Tshuaj tua kab mob Bayer Avelox > Kev khomob thiab kev tiv thaiv

Kev txais tos rau koj!

Avelox tau raug sau tseg rau kuv los ntawm kws kho mob poj niam, yog li tus txiv neej tej zaum zoo dua txhua yam uas tau sau hauv qab no, nws zoo dua tsis txhob nyeem.

Ob xyoos dhau los, Kuv twb sau ntawv txheeb xyuas ntawm lub ncauj lus "Kuv muaj qhov tsw phem"yog li ntawd kuv tau muab haujlwm:

Tom qab ntawd kuv tau raug kev txom nyem: kev kho mob tsis tau muab cov txiaj ntsig tam sim ntawd. Thiab lub sijhawm no nws yuav luag zoo li qub.

Kuv tsis paub dab tsi tshwm sim rau kuv lub cev, tab sis cov teeb meem ntawm qhov tsis hnov tsw yog tsa cov ntshav dawb -

xyuas kuv dua xyoo no. Thiab nws zoo li tsis muaj dab tsi raug mob, tsuas muaj qee qhov tsis xis nyob, uas yuav luag txhua zaus muaj xws li.

Feem ntau, Kuv yog tus nquag saib xyuas tus kws khomob rau tus pojniam: kev kuaj mob ultrasound 2 zaug hauv ib xyoos thiab kev sab laj sab laj ntawm tus kws kho mob pojniam-endocrinologist. Qhov tseeb yog tias qhov mob kuv tau ntev ntev yog endometrial hyperplasia.

Tsis ntev los no, Kuv pom tau tias nws yog endometrial hyperplasia uas tuaj yeem ua rau dhia hauv leukocytes hauv qhov pleev - vim tias foci ntawm endometrium yeej ib txwm muaj nyob hauv lub tsev menyuam.

Tus kws kho mob hais rov qab ua ib qho kev phais mob, tab sis kev sim "zoo" yog qhov tsim nyog rau txoj kev ua no. Txhawm rau ua qhov no, Kuv tau raug tsim kho thawj zaug tswm ciab, thiab tom qab ntawd - thaum kuv tau mus ntsib kws kho mob ib zaug ntxiv, tshuaj tua kab mob.

Tus kws kho mob poj niam ua ntej tshaj tawm tswm ciab Fluomizinum tswm ciab.

Tab sis lawv txoj kev kho mob, txawm hais tias nws zoo nyob, tsis txhim kho cov txiaj ntsig ntawm kev pleev, - raws li kws kho mob, nws haj yam tsis zoo.

Raws li tus kws kho mob poj niam, Kuv tsis paub tias nws tau coj ua dab tsi - tom qab ntawd, Kuv tsis muaj kev txhawm rau qhov tshwm sim los ntawm ultrasound - nws tau siv tshuaj tua kab mob tshiab uas muaj zog tshaj plaws - Avelox.

Txhawb kuv tias "nws yeej yuav pab tam sim ntawd!", ntxiv rau kuv ntau ntau cov tshuaj uas yuav tiv thaiv qhov pom ntawm dysbiosis thiab thrush.

Feem ntau, kuv txoj kev kho tau ib lub penny!

Ua ntej noj avelox Kuv, zoo li ib txwm nyeem cov kev txheeb xyuas, los ntawm qhov nws tau paub meej tias kuv lub cev tuaj yeem hloov pauv Avelox, raws li kuv muaj teeb meem nrog lub zais zis, thiab qhov ntawdqhov no txhais tauyuav luag txhua yam kab mob pab.

Thov

Kuv coj Avelox 1 ntsiav tshuaj ib hnub tom qab noj mov, ntxuav nrog dej rau 2 lub lis piam.

Kuv sim tsis hloov lub sij hawm noj mov kom tsis muaj kev thauj khoom tsis sib xws nyob rau ntawm lub cev.

Cov Khoom Qhia

Cov kab mob sib kis thiab mob kis rau cov neeg laus los ntawm cov kab mob me me nkag siab rau cov tshuaj: mob ntsws mob sai, zej zog muaj mob ntsws (nrog rau cov mob tshwm sim los ntawm cov kab mob ntau yam nrog cov tshuaj tiv thaiv kab mob), ua kom mob ntsws, mob tsis yooj yim rau cov tawv nqaij thiab cov nqaij mos, ua rau mob tawv nqaij thiab subcutaneous. kev teeb tsa (suav nrog rau mob ko taw mob ntshav qab zib), mob nyuaj ntawm lub plab, nrog rau cov kab mob polymicrobial, suav nrog intraperitoneal abscesses, tsis mob tus kab mob ntawm lub plab hu ua (suav nrog rau salpingitis thiab endometritis).

Cov Yuav Tsum Muaj

cev xeeb tub, lactation (pub niam mis),
cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo,
hypersensitivity rau moxifloxacin thiab lwm yam tshuaj ntawm cov tshuaj.

Sab sij huam

Ua kom ntev ntawm QT luv (feem ntau hauv cov neeg mob concomitant hypokalemia, qee zaum hauv lwm tus neeg mob), tachycardia thiab vasodilation (tso dej tawm ntawm lub ntsej muag), arterial hypotension, arterial hypertension, tsaus muag, ventricular tachyarrhythmias, nonspecific arrhythmias (suav nrog extrasystole), polymorphic ventricular (ventricular pirouette hom arrhythmia) lossis mob plawv feem ntau nyob rau hauv cov neeg uas muaj mob predisposing rau arrhythmias, xws li thaj chaw tseem ceeb bradycardia, mob myocardial ischemia, ua tsis taus pa, nrog rau ac lej, xeev siab, ntuav, mob plab, raws plab, anorexia, cem quav, dyspepsia, flatulence, mob plab (tshwj tsis yog mob rau daim tawv nqaij), stomatitis, pseudomembranous colitis (feem ntau tsis tshua muaj feem cuam tshuam nrog kev phom sij txog lub neej), daj ntseg, kab mob siab (feem ntau cholestate ), kiv taub hau, mob taub hau, tsis meej pem, tsis meej pem, tsaug zog, tshee tshee, pw tsaug zog, ntxhov siab, muaj lub zog psychomotor, muaj kev sib koom ua ke (suav nrog kev cuam tshuam vim kiv taub hau Kuv, nyob rau qee qhov xwm txheej tsawg, ua rau muaj kev raug mob los ntawm qhov poob, tshwj xeeb tshaj yog rau cov neeg mob laus), qaug dab peg nrog ntau cov chaw kuaj mob (suav nrog qaug dab peg cov neeg txiv), tsis hnov qab, hais lus tsis meej, tsis nco qab, muaj kev nyuaj siab (feem ntau tsis zoo, coj tus cwj pwm ua rau tus kheej raug mob yog qhov ua tau), pom kev tsis meej, puas siab puas ntsws (muaj qhov tshwm sim hauv tus cwj pwm nrog kev nyiam tus kheej), saj tsis meej, pom kev tsis xws luag (qhov muag plooj, tsis pom qhov tseeb, diplopia, tshwj xeeb tshaj yog nyob rau hauv ua ke nrog kiv taub hau thiab tsis meej pem), tinnitus, ua txhaum ntawm tsis hnov tsw, suav nrog anosmia, poob ntawm saj rhiab heev, anemia, leukopenia (suav nrog neutropenia), thrombosis cytopenia, thrombocytosis, lub caij nyoog prothrombin ntev thiab tsawg dua INR, mob pob txha caj qaum, mob leeg ntshav siab, leeg ntshav nrog, mob raum, mob raum, leeg ntshav tawg, lub cev tsis muaj zog, vaginitis, lub cev qhuav dej (vim los ntawm kev mob plab zom mov lossis nqos dej tsawg), lub raum tsis ua haujlwm, lub raum tsis ua haujlwm vim yog lub raum tsis ua haujlwm. , uas tuaj yeem ua rau lub raum puas tsuaj (tshwj xeeb tshaj yog nyob rau cov neeg laus cov neeg laus uas muaj lub raum tsis pom kev zoo), cov tawv nqaij tawv nqaij tsis zoo, piv txwv li, Stevens-Johnson syndrome lossis lom cov tshuaj tiv thaiv mob (cov mob uas ua rau tuag taus), urticaria, pruritus, tawm pob, eosinophilia, anaphylactic / anaphylactoid tshua, angioedema, suav nrog laryngeal edema (muaj feem yuav txo tau txoj sia), anaphylactic poob siab (suav nrog lub neej tsis txaus siab), hais qhov tsis meej (xam nrog rau cov tsos mob ntawm kev noj qab haus huv tsis zoo, mob tsis xws luag thiab tawm hws), o.

