Cov tshuaj Akkuzid: cov lus qhia rau kev siv

Cov tshuaj sib xyaw nrog cov nyhuv antihypertensive, uas suav nrog ob qho tshuaj nquag: quinapril (inhibitor ACE) thiab hydrochlorothiazide (diuretic) hauv peb ntau qhov kev sib txuas ua ke.

Hinapril Synthesis catalyst angiotensin IIuas yog vim muaj kev txhawb nqa ntawm adrenal cortex (ntau lawm aldosterone), cuam tshuam vascular laus thiab muaj cov nyhuv vasoconstrictor. Hinapril inhibits ACE (cov ntaub so ntswg thiab ncig mus ncig) thiab txo cov vasopressor kev ua si thiab kev pom zoo aldosteroneCov. Nres qhov kev cuam tshuam tsis zoo angiotensin II los tsim reninua rau muaj kev ua ub no ntau ntxiv renin.

Poob qis HUAB TAIS tshwm sim tiv thaiv keeb kwm ntawm qhov txo qis hauv lub raum tsis kam thiab OPSStib lub sijhawm, kev hloov pauv ntawm cov txiaj ntsig hauv lub plawv, Lub plawv dhia, glomerular pom thiab lub raum ntshav feem ntau yog qhov tsis lees paub lossis txawm tias qhaj. Hinapril me ntsis txo cov poov tshuaj plam los ntawm kev nqis tes ua hydrochlorothiazideuas, muaj cov nyhuv diuretic, ua rau muaj ntshav txaus kev ua haujlwm, ua rau kev zais cia aldosterone, nce potassium cov ntsiab lus hauv cov ntshav thiab nce ntxiv nws cov kev nthuav tawm los ntawm ob lub raum. Cov nyhuv antihypertensive tshwm sim hauv ib teev thiab nce mus txog qhov siab kawg tom qab 3 teev, txuas ntxiv thoob plaws ib hnub.

Hydrochlorothiazide - hais txog cov pab pawg ntawm diuretics, cuam tshuam rau kev ua haujlwm ntawm lub raum, txhim kho kev tsis tuaj yeem ntawm sodium, potassium, chlorides, bicarbonate ions thiab dej thaum txo cov calcium uas tsis ua kom haum. Lub diuretic nyhuv yog manifested tom qab 2 teev, cov nyhuv siab tshaj plaws yog tom qab 4 teev thiab nws lub sijhawm yog 6-12 teev.

Kev sib xyaw ua ke ntawm cov tshuaj nquag (quinapril thiab hydrochlorothiazide) muab qhov kws nqig zuj zug HUAB TAIStshaj li qhov kev txiav txim ntawm txhua tus ntawm lawv tus kheej.

Cov Tshuaj Pharmacokinetics

Ob qhov tshuaj yeeb tshuaj tsis cuam tshuam rau ib leeg.

Hinapril - Cmax mus txog tom qab 2 teev. Kev kawm ntawv ntawm kev nqus yog li 60%. Siab khi rau cov ntshav protein. Hauv lub siab, biotransformed rau quinaprilataua ib qho muaj zog inhibitor ACECov. Tsis nkag mus BBBCov. Nws yog tsuas yog tawm ntawm lub raum, T1 / 2 - txog 3 teev.

Hydrochlorothiazide - muaj kev nqus qis dua, qhov degree ntawm nqus ntawm 50-80%. Cmax tau mus txog hauv 1-3 teev. Tsis nkag mus BBBCov. Lub cev tsis tiv thaiv kab mob, tshem tawm tsis hloov pauv ntawm lub raum. T1 / 2 - txij 4 txog 15 teev.

Cov Yuav Tsum Muaj

• Siab rhiab heev rau cov tshuaj,
• nyob rau hauv lub anamnesis - angioedema tom qab kho nrog inhibitors ACE,
• Addison's disease,
• anusia,
• hnub nyoog txog 18 xyoo
• mob ntshav qab zib mellitus,
• cev xeeb tub thiab lactation.
• cov lus hais lub raumdaim siab ua hauj lwm
• xam phaj lactases.

