Yuav siv cov tshuaj amitriptyline li cas? > Kev khomob thiab kev tiv thaiv

Amitriptyline

Tshuaj lom neeg cov khoom sib txuas
IUPAC	5- (3-Dimethylaminopropylidene) -10,11-dihydrodibenzocycloheptene
Cov piav suav	C₂₀H₂₃N
Molar loj	277,403 g / mol
Cas	50-48-6
PubChem	2160
Tshuajqauj Tshuaj	APRD00227
Kev faib tawm
ATX	N06AA09
Cov Tshuaj Pharmacokinetics
Bioav Tseem Muaj	30—60 %
Kev zom zaub mov	Lub siab
Ib nrab-lub neej.	10-26 h
Kev cais tawm	Lub raum
Dosage Cov Ntawv
ntsiav tshuaj (dragees) 10, 25, 50, 75 mg, retard tsiav tshuaj 50 mg, 1% daws hauv ampoules, 2 ml.
Tus thawj coj kev tswj hwm
sab hauv, intramuscularly, tso leeg (kua)
Lwm lub npe
Amitriptyline, Amizol, Amirol, Saroten Retard, Triptisol, Elivel, Amineurin, Apo-Amitriptyline, Novo-Triptin, Adepren
Cov Ntaub Ntawv Wikimedia Commons Media Files

Amitriptyline (lat. Amitriptylinum) - ib qho ntawm cov neeg sawv cev tseem ceeb ntawm tricyclic antidepressants, nrog rau imipramine thiab clomipramine. Amitriptyline yog ib cov tshuaj feem ntau siv los kho ntau tus mob hlwb: kev nyuaj siab thiab ntxhov siab, tsis tshua pom tshwm, muaj kev cuam tshuam tsis zoo hyperactivity tsis meej thiab bipolar tsis meej. Lwm qhov kev qhia muaj xws li mob taub hau prophylaxis, kev kho mob ntawm neuropathic mob xws li mob fibromyalgia thiab postherpetic neuralgia, thiab feem ntau tsis tshua muaj neeg tsis tsaug zog. Cov tshuaj yog rau cov chav kawm ntawm tricyclic antidepressants (TCAs), thiab nws lub tshuab muaj tseeb ntawm kev ua haujlwm tsis meej. Amitriptyline yog muab rau qhov ncauj thiab ua ib qho kev txhaj tshuaj.

Cov kev mob tshwm sim lub ntsiab yog qhov pom kev plooj plooj, qhov ncauj qhuav, ntshav siab thaum sawv ntsug, tsaug zog, thiab cem quav. Cov kev mob tshwm sim hnyav tuaj yeem suav nrog ua kom qaug dab peg, muaj kev pheej hmoo ntau tus kheej tua tus kheej hauv cov neeg hnub nyoog qis dua 25 xyoos, kev tso zis cia, lub ntsej muag daj, thiab lub siab. Amitriptyline yuav tsum tsis txhob noj nrog MAO inhibitors lossis nrog tshuaj cisapride. Amitriptyline tuaj yeem ua rau muaj kev phom sij yog tias noj thaum cev xeeb tub. Siv thaum lub sijhawm pub mis rau menyuam zoo nkaus li nyab xeeb.

Amitriptyline tau tshawb pom xyoo 1960 thiab tau pom zoo los ntawm U.S. Food and Drug Administration (FDA) xyoo 1961. Nws muaj muaj raws li cov tshuaj feem ntau.

Timoanaleptic (antidepressant) nyhuv yog ua ke nrog cov lus tshaj tawm sedative, hypnotic thiab anxiolytic (tiv thaiv kev ntxhov siab) vim yog cov tshuaj tiv thaiv muaj zog anticholinergic thiab antihistamine. Lub sijhawm tam sim no, amitriptyline yog suav hais tias yog tus ntseeg siab tshaj plaws. lub hauv paus? thiab ib qho tricyclic cov tshuaj tiv thaiv pheej yig heev. Hauv cov npe ntawm cov tshuaj pom zoo los ntawm World Health Organization.

Kho mob siv

Nws yog ib qho inhibitor ntawm neuronal reuptake ntawm mediator monoamines, suav nrog norepinephrine, dopamine, serotonin, thiab lwm yam Nws tsis ua rau MAO kev cuam tshuam.

Tseem ceeb M-cholinolytic (anticholinergic), antihistamine, thiab alpha-adrenolytic kev ua yog yam ntxwv. Txawm li cas los xij, amitriptyline tsis yog tag nrho cov kev cuam tshuam ntawm lub zog, kev xav ntawm lub hlwb. Qhov kev hloov tawm tshwj xeeb tshaj tawm tshwj xeeb tshaj tawm nyob rau hauv qee qhov kev txiav txim siab (rau txhua tus neeg mob, lub caij nyoog no yog ib tus neeg) thiab muaj feem cuam tshuam nrog kev nce siab ntawm lub ntsiab ntawm cov metabolite ntawm amitriptyline, nortriptyline, nrog rau qhov tawm suab thiab lub siab-energizing nyhuv, ib feem nrog cov tshuaj tiv thaiv kab mob thiab txhawb cov nyhuv ntawm amitriptyline nws tus kheej. Thaum txoj kev txwv siab tshaj ntawm "qhov rai" ntawm cov tshuaj tiv thaiv tau dhau lawm, qhov ua kom loog ntawm amitriptyline rov pib muaj, thiab qhov pom tshwm sim (thiab qee zaum antidepressant) cuam tshuam tsis muaj zog. Ntawm cov koob tshuaj qis, qis dua qee tus neeg "tiv thaiv kev nyuaj siab kho qhov tsis zoo," tsis muaj qhov txhawb los yog tshuaj tiv thaiv kev nyuaj siab - pom tsuas yog tsis muaj qhov ua kom loog, hypnotic thiab tiv thaiv kev ntxhov siab.

Los ntawm lub zog ntawm kev ua kom loog, hypnotic thiab tawm tsam qhov cuam tshuam, amitriptyline nyob rau hauv chav kawm ntawm tricyclics yog qis dua tsuas yog rau trimipramine thiab fluoroacisin, thiab los ntawm lub zog ntawm cov nyhuv stimulating thiab psychoenergetic nws yog qis dua rau clomipramine, imipramine thiab tricyclics ntawm pawg me me ntawm sab qaum teb,,. Ntawd yog, amitriptyline ze dua rau "sedative" qhov kawg ntawm lub teeb ntawm tricyclics, tab sis tsis yog qhov kawg ntawm lub spectrum.

Thov hauv tshuaj kho |Daim ntawv tso tawm

Muaj ob daim ntawv ntawm kev tso tawm cov tshuaj - cov ntsiav tshuaj thiab ib txoj kev daws teebmeem rau kev tswj hwm hauv tsoomfwv. Muaj cov ntsiav tshuaj nrog qhov ntau npaum ntawm 10, 25 thiab 50 mg. 1 ml ntawm cov tshuaj muaj 10 mg ntawm amitriptyline. Cov tshuaj yuav muab faib tawm los ntawm cov kws kho mob sau.

Cov qauv ua piv txwv ntawm amitriptyline yog:

Ntxiv rau, muaj lwm cov tshuaj tiv thaiv kab mob. Cov pab pawg ntawm tricyclic antidepressants tseem suav nrog imipramine thiab clomipramine. Txawm li cas los xij, ntawm chav kawm, xaiv txoj kev kho kom zoo rau kev tiv thaiv kev ntxhov siab yog qhov tseem ceeb ntawm tus kws kho mob hlwb, kws kho paj hlwb lossis tus kws kho hlwb, thiab kev siv tus kheej yog qhov tsis tsim nyog thiab txawm tias txaus ntshai ntawm no.

Cov Yuav Tsum Muaj

Amitriptyline yog contraindicated nyob rau hauv:

cov qauv mob hnyav rau lub plawv thiab raum tsis ua haujlwm,
decompensated lub plawv tsis xws luag,
ntshav siab,
mob los yog subacute cov ntaub ntawv ntawm myocardial infarction,
qaug cawv nrog haus cawv, noj pw tsaug zog, ua kom loog thiab puas hlwb,
lub kaum ntse ntse ntsej muag
atrioventricular block 2 tbsp;
tsis txog 6 xyoo
thaum noj MAO inhibitors.

Thaum cev xeeb tub, kev noj cov tshuaj tuaj yeem tsuas yog kho lub sijhawm tsis muaj lwm txoj hauv kev, tom qab tus kws kho mob tsaj qhov zoo thiab tsis zoo. Raws li pom los ntawm kev sim rau tsiaj, cov tshuaj muaj cov teratogenic effect. Cov menyuam mos yug los ntawm cov poj niam noj cov tshuaj thaum cev xeeb tub yuav muaj kev nkees nkees lossis tsim kua muag rau qee lub sijhawm. Tsis tas li, cov tshuaj tsis raug tso cai thaum lub sijhawm lactation vim nws lub peev xwm nkag mus rau hauv niam mis. Cov menyuam yaus ntawm leej niam uas noj niam mis noj cov tshuaj amitriptyline kuj tuaj yeem yuav lub cev tsaug zog.

Cov tshuaj, ntxiv rau, yog contraindicated rau cov neeg tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev kub siab.

Cov tshuaj yog tshuaj nrog ceev faj nyob rau hauv:

muaj teeb meem nrog cov hlab plawv (tshwj xeeb, mob hlab ntsha plawv, tsis xwm yeem, lub plawv tsis ua haujlwm),
haus cawv ntev zuj zus
bronchial hawb pob,
tsawg plab hnyuv lub cev muaj zog muaj nuj nqi,
keeb kwm ntawm cov kev mob tshwm sim,
kev nyuaj siab manic,
tus mob stroke
lub raum thiab hepatic pathologies,
tso zis cia thiab zais zis hypotension,
thyrotoxicosis,
qaug dab peg
prostatic hyperplasia.

Kev kho mob ntawm cov neeg mob uas muaj kev nyuaj siab endogenous thiab muaj kev pheej hmoo siab ntawm tus kheej txoj kev tua tus kheej yuav tsum tau nqa tawm hauv tsev kho mob nkaus xwb.

Sab sij huam

Feem ntau cov kev phiv uas tsis tshwm sim uas tshwm sim los ntawm kev noj cov tshuaj muaj xws li:

tsaug zog lossis pw tsaug zog,
mob taub hau
kiv taub hau
kev ua xua (tawv nqaij - urticaria, tawm pob lossis khaus, lossis kaw lus - anaphylactic poob siab, Quincke's edema),
mob plab, xeev siab, raws plab, cem quav,
jumps hauv cov ntshav siab (feem ntau feem ntau hypotension, vim lub alpha-thaiv cov nyhuv ntawm cov tshuaj),
siab poob thaum sawv los yog txav lub cev los ntawm kev dag mus rau qhov chaw zaum (orthostatic hypotension),
arrhythmias
nce siab intraocular.

Hauv kev siv rab phom sij, kev siv tshuaj amitriptyline hauv koob tshuaj siab dua 150 mg rau ib hnub tuaj yeem ua rau txo qis qhov qaug dab peg. Thaum siv rau hauv cov menyuam yaus thiab cov tub ntxhais hluas txog 24 xyoos, nws tuaj yeem nce qhov kev pheej hmoo ntawm tus kheej txoj sia. Ntev siv ntev ua rau muaj qhov caries ntau.

Los ntawm ib sab ntawm lub hauv nruab nrab cov hlab hlwb kuj tuaj yeem pom:

tsaus muag
tinnitus
nce siab txob taus
kev tsis zoo
ntxhov siab
lus txhais
kev loj hlob ntawm mania,
nco qab tsis zoo
lub cev muaj zog kev ntxhov siab
nce chua leeg,
qaug dab peg,
kev cuam tshuam ntawm cov leeg tshwj xeeb
tsis muaj peev xwm mloog zoo,
npau suav phem.

Kev ua xyem xyav yog yam ntxwv zoo dua rau cov laus thiab cov neeg mob Parkinson tus kab mob.

Cov tsos mob ntawm qaug dab peg feem ntau feem ntau nws tus kheej thaum noj tshuaj hauv qhov siab, hauv cov neeg mob qaug dab peg lossis cov neeg mob uas muaj keeb kwm mob craniocerebral. Hauv cov xwm txheej zoo li no, yuav tsum tau kho kho dua ib koob lossis tswj hwm cov tshuaj anticonvulsants.

Los ntawm cov hlab plawv system kuj ua tau:

mob raum tsis meej
cov kev hloov pauv QT ncua nyob ntawm ECG (xav kom txo qhov koob tshuaj lossis kev soj ntsuam tas li ntawm qhov ntsuas),
tachycardia
palpitations.

