau tiav hauv cov ntaub so ntswg.

Txais tos yog undesirable mus ua ke nrog zaub mov. Qhov tseeb yog tias qhov nqus ntawm cov tshuaj los ntawm cov pob zaub mov noj zuj zus - nws txo qis los ntawm ib feem peb. Cov tshuaj no dhau tawm hauv lub cev los ntawm lub raum. Cov tshuaj tiv thaiv ntawm cov tshuaj metabolites nyob hauv cov ntaub so ntswg ntev li ib hlis, tab sis lawv cov kev xav tom qab kawg kev tswj hwm tsis muaj qhov tseem ceeb kho.

Kev noj tshuaj Sibutramin tuaj yeem siv txog ib xyoos. Tam sim no lawv kuj haus analogues. Yog tias qhov ntsuas qhov tsawg kawg nkaus ntawm 10 mg yog txaus siab, nws nyob twj ywm kom txog thaum kawg ntawm kev kho mob. Qhov xav tau nce ntxiv rau kev noj tshuaj tshwm sim yog tias, hauv ob rau peb hlis tom qab pib kev noj, "tus neeg mob" ntawm tus neeg mob tau txog 3% ntawm tag nrho lub cev qhov hnyav. Tom qab ntawd tau sau sibutramine hauv ib koob tshuaj 15 mg. Nyob rau hauv cov ntaub ntawv tias cov kav dej txuas ntxiv tseem tsawg, cov tshuaj tau raug muab tso tseg vim yog qhov tsis muaj txiaj ntsig. Txhua yam kev txiav txim siab hais txog ntau npaum li cas, nrog rau lub sijhawm sijhawm ntawm kev kho mob, yog tus kws kho mob ua tus txiav.

Raug Dab Tseeb

Muab cov kev pab tseem ceeb ntawm cov tshuaj hauv cov txheej txheem ntawm kev poob phaus, cov lus nug tshwm sim: "Kuv yuav tau them dab tsi rau qhov kev txhawb nqa pom tseeb ntawm txoj kev mus rau kev sib raug zoo?" Lo lus teb yog nyob rau hauv kev tshwm sim ntawm kev tshawb fawb ntawm cov raug, uas qhia meej meej nws cov kev mob tshwm sim. Tab sis tsom rau kev txheeb xyuas ntawm kev poob phaus, peb tuaj yeem hais tias feem ntau cov tshuaj tiv thaiv. Qee qhov tsis tsim nyog uas tshwm sim thaum pib ntawm txoj kev kho mob poob siv lossis ploj zoo dua yog tias sibutramine noj raug. Feem ntau cov kev mob tshwm sim:

• qhov ncauj qhuav
• ua txhaum ntawm cov quav
• exacerbation ntawm hemorrhoids,
• mob taub hau
• lub plawv dhia
• insomnia
• ua tiav tsis qab los noj mov,
• nce ntshav siab me ntsis.

Cov kev mob tshwm sim ntawm sibutramine, zoo li nrog lwm cov tshuaj, suav nrog kev muaj qhov tsis haum tshuaj, tshwm sim los ntawm urticaria thiab mob pruritus. Hauv qhov no, cov tshuaj raug muab tso tseg.

Cov kev mob tshwm sim hnyav ntxiv ntawm cov tshuaj muaj yees thiab tshem tawm. Kev quav yeeb tshuaj tsis tshwm sim, tab sis thawj zaug tom qab tsis kho kev kho mob, tus neeg mob lub siab ntsws yuav ua rau muaj mob ntau ntxiv, uas tuaj yeem ua rau rov qab mus noj qub. Txhawm rau txo qhov sib zog ntawm cov teebmeem no, cov kws kho mob pom zoo kom tsis txhob kho mob, maj mam txo cov tshuaj ntawm cov tshuaj.

Txaus ntshai yam tsis xav paub txog muaj xws li:

• kev xav hauv lub hlwb (mus txog qhov xav tua tus kheej),
• kev noj zaub mov tsis haum (bulimia, anorexia),
• nce kev pheej hmoo ntawm lub plawv nres,
• insomnia
• nce siab nyob rau hauv cov ntshav siab,
• tachycardia
• tsaus muag
• ua tsis taus pa peripheral.

Muab qhov tseeb tias yav dhau los sibutramine tuaj yeem muas tau yam tsis muaj daim ntawv yuav tshuaj, qee qhov kev mob tshwm sim tuaj yeem tsis sau npe los ntawm cov neeg tsim khoom thiab tsis muab tso rau hauv cov lus qhia. Cov kws kho mob tsom rau kev saib xyuas cov neeg uas poob phaus raws li qhov xav tau rau ib tus kws tshaj lij. Tsuas yog txoj hauv kev no qhov ua tau ntawm cov kev mob tshwm sim yog txo qis.

Orlistat (Orlistat, Orlistatum)

• Nws muaj cov nyhuv ntu khoom nruab nrab
• Tus txheej txheem ntawm kev ua yog zoo li tus cwj pwm ntawm triglycerides thaum cov lwg me me ntawm lub plab thiab lub cev ua rau lub plab hnyuv ntxig khi, tsis tso cai rau lawv cuam tshuam nrog lipids. Hauv lwm lo lus, cov plab hnyuv plab hnyuv hauv qab ntawm orlistat tsis tuaj yeem "zom" cov rog, uas raug tshem tawm ntawm lub cev lawm (piv txwv li nrog quav) thoob plaws lub txheej txheem hauv plab zom mov (hnyuv plab).
• Cov tshuaj tsis haum rau ntawm lub plab zom mov, i.e. xyaum tsis nkag mus rau hauv lub cev (feem ntau yog tawm tom qab 3 - 5 hnub, thiab li 2% yog tawm los ntawm lub raum)
• Lowers LDL (Tsawg Ceev Lipoproteins)
• Nce HDL (Kev kub ceev)
• Lowers ntshav siab (ntshav siab)
• Txo kom ceev nrawm
• Lawv tau siv nyob rau hauv kev kho mob ntawm, thiab txij li nrog lub tshuaj no them nyiaj ntawm cov metabolism carbohydrate tuaj yeem ua tiav
• Koob tshuaj pom zoo: 1 tshuaj ntsiav (120 mg) 3 zaug ib hnub twg nrog zaub mov

• Mob khaub thuas, roj quav
• Rectal roj tawm
• Tsis nco qab
• Txo kev nqus ntawm cov vitamins-soluble vitamins (multivitamin complex ua kom tsawg yog qhia)

Sibutramine (Sibutramine, sibutramine hydrochloride monohydrate)

• Nws muaj lub hauv paus ua haujlwm
• Nws yog ib qho anorexigenic uas txo kev qab los noj mov (tom qab ib tus neeg pib haus cov khoom noj tsawg dua)
• Txhim kho qhov kev xav ntawm tag nrho
• Tsub kom thermogenesis (tsub kom lub cev kub)
• Muaj zog HDL
• Txo ntshav LDL, triglycerides, roj (cholesterol) tag nrho, uric acid
• Tsub kom ntshav siab thiab nrawm rau lub plawv dhia, qee zaum rau qhov ntau ("dag" tshwm)
• Raug rau hauv lub cev 77%
• Nws cov txiaj ntsig siab tshaj plaws tshwm sim 1.2 teev tom qab noj tshuaj
• Siv nyob rau hauv kev kho mob rog nrog BMI ntawm 30 kg / m 2 lossis ntau dua lossis BMI ntawm 27 kg / m 2
• Yuav cuam tshuam rau cov ntshav platelet

