Kev siv ntawm cov tshuaj Blocktran, nws cov txiaj ntsig thiab kev pom zoo
Daim ntawv tshuaj ntawm Blocktran yog 12,5 mg ntsiav tshuaj (zaj duab xis-txheej) thiab 50 mg (zaj duab xis-coated) (10 pcs. Hauv cov hlwv, hauv ib pob ntawv los ntawm daim ntawv 1, 2, 3, 5, lossis 6 pob).
Cov khoom siv nquag: losartan potassium, hauv 1 ntsiav tshuaj - 12.5 lossis 50 mg.
Ntu cov khoom siv: sodium carboxymethyl hmoov txhuv nplej siab (sodium starch glycolate), microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide (aerosil), povidone (polyvinylpyrrolidone, povidone K17), cov hmoov txhuv nplej siab, magnesium stearate.
Lub plhaub muaj pes tsawg leeg: titanium dioxide (E171), copovidone, polysorbate 80 (kaum yim 80), talc, hypromellose (hydroxypropyl methylcellulose), zas xim.
Daim ntawv tso tawm
- Paj yeeb-txiv kab ntxwv biconvex round ntsiav tshuaj. 10 ntsiav tshuaj nyob rau hauv ib pob contour, 1, 3, 2, 5 lossis 6 pob khoom rau hauv ib lub thawv ntawv tuab.
- Liab biconvex ntsiav tshuaj ntawm ib puag ncig daim ntawv, ntawm so - cov xim dawb. 10 ntsiav tshuaj nyob rau hauv ib pob contour, 1, 3, 2, 5 lossis 6 pob khoom rau hauv ib lub thawv ntawv tuab.
Cov chaw muag tshuaj ntawm losartan
Angiotensin ntawm hom thib ob yog muaj zog vasoconstrictor, tus neeg sib kho tseem ceeb renin-angiotensin system thiab cov ntawv tseem ceeb pathophysiological txuas leeg ntshav siab. Losartan Receptor blocker angiotensin2 hom. Angiotensin xaiv txoj hlua khi rau AT1-hom receptorsnyob rau hauv lub qog adrenal, nyob rau hauv cov ntaub so ntswg ntawm cov hlab ntshav, hauv lub raum thiab lub plawv thiab txhawb kev vasoconstriction thiab ntau lawm aldosteroneyog tseem tuaj yeem ua rau kev loj hlob ntawm cov nqaij leeg. Qhov no cov khoom thiab nws kom nquag plias metabolite thaiv tag nrho cov cuam tshuam angiotensin 2 hom tsis hais lub qhov los yog hom kev ua ke.
Losartan tsis thaiv tus so ntawm cov receptors cov tshuaj hormones lossis ion channels uas tswj cov kab mob plawv. Tsis suppress angiotensin hloov ua enzymelub luag hauj lwm rau inactivation bradykininua rau cov kev mob tshwm sim nrog bradykinin muaj tsawg heev. Thaum siv losartan muaj kev ua kom ntshav ntau ntxiv renin, uas nyob rau hauv lem txhawb kev nce ntxiv hauv cov ntsiab lus ntawm hom 2 angiotensin nyob rau hauv ntshavCov. Kev tiv thaiv kev ua ub ua no thiab txo qis qis aldosteronecov ntshav raug khaws cia, uas qhia txog qhov thaiv tau zoo angiotensin receptors.
Losartan thiab nws cov khoom noj hluav taws xob tseem ceeb muaj tropism rau cov txais angiotensin 1 yam loj dua li cov receptors angiotensin 2 hom. Cov kev teeb tsa tshwj xeeb tshaj yog siv tau ntau dua losartan 10-40 zaug. Tom qab kev tswj hwm, qhov kev txiav txim ncav nws lub zog siab tshaj plaws tom qab rau teev, thiab tom qab ntawd maj mam poob qis dua ntawm 24 teev. Qhov zoo tshaj plaws antihypertensive nyhuv yog kaw tom qab 4-6 lub lis piam los ntawm kev pib kho tshuaj. Cov nyhuv no nce nrog ntau zuj zus. losartan.
Losartan tsis cuam tshuam rau vegetative reflexes thiab tsis hloov lub siab norepinephrine hauv cov ntshav ntev.
Hauv cov neeg mob mob nrog sab laug ventricle thiab leeg ntshav siablosartan, suav nrog hauv nrog hydrochlorothiazide, txo qhov ntxim nyiam ntawm cov hlab plawv tuag thiab cov mob.
Cov chaw muag tshuaj ntawm hydrochlorothiazide
Mechanism ntawm kev ua thiazide-diuretics tsis paub. Lawv feem ntau tsis cuam tshuam qhov qub.
Hydrochlorothiazide yog ob qho tib si antihypertensive siv yeeb siv tshuaj, thiab tshuaj kho mobCov. Nws cuam tshuam qhov thim rov qab nqus ntawm electrolytes hauv cov menyuam ntawm ob lub raum. Kwv yees li qhov qub nce ion excretion tshuaj yoos thiab sodium. Natriurez nrog kev poob zoo bicarbonateions poov tshuaj thiab kev ncua sijhawm calciumCov. Lub diuretic nyhuv tau sau cia 2 teev tom qab kev tswj hwm, nce mus txog qhov siab kawg tom qab 4 teev thiab kav ntev txog 7-12 teev.
Leej twg raug tsa
Hauv cov lus qhia, kev taw qhia rau kev siv Blocktran raug txwv tsuas yog ob lub ntsiab lus:
- Nrog kub siab, kev teem sij hawm tshuaj tso cai rau koj kom ua tiav qhov txo qis hauv kev siab. Blocktran rau qhov ntsuas no yuav tau haus dej haus txhua hnub ntev.
- Hauv lub plawv tsis ua hauj lwm, ib qho tshuaj siab siab tau raug muab tshuaj kho hloov pauv rau ACE inhibitors (antihypertensive ntsiav tshuaj nrog rau qhov xaus - adj) yog tias lawv ua rau muaj kev mob tshwm sim.
Kev sib piv ntawm cov txiaj ntsig ntawm Blocktran thiab nws cov analogues nrog cov tshuaj kho mob siab rau lwm cov chaw muag tshuaj qhia tau hais tias cov tshuaj no ze rau qhov kev nqis tes ua: lawv muab kwv yees li qub kev txo lub siab, muaj kev tiv thaiv sib luag los ntawm kev kub siab thiab lawv cov kev phom sij.
Blocktran thiab lwm yam tshuaj nrog losartan muaj ntau qhov sib txawv tseem ceeb los ntawm lwm cov tshuaj tiv thaiv antihypertensive. Nws yog cov kev sib txawv no uas txiav txim siab lawv qhov kev siv ntawm kev siv.
Dab tsi pab Blocktran:
- ntsiav tshuaj muaj lub txiaj ntsig. Rau kev txhim kho ntawm qhov siab tshaj plaws, ib hnub kom tsawg yog xav tau 2-5 lub lis piam.