Muaj pes tsawg leeg

Cov tshuaj tseem ceeb: moxifloxacin hydrochloride - 436,8 mg

Tsos

Cov ntsiav tshuaj, raws li koj tuaj yeem pom, yog tus loj, tab sis ua tsaug rau lawv lub ntsej muag zoo lawv tau haus cawv ntau zaus.

Dosage daim ntawv

400 mg zaj duab xis-coated ntsiav tshuaj

Ib ntsiav tshuaj muaj

akcov tshuaj nquag - moxifloxacin hydrochloride 436,8 mg,

(sib piv rau moxifloxacin 400.0 mg),

tus zam: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate,

plhaub muaj pes tsawg leeg: hlau oxide liab, hypromellose, macrogol 4000, titanium dioxide.

Cov ntsiav tshuaj xim kub ntev ntev, xim txheej, ntev li 17 hli thiab ntev li 7 hli, cim “M 400” ntawm ib sab thiab “BAYER” ntawm lwm qhov.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Xuas thiab bioavailability

Thaum noj ntawm qhov ncauj, moxifloxacin yog nqus sai thiab yuav luag txhua yam. Kev tsis raug cai ntawm qhov tsis raug cai yog txog 91%.

Cov tshuaj pharmacokinetics ntawm moxifloxacin thaum noj ntawm koob 50 rau 1200 mg ib zaug, nrog rau 600 mg / hnub rau 10 hnub, yog kab. Lub xeev kev sib luag yog mus txog hauv 3 hnub.

Tom qab txhaj ib koob tshuaj 400 mg ntawm moxifloxacin, qhov siab tshaj plaws (C max) hauv cov ntshav tau mus txog hauv 0.5-4 teev thiab yog 3.1 mg / l. Peak thiab yam tsawg kawg ntshav ntshav ntau nyob hauv lub xeev ruaj khov (400 mg ib hnub ib zaug) yog 3.2 thiab 0.6 mg / L, raws.

Thaum noj moxifloxacin nrog zaub mov, muaj lub sijhawm nce siab me ntsis mus txog Cmax (los ntawm 2 teev) thiab txo qis me ntsis hauv Cmax (los ntawm kwv yees li 16%), thaum lub sijhawm ntev ntawm kev nqus tsis hloov. Txawm li cas los xij, cov ntaub ntawv no tsis muaj qhov tseem ceeb hauv kev kho mob, vim tias qhov AUC / MIC piv ntau kwv yees cov kev ua haujlwm ntawm quinolones. Yog li, cov tshuaj yuav siv tau tsis hais txog ntawm cov zaub mov noj.

Moxifloxacin yog xa tawm sai heev hauv lub txaj extravascular. Muaj thaj chaw loj nyob hauv qab ntawm AUC pharmacokinetic nkhaus (AUCnorm = 6 kg * teev / L) nrog qhov sib npaug faib ntim (Vss) ntawm moxifloxacin kwv yees li 2 L / kg. Qhov siab tshaj plaws ntawm moxifloxacin hauv cov qaub ncaug muaj siab dua hauv ntshav. Hauv kev tshawb fawb hauv vitro thiab hauv vivo hauv cov ntsiab lus thaj tsam li ntawm 0.02 txog 2 ml / l, kev sib khi ntawm moxifloxacin mus rau cov nqaijrog yog kwv yees li 45%, tsis hais txog kev mloog tshuaj.

Moxifloxacin yog feem ntau cuam tshuam nrog ntshav albumin.

Muaj lub siab siab kawg hauv kev siab tsis meej> 10xMIC vim tsawg ntim.

Cov tshuaj muaj zog ntau dhau ntawm cov tshuaj, dhau ntawm cov hauv plasma, raug tsim nyob rau hauv lub ntsws (cov kua epithelial, alveolar macrophages, cov nqaij mos), hauv cov hlab ntsha thiab polyps, hauv foci ntawm o. Hauv cov qaub ncaug, cov kua dej ua kua (intermuscular thiab subcutaneous), qhov siab ntawm cov tshuaj hauv lub xeev dawb yog txiav txim siab.

Tsis tas li ntawd, ntau qhov ntau ntawm cov tshuaj tau txiav txim siab hauv cov kabmob ntawm lub plab thiab lub plab peritoneal, zoo li hauv cov poj niam lub cev.

Tom qab ib koob tshuaj moxifloxacin 400 mg, ntawm ob qho kev khiav ntawm kev tswj hwm, kev sib piv siab tshaj plaws tau pom tau muab piv rau cov ntshav plasma feem ntau ntawm cov phiaj nqaij.

Tom qab dhau lub sijhawm thib ob ntawm biotransformation, moxifloxacin raug ntiab tawm ntawm lub cev los ntawm lub raum thiab lub plab zom mov (GIT) ob qho tib si tsis hloov thiab hauv daim ntawv ntawm cov tsis muaj zog sulfo teb (M1) thiab glucuronides (M2). Cov metabolites no muaj feem xyuam rau tib neeg lub cev thiab tsis muaj cov haujlwm antimicrobial. Kev kawm txog kev sib cuam tshuam ntawm cov tshuaj pharmacokinetic nrog lwm cov tshuaj tau pom tias moxifloxacin tsis yauv biotransformation los ntawm microsomal cytochrome P450 system.

Tsis hais txog ntawm cov txheej txheem ntawm daim ntawv thov, cov metabolites M1 thiab M2 pom nyob rau hauv cov ntshav ntshav ntawm qhov kev txiav txim siab qis dua qhov kev suav ntawm moxifloxacin tsis hloov.

Ib nrab-lub neej ntawm cov tshuaj los ntawm cov ntshav yog kwv yees li 12 teev. Qhov nruab nrab tag nrho kev tshem tawm tom qab noj ib koob ntawm 400 mg yog los ntawm 179 txog 246 ml / min. Kev hlais hlais tawm ntawm kwv yees li 24-53 ml / min tshwm sim los ntawm ib nrab ntawm cov leeg rov ua dua ib feem ntawm cov tshuaj hauv lub raum. Kev siv tshuaj sib xyaw nrog ranitidine thiab probenecid tsis cuam tshuam rau lub raum uas tshem tawm cov tshuaj. Tsis hais txog txoj kev ntawm txoj kev tswj hwm, pib cov khoom siv moxifloxacin yuav luag tiav 96-98% kev hloov pauv rau cov tshuaj tiv thaiv ntawm theem ob ntawm cov metabolism tsis muaj cov cim ntawm oxidative metabolism.

Pharmacokinetics hauv ntau pab pawg neeg mob

Cov sib txawv hauv cov chaw muag tshuaj ntawm moxifloxacin tsis tau tsim.

Paul Qhov sib txawv (33%) hauv pharmacokinetics (AUC, Cmax) ntawm cov txiv neej thiab poj niam tau tshwm sim. Cov kev qhia tawm sib txawv hauv AUC thiab Cmax tau piav qhia los ntawm qhov sib txawv ntawm lub cev qhov hnyav dua li los ntawm poj niam txiv neej. Yog li, lawv tsis yog qhov tseem ceeb hauv tsev kho mob.

Cov kev cuam tshuam sib txawv li cas tau kawm txog Caucasoid, Japanese, Negroid, thiab lwm haiv neeg. Clinically qhov sib txawv tseem ceeb hauv cov chaw muag tshuaj ntawm moxifloxacin tseem tsis tau tsim.

Cov tshuaj pharmacokinetics ntawm moxifloxacin hauv cov menyuam yaus tsis tau kawm.

