Yuav siv cov tshuaj Glyclazide li cas? > Kev khomob thiab kev tiv thaiv

Daim ntawv tshuaj - koob tshuaj: tiaj-cylindrical, yuav luag dawb lossis dawb, nrog kev pheej hmoo thiab bevel (10 txhua qhov hauv cov hlwv pob, nyob rau hauv ib pob ntawm cardboard 3 lossis 6 pob thiab cov lus qhia rau kev siv Gliclazide).

Composition 1 ntsiav tshuaj:

cov tshuaj nquag: gliclazide - 80 mg,
Cov khoom sib xyaw: cov hmoov txhuv nplej siab 1500 (cov hmoov txhuv nplej ua ntej pob kws), sodium lauryl sulfate, lactose monohydrate, magnesium stearate, croscarmellose sodium.

Cov Tshuaj Hauv Tshuaj

Glyclazide - ib qho sulfonylurea derivative ntawm lub cim thib ob, tus neeg sawv cev hypoglycemic.

Tus txheej txheem ntawm kev ua ntawm cov tshuaj yog vim muaj peev xwm los txhawb lub zais cia ntawm pancreatic insulin, nce insulin-secretory nyhuv ntawm cov piam thaj, thiab nce rhiab ntawm cov ntaub so ntswg mus rau insulin. Gliclazide stimulates kev ua ub no ntawm intracellular enzymes xws li mob glycogen synthetase. Txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov kom pib lub insulin secretion. Tsis zoo li lwm yam sulfonylurea derivatives, nws rov tsim kho lub hnub nyoog thaum ntxov hauv insulin secretion. Txo tom qab postprandial hyperglycemia.

Gliclazide tau zoo nyob rau hauv kev mob ntshav qab zib metabolic thiab latent ntshav qab zib mellitus, suav nrog cov neeg mob uas muaj kev rog rog exogenously. Kev kho tsis tu ncua ntawm cov ntawv glycemic tau sau tseg ob peb hnub tom qab pib kev kho mob. Cov tshuaj tiv thaiv kev loj hlob ntawm microvasculitis, nrog rau kev puas tsuaj rau retina ntawm lub qhov muag. Txhawb kev platelet aggregation. Nce fibrinolytic thiab heparin kev ua si, nrog rau kev ua pa rau heparin. Tseem ceeb nce tus txheeb cais kev cais cais. Nws tso tawm cov dej num ua antioxidant, txhim kho vascularization.

Nrog tus mob ntshav qab zib nephropathy, proteinuria tsawg dua. Nrog rau siv ntev, nws pab txo qis proteinuria hauv cov neeg mob ntshav qab zib nephropathy.

Txij li thaum cov tshuaj muaj cov txiaj ntsig tseem ceeb ntawm cov tshuaj tiv thaiv thaum ntxov thiab tsis ua rau hyperinsulinemia, nws tsis ua rau nce hauv lub cev qhov hnyav. Ntxiv mus, hauv cov neeg mob rog, gliclazide pab rau kom poob phaus, raug rau cov zaub mov tsis muaj calorie ntau.

Nws muaj cov haujlwm ua haujlwm antiatherogenic, txo cov ntsiab lus ntawm tag nrho cov roj (cholesterol) hauv cov ntshav.

Lub antioxidant thiab hemovascular cov yam ntxwv ntawm gliclazide pab txo kev pheej hmoo ntawm kev tsim cov vascular muaj teeb meem rau cov neeg mob ntshav qab zib mellitus.

Cov Tshuaj Pharmacokinetics

Gliclazide yog tus cwj pwm los ntawm kev nqus siab. Tom qab qhov ncauj tawm ntawm 40 mg, qhov siab tshaj plaws (C_max) tau sau tseg tom qab 2-3 teev thiab tau ntau npaum li 2-3 μg / ml, tom qab noj 80 mg, qhov ntsuas no yog 4 teev thiab 2.2–8 μg / ml, feem.

Kev sib txuas nrog cov plasma protein yog 85-97%, cov khoom faib yog 0.35 l / kg. Kev ua kom sib npaug sib luag tau mus txog hauv 2 hnub.

Gliclazide yog metabolized hauv lub siab nrog kev tsim ntawm 8 metabolites. Tus nqi ntawm cov tshuaj metabolite tseem ceeb yog 2-3% ntawm tag nrho cov koob tshuaj, nws tsis muaj hypoglycemic, tab sis nws cuam tshuam microcirculation.

Ib nrab-lub neej (T_½) - 8-12 teev .Thov cov tshuaj tau tawm hauv lub raum feem ntau: 70% - nyob rau hauv daim ntawv ntawm metabolites, tsis pub ntau tshaj 1% - tsis hloov pauv. Txog 12% ntawm gliclazide raug ntaws los ntawm cov hnyuv ua cov khoom noj metabolites.