Akkuzid, cov lus qhia rau siv (qauv thiab ntau npaum li cas)

Akkuzit ntsiav tshuaj noj 1 zaug hauv ib hnub yam tsis tau hais txog kev noj zaub mov. Qhov pom zoo kom tau txhaj thawj hnub rau cov neeg mob uas tsis tau txais lub tshuaj diuretic yog 10 mg + 12.5 mg (ib ntsiav tshuaj ntawm Accuzit 10), yog tias tsim nyog, thawj koob tshuaj txhua hnub tau nce mus rau qhov siab tshaj plaws txhua hnub koob tshuaj 20 mg + 25 mg (ib ntsiav tshuaj ntawm Accuzit 20). Raws li txoj cai, cov nyhuv tshwm sim thaum noj cov tshuaj hauv ntau npaum li ntawm (10 +12.5 txog 20 +12.5) mg ib hnub. Cov neeg laus yog cov tsis xav tau kev hloov kho koob. Nyob rau hauv qhov muaj kev mob raum loj hauv cov neeg mob, cov tshuaj yuav tsum tsis txhob siv los ua kev kho thaum xub thawj.

Noj ntau dhau

Cov kev tshwm sim tseem ceeb ntawm kev siv ntau tshaj nrog kev siv lub sijhawm ntev ntawm kev siv tshuaj nyob rau hauv ntau dua kev kho mob yog ib qho pheej ploj zuj zus HUAB TAIS, kev ntxhov siab hauv dej thiab electrolytic tshuav nyiaj, qhia tshuaj tiv thaiv hypochloremia, tshuaj mob siab ntsws, hypokalemia.

Kev sib txuam

Nrog rau kev tswj hwm thooj txhij ntawm Accuzide nrog tshuaj tua kab mob ntawm cov pab pawg tetracycline kev nqus txheej txheem tetracycline txo los ntawm ib feem peb. Nws tsis pom zoo kom sau tshuaj lithium npaj ua ke nrog diuretics, txij li diuretics txo qis lub raum kev ua kom huv ntawm lithium thiab kev pheej hmoo ntawm intoxication nce ntau. Thaum Noj Nrog Accid ethanolopioid analgesics, barbiturates thiab Tshuaj c rau kev tso tshuaj kom tsaug zog txoj kev pheej hmoo ntawm kev tsim orthostatic hypotensionCov. Nrog tib lub sijhawm tswj hwm ntawm Accuzide nrog tshuaj insulin lossis cov tshuaj hypoglycemic ib qho kev hloov kho ntawm cov tshuaj hypoglycemic yog qhov tsim nyog. Hydrochlorothiazide ua ib feem ntawm Akkuzid txhim kho qhov kev txiav txim ntawm antihypertensive tshuaj noj ib txhij nrog nws.

Nrog tib lub sijhawm tswj hwm ntawm cov tshuaj corticosteroid nrog Accuid, qhov nce ntawm cov poov tshuaj thiab lwm yam tshuaj electrolytes yuav ua tau. Txais tos NSAIDs ua rau kev ua kom tsis muaj zog ntawm cov tshuaj tiv thaiv ntshav, tshuaj tiv thaiv kab mob thiab natriuretic ua kom tsis muaj zog. Nrog tib lub sijhawm tswj hwm kev ua haujlwm ntawm cov leeg ua ke nrog Akkuzid, lawv qhov kev ua tau zoo tuaj.

Tsuas tshuaj thiab tswj hwm

Kev noj tshuaj Accuid li ib txwm yog ib ntsiav tshuaj (10 mg / 12.5 mg) ib hnub twg txhua hnub. Koj tus kws kho mob yuav nce qhov ntau ntxiv rau ob ntsiav tshuaj hauv ib hnub, uas tuaj yeem noj ua ke ib hnub lossis cais ib zaug - ib ntsiav tshuaj thaum sawv ntxov, noj ib hmos.

Yuav tsum haus kom raug Accuzide raws li koj tus kws kho mob tau qhia. Tsis txhob noj tshuaj ntau dua li koj tus kws kho mob pom zoo.

Sim noj tshuaj rau tib lub sijhawm ntawm ib hnub ntawm txhua hnub, tsis hais noj mov dabtsi.

• Yog tias koj tsis nco qab noj tshuaj ntau dua, noj tam sim ntawd, uas koj nco qab, tsis tas tos rau lwm zaus koj noj cov tshuaj no. Tsis txhob haus ob lub tshuaj.
• Yog tias koj siv cov tshuaj Akkuzid yuam kev ntau dhau lawm, qhia rau koj tus kws kho mob tam sim ntawd Yog tias koj tsis tuaj yeem ua li no, hu rau chav tuam tsev kho mob ze tshaj plaws. Noj raws li ntim ntawm cov tshuaj, txawm hais tias tsis muaj cov tshuaj seem kom cov neeg ua haujlwm hauv tsev kho mob yooj yim los xyuas seb qhov tshuaj twg koj tau siv.
• Kev siv nyiaj yuav tsis raug pom zoo rau menyuam yaus. Cov tshuaj tsis tau kawm hauv cov neeg mob hnub nyoog qis dua 18 xyoo.