• Insomnia
• Mob taub Hau
• Kiv taub hau
• Vauv
• Kev Txhawj Xeeb
• Paresthesia (hnov tsis zoo ntawm ntau qhov chaw ntawm lub cev)
• Saj pauv
• Mob puas hlwb thiab qaug dab peg hauv cov neeg mob cais
• Tachycardia
• Lub plawv palpitations
• Nce nyob rau hauv cov ntshav siab
• Cov kev phais (daim tawv nqaij hyperemia nrog kev hnov ​​ntawm qhov sov siab)
• Tus kab mob Shenlein-Genoch thiab mob thrombocytopenia hauv qee kis
• Lub qhov ncauj qhuav
• Tsis qab los noj mov
• Cem quav
• Zawv plab
• Xeev siab
• Exacerbation ntawm hemorrhoids

Hauv lwm lo lus, cov tshuaj no cuam tshuam cuam tshuam ob qho tib si rau nruab nrab lub paj hlwb thiab cov hlab plawv. Yog li, nws tsis tuaj yeem siv nrog rau lwm cov tshuaj ua yeeb yam rau cov leeg hlwb (tshuaj tiv thaiv kab mob hauv lub cev, tshuaj tiv thaiv kab mob, simptophanes). Nws nce lub nra rau lub siab thiab lub raum, vim tias nws nqus tau thiab nkag mus rau hauv lub cev los ntawm cov hnyuv.

Dua li ntawm qhov no, nws qhov siv ntev tau raug tso cai rau 1 xyoo!

Kws Tshuaj

Pharmacological kev txiav txim - anorexigenic.

Nws inhibits reuptake ntawm neurotransmitters - serotonin thiab norepinephrine los ntawm synaptic cleft, potentiates synergistic sib cuam tshuam ntawm lub hauv nruab nrab norepinephrine thiab serotonergic systems. Txo qhov qab los noj mov thiab cov zaub mov noj ntau dua (txhim kho lub siab ntawm tag nrho), nce thermogenesis (vim qhov ua kom tsis ncaj ntawm beta3-adrenergic receptors), muaj cov nyhuv ntawm cov nqaij mos adipose xim av. Nws ua cov nquag metabolites nyob rau hauv lub cev (thawj thiab theem nrab amines), ho zoo dua rau sibutramine hauv nws lub peev xwm los cuam tshuam rau reuptake ntawm serotonin thiab norepinephrine. Hauv kev tshawb nrhiav hauv vitro, cov tshuaj tiv thaiv metabolites tseem tuaj yeem thaiv dopamine, tab sis yog 3 zaug tsis muaj zog dua li 5-HT thiab norepinephrine. Tsis yog sibutramine los yog nws cov metabolites cuam tshuam rau kev tso tawm ntawm monoamines thiab MAO kev ua si, tsis txhob cuam tshuam nrog neurotransmitter receptors, suav nrog serotonergic, adrenergic, dopaminergic, benzodiazepine thiab glutamate (NMDA), thiab tsis muaj anticholinergic thiab antihistamine teebmeem. Cov tshuaj 5-HT platelet uptake thiab tuaj yeem hloov cov ntshav platelet.

Ib qho kev txo qis ntawm lub cev qhov hnyav yog nrog los ntawm kev nce ntxiv ntawm qhov kev xav ntawm HDL hauv cov ntshav dej thiab cov roj triglycerides txo qis, tag nrho cov roj (cholesterol), LDL thiab uric acid.

Thaum kho, muaj ntshav nce siab me ntsis thaum so (los ntawm 1-3 mmHg) thiab nce siab ntawm lub plawv dhia (los ntawm 3-7 yeej / min), tab sis nyob rau hauv cov kis mob sib cais ntau tshaj tawm tau hloov tau. Nrog tib lub sijhawm siv nrog microsomal oxidation inhibitors, lub plawv nce ntxiv (los ntawm 2.5 bpm) thiab QT cuam ncua ntxiv (los ntawm 9,5 ms).

Hauv 2-xyoo kev tshawb fawb hauv cov nas tsuag thiab nas thaum siv cov koob tshuaj, vim qhov tshwm sim ntawm qhov pom tag nrho thaj chaw hauv qab qhov nkhaus-sij hawm nkhaus (AUCs) rau ob qhov kev ua kom tau zoo yog 0.5–21 lub sijhawm siab dua li ntawm MRI, nce qhov tshwm sim ntawm cov qog benign testicular interstitial nqaij feem ntau cov txiv neej nas. Tsis pom muaj cov teebmeem carcinogenic hauv cov nas thiab poj niam nas. Nws tsis muaj qhov tshwm sim mutagenic, tsis muaj kev cuam tshuam kev tsis taus. Thaum cov nas tau muab cov koob tshuaj, AUCs ntawm ob lub cev siv tshuaj tiv thaiv uas tau 43 zaug ntau dua li cov uas tau pom nrog MRI, tsis muaj kev cuam tshuam teratogenic. Txawm li cas los xij, hauv cov kev tshawb fawb tau ua rau Dutch Belted luav raws li cov xwm txheej thaum AUCs ntawm kev siv tshuaj lom neeg sib xyaw ntawm sibutramine tau 5 zaug ntau dua thaum siv MRI, kev tsis pom kev ntawm lub cev txoj kev loj hlob tau pom hauv cov xeeb menyuam (cov kev hloov ntawm cov duab lossis loj ntawm lub caj pas, auricle, Tail, thiab pob txha tuab) )

Tom qab kev tswj hwm ntawm qhov ncauj, nws nrawm los ntawm lub plab zom mov tsawg kawg 77%. Thaum lub sijhawm "thawj hla" los ntawm lub siab, nws hla lub cev biotransformation nyob rau hauv kev cuam tshuam ntawm CYP3A4 isoenzyme ntawm cytochrome P450 nrog kev tsim ntawm ob lub zog metabolites (mono- thiab didemethylsibutramine). Tom qab noj ib koob tshuaj 15 mg ntawm Cmax, monodesmethylsibutramine yog 4 ng / ml (3.2-4.8 ng / ml), thiab didesmethylsibutramine yog 6.4 ng / ml (5.6-7.2 ng / ml). Cmax tau mus txog tom qab 1.2 teev (sibutramine), 3-4 teev (nquag metabolites). Kev noj mov ib txhij txo qis Cmax ntawm cov khoom noj tshuaj lom neeg txog 30% thiab nce sijhawm kom ncav cuag nws los ntawm 3 teev yam tsis hloov AUC. Nws yog sai faib rau ntawm ntaub. Kev khi cov protein yog 97% (sibutramine) thiab 94% (mono- thiab didesmethylsibutramine). Qhov sib luag ntawm cov tshuaj sib xyaw ua ke nyob rau hauv cov ntshav tau mus txog hauv 4 hnub tom qab pib kev kho mob thiab muaj kwv yees li 2 zaug siab dua qib ntshav ntxiv tom qab noj ib koob. T1 / 2 ntawm sibutramine - 1.1 teev, monodesmethylsibutramine - 14 teev, didesmethylsibutramine - 16 teev. Nquag cov khoom ua kom lub cev tsis haum thiab ua rau muaj kev sib xyaw nrog kev tsim cov tshuaj tiv thaiv tsis tau, uas tsuas yog tawm hauv lub raum.

Sibutramine yog dab tsi?

Sibutramine yog yeeb tshuaj muaj zog. Thaum pib, nws tau tsim tawm thiab sim ua tshuaj tiv thaiv kev ntxhov siab, tab sis cov kws tshawb fawb tau sau tseg tias nws muaj lub zog ua kom muaj zog, uas yog, nws muaj peev xwm txo qhov qab los noj mov.

Txij li xyoo 1997, nws tau siv nyob rau hauv Tebchaws Asmeskas thiab lwm lub tebchaws yog txoj hauv kev zoo rau poob phaus, qhia rau cov neeg uas muaj ntau yam kabmob sib kis. Cov Kev Mob tshwm sim tsis ntev hauv los.