Muaj qee qhov tsis haum:

lub raum thiab lub siab ua haujlwm: nyob rau hauv kev mob ntshav siab thiab mob raum tsis zoo, kev hloov pauv hauv pharmacokinetics ntawm gliclazide yog ua tau, ntu kev mob ntshav qab zib nyob hauv cov neeg mob zoo li no yuav ntev dua, uas yuav tsum muaj kev ntsuas txaus,
lub hnub nyoog dhau los: tsis muaj cov yam ntxwv pharmacokinetic tau pom.

Cov Yuav Tsum Muaj

yam 1 mob ntshav qab zib mellitus (suav nrog hom hluas)
ntshav qab zib hyperosmolar precoma thiab coma,
mob ketoacidosis,
hypo- thiab hyperthyroidism,
mob raum thiab / lossis daim siab ua haujlwm,
dav dav raug mob thiab kub hnyiab,
galactose intolerance, lactase deficiency, qabzib-galactose malabsorption,
hnub nyoog txog 18 xyoo
cev xeeb tub thiab lactation
siv cov miconazole kom nruj,
hypersensitivity rau ib qho twg ntawm cov tshuaj, sulfonamides lossis lwm yam tshuaj ntawm sulfonylurea pawg.

Nws tsis pom zoo siv Gliclazide siv nrog danazol, phenylbutazone, ethanol.

Gliclazide, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Glyclazide ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj nrog zaub mov.

Thaum pib kho, 80 mg (1 ntsiav tshuaj) feem ntau yog 1 teev nyob rau ib hnub. Yav tom ntej, tus kws kho mob xaiv cov tshuaj txij nkawm rau nws ib leeg, nws tuaj yeem yog 80-320 mg ib hnub. Ib koob tshuaj yuav tsum tsis pub ntau tshaj 160 mg. Thaum sau ntawv yuav tsum tau noj tshuaj ntau, koj yuav tsum noj cov tshuaj 2 zaug hauv ib hnub thaum noj mov loj.

Qhov pom zoo kom pib noj rau cov neeg mob laus (tshaj 65 xyoo) yog 40 mg (½ ntsiav tshuaj) ib hnub ib zaug. Yog tias tsim nyog, txuas ntxiv qhov koob tshuaj yuav raug nce siab. Kev nce ntxiv ntawm cov tshuaj yuav tsum tau ua nyob rau ntawm lub sijhawm tsawg kawg 14 hnub nyob rau hauv kev tswj hwm ntawm cov ntshav qabzib hauv cov ntshav.

Hauv cov tshuaj txhua hnub (40-80 mg), Gliclazide pom zoo rau cov neeg mob raum / hepatic tsis txaus, cov neeg mob debilitated, thiab tseem muaj cov neeg mob uas muaj mob ntshav qab zib: mob hnyav lossis tsis zoo los ntawm cov kev mob endocrine (suav nrog hypothyroidism, adrenal thiab pituitary insufficiency), mob vascular mob heev (nrog rau cov kab mob ntshav siab txaus rau lub plawv, mob atherosclerosis, mob atherosclerosis ntawm cov hlab ntsha hauv ntshav liab), ua kom tsis txaus los yog noj tsis txaus, peri Kev tshem tawm ntawm glucocorticosteroids tom qab lawv kev ua haujlwm ntev thiab / lossis kev tswj hwm hauv siab.

Thaum hloov chaw rau tus neeg mob mus rau Glyclazide los ntawm lwm tus neeg sawv cev rau qhov ncauj ntshav hypoglycemic, lub sijhawm hloov pauv tsis tas yuav tsum muaj. Nyob rau hauv rooj plaub ntawm kev hloov pauv ntawm lwm qhov sulfonylurea npaj nrog lub sijhawm ntev ib nrab-piv txwv (piv txwv, chlorpropamide) los ntawm gliclazide, ua tib zoo saib xyuas tus neeg mob yuav tsum tau ua kom tsis txhob muaj kev txhim kho ntawm cov nyhuv ntxiv thiab ntshav qab zib.

Yog tias tsim nyog, Gliclazide tuaj yeem raug sau ua ke nrog insulin, alpha-glucosidase inhibitors thiab biguanides.

Cov neeg mob uas siv Glyclazide tsis txaus tswj theem ntawm cov piam thaj hauv cov ntshav yuav raug muab tshuaj insulin. Txoj kev kho yuav tsum tau ua nyob rau hauv kev saib xyuas nruj ntawm tus kws kho mob.

Yog tias koj tsis nco qab noj ntxiv, nws yuav raug txwv tsis pub noj ob npaug hnub tom qab.

Ua raws li cov tib neeg cov tshuaj tiv thaiv metabolic (cov ntshav qabzib, glycated hemoglobin) ntawm tus neeg mob, cov koob tshuaj ntawm cov tshuaj thaum kho tuaj yeem hloov kho.

