Lozap 100 ntxiv rau

Lozap muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj convex ntawm ob sab hauv txheej dawb zaj duab xis txheej. Cov khoom lag luam yog npaj rau kev tswj hwm qhov ncauj. Ntim hauv cov hlwv rau 10 ntsiav tshuaj thiab ntim hauv pob ntawm 30, 60, 90 daim. Cov qov ntawm cov ntsiav tshuaj suav nrog:

• poov tshuaj losartan (cov tshuaj ua kom nquag plias),
• microcrystalline cellulose,
• povidone
• magnesium stearate,
• croscarmellose sodium,
• hypromellose,
• macrogol
• mannitol
• dimethicone
• talcum hmoov
• daj zas.

Kev lag luam kws tshuaj niaj hnub muaj ob daim ntawv tshuaj ntawm cov tshuaj no: Lozap thiab Lozap ntxiv. Thawj qhov kev xaiv tsuas muaj cov tshuaj nquag - losartan. Nws yog ib qho angiotensin hloov ua enzyme (ACE) inhibitor. Qhov thib ob ntxiv tivthaiv uas txhim kho cov nyhuv ntawm losartan potassium yog hydrochlorothiazide. Nws tshem tawm cov kua dej ntau dhau, uas tseem yuav pab txo lub siab. Rau kev kho mob tawg, tshwj xeeb tshaj yog cov ntawv loj, nws yog qhov zoo dua los siv cov tshuaj sib xyaw, vim lawv muaj cov nyhuv hypotensive muaj zog.

Hauv tsev muag tshuaj koj tuaj yeem tuaj yeem yuav cov ntsiav tshuaj siab Lozap hauv ntau cov tshuaj noj: 12.5 mg, 50 thiab 100. Lozap ntxiv rau tsuas yog ib qho - 50 mg ntawm potassium losartan thiab 12.5 mg ntawm hydrochlorothiazide.

Pharmacological kev txiav txim

Lozap muaj txiaj ntsig zoo txo ​​cov ntshav siab, txo cov load ntawm lub plawv mob. Cov cuab yeej no ntawm cov tshuaj yog muab los ntawm nws lub peev xwm los txwv ACE kev ua haujlwm, uas pab hloov pauv angiotensin-I mus rau angiotensin-II.

Raws li qhov tshwm sim, ib yam tshuaj uas cuam tshuam rau kev ua haujlwm ntawm vasoconstriction, thiab vim li ntawd, kev nce ntshav nce siab, angiotensin-II, nres kiag li hauv lub cev. Tsuas yog thaum lub zog ntawm cov tshuaj hormones no txhawm rau tuaj yeem ua rau txo ntshav siab tseem ceeb thiab lawv qhov kev ua kom zoo li qub tau.

Qhov kev ua ntawm cov tshuaj pib ib teev tom qab txhaj koob tshuaj ntawm thawj lub ntsiav tshuaj thiab kav mus txog ib hnub. Qhov siab tshaj plaws tau tiav tawm tsam ntawm keeb kwm ntawm kev tswj hwm tsis tu ncua ntawm cov tshuaj. Qhov nruab nrab chav kawm ntawm kev kho mob yog 4-5 lub lis piam. Nws yog qhov ua tau los siv Lozap hauv ob tus neeg laus thiab cov hluas, tshwj xeeb tshaj yog nrog kev txhim kho ntawm malignant arterial tawg.

Vim tias nthuav cov hlab ntsha tuaj, nws yuav yooj yim dua rau cov leeg plawv kom thawb ntshav hauv lawv. Raws li qhov tshwm sim, lub cev tsis kam tiv thaiv kev mob lub cev thiab lub siab lub ntsws tau nce siab, uas yog tswj cov kev mob ntawm cov neeg mob kev mob plawv. Tsis tas li ntawd, cov tshuaj rau lub siab Lozap nce rau cov ntshav kev pab rau lub plawv, txhim kho ntshav txaus hauv lub raum, yog li nws tuaj yeem siv rau nephropathy ntawm ntshav qab zib etiology thiab lub plawv tsis ua haujlwm.

Lozap txig ua ke nrog lwm cov tshuaj kom txo qhov siab. Vim tias nws muaj txiaj ntsig diuretic, nws pab tshem tawm cov kua qog tawm hauv lub cev. Lozap ntxiv rau cov ntsiav tshuaj muaj cov nyhuv ntau dua, txij li thaum hydrochlorothiazide tam sim no hauv qhov muaj pes tsawg leeg ua kom cov nyhuv hypotensive ntawm losartan.