Nws muab tawm tias sibutramine muaj yees thiab muaj kev nyuaj siab, uas tuaj yeem piv nrog tshuaj yeeb yaj kiab. Ntxiv rau, nws tau nce ntau qhov kev pheej hmoo ntawm cov kab mob plawv, ntau tus neeg tau mob plawv thiab mob plawv thaum noj nws. Muaj cov ntaub ntawv ua pov thawj tsis raug cai uas siv cov sibutramine ua rau kev tuag ntawm cov neeg mob.

Rau leej twg cov nyiaj yog txwv tsis pub

Sibutramine-based tshuaj muaj npe zoo txaus ntshai ntawm cov muaj mob hnyav contraindications. Lub ntsiab tseem ceeb yog kev ua txhaum nyob hauv kev ua haujlwm hauv lub plawv, nplooj siab thiab ob lub raum, txij li cov khoom tsim cov khoom hnyav rau cov kabmob no.

Qhov kev puas tsuaj rau yeeb tshuaj yog qhov tseem ceeb ntxiv yog tias kev rog tsis yog keeb kwm alimentary, tab sis yog theem nrab. Feem ntau, cov teeb meem hauv lub cev tsis ua haujlwm thiab ua haujlwm ntawm cov nruab nrog cev ua rau nws.Kev ua hauv kev kho mob ua pov thawj qhov tsis muaj peev xwm ntawm sibutramine hauv cov xwm txheej zoo li no. Lwm yam contraindications rau kev noj cov tshuaj:

• tsis tau muaj 18 xyoo
• tom qab 65 xyoos
• nrog bulimia,
• nrog tsis nco qab,
• kev nyuaj siab mob hlwb
• hyperthyroidism
• leeg ntshav siab
• prostate adenoma
• mob ntsws
• kev quav yeeb tshuaj
• quav tshuaj
• quav cawv.

Kev saib xyuas tshwj xeeb yuav tsum tau teem sij hawm sibutramine rau kev puas ntsoog thiab cov neeg muaj mob chua leeg, nrog rau cov neeg tsis muaj ntshav lossis ntshav khov.

Muab cov kev pheej hmoo ntau ntxiv ntawm kev haus ntau dhau thiab teeb meem, haus cawv yuav tsum tau tso tseg kiag thaum kho. Txhawm rau tshem tawm cov tshuaj los ntawm cov kab mob muaj sia, overdosed txhob txwm lossis yuam kev, lub plab zom zaub mov yuav tsum tau nqa tawm, ib qho adsorbent yuav tsum tau nqa thiab ib lub tsheb thauj neeg mob yuav tsum raug hu.

Qhov twg yog qhov zoo tshaj plaws cov kev poob phaus?

Lub sijhawm tau los coj cov txiaj ntsig me thiab xaiv qhov tsawg kawg ntawm ob qhov kev ua phem (yog tias qhov no tuaj yeem ua tau txhua).

Peb yuav tsis nkees ntawm ceeb toom rau txhua tus nyeem tias nws yog qhov zoo tshaj plaws los muab qhov kev nyiam ua rau lub ntuj tshaj plaws tsis tas siv tshuaj thiab yog qhov zoo rau lawv cov kev pab tsuas yog thaum lub sijhawm tseem ceeb thaum kev kho ntxiv yog tsis muaj yam tsis muaj lawv. Nws yog qhov zoo dua rau kev ua raws li qhov uas tau txhim kho nyob rau hauv Soviet lub sijhawm thiab txog niaj hnub no, cov khoom noj khoom haus niaj hnub tsis tau muaj kev hloov pauv hnyav rau cov txheej txheem ntawm cov khoom noj khoom haus kho mob.

Tab sis vim tias tus kws kho mob tau sau tseg, ces cia peb xav txog ob yam tshuaj twg uas yuav ua rau muaj kev phom sij tsawg?

Rov qab hais tias tsis muaj ib qho kev sim tsim nyog rau kev tshuaj xyuas tseeb txog niaj hnub no. Tag nrho cov ntaub ntawv hais txog lawv cov txheeb ze kev nyab xeeb yog los ntawm kev ntsuam xyuas nqa ntawm cov tsiaj, thiab qhov no twb ua rau peb cov txiaj ntsig ib qho kev tsis txaus ntseeg. Tab sis cia qhia rau koj tsis pub lwm tus paub, feem ntau ntawm cov tshuaj muag hauv khw muag tshuaj ntawm Lavxias teb sab tsis tau kuaj tsis raug (feem coob tsis tuaj yeem hu ua "tshuaj", vim tias lawv tsom mus rau tsis kho, tab sis rau kev txo qis ntawm cov tsos mob tseem ceeb ntawm tus kab mob). Lub ntsiab tseem ceeb nyob rau hauv cov tshuaj niaj hnub yog tias lawv "ua haujlwm", thiab ua li cas raws nraim yog theem nrab thiab tsis yog qhov teeb meem tseem ceeb.

Dab tsi yog qhov sib txawv tseem ceeb ntawm ob qho yeeb tshuaj no?

Cia peb xav txog lawv los ntawm qhov pom ntawm cov txheej txheem assimilation thiab cov txheej txheem ntawm kev sib kis, txij li yog tias ib yam khoom muaj peev xwm ua kom tawm ntawm lub cev, ces nws, txawm hais tias nrog lub ncab, tuaj yeem hu ua tsis muaj mob.

Txij li feem ntau ntawm sibutramine tom qab qhov ncauj tswj hwm tau sai sai los ntawm peb lub cev, thiab nws cov kev mob tshwm sim yog qhov dav heev, nws yog qhov zoo dua rau tso tseg nws siv rau cov uas muaj teeb meem loj rau daim siab thiab lub raum. Tsis tas li ntawd, nws ua haujlwm ntawm lub hauv nruab nrab lub paj hlwb, txo cov kev xav, ua rau tib neeg tsis nco qab, cuam tshuam, thiab tsaug zog. Nws tsis pom zoo rau cov neeg uas tsav tsheb txhua hnub lossis tsav lub tsheb sib txawv.

Lub spectrum ntawm kev txiav txim ntawm cov khoom no yog qhov dav heev, yog li ntawd, nws yog qhov zoo tshaj rau kev mob siab rau orlistat, uas yuav luag txhua qhov tawm ntawm lub cev. Nws, zoo li, muab ib qho kev pabcuam tsis zoo rau lub cev, vim nws "ntxuav" txhua yam khoom noj uas nkag hauv plab los ntawm cov rog, tab sis peb kuj yuav tsum them nyiaj rau qhov kev pabcuam no, vim tias ntau tus neeg mob noj orlistat npaj muaj nrog mob raws plab thiab lwm yam teeb meem nrog lub plab. Nws tsis tshua muaj txiaj ntsig zoo sibutramine, yog li nws cov tshuaj nyob rau hauv ib lub tshuaj ntsiav yog ntau dua 100 mg (los ntawm 120 mg).

Txawm hom tshuaj twg koj xaiv, nco ntsoov nco ntsoov tias nws tsis pom zoo siv lawv yam tsis tau sab laj nrog kws kho mob!

Cov kev xaiv yog ib txwm koj, tab sis nws yog qhov zoo dua los muab kev nyiam ua kis las thiab ua kom tau zaub mov kom zoo!

Noj qab nyob zoo thiab zoo siab!

Nrog lub hom phiaj ntawm kev poob phaus, ntau tus ntxhais thiab poj niam noj tshuaj tshwj xeeb kom tshem tawm qhov hnyav. Cov no suav nrog cov ntsiav tshuaj uas muaj sibutramine. Ua ntej koj pib npaj cov tshuaj xws li tshuaj, koj yuav tsum nyeem cov lus qhia rau kev siv sibutramine muab hauv qab no.