Tsis muaj cov kev hloov pauv tseem ceeb hauv cov chaw muag tshuaj ntawm moxifloxacin hauv cov neeg mob uas lub raum tsis ua haujlwm (suav nrog cov neeg mob creatinine ntawm 1/100 thiab 1/1000 thiab 1/10 0000 thiab /1 / 1,000)

- kev hloov pauv ntawm thromboplastin concentration

- anaphylactic / anaphylactoid kev tsis haum, kev ua xua / angioedema, suav nrog cov laryngeal edema (muaj feem ua rau tuag taus)

- lub siab lub zog, kev nyuaj siab (hauv qhov tsis tshua muaj tshwm sim, muaj qhov tshwm sim hauv tus cwj pwm nrog tus cwj pwm ntawm tus kheej, xws li xav tua tus kheej lossis npaj siab), pom kev zoo

- hyposthesia, ua txhaum ntawm tsis hnov tsw, suav nrog anosmia

- npau suav pathological, kev tsis muaj kev sib koom ua ke (suav nrog kev ua tsis tau zoo, feem ntau vim yog kiv taub hau lossis mob loj dua (ua rau ntog raug mob, tshwj xeeb yog cov neeg laus hauv cov neeg mob tsawg)), qaug dab peg nrog ntau qhov chaw kuaj mob (suav nrog cov dav dav), tsis hnov qab, hais lus tsis meej, tsis nco qab

- peripheral neuropathy thiab polyneuropathy

- tinnitus, hnov lus tsis zoo, suav nrog lag ntseg (feem ntau thim rov qab)

- tsaus muag, hypotension, kub siab, ventricular tachyarrhythmias

- dysphagia, stomatitis, pseudomembranous colitis (cuam tshuam nrog kev phom sij txog lub neej txoj sia ntawm qee qhov tsawg), daj ntseg, tawv nqaij (feem ntau cholestatic)

- mob leeg, mob leeg nruj thiab mob plab, mob leeg

- lub raum tsis zoo, lub raum tsis ua haujlwm (vim yog lub cev qhuav dej, tshwj xeeb tshaj yog rau cov neeg laus laus uas muaj lub raum tsis ua haujlwm)

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Avelox yog muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated thiab ib qho kev daws teeb meem.

Cov tshuaj yeeb dej caw yog moxifloxacin: hauv 1 ntsiav tshuaj thiab 250 ml ntawm kev daws - 400 mg.

Tshwj xeeb ntawm cov ntsiav tshuaj: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, daj hlau oxide, macrogol 4000, titanium dioxide.

Lub Cheebtsam cov haujlwm ntawm kev daws: 1M hydrochloric acid, sodium chloride, 2M sodium hydroxide tov, dej rau kev txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Moxifloxacin (npe tshuaj lom neeg - 8-methoxyfluoroquinolone) yog cov tshuaj tua kab mob ua kom dav ntxiv. Nws cov nyhuv bactericidal vim yog qhov tseeb tias nws yog ib qho inhibitor ntawm cov kab mob topoisomerases II thiab IV. Qhov no ua rau muaj kev ntxhov siab nyob rau hauv cov txheej txheem ntawm kev hloov pauv, kho thiab rov ua dua ntawm DNA biosynthesis ntawm microbial hlwb thiab, vim li ntawd, ua rau kev tuag ntawm tom kawg.

Tsawg kawg ntawm cov kab mob bactericidal ntau ntawm moxifloxacin feem ntau piv rau qhov muaj kev txwv tsawg kawg. Avelox cov haujlwm tiv thaiv tsis yog txiav txim siab los ntawm cov txheej txheem uas ua rau kev txhim kho kev tiv thaiv ntawm tetracyclines, penicillins, macrolides, aminoglycosides thiab cephalosporins. Kab mob sib kis ntawm cov tshuaj no ntawm cov tshuaj tua kab mob thiab moxifloxacin tsis pom. Cov kab mob plasmid tsis kam tam sim no tsis tau sau npe. Zuag qhia tag nrho cov kev tshwm sim ntawm kev tawm tsam yog qhov tsawg kawg (10 -7 ‒10 -10).

Kev tawm tsam rau Avelox kev loj hlob dhau lub sijhawm ntev dhau los ntawm ntau yam kev sib hloov.

Rov ua dua rau tus txheej txheem nquag ntawm Avelox hauv kev kub siab uas tsis ncav tus nqi ntawm qhov tsawg kawg nkaus inhibitory concentration (MIC), ua rau tsuas yog nce me ntsis hauv MIC.

Muaj qee kis ntawm tus ntoo khaub lig-tiv taus rau quinolones. Txawm li cas los xij, qee qhov anaerobic thiab gram-zoo cov kab mob tsis haum nrog lwm cov quinolones muaj kev cuam tshuam zoo rau moxifloxacin.

Nws tau tsim muaj ntxiv tias qhov sib ntxiv ntawm cov pab pawg methoxy hauv ib cheeb tsam ntawm txoj haujlwm C8 rau moxifloxacin cov qauv molecular nce nws cov haujlwm thiab tiv thaiv kev tsim cov kev hloov pauv ruaj khov ntawm cov kab mob gram-positive.

Qhov sib ntxiv ntawm pab pawg bicycloamine mus rau molecule ntawm txoj hauj lwm C7 tiv thaiv qhov tsim ntawm efflux nquag thiab cov txheej txheem ntawm kev ua haujlwm ntawm fluoroquinolones.

Hauv vitro moxifloxacin ua haujlwm tawm tsam ntau ntawm cov kab mob gram-positive thiab gram-tsis zoo, anaerobes, kab mob atypical thiab kua qaub-tiv thaiv kab mob (e.g. Legionella spp., Chlamydia spp., Mycoplasma spp.), Thiab cov kab mob sib kis zoo rau cov tshuaj macrolide thiab β-lactam.

Lub sijhawm no, ob txoj kev tshawb fawb nrog cov neeg ua haujlwm pab dawb tau paub hauv kev hloov pauv hauv plab hnyuv microflora tom qab kev tswj hwm qhov ncauj ntawm moxifloxacin tau kawm. Lawv pom qhov kev txo qis ntawm cov ntau ntawm Klebsiella spp., Escherichia coli, Enterococcus spp., Bacteroides vulgates, Bacillus spp., Raws li zoo li anaerobes Peptostreptococcus spp., Eubacterium spp., Bifidobacterium spp. Cov kev hloov no tau thim rov qab rau ob lub lis piam. Clostridium difficile cov taug kuj tsis pom meej.

Hauv vitro moxifloxacin ua kom pom cov kab mob siab tiv thaiv cov kab mob hauv qab no:

Cov kab mob Gram-positive: Gardnerella vaginalis, methicillin-rhiab cov kab mob ntawm coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S.hominis, S. haemolyticus), Staphylococcus aureus (hom kab mob tau ntxim rau methicillin), Streptococcus pneumoniae nrog rau cov tshuaj tiv thaiv penicillin, thiab cov kab mob uas muaj ntau yam tshuaj tua kab mob, nrog rau cov kab uas tiv taus ob lossis ntau dua tshuaj tua kab mob, uas suav nrog trimethoprim / sulfamethoxazole, penicillin (MIC ntau tshaj 2 μg / ml), tetracyclines, cephalosporins thib ob tiam (e. cefuroxime), macrolides, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus pyrogenes pawg A, v vidididaida v. , S. thermophilus, S. mutans, S. sa livarius, S. sanguinis, S. mitis), pawg Streptococcus milleri (S. intermedins, S. constellatus, S. anginosus),
cov kab mob g-tsis zoo: Proteus vulgaris, Haemophilus parainfluenzae, Haemophilus influenzae (suav nrog cov kab mob ua ke thiab tsis coj los ua ke β-lactamases), Acinetobacter baumannii, Moraxella catarrhalis (suav nrog cov kab mob uas tsim thiab tsis ua kua β-lactamases, Bordella.
anaerobic microorganisms: Propionibacterium spp., Fusobacterium spp., Prevotella spp., Porphyromonas spp.,
atypical microorganisms: Coxiella burnetii, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae.

Cov kab mob me me hauv qab no yog mob moxifloxacin:

Cov kab mob gram-positive: Enterococcus faecium, Enterococcus avium, Enterococcus faecalis (tshwj xeeb mob rau gentamicin thiab vancomycin),
cov kab mob gram-tsis zoo: Providencia spp. (P. stuartii, P. rettgeri), Escherichia coli, Neisseria gonorrhoeae, Klebsiella oxytoca, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Proteus mirabilis, Enterobacter spp. (E. sakazakii, E. intermedius, E. aerogenes), Enterobacter cloacae, Stenotrophomonas maltophilia, Burkholderia cepacia, Pseudomonas fluorescens, Pantoea agglomerans,
cov kab mob anaerobic: Clostridium spp., Peptostreptococcus spp., Bacteroides spp. (B. vulgaris, B. fragilis, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron).