Sab sij huam

los ntawm lub plab zom mov: mob plab, mob plab / cem quav, xeev siab, ntuav (qhov mob ntawm cov tsos mob no yuav txo qis yog tias koj noj tshuaj nrog zaub mov),
nyob rau ntawm daim siab thiab kab mob biliary: nce kev ua haujlwm ntawm daim siab enzymes, mob cholestatic daj ntseg, kab mob siab,
los ntawm cov ntshav hemopoietic plab hnyuv siab raum: leukopenia, thrombocytopenia, anemia, granulocytopenia,
los ntawm cov hlab plawv: epistaxis, mob ntshav ncig lub plawv, cerebrovascular tsis txaus, mob hlab ntsha, mob plab, mob lub plawv, tachycardia, myocardial infarction, ceg o, mob thrombophlebitis,
nyob rau ib feem ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: cov tsis pom kev tsis pom kev zoo (feem ntau thaum pib kho),
kev ua xua: pruritus, erythema, tawm pob ntawm daim tawv nqaij (nrog rau kev ua xua thiab maculopapular), urticaria, kev tsis haum vasculitis, angioedema.

Cov tsos mob tseem ceeb ntawm kev mob ntshav qab zib: tsaug zog, nkees, mob taub hau, kiv taub hau, tsis muaj zog, tawm hws, poob siab, mob plab, tshee tshee, tshee tshee, xeev siab, ntuav. Cov kev tshwm sim hauv qab no tseem muaj peev xwm ua tau: kev tshaib kev nqhis, lub siab tsis tuaj yeem, kev ntxhov siab, pw tsaug zog, ntxhov siab, hais lus thiab pom kev tsis sib haum xeeb, maj mam nqes rov qab, tsis meej pem, kev xav tsis muaj zog, hnov lub suab tsis zoo, paresis, mob siab, delirium, plam ntawm kev tswj tus kheej, ua kom mob, ua kom npau taws, ua pa nyuaj. , kev nyuaj siab, tsis nco qab. Kev mob ntshav qab zib tsawg tuaj yeem ua rau tsis nco qab thiab tuag. Qee tus neeg mob qhia cov cim ntawm adrenergic txee-kev cai: tawm hws, tawv nqaij, tawv tsaj, ntxhov siab, ntshav siab, angina pectoris, tachycardia, mob plawv dhia tsis xwm yeem - cov tsos mob no feem ntau ploj tom qab noj carbohydrates.

Noj ntau dhau

Nyob rau hauv cov ntaub ntawv ntawm overdose, hypoglycemia feem ntau tsim.

Rau cov tsos mob muaj txiaj ntsig, koj yuav tsum nce nqi ntawm cov carbohydrates hauv zaub mov, txo qhov ntau ntawm Gliclazide thiab / lossis kho cov zaub mov noj. Mus txog rau thaum tus mob sawv khov kho tag, tus neeg mob yuav tsum tau kev saib xyuas mob nkeeg.

Kev mob ntshav qog ntshav siab heev tuaj yeem nrog ua kom ntog, coma thiab lwm yam kev mob hlwb. Cov neeg mob zoo li no tau txais kev kho mob kub ceev, yuav tsum tau mus pw hauv tsev kho mob sai.

Yog tias qhov mob ntshav qab zib tsis hnov qab yog qhov xav tau lossis tsim, qhov kev txhaj tshuaj rau 50 ml ntawm 20-30% kev daws teeb meem ntawm dextrose (qabzib) yog qhia. Tom ntej no, txau ntawm 10% dextrose kev daws teeb meem yog qhov tsim nyog los tswj kom cov ntshav cov ntshav nyob siab tshaj 1 g / l. Tsawg kawg ntawm ob hnub yuav tsum ua tib zoo saib xyuas. Txoj kev kho yuav tsum nrog saib xyuas thiab tswj cov haujlwm tseem ceeb ntawm lub cev.

Kev lim ntshav tsis muaj txiaj ntsig vim tias gliclazide khi rau ntau yam kom cov plasma protein.

Cov lus qhia tshwj xeeb

Txhawm rau kom tsis txhob muaj kev pheej hmoo ntawm kev mob hypoglycemic qaug dab peg, tus kws kho mob yuav tsum ua tib zoo xaiv cov koob tshuaj Glyclazide, muab cov neeg mob pom tseeb rau kev noj tshuaj, thiab saib xyuas kev ua raws li cov lus qhia no.

Gliclazide tsuas yog kho tau rau cov neeg mob uas tuaj yeem muab cov zaub mov noj tsis tu ncua, suav nrog noj tshais. Qhov tseem ceeb ntawm kev noj zaub mov carbohydrate yog vim muaj kev pheej hmoo ntawm cov ntshav qab zib tsawg yog hais txog kev noj zaub mov qeeb, tsis txaus noj ntau npaum li cas lossis cov ntsiab lus carbohydrate tsawg. Txoj kev pheej hmoo ntawm cov ntshav qog ntshav qab zib nce ntxiv nrog kev noj zaub mov kom tsis muaj calorie, haus cawv, noj ib txhij ntawm ntau cov tshuaj los ntawm cov pab pawg sulfonylurea, zoo li tom qab ntev lossis kev siv lub cev ntau dhau. Kev mob ntshav qab zib tuaj yeem tawm tsam ntev thiab mob hnyav, uas yuav tsum tau pw hauv tsev kho mob ntawm tus neeg mob thiab qhia txog cov kua nplaum ntev li ob peb hnub.