Txais tos thaum cev xeeb tub thiab lactation

Cov kws tshwj xeeb categorically txwv tsis pub noj cov tshuaj rau cov poj niam uas tab tom nyob rau theem ntawm cev xeeb tub lossis lactation. Hauv cov xwm txheej no, qhov cuam tshuam ntawm cov ntsiav tshuaj yuav tsis zoo rau tus niam, tab sis kuj rau nws tus menyuam hauv plab. Cov lus qhia no yuav tsum tsis txhob hnov ​​qab, txij li ntau tus neeg mob uas tsis zoo thiab txawm tias muaj kev tuag tau pom tias tau ua dhau los ntev.

Sab sij huam

Thaum noj cov tshuaj kom txo qhov hnyav, qee qhov kev mob tshwm sim yuav tshwm sim. Lawv tuaj yeem muaj ob qho tib si luv luv thiab ntev ntev. Yog tias lawv pom lawm, koj yuav tsum qhia koj tus kws kho mob paub tseeb txog nws, vim tias nws yuav muaj qhov phom sij ua rau koj muaj mob yog tias koj tseem noj tshuaj.

Daim ntawv teev cov kev mob tshwm sim yuav tsum muaj:

• cem quav
• tsis qab los noj mov
• paresthesia
• xeev siab
• ntshav siab
• mob taub hau
• qaug dab peg
• thrombocytopenia
• exacerbation ntawm hemorrhoids,
• saj hloov
• ntxhov siab
• kiv taub hau
• liab nyob rau ntau thaj chaw ntawm daim tawv nqaij,
• interstitial nephritis.

Kev cuam tshuam nrog lwm yam tshuaj

Feem ntau muaj kev tshuaj xyuas ntawm cov neeg uas poob phaus ntawm Sibutramine txog nws txoj kev cuam tshuam nrog lwm cov tshuaj. Thaum kho nrog tus neeg sawv cev no, nws tsim nyog nco ntsoov tias thaum siv cov ntsiav tshuaj nrog erythromycin, ketoconazole, cyclosporine thiab lwm yam tshuaj uas cuam tshuam rau kev ua haujlwm ntawm CYP3A4, qhov tseem ceeb ntawm cov tshuaj metabolites hauv plasma tuaj yeem yooj yim nce ntxiv, qhov txiaj ntsig ntawm qhov QT interval yuav nce ntxiv.

Txoj kev pheej hmoo ntawm serotonin syndrome kev vam meej yuav nce ntxiv thaum noj Sibutramine thiab cov tshuaj hauv qab no:

• opioid tshuaj loog,
• Paroxetine
• Fluoxetine
• central hnoos suppressants,
• "Citalopram".

Siv rau txawv teb chaws

Sibutramine thiab cov tshuaj zoo sib xws tau nquag siv tsis yog nyob hauv Russia xwb. Piv txwv li, hauv Tebchaws Asmeskas cov khoom lag luam tawm los ntawm cov npe lag luam "Meridia" thiab tsuas yog muag raws li kws kho mob hais. Cov kws tshaj lij hauv zos, uas tau ua ntau qhov kev sim rau cov neeg ua haujlwm pab dawb nrog ntau qib ntawm kev rog, yog li tau txais tsawg kawg ntawm cov neeg tuag. Vim li no, lawv tso cai rau cov ntsiav tshuaj noj tshwj xeeb los ntawm cov neeg mob noj qab haus huv uas tsis muaj teebmeem kev noj qab haus huv, tshwj xeeb tshaj yog cov kab mob plawv.

Hauv European Union, kev tshaj tawm Sibutramine raug tso tseg. Qhov laj thawj rau qhov no yog qhov kev tshawb pom los ntawm cov kws paub txog qhov tsis zoo rau kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha. Txhawm rau kom paub meej txog qhov no, ntau cov kev tshawb fawb tau ua rau tib neeg kev txom nyem los ntawm cov kab mob ntawm cov plab hnyuv siab raum, qhov twg cov txiaj ntsig tsis tau muaj kev nplij siab ntxiv.

Qee tus neeg tsis tuaj yeem them yuav "Sibutramine", yog li lawv tab tom nrhiav cov tshuaj uas zoo ib yam li nws hauv kev ntsuas thiab kev ua haujlwm. Zoo hmoo, muaj ntau yam khoom zoo li no. Tab sis tib lub sijhawm, nws tsim nyog nco ntsoov tias cov nyiaj uas muaj sibutramine tsuas yog muag los ntawm cov tshuaj. Cov muaj npe tshaj ntawm lawv yog:

1. Meridia Ib hom tshuaj kho mob hauv German yog npaj los txo qhov hnyav thiab rov ua haujlwm rau tus neeg mob lub siab-siab ntsws lub xeev. Nws siv nyob rau hauv kom meej meej tsuas tshuaj, txawm hais tias nws yuav tsum tau ntau dua koob tshuaj ntev. Cuab yeej muaj cov npe loj heev ntawm cov kev mob tshwm sim thiab cov sib txuam uas muaj feem cuam tshuam nrog kev pheej hmoo rau tib neeg lub neej.
2. Ntxim Nyias. Ib cov tshuaj zoo yog tswj qhov txo lub cev hnyav. Nws muaj peev xwm leeb lipid metabolism thiab txuag tus neeg mob los ntawm kev noj zaub mov noj. Qhov kev hais daws zoo heev, tab sis chav kawm ntawm kev kho mob ntev tshaj rau lub hlis.
3. "Obstat." Ib qho cuab yeej tsim los tswj cov nyhav, ua haujlwm tsis tsuas yog nws lub luag haujlwm tseem ceeb, tabsis tseem muaj qee tus ntxiv. Nws kho txoj kev noj zaub mov kom zoo thiab siv tshwj xeeb rau kev kho mob rog rog morbid.
4. Lindax. Cov neeg yuav cov tshuaj noj kom txo qis kev noj haus zoo. Cov kws kho mob sau ntawv rau cov tshuaj no kom hloov pauv kev noj zaub mov thaum tsis tuaj yeem cuam tshuam txog kev tshaib plab mus rau lwm txoj kev. Xws li cov tshuaj tsis quav tshuaj thiab tsis pub tsim kom muaj kev vam khom rau nws cov khoom siv.
5. Txwv Tsawg. Cov cuab yeej no siv ncaj qha hauv ntau lub tebchaws, tab sis tsuas yog qhia los ntawm kws kho mob. Nws pab tua cov phaus ntxiv kom nrawm heev, yam uas tsis ua rau muaj yees.

Cov lus piav qhia ntawm "Sibutramine" kuj tseem muaj. Oddly txaus, ntawm lawv tsis muaj lus tsis zoo ntawm cov neeg yuav, vim tib neeg muaj kev txaus siab nrog lawv tes haujlwm. Txawm hais tias muaj kev mob tshwm sim, qhov kev ua tau zoo ntawm cov tshuaj tsuas yog txaus ntseeg. Ua tsaug rau qhov no, Sibutramine analogues tsis muaj tsawg dua. Lawv tau txais thiab nquag siv los ntawm cov neeg nyob hauv ntau lub teb chaws, tau txais cov txiaj ntsig zoo.

Cov lus teb zoo

Niaj hnub no muaj ntau cov kev tshuaj xyuas kev poob zoo txog Sibutramin. Lawv sab laug los ntawm cov neeg ntawm cov hnub nyoog sib txawv uas tau muaj lossis tau kam nrog qhov tshuaj no.Cov neeg yuav khoom hauv lawv cov lus taw qhia txog qee yam tshwj xeeb uas txawv cov ntsiav tshuaj no los ntawm cov tshuaj sib tw, nrog rau kev ua tau zoo.

