Golda MV > Tshuaj Kho Mob

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog kev hloov pauv hloov: dawb los yog dawb nrog lub daj zas, puag ncig, tiaj-cylindrical, nrog bevel, ntawm cov ntsiav tshuaj nrog qhov ntau npaum ntawm 60 mg muaj kev sib cais sib yuav (rau kev noj tshuaj ntawm 30 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 150, 180, 200 lossis 300 pcs. Hauv cov kaus poom, hauv ib daim ntawv cardboard 1 tuaj yeem, 10 pcs. Hauv cov hlwv pob, hauv ib daim ntawv cardboard 1-10 pob, rau kev siv 60 mg: 10, 20, 25, 30, 40, 50, 60, 70, 75, 80, 84, 90, 100, 120, 125, 140, 150, 180, 250, lossis 300 pcs hauv kaus poom, hauv thawv ntawv thawv 1 tuaj yeem, hauv blister pob: 10 pcs., Ib thawv 1-10 pob, 7 pcs., nyob rau hauv lub thawv 2, 4, 6, 8 lossis 10 pob. Txhua pob kuj muaj cov lus qhia rau kev siv Golda MV).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: gliclazide - 30 lossis 60 mg,
Cov khoom siv pabcuam: lactose monohydrate, sodium carboxymethyl hmoov txhuv nplej siab (hom C), hypromellose 2208, colloidal silicon dioxide, magnesium stearate.

Cov Tshuaj Hauv Tshuaj

Golda MV yog ib qho tshuaj qhov ncauj qhov muag ntshav qab zib tshaj plaws. Gliclazide, nws cov khoom ua haujlwm nquag, yog qhov hloov kho-tso tawm tso tawm ntawm sulfonylurea ntawm lub cim thib ob. Nws yog qhov txawv ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic nplhaib nrog cov kab mob endocyclic. Glyclazide stimulates insulin secretion los ntawm beta hlwb ntawm islets ntawm Langerhans, txo qhov kev xav ntawm cov piam thaj hauv cov ntshav. Tom qab ob xyoos dhau los ntawm txoj kev kho, cov nyhuv ntawm nce ntxiv ntawm cov hnoos qeev postprandial insulin thiab C-peptide mob ntxiv.

Nrog rau cov txiaj ntsig rau cov metabolism hauv cov metabolism, nws muaj cov nyhuv hemovascular. Nyob rau hauv hom 2 mob ntshav qab zib mellitus, gliclazide pab ua kom rov qab qhov kawg ntawm insulin secretion hauv kev teb rau cov piam thaj thiab ua kom cov qib thib ob ntawm insulin secretion. Insulin secretion yog nce ntxiv rau ntawm keeb kwm yav dhau los ntawm kev ua zog vim kev noj zaub mov thiab qab zib tswj.

Cov cuam tshuam hemovascular ntawm gliclazide tshwm sim los ntawm kev txo qis txaus ntshai ntawm cov hlab ntsha me me. Ib nrab inhibits platelet aggregation thiab adhesion, txo qib ntawm kev ua haujlwm ntawm platelet ua haujlwm (thromboxane B2, beta-thromboglobulin). Pab pab txhawm rau ua kom cov nqaij mos plasminogen activator, muaj qhov cuam tshuam rau kev kho rov qab ntawm fibrinolytic kev ua haujlwm ntawm vascular endothelium.

Hauv cov neeg mob uas mob glycemic hemoglobin (Hb_A1c) tsawg dua 6.5%, kev siv ntawm gliclazide muab kev tswj zoo glycemic, txo cov micro- thiab loj heev-cov teeb meem mob ntshav qab zib hom 2 ntshav qab zib.