Cov kab mob me me hauv qab no qhia kev tawm tsam cov tshuaj:

cov kab mob gram-positive: methicillin-resistant hom ntawm coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. hominis, S. haemolyticus), ofloxacin / methicillin-resistant hom ntawm Staphylococcus aureus,
Cov kab mob gram-negative: Pseudomonas aeruginosa.

Kev siv Avelox tsis pom zoo rau kev kho mob los ntawm kev kis mob los ntawm kab mob ntawm Staphylococcus aureus nrog cov paub tseeb tias nws tsis kam nrog methicillin (MRSA). Yog hais tias muaj tus mob MRSA kho, kev kho mob nrog cov tshuaj tua kab mob tsim nyog yuav tau kho.

Rau qee hom kab mob, kis tau kuj yuav kis sib txawv raws sijhawm thiab nyob ntawm thaj chaw ntawm cov neeg mob. Vim li no, thaum kuaj mob muaj mob rhiab heev, nws raug nquahu kom kawm cov ntaub ntawv hauv zos txog kev tiv thaiv, tshwj xeeb hauv kev kho mob kis mob hnyav.

Yog hais tias nyob rau hauv cov neeg mob raug kho hauv tsev kho mob, tus nqi ntawm thaj chaw hauv qab cov kab muag tshuaj pharmacokinetic "xav txog - sijhawm" (AUC) / MIC₉₀ yog ntau tshaj 125, thiab cov ntsiab lus siab tshaj plaws ntawm moxifloxacin hauv ntshav ntshav (C_max) / MIC₉₀ yog nyob rau hauv thaj tsam ntawm 8-10, qhov no txhais tau tias muaj txiaj ntsig zoo thiab kev txhim kho hauv kev kho mob ntawm tus neeg mob. Hauv cov neeg mob sab nrauv, cov kev ntsuas no feem ntau tig los tsawg dua (AUC / MIC₉₀ ntau tshaj 30-40).

Thaum noj qhov ncauj ntawm Avelox: nrog MIC nruab nrab₉₀ 0.125 mg / ml AUIC (thaj chaw hauv qab nkhaus, i.e. AUC / MIC piv₉₀) yog sib npaug 279, thiab C_max/ TSWV₉₀ - 23.6. Nrog MIC cov txiaj ntsig₉₀ 0.25 mg / ml thiab 0.5 mg / ml AUIC thiab C qhov tseem ceeb_max/ TSWV₉₀ yog feem 140 thiab 11.8 hauv thawj kis thiab 70 thiab 5.9 hauv rooj plaub thib ob.

Nrog txoj kev lis ntshav: nrog MIC nruab nrab₉₀ 0.125 mg / ml AUIC yog 313 thiab C_max/ TSWV₉₀ - 32,5. Nrog MIC cov txiaj ntsig₉₀ 0.25 mg / ml thiab 0.5 mg / ml AUIC thiab C qhov tseem ceeb_max/ TSWV₉₀ yog feem 156 thiab 16.2 hauv thawj kis thiab 78 thiab 8.1 hauv rooj plaub thib ob.

Cov Tshuaj Pharmacokinetics

Thaum noj Avelox sab hauv, moxifloxacin yog nqus ntawm qhov kev kub ceev thiab yuav luag tag. Nws lub peev xwm txog ntawm bioavailability yog kwv yees li 91%. Nws yog qhov tseeb tias lub khw muag tshuaj ntawm cov tshuaj no nrog ib koob tshuaj nyob rau hauv thaj tsam ntawm 50-1200 mg, ntxiv rau qhov kev noj tshuaj ntawm Avelox hauv ib hnub ntawm 600 mg rau 10 hnub, yog kab. Lub xeev kev sib luag yog tsim nyob rau hauv 3 hnub.

Tom qab txhaj ib koob ntawm 400 mg ntawm Avelox, qhov siab tshaj plaws nyob rau hauv cov ntshav tau tiav hauv 0.5-4 teev thiab yog 3.1 mg / l. Nrog kev tswj hwm qhov ncauj ntawm 400 mg ntawm cov tshuaj ib hnub ib zaug, qhov ntau thiab tsawg tshaj plaws nyob ruaj ruaj ntawm cov tshuaj hauv cov ntshav yog 3.2 mg / L thiab 0.6 mg / L, feem. Thaum moxifloxacin tau txais hauv sab hauv nrog cov zaub mov, muaj qhov tsis txaus ntseeg nyob rau lub sijhawm kom ncav ntau qhov siab tshaj (txog 2 teev) thiab ib qho tsis txaus ntseeg ntawm qhov siab tshaj plaws (txog 16%). Hauv qhov no, lub sijhawm ntawm kev nqus yuav tsis hloov pauv. Txawm li cas los xij, cov ntaub ntawv no tsis muaj qee yam tseem ceeb hauv kev kho mob, yog li Avelox raug tso cai thov tsis hais txog kev noj zaub mov.

Tom qab ib zaug tshuaj ntawm Avelox ntawm koob tshuaj 400 mg rau 1 teev, qhov siab tshaj plaws ntawm cov tshuaj tau mus txog thaum xaus ntawm Txoj kev lis ntshav thiab muaj kwv yees li 4.1 mg / l, uas sib raug rau qhov nce ntxiv ntawm kwv yees li 26% piv nrog tus nqi ntawm qhov ntsuas no nrog qhov ncauj tswj hwm ntawm moxifloxacin.

Kev cuam tshuam ntawm moxifloxacin, uas yog txiav txim siab los ntawm AUC qhov ntsuas, me ntsis dhau ntawm kev tswj hwm qhov ncauj ntawm moxifloxacin. Kev tsis raug cai ntawm qhov tsis raug cai yog txog 91%. Tom qab rov ua kom tso cov tshuaj mob ntshav ntawm Avelox ntawm ib koob ntawm 400 mg kawg ntev li 1 teev 1 teev nyob rau ib hnub, qhov ntau thiab tsawg kawg nyob ruaj ruaj moxifloxacin nyob rau hauv cov ntshav sib txawv ntawm thaj tsam ntawm 4.1-5.9 mg / l thiab 0.43-0.84 mg / l, ntsig txog. Qhov ntsuas nruab nrab ruaj khov ntawm 4.4 mg / L yog ua tiav thaum xaus ntawm Txoj kev lis ntshav.

Cov tshuaj tau muab faib sai sai hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg. Nws cov qib kev khi rau cov ntshav protein (feem ntau albumin) yog kwv yees li 45%. Qhov ntim ntawm cov xa mus txog kwv yees li 2 l / kg.

Cov ntsiab lus tseem ceeb ntawm moxifloxacin, ntau dua cov neeg hauv cov ntshav ntshav, tau sau cia hauv cov foci ntawm cov tawv nqaij (cov qhov txhab ua rau tawv nqaij), mob ntsws (nrog rau alveolar macrophages thiab cov kua dej epithelial), qhov ntswg polyps thiab hlab ntshav (ethmoid thiab maxillary sinuses). Hauv cov qaub ncaug thiab cov kua dej interstitial, cov nquag ua haujlwm ntawm Avelox yog txiav txim siab nyob rau hauv nws daim ntawv dawb (tsis muaj khi rau cov protein) thiab nyob rau hauv ntau dua li cov ntshav ntshav. Tsis tas li ntawd, muaj theem siab ntawm moxifloxacin yog pom nyob hauv poj niam lub cev, nrog paim thiab cov nqaij hauv lub plab ua haujlwm.

Moxifloxacin koom nrog cov txheej txheem ntawm biotransformation ntawm theem ob thiab raug tawm hauv lub cev nrog rau cov zis thiab cov quav. Ntxiv mus, nws pom ob qho tib si hauv kev hloov pauv thiab hauv daim ntawv ntawm sulfo tebchaw (M1) thiab glucuronides (M2), uas tsis muaj cov haujlwm pharmacological.