Feem ntau, kev txheeb xyuas yog sab laug los ntawm cov neeg yuav khoom uas twb tau ntsib nyiaj ntau lawm thiab tsis tuaj yeem tau txais cov txiaj ntsig ntawm lawv. Lawv tau sib cav hais tias Sibutramin maj mam txo qis lawv qhov qab los thiab pab kom poob phaus ntxiv hauv thawj lub lim tiam ntawm kev pub nkag mus. Cov neeg tau txais kev pab kuj hais tias lawv tsis muaj kev mob tshwm sim txhua lub sijhawm lossis nthuav qhia rau lub sijhawm luv luv, yog li tsis muaj laj thawj ntawm kev txhawj xeeb.

Tshwj xeeb feem ntau, tib neeg qhia tias tom qab ib txoj kev kho, nyhav thiab qab los noj mov tsis rov qab los. Ua tsaug rau qhov no, tsis muaj kev rau siab koj tuaj yeem ua kom haum thiab txawm tias ua tiav cov txiaj ntsig tshiab, tab sis tsis tas yuav siv nyiaj hauv tshuaj ntsiav

Phiv los sis fab Sibutramine

Hauv kev kawm tshuaj placebo, 9% ntawm cov neeg mob tau txais sibutramine (n = 2068) thiab 7% ntawm cov neeg mob tau txais cov placebo (n = 884) tsis kho vim muaj kev phiv.

Hauv cov kev tshawb fawb tshuaj placebo, feem ntau cov kev mob tshwm sim yog lub qhov ncauj qhuav, tsis nco qab, pw tsaug zog, cem quav, thiab mob taub hau.

Cov hauv qab no yog cov kev mob tshwm sim uas tau pom nyob hauv cov neeg mob noj sibutramine, muaj ntau zaus ntawm ≥1% thiab feem ntau ntau dua li siv cov pawg. Qhov nquag ntawm kev tshwm sim ntawm cov kev mob tshwm sim hauv pawg uas noj sibutramine yog qhia nyob ib sab ntawm lub npe, hauv kev thaiv kab yog cov ntaub ntawv zoo sib xws hauv cov pab pawg.

• Lub cev raws li tag nrho: mob taub hau - 30.3% (18.6%), mob nraub qaum - 8,2% (5.5%), kev mob khaub thuas zoo li mob - 8.2% (5.8%), raug mob los ntawm kev tsis taus - 5.9% (4.1%), asthenia - 5.9% (5.3%), mob plab - 4.5% (3.6%), mob hauv siab - 1.8% (1.2%), mob nyob rau hauv caj dab - 1.6% (1.1%), kev tsis haum - 1.5% (0.8%).
• Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis): tachycardia - 2.6% (0.6%), vasodilation (ua pa ntawm daim tawv nqaij nrog qhov pom ntawm sov) - 2.4% (0.9%), mob taub-txhaus - 2.4% (2.0%), ntshav siab / ntshav siab ntxiv - 2.1% (0.9%), lub siab - 2.0% (0.8%).
• Los ntawm cov hnyuv: anorexia - 13.0% (3.5%), cem quav - 11,5% (6.0%), qab los noj mov - 8.7% (2.7%), xeev siab - 5.9% (2.8 %), dyspepsia - 5.0% (2.6%), mob plab - 1.7% (1.2%), nqhis dej - 1.7% (0.9%), ntuav - 1.5% (1 , 4%), exacerbation ntawm hemorrhoids - 1.2% (0.5%).
• Los ntawm cov leeg musculoskeletal: arthralgia - 5.9% (5.0%), myalgia - 1.9% (1.1%), tendosynovitis - 1.2% (0.5%), mob sib koom tes - 1.1% (0.6 %).
• Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: qhov ncauj qhuav - 17.2% (4.2%), insomnia - 10.7% (4.5%), kiv taub hau - 7.0% (3.4%), kev poob siab - 5.2% (2, 9%), ntxhov siab - 4,5% (3.4%), kev nyuaj siab - 4.3% (2.5%), kab mob poj niam - 2.0% (0.5%), tsaug zog - 1.7% ( 0.9%), arousal - 1.5% (0.5%), lub siab lub ntsws - 1.3% (0.6%), hloov pauv saj - 2.2% (0.8%), mob pob ntseg - 1.7% (0.9%), mob pob ntseg - 1.1% (0.7%).
• Los ntawm tus txheej txheem ua pa: rhinitis - 10.2% (7.1%), pharyngitis - 10.0% (8,4%), mob ntsws - 5.0% (2.6%), hnoos nce ntxiv - 3.8% (3.3 %), mob laryngitis - 1.3% (0.9%).
• Ntawm feem ntawm daim tawv nqaij: pob - 3.8% (2.5%), tawm hws - 2.5% (0.9%), Cov kab mob pob sawv ntshav - 1.3% (1.0%), mob ntxau - 1.0% (0.8) %).
• Los ntawm genitourinary system: dysmenorrhea - 3.5% (1.4%), mob txeeb zig - 2.3% (2.0%), mob voos ntawm lub paum - 1.2% (0.5%), metrorrhagia - 1.0% (0 , 8%).
• Lwm yam: kev tso npe dav dav - 1.2% (0.8%).

Kev kho mob ua ntej, lub sijhawm thiab tom qab cev xeeb tub

Qee zaum kev rog yog qhov ua rau muaj kev tsis txaus ntseeg hauv ntau ntau hauv cov poj niam, nws txwv tsis pub muaj menyuam, cev xeeb tub thiab yug tus menyuam noj qab nyob zoo. Qhov xwm txheej yuav tsum muaj kev noj haus thiab kev kho mob kev cuam tshuam. Yog tias lwm txoj kev ntawm kev ntsuas kev hnyav tsis ua hauj lwm zoo, sibutramine tuaj yeem tsim ua ntej muaj menyuam hauv plab. Nws yog ib qho tseem ceeb xav txog tias cov tshuaj muaj cov nyhuv teratogenic, uas yog, nws tuaj yeem tsim kev tsis tuaj yeem hauv kev txhim kho ntawm lub cev xeeb tub.

Rau tag nrho lub sijhawm ntawm kev kho mob, tus pojniam yuav tsum muab kev tiv thaiv kom tsis muaj txiaj ntsig. Los ntawm qhov kawg ntawm qhov kawg ntawm kev kho mob mus rau lub caij ntawm xeeb, tsawg kawg yog ob lub hlis yuav tsum dhau. Nyob rau lub sijhawm no, lub cev yuav ua kom tshem tawm cov seem ntawm cov tshuaj yeeb dej caw. Txoj kev kho nrog cov tshuaj thaum cev xeeb tub thiab pub niam mis yog txwv tsis pub ua.

Tag nrho cov khoom noj ntawm Sibutramin yog cov tshuaj:

Cov qauv qib ntawm Sibutramine yog Goldline Plus thiab Reduxine Met.Ntxiv rau cov tshuaj nquag, microcrystalline cellulose muaj nyob rau hauv lawv cov muaj pes tsawg leeg, uas ua kom muaj zog ntxiv cov nyhuv anorexigenic ntawm sibutramine. Reduxin Met kuj suav nrog metformin, ib yam khoom muaj zog ntawm cov neeg lub cev lub cev rau insulin.

Tag nrho cov tshuaj analog yog qhov tsis zoo tib yam uas sibutramine muaj kev txaus ntshai, muaj tib yam contraindications thiab phiv. Goldline Lub teeb kev noj haus ntxiv tsis muaj sibutramine, thiab yog li tsis tuaj yeem piv nrog cov tshuaj qub.