Lub hom phiaj ntawm gliclazide rau lub hom phiaj ntawm kev tswj hwm glycemic suav kom ntau ntxiv nws cov koob tshuaj hauv kev sib xyaw nrog kev kho mob (lossis hloov nws) ua ntej ntxiv metformin, thiazolidinedione derivative, ib qho alpha-glucosidase inhibitor, insulin lossis lwm yam hypoglycemic tus neeg sawv cev rau nws. Cov txiaj ntsig ntawm kev tshawb fawb soj ntsuam tau pom tias tiv thaiv keeb kwm yav dhau los ntawm kev siv gliclazide nyob hauv nruab nrab txhua hnub ntawm 103 mg (qhov siab tshaj plaws - 120 mg) piv nrog cov qauv tswj kev kho mob, qhov kev pheej hmoo ntawm kev sib koom ua ke ntawm macro- thiab microvascular cov teeb meem yog txo 10%.

Qhov zoo ntawm kev tswj hwm glycemic thaum noj Golda MV suav nrog kev kho mob txo qis hauv kev tshwm sim ntawm cov kab mob xws li muaj teeb meem microvascular (los ntawm 14%), nephropathy (los ntawm 21%), mob raum (los ntawm 11%), microalbuminuria (los ntawm 9%) , macroalbuminuria (30%).

Cov Tshuaj Pharmacokinetics

Tom qab Golda MV tau noj ntawm qhov ncauj, glycazide yog qhov ua kom tiav, nws cov ntshav ntshav nce siab thiab nce mus rau hauv toj siab hauv 6-12 teev. Kev noj zaub mov ib txhij tsis cuam tshuam rau qib ntawm kev nqus, tus neeg tsis txawv txav yog qhov tsis txaus ntseeg. Gliclazide nyob rau hauv ib txog koob tshuaj txog li 120 mg yog tus cwj pwm los ntawm txoj kab sib txuas ntawm qhov lees txais thiab AUC (thaj chaw nyob hauv qhov chaw cia khoom-lub sij hawm pharmacokinetic nkhaus).

Kev khi rau cov ntshav plasma protein - 95%.

Qhov ntim ntawm kev xa tawm yog li 30 litres. Ib koob tshuaj gliclazide ua kom ntseeg tau tias nws qhov kev txiav txim siab zoo hauv cov ntshav ntshav tau tswj xyuas ntau dua 24 teev.

Gliclazide yog metabolized feem ntau hauv lub siab. Tsis muaj cov tshuaj metabolites hauv cov ntshav ntshav.

Kev tshem tawm ib nrab-lub neej yog 12-20 teev.

Nws yog tsuas yog tawm ntawm lub raum ntau dua nyob rau hauv daim ntawv ntawm cov khoom noj khoom haus hloov kho, tsis hloov pauv - tsawg dua 1%.

Hauv cov neeg mob laus, cov kev hloov pauv tseem ceeb hauv cov chaw muag tshuaj tsis yog yam xav tau.

Kev ntsuas rau siv

kev kho mob ntawm hom 2 mob ntshav qab zib mellitus - nyob rau hauv qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo, kev tawm dag zog lub cev thiab poob phaus,
kev tiv thaiv ntawm cov teeb meem hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus - txo cov kev pheej hmoo ntawm microvascular (retinopathy, nephropathy) thiab macrovascular (myocardial infarction, stroke) pathologies los ntawm kev tswj hwm glycemic.

Cov Yuav Tsum Muaj

ntshav qab zib hom 1
kuaj cov ntshav qab zib, mob ntshav qab zib tsis xeev,
mob ketoacidosis,
mob raum tsis ua haujlwm,
mob siab mob siab,
kho kev txawj ntse nrog miconazole,
kev sib txuas ua ke nrog danazol lossis phenylbutazone,
kev tsis haum xeeb lactose, galactosemia, qabzib-galactose malabsorption,
cev xeeb tub lub sijhawm
pub niam mis
hnub nyoog txog 18 xyoo
ib tug neeg tsis qaug rau sulfonylurea derivatives, sulfonamides,
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cov ntsiav tshuaj kub yuav tsum tau siv nrog ceev faj hauv cov neeg laus cov neeg mob lub cev tsis xwm yeem thiab / los yog tsis muaj kev noj haus, cov kab mob hnyav ntawm cov hlab plawv (mob hlab ntshav siab heev, mob ntshav tawm ntawm cov ntshav tsis txaus, mob hnyav carotid arteriosclerosis), ntshav qab zib-6-phosphate dehydrogenase deficiency, raum thiab / lossis daim siab ua haujlwm, lub qog lossis lub ntsws tsis txaus, hypothyroidism, kev kho mob ntev nrog glucocorticosteroids (GCS), kev quav dej quav cawv.