- lub siab txo ua tiav nrog Blocktran tau ruaj khov. Tau siv tshuaj thiab txo nws cov txiaj ntsig nrog kev kho mob ntev ntev tshwm sim ntau zaus tsawg dua nrog beta-blockers lossis ACE inhibitors,
- lub zog ntawm Blocktran qhov kev txiav txim tsis cuam tshuam nrog haiv neeg, poj niam txiv neej, hnub nyoog ntawm tus neeg mob,
- txhua tus sartans, suav nrog Blocktran, muaj kev tiv thaiv zoo. Cov tshuaj no yog qhov zoo tshaj plaws ntawm txhua cov tshuaj tiv thaiv kabmob, qhov ntau zaus ntawm lawv cov kev mob tshwm sim yog qhov tsawg. Piv nrog ACE inhibitors, nws yog qhov tsawg dua rau kev hnoos, hyperkalemia, kev txhaum fab hnyav,
- Tau ntev, Blocktran tau xav tau qhov nruab nrab los ntawm lub cev. Tam sim no nws paub tias nws pab txhawm rau txo cov tshuaj tiv thaiv insulin thiab cov cholesterol, yog li nws tuaj yeem siv dav los tswj ntshav siab hauv ntshav qab zib mellitus,
- cov tshuaj tsis cuam tshuam rau bronchial patency (tsis ua rau hnoos) thiab erectile muaj nuj nqi,
- sartans yog qhov sib tw tseem ceeb ntawm ACE inhibitors hauv lub plawv tsis ua haujlwm. Muaj cov pov thawj uas losartan muab tib lub neej zoo, txo qis kev pheej hmoo ntawm lub plawv thiab mob hlab ntsha tawg, txhim kho kev mob ntawm cov neeg mob nephropathy, myocardial hypertrophy, ntxiv rau ACE inhibitors.
- nrog nephropathy, kev siv Blocktran mus sij hawm ntev tuaj yeem txo cov proteinuria los ntawm 35%, txo qhov kev pheej hmoo ntawm lub raum tsis ua hauj lwm los ntawm qhov kawg, qhov xaus, theem ntawm 28%,
- losartan muaj cov nyhuv antiarrhythmic,
- cov tshuaj muaj cov txiaj ntsig zoo ntawm purine metabolism: nws txhawb nqa kev nthuav dav ntawm uric acid, txhim kho cov mob ntawm cov neeg mob gout.
Yog li, kev siv Blocktran hauv kev kho mob hauv tsev kho mob muaj ntau dav dua li piav hauv cov lus qhia.
Cov tshuaj ua haujlwm li cas?
Tus txheej txheem ntawm kev ua ntawm losartan yog los thaiv cov receptors rau angiotensin hom II AT-1. Angiotensin II yog ib qho tseem ceeb peptides koom nrog hauv kev kaw lus ntawm kev tswj siab hauv lub cev. Nws muaj qhov cuam tshuam ncaj qha rau ntawm cov qib siab: nws txwv cov hlab ntshav, nce lawv qhov kev tawm tsam, txhawb kev tsim cov aldosterone (qhov tshuaj lub luag haujlwm rau cov dej-ntsev sib npaug), thiab txo cov zis.
Cov tshuaj blocktran ua xaiv yam: lawv thaiv tsuas yog cov neeg mob angiotensin uas cuam tshuam rau yam uas ua rau tawg. Raws li qhov tshwm sim ntawm cov thaiv xws li, lub suab vascular txo qis, siab poob tawm.
Ntawm dab tsi siab yuav tsum Blocktran noj: hypertension yog kuaj sai li sai tau ntawm qhov nruab nrab txhua hnub siab txog qib nce mus txog 140/90. Thaum xub thawj, feem ntau mob sib khuav, sib kis mob, cov neeg mob raug nquahu kom yuag, kev ua kom lub cev thiab kev noj haus zoo. Yog tias cov kev ntsuas no ua tsis tau zoo, sau ntawv kom tswj lub siab. Thaum xaiv cov tshuaj tshwj xeeb, lawv feem ntau tsom rau nws cov yam ntxwv ntxiv. Piv txwv, diuretics yog qhia rau lub plawv tsis ua hauj lwm, calcium antagonists - tom qab mob hlab ntsha tawg. Qhov chaw ntawm sartans nyob rau hauv cov hierarchy no yog kev tiv thaiv ntawm cov hlab plawv ischemia. Lawv feem ntau hloov los ntawm ACE inhibitors yog tias lawv ua rau muaj kev mob tshwm sim. Raws li cov neeg mob, losartan yog qhov muab tshuaj thawj lub tshuaj yuav luag tsis tshua muaj.
Pharmacological cov yam ntxwv ntawm Blocktran ntsiav tshuaj:
Theem Qib Theem | koob tshuaj ib zaug | Raws li cov lus qhia rau kev siv, qhov ua tiav siab tshaj plaws tau tiav tom qab 6 teev, lub sijhawm ua haujlwm tsis tsawg dua ib hnub. |
niaj hnub txais | Nrog rau qhov siv ntev, qhov ua tau zoo zuj zus mus, nce mus txog qhov siab kawg los ntawm qhov kawg ntawm thawj lub hlis thiab tseem nyob rau theem siab txhua lub sijhawm ntawm kev kho mob. | |
Pharmacological kev ua si | Losartan yog yuav luag devoid ntawm pharmacological kev ua si, vim hais tias yog ib tug prodrug. Cov kab mob siab losartan, cov tshuaj tsim los ntawm nws qhov kev hloov pauv hauv daim siab, muaj qhov ua kom muaj zog thiab ntev ntev hypotensive. | |
Cov theem ntawm cov khoom muaj sia hauv cov ntshav | siab tshaj plaws | Losartan - 1 teev, nquag metabolites - txog 4 teev. |
ib nrab-lub neej | Losartan - txog 2 teev, metabolites - txog 9 teev. | |
Kev cais tawm | 35% yog ob lub raum, 60% yog lub plab zom mov. |
Tsis zoo li ACE inhibitors, Blocktran tsis ua rau hypotension thaum pib kho. Thaum cov ntsiav tshuaj tso tseg, lub siab maj mam nce mus rau qib dhau los, ib qho kev dhia ntse tsis tshwm sim.
Cov Yuav Tsum Muaj
arterial siab hypotension,
- Kev tsis zoo hauv lub raum (creatinine tshem tawm tsawg dua 30 ml / min),
- tib lub sij hawm siv nrog npaj poov tshuaj, potassium-sparing diuretics,
- mob siab ua rau daim siab mob siab dua (ntau dua li 9 ntsiab lus ntawm Cov Menyuam Me-Pugh nplai), cholestasis,
- cev xeeb tub thiab lub sijhawm pub mis niam,
- lub hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv tsis tau tsim),
- Cov tshuaj tiv thaiv tsis haum rau cov tshuaj, lwm yam tshuaj sulfonylamide,
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.
Yuav noj li cas
Qhov ua tau zoo ntawm kev kho mob nrog Blocktran ntsiav tshuaj lom zem ntau nyob ntawm txoj kev noj tshuaj thiab kev ua kom raws li txoj cai ntawm kev pub nkag mus. Cov neeg mob uas tau muab tshuaj rau feem ntau muaj cov lus nug uas tsis nkag siab lossis tsis txaus ntseeg nyob rau hauv cov lus qhia rau kev siv. Cia peb nyob nrog lawv hauv kev nthuav dav ntxiv.
Yuav xaiv cov koob tshuaj zoo npaum li cas?
