Siofor yog dab tsi los ntawm thiab hom tshuaj dab tsi yog qhov no: mechanism ntawm kev txiav txim, daim ntawv ntawm kev tso tawm thiab ntau npaum li cas

Daim ntawv noj tshuaj - dawb cov ntsiav tshuaj dawb:

• Siofor 500: puag ncig, biconvex (10 pcs. Hauv cov hlwv, hauv daim duab qhwv ib pob ntawm 3, 6 lossis 12 hlwv),
• Siofor 850: oblong, nrog kev sib tw ob sab (15 pcs. Hauv cov hlwv, hauv daim duab los qhia 2, 4 lossis 8 hlwv),
• Siofor 1000: oblong, nrog ib qho kev sib tw ntawm ib sab thiab lub ntsej muag zoo li tus "snap-tab" qhov qws tawm ntawm lwm qhov (15 pcs. Hauv cov hlwv, hauv pob ntawv qhwv ntawm 2, 4 lossis 8 blisters).

Cov tshuaj ua haujlwm nquag ntawm cov tshuaj yog metformin hydrochloride, hauv ib ntsiav tshuaj nws muaj 500 mg (Siofor 500), 850 mg (Siofor 850) lossis 1000 mg (Siofor 1000).

• Cov muaj mob: povidone, hypromellose, magnesium stearate,
• Lub plhaub muaj pes tsawg leeg: macrogol 6000, hypromellose, titanium dioxide (E171).

Kev ntsuas rau siv

Siofor yog npaj rau kev kho mob ntawm hom II mob ntshav qab zib mellitus, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob nyhav dhau los ua tsis tau tawm dag zog thiab kev tawm dag zog.

Nws tuaj yeem raug siv los ua yeeb tshuaj ib leeg lossis ib feem ntawm cov kev kho mob nyuaj hauv kev sib xyaw ua ke nrog insulin thiab lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yuav tsum tau noj nyob rau hauv lub qhov ncauj thaum noj mov lossis tam sim ntawd.

Qhov ntau npaum li cas thiab qhov ntev npaum li cas ntawm kev kho mob yog txiav txim siab los ntawm tus kws kho mob nyob ntawm seb nws nyob hauv qib cov piam thaj hauv ntshav.

Thaum ua cov kev kho mob monotherapy, cov neeg laus raug xaj 500 mg 1-2 zaug hauv ib hnub lossis 850 mg 1 zaug hauv ib hnub. Tom qab 10-15 hnub, yog tias tsim nyog, cov tshuaj txhua hnub yog maj mam nce mus rau 3-4 ntsiav tshuaj Siofor 500, 2-3 ntsiav tshuaj Siofor 850 mg lossis 2 ntsiav tshuaj Siofor 1000.

Qhov tshuaj tiv thaiv ntau tshaj plaws txhua hnub yog 3000 mg (6 ntsiav tshuaj 500 mg lossis 3 ntsiav tshuaj ntawm 1000 mg) hauv 3 koob tshuaj.

Thaum sau daim ntawv noj tshuaj kom siab, 2 ntsiav tshuaj ntawm Siofor 500 tuaj yeem hloov nrog 1 ntsiav tshuaj ntawm Siofor 1000.

Yog tias tus neeg mob hloov mus rau metformin los ntawm lwm cov tshuaj tiv thaiv kab mob siab, tom kawg tau tso tseg thiab lawv pib noj Siofor hauv kev noj tshuaj saum toj no.

Ua ke nrog cov tshuaj insulin (los txhim kho glycemic tswj), Siofor tau kho 500 mg 1-2 zaug ib hnub lossis 850 mg ib hnub ib zaug. Yog tias tsim nyog, ib hlis ib zaug koob tshuaj yog maj mam nce mus rau 3-4 ntsiav tshuaj Siofor 500, 2-3 ntsiav tshuaj Siofor 850 lossis 2 ntsiav tshuaj Siofor 1000. Cov koob tshuaj insulin raug txiav txim siab nyob ntawm theem ntawm cov piam thaj hauv cov ntshav. Qhov tshuaj tiv thaiv ntau tshaj plaws txhua hnub yog 3000 mg hauv 3 koob faib.