Cov tshuaj tsis muaj feem xyuam nrog kev siv tshuaj biochemical vim raug rau microsomal system ntawm cytochrome P₄₅₀Cov. Plasma ntau ntawm M1 thiab M2 metabolites yog qis dua cov ntawm niam txiv cov khoom sib txuas. Cov txiaj ntsig ntawm cov kev tshawb fawb pom tau hais tias tsis muaj qhov cuam tshuam zoo ntawm cov metabolites hauv lub cev ntawm qhov lawv ua siab ntev thiab muaj kev nyab xeeb.

Ib nrab-lub neej ntawm moxifloxacin yog kwv yees li 12 teev. Qhov nruab nrab, tag nrho kev ua kom pom kev pom tseeb tom qab kev saib xyuas ntawm cov tshuaj hauv ib koob ntawm 400 mg yog 179-246 l / min. Kev kho kom lub npoo rov qab ncav cuag li 24-53 ml / min. Qhov no ua pov thawj rau qee qhov rov qab tubular rov kho ntawm qhov quav.

Qhov loj tshuav ntawm moxifloxacin thiab theem 2 metabolites yog kwv yees li 96-98%, uas ua pov thawj qhov tsis muaj oxidative metabolism hauv. Kwv yees li 22% ntawm kev txhaj tshuaj ib zaug ntawm Avelox (400 mg) yog pom tsis hloov hauv cov zis, thiab kwv yees li 26% nrog quav.

Thaum kawm cov pharmacokinetics ntawm moxifloxacin hauv cov txiv neej thiab poj niam cov neeg mob, AUC thiab qhov ntau ntau tau sib txawv los ntawm kwv yees li 33%. Qhov nqus ntawm cov khoom tsis yog nyob ntawm poj niam txiv neej. Qhov sib txawv ntawm AUC thiab qhov siab tshaj yog qhov feem ntau vim yog qhov sib txawv ntawm lub cev qhov hnyav, tsis yog poj niam txiv neej, thiab tsis muaj ib qho tseem ceeb hauv kev kuaj mob.

Cov kev sib txawv tseem ceeb hauv cov chaw muag tshuaj ntawm moxifloxacin hauv cov neeg mob ntawm cov hnub nyoog sib txawv thiab zwm rau ntau pawg neeg tsis sib xws. Lub chaw muag tshuaj ntawm moxifloxacin hauv cov menyuam yaus tam sim no tsis to taub zoo.

Hauv cov neeg mob uas tseem niaj hnub siv ntshav tawm mus ntev rau cov neeg mob sab nraud los yog kev kuaj mob tsis tu ncua, nrog rau cov neeg mob uas lub raum tsis ua haujlwm (suav nrog cov neeg mob CC tsawg dua 30 ml / min / 1.73 m 2), kev hloov pauv tseem ceeb hauv pharmacokinetics ntawm moxifloxacin tsis tau kuaj pom. Cov teeb meem sib txawv ntawm lub siab ntawm moxifloxacin hauv cov neeg mob uas lub siab tsis ua hauj lwm (cov chav A thiab B raws li Child-Pugh nplai) piv nrog cov neeg mob lub siab ua haujlwm thiab cov neeg ua haujlwm noj qab haus huv zoo kuj tsis tuaj.

Kev ntsuas rau siv

Raws li cov lus qhia, Avelox 400 mg tau sau tseg rau:

Kab mob sib kis ntawm lub ntsws thiab ENT kabmob,
Kab mob rau hauv plab thiab urogenital,
Kev kis tus kab mob ntawm cov nqaij mos thiab tawv nqaij.

Avelox cov kev ua haujlwm tau pom tias muaj ntau yam ntawm cov kab mob gram-positive thiab gram-tsis zoo, cov kab mob tawm tsam beta-lactam thiab tshuaj tua kab mob macrolide, cov kab mob tiv thaiv acid thiab atypical cov qauv ntawm cov kab mob me me, nrog rau cov kab mob anaerobic uas tawm tsam kev noj tshuaj.

Cov Yuav Tsum Muaj

Cov lus qhia rau Avelox qhia tau tias nws qhov kev siv tsis tuaj yeem lees paub hauv cov kab mob xws li pseudomembranous colitis thiab mob raum tsis ua haujlwm. Nws yog txwv tsis pub noj tshuaj rau cev xeeb tub thiab lactating cov poj niam, cov menyuam yaus hnub nyoog qis dua 18 xyoo thiab cov neeg uas tsis nkag rau qee yam ntawm cov tshuaj. Kev xyuam xim tshwj xeeb yog qhov tsim nyog thaum muab tshuaj rau cov neeg mob uas muaj kab mob ntawm lub hauv nruab nrab lub paj hlwb, tawm tswv yim tias muaj feem ntau ntawm qhov mob nriaj leeg. Cov kab mob xws li daim siab tsis ua haujlwm, mob myocardial ischemia, bradycardia, hypokalemia kuj tseem yog lub laj thawj rau kev ceev faj hauv kev teem caij Aveloks.

Cov lus qhia rau kev siv Avelox: txoj kev thiab ntau npaum li cas

Aveloks tuaj yeem siv tau txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov. Cov ntsiav tshuaj tau nqos tag nrho, vim tias kev ncaj ncees ntawm lawv lub plhaub tsis tuaj yeem ua txhaum. Ib nrab-lub neej ntawm cov tshuaj yog cov txheej txheem ntev, yog li nws yog txaus los noj cov tshuaj ib zaug ib hnub.

Kev kho mob txhua hnub ntawm Avelox yog 400 mg. Tom qab lub qhov ncauj tswj hwm, cov tshuaj yuav nqus sai heev thiab yuav luag tag. Qhov siab tshaj plaws ntawm cov tshuaj nyob rau hauv cov ntshav tom qab siv ib zaug yog pom tom qab 0.5-4 teev txij li lub sijhawm saib xyuas. Kev ua tiav cov ntshav plasma moxifloxacin qib tshwm sim tom qab peb hnub ntawm kev siv li niaj zaus.

Txoj kev kho mob Infusion yog nqa tawm thaum pib kho nrog ib qho kev hloov pauv ntxiv ntawm tus neeg mob mus rau kev siv Avelox hauv ntsiav tshuaj, lossis siv tau kom txog thaum rov zoo.

Nyob ntawm tus kabmob, sijhawm ntev ntawm kev kho yog 7-10 hnub.

Sab sij huam

Cov kev tsis zoo tshwm sim tsis tshua muaj tshwm sim txaus, yuav raug rau txoj cai ntawm kev muab tshuaj. Avelox tuaj yeem ua rau cov kev tsis zoo hauv qab no:

Xeev siab, ntuav, mob plab, saj tsis meej, stomatitis, raws plab,
Ua kom lub plawv dhia, mob hauv siab, mob plab, nce ntshav siab,
Kiv taub hau, pw tsis tsaug zog, ntxhov siab, ntxhov siab, tsis meej pem, tsis muaj zog,
Mob nraub qaum, mob hauv cov leeg nqaij thiab pob qij txha, tendovaginitis, leeg caj dab,
Khaus, tawv nqaij ua pob,
Qog Ntshav, hyperlipidemia, hyperuricemia,
General malaise, o.

Noj ntau dhau

Nyob rau lub sijhawm tam sim no, nws tsuas muaj qee yam ntaub ntawv hais txog kev siv nyiaj ntau dhau ntawm Avelox. Nrog rau kev siv ib zaug hauv cov tshuaj hauv ib koob txog li 1200 mg lossis thaum nws noj hauv cov koob tshuaj tsis ntau tshaj 600 mg, tsis muaj kev phiv tshuaj rau 10 hnub.

Yog tias muaj kev noj ntau dhau, nws yuav tsum ua tib zoo kawm soj ntsuam daim duab ntawm tus neeg mob lub chaw thiab muab tshuaj kho cov tsos mob txhawb nrog kev saib xyuas nrog ECG.

Kev nqus ntawm cov roj carbon activated tam sim tom qab lub qhov ncauj tswj hwm ntawm moxifloxacin rau lub cev feem ntau pab kom tsis txhob muaj kev tiv thaiv kab mob ntau dhau rau kev siv yeeb tshuaj thaum noj ntau dhau.

Cov lus qhia tshwj xeeb

Yog tias muaj mob hauv cov pob qij txha lossis leeg pob txha thaum noj cov Avelox, cov tshuaj tau raug muab tso tseg kom tiv thaiv qhov tawv nqaij ntawm txoj leeg.

Hauv cov neeg mob qaug dab peg, Avelox yuav ua rau chua leeg.