Golda MV, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Cov tshuaj MV kub yog noj ntawm qhov ncauj, nqos tag nrho (tsis tau zom), zoo dua thaum noj tshais.

Qhov koob tshuaj txhua hnub tau noj ib zaug thiab yuav tsum nyob ntawm thaj tsam li 30 txog 120 mg.

Koj tuaj yeem tsis tuaj yeem rov ua qhov yuam kev dhau los ntawm kev noj tshuaj ntxiv hauv koob tshuaj tom ntej, noj ntau dua.

Cov koob tshuaj ntawm gliclazide yog xaiv ib tus zuj zus, suav txog qib theem ntawm cov piam thaj hauv cov ntshav thiab Hb Performance index_A1c.

Cov tshuaj pom zoo: koob thawj zaug yog 30 mg (1 ntsiav tshuaj Kub Kub MV 30 mg lossis ½ ntsiav tshuaj Kub MV 60 mg). Yog tias koob tshuaj qhia tau tswj kev tswj glycemic txaus, tom qab ntawd nws tuaj yeem siv los ua tus saib xyuas txij nkawm. Thaum tsis muaj qhov kev kho mob txaus txaus tom qab 30 hnub ntawm kev kho, qhov kev pib siv tshuaj maj mam nce ntxiv ntawm 30 mg (nce txog 60, 90, 120 mg). Qee qhov tshwj xeeb, yog tias tus neeg mob cov ntshav qabzib hauv lub cev tsis tau poob qis tom qab 14 hnub ntawm kev kho, koj tuaj yeem txuas ntxiv nce qhov kev noj tshuaj 14 hnub tom qab pib ua haujlwm.

Qhov siab tshaj plaws niaj hnub noj yog 120 mg.

Yog tias koj hloov los ntawm kev noj tam sim ntawd tso glyclazide ntsiav tshuaj ntawm koob ntawm 80 mg, koj yuav tsum pib noj cov tshuaj hloov kho nrog lub koob tshuaj 30 mg, nrog rau kev kho mob nrog ceev ceev glycemic tswj.

Thaum hloov mus rau Golda MV nrog rau lwm cov tshuaj hypoglycemic, lub sijhawm hloov pauv ib txwm tsis tas yuav tsum ua. Thawj koob tshuaj gliclazide nyob rau hauv hloov kho cov ntsiav tshuaj yuav tsum yog 30 mg, ua raws li kev pom zoo nyob ntawm seb cov concentration ntawm cov piam thaj hauv cov ntshav.

Thaum txhais lus, cov koob tshuaj thiab ib nrab-lub neej ntawm cov tshuaj tiv thaiv hypoglycemic dhau los yuav tsum raug coj los txiav txim. Yog hais tias sulfonylurea derivatives nrog ntev ib nrab-lub neej tau hloov, tom qab ntawd txhua tus kab mob hypoglycemic tuaj yeem nres rau ob peb hnub. Qhov no yuav zam tsis txhob mob ntshav qabzib vim yog lub txiaj ntsig ntxiv ntawm glycoslazide thiab sulfonylurea derivatives.

Kev siv cov Golda MV hauv kev sib xyaw ua ke nrog alpha-glucosidase inhibitors, biguanides lossis insulin yog qhia.

Cov neeg laus muaj hnub nyoog (laus dua 65 xyoos) tsis tas yuav hloov kho qhov koob.

Hauv qhov mob me mus rau lub raum tsis ua haujlwm, tsis tas yuav hloov kho qhov tshuaj.