Sab sij huam

Ib yam li lwm yam tshuaj siv rau koj tus mob, qee zaum Accuzide tuaj yeem muaj qhov tsis xav zoo (phiv). Yog tias koj muaj cov tsos mob no, koj yuav tsum sab laj nrog koj tus kws kho mob.

• Pheej hnoos qhuav.
• Xeev siab, ntuav, raws plab, cem quav, kem plab, plab zom mov, mob plab, lossis mob plab.
• Mob taub hau, kiv taub hau, yaug, pw tsaug zog, tsaug zog, nkees, tsis nco qab lossis nkees, lossis ib txwm muaj kev qaug zog.
• Mob mob nraub qaum, hauv siab, cov leeg, lossis pob qij txha (gout).
• Cov tawv nqaij ua pob xoo, khaus lossis ua kom lub ntsej muag ua rau lub teeb, ua xua tawv nqaij ua pob.
• Kab mob hauv lub raum (los ntawm lub sijhawm, yog tias koj tus kws kho mob xav tias kev loj hlob ntawm lub raum, koj tus kws kho mob yuav sau ntawv kuaj zis)

Cov kev mob tshwm sim tsis tshua muaj tshwm sim muaj xws li: kev tawm hws ntau dhau, qhov ncauj qhuav / qa, plaub hau poob, impotence, mob txeeb zig , tsis meej pem, tsis txaus siab, tinnitus, plooj tsis pom kev, tsis hnov ​​qab saj, edema (peripheral).

Yog tias koj muaj cov tsos mob no, koj yuav tsum sab laj nrog koj tus kws kho mob.

Yog tias koj tau tsim qhov mob ntawm kiv taub hau, tom qab ntawd koj yuav tsum caiv tsis txhob tsav tsheb thiab lwm yam txheej txheem.

Kev tso cai tuaj yeem ua rau qee qhov hloov pauv hauv cov ntshav cov duab. Yog li, koj tus neeg saib xyuas kev noj qab haus huv yuav muab tshuaj tawm ntshav los kuaj xyuas qhov no. Yog tias koj muaj doog ntshav, qhov kev xav tias lub cev rog dhau los, yog tias koj muaj ntshav qab zib thiab koj pom tias muaj ntshav qabzib ntau ntxiv, qhia rau koj tus kws kho mob thiab yog tias tsim nyog, koj yuav tau kuaj ntshav.

Cov kev mob tshwm sim no muaj tsawg heev, tab sis mob hnyav, yog li yog tias koj muaj, qhia rau koj tus kws kho mob tam sim ntawd.

• Angioneurotic edema (o ntawm lub ntsej muag, tus nplaig, trachea - tuaj yeem ua rau muaj kev nyuaj rau kev ua pa). Nyob rau tib lub sijhawm, angioneurotic edema ntawm lub plab thiab cov hnyuv (mob hnyuv angioedema - mob hnyuv pob txha) yuav muaj kev ywj pheej. Hauv qhov no, koj yuav hnov ​​zoo, tsis ntuav thiab mob plab yuav tshwm sim. Cov no muaj tsawg, tab sis muaj kev txhaum fab hnyav heev, thiab yog tias koj tau tsim lawv, koj yuav tsum hu rau lub tsheb thauj neeg mob tam sim ntawd.
• Zaws hauv siab, hauv siab, hnov ​​mob hauv siab, tsis hnov ​​suab lossis ua tsis taus pa.
• Mob caj pas lossis mob ua paug hauv qhov ncauj. Yog tias koj muaj teeb meem lub raum lossis koj muaj qhov mob sib txawv ntawm cov nqaij mos, koj tuaj yeem txhim kho neutropenia / agranulocytosis (cov qe ntshav dawb tsis txaus), uas tuaj yeem ua rau kis mob, mob qa, lossis kub cev. Yog tias koj muaj cov mob sib txawv ntawm cov nqaij mos sib kis, koj tus kws kho mob yuav sau ntawv tuaj kuaj ntshav rau koj kom saib xyuas tus mob no.
• Kev tsaus muag, tshwj xeeb tshaj yog thaum sawv ntsug, yuav txhais tau tias koj cov ntshav siab qis heev. Qhov xwm txheej no feem ntau yuav tshwm sim thaum koj noj tshuaj diuretics (diuretics), lwm yam tshuaj uas txo cov ntshav siab, thiab haus dej cawv yog tias koj lub cev qhuav dhau lossis nyob ntawm hemodialysis thaum koj noj nws ua ke nrog Accuzide. Yog tias koj lub qhov muag tsaus zuj zus lossis hnov ​​zoo li koj tab tom dhau mus, coj txoj hauj lwm tav toj thiab pw rau ntawd kom txog thaum lub siab xav dhau.
• Lwm qhov kev tshwm sim uas tsis tshua pom tab sis muaj cov kev mob tshwm sim xws li ua rau daj ntseg ntawm qhov muag thiab tawv nqaij (nqaij daj), mob hnyav ntawm lub plab thiab sab nraub qaum (mob caj dab), ua kom tsis muaj zog nyob rau sab sauv thiab qis dua, lossis nyuaj rau kev hais lus (tej zaum mob stroke).

