Cov tshuaj muaj pes tsawg leeg ntawm cov tshuaj "NovoMix 30 Flexpen", tso tawm daim ntawv, taw qhia, contraindications, mechanism ntawm kev txiav txim, nqe, analogues thiab tshuaj xyuas

NovoMix 30 FlexPen yog cov tshuaj sib xyaw ua ke uas tau siv hauv kev kho mob rau mob ntshav qab zib mellitus ntawm ntau yam tshuaj pleev. Hauv tsab xov xwm peb yuav tshawb xyuas "NovoMix Penfill" - cov lus qhia rau kev siv.

Saib xyuas! Hauv kev faib tawm qhov tseeb-tshuaj-tshuaj (ATX), "NovoMix 30" yog qhia los ntawm txoj cai A10AD05. International Lub Npe Tsis Muaj Tus Kheej (INN): Insulin aspart biphasic.

Cov khoom xyaw tseem ceeb:

• Soluble (30%) insulin aspart thiab cov tshuaj muaju (70%).

Cov tshuaj tseem muaj cov neeg kis.

Pharmacodynamics thiab pharmacokinetics

NovoMix yog kev siv tshuaj tua kab mob sai sai nrog lub sijhawm ntev li 3 txog 5 teev. Novomix pib ua haujlwm yuav luag tam sim ntawd tom qab tswj hwm (hauv 10 feeb). Cov tshuaj mimics cov lus teb ntawm kev noj qab haus huv nrog zaub mov. Tam sim no, kev siv ntawm ultra-luv-ua yeeb yam insulin yog feem ntau zoo rau kev siv cov tshuaj yeeb yaj kiab luv luv, vim nws tuaj yeem siv tau tam sim ua ntej (lossis txawm tias thaum lossis tom qab) noj zaub mov. Cov tshuaj insulin txo qis cov piam thaj thiab vim li ntawd cov ntshav qab zib. Cov tshuaj Insulin inhibits gluconeogenesis thiab glycogenolysis hauv daim siab.

Lub ntsiab pharmacological zoo ntawm cov tshuaj:

• Txhim kho qhov nqus ntawm cov piam thaj hauv cov leeg nqaij thiab rog rog,
• Kev nrawm ntawm glycogen synthesis hauv cov leeg thiab mob siab,
• Kev nrawm ntawm fatty acids synthesis,
• Txhim kho cov tshuaj synthesis, piv txwv, hauv cov leeg nqaij.

Cov tshuaj muaj qhov ua haujlwm antagonistic (rov qab) rau glucagon, adrenaline, cortisol thiab lwm cov tshuaj hormones uas nce glycemia.

Novomix 30 yeej dhau nws txoj hau kev ua ntej (NovoRapid) hais txog qhov ceev ntawm qhov pib ntawm kev nqis tes, tab sis nws tseem tuaj yeem ua rau muaj ntshav nce siab ntau dua nyob hauv qhov tsis muaj tshuaj insulin-tiv thaiv mob ntshav qab zib. Cov Kev Tshawb Fawb Zaum III tam sim no coj los ntawm Dr. Keith Boehring tau pom tias cov tshuaj muaj peev xwm nce ntshav qab zib tsawg.

Cov neeg koom yog 689 cov neeg mob uas muaj ntshav qab zib hom 2 nrog kev tswj tsis tau ntshav ntshav monosaccharides, uas txuas ntxiv kom noj cov tshuaj insulin thiab tshuaj noj hauv qhov ncauj ntxiv rau cov tshuaj. Thaum siv NovoMix, cov ntshav qabzib feem ntau yuav tsum nyob qis dua li ib teev tom qab noj mov dua li noj thaum siv tshuaj insulin cais. Ntau zaus, cov neeg mob tau ntsib tus mob hypoglycemia thaum thawj ob teev tom qab noj mov, yog tias lawv noj cov tshuaj no.

Cov txiaj ntsig no tuaj yeem ua kev poob siab rau lub tuam txhab thiab tej zaum rau qee tus kws kho mob. Thaum kawg, ntau tus neeg cia siab tias yuav tau txais qhov txiaj ntsig ntawm qhov kev ua yeeb yam nrawm uas tuaj yeem kuaj pom hauv cov ntshav ncig hauv 4 feeb, uas yog li 5 feeb ua ntej thaum noj NovoRapid.