Ntawm cov kev hloov chaw nyab xeeb rau sibutramine, Xenical yog cov nyiam tshaj plaws. Nws cov tshuaj ua haujlwm, orlistat, yog nyob deb ntawm kev kawm txog tshuaj ntau tshaj plaws rau kev poob phaus nrog pov thawj kev nyab xeeb thiab siv tau. Cov tshuaj yeeb yam tsuas yog ua rau hauv plab hnyuv lumen, txhawm rau nqus cov rog, thiab tsis cuam tshuam rau hauv nruab nrab lub paj hlwb.

Muaj ntau tus naj npawb ntawm cov neeg uas rau ib qho laj thawj lossis lwm qhov kev txom nyem los ntawm qhov hnyav dhau. Kev tshem ntawm nws tsis yog ib qho yooj yim. Kev tawm dag zog, kev noj haus tsis yog qhov ib txwm ua tau txiaj ntsig. Ib qho ntxiv, ntxiv rau qhov tseeb tias nws yog qhov tsim nyog los nrog cov kev txwv qee yam, nrog rau kev faib qee lub sijhawm rau cov txheej txheem no, nws yog qhov tsim nyog kom muaj lub zog zoo. Vim li ntawd coob leej thiaj li mob siab txog cov tshuaj, tshwj xeeb, tshuaj Sibutramine Kev Tawv Rog .

Tus naj npawb ntawm cov neeg uas rog yog txhua xyoo. Raws li qhov tseeb, qhov kev tu ncua ntawm cov teeb meem nce zuj zus. Kev hnyav dhau tsis yog qhov teeb meem ntawm qhov tsos xwb. Qhov no tseem ua rau kev mob hlwb tsis zoo: ib tus neeg qhuas txog nws daim duab. Nws yog nyob deb ntawm ib txwm ua tau kom tau tshem ntawm qhov hnyav tshaj, txawm tias koj mus rau hauv kev ua kis las txhua hnub thiab noj kom raug. Vim li ntawd cov kws kho mob tau sau ntawv noj tshuaj, tshwj xeeb, Sibutramine.

Sibutramine yog tawm rau cov neeg uas raug kev hnyav thiab rog dhau. Hauv qhov no, ib qho ntawm cov xwm txheej tseem ceeb tshaj plaws yog qhov tsis muaj txiaj ntsig thaum siv lwm txoj hauv kev poob phaus, piv txwv li ua raws li kev noj zaub mov kom zoo, kev noj zaub mov zoo, kev tawm dag zog thiab kev tawm dag zog. Txawm hais tias qhov tseeb tias cov tshuaj Sibutramine ua haujlwm tau zoo thiab tom qab nws cov chav kawm tau qhov txiaj ntsig zoo, nws yuav tsum nkag siab tias cov ntsiav tshuaj no yog yeeb tshuaj muaj zog.

Thov nco tseg: Zoo li ntau lwm yam tshuaj, Sibutramine muaj nws cov kev mob tshwm sim thiab qee qhov sib txuam.

Sibutramine, zoo li txhua yam tshuaj, yuav tsum tau siv tom qab sab laj nrog tus kws kho mob paub, vim tias siv cov khoom tsis raug cai tuaj yeem ua rau muaj kev phiv tshuaj thiab kev haus ib ce ntau dhau. Feem ntau, kev ntsuam xyuas ntawm kev poob phaus ntawm Sibutramine yog ntau yam. Tom qab txhua yam, zoo li ntau lwm yam tshuaj, nws yuav tsis haum rau ib tus neeg.

Cov ntaub ntawv dav dav

Cov tshuaj no tau tshwm sim ntau dua ob xyoo dhau los. Sibutramine muaj lub hauv paus rau kev kho mob ntawm cov rog thiab lub cev poob. Nws yog tsim nyog kom nkag siab tias kev poob ceeb thawj tsuas yog los ntawm kev noj cov tshuaj no yuav tsis ua haujlwm. Sibutramine raug nquahu kom tsuas yog siv nrog kev noj zaubmov tshwjxeeb nrog rau kev noj zaubmov tshwjxeeb, nrog rau kev ua kom lub cev tsis tu ncua thiab maj mam dhau los.

Thawj qhov uas tau hnov ​​nyob tom qab noj Sibutramine ntsiav tshuaj yog kev zoo nkaus. Txawm hais tias koj noj ib qho me me ntawm cov khoom noj, nws txaus rau lub cev thiab nws yuav muaj txhij txhua. - Nov yog ib qho ntawm cov tseem ceeb tshaj ntawm Sibutramine. Qhov no tshwm sim vim nws cov nyhuv ntawm ntu ntawm lub hlwb uas yog lub luag haujlwm rau satiety. Raws li, qhov no ua rau qhov tseeb tias tus neeg mob noj tsawg dua cov zaub mov, cov khoom tshwj tseg thiab lub cev muaj roj hlawv.

Lawv siv rau qhov kev siv ntawm cov tshuaj no yog tias lwm yam kev ntsuas tsis muaj cov txiaj ntsig uas xav tau hauv kev poob phaus. Nws yog nyob rau hauv qee qhov tshwj xeeb no uas cov kws kho mob pom zoo kom noj Sibutramine ntsiav tshuaj. Lub sijhawm tag nrho kev kho mob, tus neeg mob yuav tsum nyob hauv kev saib xyuas ntawm tus kws kho mob tshwj xeeb hauv cov teeb meem poob phaus.

Ib qho ntxiv, cov haujlwm hauv qab no yuav tsum raug tshaj tawm:

• kev noj yus tus kheej,
• kev hloov kho ntawm kev ua neej thiab qee yam cwj pwm,
• nce kev tawm dag zog, kev ua kis las.

Cov Khoom Sib Haum Sibutramine

Thaum pib, cov tshuaj no tau tsim hauv Tebchaws Asmeskas, tab sis niaj hnub no nws tau raug txwv rau kev siv hauv cov tebchaws xws li Canada, Europe, Australia, Tebchaws Asmeskas. Qhov no yog vim qhov tseeb hais tias muaj qhov tsis zoo ntawm sibutramine ntawm cov hlab plawv tau raug pov thawj. Hauv tebchaws Russia, ib yam tshuaj, zoo li nws txoj kev ua noj tshuaj, tuaj yeem yuav tom chaw muag tshuaj nkaus xwb los ntawm cov tshuaj noj. Nws yuav tau ua cov npe cov yeeb yam muaj hwj chim. Txawm li cas los xij, nws tau sau tseg tsuas yog nyob rau hauv qhov tsis muaj ntawm cov nyhuv ntawm cov pluas noj thiab kev siv lub cev.

Cov ntxhais hluas niaj hnub no yuav yuag yuag thiab yuag yuag. Mus rau lub hom phiaj no tsis yooj yim li, tab sis ntau yam tshuaj yog cov txiaj ntsig zoo hauv kev ua haujlwm. Kev txheeb xyuas qhov poob phaus ntawm "Sibutramine" sib cav hais tias cov tshuaj no ua tau zoo tiag tiag. Cov cuab yeej no pab kom poob phaus sai sai, tab sis tsuas yog ua raws li cov cai rau nws siv thiab khaws cia.

Thaum kawm txog kev ua tau zoo ntawm cov tshuaj, cov neeg txaus siab rau cov lus qhia thiab tshuaj xyuas ntawm "Sibutramine." Qhov tseeb, nws txawv ntawm nws cov neeg sib tw hauv qee cov yam ntxwv uas tau ua pov thawj hauv daim ntawv thov. Yog tias koj tsis ua raws li cov kev cai uas tau teev tseg hauv cov lus qhia, koj yuav tsum tsis suav txog qhov ua tau zoo, tab sis koj tuaj yeem ua rau koj txoj kev noj qab haus huv koj txoj kev noj qab haus huv sai npaum li no.