Ib qho ntxiv thiab tseem ceeb ntawm cov tshuaj yog nws lub peev xwm los tshem tawm uric acid tawm ntawm lub cev thiab txo nws cov tshuaj lom hauv cov ntshav. Thaum xaus ntawm kev txais tos, "kev tshem tawm" cov kabmob tsis muaj.

Pharmacodynamics thiab pharmacokinetics

Losartan yog qhov kev paub tseeb angiotensin II receptor antagonist. Nws txo cov kev tawm tsam tag nrho hauv cov hlab ntsha, pab txo aldosterone thiab adrenaline hauv cov ntshav. Muaj qhov ib txwm ua haujlwm ntawm kev ua kom siab ntawm kev mob ntsws, nrog rau cov ntsuas ntshav siab. Nrog rau kev siv tas li, Lozap tiv thaiv cov tuab ntawm myocardium, nce lub siab ntawm lub siab mus rau kev tawm dag zog lub cev.

Tom qab ib daim ntawv thov nkaus xwb, cov nyhuv ntawm cov tshuaj nce mus txog qhov siab kawg tom qab 6 teev, thiab tom qab ntawd maj mam txo qis thiab nres tom qab 24 teev. Qhov siab tshaj plaws ntawm kev tiv thaiv hypotensive tshwm sim tom qab kwv yees li 3-5 lub lis piam ntawm cov thawj coj hauv chav kawm.

Losartan nrawm nrawm rau lub plab hnyuv plab zom mov. Nws cov peev txheej xyoob ntoo yog kwv yees li 33%; nws khi rau cov ntshav protein li 99%. Nws cov txiaj ntsig ntawm ntshav ntau tau ua tiav tom qab 3-4 teev. Qhov nqus ntawm cov tshuaj tsis pauv hloov ua ntej lossis tom qab noj mov.

Thaum noj losartan poov tshuaj, kwv yees li 5% yog tawm los ntawm lub raum hauv daim ntawv hloov pauv thiab me ntsis ntau dua 5% hauv daim ntawv ntawm lub cev nquag. Hauv kev mob hnyav ntawm kev haus cawv, lub siab ntawm cov tshuaj nquag muaj 5 zaug siab dua hauv cov neeg muaj kev noj qab haus huv, thiab cov nquag metabolite yog 17 zaug.

Cov lus qhia rau leej twg los taw

Cov tshuaj yog siv los ua cov tshuaj ywj siab, thiab ua ib feem ntawm txoj kev kho mob. Nws yog ntawv kho rau kev kho mob ntawm cov mob hauv qab no thiab cov kab mob:

• ntshav siab
• lub plawv tsis ua hauj lwm (raws li cov cuab yeej ntxiv),
• cov kab mob ntshav qab zib rau cov neeg mob ntshav qab zib mellitus,
• los txo cov kev pheej hmoo ntawm kev tsim mob plawv.

Cov Yuav Tsum Tau Ua

Kev siv ntawm Lozap yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hyperkalemia, cev xeeb tub, thiab lactation. Cov tshuaj tsis tau sau tseg rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, vim nws txoj kev nyab xeeb thiab ua haujlwm tsis tau tsim. Contraindication tseem hypersensitivity rau lub Cheebtsam ntawm cov tshuaj lossis lawv intolerance. Lozap yog siv nrog kev ceev faj hauv lub raum lossis lub siab ua haujlwm, kev mob ntshav hauv lub hlwb, lossis lub cev qhuav dej.

Cov lus qhia rau kev siv

Ib qho ntawm qhov zoo ntawm Lozap yog ntau zaus siv - 1 zaug nyob rau ib hnub. Nws yog kws kho txawm yuav noj mov dabtsi los xij. Cov qauv tshuaj rau txhua hnub rau kev kub siab yog 50 mg. Yog tias tsim nyog, nws tuaj yeem nce ntxiv txog 100 mg hauv ib lossis ob koob tshuaj. Yog tias cov tshuaj tau sau rau cov neeg mob uas siv cov tshuaj diuretic siab, tom qab ntawd thawj zaug ntawm Lozap yuav tsum tsis pub tshaj 25 mg rau ib hnub.

Cov lus qhia rau kev siv Lozap qhia tau hais tias nrog lub plawv tsis ua hauj lwm, cov tshuaj no tau los ntawm 12,5 mg, tom qab ntawd qhov koob tshuaj tau nce qeeb zuj zus (tsom kwm ntawm lub lis piam sib nrug) mus rau qhov nruab nrab txij nkawm tshuaj ntawm 50 mg. Hauv cov neeg mob uas muaj lub siab tsis ua haujlwm, lub raum lossis lim ntshav, cov koob tshuaj thawj zaug yuav tsum raug txo kom tsawg.

TSEEM CEEB YUAV TSUM! Tsis muaj kev ua pa luv, mob taub hau, tawm ntawm lub siab thiab lwm cov tsos mob ntawm HYPERTENSION! Tshawb nrhiav tus txheej txheem uas peb cov neeg nyeem siv los kho lub siab. Kawm tus qauv.

Vim li cas lwm tus muab tshuaj Lozap? Lawv tau zoo yog tias nws yog qhov yuav tsum tau ua kom txo qis kev pheej hmoo ntawm kev tsim mob plawv thiab tuag rau cov neeg mob ntshav siab. Txhawm rau kho cov xwm txheej zoo li no, kev noj tshuaj 50 mg ib hnub rau ib hnub yog kws kho mob. Yog tias qib theem ntawm cov ntshav siab tsis tiav, ces yuav tsum hloov qhov koob tshuaj thiab ntxiv cov kev kho mob hydrochlorothiazide.

Tus kws kho mob yuav tsum xaiv qhov ntau ntawm cov tshuaj, txij li tsuas yog nws paub ntawm qhov siab thiab qhov ntau npaum li cas Lozap siv tau zoo tshaj. Kev ywj pheej pauv hauv kev haus tshuaj tuaj yeem ua rau muaj kev tsis zoo.

Sab sij huam

Feem ntau, losartan poov tshuaj zoo zam tau. Cov kev mob tshwm sim tsis tshua muaj tshwm sim, dhau mus sai heev, tsis tas yuav tsum tsis txuas lub tshuaj ntxiv. Cov xwm txheej tsis zoo uas tau tshwm sim hauv tsawg dua 1% ntawm cov neeg mob tsis cuam tshuam nrog kev noj Lozap.

Los ntawm ib sab ntawm lub hauv nruab nrab cov hlab hlwb, kev txhim kho kiv taub hau, mob hawb pob, ua kom lub cev qaug zog, tsis quav ntsej, thiab pw tsaug zog zoo. Qee lub sij hawm muaj ntau yam parasthesia, tshee tshee, tinnitus, depressive mob. Muaj qee zaus, pom kev tsis pom kev, pom pob txha taub hau, mob taub hau mob taub hau tau sau tseg.

Lub tshuab ua pa tuaj yeem teb rau cov tshuaj los ntawm kev tshwm sim ntawm qhov ntswg, hnoos qhuav, kev txhim kho ntawm rhinitis, mob ntsws txhaws txog siav.

Los ntawm kev mob plab hnyuv: xeev siab, ntuav, raws plab, tsam plab, tsam muaj teeb meem, muaj kua qaub ntau ntawm lub plab ua kua, cem quav. Tsis tas li, thaum noj cov tshuaj, qhov tshwm sim ntawm kev ua txhaum ntawm cov hlab plawv: tachycardia, arrhythmia, bradycardia, angina pectoris.

Cov kev mob tshwm sim los ntawm thaj tsam ntawm daim tawv nqaij, genitourinary system thiab musculoskeletal system tshwm sim hauv tsawg dua 1% ntawm cov neeg mob.

Noj ntau dhau

Nrog kev siv ntau dhau ntawm cov tshuaj Lozap, txo qis hauv cov ntshav siab, kev txhim kho ntawm tachycardia yog ua tau. Nyob rau hauv kev siv los ntawm kev sib tsoo ntawm kev siv tshuaj ntau dua, kev txhawb nqa cov tsos mob tshwm sim yog nqa tawm. Nco ntsoov txhawb kev ntuav, pais plab lav, yuam kev diuresis.

Tseem Ceeb: Hemodialysis tsis muaj peev xwm tshem cov vitamins losartan thiab nws cov metabolite los ntawm lub cev.

Kev cuam tshuam nrog lwm yam tshuaj

Tej zaum siv Lozap siv nrog lwm cov tshuaj tiv thaiv kabmob ntshav. Nyob rau tib lub sijhawm, lawv cov kev ua zuj zus ntxiv. Kev sib cuam tshuam tseem ceeb ntawm losartan nrog digoxidine, phenobarbital, anticoagulants, cimetidine thiab hydrochlorothiazide tsis tau pom. Flucanazole thiab rifampicin tuaj yeem txo qib ntawm cov metabolite nquag, txawm li cas los xij, kev kho mob hauv chav kho mob los ntawm qhov kev sib txuam no tsis tau kawm.

Nrog rau kev teem sijhawm ntawm Lozap hauv kev sib xyaw nrog cov tshuaj potassium-sparing diuretics, kev txhim kho ntawm hyperkalemia muaj peev xwm ua tau. Cov nyhuv zoo dua ntawm losartan, zoo li lwm cov tshuaj tiv thaiv kabmob, tuaj yeem txo nrog indomethacin.

Siv rau lub sijhawm menyuam yaus thiab hnub nyoog laus

Lozap tsis siv rau hauv cov menyuam yaus hnub nyoog qis dua 18 xyoo, vim nws tsis tau ntsuas rau nws qhov kev ua haujlwm thiab kev nyab xeeb. Thawj qhov muab tshuaj rau cov neeg mob laus yuav tsum tsis siab tshaj 50 mg. Hauv qhov no, kev kho mob yuav tsum tau ua nyob rau hauv kev saib xyuas tas li ntawm tus kws kho mob thiab nrog kev soj ntsuam tas li. Yog tias cov tshuaj tsis ua hauj lwm zoo, yuav tsum tau hloov kho qhov noj tshuaj lossis hloov nws cov tshuaj noj.

Lozap thiab cev xeeb tub

Kev siv cov tshuaj tsis pom zoo hauv thawj lub hlis thaum cev xeeb tub, thiab yog contraindicated ntawm ib hnub tom qab. Cov ntaub ntawv tau txais thaum lub sijhawm kawm txog kev cuam tshuam ntawm ACE inhibitors ntawm tus menyuam hauv thawj peb lub hlis ntawm nws txoj kev txhim kho tsis ntseeg, tab sis qhov kev pheej hmoo tsis yog cais tag nrho.

Nws muaj kev ntseeg tau paub tias kev siv losartan poov tshuaj hauv qhov thib ob, zaum thib peb ntawm cev xeeb tub muaj qhov tsis zoo rau kev txhim kho tus me nyuam hauv plab. Muaj qhov ua kom lub raum ua haujlwm, qhov ua kom qeeb ntawm kev txhim kho cov pob txha pob txha taub hau. Yog li no, thaum lees paub tias cev xeeb tub, kev nqus ntawm losartan poov tshuaj yog nres sai, thiab tus neeg mob tau kho dua lwm txoj, kev maj mam kho ntau dua.

Tsis muaj xov xwm hais txog kev faib Lozap rau niam mis. Yog li, cov pojniam lactating yuav tsum tau caiv txhob noj yam tshuaj no. Yog tias maj nrawm siv cov tshuaj no thaum lub sijhawm pub mis, yuav tsum tsis txhob pub mis rau menyuam noj.

Cov lus qhia tshwj xeeb

Ntxiv nrog rau kev sib xyaw Lozap nrog lwm cov tshuaj tiv thaiv kabmob, nws txoj kev tswj hwm tuaj yeem ua ke nrog cov tshuaj insulin thiab hypoglycemic (Gliclazide, Metformin thiab lwm tus). Yog tias tus neeg mob muaj keeb kwm ntawm Quincke's edema, kev saib xyuas kev kho mob tas li yog qhov tsim nyog thaum lub sijhawm ntawm losartan thawj coj. Qhov no yog qhov tsim nyog los tshem tawm qhov kev pheej hmoo ntawm kev rov qab tshwm sim ntawm kev fab tshuaj.

Yog hais tias lub cev muaj cov kua dej tsawg, uas yuav yog los ntawm kev noj ntsev tsis muaj mob, raws plab, ntuav indomitable, los sis tsis nco qab noj haus, ces noj cov tshuaj tuaj yeem ua rau muaj ntshav siab ntau dua (hypotension). Ua ntej thov Lozap, nws raug nquahu kom rov qab kho cov dej-electrolyte sib npaug hauv lub cev lossis siv cov tshuaj hauv cov tshuaj kom tsawg kawg nkaus.

Thaum muab tshuaj rau cov neeg mob uas lub raum tsis ua haujlwm, lub plawv tsis ua haujlwm lossis ntshav qab zib mellitus, nws yog qhov yuav tsum tau soj ntsuam theem ntawm creatinine thiab poov tshuaj thaum lub sijhawm tag nrho kev kho mob, txij li kev pheej hmoo ntawm kev tsim hyperkalemia muaj siab heev. Txij li thaum mob raum los yog mob qog txha ntshav txhaws tuaj yeem tuaj yeem ua rau lub hauv plab tsis zoo, losartan yuav tsum tau siv nrog kev ceev faj heev.

Tsis txhob noj Lozap nrog lwm ACE inhibitors, piv txwv li, Enalopril thiab Captopril. Tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj loog dav dav, kev txhim kho ntawm hypotension yog tau.

Muaj feem xyuam rau kev muaj peev xwm ntawm kev tsav tsheb

Txij li thaum qhov kev nqus ntawm losartan poov tshuaj tuaj yeem ua rau kiv taub hau thiab tsaus muag, yog li nws pom zoo kom tso tseg txhua yam haujlwm uas yuav tsum muaj kev xav txog kev noj qab haus huv tom qab noj tshuaj. Nrog rau kev tsav tsheb.

Cov tuam txhab lag luam niaj hnub muaj ntau cov yeeb yaj kiab ntawm Lozap los ntawm ntau cov tuam ntxhab. Ntawm lawv, koj tuaj yeem nrhiav cov tshuaj muaj nqi dua lossis pheej yig dua. Cov tshuaj hauv cov lus nug thiab nws cov analogues tuaj yeem muaj cov txiaj ntsig sib txawv, yog li ntawd, thaum xaiv nws, koj yuav tsum xub tham nrog koj tus kws kho mob.

Ntawm cov analogues niaj hnub ntawm Lozap, cov feem ntau muaj:

Tag nrho cov tshuaj no muaj tib qhov ntsuas thiab sib kis rau kev siv, sib txawv hauv tsuas tshuaj, nqi thiab chaw tsim khoom.

Tseem Ceeb: Cov tshuaj tsis yog tsim rau cov mob hnyav ntawm kev mob ntshav ntawm txoj hlab ntshav tawg. Hauv cov xwm txheej zoo li no, kev teem sij hawm ntawm txoj kev kho kom ncaj ncees yog xav tau.

Lorista thiab Lozap - uas yog qhov zoo dua

Cov tshuaj ua kom nquag nyob rau hauv ob qho tshuaj yeeb yog tib yam. Lawv raug kho rau cov neeg mob ntshav siab thiab mob plawv tsis xwm yeem. Txawm li cas los xij, tus nqi ntawm Lorista yog ib qho kev txiav txim ntawm qhov ntau tsawg dua li ntawm Lozap. Thawj tuaj yeem yuav tau hauv 130 rubles rau 30 ntsiav tshuaj, thiab qhov thib ob rau 280 rubles.

Txhua yam tshuaj muaj qhov zoo thiab qhov tsis zoo. Kev txheeb xyuas txog cov tshuaj Lozap tsis yog qhov tsis meej xwm no. Yuav luag txhua tus neeg mob tham txog qhov zoo ntawm cov tshuaj. Nws sai sai ceev ceev, qhov kev txhim kho zoo rau cov neeg mob lub neej. Txawm li cas los xij, cov tshuaj tsis pab txhua tus neeg. Cov kev tsis zoo hauv qab no ntawm Lozap tau sau tseg:

• tom qab noj tshuaj uas muaj cov tshuaj hu ua losartan potassium, cov neeg mob tau hnoos qhuav,
• lub xub ntiag ntawm tachycardia raug kaw,
• tinnitus
• qee hom kub siab yuav tsum ntau tshaj ib koob tshuaj,
• muaj qee qhov xwm txheej ntawm qhov tsis tsim nyog, uas yuav tsum tau txhaj tshuaj kho lossis hloov chaw siv tshuaj,
• kev txhim kho kev quav yeeb quav tshuaj yog ua tau.

Kev kos lub ntsiab lus hais txog qhov ua tau zoo ntawm cov tshuaj, nws tuaj yeem sau tseg tias nws tsis haum rau txhua tus. Tias yog vim li cas kev xaiv ntawm cov tshuaj tiv thaiv ntshav siab yuav tsum tau nqa tawm ua ke nrog tus kws kho mob koom nrog. Koj yuav tsum tsis txhob xaiv cov tshuaj no ntawm koj tus kheej, vim hais tias hloov ntawm cov txiaj ntsig uas tau tsim, koj tuaj yeem ua rau koj lub cev tsis zoo xwb.