Kev mob ntshav khov ntau heev yog ua tau thaum noj ib yam tshuaj sulfonylurea. Cov neeg mob uas qaug zog thiab emaciated, cov laus neeg laus, cov neeg mob adrenal tsis txaus (ob qho tib si thawj thiab theem nrab) yog qhov tshwj xeeb tshaj yog raug tau.

Cov neeg mob thiab lawv tsev neeg yuav tsum piav qhia txog qhov txaus ntshai ntawm lub qog ntshav qab zib, tham txog lawv cov tsos mob thiab cov txheej txheem kho, thiab tseem piav qhia txog yam tseem ceeb rau kev txhim kho ntawm tus mob no. Tus neeg mob yuav tsum nkag siab meej txog qhov tseem ceeb ntawm kev noj haus, kev tawm dag zog kom tsis tu ncua thiab kev saib xyuas cov ntshav qabzib kom tsis tu ncua. Cov neeg mob ntshav qab zib yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib ntau tsam muaj kev tshaib plab, haus cawv thiab tsis siv tshuaj tiv thaiv kab mob.

Cov tsos mob ntawm kev mob ntshav qab zib feem ntau ploj mus tom qab noj zaub mov uas muaj carbohydrate, xws li qab zib. Cov txiv ntoo qab zib tawm mus tsis tau. Txawm tias pib pab cawm tau tus mob zoo, hypoglycemia yuav rov muaj mob dua. Yog tias pom muaj cov tsos mob hnyav lossis mob ntev, txawm tias tom qab kev txhim kho ib ntus nrog kev noj zaub mov carbohydrate, yuav tsum muaj kev kho mob, suav nrog tsev kho mob.

Qhov ua tau zoo ntawm cov ntshav qabzib tswj lub sijhawm thaum noj tshuaj tiv thaiv kab mob tuaj yeem txo qis hauv qab ntawm cov yam hauv qab no: ua npaws, mob hnyav, phais, raug mob, ntxhov siab. Hauv qee kis, kev qhia txog cov tshuaj insulin kuj xav tau.

Qhov ua tau zoo ntawm Gliclazide ntsiav tshuaj, zoo ib yam li lwm qhov ncauj tshuaj hypoglycemic, txo lub sijhawm. Qhov ua rau muaj cov xwm txheej no tuaj yeem yog kev nce qib mob ntshav qab zib lossis kev qaug zog ntawm cov tshuaj. Qhov tshwm sim no yog hu ua theem nrab ntawm qhov tshwm sim ntawm kev kho mob, hauv kev sib piv rau thawj qhov tsis muaj txiaj ntsig thaum pib siv yeeb tshuaj. Qhov xaus hais txog kev ua haujlwm tsis muaj txiaj ntsig theem nrab tsuas yog ua tau tom qab kev kho kom haum lub koob tshuaj thiab saib xyuas cov neeg mob ua raws li kev noj haus.

Hauv cov neeg mob uas tsis muaj cov piam thaj-6-phosphate dihydrogenase, cov tshuaj los ntawm cov pab pawg sulfonylurea, suav nrog glycazide, tuaj yeem ua rau txoj kev loj hlob ntawm hemolytic anemia. Hauv qhov no, nws raug nquahu kom xav txog qhov ua tau ntawm lwm txoj kev kho mob nrog rau tshuaj ntawm lwm chav kawm lossis thov siv Glyclazide nrog kev ceev faj.

Thaum siv Gliclazide, nws yog qhov yuav tsum tau ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, daim siab, kab mob plawv, nrog rau cov xwm txheej ophthalmic. Thaum kuaj xyuas cov ntshav cov piam thaj, nws raug nquahu kom ntsuas cov ntsiab lus ntawm glycated hemoglobin (lossis cov piam thaj hauv cov ntshav txhaws ntawm cov ntshav ntshav). Ib qho ntxiv, kev saib tus kheej ntawm cov ntshav qab zib ua si yuav muaj txiaj ntsig zoo rau cov neeg mob.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Gliclazide tsis cuam tshuam lossis cuam tshuam rau qhov kev xav ntawm tib neeg lub hlwb. Txawm li cas los xij, thaum lub sijhawm kho, tshwj xeeb tshaj yog thaum pib ntawm txoj kev kho, cov tsav tsheb thiab cov neeg ua haujlwm hauv cov lag luam uas muaj feem yuav tsum ceev faj txog qhov muaj kev pheej hmoo ntawm lub qog ntshav qab zib.

Cev xeeb tub thiab lactation

Muaj ob peb cov ntaub ntawv tshawb fawb hais txog kev siv gliclazide thaum cev xeeb tub. Muaj cov ntaub ntawv qhia txog kev siv lwm cov sulfonylurea npaj.

Hauv cov kev tshawb fawb tsiaj, muaj kev qhia txog kev muaj me nyuam yaus muaj zog thaum muaj qhov siab ntau ntawm gliclazide tau pom.