Nws raug nquahu kom siv qhov tsawg kawg nkaus (30 mg) ntawm lub sijhawm ntev-ua yeeb yam gliclazide rau kev kho mob ntawm cov neeg mob uas muaj kev pheej hmoo ntawm kev mob hypoglycemia, kev noj zaub mov tsis xwm yeem lossis tsis txaus, kev cuam tshuam ntawm cov tshuaj endocrine tsis txaus, hypothyroidism, cov kab mob hnyav ntawm cov hlab plawv, lub sijhawm tom qab siv sijhawm ntev thiab / lossis kev tswj hwm ntawm kev txhaj tshuaj siab glucocorticosteroids (GCS).

Kev siv cov Golda MV ntxiv rau kev noj haus thiab kev tawm dag zog kom tiv thaiv cov teeb meem ntawm cov ntshav qab zib hom 2 yuav tsum tau pib nrog kev noj tshuaj ntawm 30 mg. Yuav kom ua tiav cov kev siv glycemic tswj thiab cov hom phiaj Hb_A1c thawj koob tshuaj tuaj yeem raug maj mam nce mus txog qhov ntau kawg ntawm 120 mg ib hnub twg. Lub hom phiaj ntawm cov tshuaj rau lub hom phiaj ntawm kev siv tshuaj tiv thaiv glycemic yog qhia ua ke nrog metformin, ib qho alpha-glucosidase inhibitor, thiazolidinedione derivative, insulin thiab lwm yam kab mob hypoglycemic.

Sab sij huam

Nrog rau kev tshem tawm ntawm pluas noj tom ntej lossis kev noj zaub mov tsis xwm yeem, cov tsos mob ntawm kev mob ntshav qab zib tsawg tuaj yeem tshwm sim: qaug zog ntau dua, kev tshaib plab, mob taub hau, ncua tshuaj tiv thaiv, xeev siab, ntuav, poob qis, kiv taub hau, qaug zog, pw tsaug zog, txob taus, ntxhov siab, kev nyuaj siab, tsis pom kev thiab tsis hais lus, paresis, aphasia, tshee tshee, poob ntawm kev tswj yus tus kheej, lub siab xav, hnov qhov tsis paub pab, ua tsis taus pa, ua pa nyuaj, bradycardia, delirium, nkees st, tsis nco qab, coma (xws li neeg tuag taus), adrenergic teb - ntau zog tawm hws, ntxhov siab vim, clammy daim tawv nqaij ntawm lub cev, tachycardia, nce ntshav siab (ntshav siab), arrhythmia, palpitations, angina pectoris. Cov txiaj ntsig ntawm kev tshawb fawb soj ntsuam qhia tau tias thaum siv cov tshuaj rau lub hom phiaj ntawm kev tswj hwm glycemic, hypoglycemia tshwm sim ntau dua nrog cov tshuaj glycemic tswj. Feem ntau ntawm cov ntshav qog ntshav qis nyob rau hauv kev siv ntshav glycemic tswj pab pawg tau tshwm sim tawm tsam ntawm keeb kwm ntawm kev tsim cov tshuaj insulin.

Tsis tas li ntawd, tawm tsam keeb kwm ntawm kev siv Golda MV, cov kev mob tshwm sim txuas ntxiv tuaj:

los ntawm lub plab zom mov: mob plab, xeev siab, ntuav, raws plab, cem quav,
los ntawm cov lymphatic thiab circulatory systems: tsis tshua muaj - thrombocytopenia, anemia, leukopenia, granulocytopenia,
los ntawm cov kab mob hepatobiliary: nce kev ua si ntawm alkaline phosphatase, ACT (aspartate aminotransferase), ALT (alanine aminotransferase), kab mob siab, mob cholestatic daj ntseg,
nyob rau ib feem ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: cov tsis pom kev txawv txav (ntau zaus thaum pib kho),
dermatological tshua: ua pob khaus, tawm pob, ua pob ua pob maculopapular, urticaria, erythema, Quincke's edema, cov kev mob tshwm sim (nrog rau Stevens-Johnson syndrome, lom ua paug epidermal necrolysis),
lwm yam (kev mob tshwm sim los ntawm sulfonylurea derivatives): hemolytic anemia, erythrocytopenia, agranulocytosis, kev tsis haum vasculitis, pancytopenia, hyponatremia, daj ntseg, lub siab tsis ua haujlwm.

Noj ntau dhau

Cov tsos mob: nrog ib tug overdose, cov tsos mob ntawm tus yam ntxwv hypoglycemia tsim.

Kev Kho Mob: kom tsis txhob mob ntshav qab zib tsawg (tsis muaj tus mob neurological thiab lub siab tsis nco qab zoo), nws yog qhov tsim nyog los txhawm rau nce carbohydrate kom tsawg, txo koob tshuaj ntawm Golda MV thiab / lossis hloov pauv kev noj zaub mov. Ua tib zoo saib kev kho mob ntawm tus neeg mob lub sijhawm.

Nrog cov tsos mob ntawm cov mob hypoglycemic loj (tsis nco qab, ntuag thiab lwm yam cuam tshuam ntawm cov mob neurological), yuav tsum tau mus pw hauv tsev kho mob tam sim.

Kev kho mob kub ntxhov ceev rau hypoglycemic coma lossis kev xoom xaim ntawm nws cuam tshuam txog cov tshuaj tiv thaiv (iv) txhaj tshuaj 20-30% dextrose (qabzib) hauv ib koob tshuaj 50 ml, tom qab ntawv iv dej tshuaj ntawm 10% dextrose tov, uas tswj cov theem ntawm cov piam thaj hauv ntshav saum toj 1 g / l. Kev saib zoo ntawm tus neeg mob tus mob thiab saib xyuas ntshav qabzib siab yuav tsum tau txuas ntxiv mus rau 48 teev.

Kev lim ntshav yog qhov ua tsis zoo.

Cov lus qhia tshwj xeeb

Golda MV yuav tsum tau sau tseg tsuas yog tias tus neeg mob noj zaub mov nrog rau noj tshais, thiab zaub mov noj kom tsawg. Qhov no cuam tshuam nrog kev pheej hmoo siab ntawm kev nthuav dav hypoglycemia, suav nrog cov ntawv loj thiab lub sijhawm ntev uas yuav tsum tau mus pw hauv tsev kho mob thiab iv kev tswj hwm ntawm kev daws teebmeem rau ob peb hnub. Thaum lub sij hawm kev nqus ntawm Golda MV, nws yog qhov tseem ceeb heev kom ntseeg tau tias muaj kev paub txaus ntawm carbohydrates hauv lub cev nrog zaub mov noj. Kev noj zaub mov tsis xwm yeem, kev noj zaub mov tsis txaus, lossis zaub mov tsis rog los yog cov khoom noj ua si carbohydrate yuav ua rau lub cev tsis muaj ntshav qab zib. Ntau zaus, txoj kev txhim kho hypoglycemia tau pom nyob hauv cov neeg mob uas ua raws cov zaub mov tsis zoo, tom qab kev ua kom lub cev ntaug lossis ntev lub cev, haus dej cawv lossis thaum kho nrog ntau tus neeg mob qog ntshav qab zib tib lub sijhawm. Feem ntau, cov zaub mov muaj protein-carbohydrate (suav nrog qab zib) tuaj yeem pab txo cov tsos mob ntawm kev mob ntshav qab zib. Hauv qhov no, cov piam thaj hloov tsis zoo. Nws yuav tsum tau yug los hauv lub siab tias kev tuaj yeem txo rov qab mob tau tshwm sim. Yog li, yog tias qhov ntshav qab zib tsawg (hypoglycemia) muaj qhov qhia tau cov tsos mob lossis qhov xwm txheej ntev ntev, txawm hais tias qhov zoo ntawm kev noj cov khoom noj uas yog carbohydrate, koj yuav tsum nrhiav kev kho mob sai.

Thaum xaiv Golda MV, kws kho mob yuav tsum qhia tus neeg mob kom ntxaws txog kev kho thiab qhov yuav tsum tau ua raws li cov tshuaj noj kom nruj, kev noj zaub mov zoo rau lub cev thiab kev tawm dag zog.

Qhov laj thawj ntawm kev txhim kho cov ntshav qab zib yog tus neeg mob lub cev tsis tuaj yeem lossis tsis txaus siab (tshwj xeeb tshaj yog thaum muaj hnub nyoog laus) ua raws li tus kws kho mob cov lus qhia thiab tswj cov ntshav qab zib, noj zaub mov tsis txaus, kev hloov pauv ntawm kev noj zaub mov, tsis noj mov los yog tshaib plab, tsis txaus ntawm kev siv lub cev thiab cov khoom noj uas tau txais carbohydrates, mob siab rau lub siab , raum tsis ua haujlwm, kev siv tshuaj ntau dhau, txhaj tshuaj tsis txaus thiab adrenal tsis txaus thiab / lossis tus kabmob thyroid.

Tsis tas li ntawd, hypoglycemia tuaj yeem ua kom muaj kev sib cuam tshuam ntawm gliclazide nrog cov tshuaj concomitant kho. Yog li, tus neeg mob yuav tsum pom zoo nrog ib tus kws kho mob ntawm kev noj ib qho tshuaj twg.

Thaum xaiv Golda MV, tus kws kho mob yuav tsum qhia rau tus neeg mob thiab nws tsev neeg kom paub meej txog cov kev pheej hmoo thiab txiaj ntsig ntawm kev kho mob tom ntej, qhov ua rau thiab cov tsos mob ntawm tus mob ntshav qab zib, qhov tseem ceeb ntawm kev ua raws li kev noj zaub mov pom zoo thiab cov kev tawm dag zog lub cev, kev pom zoo ntawm kev tswj xyuas tus kheej ntawm cov ntshav qabzib.

Txhawm rau ntsuas ntsuas glycemic tswj, Hb yuav tsum tau ntsuas tas li._Alc.

Nws yuav tsum tau yug los hauv lub siab tias nrog concomitant hepatic thiab / lossis lub raum tsis ua haujlwm, lub xeev ntawm kev mob ntshav qab zib tuaj yeem mus ntev thiab xav tau cov kev kho mob uas tsim nyog tam sim.

Kev tswj glycemic tiav tuaj yeem ua kom tsis muaj zog los ntawm kev tshwm sim ua npaws, kis kab mob, raug mob los yog kev phais mob ntxiv. Hauv cov mob no, nws raug nquahu kom hloov tus neeg mob mus rau kev kho mob insulin.

Qhov tsis muaj txiaj ntsig ntawm gliclazide tom qab lub sijhawm ntev ntev ntawm kev kho mob yuav yog vim muaj cov tshuaj tiv thaiv kab mob theem nrab, uas yog qhov tshwm sim ntawm kev nce qib ntawm tus kabmob lossis txo qis hauv cov lus teb soj ntsuam rau cov tshuaj. Thaum kuaj pom cov tshuaj tiv thaiv kab mob theem ob, nws yog qhov tsim nyog yuav tsum ua kom ntseeg tau tias tus neeg mob ua raws li cov khoom noj tau hais tseg thiab tshuaj xyuas qhov tsis txaus ntawm koob tshuaj Golda MV.

Nrog lub cev tsis muaj cov piam thaj-6-phosphate dehydrogenase, kev siv sulfonylurea derivatives ua rau muaj kev pheej hmoo ntawm hemolytic anemia. Yog li, rau kev kho mob ntawm cov neeg mob uas muaj cov piam thaj-6-phosphate dehydrogenase tsis txaus, cov kab mob hypoglycemic ntawm lwm pab pawg yuav tsum tau xav.