Cev xeeb tub

Kev siv yeeb tshuaj Meej contraindicated thaum cev xeeb tub, cov poj niam npaj lub cev xeeb tub, nrog rau cov poj niam uas muaj hnub nyoog yug me nyuam uas tsis siv txoj hauv kev muaj txiaj ntsig kom muaj txiaj ntsig.
Cov poj niam ntawm kev muaj me nyuam hnub nyoog uas tau noj cov tshuaj Accuside® yuav tsum siv txoj hauv kev ua kom muaj txiaj ntsig zoo.
Yog tias cev xeeb tub tshwm sim thaum kho nrog Accuzide, cov tshuaj yuav tsum tsis ua ntxiv kom sai li sai tau.
Kev teem sijhawm ntawm ACE inhibitors thaum cev xeeb tub yog los ntawm kev pheej hmoo ntawm kev txhim kho lub cev tsis zoo ntawm lub plawv thiab lub paj hlwb ntawm cov menyuam hauv plab. Ntxiv rau, tiv thaiv keeb kwm yav dhau los ntawm kev siv ACE inhibitors thaum cev xeeb tub, cov neeg mob oligohydramnios, kev yug ntxov, yug ntawm cov menyuam muaj lub plawv dhia tsis ua haujlwm, tsis ua haujlwm rau lub raum, nrog rau kev mob hlwb tsis ua haujlwm, kev mob hlwb ntawm cov pob txha pob txha taub hau, kev cog lus ntawm cov leeg, craniofacial anomalies, pulmonary hypoplasia. , qhib ductus arteriosus, zoo li muaj mob ntawm cov me nyuam hauv plab thiab cov me nyuam mos tuag. Feem ntau, oligohydramnios yog kuaj tau tom qab tus me nyuam hauv plab tau ua tsis tau.
Cov menyuam yug tshiab uas muaj kev nkag kis mob rau ACE inhibitors yuav tsum raug kuaj xyuas txhawm rau txhawm rau txhawm rau soj ntsuam cov leeg ntshav hypotension, oliguria thiab hyperkalemia. Thaum oliguria zoo nkaus li, ntshav siab thiab lub raum ntshav zoo yuav tsum tswj hwm.
Thiazides hla lub cev placental thiab pom nyob hauv cov ntshav ntawm txoj hlab ntaws. Cov teebmeem tsis muaj teratogenic ntawm thiazides suav nrog kev daj ntseg thiab thrombocytopenia ntawm tus menyuam thiab / lossis tus menyuam tshiab, thiab tseem muaj lwm qhov xwm txheej tsis zoo tshwm sim hauv cov neeg laus kuj raug tso cai.
ACE cov tshuaj tiv thaiv kab mob, suav nrog hinapril, ua kom tsawg mus rau hauv niam cov kua mis. Thiazide diuretics raug tawm hauv cov kua mis. Raws li qhov ua tau los ntawm qhov tsim muaj cov kev tsis haum siab hauv cov menyuam mos, Yug kom tsis txhob siv rau thaum lub sijhawm lactation, thiab yog tias tsim nyog, kev pub mis niam yuav tsum tau tsum.

Daim ntawv tso tawm

tab. zaj duab xis txheej, 10 mg + 12.5 mg: 30 pcs.
tab. zaj duab xis txheej, 20 mg + 12.5 mg: 30 pcs.
tab. zaj duab xis txheej, 20 mg + 25 mg: 30 pcs.