Raws li kev ceev faj, cov tshuaj tsis pom zoo rau cov poj niam cev xeeb tub. Txawm li cas los xij, txhawm rau zam kom tsis txhob tsim cov kabmob phem ntawm cov menyuam yaus, kev ceev faj saib xyuas ntshav qab zib hauv niam yuav tsum ua. Cov tshuaj tiv thaiv kab mob rau hauv qhov ncauj tsis yog siv rau hauv cov poj niam cev xeeb tub, insulin yog qhov tshuaj ntawm xaiv. Thaum npaj kev cev xeeb tub thiab yog tias muaj menyuam hauv plab thaum noj cov tshuaj gliclazide, nws raug nquahu kom hloov cov tshuaj ntawm qhov ncauj nrog kev kho mob.

Nws tsis paub meej tias cov tshuaj nkag mus rau leej niam cov kua mis, muaj feem rau qhov no, Glyclazide yog contraindicated thaum lactation.

Yeeb tshuaj sib cuam tshuam

Kev siv cov tshuaj miconazole uas ua rau pom tseeb yog sib kis (hauv cov txheej txheem tshuaj rau lub cev lossis hauv daim ntawv rau lub ntsej muag rau daim ntawv thov rau cov leeg ntawm lub qhov ncauj ntawm qhov ncauj), txij li nws txhim kho cov nyhuv ntawm gliclazide thiab, vim li ntawd, nce qhov kev pheej hmoo ntawm hypoglycemia ntau heev, nce txog lub cev tsis nco qab.

Tsis pom zoo ob peb ua ke:

phenylbutazone (hauv cov ntawv ntau npaum li cas rau kev siv systemic): txhim kho cov nyhuv hypoglycemic ntawm sulfonylureas. Lwm qhov tshuaj tiv thaiv kev tiv thaiv mob tau pom zoo. Yog tias lub hom phiaj ntawm kev sib koom ua ke yog qhov tseeb hauv cov chaw kho mob, cov ntshav qabzib yuav tsum tau saib xyuas ntau dua, yog tias tsim nyog, kho qhov tshuaj glycoslazide (ob qho tib si thaum muaj kev sib xyaw thiab tom qab phenylbutazone thim tawm),
ethanol: zoo heev txhim kho hypoglycemia thiab tuaj yeem ua rau hypoglycemic coma.Rau lub sijhawm ntawm kev kho, koj yuav tsum tso tseg kev haus cawv thiab noj cov tshuaj cawv uas muaj ethanol,
danazol: muaj cov nyhuv ntshav qab zib; nws txoj kev tswj hwm tsis pom zoo thaum kho hypoglycemic. Txawm li cas los xij, yog tias kev tswj hwm yog tsim nyog, qhov tshuaj ntawm Gliclazide yuav tsum tau kho.

Kev sib xyaw ua ke xav tau kev ceev faj:

lwm cov kab mob hypoglycemic (insulin, acarbose, biguanides), beta-blockers, angiotensin-hloov enzyme inhibitors (enalapril, captopril), fluconazole, histamine H blockers₂-tawm siv tshuaj, sulfonamides, tshuaj tsis-steroidal los tiv thaiv cov tshuaj, tshuaj chlorpromazine siab, tshuaj monoamine oxidase inhibitors: txhim kho cov nyhuv hypoglycemic thiab nce qhov kev pheej hmoo ntawm hypoglycemia. Ua tib zoo glycemic tswj thiab koob tshuaj xaiv ntawm Gliclazide pom zoo.
tetracosactide, glucocorticosteroids rau cov kab ke thiab hauv zos (intraarticular, subcutaneous, cutaneous, lub qhov quav) siv: nce ntshav qabzib nrog txoj kev loj hlob ntawm ketoacidosis (txo qis rau hauv siab rau cov carbohydrates). Ua tib zoo glycemic tswj yog qhov tsim nyog, tshwj xeeb tshaj yog thaum pib ntawm kev kho ntshav qab zib, thiab kev kho tshuaj glycazide,
beta₂-adrenomimetics (terbutaline, salbutamol, ritodrine): nce ntxiv ntshav qabzib, yog li cov ntshav qabzib yuav tsum tau soj ntsuam kom zoo. Tuaj yeem hloov chaw ntawm tus neeg mob rau insulin,
gliclazide thiab lwm yam sulfonylurea derivatives: anticoagulants yuav ua kom zoo dua, uas yuav tsum tau kho kom haum.

Kev tshuaj xyuas txog Gliclazide

Raws li kev txheeb xyuas, Gliclazide yog ib qho muaj txiaj ntsig rau kev ua rau tiv thaiv kab mob. Tam sim no, derivatives ntawm sulfonylureas ntawm lub cim thib ob yog siv dav, txij li lawv tau zoo dua rau lub sijhawm yav dhau los hauv kev kawm ntawv ntawm hypoglycemic effect, thiab nws yog qhov ua tau kom ua tiav zoo dua thaum siv tshuaj tsawg dua. Ntxiv rau, cov nyiaj hauv cov pab pawg no tsis tshua pom kev phiv.