Kev taw qhia thiab contraindications

• Tsis ntev los no kuaj mob ntshav qab zib nrog glycemia ntawm 16.7 mmol / L thiab cuam tshuam hauv chaw kuaj mob,
• Cev xeeb tub
• Myocardial infarction (kev kho mob tsawg kawg 3 lub hlis tom qab pib mob plawv),
• Kev kuaj mob ntawm LADA (mob ntshav qab zib sai rau cov neeg laus)
• HbA1c (glycated hemoglobin) ntau dua 7%,
• Lub siab xav ntawm tus neeg mob.

Qhov tshwm sim uas nquag pom yog ntshav qab zib insulin. Qhov tseeb ua kom mob ntshav qab zib hom 1 tseem tsis tau paub. Ob qho tib si ib puag ncig thiab caj ces muaj koom nrog kev pib ntawm tus kabmob.

Ntawm cov ntshav qab zib ntawm daim ntawv thib ob, lub cev tuaj yeem tsim cov tshuaj hormones, tab sis nws txiav tsis ua dab tsi ntawm cov qog. Cov ntshav qab zib tsis-insulin feem ntau muaj kev pab ntev mus ntev. Nws yuav siv li ob peb xyoos kom tiav cov tshuaj tiv thaiv insulin. Thaum pib, lub cev tuaj yeem them nyiaj rau qhov txo qis ntawm cov hlwb mus rau insulin los ntawm nce nws ntau lawm. Yog tias ntshav qab zib tsis kho, nws yuav ua rau cov tshuaj insulin tsis txaus. Rau cov ntshav qab zib tsis muaj tshuaj insulin, NovoMix tau sau tseg tsuas yog thaum hloov txoj kev ua neej thiab cov tshuaj tiv thaiv kab mob hauv qhov ncauj tsis ua haujlwm.

Lub luag haujlwm tseem ceeb ntawm cov neeg mob ntshav qab zib yog qog cov kev ua ntawm lub pancreas ntau li ntau tau. Kev txhaj tshuaj rau cov neeg insulin yog nqus tau qeeb dhau los ntawm daim ntaub, vim tias cov hexamers yuav tsum xub tsim rau cov monomers kom lawv tuaj yeem nkag mus rau hauv cov hlab ntshav.

Ntawm cov ntshav qab zib hom 1, cov tshuaj tau ua ob zaug nrawm dua thiab muaj zog dua NovoRapid. Raws li cov txiaj ntsig, cov ntshav ua kom ntshav qab zib tau zoo tuaj tom qab noj mov. Txawm hais tias nws tseem tsis tau hais meej meej seb puas tau zoo tshaj plaws tom qab cov ntshav qabzib yeej tswj tau qhov muaj txiaj ntsig zoo rau kev tiv thaiv kev mob ntshav qab zib. Txawm li cas los xij, ib txoj kev tshawb fawb 2000 tawm nyob rau hauv phau ntawv xov xwm Kev Ntshav Qab Zib Kev Kho Mob pom tias kev pheej hmoo ntawm microvascular cov leeg muaj kev nyuaj siab nrog cov qab zib tom qab.

Hauv Onset2 txoj kev tshawb nrhiav, 689 cov neeg mob uas muaj ntshav qab zib hom 2 tau txais NovoMix lossis NovoRapid li ntawm 26 lub lis piam nrog zaub mov noj ua ke nrog metformin. Tsis tas li hauv qhov kev tshawb nrhiav no, qhov txo qis hauv HBA1c yog qhov zoo tib yam hauv ob pawg. Cov tshuaj tseem txo cov theem ntawm postprandial saccharides ntau ntxiv tom qab ib lossis ob teev dua li NovoRapid. Hauv ob txoj kev tshawb nrhiav, cov tshuaj tsis ua kom nce qog ntshav qab zib.

• Hypersensitivity rau cov tshuaj,
• Kev ntshav siab.