1 ntsiav tshuajMeej muaj: quinapril hydrochloride 10.832 mg, uas sib haum rau cov ntsiab lus ntawm quinapril 10 mg
hydrochlorothiazide 12,5 mg.
Cov neeg siv: lactose monohydrate - 32.348 mg, magnesium carbonate - 35.32 mg, povidone K25 - 4 mg, crospovidone - 4 mg, magnesium stearate - 1 mg.
Cov lus sib xyaw ntawm cov zaj duab xis txheej: opadray paj yeeb OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, hlau oxide zas xim daj, hlau zas xim oxide liab) - 3 mg, tshuaj ntsuab ciab - 0.05 mg.
1 ntsiav tshuaj Akkuzid muaj: quinapril hydrochloride 21.664 mg, uas sib haum rau cov ntsiab lus ntawm quinapril 20 mg.
hydrochlorothiazide 12,5 mg.
Cov neeg siv: lactose monohydrate - 77.196 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Cov lus sib xyaw ntawm cov zaj duab xis txheej: opadray paj yeeb OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, hlau oxide zas xim daj, hlau zas xim oxide liab) - 6 mg, tshuaj ntsuab ciab - 0.1 mg.
1 ntsiav tshuajMeej muaj: quinapril hydrochloride 21.664 mg, uas sib haum rau cov ntsiab lus ntawm quinapril 20 mg.
hydrochlorothiazide 25 mg
Cov neeg siv: lactose monohydrate - 64.696 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Cov lus sib xyaw ntawm cov zaj duab xis txheej: opadray paj yeeb OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, hlau oxide zas xim daj, hlau zas xim oxide liab) - 6 mg, tshuaj ntsuab ciab - 0.1 mg.

Tsuas tshuaj thiab tswj hwm

Akkuzid yog npaj rau kev siv qhov ncauj. Kev ntau ntau ntawm kev txais - 1 zaug nyob rau ib hnub, tsis hais txog ntawm kev ua zaub mov.

Cov neeg mob uas tsis kho cov tshuaj diuretic yog qhov sau ncaj qha 12.5 mg + 10 mg ntsiav tshuaj, 1 pc txhua. ib hnub. Yog tias tsim nyog, nws muaj peev xwm muab tshuaj rau Kev Nqis 25 mg + 20 mg, 1 pc. ib hnub.

Kev tswj ntshav siab tau feem ntau yog ua tiav los ntawm kev siv txhua hnub ntawm cov tshuaj hauv thaj tsam ntawm 12.5 mg + 10 mg txog 12.5 mg + 20 mg.

Kev noj tshuaj ntxiv rau cov pab tshwj xeeb ntawm cov neeg mob:

• lub raum tsis ua haujlwm ntawm qhov mob me (ua kom tsis pom kev zoo tsawg dua 60 ml / min): Kev kho 12,5 mg + 10 mg - 1 pc. ib hnub
• lub raum tsis ua haujlwm ntawm qhov mob hnyav (qhov kev tshem tawm ntawm tus neeg lub cev 60-30 ml / min.): thawj zaug ntawm quinapril yog 5 mg nrog ntxiv rau kev ua kom dhau, cov neeg mob ntawm cov pab pawg no tsis tau kho kom zoo raws li kev kho thaum xub thawj,
• lub hnub nyoog dhau los: Kev nce qib 12.5 mg + 10 mg - 1 pc. ib hnub, tsis tas yuav hloov qhov tshuaj.

Sab sij huam

Cov xwm txheej tsis zoo uas tau tshwm sim hauv ntau dua 1% ntawm cov neeg mob tau txais quinapril nrog hydrochlorothiazide:

• kuaj ntsuas: hypercreatininemia, hyperazotemia,
• lwm yam: mob taub hau, kiv taub hau, xeev siab, ntuav, mob plab zom mov, mob plab, mob hauv siab, mob plab, mob nraub qaum, mob voos, mob ntsws, mob ntsws, mob ntsws, mob ntsws, mob txhaws, ua pa nyuaj. cov tsos mob ntawm vasodilation, nkees, asthenic syndrome, insomnia.

Cov xwm txheej tsis zoo uas tau tshwm sim hauv 0.5-1% ntawm cov neeg mob tau txais quinapril nrog hydrochlorothiazide:

• hematopoietic system: txo qis hauv qib ntawm leukocytes, platelets, granulocytes, hemolytic anemia,
• cov leeg hlab ntsha: kev nyuaj siab, nkees nkees, nce ntxiv kev txob taus, zoo nkaus li loog loog thiab mob ntawm cov nqaj,
• kev mob plawv rau lub plawv: txhaws ntswg, tachycardia, arrhythmia, angina pectoris, lub plawv tsis ua hauj lwm, myocardial infarction, ntau dhau los txo cov ntshav siab, orthostatic hypotension, tsaus muag, ischemic mob stroke, tawg tawg, peripheral edema,
• cov kab mob ua pa: sinusitis, txog siav,
• lub plab zom mov: tso quav tsis txaus, pom lub plab, ua pa ntawm lub qhov ncauj thiab lub qa, angioedema, mob plab hnyuv hauv lub cev, kab mob rau lub cev, tus kabmob ua paug, mob siab rau daim siab tsis ua haujlwm, kuaj ntshav los ntawm txoj hnyuv,
• kev ua xua: tawv nqaij ua pob khaus, urticaria, mob pruritus, Quincke's edema, tshuaj tiv thaiv kab mob, Stevens-Johnson syndrome, ua kom mob dermatitis, pemphigus, phiv tshuaj tsis zoo, tawm hws ntau dhau,
• musculoskeletal system thiab cov ntaub so ntswg mob: mob pob txaws,
• genitourinary system: mob txeeb zig, mob raum tsis ua haujlwm, mob raum tsis ua haujlwm, inhibition ntawm potency,
• yam khoom hauv lub zeem muag: qhov tsis pom kev,
• lwm cov kev cuam tshuam: hyperkalemia, alopecia, hauv kev sib xyaw nrog kub npaj: xeev siab, ntuav, ntsej muag hyperemia, qhov cim tseg rau cov ntshav siab, cov mob khaub thuas zoo li syndrome.

Cov tsos mob hauv qab no yog cov yam ntxwv ntawm kev haus dej ntau dhau ntawm Akkuzid: kev cuam tshuam hauv cov dej-ntsev cov metabolism hauv lub cev, ntau cov ntshav tawm ntawm cov ntshav siab, txo qis hauv bcc tiv thaiv keeb kwm ntawm yuam diuresis. Ua ke nrog kev mob plawv glycosides, qhov ntxim nyiam ntawm kev loj hlob arrhythmias nce.

Kev kho ntau tshaj: kev txiav tsis siv tshuaj, kev kho mob plab zom mov, kev tswj hwm qhov ncauj ntawm adsorbents, kev tso ntshav (iv) kev tswj hwm ntawm 0.9% sodium chloride daws, kev pab txhawb nqa thiab cov qauv kho mob.

Cov lus qhia tshwj xeeb

Muaj cov ntaub ntawv pov thawj ntawm cov mob ntawm angioedema ntawm caj dab thiab ntsej muag thaum kho mob nrog ACE inhibitors, suav nrog hauv 0.1% ntawm cov neeg mob tau txais hinapril. Nyob rau hauv cov ntaub ntawv ntawm angioedema ntawm lub ntsej muag, tus nplaig, lub suab nrov nrov dhau los, lub qhov muag lossis lub laryngeal xuav thiab ua pa nyuaj, nqos khoom noj, Akkuzid yuav tsum tso tseg tam sim ntawd. Tus neeg mob yuav tsum tau txais kev kho kom zoo txaus thiab saib xyuas nws tus mob kom txog thaum cov tsos mob ntawm edema ploj, antihistamines tuaj yeem siv los txo lawv. Nrog kev mob caj dab ntsig txog tus mob txoj hlab pas, txoj kev tuag yuav tshwm sim tau. Yog tias, vim yog o ntawm lub suab nrov nrov, tus nplaig, lossis lub siab nqaj, kev txhim kho ntawm cov hlab pas tav tuaj yeem ua tau, tom qab ntawd kev kho mob hnyav tsim nyog yuav tsum tau nqa tawm, suav nrog kev tswj hwm subcutaneous ntawm kev daws teeb meem adrenaline ntawm qhov siab ntawm 1: 1000 (0.3-0.5 ml).

Hauv cov neeg mob uas tau mob caj dab dhau los uas tsis cuam tshuam nrog kev noj tshuaj Accuzide thiab ACE inhibitors, qhov ntxim nyiam ntawm nws txoj kev loj hlob ntxiv nrog kev siv cov tshuaj ntawm pawg no.

Kev nkag siab tuaj yeem ua rau txo qis ntshav tsawg dua cov ntshav siab, txawm li cas los xij, tsis muaj ib qho ntau dua li ntau dua li kev them nyiaj monotherapy nrog ob yam khoom xyaw. Feem ntau hypotension cuam tshuam nrog kev tsis yooj yim ntawm txoj hlab ntshav siab, tab sis nws kuj tuaj yeem txhim kho hauv cov neeg mob uas muaj BCC txo qis, piv txwv li, tom qab kho diuretic, vim kev noj zaub mov muaj ntsev tsawg lossis hemodialysis.

Yog tias muaj cov tsos mob ntawm txoj hlab ntshav ntawm txoj hlab ntshav liab, tus neeg mob yuav tsum pw. Yog tias tsim nyog, kev tso dej tshuaj ntawm 0.9% sodium tshuaj dawb tov yog nqa tawm. Kev hloov ntshav tsawg hauv ntshav tsis tas yuav tsum tshem tawm ntawm Akkuzid, txawm li cas los xij, kev hloov kho koob tshuaj yog tsim nyog.

Hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm nrog / tsis muaj lub raum ua rau lub raum khiav tsis zoo, kev noj cov tshuaj Accuzide tuaj yeem ua rau txo cov ntshav siab ntau ntxiv, nrog rau oliguria thiab azotemia. Hauv qee qhov tsis tshua muaj tshwm sim, txoj kev txhim kho ntawm lub raum tsis ua haujlwm thiab txawm tuag tau yog. Pawg neeg mob no yuav tsum tau txais kev saib xyuas mob nkeeg.

Tsis tshua muaj, Kev kho mob Accuzide tuaj yeem nrog kev txo qis ntawm granulocytes hauv cov ntshav mus rau theem tseem ceeb thiab txhawb kev mob hlwb pob txha hematopoiesis, thaum muaj pes tsawg tus leukocytes hauv cov ntshav yuav tsum raug tswj.

Cov tsos mob ntawm cov tsos mob me ntsis ntawm tus kab mob (kub taub hau, mob caj pas) qhia tias yuav tsum tau mus ntsib kws kho mob, vim tias lawv yuav qhia tias neutropenia.

Kev siv tshuaj tsis raug rau cov mob raum ua kom tsis zoo (kev tshem tawm cov ntshav muaj peev xwm tsawg dua 30 ml / min), vim tias azotemia thiab cov nyhuv loj tuaj yeem yog los ntawm kev siv lub sijhawm ntev.

Hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm hnyav, kev siv tshuaj ACE inhibitors tuaj yeem ua rau cov ntshav siab poob qis, uas yuav ua rau cov ntshav tso zis ntau ntxiv los ntawm lub raum thiab / lossis cov ntshav nce ntxiv ntawm cov khoom noj khoom haus ntawm cov khoom noj uas ua rau lub cev tau tso tawm los ntawm lub raum. Mob raum tsis ua haujlwm thiab / lossis kev tuag yuav tsis txiav txim tawm.

Thaum lub sijhawm kho nrog Accuside, ntshav siab, lub raum kev ua haujlwm, thiab cov ntshav ntshav feem ntau yuav tsum tau saib xyuas. Kev siv tib txhij ntawm quinapril thiab cov neeg sawv cev nquag tiv thaiv renin-angiotensin-aldosterone system (RAAS) yuav tsum zam. Qhov kev sib xyaw no tsuas yog tawm tswv yim rau qee tus neeg nyob rau hauv kev saib xyuas nruj ntawm lub raum kev ua haujlwm thiab ntshav qib plasma ntau ntau.

Hauv cov neeg mob uas tsis muaj peev xwm ua rau daim siab lossis mob siab rau daim siab mob siab, Kev nce qib tsheb nrawm yog siv nrog ceev faj, vim tias qhov kev hloov me me ntawm cov dej-electrolyte sib npaug yuav ua rau muaj kev loj hlob ntawm hepatic coma

Kwv yees li 2% ntawm cov neeg mob kho nrog quinapril muaj hyperkalemia. Kev siv ua ke ntawm Accuzide thiab potassium-sparing diuretics yog tsis pom zoo.

Cov tshuaj Chloride cuam tshuam nrog kev noj cov tshuaj Accuzide feem ntau yog mob me me thiab xav tau kev kho mob tshwj xeeb tsuas yog hauv qee kis (piv txwv li, nrog pathologies ntawm daim siab thiab / lossis ob lub raum).

Nyob rau hauv huab cua sov, noj Accuzide rau cov neeg mob uas muaj peripheral edema tuaj yeem ua rau kom cov sodium txo hauv lub cev tsawg dua. Tus mob no yuav tsum siv tshuaj kho.

Hinapril txo qis zoo tshaj ntawm cov calcium, ntxiv kev pom ntawm magnesium nyob rau hauv cov zis, uas tuaj yeem ua rau mob hypomagnesemia.

Quinapril tuaj yeem nce cov roj cholesterol, uric acid thiab triglycerides. Feem ntau cov kev cuam tshuam no yog mob me, txawm li cas los xij, qee qhov, lawv tuaj yeem ua rau kev txhim kho gout thiab ntshav qab zib.

Kev noj tshuaj kom ntau dua ntawm Accuzide tuaj yeem ua rau hyperkalemia (tshaj li ib koob ntawm ≥100 mg ib hnub), cuam tshuam kev tswj hwm ntawm cov ntshav qabzib hauv cov ntshav. Thaum kho txoj kev kho mob, nws raug nquahu kom tswj cov ntshav muaj ntshav qabzib thiab, yog tias tsim nyog, kho qhov kev kho ntshav qab zib.