Hauv tsab xov xwm koj tuaj yeem nrhiav cov ntaub ntawv hais txog cov tshuaj siv yog dab tsi. Cov lus qhia ntawm Sibutramina, cov lus qhia rau kev siv thiab tshuaj xyuas - tag nrho cov no yuav tseem ceeb rau ob tus poj niam thiab txiv neej uas tsis txaus siab rau lawv cov duab.

Cov lus qhia tshwj xeeb

Daim ntawv thov tsuas yog ua tau rau hauv cov xwm txheej uas txhua yam kev ntsuas txhawm rau txo lub cev qhov hnyav tsis muaj txiaj ntsig. Kev kho yuav tsum tau ua nyob ntawm kev saib xyuas ntawm kws kho mob nrog kev paub txog kev txhim kho kev rog yog ib feem ntawm kev kho mob nyuaj (kev noj zaub mov, hloov kev noj haus thiab kev ua neej, kev ua si lub cev). Qhov tshuaj ntawm 15 mg yuav tsum tau txwv tsis pub dhau lub sijhawm.

Cov nyhuv ntawm sibutramine ntawm lub cev

Sibutramine yog cov txheej txheem zoo ib yam li amphetamines, txawm hais tias nws tsis tau txais nrog lawv lub zog lom. Nws yog lub zog nruab nrab rau kev ua yeeb yam, ib qho inhibitor ntawm reuptake ntawm serotonin, norepinephrine thiab dopamine.

Yog li, cov nyhuv ntawm sibutramine ntawm lub cev raug txo kom txo kev tshaib kev nqhis los ntawm qhov nce ntawm serotonin hauv lub cev. Kev noj tshuaj nrog sibutramine tswj kev qab los noj mov, ua rau muaj kev xav sai, txo qhov kev xav tau rau kev ua kom yuag, ua kom lub cev zom zaub mov sai - lub cev pib siv nws cov rog rog, thiab cov ntaub so ntswg nqus tau zoo dua.

Tom qab noj sibutramine, nws zoo rau hauv kev zom zaub mov thiab metabolized hauv lub siab nrog kev tsim cov tshuaj yeeb dej caw. Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav tau sau tseg ib teev thiab teev tom qab noj tus neeg sawv cev rau tus kws kho mob, ua kom cov khoom noj tshuaj lom neeg lub cev - tom qab peb teev.

Cov chaw muag tshuaj

Sibutramine thaiv kev thim rov qab ntawm cov neurotransmitters (norepinephrine thiab serotonin) los ntawm synftic cleft, txhim kho synergistic kev cuam tshuam ntawm central serotonergic thiab norepinephrine systems. Txo cov khoom noj kom tsawg thiab qab los noj mov (txhim kho qhov kev xav ntawm tag nrho), cuam tshuam rau daim ntaub adipose xim av, nce thermogenesis (vim yog kev ua haujlwm tsis ncaj ntawm beta3-adrenergic receptors). Sibutramine ua rau lub cev muaj zog hauv lub cev, uas muaj peev xwm dhau ntawm nws lub peev xwm los tiv thaiv qhov tsis muaj zog ntawm norepinephrine thiab serotonin. Ntxiv rau, cov metabolites no tseem thaiv qhov rov qab noj cov tshuaj dopamine, tab sis tsuas yog 3 zaug tsis muaj zog dua li norepinephrine thiab serotonin. Sibutramine nrog nws cov metabolites tsis muaj feem cuam tshuam rau MAO kev ua haujlwm thiab kev tso tawm monoamines, tsis muaj antihistamine thiab anticholinergic cov teebmeem, thiab tsis cuam tshuam nrog neurotransmitter receptors (suav nrog adrenergic, serotonergic, benzodiazepine, dopaminergic thiab glutamate). Sibutramine inhibits platelet uptake ntawm serotonin thiab tuaj yeem hloov cov platelet muaj nuj nqi. Nrog rau qhov kev txo qis hauv lub cev hauv cov ntshav cov ntshav, cov ntsiab lus ntawm HDL nce thiab qhov cov roj (cholesterol) tag nrho, triglycerides, uric acid thiab LDL tsawg dua.

Thaum kho sibutramine, so ntshav tawm me ntsis nce (los ntawm 1-3 hli Hg) thiab cov mem tes maj mam nce (los ntawm 3-7 yeej / me), tab sis qee qhov xwm txheej no cov kev hloov pauv yuav muaj tseeb. Thaum siv sibutramine nrog cov tshuaj tiv thaiv ntawm microsomal oxidation, QT ntu yog ncua (los ntawm 9.5 ms) thiab cov mem tes nce ntxiv (los ntawm 2.5 beats / min).

Kev tshawb fawb hauv cov nas thiab nas cov qog nqaij hlav, mutagenic, teratogenic thiab kev cuam tshuam ntawm sibutramine fertility tsis pom tshwm, qhov tshwm sim ntawm cov qog nqaij hlav ntawm cov nqaij mos ua ntu ntawm cov noob qes nce ntxiv feem ntau ntawm cov nas. Tab sis hauv kev tshawb fawb txog luav hauv cov xeeb leej xeeb ntxwv, kev txawv txav ntawm kev loj hlob ntawm lub cev tau qhia tawm (kev hloov loj lossis duab ntawm tus Tsov tus tw, auricle, muzzle, thiab pob txha tuab).

Thaum noj ntawm qhov ncauj, sibutramine nrawm nrawm rau lub plab zom mov tsawg kawg 77%. Thaum lub sijhawm "thawj hla" los ntawm daim siab, cov tshuaj yog biotransformed nrog kev koom tes ntawm CYP3A4 isoenzyme ntawm cytochrome P450 nrog kev tsim ntawm ob lub zog metabolites (di - thiab monodesmethylsibutramine). Thaum noj 15 mg ntawm cov tshuaj, qhov siab tshaj plaws ntawm monodesmethylsibutramine yog kwv yees li 4 ng / ml, didesmethylsibutramine qhov nruab nrab ntawm 6.4 ng / ml. Qhov siab tshaj plaws ntawm sibutramine yog tiav tom qab 1.2 teev, nws cov metabolites nquag tom qab 3-4 teev. Kev tswj hwm tshuaj ntawm cov tshuaj nrog zaub mov txo qhov kev xav ntau tshaj ntawm cov khoom noj tshuaj tiv thaiv metabolites los ntawm 30% thiab nce lub sijhawm kom ncav cuag nws los ntawm 3 teev, thaum AUC tsis hloov. Qhov sib luag siab hauv cov ntshav ntawm cov metabolites nquag ntawm sibutramine tau tiav hauv 4 hnub tom qab pib kev kho thiab kwv yees li 2 zaug siab dua cov ntsiab lus ntshav tom qab noj ib koob. Sibutramine tau muab faib sai sai thoob plaws cov ntaub so ntswg. Sibutramine khi rau cov ntshav plasma nqaij los ntawm 97%, nws cov metabolites nquag - los ntawm 94%. Ib nrab-lub neej ntawm sibutramine yog 1.1 teev, didesmethylsibutramine - 16 teev, monodesmethylsibutramine - 14 teev. Nquag metabolites yauv mus rau kev sib xyaw thiab lub cev nrog kev tsim cov roj tsis ua haujlwm, uas tsuas yog tawm ntawm lub raum.