Cov kws kho mob tshaj tawm qhia tias thaum lub sijhawm biotransformation ntawm gliclazide, ib qho tshuaj metabolite kuj tau tsim, uas muaj cov txiaj ntsig zoo ntawm microcirculation. Ntau cov kev tshawb fawb tau ua pov thawj tias cov tshuaj txo cov kev pheej hmoo ntawm microvascular (nephropathy, retinopathy), kev txhim kho angiopathy. Tsis tas li ntawd, nws txhim kho conjunctival khoom noj khoom haus, tshem tawm vascular stasis. Hauv qhov no, kev xaiv ntawm Gliclazide yog qhov zoo tshaj rau kev mob ntshav qab zib xws li pib mob raum tsis ua haujlwm, nephropathy, retinopathy thiab angiopathy.

Muaj cov ntawv tshaj tawm tias ob peb xyoos (3-5 xyoos) tom qab pib kev noj tshuaj, muaj lub siab xav rau txoj kev kho txo qis. Hauv cov xwm txheej zoo li no, yuav tsum tau teem caij ntxiv ib tus neeg sawv cev hypoglycemic ntxiv.

Glyclazide ntsiav tshuaj

Kev npaj tshuaj hypoglycemic qhov ncauj, uas yog ib tug khaws cia ntawm lub cim thib ob sulfonylurea, muaj ntau yam ntawm cov tshuaj kho mob muaj txiaj ntsig. Glyclazide muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 80 mg lossis 30 thiab 60 mg nrog kev hloov pauv. Cov tshuaj muaj pov thawj ua haujlwm zoo, yog li ntawd, nws tau feem ntau tau sau tseg txhawm rau ua kom cov ntshav qabzib hauv lub cev.

Glyclazide 30 mg ntsiav tshuaj muaj puag ncig, tiaj-cylindrical duab, muaj chamfer, xim yog xim dawb lossis yuav luag dawb (daj lossis greyish zas). Kev noj tshuaj ntawm 60 mg yog qhov muaj kev pheej hmoo. Cov tshuaj yeeb tshuaj yog gliclazide. Cov tshuaj muaj pes tsawg leeg:

gliclazide-30 lossis 60 mg

silicon dioxide colloidal

sodium stearyl fumarate

Kev ntsuas rau siv

Cov tshuaj Gliclazide yog siv dav rau hom 2 mob ntshav qab zib thiab hyperglycemia. Kev txais tos yog tshwj xeeb tshaj yog thaum tsis tshua muaj kev ua tau zoo ntawm kev qhia txog kev noj zaub mov noj, txoj hauv kev rau kev txo lub cev qhov hnyav thiab cov kev tawm dag zog tshwj xeeb. Glyclazide muaj txiaj ntsig zoo rau kev tiv thaiv kev cuam tshuam ntawm hom 2 mob ntshav qab zib mellitus: kev txhim kho ntawm microvascular pathologies (mob stroke, myocardial infarction) thiab microcirculatory ntshawv siab (retinopathy, nephropathy).

Cov lus qhia rau kev siv Gliclazide

Qhov kev txiav txim siab ntawm qhov ntau npaum li cas rau kev tuaj yeem nrog hyperglycemia yog txiav txim siab raws li cov txheej txheem: hnub nyoog, mob ntshav qab zib, thiab cov ntshav qab zib ua ntej noj thiab ob teev tom qab noj mov. Cov koob tshuaj pom zoo thawj zaug yog 40 mg nrog zaub mov noj. Qhov tshuaj no tau pom zoo rau txhua tus neeg mob, suav nrog cov laus. Qhov hno tshuaj ua ntej txhua hnub yog 80 mg. Ntxiv mus, nyob ntawm qhov ntsuas, qhov nruab nrab 160 mg ib hnub. Cov koob tshuaj hloov kho tau coj tawm mus rau hauv qhov kev txiav txim siab tsawg kawg ob-lub lim tiam.

Qhov siab kawg pub rau tau noj yog - 320 mg. Yog tias koj hla kev noj cov tshuaj, koj tsis tas yuav nce qhov ntxiv rau hnub tom qab. Cov tshuaj rau cov neeg laus, nrog rau cov neeg mob raum tsis ua haujlwm, tsis txawv. Kev noj cov tshuaj yuav tsum tuaj yeem nrog cov kev tswj hwm ntawm cov ntshav qabzib kom thiaj li tiv thaiv tau ntshav qog ntshav (nce siab nyob hauv qab).

Glyclazide MV 30 mg

Cov hloov kho-tso tawm (MV) koob tshuaj ntawm Gliclazide tuaj yeem ntev txog 30 txog 120 mg. Kev txais tos yuav nyob rau yav sawv ntxov nrog zaub mov. Yog tias koj hla kev noj tshuaj rau hyperglycemia, kev them nyiaj raug txwv los ntawm nce qhov koob tshuaj rau hnub tom qab. Qhov ntau npaum cov tau txiav txim siab yog ua ib tus zuj zus. Qhov hno koob yog 30 mg. Thaum tsis ua tiav ntawm qhov tshwm sim, lub koob tshuaj maj mam (ib hlis ib zaug) nce mus txog 60, 90 thiab 120 mg. Gliclazide MB tuaj yeem ua ke nrog cov tshuaj insulin. Cia peb xav tias qhov kev hloov pauv zoo los ntawm kev noj cov pa Gliclazide 80 mus rau Gliclazide MV 30 mg tom qab qab zib chaw thau khoom.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Cov tshuaj yuav tsum cia nyob hauv qhov chaw tsaus uas tsis muaj ya raws ntawm qhov kub ntawm qhov tsis siab tshaj 25 degrees. Gliclazide yuav tsum muaj kev tiv thaiv los ntawm menyuam yaus. Txee lub neej yog peb xyoos. Tso tawm los ntawm kev kho mob.