Nrog rau kev nthuav dav ntawm kev mob plab zom mov loj thaum noj Avelox, nws raug tso tseg.

Kev nqus ntawm antacids thiab enterosorbents, nrog rau cov tshuaj uas suav nrog hlau, txhuas thiab magnesium yuav tsum tshwm sim nyob rau lub sijhawm sib txawv nrog Avelox, qhov sib txawv yuav tsum tsawg kawg yog 4 teev.

Avelox tsis raug siv los kho menyuam yaus.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Kev siv cov Avelox tuaj yeem ua rau muaj teeb meem hauv cov neeg mob thaum tsav tsheb thiab ua lwm yam muaj peev xwm ua haujlwm uas yuav tsum muaj kev xav ntau ntxiv thiab cuam tshuam tam sim ntawd lub hlwb, uas yog vim muaj kev phiv los ntawm cov tshuaj (qhov muag pom, qhov tsis zoo rau lub hauv nruab nrab lub paj hlwb).

Cev xeeb tub thiab lactation

Kev nyab xeeb ntawm kev tswj hwm ntawm moxifloxacin thaum cev xeeb tub tsis tau teeb tsa, yog li nws txoj kev siv yog contraindicated. Cov mob ntawm kev rov qab sib koom ua ke hauv cov menyuam yaus uas tau coj qee yam quinolones paub, tab sis cov nyhuv no tsis pom nyob rau hauv tus menyuam thaum lub sijhawm kho nrog cov pojniam xeeb tub los ntawm Avelox.

Cov kev tshawb fawb tsiaj tau pom zoo tias kev ua me nyuam muaj tshuaj lom ntawm moxifloxacin. Hais txog tib neeg, txoj kev pheej hmoo ntawm Avelox tseem tsis nkag siab zoo.

Moxifloxacin, zoo li lwm yam quinolones, ua rau lub pob txha mos ntawm cov pob qij txha loj hauv cov tsiaj uas yug ntxov. Kev tshawb nrhiav kab mob qhia tau tias moxifloxacin, nyob rau hauv qhov ntau ntau, kis mus rau hauv niam cov kua mis. Cov ntaub ntawv hais txog nws siv nyob rau hauv cov neeg mob thaum lactation tsis muaj, yog li ntawd, nws siv thaum lub sijhawm pub mis niam yog contraindicated.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Avelox coated ntsiav tshuaj:

1 ntsiav tshuaj muaj moxifloxacin (hauv daim ntawv ntawm hydrochloride) - 400 mg
hauv ib lub thawv 1 lub ntsej muag rau 5 lossis 7 pcs., lossis hauv ib lub thawv 2 hlwv rau 5 pcs.

Avelox infusion daws:

1 lub raj mis muaj moxifloxacin (hauv daim ntawv ntawm hydrochloride) - 400 mg
lwm cov khoom xyaw: sodium chloride, sodium hydroxide, hydrochloric acid, dej d / thiab.
250 ml -1 lub raj mis hauv ib lub thawv.

Avelox infusion daws:

1 pob ntawv muaj moxifloxacin (hauv daim ntawv ntawm hydrochloride) - 400 mg
lwm cov khoom xyaw: sodium chloride, sodium hydroxide, hydrochloric acid, dej d / thiab.
250 ml - lub hnab polyolefin (1) - hnab yas laminated nrog ntawv ci (12) hauv ib lub thawv.

Pharmacological kev txiav txim

Moxifloxacin yog cov tshuaj tua kab mob bactericidal nrog rau kev pom zoo ntawm kev ua ntawm fluoroquinolone series. Cov kab mob bactericidal ntawm cov tshuaj yog vim qhov inhibition ntawm cov kab mob topoisomerases II thiab IV, uas ua rau muaj kev ua txhaum ntawm biosynthesis ntawm DNA ntawm microbial cell thiab, yog li ntawd, ua rau kev tuag ntawm microbial cell. Tsawg kawg ntawm cov kab mob bactericidal ntau ntawm cov tshuaj feem ntau piv rau nws qhov tsawg kawg nkaus inhibitory ntau.

Cov kev ua uas ua rau muaj kev txhim kho kev tiv thaiv rau penicillins, cephalosporins, aminoglycosides, macrolides thiab tetracyclines tsis ua txhaum kev tua kabmob ntawm moxifloxacin.Tsis muaj ib qho kev rov qab tiv thaiv ntawm cov pab pawg ntawm cov tshuaj tua kab mob thiab moxifloxacin. Txog tam sim no, tseem muaj tsis muaj kev cuam tshuam ntawm plasmid tsis kam. Zuag qhia tag nrho cov kev txhim kho ntawm kev tiv thaiv yog qhov tsawg heev (10 7 - 10 10). Moxifloxacin tsis kam pib maj mam dhau los ntawm ntau yam kev hloov. Rov ua dua ntawm moxifloxacin rau cov kab mob me me hauv cov ntsiab lus hauv qab ntawm qhov tsawg tshaj plaws inhibitory concentration (MIC) yog nrog los ntawm qhov nce ntawm MIC. Cov xwm txheej ntawm cov ntoo khaub lig-tiv thaiv rau quinolones raug sau tseg. Txawm li cas los xij, qee cov kab mob gram-zoo thiab anaerobic cov kab mob tiv taus rau lwm cov quinolones tseem muaj lub siab moxifloxacin.

Hauv vitro moxifloxacin ua haujlwm tawm tsam ntau ntawm cov kab mob gram-negative thiab kab mob-gram zoo, anaerobes, cov kab mob tiv thaiv acid thiab atypical cov ntaub ntawv, xws li Mycoplasma, Chlamidia, Legionella, nrog rau cov kab mob tiv thaiv ß-lactam thiab mafolid tshuaj tua kab mob.

Dab tsi pab Avelox?

Cov cim tseem ceeb rau kev teem caij ntawm Avelox yog cov xwm txheej / kab mob:

Kab mob sib kis ntawm lub ntsws thiab ENT kabmob,
Kab mob rau hauv plab thiab urogenital,
Kev kis tus kab mob ntawm cov nqaij mos thiab tawv nqaij.

Cev xeeb tub

Kev nyab xeeb ntawm kev siv moxifloxacin thaum cev xeeb tub tsis tau tsim thiab nws txoj kev siv yog contraindicated. Cov mob ntawm kev rov qab sib koom ua ke hauv cov menyuam yaus uas tau txais qee cov quinolones tau piav qhia, txawm li cas los xij, qhov tshwm sim ntawm cov nyhuv no hauv menyuam hauv plab (thaum siv los ntawm leej niam thaum cev xeeb tub) tsis tau tshaj tawm.

Cov kev tshawb fawb tsiaj tau pom tias muaj tshuaj lom neeg muaj tsiaj txhu. Peb paub tsis meej tias yuav muaj xwm txheej dabtsi rau tib neeg.

Zoo li lwm yam quinolones, moxifloxacin ua rau cov pob txha mos ntawm cov pob qij txha loj hauv cov tsiaj ua ntej. Kev tshawb nrhiav kab mob tau pom tias ib qho me me ntawm moxifloxacin raug nteg tawm hauv niam cov kua mis. Cov ntaub ntawv hais txog nws siv nyob rau hauv cov poj niam thaum lactation tsis muaj. Yog li, kev teem caij moxifloxacin thaum pub mis niam yog contraindicated.

Yeeb tshuaj sib cuam tshuam

Nrog kev sib xyaw ntawm moxifloxacin nrog probenecid (qhov tsis muaj chaw kho mob tseem ceeb nrog cov nquag ntawm Avelox tau raug pov thawj), atenolol, morphine, ranitidine, digoxin, itraconazole, calcium uas muaj cov tshuaj ntxiv, glibenclamide, theophylline, qhov ncauj tiv thaiv, cyclosporine, tsis muaj kev xav tau.

Nrog rau kev siv ua ke ntawm Avelox thiab cov tshuaj uas cuam tshuam rau qhov txuas ntxiv ntawm QT luv, qhov cuam tshuam ntxiv ntawm lengthening QT luv tuaj yeem pom. Nrog moxifloxacin thiab cov tshuaj zoo sib xws, qhov kev pheej hmoo ntawm kev tsim ventricular arrhythmias, suav nrog polymorphic ventricular tachycardia (torsade de pointes), tau nce.

Tshuaj tswj hwm ntawm moxifloxacin thiab cov tshuaj hauv qab no uas cuam tshuam lub sijhawm ntev ntawm QT luv yog contraindicated:

tshuaj antihistamines (misolastine, astemizole, terfenadine),
chav kawm IA tshuaj tiv thaiv kab mob tsis haum (disopyramides, hydroquinidine, quinidine, thiab lwm yam),
chav kawm tshuaj tua kab mob III (ibutilide, amiodarone, dofetilide, sotalol, thiab lwm yam),
antimicrobials antimalarials, tshwj xeeb tshaj yog halofantrine, sparfloxacin, pentamidine, erythromycin (kev tswj hwm tshuaj),
tricyclic cov tshuaj tiv thaiv kab mob,
cov tshuaj tiv thaiv kab mob (suloprid, phenothiazine, haloperidol, sertindole, pimozide, thiab lwm yam),
lwm cov diphemanil, cisapride, bepridil, vincamine (kev tswj hwm dej num).

Kev tswj hwm tib lub sijhawm ntawm Avelox nrog multivit vitamins, minerals thiab antacids tuaj yeem ua rau qaug zog tsis tuaj yeem nqus moxifloxacin vim kev tsim cov chelate ntau nrog cov cations sib xyaw uas yog ib feem ntawm cov tshuaj no. Yog li ntawd, qib moxifloxacin hauv ntshav ntshav tuaj yeem qis dua qhov tsim nyog. Yog li, tshuaj tua kab mob (xws li didanosine) thiab tshuaj antacid npaj thiab lwm yam tshuaj uas suav nrog aluminium lossis magnesium, nrog rau cov tshuaj muaj zog ua kom sib luag thiab lwm yam tshuaj muaj zinc lossis hlau, pom zoo kom noj tsawg kawg 4 teev ua ntej lossis 4 teev tom qab qhov ncauj tswj hwm ntawm Avelox.

Nrog kev sib xyaw ntawm Avelox nrog warfarin, lub sijhawm prothrombin thiab lwm yam kev txwv ntawm cov ntshav coagulation tseem tsis hloov. Hauv cov neeg mob kho nrog cov tshuaj tiv thaiv anticoagulants ua ke nrog cov tshuaj tua kab mob, cov neeg mob ntawm cov tshuaj tiv thaiv anticoagulant ntau ntxiv tau pom.

Cov kev pheej hmoo muaj nrog rau cov xwm txheej dav dav thiab lub hnub nyoog ntawm tus neeg mob, nrog rau muaj tus kab mob sib kis nrog cov txheej txheem ua mob. Txawm hais tias qhov tseeb ntawm kev cuam tshuam ntawm moxifloxacin thiab warfarin tsis tau muaj pov thawj txog hnub tim, cov neeg mob uas tau txais kev kho mob ua ke nrog cov tshuaj no yuav tsum tau soj ntsuam INR tas li thiab, yog tias tsim nyog, nce lossis txo cov koob tshuaj tiv thaiv tsis tseem ceeb.

Digoxin thiab moxifloxacin kev xyaum tsis cuam tshuam rau qhov kev txwv pharmacokinetic ntawm lwm tus. Nrog kev qhia ntawm kev rov qab ua dua ntawm Avelox, qhov siab tshaj plaws ntawm digoxin tau nce txog 30%. Hauv qhov no, qhov tsawg kawg nkaus ntawm digoxin thiab tus nqi ntawm thaj chaw hauv qab qhov nkhaus pharmacokinetic "concentration - lub sijhawm" xyaum tsis hloov.

Nrog rau kev sib xyaw ua ke ntawm qhov ncauj ntawm moxifloxacin ntawm ib koob ntawm 400 mg thiab ua kom hluav ncaig hluav taws xob, qhov kev tiv thaiv kev noj qab haus huv ntawm Avelox txo qis dua ntau dua 80% vim qhov tsis muaj kev cuam tshuam ntawm nws qhov nqus. Yog hais tias haus dej ntau dhau, kev siv cov pa roj carbon activated thaum ntxov ntawm kev nqus yuav tiv thaiv tau qhov nce ntxiv ntawm cov kev raug mob hauv lub cev.

Cov tshuaj tawm ntawm Avelox hauv cov tshuaj nquag yog cov tshuaj hauv qab no: Vigamox, Moximac, Moxin, Moxifloxacin, Moxifloxacin hydrochloride, Plevilox. Tib pab pawg tshuaj xws li: Abactal, Basigen, Gatispan, Geoflox, Zanocin, Xenaquin, Levoflox, Normax, Ofloxacin, Ciprofloxacin thiab lwm yam.

Kev txheeb xyuas txog Aveloks

Kev txheeb xyuas txog Avelox sab laug los ntawm cov kws tshaj lij yeej muaj kev sib cav heev. Qee tus kws kho mob xav tias nws yog cov tshuaj tua kab mob uas muaj zog thiab zoo heev uas pab daws cov teeb meem kev ua txhaum ntawm tus kab mob xws li chlamydia, pyelonephritis, khaub thuas, SARS, thiab E. coli. Lwm tus kws tshaj lij hais tias muaj kev ua haujlwm tsis muaj txiaj ntsig zoo ntawm kev kho, tab sis lawv pom tias muaj ntau cov kev mob tshwm sim.

Cov neeg mob lub tswv yim hais txog Avelox kuj tseem sib xyaw. Coob tus neeg hais txog cov kev tsis zoo siab tshwm sim vim tias qhov ntawd yog qhov uas tsis qab los noj mov thiab xeev siab. Txawm li cas los xij, feem ntau cov neeg mob suav tias nws yog qhov tshuaj tiv thaiv zoo thiab ua tau zoo.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Avelox muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab ib qho kev daws teeb meem rau kev lis ntshav (tsis yog rau kev txhaj tshuaj). Ua kom koj paub koj tus kheej nrog tshuaj muaj pes tsawg leeg, piav qhia thiab piav qhia luv luv ntawm cov tshuaj:

Paj yeeb, matte, oblong, zaj duab xis-coated.

Transparent yellowish-greenish kua.

Qhov concentration ntawm moxifloxacin, mg

400 rau 1 lub raj mis

Titanium dioxide, microcrystalline cellulose, macrogol, croscarmellose sodium, oxide liab hlau, lactose monohydrate, hypromellose

Dej, sodium chloride, hydrochloric acid, tov kua sodium hydroxide.

Blisters rau 5 lossis 7 pcs., Pob 1 lossis 2 blisters.

250 ml vials lossis ntim.

Tsuas tshuaj thiab tswj hwm

Cov kws kho mob feem ntau sau ntawv rau Avelox rau mob angina, mob qog ntshav, mob ntsws, vim muaj cov nyhuv antibacterial, cov tshuaj tua cov kab mob ua rau tus kab mob ua rau kis mob thiab txo tus mob. Cov txheej txheem ntawm kev thov, kev noj tshuaj ntau dua thiab lub sijhawm ntawm cov chav kho yog nyob ntawm hom, qhov mob ntawm cov kabmob thiab daim ntawv ntawm cov tshuaj. Cov ntsiav tshuaj noj ntawm qhov ncauj, qhov kev hais daws yog parenteral, nyob rau hauv daim ntawv ntawm infusions.

Avelox hauv cov ntsiav tshuaj noj ntawm qhov ncauj ntawm 400 mg 1 lub sijhawm / hnub. Cov ntsiav tshuaj tsis yog zom, ntxuav nrog kua, tsis hais tus noj mov. Hauv lub sijhawm laus, qhov tshuaj tsis hloov. Lub sijhawm kho yog nyob ntawm tus kabmob:

Lub chav kawm ntawm kev kho mob nyob rau hauv hnub

Exacerbation ntawm mob ntsws ntev

Kev mob ntsws hauv zej zog tom qab kawm tag ntawm Avelox infusions

Txoj kev lis ntshav daws

Rau kev siv dej, cov tshuaj ntawm tib lub npe hauv koob tshuaj 400 mg ib zaug / hnub yog npaj siab. Kev siv tshuaj kho mob ntev txog 21 hnub. Nrog rau kev mob ntsws hauv zej zog, kev kho mob ntev li 7-14 hnub, nrog rau mob hnyav - 7-21 hnub, nrog mob plab - mob plab - 5-14 hnub. Rau cov neeg laus thiab cov neeg mob uas lub siab tsis ua hauj lwm, qhov ntau npaum hloov tsis hloov.

Kev daws yog muab tshuaj rau ntawm ib teev. Cov tshuaj yeeb yaj kiab tuaj yeem siv nrog kev zom nrog dej, Lub suab lub zog, sodium chloride, dextrose lossis xylitol. Tsuas yog ib qho kev daws teeb meem yooj yim tshaj tawm kev paub tsis muaj kev ua kom muaj kiv, muaj kev poob mus. Tom qab kev daws teeb meem nrog cov kuab tshuaj, cov tshuaj yuav ruaj khov thawm hnub, muab cia nws khaws cia hauv chav tsev kub.

Thaum cev xeeb tub

Kev nyab xeeb ntawm kev siv moxifloxacin thaum cev xeeb tub tsis tau tsim, vim li ntawd nws txoj kev siv yog contraindicated. Kev tshawb fawb ntawm cov nas pom tias kev ua me nyuam muaj mob toxicity. Hauv cov tsiaj txhu, Moxifloxacin ua rau muaj kev puas tsuaj rau pob txha mos ntawm cov pob qij txha loj, tawm hauv cov niam mis, yog li kev kho mob rau kev pub niam mis yog contraindicated.

Hauv thaum yau

Avelox tuaj yeem siv tsis tau rau thaum yau thiab hluas thaum muaj 18 xyoo. Qhov no yog txuam nrog kev pheej hmoo siab ntxiv ntawm txoj kev ua haujlwm tsis zoo ntawm cov pob qij txha thiab pob txha mos. Ntau dhau heev nrog rau cov tshuaj tua kab mob tuaj yeem ua rau lom, txhim kho pob khaus pob, ua rau lub zog thiab poob siab ntawm cov hlab ntsha nruab nrab. Qhov no yog qhov txaus ntshai tshwj xeeb thaum me thiab ntawm cov menyuam kawm ntawv.

Avelox thiab cawv

Txhawm rau zam kev pheej hmoo ntawm lub siab ua haujlwm tsis txaus siab, rau lub sijhawm ntawm Avelox txoj kev kho, koj yuav tsum tsis kam lees haus cawv haus dej haus cawv lossis tshuaj muaj yees. Cawv siv dej cawv cuam tshuam rau cov plab hnyuv siab raum, ua rau muaj kev haus ib ce ntau thiab mob nyhav. Ethanol txo qis kev ua haujlwm ntawm cov tshuaj, uas ua rau muaj kev phiv tshuaj tsis zoo. Koj tuaj yeem rov qab noj nws ib hlis tom qab kawg ntawm kev kho mob.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Avelox yog muag los ntawm daim ntawv sau yuav tshuaj, khaws cia hauv qhov kub txog 25 degrees rau ntsiav tshuaj thiab 15-30 degrees rau kev daws teeb meem. Lub txee lub neej ntawm cov ntsiav tshuaj thiab vials ntawm kev daws yog tsib xyoos, kev hais haum hauv cov ntim yog peb xyoos.

Generics nrog tib yam tshuaj muaj zog thiab hloov nrog lwm qhov sib txuam, tab sis nrog tib cov txiaj ntsig ntawm tib neeg, raug xa mus rau Aveloks analogues. Tshuaj tua kab mob analogues:

Aquamox - kev daws raws moxifloxacin,
Moxifluor yog cov tshuaj tseem ceeb hauv cov lus nug,
Megaflox - ntsiav tshuaj nrog tib yam sib xyaw ua ke,
Hainemoks - kev npaj ntsiav tshuaj, khoom noj khoom siv analogue,
Moxifloxacin yog cov tshuaj hloov tshuaj tshaj plaws.

Cov lus qhia rau siv (Txujci thiab ntau npaum li cas)

Cov ntsiav tshuaj tau noj yam tsis muaj kev zom lossis tsis faib, tsis hais noj mov.

Raws li cov lus qhia rau Avelox 400 mg, rau cov neeg laus, kev noj tshuaj txhua hnub yog ib ntsiav tshuaj lossis 400 mg tshuaj tua kab mob.

Lub sijhawm thiab hom kev tswj hwm yuav tsum yog txiav txim los ntawm tus kws kho mob uas koom nrog, nyob ntawm qhov mob hnyav, nws txoj kev ua tau zoo thiab kev rhiab ntawm tus neeg mob.

Raws li txoj cai, thaum pib kho, ib qho tshuaj tawm hauv kev txhaj tshuaj, tom qab ntawd, tom qab qhov pib ntawm kev txhim kho, ntsiav tshuaj tuaj yeem kho tau.

Nrog exacerbation mob ntevmob ntsws lub chav kawm ntawm kev kho mob nrog tshuaj yog 5 hnub. Ntawm mob ntsws - txij 7 (txhaj tshuaj) txog 10 hnub.

Ntawm mob sinusitis thiab kev sib kis tsis zoo ntawm cov tawv nqaij thiab cov nqaij mos, lub sijhawm siv tshuaj tua kab mob yog ib lub lis piam.

Nrog kev mob hnyav ntawm lub plab hu ua pelvic plab hnyuv siab raum, chav kho mob yog ob lub lis piam.

Yog tias muaj kev sib txuam ntawm cov tawv nqaij thiab cov qauv hauv qab ntawm daim tawv nqaij, txoj kev kho yog nqa tawm stepwise thiab kav los ntawm 5 hnub txog ob lub lis piam.

Hauv cov neeg uas tsis muaj mob raum thiab mob siab, cov neeg laus, thiab rau cov pab pawg neeg sib txawv, kev kho kom haum yuav tsis ua.

Cov lus qhia rau kev siv Avelox rau kev txhaj tshuaj

Siv tsuas yog cov tshuaj ntshiab, tsis muaj nag lossis daus ntawm huab.

Cov tshuaj tau muab txhaj tshuaj kom ntev, rau 60 feeb, tsawg kawg yam tsis muaj kev ceev faj. Tsis tas li feem ntau cov tshuaj tua kab mob sib xyaw nrog T adapter nrog dej rau kev txhaj tshuaj sodium tshuaj dawb(0.9% lossis 1M), kev daws teeb meem dextrose (5%, 10%, 40%), kev daws xylitol 20%, lub nplhaib kev daws teeb meemCov. Qhov npaj ua tau zoo tuaj yeem khaws cia hauv chav tsev li 24 teev.

Hauv tib lub koob txhaj tshuaj lossis poob ntsej muag, lwm tus neeg sawv cev tsis sib xyaw.

Kev sib txuam

Txhais tau tias zoo nrog atenolol, theophylline, calcium npaj, ranitidine, tshuaj tiv thaiv qhov ncauj, tshuaj intraconazole, morphine, glibenclamide, digoxin, warfarin, probenecid.

Txawm li cas los xij, thaum ua ke nrog cov tshuaj tiv thaiv tsis tau ntiag tug yuav tsum tau txiav txim siab thiab tsis tu ncua INRkho qhov tshuaj noj ntawm lub tshuaj kom yog.

Thaum muab sib xyaw nrog antacids, multivitamins thiab cov zaub mov tau tsim chelated complexes nrog polyvalent cations, cov concentration ntawm cov tshuaj tua kab mob hauv cov ntshav txo qis. Hauv qhov no, nruab nrab ntawm 4 teev nruab nrab ntawm kev noj cov tshuaj yuav tsum tau soj ntsuam.

Yog tias koj sib xyaw nrog tshuaj nrog cov pa roj carbon lossis lwm yam enterosorbents, tom qab ntawd lub bioavailability ntawm cov tshuaj yog zoo txo (kwv yees 80%). Nrog kev tswj hwm intravenous, daim duab no nce mus txog 20%.

Kev daws rau Txoj kev lis ntshav yuav tsum tsis txhob siv nrog 10% thiab 20% sodium chloride, sodium hydrogencarbonate 4.2% thiab 8.4%.

Cov Lus Qhia ntawm Aveloks

Tus analogues ze tshaj plaws ntawm Avelox: Moxifloxacin-Farmex, Moxifloxacin, Moxifluor, Moflox, Moxifloxacin-Credofarm, Maxicin, Moxifluor 400, Moxin, Tevalox, Mofloxin Lupine.