Saib xyuas! Txij xyoo 2010, sibutramine thiab kev npaj muaj nws tau raug txwv rau kev muag khoom hauv Tebchaws Europe, Tebchaws Asmeskas, Canada thiab Australia vim yog cov pov thawj kev cuam tshuam ntawm cov kab mob plawv. EMEA pom zoo tias cov kws kho mob tsis tau sau ntau tshaj sibutramine, cov kws muag tshuaj tsis tso nws, thiab cov neeg mob maj mam mus ntsib kws kho mob rau kev hloov pauv ntawm kev kho.

Kev txhawb nqa kev kho mob rau cov neeg mob nyhav dhau los ntawm kev rog rog alimentary nrog lub cev qhov hnyav ntawm 30 kg / m2 lossis ntau dua lossis nrog lub cev qhov ntsuas ntawm 27 kg / m2 lossis ntau dua, tab sis nyob rau ntawm lwm qhov kev pheej hmoo uas cuam tshuam nrog kev hnyav lub cev ( dyslipoproteinemia, hom 2 mob ntshav qab zib mellitus).

Cov Yuav Tsum Muaj

Hypersensitivity, bulimia nervosa lossis anorexia nervosa, muaj cov organic ua rau kev rog, Gilles de la Tourette syndrome, peripheral arterial occlusion kab mob, ntshav tsis ua haujlwm, lub siab tsis ua hauj lwm, mob plawv, mob plawv, mob plawv los ntawm lub plawv, arrhythmia, tachycardia, ntshav siab (ntshav siab tshaj 145 / 90 mmHg), kab mob cerebrovascular (mob cerebrovascular hloov pauv, mob hlab ntsha tawg), qhov tsis zoo ntawm lub xeev kev ua haujlwm ntawm lub raum lossis mob siab, qhov muag coma, hyperthyroidism, pheochromocytoma, benign prostatic hyperplasia, uas yog nrog cov muaj cov zis, tsim cov tshuaj, pharmacological thiab cawv kev vam khom, kev sib faib lossis ib lub sijhawm tsawg dua 2 lub lis piam tom qab tshem tawm ntawm MAO inhibitors lossis lwm yam tshuaj uas ua rau hauv nruab nrab cov hlab ntsha (suav nrog thiab tshuaj tua kab mob tiv thaiv kab mob, tshuaj tua kab mob, tiv thaiv kabmob (tryptophan), thiab lwm yam tshuaj los txo lub cev qhov hnyav.

Cov npe lag luam rau cov tshuaj nrog cov tshuaj sibutramine

Sibutramine, nrog rau nws cov qauv sib xyaw nrog cov txiaj ntsig zoo ntawm lub siab, muaj nyob rau hauv "Cov npe ntawm cov khoom muaj zog rau lub hom phiaj ntawm Tshooj 234 thiab lwm cov ntawv ntawm Lub Cim Txhaum Cai ntawm Lavxias Federation", pom zoo los ntawm tsab cai ntawm tsoomfwv Lavxias Lub Kaum Ob Hlis 29, 2007 N 964. tias txhua daim ntawv muab tshuaj, tsis muaj teeb meem dab tsi (cov lag luam) cov npe uas lawv tau xaiv, uas suav nrog cov tshuaj nyob hauv cov npe no ua ke nrog cov tshuaj tiv thaiv kev tsis sib haum xeeb, kuj muaj nyob hauv qhov qhia th daim ntawv teev. Hauv tebchaws Russia, cov tshuaj no tuaj yeem raug cai yuav nrog cov kws kho mob sau ntawv thiab tsuas yog hauv cov khw muag tshuaj yog tias lawv muaj ntawv tso cai rau cov haujlwm muaj cai nrog kev ua haujlwm nrog cov muaj zog thiab cov tshuaj muaj kuab lom, raws li PKKN cov npe.

Kev kawm txog kev noj tshuaj raws cov tshuaj sibutramramine

Sibutramine rau kom poob phaus yuav tsum noj kom nruj raws li cov lus qhia. Cov neeg tsim tshuaj ntawm cov tshuaj tau thov tias kom npuaj qab los noj mov, nws txaus los noj 10 mg ntawm sibutramine ib hnub. Nyob rau tib lub sijhawm, lawv pom zoo kom txo qis ntawm cov calories kom txhua hnub 20% thiab ua cov kev tawm dag zog ob peb zaug hauv ib lub lim tiam.

Lub chav kawm ntawm kev noj nyiaj txiag raws li cov tshuaj yeeb dej caw no yog ntev - los ntawm peb mus rau rau lub hlis, nyob rau qee kis nws tuaj yeem ua ib xyoos. Kev siv cov sibutramine ua tau tsuas yog hauv qhov xwm txheej uas tus neeg mob tsis tuaj yeem yuag poob nrog kev pab los ntawm kev ua kom muaj zog thiab noj haus. Feem ntau, ua ntej sau cov tshuaj uas txhim kho cov serotonin, cov neeg mob tau muab tso rau kev noj zaub mov, saib nws rau qee lub sijhawm. Yog tias qhov hloov pauv hauv kev noj zaub mov tsis zoo rau qhov poob phaus, ib yam tshuaj nrog sibutramine tau raug txwv.

Dab tsi yog sibutramine txaus ntshai: phiv thiab phiv

Sibutramine rau kom poob phaus yog ib qho yeeb tshuaj zoo, txawm li cas los xij, hauv ntau qhov kev soj ntsuam, kev poob phaus cov ntxhais thiab cov kws kho mob hu rau cov tshuaj yeeb dej caw no thiab cov tshuaj muaj zog. Cov tuam ntxhab ntawm cov khoom lag luam tshuaj no hauv txhua txoj hauv kev tsis kam lees cov ntaub ntawv no thiab faib cov sibutramine tsis raug cai raws ntau cov npe lag luam.

Qhov tsis zoo ntawm sibutramine yog dab tsi thiab nws puas muaj kev cuam tshuam tsis zoo rau tib neeg lub cev? Muab qhov tseeb tias cov tshuaj nquag muaj feem cuam tshuam rau lub hlwb, qhov kev phom sij ntawm txoj hau kev ntawm qhov kev poob phaus ua tau.Ntawm cov kev phom sij tshaj plaws ntawm cov sibutramine, cov kws tshaj lij hu tias tsis ua haujlwm ntawm lub siab thiab lub siab ntsws. Cov kev phom sij thiab tsis txaus ntseeg ntawm cov khoom lag luam pharmacological nrog xws li muaj pes tsawg leeg tau lees paub qhov tseeb tias nws tau txwv hauv ntau lub tebchaws European.

Sibutramine tau raug tsim tawm thaum chiv thawj coj los siv ua kev daws teeb meem rau kev nyuaj siab, tab sis hmoov tsis, nws tsis tau txais qhov tshwm sim zoo. Tab sis thaum qhov kev sim, nws lub peev xwm ua rau nws tsis qab los noj mov tau pom. Txij thaum ntawd, sibutramine tau siv los ua. Muaj ntau lub tebchaws uas txwv tsis pub muag cov tshuaj. Yog li ntawd, kev xa mus rau cov teb chaws CIS tau raug muab ncua tseg.

Kev siv cov tshuaj muaj feem cuam nyob rau hauv rooj plaub thaum lwm txoj hauv kev rau qhov poob phaus tsis muab cov nyhuv. Sibutramine nyiam dua yog siv nrog kev noj zaub mov noj lossis ua kom lub cev qoj ib ce. Yog li nws yuav coj ntau dua:

• Npub qab los noj mov
• Nquag tawg los ntawm lub cev rog,
• Kev ua kom muaj ntau lawm ntawm serotonin, uas pab ua kom zoo mloog,
• Txo txo ​​salivation thiab lub peev xwm los tsim caries,
• Kev muaj txiaj ntsig zoo, kev poob phaus ntawm 7 txog 15 kg ib hlis.

Yuav hloov cov sibutramine li cas

Tshuaj rau qhov poob phaus: