Rosuvastatin sz > Tshuaj Kho Mob

Stabilizes qib qab zib kom ntev
Rov kho cov tshuaj insulin pancreatic

Peb cov neeg nyeem tau siv Aterol ua tiav kom qis cov roj (cholesterol). Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Rosuvastatin SZ (Qaum Teb Hnub Qub) nyob nrog pab pawg ntawm cov statins uas muaj teeb meem lipid-txo qis.

Cov tshuaj tau zoo siv rau cov kab mob cuam tshuam nrog kev txhim kho lipid metabolism, zoo li kev tiv thaiv ntawm cov kab mob plawv. Cov ntsiab lus ntxaws ntxiv txog cov tshuaj muaj peev xwm nrhiav tau hauv cov khoom siv no.

Ntawm kev lag luam pharmacological, koj tuaj yeem pom ntau cov tshuaj uas muaj cov tshuaj rosuvastatin, nyob hauv ntau hom. Rosuvastatin SZ yog tsim los ntawm tus tsim khoom lag luam hauv tebchaws Severnaya Zvezda.

Ib ntsiav tshuaj muaj 5, 10, 20 lossis 40 mg ntawm rosuvastatin calcium. Nws qhov tseem ceeb suav nrog kua mis qab zib, povidone, sodium stearyl fumarate, primellose, MCC, aerosil thiab calcium hydrophosphate dihydrate. Rosuvastatin SZ ntsiav tshuaj yog biconvex, muaj cov qauv puag ncig thiab tau them nrog lub plhaub paj yeeb.

Cov nquag ua ke yog tshuaj tiv thaiv HMG-CoA reductase. Nws qhov kev ua haujlwm yog tsom rau nce tus naj npawb ntawm hepatic LDL enzymes, txhim kho cov dissimilation ntawm LDL thiab txo lawv cov lej.

Raws li kev siv cov tshuaj, tus neeg mob tswj los txo cov theem "phem" cov roj (cholesterol) thiab nce qhov siab ntawm "zoo". Cov txiaj ntsig zoo tuaj yeem pom tau twb tau 7 hnub tom qab pib kev kho mob, thiab tom qab 14 hnub nws tuaj yeem ua tiav 90% ntawm cov nyhuv siab tshaj plaws. Tom qab 28 hnub, lipid metabolism rov qab mus rau qhov qub, tom qab uas yuav tsum tau kho kev kho mob.

Cov ntsiab lus siab tshaj plaws ntawm rosuvastatin raug pom nyob 5 teev tom qab kev tswj hwm ntawm qhov ncauj.

Yuav luag 90% ntawm cov tshuaj nquag khi rau albumin. Nws tshem tawm ntawm lub cev yog nqa tawm los ntawm txoj hnyuv thiab raum.

Kev taw qhia thiab contraindications rau siv

Rosuvastatin-SZ yog kho rau lub cev lipid metabolism tsis zoo thiab rau kev tiv thaiv cov kab mob plawv.

Raws li txoj cai, kev siv cov ntsiav tshuaj no yuav tsum ua raws li kev noj haus hypocholesterol thiab tawm dag zog.

Cov ntawv qhia kev qhia muaj cov cim qhia hauv qab no rau kev siv:

thawj, tsev neeg homozygous los yog sib xyaw hypercholesterolemia (ntxiv rau cov tshuaj tsis siv tshuaj ntawm kev kho),
hypertriglyceridemia (IV) ntxiv rau kev noj haus tshwj xeeb,
atherosclerosis (rau inhibit qhov cia ntawm cov roj hauv plaques thiab normalize qib ntawm tag nrho cov roj (cholesterol) thiab LDL),
kev tiv thaiv mob stroke, arterial revascularization thiab plawv nres (yog tias muaj qee yam xws li hnub nyoog laus, qib C-reactive protein, haus luam yeeb, noob caj noob ces thiab ntshav siab).

Tus kws kho mob txwv tsis pub noj tshuaj Rosuvastatin SZ 10mg, 20mg thiab 40mg yog tias nws kuaj pom hauv tus neeg mob:

Cov tib neeg lub siab tsis haum rau Cheebtsam.
Kev mob raum tsis zoo (nrog QC; Kev qhia rau kev siv tshuaj

Cov ntsiav tshuaj yuav tsum nqos tag nrho nrog ib khob ntawm dej haus. Lawv tau noj tsis hais lub sijhawm twg los xij nyob rau hnub ntawd.

Ua ntej pib thiab thaum siv tshuaj kho mob, tus neeg mob tsis kam lees cov khoom xws li cov leeg (mob raum, mob hlwb), qe qe, nqaij npuas, lard, lwm cov khoom noj muaj roj, cov khoom ci los ntawm cov hmoov zoo, chocolate thiab khoom qab zib.

Tus kws kho mob txiav txim siab qhov ntau npaum li cas ntawm cov tshuaj raws li theem ntawm cov cholesterol, cov hom phiaj kho thiab tus yam ntxwv ntawm tus neeg mob.

Thawj koob tshuaj rosuvastatin yog 5-10 mg ib hnub twg. Yog tias nws tsis tuaj yeem ua tiav qhov txiaj ntsig uas xav tau, ntau npaum li cas ntxiv rau 20 mg nyob rau hauv kev saib xyuas nruj ntawm tus kws tshaj lij. Kev saib xyuas zoo kuj tseem ceeb thaum sau tshuaj 40 mg ntawm cov tshuaj, thaum tus neeg mob kuaj pom tias muaj tus mob hypercholesterolemia ntau heev thiab muaj feem ntau ntawm cov mob plawv.

14-28 hnub tom qab pib kev siv tshuaj, nws yog ib qho tsim nyog los soj qab cov lipid metabolism.

Tsis tas yuav hloov kho qhov ntau ntawm cov tshuaj rau cov neeg mob laus thiab cov neeg txom nyem los ntawm lub raum tsis ua haujlwm. Nrog caj ces polyformism, ib qho kev nyiam rau myopathy lossis koom nrog haiv neeg Mongoloid, cov koob tshuaj lipid-txo qis tus neeg sawv cev yuav tsum tsis pub tshaj 20 mg.

Qhov kev tswj hwm kub ntawm cia ntawm cov tshuaj ntim tsis yog ntau tshaj 25 degrees Celsius. Txee lub neej yog 3 xyoos. Khaws qhov ntim rau hauv qhov chaw tiv thaiv los ntawm ya raws thiab tshav ntuj.

Sab Caj Ces Thiab Nkawv Sib Txawv

Tag nrho cov npe ntawm cov kev mob tshwm sim thaum tshwm sim thaum siv cov tshuaj tau piav qhia nyob rau hauv cov lus qhia rau kev siv.

Raws li txoj cai, kev phiv thaum noj cov tshuaj no tsis tshua muaj mob.

Txawm hais tias qhov pom ntawm qhov tshwm sim tsis zoo, lawv muaj mob me thiab ploj mus lawv tus kheej.

Hauv cov lus qhia rau kev siv, cov npe hauv qab no ntawm cov kev mob tshwm sim:

Endocrine system: kev txhim kho ntawm qhov tsis yog-insulin-mob ntshav qab zib mellitus (hom 2).
Kev tiv thaiv kab mob: Quincke edema thiab lwm yam kev tiv thaiv tsis pom qab.
CNS: kiv taub hau thiab mob taub hau.
Cov kab mob hauv lub cev: proteinuria.
Lub plab zom mov plab: muaj mob dyspeptic, epigastric mob.
Cov leeg mob: myalgia, myositis, myopathy, rhabdomyolysis.
Daim tawv nqaij: khaus, khaus thiab ua pob.
Biliary system: pancreatitis, siab ua haujlwm ntawm hepatic transaminases.
Qhov ntsuas pom: hyperglycemia, theem siab ntawm bilirubin, alkaline phosphatase, GGT kev ua haujlwm, cuam tshuam cov thyroid kev ua haujlwm tsis zoo.

Raws li cov txiaj ntsig tom qab kev tshawb fawb txog kev lag luam, kev tiv thaiv tsis zoo tau txheeb xyuas:

thrombocytopenia
daj daj ntseg thiab kab mob siab
Stevens-Johnson mob
nco qab tsis zoo
ua ke puffiness,
ntshav qab zib polyneuropathy,
gynecomastia
hematuria
txog siav thiab ua pa hnoos,
arthralgia.

Qee qhov xwm txheej, kev siv cov Rosuvastatin SZ nrog rau lwm cov tshuaj tuaj yeem ua rau cov kev tsis tuaj yeem pom. Hauv qab no yog cov yam ntxwv ntawm kev tswj hwm kev sib txuam ua ke ntawm cov tshuaj hauv cov lus nug nrog lwm tus:

Thauj cov protein blockers - kev nce ntxiv ntawm kev pheej hmoo ntawm myopathy thiab nce ntxiv ntawm rosuvastatin.
Cov kab mob HIV tiv thaiv kab mob tiv thaiv - muaj kev cuam tshuam ntau ntxiv ntawm cov tshuaj nquag.
Cyclosporine - kev nce qib ntawm rosuvastatin los ntawm ntau dua 7 zaug.
Gemfibrozil, fenofibrate thiab lwm yam fibrates, nicotinic acid - qib siab ntawm cov tshuaj nquag thiab muaj kev pheej hmoo ntawm myopathy.
Erythromycin thiab antacids muaj aluminium thiab magnesium hydroxide - txo cov ntsiab lus ntawm rosuvastatin.
Ezetimibe - kev nce siab hauv kev xav tau ntawm cov nquag nquag.

Txhawm rau tiv thaiv kev txhim kho ntawm qhov tshwm sim tsis zoo vim kev sib txuam ntawm kev siv tshuaj sib txuam, nws yog ib qho tsim nyog yuav tsum qhia rau tus kws kho mob txog txhua yam kab mob sib kis.

Nqe, tshuaj xyuas thiab analogues

Txij li cov tshuaj Rosuvastatin yog tsim los ntawm lub Hoobkas kev tsim tshuaj "North Star", nws tus nqi tsis siab dhau. Koj tuaj yeem yuav cov tshuaj hauv txhua lub tsev muag tshuaj hauv zos.

Tus nqi ntawm ib pob muaj 30 ntsiav tshuaj ntawm 5 mg txhua yog 190 rubles, 10 mg txhua yog 320 rubles, 20 mg txhua yog 400 rubles, thiab 40 mg txhua tus yog 740 rubles.

Ntawm cov neeg mob thiab cov kws kho mob, koj tuaj yeem nrhiav ntau cov kev txheeb xyuas zoo txog cov tshuaj. Ib qho loj ntxiv yog tus nqi pheej yig thiab muaj txiaj ntsig kho tau zoo. Txawm li cas los xij, qee zaum muaj kev tshuaj xyuas tsis zoo uas cuam tshuam nrog lub xub ntiag ntawm cov kev mob tshwm sim.

Eugene: “Kuv pom tias tau ua txhaum lipid metabolism ntev dhau los. Rau txhua lub sijhawm kuv sim ntau yam tshuaj. Ua ntej siv Liprimar, tab sis tawm haujlwm, vim tias nws tus nqi yog txiav txim siab. Tab sis txhua xyoo kuv yuav tsum ua kom poob kua dej kom pub cov hlab ntsha ntawm lub hlwb. Tom qab ntawd tus kws kho mob tau sau Krestor rau kuv, tab sis dua nws tsis yog los ntawm cov tshuaj pheej yig. Kuv tus kheej pom nws cov analogues, cov uas yog Rosuvastatin SZ. Kuv tseem niaj hnub noj cov tshuaj no, Kuv zoo siab heev, kuv cov roj (cholesterol) tau rov qab zoo li qub. "

Tatyana: “Lub caij ntuj sov, theem ntawm cov roj (cholesterol) tau nce mus txog 10, thaum tus qauv yog 5.8. Hloov mus rau tus kws kho mob, thiab nws tau sau ntawv rau kuv Rosuvastatin. Tus kws kho mob tau hais tias cov tshuaj no tsawg dua rau ntawm daim siab. Kuv tabtom noj Rosuvastatin SZ thaum lub sijhawm, hauv txoj hauv kev, txhua yam zoo, tab sis muaj ib "tab sis" - qee zaum mob taub hau txhawj. "

Cov khoom xyaw nquag rosuvastatin muaj nyob hauv ntau cov tshuaj uas tau tsim los ntawm cov tuam txhab sib txawv. Txhais cov ntsiab lus suav nrog:

Akorta,
Neeg Coob
Mertenil
Rosart,
Ro statin
Rosistark,
Rosuvastatin Canon,
Kwv Txhiaj Ntsuag
Xeb.

Nrog tus neeg mob siab rau rosuvastatin, tus kws kho mob xaiv cov tshuaj tiv thaiv zoo, i.e. tus neeg sawv cev uas muaj lwm qhov kev tiv thaiv, tab sis ua tib yam lipid-txo cov nyhuv. Hauv tsev muag tshuaj koj tuaj yeem yuav cov tshuaj zoo sib xws no:

Qhov loj tshaj plaws hauv kev kho mob siab cov ntshav siab yog ua raws li txhua qhov kev pom zoo ntawm cov kws tshaj lij tuaj koom, ua raws li kev noj zaub mov noj thiab ua kom lub neej muaj sia. Yog li, nws yuav muaj peev xwm los tswj tus mob thiab tiv thaiv ntau yam teeb meem.

Cov tshuaj Rosuvastatin SZ tau piav qhia hauv kev nthuav dav hauv video hauv kab lus no.

Stabilizes qib qab zib kom ntev
Rov kho cov tshuaj insulin pancreatic

Kev tshuaj xyuas ntawm cov tshuaj uas txo cov roj cholesterol

Txhawb cov roj hauv cov ntshav siab yog ib qho ntawm cov kev mob plawv. Cov roj (cholesterol) yog ib yam khoom noj uas ua rog, qhov feem tseem ceeb uas yog tsim tawm hauv lub siab (li 80%) thiab ib feem los nrog zaub mov noj (kwv yees li 20%). Nws muab cov tshuaj tiv thaiv kab mob rau hauv lub cev, koom nrog kev tsim cov tshuaj hormones steroid thiab cov kua tsib kua qaub, tswj hwm kev ua haujlwm ntawm cov hlab ntsha hlwb, yog qhov tsim nyog hauv kev tsim cov cell week.

Maj mam, cov roj cholesterol tsim nyob rau hauv lub cev thiab tawm tsam ntawm cov hlab ntshav ntsa hauv daim ntawv ntawm atherosclerotic plaques. Raws li qhov ua tiav, lub lumen ntawm cov hlab ntsha nqaim, cov ntshav ncig yuav nyuaj, cov pa oxygen thiab cov khoom noj khoom haus mus rau cov ntaub so ntswg thiab cov kabmob, nrog rau lub hlwb thiab lub siab, muaj kev cuam tshuam. Qhov no yog li cas ischemia, myocardial infarction thiab mob stroke nthuav dav.

Cov roj khov ua rau cov ntshav nkag ua ke nrog cov protein hu ua lipoproteins. Qhov kawg yog ntawm ob hom HDL (siab ceev) thiab LDL (tsis tshua muaj siab). Qhov thib ib yog cov roj (cholesterol) zoo. LDL yog qhov muaj kev phom sij, nws yog nws qhov ntau tshaj yog txaus ntshai rau lub cev.

Leej twg yuav tsum noj tshuaj pab mob ntshav txhauv?

Cov kws kho mob muaj cov cwj pwm sib txawv ntawm kev siv tshuaj, ntau tus ntseeg tias vim muaj ntau cov kev mob tshwm sim, lawv txoj kev siv tsis ncaj ncees. Ua ntej koj pib noj cov tshuaj zoo li no, koj yuav tsum sim kom ua tiav cov txiaj ntsig nrog kev pab ntawm kev noj haus, muab lub cev tsis zoo, ua kom lub cev qoj ib ce. Txawm li cas los xij, hauv qee kis, kev noj cov tshuaj zoo li no yog qhov tsim nyog. Pawg no suav nrog cov neeg muaj kab mob ua rau mob hlab ntsha, nrog ischemia muaj qhov pheej hmoo ntawm lub plawv nres, nrog cov keeb tiv thaiv kab mob siab ntxiv rau cov roj (cholesterol), uas tau muaj mob plawv lossis mob hlab ntsha tawg.

Cov Tshuaj Noj Roj

Txoj kev kho yog nqa tawm siv tshuaj ntawm ob pawg: statins thiab fibrates. Txhawm rau txo cov ntshav hauv cov ntshav siab, statins feem ntau siv. Niaj hnub no nws yog qhov ua tau zoo tshaj plaws. Lawv qhov kev ua yog lawv tiv thaiv kev tsim cov roj (cholesterol) phem los ntawm kev txo cov enzymes uas tsim nyog rau qhov no. Yog li, lawv tiv thaiv qhov tsim ntawm atherosclerotic plaques thiab txhaws ntawm cov hlab ntshav, uas txhais tau hais tias lawv txo qis kev pheej hmoo ntawm lub plawv thiab leeg ntshav.

Statins yog cov tshuaj uas txo cov roj (cholesterol) phem thiab nce ntxiv. Tom qab lawv tau txais, cov theem ntawm cov dav dav poob los ntawm 35-45 feem pua, thiab theem ntawm tsis zoo - los ntawm 40-60 feem pua.

Koj yuav tsum paub tias cov tshuaj no muaj ntau cov kev mob tshwm sim, yog li koj yuav tsum coj lawv tsuas yog nyob hauv kev saib xyuas ntawm cov kws kho mob. Statins cuam tshuam ntau yam rau ntau lub cev, thaum cov teeb meem tshwm sim tsis tuaj yeem tshwm sim tom qab kev tswj hwm, tab sis tom qab qee lub sijhawm. Ntawm cov kev phiv loj yog:

kiv taub hau
pw tsaug zog
mob taub hau
nco qab tsis zoo
parasthesia
amnesia
lub plawv dhia
raws plab thiab quav tawv,
xeev siab
kab mob siab
qhov muag cataract
pancreatitis
mob ib ce
kev tawm tsam ua xua ntawm daim tawv nqaij ua pob thiab khaus,
peripheral edema,
ua txhaum cai ntawm kev sib deev,
metabolic ntshawv siab.

kev npaj xeeb tub, lub sijhawm xeeb tub thiab kev pub niam mis,
cov me nyuam hnub nyoog qis dua 18 xyoo
daim siab mob
mob raum
cov mob qog
tus neeg tsis kam txais.

Statins thiab lawv hom

Lawv tau faib raws li cov tshuaj nquag uas cuam tshuam rau kev tsim cov roj (cholesterol). Hauv cov thawj-xyoo statins, cov khoom no yog lovastatin. Tom qab, cov tshuaj tau tshwm sim nrog fluvastafin, simvastain thiab pravastain. Cov tshuaj tshiab uas muaj rosuvastatin thiab atorvastatin muaj cov txiaj ntsig zoo dua, txo LDL hauv cov ntshav thiab nce cov roj (cholesterol) zoo. Yog tias cov tshuaj nrog lovastine txo LDL los ntawm 25%, tom qab ntawd ib tiam tshiab ntawm cov ntsiav tshuaj nrog rosuvastine - los ntawm 55%.

Statins yog cov tshuaj hauv qab no:

Peb cov neeg nyeem tau siv Aterol ua tiav kom qis cov roj (cholesterol). Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

nrog lovastatin - “Choletar”, “Cardiostatin”,
nrog simvastatin - “Vasilip”, “Ariescore”, “Txhaum”, “Simvastol”, “Zokor”,
nrog fluvastatin - “Leskol Forte”,
nrog atorvastatin - “Tulip”, “Liptonorm”, “Atoris”, “Liprimar”, “Canon”, “Liprimar”,
nrog rosuvastatin - "Roxer", "Mertenil", "Tavastor", "Crestor", "Rosulip".

Dab tsi koj yuav tsum paub txog statins?

Lawv coj mus ntev nrog kev saib xyuas ntawm tus kws kho mob.
Cholesterol yog tsim nyob rau yav hmo ntuj, yog li koj yuav tsum coj pab pawg no ntawm cov tshuaj nyob rau yav tsaus ntuj.
Yog tias koj muaj leeg tsis muaj zog thiab mob, koj yuav tsum sab laj nrog koj tus kws kho mob sai.
Nrog kev ceev faj, lawv tau kho rau cov neeg kev txom nyem los ntawm kev coj khaub ncaws txhua ntu.
Cov poj niam uas muaj hnub nyoog deev yuav tsum siv tshuaj tiv thaiv thaum noj cov tshuaj statins.
Thaum kho, tswj cov ntshav yuav tsum tau ua los ntsuas qhov ua tau ntawm kev kho mob thiab txhawm rau txhawm rau paub txog kev phiv los ntawm cov tshuaj.

Lwm pawg ntawm cov tshuaj uas txo cov roj cholesterol yog iv derivatives ntawm fibroic acid. Cov tshuaj no tsis tiv thaiv LDL dua li cov tshuaj statins. Lawv nce HDL thiab qib qis ntawm cov rog nruab nrab, lossis triglycerides. Feem ntau, cov roj (cholesterol) tau raug txo los ntawm 15%, thaum lub sijhawm ua haujlwm rau lub ntsa voos muaj zog.

Cov tshuaj hauv qab no zwm rau hauv pab pawg no:

Cov kev phiv nrog:

daim tawv nqaij ua pob
kev cuam tshuam ntawm txoj hnyuv,
mob hlwb
ua xua
kev loj hlob ntawm pancreatitis,
nce qib ntawm daim siab enzymes,
kev tsim cov tshuaj thrombosis.

Xaus

Cov kev daws rau cov roj (cholesterol) siab muaj ntau qhov tshwm sim uas tuaj yeem cuam tshuam loj rau kev noj qab haus huv nrog kev siv ntev. Cov kws kho mob tsis pom zoo txog kev teem caij noj cov tshuaj no. Cov txiv neej hluas (hnub nyoog qis dua 35 xyoos) thiab cov poj niam muaj hnub nyoog kev ua me nyuam uas tsis muaj kev cuam tshuam cov kab mob hlab plawv tau qhia kom txo qis cov roj (cholesterol) yam tsis muaj kev noj tshuaj, uas yog, kho lawv cov zaub mov noj thiab kev ua neej. Txawm li cas los xij, cov ntsiav tshuaj tsis tuaj yeem niaj zaus nrog. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias lawv yuav tsum tau noj tsuas yog qhia los ntawm kws kho mob. Ntxiv nrog rau kev noj tshuaj, koj yuav tsum hloov koj txoj kev ua neej, uas yog, ua raws li kev noj zaub mov zoo, tawm dag zog, tsis suav nrog kev haus luam yeeb.

Rosuvastatin - kev qhia rau siv

Dab tsi yog rosuvastatin tshuaj rau? Daim ntawv teev cov kab mob thiab mob yog qhov tsawg:

Hypercholesterolemia (hom IIa, suav nrog tsev neeg heterozygous hypercholesterolemia) los yog sib xyaw hypercholesterolemia (hom IIb) raws li kev ntxiv rau kev noj zaub mov,
Tsev neeg homozygous hypercholesterolemia yog qhov ntxiv rau cov zaub mov noj,
Mob Hlwb Pob Txha, mob hlwb los yog mob raum atherosclerosis, occlusive leeg lumen,
Atherosclerosis ntawm cov hlab ntshav ntawm qhov qis qis, suav nrog Lerish's syndrome, kub siab, nrog rau qib C-reactive protein ntau hauv tsev neeg keeb kwm,
Hypertriglyceridemia (hom IV raws li Fredrickson),
Kev kho mob ntawm myocardial infarction thiab hlwb, pib txij li lub sijhawm mob,
Kev tiv thaiv ntawm myocardial infarction thiab mob stroke.

Raws li koj tuaj yeem pom, koj yuav tsum tsis txhob kho Rosuvastatin ua cov roj (cholesterol) uas koj tuaj yeem siv ntawm koj tus kheej.

Kev noj tshuaj ntau ntxiv - yuav ua li cas noj rosuvastatin?

Rosuvastatin ntsiav tshuaj noj ntawm qhov ncauj nrog dej. Qhov pom zoo kom pib noj rau cov neeg laus yog 1 ntsiav tshuaj ntawm rosuvastatin 10 - 1 zaug ib hnub.

Raws li cov txiaj ntsig ntawm kev tsom xam, kev noj tshuaj tuaj yeem nce ntxiv rau 20 mg tom qab 4 lub lis piam (tsis yog dhau los).

Kev nce ntxiv rau 40 mg ntawm rosuvastatin tsuas yog ua tau rau cov neeg mob hypercholesterolemia thiab muaj kev pheej hmoo siab ntawm cov hlab plawv mob hnyav (tshwj xeeb tshaj yog nyob rau cov neeg mob nrog tsev neeg hypercholesterolemia) nrog kev kho mob me me ntawm ib koob tshuaj 20 mg, thiab raug tshuaj xyuas mob.

Kev tiv thaiv ntawm pathologies ntawm CCC
Hauv kev tshawb fawb ntawm cov tshuaj tiv thaiv rosuvastatin, ib koob tshuaj 20 mg / hnub tau siv. Nws yuav tsum raug coj mus rau hauv tus account - qhov pib noj tshuaj yuav tsum tsawg dua thiab tau coj los noj rau hauv tus neeg mob qhov ntsuas ntawm 5 txog 10 mg / hnub.

Nta

Rau cov neeg mob txij li 70 xyoo ntawm lub hnub nyoog, kev kho mob nrog rosuvastatin yog kho nyob rau hauv ib qho kev pib ntawm 5 mg / hnub. Qhov kev hloov pauv tshuaj yog nqa los ntawm tus kws kho mob, yog tias tsim nyog, coj mus rau hauv tus lej ntawm cov roj cholesterol thiab qhov muaj feem yuav muaj kab mob ntawm cov hlab plawv.

Thaum siv rosuvastatin hauv ib koob ntawm 40 mg, nws raug nquahu kom soj ntsuam cov cim ua haujlwm raum. Ntxiv contraindications rau rosuvastatin yog ua tau.
Feem ntau, cov proteinuria txo qis lossis ploj mus thaum kho mob thiab tsis txhais tau tias qhov tshwm sim ntawm cov mob hnyav los yog kev kho mob ntawm lub raum mob uas twb muaj lawm.

Hauv cov neeg mob hypercholesterolemia vim yog hypothyroidism lossis nephrotic syndrome, txoj kev kho ntawm cov kab mob tseem ceeb yuav tsum tau nqa tawm ua ntej kev kho mob nrog rosuvastatin.

Tag nrho cov kev ntsuam xyuas: 27 Sau kev ntsuam xyuas

Kuv muaj 6,17 cov roj (cholesterol) - Kuv tau xaj cov tshuaj rosuvastatin no, tab sis raws li kuv nyeem cov lus qhia, muaj cov lus sib lwv sib luag uas nws tseem txaus ntshai pib noj. Tej zaum nws ntxov kuv yuav tau txais cov tshuaj nrog rau cov cholesterol no.

Elena, sim noj cov zaub mov ua ntej, yog tias koj tsis tau sim nws tsis tau. Noj cov zaub ntsuab ntau dua ... Satin yog qhov chaw kawg.

txoj kev zoo tshaj coj ??

Noj raws li sau rau hauv cov lus qhia rau kev siv, lossis raws li qhia los ntawm tus kws kho mob uas sau ntawv rosuvastatin.

Tsis ntev los no Rosuvastatin tau pib sau ntawv los ntawm tus kws kho mob. Cov ntawv xeem yuav sai sai no qhia nws cov haujlwm, tab sis nyob rau hauv kev pom zoo ntawm Rosuvastatin Kuv xav hais tias nws tsis muaj cov tsos mob phem ntawd, zoo li los ntawm qee lwm yam tshuaj.

Muaj cov xim hlau tsw qab hauv qhov ncauj thiab goosebumps, txawm hais tias 10mg koob tshuaj yog ib qho tshuaj mob uas txaus ntshai heev thiab kim.

Kuv coj rosuvastatin-s3 40 mg ib xyoo dhau los (tus kws kho mob sau) muaj cov roj (cholesterol) siab heev, ib hlis tom qab nws hloov cev. Nws tsim nyog yuav tau txhaj koob tshuaj tsawg dua.

Kuv tseem coj rosuvastatin-sz, ntawm kev noj tshuaj ntawm 10 mg, thiab nws kuj tau txhawj xeeb txog kev phiv - Kuv tseem tsis muaj teeb meem txaus rau daim siab kom tau txais cov roj (cholesterol) siab, tab sis kuv txhawj xeeb hauv qhov tsis muaj txiaj ntsig - Kuv zoo siab, kuv cov roj cholesterol tsawg dua.

Thaum koj pom tias cov lus qhia muaj ntau cov kev mob tshwm sim, qhov no qhia tau hais tias cov tshuaj tau kawm hauv kev nthuav dav thiab ua tib zoo tshawb nrhiav cov kev tshawb fawb tau ua. Tsis txhob xav tias kev yuav lwm cov tshuaj "txuj ci tseem ceeb" nrog cov lus qhia luv luv thiab qhov taw qhia "rau txhua yam mob" yuav muaj tseeb. Kev lag luam tshuaj yog ib qho loj tshaj plaws hauv ntiaj teb thiab xav tau "nce qib". Kuv zoo dua ntawm kev yuav ib lub hauv tsev, qhov tseeb, thiab qhov tseem ceeb tshaj plaws, tus kws kho mob tau xaiv los ntawm Rozuvastatin-SZ, uas kuv tau ua rau 7 lub hlis dhau los. Raws li qhov tshwm sim, cov roj (cholesterol) poob qis los ntawm 6.9 mus rau 5.3. Tsuas yog tsis txhob tus kheej noj tshuaj - ua ntej rau tus kws kho mob!

Rosuvastatin yog qhov tsim nyog rau cov roj (cholesterol) siab, tab sis yog tias hypercholesterolemia muaj mob pes nrab, koj tuaj yeem yooj yim los ntawm kev noj zaub mov thiab dibicor, yog li zam qhov ntev thiab tsis muaj kev nyab xeeb ntawm statin ntawm lub cev.

Rosuvatin-sz (zoo li hauv daim duab) yog qhov pheej yig tshaj plaws ntawm txhua qhov statins. Kuv paub meej tias - nws ua haujlwm. Ntawm kev phiv - kiv taub hau nyob rau hauv thawj hnub ntawm kev nkag, ces txhua yam ploj mus. Cholesterol los ntawm 7.5 mus rau 5.3 nyob rau hauv 1.5 lub hlis.

Kuv niam pog haus rosuvastatin sz, thiab kuv niam tau sau ntawv rau atorvastatin sz, nws tsis ntshai haus, vim tias yog tias koj tsis haus dej, txhua yam tuaj yeem ua rau tsis zoo. Los ntawm txoj kev, cov tshuaj tsis kim.

Ib qho tshuaj zoo heev, rosuvastatin-sz, Kuv pom tseeb los ntawm tus kheej piv txwv - thaum lub hli siv, cov roj (cholesterol) poob los ntawm 8.8 rau 5.1, thiab qhov no yog qhov tsis tau noj zaub mov (Kuv hloov siab lees txim, Kuv tsis tuaj yeem ua raws). Kuv feem ntau tau txais lub tswv yim hais tias txawv teb chaws cov neeg zoo dua, Kuv tsis yog ib tug super-patriot yog, tab sis nws zoo nkaus li peb cov tshuaj tseem muaj peev xwm ua tau, tsawg kawg tsis yog qhov nyuaj

Kuv tau noj atorvastatin-sz tau ntev, qhov ntau npaum li cas tsis yog, tab sis nws tsis tso cai rau cov roj (cholesterol) nce rau cov lej phom sij.

Kuv pom zoo rau kev tshuaj xyuas zoo txog rosuvastatin-sz! Kuv tau tawm tsam nrog cov roj hauv tsib xyoos, Kuv tau sim ntau yam - ob qho txawv teb thiab peb li. Tam sim no, tau kawg, cov tsis tuaj yeem tuaj yeem tsis tuaj yeem txhua, tsuas yog rosuvastatin-sz mus tau zoo los ntawm cov khoom hauv tsev, thiab tseem ceeb tshaj, feem ntau yog nyob hauv cov chaw muag tshuaj

Thaum muaj hnub nyoog 33, ntawm kev kuaj mob, nws tau pom tawm txhij txhua txog kev cia siab tias cov roj (cholesterol) tau nce siab! Tshaj tag nrho 8.1, tsis zoo - 6.7! Tus naj npawb txaus siab. Kuv pib noj rosuvastatin-sz, Kuv ntshai heev uas yuav muaj kev rau txim. Hauv kuv kev paub, cov tshuaj yeej ib txwm, qhov tseem ceeb tshaj plaws yog cov roj (cholesterol) qis.

Kuv tau noj rosuvastatin-sz tau 3 xyoos. Tom qab lub plawv nres, lawv tau raug xaiv los ua neej. Tsis muaj kev mob tshwm sim, tsuas yog thaum thawj zaug muaj kiv taub hau me ntsis, cov roj (cholesterol) nyob ntev li 4.5-4.8. Txaus siab nrog tus nqi.

Ib cov tshuaj zoo yog rosuvastatin. Kuv tau xaj rosuvastatin-sz, nws pheej yig dua li lwm qhov, tab sis kuv tuaj yeem hais tias kuv tau haus nws rau lub hlis thib peb thiab kuv tau hnov zoo. Tsis muaj kev mob tshwm sim, txawm hais tias kuv yuav qhia koj zaj dab neeg txaus ntshai. Cov Cholesterol poob los ntawm 8.5 rau 4.3.

Nws pib noj rosuvastatin-sz tom qab ob chav kawm ntawm atorvastatin - tus kws kho mob tau hais kom hloov mus rau ib hom tshuaj tshiab dua. Cov roj khov ua kom zoo yog qhov tseeb. Kuv tsis tau soj ntsuam phiv. Txaus siab nrog tus nqi.

Kuv tseem tuaj yeem qhuas rosuvastatin-sz, ntxiv rau cov lus tshaj tawm saum toj no - Kuv raug tshwj xeeb los ntawm tus nqi, tau kawg Kuv tsis tau pom qhov txawv nrog lwm cov tshuaj, thiab cov neeg Lav Xias txais thiab coj mus muag, lawv txhua tus ua haujlwm zoo ib yam. Yog li, koj tuaj yeem xaiv ntawm tus nqi.

Muaj cov txheej txheem pej xeem, tab sis lawv cia li tsis ua haujlwm. Peb lub cev tsim cov roj (cholesterol), lossis feem ntau ntawm nws. Koj tuaj yeem txo nws nrog statins, piv txwv li, tib yam rosuvastatin-sz, uas tau piav qhia saum toj no. Lub hauv paus ntsiab lus ntawm kev nqis tes ua - cov tshuaj txwv cov khoom tsim los ntawm cov roj (cholesterol) hauv lub siab (qhov no yog qhov kev piav qhia heev, nyeem cov xaib profile). Tsis txhob tsis saib xyuas kws kho mob txhua lub sijhawm, tsuas yog lawv yuav xaiv cov kev kho kom zoo.

Dab tsi ua kom yooj yim rau noj cov tshuaj statins yog tias tsuas muaj ib ntsiav tshuaj ib hnub. Kuv tsis paub tseeb tias koj puas muaj rog txog 7 nws yog qhov tsim nyog, tab sis yog tias nws siab dua, ces nws tsim nyog yuav tsum tau ua. Atherosclerosis, mob hlab ntsha hlwb thiab lub plawv nres yog qhov ntau dua li qhov kev ntshai ntawm kev xav tshwm sim ntawm daim siab thiab lub raum. Los ntawm txoj kev, tom qab lub plawv nres, statins yog tshuaj rau lub neej thiab tsis muaj dab tsi, tib neeg nyob kaj siab lug puas tau tom qab. Kuv tus kheej tawm tsam cov tshuaj muaj nqi ntau, yog tias muaj pheej yig, thiab cov tshuaj tiv thaiv kab mob hauv tsev, yog li yog tias koj tau txais tshuaj statins, sim nug koj tus kws kho mob txog rosuvastatin-sz. Thiab tom qab ntawd ntau yam crosses thiab tevastors raug xaiv ntawm ob peb txhiab rau pob, tab sis muaj tib yam ntawm 400 rubles.

Qhia rau kuv, dab tsi yog kev cai hauv cov ntshav cov roj hauv cov neeg laus, kwv yees li 67 xyoo? Liam, qhov kev cai yog 3.5)

Hauv lub hnub nyoog no, cov cai no raug txiav txim siab los ntawm 4.4 txog 7.8. Tab sis nws yog qhov zoo dua los ua kom cov roj (cholesterol) hauv nws cov kab hauv qab qis dua. Piv txwv li, hauv 30 xyoos cov laus, cov cai yog los ntawm 3.3 txog 5.9. Yog tias cov roj (cholesterol) siab dua, cov tshuaj tua kab mob yeej nyob hauv. Piv txwv li, tib yam rosuvastatin-sz txog qhov lawv tau sau saum toj no.

Kuv noj ib qho tshuaj analogue, rosuvastatin-sz hauv ib qhov tshuaj ntawm 40 mg, yog li nws hloov tawm tsuas noj ib ntsiav tshuaj ib hnub, uas yooj yim heev. Ntawm tus nqi ntau dua qis dua rosuvastatin txawv teb.

Rau lub hlis tom qab lawv tau ua txoj kev phais bypass, lawv pom cov plaques hauv ob lub nkoj ntxiv. Rosuvastatin noj tag nrho lub sijhawm no 20 mg. Ua ntej, kho lub siab thiab lub raum, nraub qaum, hauv siab cov leeg, tej zaum yog noj ntau dua? Thiab qhia rau kuv, tsawg kawg ib tug neeg raug kho cov quav hniav qee zaum nrog cov tshuaj no .... Cov. thiab tom qab ntau npaum li cas?

Kuv tau noj rosuvastatin tau ntev, ntev txog 4 xyoos. Kuv tsis yws txog cov roj (cholesterol) 5.9-6.2 tsis nce siab saum toj saud, lub siab poob qis, nws siv tau 160-170, tam sim no 130-140. Hauv thawj lub hlis, cov nyhuv tshwj xeeb tshaj yog pom txij li txog siav ua tsis taus pa tawm ntawm lub dag lub zog thiab kiv taub hau nrog txhua lub lim tiam tau tsawg zuj zus. Tom ntej no, tsuas yog txhua txhua rau lub hlis, tswj xyuas ntshav.

Cov lus qhia rau kev siv rosuvastatin

Cov tshuaj Rosuvastatin (Rosuvastatin) muaj lipid-txo cov nyhuv, muaj cov tshuaj qub qub. Cov tshuaj yog tsim los ntawm ntau lub tuam txhab - Lavxias teb sab Canon thiab North Star, Israeli Teva. Kev siv cov tshuaj tsuas yog txiav txim siab nrog ib qib ntxiv ntawm lipids thiab cov cholesterol nyob rau hauv cov ntshav. Cov cuab yeej ua haujlwm normalizes cov tshuaj ntawm cov tshuaj no, ua kom tib neeg kev noj qab haus huv.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Rosuvastatin tsuas yog muaj nyob hauv ntsiav tshuaj hom ntawv; tsis muaj lwm daim ntawv tso tawm. Cov yam ntxwv ntawm muaj pes tsawg leeg:

Hloov lub teeb paj yeeb dawb sab hauv dawb

Qhov concentration ntawm rosuvastatin nyob rau hauv daim ntawv ntawm calcium calcium, mg rau ib pc.

Cov xim liab carmine, microcrystalline cellulose, triacetin, pregelatinized hmoov txhuv nplej siab, magnesium stearate, titanium dioxide, colloidal silicon dioxide, hypromellose, lactose monohydrate

Pob ntawm 10 pcs., 3 lossis 6 rau ib pob

Pharmacodynamics thiab pharmacokinetics

Cov lipid-txo qis tshuaj Rosuvastatin yog ib qho kev xaiv qhov kev cuam tshuam ntawm cov enzyme gamma-glutamyltranspeptidase, uas txhawb nqa cov tsos ntawm mevalonate, lub zog ua ntej ntawm cov roj (cholesterol). Cov tshuaj nquag ntawm cov tshuaj ua haujlwm hauv lub siab, muaj kev sib cais ntawm cov roj (cholesterol) thiab catabolism ntawm lipoproteins ntawm qhov ceev. Cov tshuaj tsub kom tus naj npawb ntawm receptors rau yav tas los nyob rau saum npoo ntawm lub siab hlwb, ua rau lawv nce thiab catabolism, uas inhibits cov synthesis ntawm lipoproteins ntau tsawg heev.

Ib zaug hauv cov ntshav, lub inhibitor thiab efflux transporter Rosuvastatin nce mus txog qhov siab tshaj plaws tom qab tsib teev. Nws cov metabolism nrog kev koom tes ntawm cytochrome isoenzymes tshwm sim hauv lub siab, nws khi rau albumin los ntawm 90%. Tom qab kev tshem tawm, metabolites raug tsim nyob rau hauv daim siab uas ua haujlwm tsawg, tsis txhob cuam tshuam qhov thauj ntawm cov organic anions thiab polypeptides, kev tshem tawm ntawm creatinine thiab creatine phosphokinase, cov roj cholesterol biosynthesis.

Yuav luag tag nrho cov tshuaj ntawm cov tshuaj tawm txoj hnyuv tsis hloov, qhov seem - nrog rau ob lub raum thiab zis. Ib nrab-lub neej yog 19 teev. Cov pharmacokinetics ntawm cov tshuaj nquag ntawm cov muaj pes tsawg leeg tsis cuam tshuam los ntawm poj niam txiv neej, hnub nyoog, tab sis muaj qhov sib txawv kom ncav cuag qhov kev xav ntau tshaj plaws hauv cov neeg sawv cev ntawm lwm haiv neeg (ntau dua ob zaug hauv Mongoloids thiab Indians dua hauv Caucasians thiab Negroids).

Cov tshuaj nquag ntawm rosuvastatin

Cov nquag ua haujlwm ntawm cov tshuaj tiv thaiv inhibitor txo qhov nce siab ntawm cov roj cholesterol, triglycerides, lipoproteins tsawg ntom, apolipoprotein, ua rau cov lipoproteins ntau ntom tsawg. Raws li qhov tshwm sim, hauv cov neeg mob hypercholesterolemia, lipid profile txhim kho thiab atherogenicity index poob qis. Kev kho mob nyhuv ntawm cov tshuaj tshwm sim nyob rau hauv ib lub lis piam, mus txog qhov siab kawg los ntawm lub hli ntawm kev kho. Cov tshuaj tau qhia rau cov neeg laus uas muaj hypercholesterolemia nrog lossis tsis triglyceridemia, nrog cov nyiam ua rau mob stroke lossis lub plawv nres.

Kev ntsuas rau siv

Lub hauv paus tseem ceeb rau kev siv cov tshuaj Rosuvastatin yog cov kab mob cuam tshuam nrog kev nce qib lipid. Kev Taw Qhia:

thawj hypercholesterolemia, suav nrog hom tsev neeg heterozygous, los yog sib xyaw hypercholesterolemia nrog kev noj zaub mov zoo, kev tawm dag zog,
tsev neeg homozygous hypercholesterolemia txuam nrog kev noj zaub mov noj thiab kev kho lipid,
hypertriglyceridemia,
maj mam muaj mob ntawm atherosclerosis,
kev tiv thaiv ua ntej ntawm mob stroke, mob plawv nres, mob ntshav thim rov qab los tsis muaj cov cim kev mob plawv, tab sis nrog kev pheej hmoo ntawm nws txoj kev loj hlob (hnub nyoog muaj hnub nyoog, mob ntshav siab, haus luam yeeb, tsev neeg keeb kwm).

Yuav ua li cas noj rosuvastatin

Cov ntsiav tshuaj tau noj ntawm qhov ncauj, ntxuav nrog dej. Lawv tsis tuaj yeem raug zom lossis tsoo. Cov tshuaj raug coj mus nyob rau txhua lub sijhawm thaum nruab hnub, tsis muaj daim ntawv ntim zaub mov. Ua ntej pib kev kho mob, tus neeg mob yuav tsum ua raws li kev noj zaub mov nrog kev txwv cov zaub mov uas muaj cov rog. Thawj koob tshuaj rau cov neeg mob yog 5 lossis 10 mg ntawm rosuvastatin ib zaug / hnub. Tom qab 4 lub lis piam, cov koob tshuaj yuav tau nce ntxiv.

Ib koob tshuaj 40 mg ntawm rosuvastatin yog kho nrog ceev faj, yuav tsum tau saib xyuas tshwj xeeb rau cov neeg mob ntawd. Txhua 2-4 lub lim tiam ntawm txoj kev kho, cov neeg mob pub ntshav los txiav txim lipid tsis muaj. Rau cov neeg mob laus, cov koob tshuaj tsis tau hloov kho, nrog lub raum tsis ua haujlwm, noj tshuaj yog contraindicated. Rau cov mob nyhav hepatic, qhov koob tshuaj yuav tsis dhau 5 mg.

Cov lus qhia tshwj xeeb

Rosuvastatin cuam tshuam cuam tshuam rau kev ua haujlwm ntawm lub siab thiab lub raum, lwm qhov kev siv lub cev, yog li nws txoj kev kho yog nrog cov lus qhia tshwj xeeb. Cov cai tswj kev noj tshuaj:

Kev txhaj tshuaj ntau ntawm cov tshuaj tuaj yeem ua rau tubular proteinuria hloov chaw. Thaum kho, kev ua haujlwm ntawm lub raum yuav tsum tau saib xyuas.
Cov koob tshuaj ntau tshaj 20 mg / hnub tuaj yeem ua rau myalgia, myopathy, rhabdomyolysis, thiab lwm yam kev tsis sib haum xeeb hauv kev ua haujlwm ntawm cov leeg hlwb. Yog tias cov neeg mob tau muaj kev pheej hmoo txaus rau kev txhim kho ntawm cov pathologies, cov tshuaj yog kho nrog ceev faj.
Yog tias thaum kho tus neeg mob tam sim ntawd muaj mob nqaij, tsis muaj zog los yog mob plab vim muaj qhov ua tsis taus pa lossis kub ib ce, yuav tsum tau mus ntsib kws kho mob sai. Cov kab mob hauv lub cev tiv thaiv kab mob myopathy (cov leeg tsis muaj zog, ua kom muaj enzyme ntau ntxiv) tsis tshua muaj tshwm sim. Txhawm rau tshem tawm cov paib tsis zoo tom qab kev soj ntsuam dhau los, kev siv tshuaj tiv thaiv kab mob kev nkeeg yog nqa tawm.
Noj rosuvastatin ntsiav tshuaj tsis muaj kev cuam tshuam qhov nce ntawm kev cuam tshuam ntawm cov leeg pob txha.
Yog hais tias hypercholesterolemia tshwm sim los ntawm hypothyroidism lossis nephrotic syndrome, koj yuav tsum xub tshem tawm cov kab mob hauv qab, thiab tom qab ntawd noj Rosuvastatin.
Cov tshuaj yog tso tseg nrog qhov nce ntxiv ntawm cov kev ua ntawm hepatic transaminases peb zaug.
Cov tshuaj muaj lactose, yog li ntawd nws txoj kev tswj hwm yog contraindicated nyob rau hauv rooj plaub ntawm lactose intolerance, lactase deficiency, qabzib-galactose malabsorption.
Kev siv tshuaj statin ntev ntev tuaj yeem ua rau mob ntsws interstitial ntsws, uas pom los ntawm kev ua pa luv, hnoos, tsis muaj zog, poob ceeb thawj, thiab kub cev. Yog tias cov tsos mob no tau pom, txoj kev kho tau tso tseg.
Thaum kho nrog tshuaj, kiv taub hau thiab qaug zog yuav tshwm sim, yog li ntawd, nws raug nquahu kom tsis txhob tswj cov txheej txheem thiab tsheb.
Thaum sau ntawv yuav tshuaj, tshuaj tiv thaiv kab mob polymorphism yuav tsum tau txiav txim siab.

Thaum cev xeeb tub

Kev siv cov rosuvastatin yog contraindicated hauv kev xeeb tub. Yog tias tus poj niam thaum muaj hnub nyoog yug me nyuam noj cov tshuaj, ces nws yuav tsum siv txoj kev tiv thaiv kom tsis pub muaj menyuam. Thaum kuaj pom lub cev xeeb tub, cov tshuaj yuav tsum tau tsum tsis ua sai sai.Tsis paub tseeb tias cov tshuaj ua kom muaj zog hauv niam cov kua mis, tab sis kev siv cov ntsiav tshuaj tshem tawm rau lub sijhawm pub mis niam (lactation).

Hauv thaum yau

Kev siv cov tshuaj rosuvastatin rau cov menyuam yaus thiab cov tub ntxhais hluas uas muaj hnub nyoog qis dua 18 xyoo yog qhov tsis pom zoo. Xws li qhov txiav npluav yog cuam tshuam nrog kev ua haujlwm ntawm cov tshuaj nyob rau hauv lub siab, uas tuaj yeem ua rau tsis ua haujlwm lossis ua rau mob tsis ua haujlwm nyob hauv kev ua haujlwm ntawm cov khoom no lossis lub cev tag nrho. Kev teem cov tshuaj tom qab 18 xyoo yuav tsum tau ua ntej los ntawm kws kho mob qhov kev sab laj thiab kev soj ntsuam tag nrho.

Yog hais tias lub raum ua rau lub raum thiab lub cev tsis ua haujlwm

Cov neeg mob uas muaj lub raum ua rau lub siab tsis ua hauj lwm zoo lawm hauv kev muab tshuaj. Ib koob tshuaj txhua hnub ntawm 40 mg ntawm rosuvastatin raug txwv rau kev siv rau cov neeg mob uas mob raum tsis txaus, kev noj tshuaj 5, 10 thiab 20 mg yog siv nrog kev ceev faj. Thaum lub raum ua kom tsis muaj zog, yuav tsum ceev faj nrog 40 mg ntawm cov tshuaj.

Yeeb tshuaj sib cuam tshuam

Rosuvastatin yog tus cwj pwm los ntawm tus cwj pwm nquag ua haujlwm ntawm lwm cov tshuaj. Muaj cov kev sib txuas ua ke thiab cov kev sib txuam:

Kev sib xyaw ntawm cov tshuaj nrog Cyclosporine, protease inhibitors ntawm tib neeg cov tshuaj tiv thaiv kab mob (HIV), fibrates hauv ib koob ntawm 40 mg, inducers ntawm cytochrome substrate yog txwv tsis pub.
5 mg tshuaj sib xyaw nrog gemfibrozil, cov kab mob hypolipidemic, fenofibrate, nicotinic acid, fluconazole, digoxin, tshuaj tua kab mob raug tso cai.
Ceev faj yog qhia kom sib xyaw rosuvastatin thiab ezetimibe.
Nruab nrab ntawm kev noj cov ntsiav tshuaj thiab ncua ntawm antacids raws li txhuas lossis magnesium hydroxide, ob teev yuav tsum dhau, txwv tsis pub cov txiaj ntsig ntawm yav dhau los yog ib nrab.
Kev sib xyaw ntawm cov tshuaj nrog erythromycin tsub kom lub siab ntawm rosuvastatin hauv cov ntshav cov ntshav los ntawm ib feem peb.
Kev sib xyaw ntawm cov tshuaj nrog fusidic acid tuaj yeem ua rau kev txhim kho ntawm rhabdomyolysis.
Qhov koob tshuaj ntawm Rosuvastatin raug kho thaum ua ke nrog Ritonavir, Atazanavir, Simeprevir, Lopinavir, Clopidogrel, Eltrombopag, Darunavir, Ketoconazole. Kev sib xyaw nrog Tipranavir, Dronedarone, Itraconazole, Fosamprenavir, Aleglitazar, Silimarin, Rifampicin, Baikalin xav tau kev ua zoo ib yam.
Cov tshuaj tsub kom muaj qhov zam ntxiv ntawm qhov ncauj tawm tsam raws li cov tshuaj hormones ethinyl estradiol thiab norgestrel.

10 lus

Txhawm rau kom tus kws kho plawv koom paub tseeb tias tus neeg mob tsis txhim kho tus mob plawv sai sai - mob ntshav siab, mob ntshav qab zib tsis txaus, mob ntshav qab zib tsis txaus, tus kws kho mob yuav tsum saib xyuas cov qib roj thiab "roj" phem, uas suav nrog LDL (lipoproteins uas tsis muaj ntau) ) Hauv qhov no nws tau pab los ntawm cov lus pom zoo hauv teb chaws, nrog rau cov lus pom zoo ntawm European Society of Cardiology.

Nws hais tias cov neeg mob uas muaj kev pheej hmoo loj ntawm kev tsim cov hlab plawv yuav tsum sib zog ua kom cov ntshav LDL tsawg dua 3 mmol ib litres (muaj kev pheej hmoo tsawg), tsawg dua 2.5 nrog qhov nruab nrab thiab qis dua 1.8 mmol / l nrog theem siab ntawm kev pheej hmoo (piv txwv, nyob rau hauv muaj lub plawv nres lossis mob stroke yav dhau los).

Yuav kom ua raws li cov lus pom zoo no hauv cov neeg mob laus (kev mob plawv hauv lub plawv, txawm hais tias "rov ua kom sai" txawm li cas los xij, yog cov kab mob pathology ntawm cov neeg laus), ntau qhov yuav tsum tau ua. Yog tias koj hloov pauv qhov tseem ceeb ntawm cov zaub mov thiab lub neej tseem yooj yim rau lub hnub nyoog hluas, tom qab ntawd cov neeg laus, feem ntau pw ua ke, nra hnyav dhau ntawm qhov hnyav thiab ntau yam kabmob (ntshav qab zib mellitus), nws nyuaj dua kom tau txais cov hom phiaj tseem ceeb. Thiab yog li ntawd, cov tshuaj uas ua rau cov metabolism hauv cov roj ntsha hauv cov neeg mob zoo li no yog lub hauv paus thiab lub pob zeb ntawm kev tiv thaiv ntawm vascular kev puas tsuaj thiab teeb meem.

Ntawm cov tshuaj no, cov statins uas tiv thaiv HMG - CoA - reductase enzyme yog suav tias yog cov thawj coj. Hauv peb lub caij nyoog muaj ntau yam, muaj ntau tiam neeg ntawm statins, thiab lawv cov hauj lwm tau hloov ntau yam. Yog li, simvastatin ("Vazilip") raug xa mus rau cov pheej yig tshaj plaws thawj cov tshuaj thawj zaug. Tus sawv cev ntawm lub cim thib ob yog fluvastatin (Leskol), ntawm lub thib peb - atorvastatin (Liprimar). Cov tshuaj siv tau zoo tshaj plaws thiab niaj hnub suav nrog rosuvastatin. Qhov kev kho no zwm rau cov tshuaj thib plaub tiam, thiab cov tshuaj ua ntej uas tau nkag hauv lub khw yog Crestor.

Tam sim no, hauv cov khw muag tshuaj Lavxias koj tuaj yeem yuav tsis tsuas yog thawj rosuvastatin, tab sis kuj tseem muaj ntau yam analogues - txog 10 yam tshuaj sib txawv, thiab yog tias koj suav cov hom tsis muaj npe generics (muaj cov npe lag luam), tom qab ntawd tus naj npawb ntawm cov tshuaj ntawm cov tshuaj no yuav dhau ntau ntawm ob peb kaum os. Kev ua lag luam tsuas xav tau qhov xav tau, thiab tsis muaj leej twg yuav tsim cov tshuaj uas tsis muaj txiaj ntsig. Dab tsi ua rau Rosuvastatin nthuav, thiab nws ua haujlwm li cas?

Tus txheej txheem ntawm kev ua ntawm rosuvastatin

thawj cov tshuaj thiab cov analogues

Raws li tau hais los saum no, tag nrho cov statins inhibit HMG - CoA - reductase, uas ua lub luag haujlwm tseem ceeb hauv kev sib txuas ntawm cov roj (cholesterol) thiab nws feem "tsis zoo". Tab sis cov molecule ntawm rosuvastatin tau hloov kho nyob rau hauv txoj kev uas nws yog tsawg soluble nyob rau hauv cov rog, thiab yog li ntawd muaj kev sib txuam ntau dua rau qhov xav kom muaj enzyme (4 npaug tshaj li qhov ntuj suav ntawm lub cev). Vim tias qhov no, qhov txuas ntawm rosuvastatin nrog rau tus neeg xav tau tshwm sim sai, tsis yooj yim thiab "tawm ntawm tig". Yog li ntawd, cov synthesis ntawm mevalonic acid, cov roj ua ntej, ua rau txo cov ntshav hauv lub siab.

Cov kab mob siab ua raws li qhov no nrog kev nce ntxiv ntawm cov receptors rau cov roj (cholesterol) ntawm cov roj ntsha ntawm daim nyias nyias, cov feem "phem" zoo dua yog qhov ua tau thiab tshem tawm cov ntshav.

Tom qab noj cov tshuaj, qhov siab tshaj plaws nyob rau hauv cov ntshav accumulates tom qab 5 - 5.5 teev tom qab siv ib zaug, thiab nrog kev siv lub sijhawm ntev, kev sib npaug siab zoo tshwm sim uas tshwm sim 4 teev tom qab siv. Qhov no yog qhov tseem ceeb, vim tias qhov kev ua ntau yam ntawm kev txais tos nyob ntawm nws. Raws li rau kev tawm ntawm lub cev, nws txoj kev ceev tsis nyob ntawm qhov koob tshuaj thiab siv sijhawm ntev - txog 20 teev.

Cov lus qhia rau kev siv thiab ntau npaum li cas

Tus thawj rosuvastatin, Krestor, txawm li cas los xij, zoo li txhua lwm yam statins, tsuas yog muaj hauv cov qauv ntsiav tshuaj xwb. Muaj koob tshuaj 10, 20 thiab 40 mg. Qee qhov generics muaj ntau qhov ntau dua qhov noj tshuaj. Yog li, "Mertenil" ua los ntawm "Gideon Richter", Hungary, muaj ib qho ntxiv "pib" koob tshuaj 5 mg.

Yooj yim, kev quav yeeb tshuaj thiab zaub mov tsis txuas nrog txhua txoj kev. Koj tuaj yeem noj Rosuvastatin rau ntawm lub plab khoob, thaum sijhawm los yog tom qab noj mov.

Raws li rau qhov ntau npaum - nws tau xaiv ib tus zuj zus, thiab lub hauv paus rau qhov nce ntxiv yog kev kawm tshawb xyuas txog theem ntawm cov ntshav lipids, nrog cov ncauj lus kom ntxaws. Kev tshawb nrhiav uas tsuas yog ib lub ntsiab lus - tag nrho cov roj (cholesterol) - yog qhov ua tsis tau zoo.

Thawj zaug tshuaj ntawm rosuvastatin feem ntau yog 10 mg, qee zaum, muaj kev pheej hmoo siab tsawg thiab qhov tsis muaj mob rog hnyav, 5 mg tau sau tseg. Kev tsub ntxiv qhov tshuaj yog tso cai tsis pub ntxov tshaj ib hlis tom qab. Qhov siab tshaj plaws tau txhaj tshuaj yog 40 mg, thiab koj tuaj yeem tsa nws mus rau qhov ntsuas no tsuas yog siv raws cov kev taw qhia: kev mob siab ntsig ntshav hypercholesterolemia lossis muaj kev pheej hmoo siab heev. Nyob rau hauv tsis muaj qhov xwm txheej yuav tsum tau koj tam sim ntawd taw 40 mg rau tus neeg mob uas xub pib noj cov tshuaj statins. Tom qab 2 lub lis piam los yog lub hlis ntawm kev nkag mus, kev tswj xyuas ntshav lipids thiab cov ntsiab tseem ceeb hauv chaw kuaj mob thiab biochemical tau nqa tawm, thiab tus kws kho mob txiav txim siab ntxiv kev tawm tsam rau kev tswj hwm tus neeg mob.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Nrog cov tshuaj raug thiab tsim nyog ntawm cov tshuaj, thiab tshwj xeeb tshaj yog nrog lub hauv paus ntsiab lus ntawm cov tshuaj tiv thaiv kab mob nce ntxiv, rosuvastatin tau qhia nws txoj kev nyab xeeb hauv feem ntau ntawm cov neeg mob hauv kev xyaum ntawm tus kws kho mob. Ntawm chav kawm, qhov kev hais daws no tseem muaj nws cov contraindications thiab cov kev xav tsis zoo, uas yog koob tshuaj. Tab sis rosuvastatin muaj qhov peculiarity - tsis tsuas yog muaj kev phiv los yog koob tshuaj, tab sis kuj muaj contraindications. Rau cov neeg mob uas tuaj yeem noj 10 mg rau lub sijhawm ntev, nws tsis yog ib txwm ua tau kom nce lub koob tshuaj mus rau 20, thiab tseem ntau dua li 40 mg, piv txwv li, cov tshuaj hauv ib koob ntau dua 5 mg yog contraindicated rau:

cov neeg mob uas muaj kev hloov pauv hauv daim siab thiab nce qib ntawm transaminases (cholangitis, kab mob siab),
hauv kev mob raum tsis ua haujlwm (creatinine tshem tawm (CC) tsawg dua 30 ml ib feeb),
nrog myopathy,
yog tias tus neeg mob lees txais thiab tsis tuaj yeem thim tawm cyclosporine,
hauv cov poj niam cev xeeb tub, cov niam laus thiab menyuam yaus.

Kev siv 40 mg ntawm rosuvastatin yog contraindicated, ntxiv rau cov kab mob saum toj no, tseem ua haujlwm hauv qab no:

nrog lub raum tsis ua haujlwm nrog creatinine tshem tawm hauv qab no 60 ml ib feeb,
nyob rau hauv muaj myxedema thiab hypothyroidism,
nyob rau hauv muaj cov leeg mob hauv cov nqaij pob txha lossis hauv cov neeg txheeb ze (myasthenia gravis, myopathy),
haus cawv
Tus neeg mob Mongoloid (cov yam ntxwv hauv lub cev tsis zoo),
kev sib koom tes siv cov khoom siv fibrates.

Lawm, cov tshuaj yog contraindicated nyob rau hauv kev ua xua.

Ntawm kev mob tshwm sim, mob taub hau thiab mob nqaij, ua pob sawv pob, thiab ua kom cov leeg mob sawv cev ntau dua. Thaum ua cov kev ntsuas tswj hwm, cov theem ntawm transaminases qee zaum nce. Hauv cov neeg mob noj tshuaj thiab tsis yws ntawm cov leeg mob, nws yog qhov yuav tsum tau kuaj xyuas qib theem ntawm CPK (vim tias cov leeg lub cev tsis ua haujlwm lossis rhabdomyolysis ua tau).

Hauv cov lus qhia rau kev siv Rosuvastatin, seem ntawm cov cim tshwj xeeb thiab cuam tshuam nrog tshuaj uas yuav tsum tau txiav txim siab ua ntej pib kev kho yog piav qhia txhua yam.

Cov qauv qhia thiab cov generics ntawm Rosuvastatin

Tam sim no, ntau ntawm cov analogues ntawm tus thawj rosuvastatin tau tshwm sim ntawm tus nqi sib txawv, nrog kev txheeb xyuas sib txawv, tab sis nrog ib qho kev qhia rau kev siv. Thiab qhov no inevitably qhia tau qhov sib txawv zoo ntawm cov khoom uas siv. Tus thawj "Crestor" tuaj yeem muas tau ntawm "tus nqi tom": ntau npaum li cas ntawm 0.005 g Tsis tau. 28 tuaj yeem yuav rau 1299 rubles, thiab cov ntsiav tshuaj nrog qhov siab tshaj plaws ntawm 40 mg hauv tib tus nqi raug muag los ntawm 4475 rubles. Tab sis tus thawj coj yog ib pob ntawm 126 ntsiav tshuaj ntawm "Crestor" 10 mg txhua, nws tus nqi yog 8920 rubles. Hauv qhov no, tus nqi ntawm ib ntsiav tshuaj yog 70 rubles.

Ntau qhov zoo sib xws yog qhov pheej yig dua: canon rosuvastatin ntsiav tshuaj los ntawm Canonfarm Ntau lawm nrog lub Hoobkas hauv Schelkovo, Moscow Cheeb Tsam, tuaj yeem muas tau los ntawm 355 rubles. (10 mg No. 28). Ib hom lag luam zoo nkauj "Mertenil" los ntawm lub tuam txhab "Gedeon Richter" (Hungary) hauv qhov ntau npaum ntawm 20 mg, uas yog qhov nruab nrab, koj tuaj yeem yuav rau 800 rubles No. 30, thiab cov khoom ntim tau txaus rau ib hlis.

Qhov pheej yig tshaj plaws ntawm tus nqi kiag li, rosuvastatin (tsis hais ntau ntawm cov ntsiav tshuaj thiab ntau npaum li cas) yog muaj los ntawm FP Obolenskoye - 244 rubles rau ib pob ntawm 10 mg Tsis yog 28. Hauv lwm cov lus, tus nqi ntawm ib ntsiav tshuaj ntawm qhov pheej yig tshaj plaws yog 8,7 rubles, uas yog pheej yig dua. thawj cov ntsiav tshuaj ntau tshaj 8 zaug.

Hauv kev xaus, Kuv xav tau ib zaug ntxiv kom ua tib zoo saib xyuas kev mob siab rau cov neeg mob uas coj ib qho statin, lipid-txo cov zaub mov noj kom tsawg. Nws kuj tseem pom zoo kom poob ceeb thawj, kom tshem tawm cov kev coj ua tsis zoo, thiab thaum noj tshuaj - ua tib zoo soj ntsuam theem ntawm hepatic transaminases thiab ntsuas qhov ua tau zoo ntawm nthuav dav lipid spectrum.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj: biconvex, puag ncig, plhaub paj yeeb, qhov tseem ceeb ntawm qhov hla ntu yog yuav luag dawb lossis dawb (10 pcs. Hauv cov hlwv, hauv ib daim ntawv cardboard 3 lossis 6 pob, 14 pcs. Hauv blister sawb ntim, hauv duab los qhia qhov ntim 2 lossis 4 ntim, 30 pcs. hauv lub thawv ntim cov hlwv ntim, hauv ib pob ntawv qhwv 2, 3 lossis 4 pob, 20 lossis 90 pcs. thawv, txhua pob kuj muaj cov lus qhia rau kev siv Rose Vastatin-SZ).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: rosuvastatin (hauv daim ntawv ntawm rosuvastatin calcium) - 5, 10, 20 lossis 40 mg,
cov khoom siv ntxiv: calcium hydrogen phosphate dihydrate, lactose monohydrate (mis nyuj muaj suab thaj), povidone (tsis hnyav cov roj polyvinylpyrrolidone), sodium stearyl fumarate, croscarmellose sodium (primrose), microcrystalline cellulose, colloidal silicon dioxide (aerosil),
zaj duab xis txheej: Opadry II macrogol (polyethylene glycol) 3350, dej cawv polyvinyl, ib nrab hydrolyzed, titanium dioxide (E171), talc, kua lecithin (E322), kua roj vanish raws xim zas azorubine, txhuas cov kua roj vanish raws xim indigo carmine, txhuas kua roj vanish raws xim crimson (Ponceau 4R).

Sab sij huam

Thaum kho nrog cov tshuaj, cov kev mob tshwm sim me me, feem ntau ploj lawv tus kheej. Cov kev tsis zoo tshwm sim ntawm cov tshuaj Rosuvastatin yog:

mob ntshav qab zib mellitus
mob taub hau, kiv taub hau, tsis nco qab, mob puas siab ntsws neuropathy,
quav tawv, pancreatitis, xeev siab, mob plab, mob siab, raws plab,
mob caj dab, mob tso zis, pob khaus, Stevens-Johnson mob,
myalgia, rhabdomyolysis, mob myopathy, myositis, mob caj dab,
asthenic mob ntsws
o cov qog ntshav o
kev tiv thaiv kab mob
proteinuria, hematuria,
nce siab mob hepatic transaminases, qabzib, bilirubin (jaundice) ntau,
thrombocytopenia
hnoos, txog siav siav,
gynecomastia
peripheral edema,
kev nyuaj siab, insomnia, npau suav phem,
ua txhaum ntawm lub qog ua haujlwm lub qog ua haujlwm, kev ua haujlwm kev sib deev, lub plawv plawv,
muaj kev hemoglobin ntau ntxiv.

Noj ntau dhau

Yog tias koj noj tshuaj ntau ntau txhua hnub ntawm rosuvastatin tib lub sijhawm, cov pharmacokinetics yuav tsis hloov pauv. Cov tsos mob ntawm kev muaj peev xwm noj ntau dhau lawm yog qhov ua kom muaj kev cuam tshuam zoo. Tsis muaj cov tshuaj tua kab mob rau intoxication. Nws raug nquahu kom yoo lub plab, muab tshuaj kho mob nrog kev txhawb nqa ntawm daim siab thiab lwm yam kabmob tseem ceeb. Hemodilais tsis muaj kev ua haujlwm zoo.

Rosuvastatin analogs

Koj tuaj yeem hloov rosuvastatin ntsiav tshuaj nrog kev npaj muaj tib yam los yog sib npaug nrog cov tshuaj muaj zog. Cov analogues ntawm cov tshuaj muaj xws li:

Crestor - lipid-txo cov ntsiav tshuaj nrog tib yam sib xyaw ua ke,
Rosart - ntsiav tshuaj nrog lub zoo sib xws rau kev kho mob ntawm cov hlab plawv,
Roxer - ntsiav tshuaj los ntawm pab pawg neeg statins,
Tevastor - ntsiav tshuaj raws li cov tib cov tshuaj nquag, txo cov ntshav hauv cov ntshav.

Rosuvastatin thiab Atorvastatin - dab tsi yog qhov txawv

Cov analogue ntawm Rosuvastatin - Atorvastatin, suav nrog tib pawg tshuaj ntawm statins thiab muaj nyob rau hauv cov ntsiav tshuaj hom nrog lipid-txo cov cuab yeej. Tsis zoo li cov tshuaj hauv cov lus nug, atorvastatin muaj ntau cov rog hauv cov rog, thiab tsis yog ntshav ntshav lossis lwm yam kua, thiab yog li cuam tshuam rau cov qauv ntawm lub hlwb, thiab tsis nyob hauv daim siab mob hlwb (hepatocytes).

Cov tshuaj Rosuvastatin yog 10% zoo dua ntawm Atorvastatin, uas tso cai rau nws siv los kho mob rau cov neeg mob siab. Tsis tas li, tus neeg sawv cev hauv kev txiav txim siab tau txais txiaj ntsig zoo dua li kev thaiv cov leeg reductase hauv lub siab ua haujlwm thiab muaj cov nyhuv hais tawm. Kev phiv los ntawm cov tshuaj yog tib yam, yog li kev xaiv tshuaj muaj nyob ntawm tus kws kho mob.

Cov Tshuaj Pharmacokinetics

Qhov siab tshaj plaws ntawm rosuvastatin (C_max) hauv cov ntshav ntshav yog kwv yees li 5 teev tom qab kev tswj hwm ntawm qhov ncauj. Qhov tseeb txog txoj sia ntawm qhov tshuaj yog kwv yees li 20%, qhov ntim ntawm faib (V_d) - txog 134 litres. Rosuvastatin khi rau cov ntshav plasma protein, feem ntau nrog albumin, kwv yees li 90%. Raug rau ib qho zuj zus zuj zus (AUC) ntawm cov tshuaj yeeb dej caw nce nyob rau hauv ib feem ntawm qhov koob tshuaj. Nrog rau kev siv txhua hnub, cov yam ntxwv ntawm tus kws kho mob tsis hloov pauv.

Rosuvastatin yog metabolized feem ntau los ntawm lub siab - qhov chaw tseem ceeb ntawm cov roj (cholesterol) ntau lawm thiab kev hloov pauv hauv lub cev ntawm LDL-C.Nws yog metabolized rau qhov ntsuas me me (kwv yees li 10%), cov tshuaj nquag yog qhov tsis muaj tub ntxhais kawm sib txuas rau biotransformation los ntawm cov enzymes ntawm cytochrome P450 system. Lub ntsiab isoenzyme lub luag haujlwm rau cov metabolism hauv cov tshuaj yog isoenzyme CYP2C9, isoenzymes CYP2C19, CYP3A4 thiab CYP2D6 yog cov koom tes hauv cov metabolism hauv tsawg dua. Lub ntsiab tsim cov metabolites ntawm rosuvastatin yog lactone metabolites thiab N-desmethylrosuvastatin. Qhov tom kawg yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin. Lactone metabolites yog suav tias yog tsis muaj tshuaj pharmacologically. Tshaj 90% ntawm pharmacological kev ua ub no hauv kev tiv thaiv ncig ncig HMG-CoA reductase yog muab los ntawm rosuvastatin thiab 10% los ntawm nws cov metabolites.

Kwv yees li 90% ntawm cov koob tshuaj rosuvastatin raug ntog tawm los ntawm txoj hnyuv hauv daim ntawv tsis hloov pauv (suav nrog cov tshuaj tsis haum thiab tsis tuaj yeem), qhov seem yog tawm los ntawm lub raum. Ib nrab-lub neej (T_1/2) los ntawm ntshav ntshav yog kwv yees li 19 teev thiab tsis hloov nrog ua kom ntau dua. Qhov ntsuas duab ntawm cov ntshav ntawm lub plasma yog kwv yees li 50 l / h (coefficient ntawm variation 21.7%). Daim nyias nyias thauj cov roj (cholesterol), uas ua lub luag haujlwm tseem ceeb hauv cov txheej txheem hepatic tshem tawm cov khoom no, koom nrog hepatic uptake ntawm rosuvastatin.

Cov tshuaj pharmacokinetic ntawm rosuvastatin yog ywj siab ntawm tus pojniam thiab txivneej.

Rosuvastatin, zoo li lwm yam tshuaj tiv thaiv ntawm HMG-CoA reductase, khi rau thauj cov protein, xws li BCRP (efflux transporter) thiab OATP1B1 (ib qho polypeptide ntawm kev thauj cov organic anions koom nrog kev ntes cov statins los ntawm lub siab hlwb). Tus neeg nqa khoom ntawm genotypes ABCG2 (BCRP) s.421AA thiab SLC01B1 (OATP1B1) s.521CC pom qhov nce ntawm AUC ntawm rosuvastatin los ntawm 2.4 thiab 1.6 npaug, ntsig txog, piv nrog cov nqa khoom ntawm genotypes ABCG2 c.421CC thiab SLCO1B1 c.521TT.

Rosuvastatin-SZ, cov lus qhia rau kev siv: kev ua thiab qhov ntau npaum li cas

Rosuvastatin-SZ tau noj ntawm qhov ncauj. Cov ntsiav tshuaj, tsis txhob tsoo thiab ntxo, yuav tsum nqos tag nrho, ntxuav nrog dej.

Tus lipid-txo qis tus neeg sawv cev tuaj yeem siv tsis hais txog kev noj zaub mov thaum lub sijhawm nruab hnub.