Kev kho mob ntawm kub siab yuav pib nrog 50 mg. Yog tias tus neeg mob noj cov tshuaj diuretics - los ntawm 25 mg, nrog lub plawv tsis ua hauj lwm - los ntawm 12,5 mg. Cov koob tshuaj no yog qaug cawv 1 lub lim tiam, ua tib zoo saib xyuas lawv tus mob thiab qib siab. Yog tias lub siab tsis tau poob rau lub hom phiaj qib (txij li 125/75 txog 140/90, tus kws kho mob txiav txim siab), thiab cov tshuaj tsis ua rau muaj kev phiv, qhov koob tshuaj yog maj mam nce. Txij thaum pib ntawm lub lim tiam tshiab, 12,5 mg tau ntxiv thiab pom ntxiv. Hauv ntau theem, qhov koob tshuaj muaj peev xwm nce ntxiv mus txog qhov siab tshaj 100 mg. Yog tias nws tsis muab rau qib hom phiaj siab, qhov kev qhia pom zoo kom hloov Blocktran nrog Blocktran GT.
Koj puas xav tau blocktran ua ntej noj mov lossis tom qab?
Txij li pom los ntawm cov txiaj ntsig ntawm kev kho mob, lub sijhawm ntawm kev tswj hwm tsis txawv, txij li cov zaub mov tsis cuam tshuam rau qib ntawm kev nqus ntawm losartan. Txawm li cas los xij, ntau cov tshuaj muaj lub siab zoo dua yog tias koj haus lawv tom qab noj mov.
Nws puas zoo dua rau haus cov tshuaj thaum sawv ntxov lossis yav tsaus ntuj? Cov lus qhia rau kev siv Blocktran tsis qhia lub sijhawm sijhawm siab tshaj plaws rau nws tau txais nws. Txij li thaum cov nyhuv ntawm cov tshuaj tsis sib xws (ntau 6 teev tom qab tswj hwm), nws cov nyhuv hypotensive tuaj yeem tswj tau. Piv txwv, yog tias qhov siab nce siab thaum nruab hnub, nws yog qhov muaj txiaj ntsig ntau dua rau haus tshuaj ntsiav thaum sawv ntxov, yog tias thaum ntxov - ua ntej yuav mus pw.
Koj tau txhaj pes tsawg koob tshuaj hno cov tshuaj txhua hnub?
Rau feem ntau cov neeg mob, ib qho tshuaj noj xwb zoo dua. Yog tias cov koob tshuaj ntau tshaj 50 mg, nws tuaj yeem faib ua 2 zaug.
Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva
Kuv tau kawm qhov teeb meem mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.
Kuv maj nrawm los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov mob ntshav qab zib mellitus kom zoo. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.
Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib kom txog thaum lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!
Cov tshuaj siab twg Kuv tuaj yeem haus Blocktran? Kev sib xyaw ua ke zoo tshaj rau losartan yog calcium antagonists thiab diuretics, qhov sib txuam ua tau yog losartan thiab beta-blockers. Blocktran muaj cov lus qhia tsis sib haum rau kev sib koom tes nrog cov tshuaj uas muaj qhov ua haujlwm zoo sib xws: lwm yam sartans, ACE inhibitors. Kev siv ua ke nrog cov tshuaj potassium-sparing diuretics (Veroshpiron) yuav tsum muaj kev tswj hwm ntxiv vim tias qhov pheej hmoo ntawm hyperkalemia.
Yuav siv li cas: noj ntau thiab hom tshuaj kho
Txais ntawm qhov ncauj, tsis hais txog kev noj me me, npaum li cas los txais Blocktran GT - 1 zaug nyob rau ib hnub.
Qhov pib thiab kev saib xyuas qhov koob tshuaj yog 1 ntsiav tshuaj 1 zaug nyob rau ib hnub. Hauv 13 qhov teeb meem cais, txhawm kom ua kom tau txais txiaj ntsig ntau dua, cov koob tshuaj tau nce rau 2 ntsiav tshuaj 1 zaug hauv ib hnub. Qhov siab tshaj plaws niaj hnub noj yog 2 ntsiav tshuaj ntawm Blocktran GT.
Nws tsis tas yuav kho qhov koob tshuaj rau cov neeg laus thiab cov neeg mob lub raum tsis ua haujlwm (CC 30-50 ml / min).
Txo txoj kev pheej hmoo ntawm cov kab mob plawv thiab kev tuag ntawm cov neeg mob ntshav liab thiab sab laug ventricular hypertrophy
Pharmacological kev txiav txim
Lub Cheebtsam ntawm Blocktran GT muaj cov txiaj ntsig ntawm qhov tawm tsam, txo cov ntshav siab (BP) kom ntau dua li ntawm txhua qhov ntawm cov feem. Vim yog cov nyhuv diuretic, hydrochlorothiazide tsub kom ntshav plasma renin kev ua si (ARP), txhawb kev zais ntshis ntawm aldosterone, nce qhov nce ntawm aigiotensin II thiab txo cov ntsiab lus poov tshuaj potassium. Tau txais losartan thaiv tag nrho cov kev mob physiological ntawm aigiotensin II thiab, vim yog kev tsuj tawm ntawm cov teebmeem ntawm aldosterone, tuaj yeem pab txo kom tsis txhob muaj cov potassium ntxiv nrog rau kev noj tshuaj diuretic.
Hydrochlorogiazide ua rau muaj qhov nce me ntsis hauv kev ua haujlwm ntawm uric acid nyob rau hauv cov ntshav ntshav, losartan muaj cov txiaj ntsig nruab nrab thiab hloov mus rau uricosuric. Kev sib xyaw ua ke ntawm losartan thiab hydrochlorothiazide pab txo cov leeg mob hyperuricemia los ntawm diuretic.
Losartan: Angiotensin II yog vasoconstrictor muaj zog, qhov kev loj hlob tseem ceeb ntawm renin-angiotensin-aldosterone system, thiab tseem yog ib qho tseem ceeb pathophysiological txuas hauv kev txhim kho cov hlab ntsha txhaws. Losartan yog tus neeg tawm tsam ntawm aigiotensin II receptors (hom AT1). Angiotensin II xaiv zoo khi rau AT1 cov neeg tau txais pom hauv ntau cov ntaub so ntswg (hauv cov leeg nqaij ntshiab ntawm cov hlab ntsha, qog adrenal, raum thiab lub siab) thiab ua ntau txoj haujlwm tseem ceeb hauv kev ua haujlwm, suav nrog vasoconstriction thiab tso tawm aldosterone. Angiotensin II tseem muaj kev cuam tshuam cov kev loj hlob ntawm cov leeg hlwb muaj zog.
Sab sij huam
Hauv kev tshawb fawb soj ntsuam nrog losartan / hydrochlorothiazide, tsis muaj qhov xwm txheej tsis zoo rau cov tshuaj sib xyaw no tau pom. Cov xwm txheej tsis zoo tsuas yog siv rau cov uas tau hais ua ntej losartan thiab hydrochlorothiazide nkaus xwb.
Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: ua haujlwm sab hauv - ntshav liab, Shenlane-Genoch purpura, ecchymosis, hemolytic anemia.
Ua xua: tsis tshua muaj - muaj kev phiv tshuaj anaphylactic, angioedema, urticaria.
Ntawm ib feem ntawm cov metabolism thiab khoom noj khoom haus: tsis xws luag - tsis nco qab, exacerbation ntawm cov hoob kawm ntawm gout.
Los ntawm lub hauv nruab nrab hauv cov hlab ntsha hauv lub cev: feem ntau - mob taub hau, kiv taub hau, pw tsaug zog, ua tsis tsaug zog - ntxhov siab, mob plab, peripheral neuropathy, tshee, mob taub hau, tsaus muag, ntxhov siab, ntxhov siab ntxhov siab, ceeb ntshai, tsis meej pem, poob siab, tsaug zog, tsis meej xeeb Cov.