Ua ntej kev phais mob, tus neeg mob yuav tsum ceeb toom tus kws kho mob tias nws tab tom noj Accuzide.

Thaum lub sij hawm kho cov tshuaj, kev txhim kho ntawm kev hnoos tsis tu ncua tau sau tseg. Nws kis tau tom qab nres cov tshuaj.

Hydrochlorothiazide tuaj yeem ua rau kev txhim kho ntawm lub kaum ntse ntse-kaw lub ntsej muag thiab lub myopia ib ntus. Yog tias tsis muaj kev kho kom tsim nyog, ib qho kev tiv thaiv tsis haum ntawm lub ntsej muag txhawm yog faus nrog tsis pom kev.

Cov poj niam ntawm kev muaj me nyuam thaum muaj hnub nyoog thaum siv Akkuzid yuav tsum muaj kev tiv thaiv los ntawm cev xeeb tub. Thaum nws pib, qhov tshuaj raug muab tso tseg sai li sai tau.

Thaum siv tshuaj kho nrog Accuside, kev ceev faj yuav tsum siv thaum ua cov haujlwm uas yuav tsum muaj kev saib xyuas ntau dua thiab nrawm ntawm lub cev kev xav, nrog rau kev tsav tsheb thiab lwm cov txheej txheem nyuaj, tshwj xeeb tshaj yog thaum pib kho.

Yeeb tshuaj sib cuam tshuam

• diuretics: muaj zog hypotensive nyhuv ntawm Akkuzid,
• ethanol, derivatives ntawm barbituric acid, narcotic analgesics: muaj kev pheej hmoo ntawm orthostatic vau,
• glucocorticosteroids (GCS), cov tshuaj hormones adrenocorticotropic (ACTH): cov tshuaj electrolytes ntau ntxiv, tshwj xeeb tshaj yog potassium,
• Digoxin: kev muaj peev xwm ntawm digoxin intoxication (nrog rau kev ua kom lub suab tsis sib xws),
• Kev siv tshuaj hypoglycemic: kev txhim kho hyperglycemia, muaj zog ntxiv nyob hauv qab,
• vasoconstrictor tshuaj: ib tug txo nyob rau hauv lawv cov nyhuv,
• tetracycline thiab lwm yam tshuaj uas cuam tshuam nrog magnesium: txo kev nqus ntawm lawv cov tshuaj nquag,
• cov tshuaj lithium: txo kev ua kom lub ntsej muag ntawm lub lithium, ntau ntxiv kev txhim kho cov kev tsis haum, kev pheej hmoo ntawm cov roj ntsha lithium,
• lwm cov tshuaj tiv thaiv kabmob: txhim kho lawv cov kev ua, tshwj xeeb tshaj yog beta-blockers thiab ganglion blockers,
• non-steroidal anti-inflammatory tshuaj (NSAIDs): kev ua kom tsis muaj zog ntawm hypotensive, diuretic, natriuretic kev ua ntawm Accuzide, lub raum tsis ua haujlwm hauv cov neeg laus, nrog rau txo BCC thiab lub raum tsis ua haujlwm,
• tshuaj uas nce qib ntawm cov poov tshuaj nyob rau hauv cov ntshav: ib qho kev nce siab hauv kev muaj peev xwm ntawm kev txhim kho hyperkalemia,
• ion txauv resins: hnov ​​tsis haum ntawm hydrochlorothiazide,
• tshuaj tiv thaiv mob gout: kev tswj tsis zoo ntawm cov xwm txheej ntawm cov neeg mob gout, qhov nce ntxiv ntawm qhov mob tsis haum lub cev tiv thaiv kab mob gout,
• Cov tshuaj narcotic, narcotic analgesics, tshuaj rau txo ntshav siab: muaj txiaj ntsig hypotensive ntawm Accuzide,
• cov tshuaj tiv thaiv kab mob, cytostatics, allopurinol, procainamide: muaj kev pheej hmoo ntawm kev tsim leukopenia,
• mob glycosides thiab lwm yam tshuaj uas tuaj yeem ua rau pirouette hom arrhythmias: muaj kev pheej hmoo ntawm hypokalemia, muaj tshuaj lom muaj zog,
• aliskiren: qhov tshwm sim ntawm kev thaiv ob zaug ntawm RAAS kev ua haujlwm, uas pom los ntawm kev txo ntshav siab, hloov hauv lub raum kev ua haujlwm, hyperkalemia,
• mTOR thiab DPP-4 enzyme inhibitors: nce ntau ntxiv ntawm kev tsim Quincke edema.