Hauv kev lag luam hauv khw muag tshuaj muaj ntau yam duab ntawm Gliclazide. Qee qhov ntawm lawv muaj cov tshuaj zoo ib yam, lwm qhov tso cai kom ua tiav cov nyhuv kho zoo sib xws. Cov tshuaj hauv qab no yog cov duab noj tshuaj sib piv:

Glyclazide Canon,
Glidia MV,
Gluconorm,
Gliklada
Lub Neej
Cauj
Lawj xeeb
Diabresid
Kev kuaj mob.

Cov ntaub ntawv pharmacological ntawm cov tshuaj

Kev siv tshuaj hypoglycemic rau kev tswj hwm qhov ncauj. Ib qho khoom lag luam yog tsim los ua cov ntawv nyeem ntawm sulfonylurea thib ob tiam. Pab kev tsim cov tshuaj insulin los ntawm cov kab mob hlwb. Tsub qhov rhiab heev ntawm peripheral cov ntaub so ntswg rau insulin. Txo cov sijhawm tsis txaus nyob nruab nrab ntawm cov pluas noj thiab pib ua cov insulin ntau lawm.

Tsuas tshuaj thiab muaj pes tsawg leeg ntawm cov ntsiav tshuaj "Gliclazide"

Thaum nws nkag mus rau hauv lub plab, cov tshuaj tau tawg sai heev hauv nws cov kab noj hniav. Tom qab 4 teev, 80 mg nkag mus rau hauv cov hlab ntshav nrog ib zaug tshuaj ntawm cov tshuaj. Yuav luag 100% txuas nrog cov protein ua kom ntshav. Nws yaj hauv lub siab thiab daim ntawv metabolites uas tsis muaj cov cuab yeej hypoglycemic, tab sis tuaj yeem cuam tshuam rau microcirculation nkaus xwb. Nws yog tawm hauv cov zis thaum nruab hnub.

Thaum pib kho, 80 mg yog sau tseg ib hnub ib zaug. Qhov siab tshaj plaws yuav noj tau 160-220 mg ib hnub ob zaug. Cov ntsiav tshuaj yuav qaug ua ntej noj mov. Tsis tas li, qhov ntau npaum li cas yog nyob ntawm chav kawm ntawm tus kab mob thiab qhov degree ntawm kev puas tsuaj rau tus kab mob nqaj hlau. Koj tuaj yeem muab qhov txais tos. Ib ntsiav tshuaj noj rau lub plab tas, thiab ob teev tom qab noj mov tas, rov qab muab qhov ntau npaum. Yuav siv cov "Glyclazide" li cas? Cov lus qhia rau kev siv. Nqe, analogues, cov tshuaj yog - tus kws kho mob yuav qhia txog txhua yam no.

Kev cuam tshuam nrog lwm yam tshuaj

Glyclazide ntsiav tshuaj poob lawv cov txiaj ntsig thaum noj ua ke nrog qee yam tshuaj. Cov no yog pyrazolone derivatives, tshuaj tua kabmob sulfonamide, MAO inhibitors, theophylline, caffeine.

Nrog rau kev tswj hwm tib lub sij hawm nrog cov kev xaiv tsis raug beta-blockers, kev txhim kho hypoglycemia nce, tachycardia thiab tshee tshee tshee, tawm hws, tshwj xeeb tshaj yog thaum tsaus ntuj, yuav tshwm sim.

Thaum siv cov tshuaj muaj cov tshuaj "Cimetidine" hauv cov ntshav, cov ntsiab lus ntawm "Gliclazide" cov ntsiav tshuaj nce. Qhov no tuaj yeem ua rau ua rau ntshav muaj ntshav qab zib siab heev. Nrog rau kev tswj hwm tib lub sij hawm ntawm Glyclazide ntsiav tshuaj thiab tshuaj Veropomila, nws tsim nyog los tswj cov ntshav qab zib hauv cov ntshav.

Kuj, nrog rau kev noj GCS, Glyclazide ntsiav tshuaj txo qis lawv cov khoom hypoglycemic. Cov tshuaj no suav nrog diuretics, barbiturates, estrogens, thiab qee cov tshuaj tiv thaiv TB. Yog li, nws tsim nyog soj ntsuam kev ua tiav ntawm lub cev ua ntej noj cov tshuaj "Gliclazide." Cov lus qhia rau kev siv, tus nqi, analogues, cov kev mob tshwm sim - txhua qhov no yuav tsum paub ua ntej.