Tsuas tshuaj thiab tshaj

Raws li cov lus qhia, kev txhaj tshuaj insulin feem ntau yog ua los ntawm tus neeg mob nws tus kheej nrog tus cwj mem txhaj tshuaj. Txog qhov kawg no, tus kws kho mob thim ib lub sij hawm hauv kev sab laj nrog tus neeg mob (tseem hu ua "regimen"). Cov sijhawm qhia no siv hom tshuaj insulin twg siv thiab thaum twg yuav tsum tau siv. Koj tuaj yeem muab txhaj tshuaj (nrog rab koob) tom qab pom zoo ntawm qhov tshuaj ntawm cov tshuaj.

Lub hom phiaj yog tsim kev sim tawm cov tshuaj insulin los ntawm lub qog noj qab haus huv, nrog rau kev hloov kho cov tshuaj kom haum rau tus neeg mob lub neej. Rau qhov no, kev sib xyaw ntawm ntev lossis nruab nrab ua yeeb yam insulins, nrog rau cov neeg ua yeeb yam luv luv lossis luv luv hais, yuav luag ib txwm siv. Cov tshuaj yeeb ntev tso tawm ib zaug lossis ob zaug hauv ib hnub: lawv pab mimic lub hauv paus thiab kev tso tawm tshuaj insulin tas mus li. Ib qho tshuaj tiv thaiv ultra-luv-yeeb tshuaj yog muab rau ntau zaug hauv ib hnub, feem ntau ua ntej noj mov, kom qog cov nce ntawm cov kua tshuaj insulin tom qab noj mov.

Kev vam meej ntawm kev kho insulin mus sij hawm ntev tsis yog nyob ntawm cov tshuaj xaiv xwb, tab sis tseem muaj lwm yam - cov neeg mob siab rau kev noj haus thiab kev ua neej. Kev kho Insulin yov tshwm sim yog tias tus neeg mob (feem ntau) muaj ntshav qab zib cov ntshav uas poob rau hauv lub sijhawm xav tau. Qeb ib txwm rau cov neeg mob ntshav qab zib ntawm lub plab khoob yog 4 mmol / L, thiab tom qab noj mov - 10 mmol / L.

Kev tswj tus kheej ntawm glycemia yog ib qho tseem ceeb heev rau kev kho mob ntawm txhua yam mob ntshav qab zib. Kev tshuaj xyuas tus kheej tshwm sim los ntawm ntsuas qhov theem ntawm saccharides hauv cov ntshav. Qhov no feem ntau tau ua ib zaug lossis ob peb zaug hauv ib hnub nrog glucometer. Tus kws kho mob yuav tsum ntsuas tsis tu ncua feem pua ​​ntawm HbA1c. Raws li cov ntsuas ntsuas, nws raug nquahu kom kho cov thawj coj ntawm insulin npaj.

Kev kuaj tus kheej yog ib qho tseem ceeb rau kev kho tshuaj insulin kom tiv thaiv tau cov ntshav qog ntshav qab zib (ntshav qab zib qis dhau). Nrog rau txoj kev kho kom zoo, yuav txo tau txoj kev pheej hmoo ntawm qog ntshav yuav txo tau xoom. Kev mob ntshav qab zib feem ntau tsis yog tsuas yog cuam tshuam nkaus xwb, tab sis kuj tseem muaj kev pheej hmoo ua lub neej.

Kev sib txuam

Cov tshuaj tuaj yeem cuam tshuam nrog txhua yam tshuaj uas cuam tshuam rau glycemia ncaj qha lossis tsis ncaj.

Lub tswv yim ntawm tus kws kho mob thiab tus neeg mob.

Cov tshuaj yuav siv tau ua ntej noj tshais, noj su lossis ua hmo. NovoMix, raws li kev tshawb fawb, muaj kev txo qis tom qab cov ntsiab lus ntawm monosaccharides hauv cov hlab ntshav. Tsuas tshuaj yuav tsum pom zoo nrog kws kho mob.

Boris Alexandrovich, mob ntshav qab zib

Kuv tswj cov tshuaj ua ntej noj hmo. Raws li ntsuas 'meter', cov tshuaj txo cov suab thaj zoo. Kuv tsis pom qhov tsis zoo.