Los ntawm sab ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: ua ntu zus - qhov muag tsis pom kev, muaj qhov zoo li dryness thiab hlawv hauv lub qhov muag, pom pob txha, txo qhov muag pom.
Los ntawm sab ntawm lub rooj sib hais: xws li - ncab - vertigo, tinnitus.
Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: ua haujlwm sab hauv - agranulocytosis, mob ntshav tsis txaus, ntshav tsis txaus, mob qog ntshav, kab mob ntshav, ntshav txhaws, thuv ntshav.
Ua xua: tsis tshua muaj - muaj kev xav tshuaj.
Los ntawm ib sab ntawm cov metabolism thiab khoom noj khoom haus: ntxiag dhau - anorexia, hyperglycemia, hyperuricemia, hypokalemia, hyponatremia.
Los ntawm cov leeg hlwb: feem ntau - mob taub hau, tshwm sim - kiv taub hau, pw tsaug zog.
Los ntawm ob sab ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: ua ntu zus - cov tsis pom kev tsis pom kev ntev, xanthopsia.
Los ntawm cov hlab plawv system: ncaw - necrotizing vasculitis.
Cov lus qhia tshwj xeeb
Blocktran GT, zoo li qee cov tshuaj uas cuam tshuam rau renin-angiotensin-aldosterone system, tuaj yeem nce siab ntau ntawm cov ntshav urea thiab cov ntshav creatinine rau cov neeg mob uas muaj ob leeg lub raum artery stenosis lossis stenosis ntawm ib lub raum artery. Cov kev pauv hauv lub raum ua tau thim rov qab thiab ploj mus tom qab kev tsis ua tiav ntawm kev kho.
Nws tsis pom zoo tias cov tshuaj no tau sau tseg rau cov tsos mob nce ntxiv hauv cov concentration ntawm uric acid thiab rau gout.
Kev sib txuam
Yuav kom kho nrog lwm tus neeg sawv cev antihypertensive.
Nrog rau kev siv ua ke nrog barbiturates, narcotic analgesics, ethanol, orthostatic hypotheisia tuaj yeem txhim kho. Nrog rau kev siv ua ke nrog hypoglycemic tshuaj (rau kev tswj hwm ntawm qhov ncauj thiab cov tshuaj insulin), yuav tsum tau txhaj tshuaj kho cov tshuaj hypoglycemic nyob rau hauv lub sijhawm. Vim txoj kev pheej hmoo ntawm kev tsim cov kab mob lactic acidosis vim muaj kev cuam tshuam rau lub raum kev ua haujlwm, metformnn yuav tsum tau siv nrog ceeb toom thaum siv hydrochlorothornazide.
Nrog rau kev siv ua ke ntawm Blocktran GT nrog rau lwm cov tshuaj tiv thaiv kev kub ntxhov, ib qho kev tiv thaiv ntxiv tau pom.
Cov Tshuaj Pharmacokinetics
Thaum tswj hwm, losartan tau zoo los ntawm lub plab zom mov thiab metabolized hauv daim siab nrog rau kev koom nrog CYP2C9 isoenzyme, ua rau ib carboxylated active metabolite (kwv yees li 14% ntawm qhov lees txais tau nkag mus rau nws) thiab ntau qhov chaw tsis haum tshuaj. Nws qhov kev siv xyoob ntoo mus txog 33%. Qhov siab tshaj plaws ntawm losartan thiab nws lub ntsiab metabolite tau sau tseg tom qab 1 teev thiab 3-4 teev tom qab noj Blocktran, ntsig txog.
Qib qhov kev khi ntawm cov kev sib txuam ntawm Blocktran mus rau cov ntshav plasma protein (feem ntau albumin) yog kwv yees li 99%. Losartan kev siv tsis nkag rau cov ntshav-hlwb teeb meem.
Ib nrab-lub neej ntawm losartan yog 1.5-2 teev, thiab nws cov tshuaj pharmacologically nquag metabolite yog 6-9 teev. Kwv yees li ntawm 35% ntawm qhov koob tshuaj tau tawm los ntawm ob lub raum, thiab li 60% los ntawm txoj hnyuv.
Cov kev tshawb fawb soj ntsuam paub meej tias cov ntsiab lus ntawm losartan hauv cov ntshav ntshav hauv cov neeg mob ntshav siab yog qhov nce ntau, yog li, cov neeg mob uas muaj keeb kwm muaj kab mob siab yuav tsum tau txhaj tshuaj ntawm Blocktran qis dua.
Cov lus qhia rau kev siv Blocktran: txoj kev thiab qhov ntau npaum li cas
Blocktran yuav tsum noj qhov ncauj 1 zaug nyob rau ib hnub. Khoom noj tsis cuam tshuam rau kev nqus ntawm cov tshuaj.
Nrog kev mob ntshav siab, 50 mg rau ib hnub twg feem ntau yog kho. Qee qhov xwm txheej, nws muaj peev xwm nce ntxiv qhov koob tshuaj txhua hnub rau 100 mg hauv 1-2 koob tshuaj.
Hauv lub plawv tsis ua haujlwm, kev kho mob pib nrog kev siv tshuaj txhua hnub ntawm 12,5 mg. Tom qab ntawd, ib zaug ib lub lim tiam, cov koob tshuaj tau nce nyob ntawm cov duab saib mob: thawj zaug txog 25 mg, tom qab ntawd nce txog 50 mg.
Thawj koob tshuaj txhua hnub rau cov neeg mob lub plawv tsis ua hauj lwm tau txais kev txhaj tshuaj ntau ntawm diuretics yog 25 mg.
Nrog rau daim siab ua haujlwm, cov concentration ntawm losartan nyob rau hauv cov ntshav ntshav nce ntxiv, yog li ntawd, Blocktran siv rau hauv cov koob tshuaj qis dua.
Cov lus qhia rau siv Blocktran GT
Cov tshuaj yuav tsum tau noj qhov ncauj ib zaug ib hnub.
Ntawm leeg ntshav siab kev pib thiab saib xyuas qhov ntau npaum - 1 ntsiav tshuaj ib hnub ib zaug. Qee qhov xwm txheej, kom ua tiav qhov tshwm sim zoo dua, tsuas tshuaj yog ntxiv rau 2 ntsiav tshuaj ib hnub ib zaug. Qhov siab tshaj plaws txhua hnub yog 2 ntsiav tshuaj ntawm cov tshuaj.
Thaum siv los txo cov kev pheej hmoo kev mob plawv thiab kev tuag nyob hauv cov neeg nrog leeg ntshav siab thiab nce ntxiv hauv cov laug ventricle thawj koob losartan sib npaug txog 50 mg ib hnub ib zaug. Cov neeg mob nrog 50 mg losartan ib hnub twg qhov kev xav tau ntawm qhov siab tsis tuaj yeem mus txog, kev xaiv txoj kev kho los ntawm kev sib koom ua ke yog qhov yuav tsum tau ua losartantsawg kawg tshuaj hydrochlorothiazide (12,5 mg), thiab yog tias tsim nyog, ua rau kom cov tshuaj ntau dua losartantxog li 100 mg rau ib hnub twg nrog 12.5 mg hydrochlorothiazide ib hnub. Tom qab ntawd nws raug tso cai nce tshuaj ntau ntxiv rau 2 ntsiav tshuaj ntawm Blocktran GT ib hnub.