Kev qhia rau noj Glyclazide ntsiav tshuaj

Cov tshuaj tau tawm rau cov ntshav qab zib mellitus ntawm yam thib ob ntawm kev mob nyhav ib nrab, thaum tseem tsis tau muaj qhov tsis txaus insulin. Kuj rau kev tiv thaiv kev ntsuas rau cov kev puas tsuaj microcirculatory. Cov tshuaj yog siv nyob rau hauv kev saib xyuas ntawm kws kho mob. Ua ntej koj yuav tsum kuaj ntshav qab zib. Nco ntsoov ua raws cov zaub mov noj thaum kho mob, txo qis cov ntsev thiab carbohydrates kom tsawg. Tsis kam txais hmoov nplej thiab qab zib.

Gliclazide mv

Glyclazide mv ntsiav tshuaj tau ua pov thawj lawv tus kheej. Cov lus qhia rau kev siv yuav qhia txog contraindications thiab phiv los ntawm cov tshuaj no. Nws siv los kho cov ntshav qab zib uas tsis yog insulin-mob ntshav qab zib mellitus nrog mob hnyav. Koj tsis tuaj yeem haus cov tshuaj no rau ntshav qab zib ntawm thawj hom, nrog pathologies ntawm daim siab thiab lub raum. Thaum cev xeeb tub thiab lactation, noj cov tshuaj yog nruj me ntsis txwv tsis pub.

Txoj kev kho yuav tsum nrog cov suab thaj tswj. Ntawm cov kev mob tshwm sim, xeev siab, ntuav, raws plab, thiab mob hauv plab tuaj yeem pom. Muaj qee zaus, muaj ntshav txhaws thiab mob leukopenia. Nrog rau kev fab tshuaj rau qee yam tshuaj kho mob, cov pob yuav tawm pob. Gliclazide mv muaj ib tug xov tooj ntawm cov tshuaj uas tsis muaj qhov sib xws tau. Cov no yog cov tshuaj diuretics, barbiturates, estrogens, aminophylline tshuaj. Muaj tseeb, cov lus qhia rau kev siv yuav tsum tau kawm ua ntej pib kev kho mob nrog Glyclazide mv ntsiav tshuaj. Tus nqi ntawm cov khoom tsis tshaj 500 rubles.

Tshuaj qhov ncauj hypoglycemic. Cov ntsiav tshuaj dawb, me ntsis convex. Ntawm ob sab muaj cov cim ntawm DIA 60. Qhov no qhia tau tias cov tshuaj muaj ntawv tso cai. Nov yog ib qho qauv zoo rau cov tshuaj cuav.

Cov tshuaj hauv cov tshuaj suav nrog cov tshuaj gliclazide. Cov tshuaj tsuas yog kho rau cov laus xwb. Koj yuav tsum haus ib ntsiav tshuaj ib hnub ib zaug. Qhov no ua tau zoo tshaj thaum noj tshais. Ua raws li cov mob ntshav qab zib thiab cov kis mob uas dav dav, kev noj ntxiv tuaj yeem nce ntxiv rau ob ntsiav tshuaj ib hnub. Cov ntsiav tshuaj Glyclazide muaj cov kev noj tshuaj zoo tib yam. Cov lus qhia rau kev siv piav qhia txhua yam hauv kev nthuav dav.

Thaum siv tshuaj ntau ntawm cov tshuaj, hypoglycemia yuav tshwm sim. Hauv cov mob no, nws yog maj nrawm kom nrhiav kev pab los ntawm cov kws tshaj lij. Nws muaj tag nrho tib yam contraindications thiab kev phiv ua tshuaj "Gliclazide mv". Cov lus qhia rau kev siv, nqe, tshuaj xyuas - txhua yam no yuav tsum tau kawm ua ntej pib kev kho mob.

Xyuas cov tshuaj "Gliclazide"

Feem ntau, koj tuaj yeem hnov cov lus hais txog kev siv tshuaj zoo. Cov neeg mob nco ntsoov tias cov tshuaj no pab tswj cov ntshav qab zib thiab ua rau muaj kev noj qab haus huv ib txwm muaj. Qhov tsis yooj yim tsuas yog tias cov tshuaj yuav tsum tau coj nruj raws li txoj kev. Ib qho kev tshaj tawm tuaj yeem ua rau txaus ntshai heev.

Tus nqi ntawm Gliclazide hauv cov chaw muag tshuaj

Kev sau npe ntawm cov tshuaj tau tas sij hawm, yog li cov nqi ntawm Gliclazide tsis paub meej. Kwv yees tus nqi ntawm ib co analogues:

Gliclazide MV - 115–144 rubles. rau ib pob ntawm 60 ntsiav tshuaj ntawm 30 mg rau txhua,
Glidiab - 107-151 rubles. rau ib pob ntawm 60 ntsiav tshuaj ntawm 80 mg txhua,
Diabeton MV - 260–347 rubles. rau ib pob ntawm 30 ntsiav tshuaj ntawm 60 mg.