Yeeb tshuaj sib cuam tshuam

miconazole: kev tswj hwm system ntawm miconazole los yog nws siv nyob rau hauv daim ntawv ntawm gel ntawm lub qhov ncauj ua rau lub cev ua rau muaj qhov nce ntawm hypoglycemic ntawm gliclazide, uas tuaj yeem ua rau kev txhim kho hypoglycemia mus txog thaum tsis nco qab,
phenylbutazone: ua ke nrog cov tshuaj ntawm qhov ncauj ntawm phenylbutazone ua rau lub ntsej muag hypoglycemic zoo ntawm Golda MV, yog li ntawd, yog tias nws tsis tuaj yeem sau tshuaj rau lwm cov tshuaj tiv thaiv, nws yog qhov tsim nyog los kho qhov koob tshuaj glyclazide ob qho tib si thaum tswj hwm phenylbutazone thiab tom qab nws tshem tawm,
ethanol: kev siv cawv haus cawv los yog cov tshuaj cawv uas muaj cov tshuaj pleev cov tshuaj tiv thaiv kev tiv thaiv rov qab, uas tuaj yeem ua rau cov ntshav qabzib ntau dua lossis kev txhim kho hypoglycemic coma,
lwm cov kab mob hypoglycemic (insulin, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, glucagon-zoo li peptide-1 receptor agonists), beta-blockers, fluconazole, angiotensin hloov enzyme inhibitors (thaiv kab mob, enaprilap)₂-histamine receptors, monoamine oxidase inhibitors, sulfonamides, clarithromycin, cov tshuaj tiv thaiv tsis haum tshuaj: kev sib xyaw ntawm cov tshuaj no nrog glycazide yog nrog los ntawm kev nce hauv kev nqis tes ntawm Golda MV thiab kev pheej hmoo ntawm hypoglycemia,
danazol: lub txiaj ntsig diabetogenic ntawm danazol pab ua kom cov nyhuv ntawm gliclazide tsis muaj zog,
chlorpromazine: siab kawg txhua hnub koob tshuaj (ntau tshaj 100 mg) ntawm chlorpromazine txo cov insulin secretion, pab txhawb kev nce ntshav hauv cov ntshav siab. Yog li no, nrog concomitant antipsychotic therapy, xaiv cov koob tshuaj ntawm gliclazide thiab ceev faj glycemic tswj, suav nrog tom qab tsis ua tiav ntawm chlorpromazine, yuav tsum muaj,
tetracosactide, GCS rau kev siv kab ke thiab tshuaj pleev: txo qis kev ua kom yuag, ua rau muaj glycemia ntau ntxiv thiab kev pheej hmoo ntawm kev txhim kho ketoacidosis. Ua tib zoo saib xyuas cov ntshav qabzib hauv qib yuav tsum tau, tshwj xeeb tshaj yog thaum pib ntawm kev sib koom tes, yog tias tsim nyog, kev hloov kho tshuaj ntawm gliclazide,
ritodrin, salbutamol, terbutaline (iv): nws yuav tsum nco ntsoov tias beta₂-adrenomimetics nce qib ntawm cov piam thaj hauv cov ntshav, yog li ntawd, thaum ua ke nrog lawv, cov neeg mob xav tau glycemic tswj hwm tus kheej, nws muaj peev xwm hloov tus neeg mob mus rau kev kho mob insulin,
warfarin thiab lwm yam tshuaj anticoagulants: gliclazide tuaj yeem ua rau muaj kev cuam tshuam loj hauv kev saib xyuas ntawm cov nyhuv ntawm anticoagulants.

Cov lus piv txwv ntawm Golda MV yog: Diabetalong, Glidiab, Gliclada, Gliclazide Canon, Gliclazide MV, Gliclazide-SZ, Gliclazide-Akos, Diabeton MB, Diabinax, Diabefarm, Diabefarm MV, thiab lwm yam.

Xyuas txog kub MV

Kev txheeb xyuas txog Kub MV yog qhov muaj teeb meem. Cov neeg mob (lossis lawv cov neeg txheeb ze) qhia txog kev ua tiav sai sai ntawm kev txiav txim siab qab zib kom txaus thaum noj tshuaj, thaum muaj kev pheej hmoo ntawm cov ntshav qab zib thiab lwm cov kev mob tshwm sim. Tsis tas li ntawd, muaj cov contraindications yog suav tias yog qhov tsis txaus ntseeg.

Thaum lub sijhawm ua haujlwm ntawm Golda MV, nws raug nquahu kom soj ntsuam xyuas kev noj zaub mov kom zoo thiab kev noj zaub mov kom zoo, tswj xyuas ntshav qab zib txhua hnub.