Noj ntau dhau
Yog tias muaj kev noj ntau dhau, kev siv tshuaj yuav tsum tsis ua haujlwm ntxiv, tus neeg mob yuav tsum tau txais kev tswj hwm lub plawv thiab lub ntsws ua haujlwm, kev kho mob - kev kho lub plab, tshem tawm cov roj ntsha cuam tshuam, lub cev qhuav dej. hepatic tsis meej pemthiab depressurization los ntawm cov qauv kev.
Muaj kev phiv ntau
Raws li kev tshawb fawb, ntawm cov ntsiav tshuaj antihypertensive, sartans yog tus cwj pwm los ntawm coplanation zoo dua. Qhov no txhais tau tias cov neeg mob coj lawv kev qhuab qhia ntau, tsawg dua yuav tsum tau txiav kev kho lawv tus kheej. Cov laj thawj rau qhov kev vam meej no yog qhov yooj yim ntawm kev tswj hwm (tsuas yog 1 sijhawm), kev xaiv qhov yooj yim ntawm kev xaiv koob tshuaj, tus lej tsawg ntawm cov kev mob tshwm sim.
Cov tshuaj tiv thaiv blocktran piv rau cov tshuaj placebo (tshuaj ntsiav ntsiag to). Feem ntau cov kev mob tshwm sim ntawm cov tshuaj tsis cuam tshuam nrog kev tsis zoo, tab sis nrog lub cev kev teb rau txo cov ntshav siab. Raws li txoj cai, hauv thawj lub hlis ntawm kev kho mob hypertensives xav tias zuj zus, hauv lub siab ntev ntev yog nyob ntawm qhov nce ntawm qib.
Cov kev phiv uas, thaum siv Blocktran, tshwm sim ntau dua li ntawm cov pab pawg:
Zaus% | Phiv Txheej Xwm |
ntau tshaj 1 | Kiv taub hau, qaug zog, pw tsaug zog ib ce, mob taub hau. |
Xeev siab | |
Mob nqaij, ua pob ntawm plab hlaub. | |
mus txog 1 | Kev qoj ib ce los sis goosebumps, tsis hnov rhiab, tsis nco qab zoo, tsis hnov qab, pw tsaug zog. |
Kev hnyav dua, teeb meem plab zom mov. | |
Mob tej pob txha. | |
Muaj zis ntau ntxiv, txo qis libido. | |
Qhuav ntawm daim tawv nqaij, hnoos qeev ua rau tawv nqaij, nce tawv nqaij cov tshuaj tiv thaiv rau ultraviolet hluav taws xob. | |
Kev ua xua tsis haum. |
Cov neeg mob siab dua rau lub raum pathologies, cov neeg laus laus, Blocktran ntsiav tshuaj muaj peev xwm zam tau zoo li lwm tus neeg mob. Nrog rau daim siab ua haujlwm thiab mob ntsws, muaj kev pheej hmoo ntawm kev noj ntau tshaj yog qhov siab vim qhov ua txhaum ntawm losartan metabolism. Nyob rau hauv rooj plaub ntawm overdose, hypotension, tachycardia, bradycardia yog ua tau.
Cov neeg mob lub cev qhuav dej, mob ntshav qab zib nrog nephropathy, cov neeg noj tshuaj Veroshpiron lossis potassium npaj muaj kev pheej hmoo siab mob ntshav siab. Tus mob no tuaj yeem ntseeg tsis meej cov leeg tsis muaj zog, mob hauv zos, mob plawv ib ce. Yog tias pom hyperkalemia (poov tshuaj> 5.5 raws li kev soj ntsuam), Blocktran tau muab tso tseg.
Kev sib piv thiab hloov chaw
Blocktran's cov khoom sib piv yog tsim los ntawm ntau cov kws lag luam tshuaj muaj txiaj ntsig. Kev txiav txim los ntawm kev tshuaj xyuas cov neeg mob ntshav siab, cov tshuaj hauv qab no yog qhov nrov tshaj plaws hauv tebchaws Russia:
Chaw tsim tshuaj paus | Blocktran Analog | Tus nqi yog 28-30 ntsiav tshuaj. (50 mg), txhuam. | Analog Blocktran GT | Tus nqi yog 28-30 ntsiav tshuaj. (50 + 12.5 mg), rub. |
Krka (Slovenia, Lavxias Federation) | Lorista | 195 | Lorista N | 275 |
Zentiva (Slovakia, Czech koom pheej) | Lozap | 270 | Lozap Ntxiv | 350 |
Actavis (Iceland) | Vasotens | 265 | Vasotens N | 305 |
Merck (Netherlands) | Cozaar | 215 | Gizaar | 425 |
Teva (Ixayees), Gideon Richter (Hungary), Atoll, Canonfarma (RF) | Losartan | 60-165 | Losartan n | 75-305 |
Sandoz, Lek (Slovenia) | Lozarel | 210 | Lozarel Ntxiv | 230 |
Ipka (Is Nrias teb) | Tubkawm Presartan | 135 | Presartan N | 200 |
Cov tshuaj blocktran nrog cov txiaj ntsig ze tshaj plaws yog valsartan (ntsiav tshuaj Valsacor, Diovan, thiab lwm yam), candesartan (Ordiss), telmisartan (Mikardis, Telzap).
Kev piav qhia thiab chaw muag tshuaj ntawm cov tshuaj
Siv cov khoom lag luam pab txo qis qhov kev tawm tsam ntawm cov hlab ntsha nqaj nqaj, txo qis qib ntawm kev mloog zoo ntawm aldosterone thiab angiotensin hauv cov ntshav. Cov tshuaj blocktran, cov lus qhia rau kev siv uas muaj cov ncauj lus qhia ntxaws txog cov tshuaj, yog kws kho mob kws kho plawv kom rov ua haujlwm plawv rau cov tib neeg nruab nrab thiab laus. Ib ntsiav tshuaj muaj tsawg kawg yog 50 mg ntawm losartan nrog rau cov khoom siv ntu, nrog rau lactose, hmoov txhuv nplej siab, magnesium stearate thiab ib tug lej ntawm lwm cov tshuaj yeeb dej caw.
Tseem Ceeb! Cov tshuaj Blocktran GT tau tsim nyob rau hauv kev txiav txim siab kom txo qis siab thiab coj nws rov qab los nyob rau hauv cov neeg mob kev txom nyem los ntawm ntau lub npe hu ua cov hlab plawv pathologies. Cov khoom siv ua ke - losartan thiab hydrochlorothiazide - muaj qhov cuam tshuam nyuaj.
Hauv kev coj ntawm cov tshuaj hauv cov neeg mob, ib qho kev txo qis hauv lub nra ntawm lub plawv mob yog sau tseg, uas tiv thaiv kev txhim kho hypertrophic myocardial kev puas tsuaj. Losartan tseem muab cov nyhuv diuretic thiab tsis inhibit AP enzyme uas rhuav tshem bradykinin. Vim qhov no, Blocktran tsis ua rau muaj kev txhim kho hnoos qhuav, zoo li lwm yam tshuaj ntawm tib pab pawg.
Lub suab nrov tshwm sim 6 teev tom qab kev tswj hwm, tom qab ntawd lub ntsiab lus siab poob thaum nruab hnub thiab tswj hwm tus nqi tsim nyog. Nrog kev siv tas li, cov tshuaj muaj cov nyhuv hypotensive tom qab ib hlis.