Ua ntej pib ua haujlwm, tus neeg mob yuav tsum hloov mus rau kev noj zaub mov kom zoo nrog cov ntsiab lus ntawm cov roj cholesterol thiab tom qab ntawd ua raws nws thoob plaws hauv tag nrho lub sijhawm kho. Cov koob tshuaj yog xaiv tau ib tus zuj zus, coj mus rau hauv qhov kev saib xyuas tshuaj mus rau kev tswj hwm tshuaj thiab cov hom phiaj ntawm kev kho, nrog rau raws li cov lus pom zoo tam sim no ntawm cov qib lipid.

Rau cov neeg mob uas tsis tau ua yav tas los kho nrog statins, lossis tus uas tau noj lwm yam HMG-CoA reductase inhibitors ua ntej pib ua ntej, qhov kev pom zoo pib ntawm Rosuvastatin-SZ yog 5/10 mg ib hnub ib zaug. Thawj koob tshuaj yog tsim, coj los ntawm tus neeg lub siab ntawm cov roj (cholesterol) thiab coj mus rau hauv tus account qhov ntxim nyiam ntawm cov hlab plawv, nrog rau kev pheej hmoo ntawm kev tsis xav tau yam tsis xav tau. Yog tias tsim nyog, nce cov koob tshuaj tom qab 4 lub lis piam.

Vim tias qhov tshwm sim yuav tshwm sim ntawm cov kev mob tshwm sim thaum tswj hwm ntawm 40 mg / hnub, hauv kev sib piv nrog cov koob tshuaj qis dua txhua hnub, nws yog qhov ua tau kom nce qhov koob tshuaj rau 40 mg / hnub (tom qab ib qho kev noj ntxiv uas tau pom zoo tshaj li qhov xav tau thawj zaug rau 4 lub lim tiam) tsuas yog tias muaj mob hnyav cov neeg kawm tiav hypercholesterolemia thiab qhov kev pheej hmoo siab ntawm kev tsim kab mob plawv. Txog li 40 mg / hnub yog feem ntau tsuas yog kho rau cov neeg mob nrog tsev neeg hypercholesterolemia, uas tsis tuaj yeem ua tiav qhov xav tau kev kho mob nrog rau 20 mg / hnub, thiab leej twg yuav nyob hauv qab kev saib xyuas mob nkeeg nruj. Tshwj xeeb tshwj xeeb kev saib xyuas kev kho mob yog xav tau nyob rau hauv cov neeg mob tau txais kev noj tshuaj ib hnub ib zaug 40 mg ntawm Rosuvastatin-SZ.

Cov neeg mob uas tsis tau hu rau tus kws kho mob tshwj xeeb mas tsis pom zoo kom noj cov tshuaj Rosuvastatin-SZ 40 mg.

2-4 lub lis piam tom qab pib ua haujlwm ntawm kev kho thiab / lossis nrog kev nce ntxiv, kev saib xyuas cov lipid metabolism yuav tsum nqa tawm thiab, yog tias tsim nyog, cov koob tshuaj yuav tsum tau kho.

Nqa cov tshuaj genotypes c.421AA lossis s.521CC tsis pom zoo kom siv cov rosuvastatin-SZ hauv koob tshuaj ntau dua 20 mg ib hnub ib zaug.

Hauv cov txheej txheem ntawm kev kawm txog cov tshuaj pharmacokinetics ntawm rosuvastatin hauv cov neeg mob uas yog pawg neeg sib txawv, thaum noj cov tshuaj los ntawm cov neeg Nyij Pooj thiab Suav, ib qho kev nce ntxiv hauv cov kab ke ntawm rosuvastatin tau tshwm sim. Qhov tshwm sim no yuav tsum raug coj los txiav txim siab thaum muab tshuaj rau lipid-txo qis rau tus neeg sawv cev ntawm haiv neeg Mongoloid. Rau pawg no ntawm cov neeg mob uas tau txais kev kho mob ntawm kev noj tshuaj 10 thiab 20 mg, ib qho yuav tsum pib nrog kev noj tshuaj 5 mg / hnub, ntsiav tshuaj hauv qhov ntau npaum li 40 mg yog contraindicated.

Cov neeg mob uas nrog lub siab xav txog kev txhim kho myopathy Rosuvastatin-SZ raug pom zoo kom noj hauv thawj koob tshuaj 5 mg.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov kev tshawb fawb los kawm txog qhov ua tau ntawm Rosuvastatin-SZ ntawm kev muaj peev xwm tsav tsheb thiab siv cov txheej txheem nyuaj hauv kev ua haujlwm tsis tau ua. Thaum ua haujlwm cov kev phom sij txaus ntshai, cov neeg mob yuav tsum tau ceev faj, vim tias kiv taub hau yuav tshwm sim thaum kho.

Cev xeeb tub thiab lactation

Rosuvastatin-SZ yog contraindicated hauv kev xeeb tub thiab lactation. Cov poj niam ntawm lub hnub nyoog yug menyuam yuav tsum tau siv txoj kev tswj kom tsis muaj txiaj ntsig.

Txij li cov roj (cholesterol) thiab cov roj (cholesterol) biosynthesis tseem ceeb heev rau kev loj hlob ntawm tus menyuam, kev pheej hmoo ntawm kev noj qab haus huv HMG-CoA reductase zoo dua rau cov txiaj ntsig ntawm kev noj tshuaj Rosuvastatin-SZ hauv cov pojniam xeebtub. Thaum muaj cev xeeb tub thaum kho nrog tshuaj, nws cov neeg tswj hwm yuav tsum tau nres tam sim ntawd.

Tsis muaj ntaub ntawv hais txog kev faib rosuvastatin nrog rau niam mis, yog li ntawd, thaum lub sijhawm lactation, nws yog ib qho tsim nyog yuav tsum tsis txhob noj Rosuvastatin-SZ.

Nrog lub raum tsis ua haujlwm

Hauv cov neeg mob uas mob raum me lossis mob raum tsis ua haujlwm, tsis muaj kev hloov pauv tseem ceeb nyob hauv ntshav plos ntawm rosuvastatin lossis N-desmethylrosezuvastatin. Hauv kev mob tsis zoo rau lub raum, qib rosuvastatin nyob rau hauv cov ntshav ntshav yog 3 zaug, thiab N-desmethylrosuvastatin yog 9 zaug ntau dua li cov neeg ua haujlwm pab dawb noj qab haus huv. Lub plasma concentration ntawm rosuvastatin hauv cov neeg mob ua rau mob hemodialysis yog kwv yees li 50% siab dua hauv cov neeg ua haujlwm noj qab haus huv.

Txais tos ntawm Rosuvastatin-SZ yog contraindicated nyob rau hauv qhov muaj qhov ua rau mob raum loj (ua kom muaj kabmob Cl hauv qab 30 ml / min).

Rau cov neeg mob uas muaj qhov tsis txaus ua haujlwm ntawm lub raum (Cl creatinine 30-60 ml / min), kev siv rosuvastatin-SZ ntawm ib koob ntawm 40 mg yog contraindicated, thiab ntawm koob tshuaj 5, 10 thiab 20 mg yuav tsum tau siv nrog ceev faj.

Cov neeg mob uas tsis tshua mob lub raum (creatinine Cl siab tshaj 60 ml / min) yuav tsum tau kho nrog koob tshuaj 40 mg nrog ceev faj, saib xyuas raum tsis ua haujlwm. Thaum siv cov tshuaj rau hauv cov neeg mob uas muaj mob tsis haum lub raum kev ua haujlwm, lub koob tshuaj yuav tsum yog 5 mg.

Nrog lub siab ua haujlwm tsis zoo

Hauv lub siab muaj daim siab tsis ua hauj lwm los ntawm 7 cov ntsiab lus thiab hauv qab ntawm qhov ntsuas tus me nyuam-Pugh, nce rau T_1/2 tsis muaj cov rosuvastatin tau kuaj pom, kev nce qib hauv T tau sau tseg rau ob tus neeg mob nrog 8 thiab 9 ntsiab lus_1/2 tsis pub tsawg tshaj 2 zaug. Tsis muaj kev paub dhau los ntawm kev siv Rosuvastatin-SZ hauv cov neeg mob uas nws qhov mob siab dua 9 rau ntawm Child-Pugh nplai.

Kev kho nrog cov tshuaj yog contraindicated nyob rau hauv cov neeg mob uas muaj kab mob siab hauv exacerbation theem, suav nrog nrog kev nce ntxiv ntawm cov ntshav transaminase kev ua si thiab kev nce hauv transaminase kev ua haujlwm, ntau dua 3 zaug siab dua VGN. Nrog kev ceev faj, nws raug nquahu tias Rosuvastatin-SZ siv rau hauv cov neeg mob uas muaj keeb kwm ua rau lub siab puas. Kev txiav txim siab ntawm kev ua haujlwm ntawm daim siab yog qhov tsim nyog ua ntej kev kho mob thiab 3 lub hlis tom qab pib ua haujlwm.

Kev txheeb xyuas txog Rosuvastatin-SZ

Raws li kev txheeb xyuas, Rosuvastatin-C3 yog qhov muaj cov tshuaj lipid-txo qis siv los kho hypercholesterolemia, qeeb qhov muaj mob ntawm atherosclerosis thiab tiv thaiv cov mob plawv. Qhov pib tshwm sim ntawm kev kho yog pom los ntawm ntau tus neeg mob tom qab ib lub lim tiam ntawm kev tswj hwm, thiab cov txiaj ntsig siab tshaj plaws yog 1 hlis tom qab pib ua haujlwm. Raws li kev tshuaj xyuas, vim qhov kev txiav txim ntawm cov tshuaj, theem ntawm cov cholesterol nyob rau hauv cov ntshav txo, ntshav siab nyob ruaj, qhov mob feem ntau txhim kho, ua tsis taus pa thaum taug kev txo qis. Thaum kho, qee qhov, nce lub cev hnyav tuaj yeem txo qis vim qhov sib xyaw ua ke ntawm kev siv tshuaj nrog cov rog hauv lub cev qis.

Qhov tsis zoo ntawm Rosuvastatin-SZ suav nrog coob tus contraindications thiab phiv rov qab. Hauv qee qhov kev tshuaj xyuas, cov neeg mob qhia tsis txaus siab txog tus nqi ntawm cov tshuaj, vim hais tias feem ntau siv sij hawm ntev, tus nqi ntawm cov tshuaj uas yuav tsum tau rau kev kho mob tag nrho, hauv lawv lub tswv yim, yog tus nqi siab.

Tus nqi ntawm Rosuvastatin-SZ hauv cov chaw muag tshuaj

Tus nqi ntawm rosuvastatin-SZ, cov yeeb yaj kiab-coated ntsiav tshuaj nyob ntawm qhov ntau thiab cov ntau thiab tsawg hauv pob, thiab qhov nruab nrab yog:

5 mg tshuaj: 30 pcs. - 180 rubles.,
qhov ntau npaum ntawm 10 mg: 30 pcs. - 350 rub., 90 pcs. - 800 rubles.,
ntau npaum ntawm 20 mg: 30 pieces. - 400 rub., 90 pcs. - 950 RUB.,
ntau npaum ntawm 40 mg: 30 pieces. - 750 rub.