Kwv yees tus nqi nyob rau hauv Russia

Ua raws li cov pob loj ntawm Lozap, nws cov ntau npaum li cas, thiab cov chaw tsim khoom lag luam, nws tus nqi tuaj yeem sib txawv ntawm 230-300 rubles rau ib pob. Pheej yig dua analogues yuav tsum tau xaiv nrog tus kws kho mob nkaus xwb.

Koj puas nyiam tsab xov xwm?
Cawm nws!

Tseem muaj lus nug? Nug lawv hauv cov lus!

Dosage daim ntawv.

Zaj duab xis-coated ntsiav tshuaj.

Cov khoom siv yooj yim ntawm lub cev thiab tshuaj: xim daj zoo li lub qe, cov roj-cov yeeb yaj kiab, nrog ib tus nqis siab ntawm ob sab.

Pharmacological pawg. Ua ke npaj ntawm angiotensin II inhibitors. Angiotensin II cov kev tawm tsam thiab cov kws kho mob siv. ATX code C09D A01.

Cov chaw muag tshuaj

Lozap® 100 Plus yog kev sib xyaw ua ke ntawm losartan thiab hydrochlorothiazide.Cov tshuaj ntawm cov tshuaj ua rau pom qhov ua kom zoo ntxiv, txo qis ntshav siab kom ntau dua li txhua qhov ntawm cov tshuaj tiv thaiv ib leeg. Vim yog cov nyhuv diuretic, hydrochlorothiazide nce ntshav plasma renin kev ua si (ARP), txhawb kev zais ntshis ntawm aldosterone, nce qib ntawm angiotensin II thiab txo cov qib poov tshuaj hauv ntshav cov ntshav. Txais tos ntawm losartan thaiv tag nrho cov kev mob physiological ntawm angiotensin II thiab, vim yog inhibition ntawm cov teebmeem ntawm aldosterone, pab txo qis cov poov tshuaj cuam tshuam nrog kev siv ntawm diuretics.

Losartan muaj cov nyhuv uricosuric muaj txiaj ntsig, dhau yog cov tshuaj tsis ua haujlwm ntxiv.

Hydrochlorothiazide me ntsis nce qib ntawm uric acid nyob rau hauv cov ntshav; ua ke ntawm losartan thiab hydrochlorothiazide tsis muaj zog hyperuricemia los ntawm diuretic.

Losartan yog hluavtaws angiotensin II receptor antagonist (hom AT 1 receptors) rau kev siv lub qhov ncauj.

Thaum siv losartan, qhov kev tawm tsam ntawm qhov tsis zoo rov qab tawm tsam ntawm angiotensin II ntawm kev kaw zais cia ua rau muaj kev nce ntxiv ntawm ntshav plasma renin kev ua si (ARP). Kev nce hauv ARP ua rau kev nce hauv qhov kev tso siab ntawm angiotensin II hauv ntshav ntshav. Txawm hais tias muaj kev nce ntxiv ntawm cov tshuaj no, los tiv thaiv kev ua haujlwm thiab qhov txo qis ntawm aldosterone hauv cov ntshav plasma mob siab, uas qhia tau tias muaj kev cuam tshuam zoo ntawm cov tshuaj angiotensin II. Tom qab tsis ua tiav ntawm losartan, tus nqi ntawm ARP thiab angiotensin II txo qis rau thawj theem hauv peb-hnub.

Ob leeg losartan thiab nws cov metabolite tseem ceeb muaj kev cuam tshuam zoo dua rau AO 1 receptors tshaj rau AO 2 receptors. Lub cev ua kom nquag plias yog 10-40 zaug ntau dua li losartan, thaum xam ntawm lub cev hnyav.

Raws li txoj kev tshawb nrhiav tshwj xeeb tsim los ntsuas qhov tshwm sim ntawm hnoos hauv cov neeg mob noj losartan, piv nrog cov neeg mob tau txais ACE inhibitors, qhov tshwm sim ntawm hnoos hauv cov neeg mob noj losartan lossis hydrochlorothiazide yog kwv yees li qub thiab tib lub sijhawm, cov lus ceeb toom qis dua hauv cov neeg mob noj ACE inhibitors.

Kev siv cov losartan potassium hauv cov neeg mob uas tsis muaj ntshav qab zib mellitus thiab kev txom nyem los ntawm cov hlab ntsha mob ntshav nrog proteinuria txo qib ntawm proteinuria, nrog rau kev nthuav tawm los ntawm albumin thiab IgG immunoglobulin los ntawm qhov muaj nuj nqi ntau npaum li cas.