Plawv
Kev ua txoj kev ua
Raws li cov lus qhia rau kev siv, cov tshuaj tau sai heev los ntawm cov hnyuv zom zaub mov nrog kev siv nyiaj ntawm bioavailability tsawg kawg 30%. Qhov kev kub siab ntawm cov tshuaj nquag nce mus txog nws lub ncov ib teev tom qab kev tswj hwm. Cov khoom siv ntawm cov ntsiav tshuaj hauv cov qog hlwb raug hloov pauv mus rau hauv metabolites uas ua rau muaj kev cuam tshuam hypotensive. Lub metabolite yog ua rau siab nyob rau hauv cov ntshav tom qab 4 teev. Losartan raug tawm hauv lub cev tom qab 1.5-2 teev, nws cov khoom lag luam metabolic tsoo qeeb dua, lub sijhawm ntawm lawv cov kev tshem tawm yuav siv 6-9 teev. Cov tshuaj feem ntau tsuas yog tawm ntawm lub raum thiab txoj hnyuv.
Kev taw qhia thiab contraindications
Cov tshuaj Blocktran thiab tshuaj yeeb yaj kiab ntawm cov tshuaj tau hais tawm tsuas yog pom zoo los ntawm kws kho mob nrog kev paub tseeb. Noj cov tshuaj yog kev pom zoo rau kev mob ntshav siab ntshav liab thiab txoj hlab plawv tsis ua haujlwm. Cov tshuaj yuav yog ib feem ntawm cov kev kho mob nyuaj rau cov neeg mob uas nkag rau ACE inhibitors.
Nws txo txoj kev pheej hmoo ntawm kev loj hlob ntawm cov kab mob loj ntawm lub plawv thiab cov hlab ntsha, kev tuag ntawm cov neeg mob uas mob ntshav siab ua ke nrog sab laug ventricular hypertrophy. Daim ntawv ntawm contraindications rau siv muaj:
- hypotension
- lub cev qhuav dej thiab hyperkalemia,
- hnub nyoog txog 18 xyoo
- cev xeeb tub thiab lactation
- kev mob siab ntev rau cov tshuaj hauv cov tshuaj muaj pes tsawg leeg,
- nce nyob rau hauv tus naj npawb ntawm poov tshuaj ions nyob rau hauv cov ntshav cov ntshav,
- lub cev qhuav dej.
Cov neeg mob uas muaj teeb meem hauv kev ua haujlwm ntawm lub raum thiab daim siab yog sau tseg rau Blocktran hauv kev txwv ntau npaum li cas kom tsis txhob ua kom tsis txhob mob. Tus naj npawb ntawm cov ntsiav tshuaj thaum lub sij hawm kho yuav tsum tsis muaj dab tsi, kev noj tshuaj ntau dhau yuav ua rau muaj kev phom sij txog ntawm kev tuag.
Kub siab tshuaj
Txoj kev ntawm daim ntawv thov
Thaum nws hais txog dab tsi Blocktran pab los ntawm, nws tsim nyog teev cais yuav ua li cas nws siv. Lub cuab yeej yuav tsum tau noj ib zaug hauv daim ntawv ntawm qhov ncauj, tsis pub tshaj qhov muab tshuaj los ntawm tus kws kho mob hauv cov tshuaj. Cov neeg mob mob ntshav siab tau noj tshuaj 50 mg ib hnub twg. Yog tias lub hom phiaj ua kom tau txais ntau qhov kev hais lus, qhov nyiaj no tau nce mus rau 100 mg ib hnub lossis faib nrog 50 mg thaum noj ob zaug ib hnub. Cov neeg mob uas muaj lub plawv tsis ua haujlwm yam tsawg 12,5 mg ib hnub twg.
Feem ntau, qhov ntau npaum li cas tau nce ntxiv nyob rau hauv ncua sij hawm ntawm ib lub lis piam mus rau theem nrab, qhov kawg nruab nrab yog tsawg kawg yog 50 mg rau ib hnub. Yog tias tus neeg mob yuav siv ntau npaum li cas ntawm diuretics, koob tshuaj yog txo rau 25 mg ib hnub twg. Nrog rau kev ua mob rau daim siab, Blocktran tau sau tseg nrog kev ceev faj thiab ntawm kev noj tshuaj tsawg dua. Nws yuav tsum tau yug los rau hauv lub siab tias thaum lub sijhawm kho nws yuav tsum tau saib xyuas qib theem ntawm cov poov tshuaj hauv cov ntshav, tshwj xeeb tshaj yog thaum nws los txog rau cov neeg mob hnub nyoog lossis lub raum teeb meem.
Phiv thiab haus tshaj
Blocktran cov tshuaj yog npaj los ua kom cov ntshav siab thiab tuaj yeem pab tus neeg mob thaum saib xyuas cov tshuaj ntau npaum li cas los ntawm kws kho mob. Yog tias muaj kev noj ntau dhau, qhov kev txais tos nres, tus neeg mob lub plawv thiab lub ntsws tau kuaj pom, thiab cov tsos mob kho tau yog kho. Qhov no suav nrog kev kho mob plab zom mov, tshem tawm cov teeb meem electrolyte, coma thiab lub cev qhuav dej, kev teem sij hawm tshuaj nce siab.
Daim ntawv teev cov kev mob tshwm sim suav nrog:
- teeb meem pw tsaug zog, mob taub hau thiab kiv taub hau, nco qab tsis meej, nkees heev thiab kev nyuaj siab,
- kev pom, qhov ntxhov siab, tsw qab,
- mob ntsws, hnoos qhuav, mob ntsws,
- dyspepsia, tsis txaus los yog nce hauv qab los noj mov, mob plab, cem quav, zoo nkaus rau lub qhov ncauj qhuav,
- mob thiab mob hauv cov leeg nqaij ntawm ob txhais ceg thiab sab nraub qaum, tshwm sim ntawm mob caj dab,
- muaj teeb meem nrog lub siab, arrhythmia, angina pectoris lossis tachycardia,
- mob txeeb zig.
Qee tus neeg mob yuav muaj kev tsis haum tshuaj, ua pob, ua pob, ntau heev tshav ntuj. Feem ntau, cov tshuaj tau zoo rau hauv txhua theem ntawm kev tswj hwm, yog li nws tuaj yeem tsim kho yam tsis muaj kev txwv tsis pub pom qhov tsis pom tseeb. Feem ntau cov kev mob tshwm sim ploj tom qab kev txiav tawm ntawm cov tshuaj, uas hloov los ntawm ib qho analogue.
Noj tshuaj
Cov lus pom zoo tshwj xeeb
Yog tias tus neeg mob nws lub cev qhuav dej ib zaug thaum kho cov tshuaj Blocktran, nws tau nquahu kom pib cov tshuaj ntawm tsawg kawg. Nrog kev ua kom ntshaus ntawm cov hlab ntsha ntawm ob lub raum, cov tshuaj muaj peev xwm nce cov concentration ntawm creatinine thiab urea hauv cov ntshav cov ntshav. Thaum noj tshuaj, nws yog ib qho tsim nyog los soj ntsuam cov poov tshuaj hauv ntshav ntxiv, qhov no siv rau cov neeg laus thiab cov neeg mob lub raum tsis ua haujlwm.
Cov hlaws tsis ua tiav tsis yog vim li cas thiaj li txo qhov tshuaj, nws tsuas yog xav kom raug txo kom tsawg. Cov tshuaj tsis yog kws kho mob txog thaum muaj hnub nyoog 18 xyoo, nws txoj kev siv yog tso cai rau cov neeg laus, coj mus rau hauv tus account kev soj ntsuam tas li ntawm lub xeev ntawm lawv cov hlab plawv, kuaj ntshav thiab lwm yam ntsuas. Blocktran tuaj yeem muas tau hauv khw muag tshuaj tsuas yog cov kws kho mob ua ntawv sau.