Thaum xaiv cov tshuaj, cov neeg laus cov neeg laus kuj coj mus rau hauv tus lej ntawm lub siab ntawm creatinine hauv ntshav ntshav. Thaum kho, kev ntsuam xyuas lub raum kev ua haujlwm yog qhov tsim nyog.

Cov menyuam hnub nyoog 10-18 xyoo thiab rau kev kho mob hlwb, thiab sib xyaw nrog cov tshuaj insulin, thaum pib kho mob 500 mg lossis 850 mg ntawm metformin 1 zaug hauv ib hnub. Yog tias tsim nyog, tom qab 10-15 hnub, qhov koob tshuaj yog maj mam nce. Qhov tshuaj ntau tshaj txhua hnub yog 2000 mg (4 ntsiav tshuaj ntawm 500 mg lossis 2 ntsiav tshuaj ntawm 1000 mg) hauv 2-3 koob.

Qhov yuav tsum tau txhaj ntawm cov tshuaj insulin yog txiav txim siab nyob ntawm seb cov piam thaj hauv cov ntshav yuav nce mus txog li cas.

Sab sij huam

• Ua xua: tsis tshua muaj - urticaria, khaus, hyperemia,
• Tej leeg hauv siab: ntau - saj yam ntxhov,
• Kev mob siab thiab mob hauv plab: cais cov ntawv qhia - qhov hloov pauv tau ntau ntxiv hauv kev ua haujlwm ntawm hepatic transaminases, kab mob siab (dhau los tom qab tshem tawm tshuaj),
• Kev tiv thaiv kab mob: tsis tshua muaj - lactic acidosis, nrog rau siv ntev - txo qis hauv qhov nqus ntawm cov vitamin B₁₂ thiab qhov kev txo qis hauv nws cov kev mob siab hauv cov ntshav ntshav (qhov tshwm sim ntawm qhov tshuaj tiv thaiv no yuav tsum raug coj los txiav txim thaum sau tshuaj rau cov neeg mob megaloblastic anemia),
• Lub plab zom mov: tsis muaj qab los noj mov, nws yog xim hlau saj ntawm lub qhov ncauj, xeev siab, ntuav, mob plab, raws plab. Cov tsos mob no feem ntau tshwm sim thaum pib kho thiab feem ntau nws tus kheej ploj mus. Txhawm rau tiv thaiv lawv, koj yuav tsum maj mam nce lub koob tshuaj txhua hnub, faib nws rau 2-3 koob tshuaj, thiab noj cov tshuaj nrog zaub mov lossis tam sim ntawd.

Cov lus qhia tshwj xeeb

Siofor tsis hloov cov khoom noj khoom noj kom zoo nkauj thiab tawm dag zog txhua hnub - cov kev siv tshuaj tsis siv tshuaj ntawm kev kho yuav tsum muab sib xyaw nrog cov tshuaj raws li cov lus pom zoo ntawm tus kws kho mob tuaj koom. Txhua tus neeg mob yuav tsum tau noj zaubmov kom muaj kev noj haus kom txaus rau txhua hnub, thiab cov neeg rog dhau mus yuav tsum noj zaub mov kom tsawg.

Yog tias koj xav tias qhov kev txhim kho ntawm cov kab mob lactic acidosis, yuav tsum tshem tawm sai sai ntawm cov tshuaj thiab cov neeg mob pw hauv tsev kho mob ceev.

Metformin raug ntuav tawm los ntawm lub raum, yog li ua ntej pib kev kho mob thiab tsis tu ncua nyob rau hauv nws cov txheej txheem, cov concentration ntawm creatinine hauv cov ntshav ntshav yuav tsum txiav txim siab. Kev tshuaj xyuas tshwj xeeb yog tsim nyog yog tias muaj kev pheej hmoo ntawm lub raum lub raum kev ua haujlwm, piv txwv li, thaum pib siv cov diuretics, tsis-tshuaj steroidal anti-inflammatory lossis antihypertensive tshuaj.