Cov ncauj lus kom ntxaws txog cov tshuaj muaj ntxiv nyob rau hauv cov yeeb yaj kiab hauv qab no:
Tawg - nws yog dab tsi?
Los ntawm lub sijhawm xws li "mob ntshav liab" txhais tau tias nce ntshav siab ntau dua 140/90 hli Hg. Kos duab. Qee lub sij hawm nws yog qhov pib ntawm tus kheej los yog tus kab mob ywj siab uas nthuav dav hauv tus neeg mob yam tsis muaj laj thawj dab tsi (mob ntshav siab). Thiab qee zaum nws dhau los ua ib qho kev phom sij lossis kev rau txim ntawm lwm yam kab mob (mob raum). Xws li cov kab mob plawv yog qhov tshwm sim ntau tshaj plaws, nws yog nws ua rau ntau lab tus tib neeg thoob ntiaj teb mus cuag kws kho mob txhua hnub kom tau txais kev pab. Tsawg paub nws yog dab tsi.
Arterial hypertension tsis yog tsuas yog nce ntxiv tus nqi. Tus kab mob no zais tag nrho cov kev muaj ntau yam kev mob cuam tshuam los ntawm cov leeg hlwb, cov hlab ntshav, ob lub raum thiab lub plawv, uas cuam tshuam ncaj qha rau tus neeg mob lub cev.
Arterial hypertension yog ib qho ua rau muaj kev ploj tuag ntawm cov tub ntxhais hluas muaj peev xwm kis tau mob, vim tias qhov kev phom sij tshaj plaws ntawm cov kab mob no yog qhov ua txhaum ntawm cov ntshav ncig ntawm lub hlwb lossis mob hlab ntsha tawg.
Cov tshuaj muaj pes tsawg leeg
Ib ntsiav tshuaj ntawm Blocktran tshuaj suav nrog tsib caug milligrams ntawm losartan potassium. Cov khoom siv ntxiv: microcrystalline cellulose, lactose monohydrate, tsis tshua muaj molecular phaus povidone, sodium carboxymethyl hmoov txhuv nplej siab, silicon dioxide, qos hmoov txhuv nplej siab, magnesium stearate. Lub plhaub muaj pes tsawg leeg: titanium dioxide, daj zas xim, hnub poob, hypromellose, talc, copovidone, polysorbate 80.
Ib ntsiav tshuaj ntawm Blocktran GT suav nrog hydrochlorothiazide (12.5 mg) thiab potassium losartan (50 mg). Cov khoom siv ntxiv: microcrystalline cellulose, lactose monohydrate, tsis tshua muaj molecular phaus povidone, sodium carboxymethyl hmoov txhuv nplej siab, hmoov txhuv nplej siab, silicon dioxide, magnesium stearate.
Cov tshuaj muaj pes tsawg leeg muaj cov kab mob hypromellose, polydextrose, liab zas carmine, nruab nrab saw triglycerides, talc, maltodextrin, titanium dioxide.
Blocktran GT tshuaj dab tsi rau? Qhov no yuav tham txog tom qab.
Ceev faj kev noj tshuaj
Nrog kev ceev faj, Blocktran GT siv nyob rau hauv cov xwm txheej hauv qab no:
- Kev ua txhaum ntawm cov dej-electrolyte tshuav, piv txwv li, tawm tsam keeb kwm ntawm ntuav lossis raws plab (hyponatremia, hypokalemia, hypomagnesemia, hypochloremic alkalosis).
- Hauv cov neeg mob uas lub raum tsis ua haujlwm (kev tsim muaj peev xwm tshem tau ntau tshaj 30 ml / min), nrog stenosis ntawm cov leeg ntawm ib lub raum (ib leeg) thiab stenosis ob leeg ntawm cov hlab ntsha ntawm ob lub raum.
- Thaum muaj teeb meem daim siab tsis zoo (hauv qab 9 ntsiab lus raws li Child-Pugh).
- Nyob rau ntawm muaj gout thiab / lossis hyperuricemia, hypercalcemia, mob ntshav qab zib mellitus, nrog rau kev muaj mob tsis haum lub keeb kwm (tsim mob mob hlwb ntawm qee cov neeg mob yav dhau los nrog kev siv lwm yam tshuaj, suav nrog ACE inhibitors), mob ntsws asthma, nrog cov kab mob ntawm cov kab mob sib txuas (nrog rau cov kab mob lupus erythematosus) Cov.
- Nrog hypovolemia (suav nrog tiv thaiv keeb kwm ntawm kev txhaj tshuaj loj ntawm diuretics),
- Cov neeg mob uas mob nrawm dua ntawm lub kaum kaw lub ntsej muag.
- Thaum tau muab tshuaj noj nrog rau cov tshuaj tua kab mob uas tsis yog tshuaj steroidal, suav nrog 2 hom cyclooxygenase inhibitors, nrog rau kev mob plawv glycosides.
- Cov neeg mob uas muaj mob rau cov ntshav plawv, cov neeg laus.
Dosage ntawm yeeb tshuaj
Cov cuab yeej "Blockchain GT" nrog kev mob ntshav siab yog siv sab hauv, tsis hais kev noj zaub mov, qhov ntau zaus ntawm kev tswj hwm - ib hnub ib zaug.
Kev tu thiab thawj zaug tshuaj yog sib npaug rau ib ntsiav tshuaj ib hnub ib zaug. Qee qhov xwm txheej, txhawm rau kom ua tiav cov txiaj ntsig zoo dua, nws tau nce rau ob daim ib hnub ib zaug. Qhov siab tshaj plaws nyob rau ib hnub twg yog ob ntsiav tshuaj ntawm Blocktran GT.
Yuav kom kho qhov tsuas ntau npaum li cas hauv cov neeg laus lossis cov neeg mob lub raum tsis ua hauj lwm los ntawm kev txiav txim siab tsis yog.
Txhawm rau txo txoj kev pheej hmoo ntawm kev txhim kho lub plawv thiab cov hlab ntsha thiab kev tuag ntawm cov neeg mob laug laug ventricular hypertrophy thiab mob ntshav siab, cov tshuaj tau raug txiav txim raws li cov qauv hauv qab no. Tus txheej txheem thawj zaug tshuaj ntawm Blocktran GT yog 50 mg ib hnub ib zaug. Cov neeg mob uas tsis tuaj yeem ua tiav qhov kev nyuaj siab thaum noj cov tshuaj ntawm losartan yuav tsum xaiv qhov kev kho mob los ntawm kev sib xyaw nrog losartan nrog hydrochlorothiazide me me, yog tias tsim nyog, qhov tshuaj ntawm losartan tau nce rau 100 mg ib txhij nrog 12.5 mg ntawm hydrochlorothiazide ib hnub, tom qab ntawd nce koob tshuaj rau ob ntsiav tshuaj (tag nrho ntawm 25 milligrams ntawm hydrochlorothiazide thiab 100 milligrams ntawm losartan ib zaug ib hnub).
Kev tiv thaiv tsis zoo
Dab tsi yog cov kev mob tshwm sim ntawm GT Blocktran? Tus naj npawb ntawm cov tsos mob tsis zoo yog raug cais raws qhov txiaj ntsig tau tsim los ntawm World Health Organization.
Hauv kev sim tshuaj nrog hydrochlorothiazide / losartan, tsis muaj kev phiv los cuam tshuam rau tus neeg sawv cev ua ke no tau pom. Cov xwm txheej tsis zoo tau raug txwv rau cov uas yuav tham txog tom qab (thaum saib hydrochlorothiazide thiab losartan cais).
Cov kev mob tshwm sim hauv qab no tau pom nrog kev siv hydrochlorothiazide thiab losartan hauv kev kho mob monotherapy.
Kev phiv tshuaj rau Losartan
Lymphatic system thiab ntshav: ua haujlwm tsis xws luag - hemolytic anemia, ecchymoses, Shenlein-Genoch liab, ntshav liab.
Kev ua xua: tsis tshua muaj - urticaria, angioedema, anaphylactic kev tsis haum.
Los ntawm ib sab ntawm khoom noj khoom haus thiab metabolism hauv: tsis xws luag - exacerbation ntawm tus yam ntxwv ntawm gout, anorexia.
Los ntawm lub hauv nruab nrab hauv lub paj hlwb: tsis txaus ntseeg - nco tsis meej, ntxhov siab, pw tsis tsaug zog, kab mob sib txawv, tsaug zog, mob peripheral neuropathy, kev nyuaj siab, tshee, ntxhov siab, mob taub hau, ceeb kev ntshaus siab, tsaus muag, ntxhov siab vim, ntxhov siab, feem ntau insomnia, kiv taub hau, mob taub hau Cov.
Nyob rau ib feem ntawm cov khoom siv hauv qhov muag pom tau: kev nkag siab - qhov khaus khaus thiab qhov nyob hauv qhov muag, lub qhov muag tsis pom kev, txo qhov muag pom, qhov muag pom.
Los ntawm cov kab mob hnov: ua rau tsis tuaj yeem - tinnitus, vertigo.
Ntawm ib feem ntawm cov kab mob ua pa: feem ntau - hnoos, mob ntswg, txhawm rau lub ntsws ua pa (pharyngitis, sinusitis, mob ntsws, mob caj pas, lub cev kub), ua tsis tau - tsis xis nyob rau pharynx, ntswg, rhinitis, mob ntsws, mob ntsws, mob ntsws, mob ntsws pharyngitis.
Los ntawm lub plab hnyuv plab hnyuv siab raum: feem ntau - dyspeptic tshwm sim, raws plab, mob plab, xeev siab, hleb - mob hniav, qhuav qog ua pa ntawm lub qhov ncauj kab mob, cem quav, mob plab, plab, ntuav.
Musculoskeletal system: ua haujlwm tsis xws luag - mob hauv caug, xub pwg, caj npab, mob caj dab, mob fibromyalgia, mob caj dab, mob leeg tsis muaj zog, mob leeg, mob pob txha, mob pob txha, feem ntau mob ntawm ob txhais ceg thiab sab nraub qaum, myalgia, cramps.
Los ntawm ib sab ntawm lub plawv thiab cov hlab ntshav system: ua haujlwm tsis tu ncua - koob tshuaj-orthostatic hypotension, leeg ntshav hypotension, mob ntshav siab los yog tachycardia, palpitations, angina pectoris, arrhythmias, II degree ntawm AV block, mob hauv siab, vasculitis, myocardial infarction, cerebrovascular cov xwm txheej.
Los ntawm cov kab mob genitourinary: ua haujlwm tsis meej - impotence, txo qis libido, tso zis mob txeeb zig, tso zis tsis tu ncua, tsis muaj dab tsi.
Los ntawm daim tawv nqaij ua ke: tsis xws luag - erythema, tawv nqaij qhuav, ntshav "maj" rau ntawm daim tawv nqaij ntawm lub ntsej muag, dermatitis, photosensitivity, alopecia, khaus ntawm daim tawv nqaij, tawm hws ntau dhau, ua pob tawv nqaij.
Lwm qhov kev tshwm sim: feem ntau - kev qaug zog ntau dhau, asthenia, tsis xws luag - kub taub hau, o ntawm lub ntsej muag.
Qhov ntsuas pom: ua tsis tau - cov ntsiab lus siab dua ntawm creatinine thiab urea, feem ntau - txo qis ntawm hemoglobin thiab hematocrit, hyperkalemia, tsis tshua muaj - kev ua si ntawm daim siab hloov ntshav siab.
Ntawm hydrochlorothiazide
Lymphatic system thiab ntshav: ua haujlwm tsis xws luag - thrombocytopenia, agranulocytosis, purpura, aplastic anemia, leukopenia, hemolytic anemia.
Kev ua xua rau: muaj tsawg dua - kev phiv tshuaj anaphylactic.
Khoom noj khoom haus thiab metabolism: qog - hyponatremia, anorexia, hypokalemia, hyperglycemia, hypokalemia, hyperuricemia.
Los ntawm cov hlab ntsha hauv plab: tsis xws luag - pw tsaug zog, kiv taub hau, ntau zaus - mob taub hau.
Los ntawm ob sab ntawm qhov muag pom cov plab hnyuv siab raum: ua haujlwm sab hauv - xantopsia, mob tsis pom kev dhau los.
Los ntawm cov kab ke ntawm lub plawv thiab cov hlab ntshav: tsis tshua muaj - necrotizing vasculitis.
Lub plab ua pa ntawm lub cev: ua haujlwm tsis dhau - pulmonary edema, mob ntsws, mob ntsws ua pa nyuaj.
Cov kab mob hauv plab: tsis tshua muaj - sialodenitis, pancreatitis, mob chraestatic cholestasis (mob daj ntseg), mob voos rau txoj hnyuv, mob caj dab tsis txaus, ua rau mob plab, ntuav, daj ntseg, ntuav, cem quav, raws plab.
Los ntawm cov nqaij mos subcutaneous thiab tawv nqaij: ua haujlwm tsis xws luag - urticaria, photosensitivity.
Los ntawm cov leeg musculoskeletal: tsis tshua muaj - nqaij mob ntswj.
Los ntawm cov kab mob ntawm lub urinary: tsis tshua muaj - cuam tshuam lub raum kev ua haujlwm, glucosuria, raum tsis ua haujlwm, interstitial nephritis.
Cov teeb meem dav dav: tsis tshua muaj - kub taub hau.
Yog tias muaj kev tshaj tawm tom qab muag siv hydrochlorothiazide / losartan, tom qab ntawd cov kev mob tshwm sim txuas ntxiv:
- los ntawm lub plab zom mov sai - kab mob siab,
- kev ntsuas tsom ntsuas: tsis tshua muaj - nce siab transaminase kev ua haujlwm, hyperkalemia.
Tshuaj Ntsuam Xyuas
Kev txheeb xyuas txog GT Blocktran ua tim khawv rau nws txoj kev muaj peev xwm txo qis, tab sis tib lub sijhawm, kev mob tshwm sim thaum siv tshuaj ntau heev, feem ntau yog mob sib koom tes thiab qaug zog.
Cov neeg hais tias cov tshuaj muaj txiaj ntsig zoo, muaj qhov raug zoo ntawm lub xeev. Qhov teeb meem nkaus xwb uas txaus siab rau ntau tus neeg mob yog qhov tsis muaj tshuaj nyob hauv cov chaw muag tshuaj, nws cia li ploj mus vim tsis paub meej.
Qee lub sij hawm qhov kev ua tau zoo ntawm cov tshuaj tau muab sau tseg rau lub sijhawm, tab sis tom qab ib xyoo nws cov nyhuv poob qis.
Tus nqi ntawm Blocktran GT hauv Russia pib ntawm 160 rubles. Nws nyob ntawm thaj av thiab cov tsev muag tshuaj lub network.