Yog tias nws yuav tsum tau soj ntsuam kev xoo hluav taws xob nrog kev tswj hwm kev tso tshuaj ntawm iodine-muaj cov tshuaj tiv thaiv tus neeg sawv cev, Siofor ib ntus (48 teev ua ntej thiab 48 teev tom qab cov txheej txheem) yuav tsum tau hloov nrog lwm cov tshuaj hypoglycemic. Qhov no yuav tsum tau ua ib yam li thaum sau tshuaj lub sijhawm ua haujlwm npaj phais raws li kev ua kom loog, nrog tshuaj pleev tshuaj rau pob txha los yog txha caj qaum.

Raws li kev tswj xyuas kab mob hauv ib xyoos, metformin tsis cuam tshuam rau kev loj hlob, kev loj hlob, thiab kev muaj menyuam yaus. Txawm li cas los xij, tsis muaj cov ntaub ntawv ntawm cov ntsuas no nrog kev kho mob ntev dua, yog li, cov menyuam tau txais Siofor, tshwj xeeb tshaj yog nyob rau lub sijhawm prepubertal (10-12 xyoo), xav tau kev soj ntsuam tshwj xeeb.

Kev kho mob Monotherapy nrog Siofor tsis ua rau lub ntsej muag ntshav qab zib. Nrog rau kev kho ua ke (hauv kev sib xyaw nrog insulin lossis sulfonylurea derivatives) muaj qhov xwm txheej zoo li no, yog li ntawd, yuav tsum ceev faj.

Siofor, siv ua ib qho tshuaj, tsis cuam tshuam loj heev rau qhov ceev ceev ntawm cov tshuaj tiv thaiv thiab / lossis muaj peev xwm mloog zoo. Thaum siv metformin ua ib feem ntawm kev kho mob nyuaj, muaj kev pheej hmoo ntawm kev txhim kho hypoglycemic, yog li, ceev faj yuav tsum ua thaum ua cov haujlwm muaj feem phom sij, suav nrog thaum tsav tsheb.

Yeeb tshuaj sib cuam tshuam

Metformin yog contraindicated thaum kawm nrog intravascular thawj coj ntawm iodine-muaj ib cov tshuaj tiv thaiv kab mob.

Nws tsis pom zoo siv dej cawv thiab noj tshuaj cawv nrog tshuaj thaum muaj kev kho mob, txij li kev pheej hmoo ntawm kev tsim cov kab mob lactic acid nce ntxiv, tshwj xeeb tshaj yog muaj daim siab tsis ua haujlwm, ua kom tsis zoo los yog kev noj haus.

Kev sib txuas ua ke xav tau ceev faj nyob rau hauv kev sib txuas nrog cov kev hloov pauv tau:

• Danazole - kev txhim kho ntawm cov nyhuv hyperglycemic,
• Angiotensin-hloov enzyme inhibitors thiab lwm cov tshuaj tiv thaiv kabmob ntshav - txo cov ntshav qabzib,
• Cov thyroid hormones, qhov ncauj tawm tsam, nicotinic acid, glucagon, epinephrine, phenothiazine derivatives - kev nce ntxiv hauv cov ntshav qabzib,
• Nifedipine - nce ntxiv thiab qhov siab tshaj plaws ntawm metformin nyob rau hauv cov ntshav ntshav, lub sijhawm ntev ntawm nws cov kev nthuav dav,
• Cimetidine - maj mam txiav tawm cov metformin, ua rau muaj kev pheej hmoo ntawm lactic acidosis,
• Salicylates, sulfonylurea derivatives, insulin, acarbose - muaj zog hypoglycemic,
• Cov tshuaj Cationic (procainamide, morphine, quinidine, triamteren, ranitidine, vancomycin, amiloride) zais cia rau hauv cov tubules - ib qho kev nce siab tshaj plaws ntawm metformin hauv ntshav ntshav,
• Furosemide - txo qis hauv nws qhov kev xav thiab ib nrab-lub neej,
• Indirect anticoagulants - ua rau lawv txoj haujlwm qaug zog,
• Beta-adrenergic agonists, diuretics, glucocorticoids (rau kev siv tshuaj thiab siv tshuaj pleev) - kev ua kom ntshav qabzib ntau ntxiv.