Phiv los ntawm anticholinergic ua:

qhov ncauj qhuav
dilated cov tub ntxhais kawm
ua txhaum ntawm kev pab (qhov muag plooj),
kev tso zis cia
anticholinergic intoxication,
plab hnyuv ob leeg (feem ntau yog rau cov neeg laus thiab cov neeg mob uas nyiam tawv ncauj).

Los ntawm lub plab zom mov kuj tseem ua tau:

kev loj hlob ntawm kab mob siab thiab daj,
Kev mob siab
nce qab los noj mov (feem ntau yog siv tshuaj yaj yeeb, ntawm qhov tsis sib xws, ua rau txo qis qhov qab los noj mov),

Los ntawm cov kab ke endocrine, cov xwm txheej hauv qab no muaj peev xwm ua tau:

testicular edema,
gynecomastia (ntxiv mis, hauv poj niam thiab txiv neej),
poob qis los yog muaj zog libido,
hloov pauv ntawm potency.

Cov kev mob tshwm sim hauv qab no tsis suav tias:

plaub hau poob
mob plab
darkening ntawm tus nplaig,
o tuaj
o cov qog ntshav o
tes tshee tshee (cuam tshuam nrog kev txhawb nqa lub cev-beta-adrenergic system, muaj txiaj ntsig los ntawm kev noj beta-blockers),
kev hloov pauv hauv cov ntshav sib txuam (leukopenia, eosinophilia, thrombocytopenia), hloov pauv ntawm cov piam thaj hauv cov ntshav.

Thaum koj thim cov tshuaj, cov xwm txheej hauv qab no yog qhov ua tau:

mob taub hau
kev zoo siab
dav malaise
zawv plab
lub cev muaj zog kev ntxhov siab
txob taus.

Yog li no, ua ntej yuav tsum txiav tawm cov tshuaj, yuav tsum maj mam txo qhov tshuaj me me. Cov tsos mob no feem ntau yog hloov thiab tsis muaj pov thawj ntawm kev quav tshuaj.

Cov lus qhia rau kev siv

Thawj koob tshuaj hauv cov ntsiav tshuaj yog 25-50 mg (1-2 ntsiav tshuaj 25 mg) ib hnub. Hauv qhov no, cov tshuaj zoo dua rau noj ua ntej mus pw. Tom qab ntawd qhov koob tau nce zuj zus (txhua hnub 25 mg) txog 150-200 mg. Hauv qhov no, koob tshuaj txhua hnub yuav tsum tau muab faib ua peb zaug. Qhov loj tshaj plaws ntawm cov tshuaj yuav tsum tau noj thaum hmo ntuj.

Hauv qee qhov mob me, hauv cov neeg mob noj cov tshuaj thawj zaug, hauv cov neeg mob uas muaj tus kab mob somatic hnyav, hauv cov neeg laus lossis cov neeg hluas, qhov nce qeeb qeeb yog pom zoo (25 mg hauv 2-3 hnub). Hauv kev hnyav, suicidally txaus ntshai kev nyuaj siab, ntawm qhov tsis tooj, koj yuav tsum pib tam sim ntawd nrog cov tshuaj txhua hnub loj (100 mg).

Qhov siab tshaj plaws ib hnub rau kev kho mob sab nrauv yog 200 mg, rau kev kho mob hauv tsev kho mob - 300 mg. Qee qhov xwm txheej, nrog kev nyuaj siab thiab ua siab ntev rau cov tshuaj, nws muaj peev xwm nce qhov siab tshaj plaws qhov kev noj tshuaj txhua hnub rau 400-450 g.

Hauv kev kuaj mob bulimia nervosa, cov kev xav hauv lub cev, schizophrenia, hnyav los ntawm kev mob hlwb, kev haus cawv pib nrog ib koob tshuaj 25-100 mg (1-4 ntsiav tshuaj 25 mg) thaum tsaus ntuj. Tom qab ncav cuag kev kho mob kom zoo, nws yog ib qho tsim nyog yuav tsum hloov mus rau qhov siv tshuaj tsawg kawg - 10-50 mg ib hnub.

Kev tiv thaiv ntawm kev mob taub hau, mob neurogenic mob, lub plab zom mov yuav tsum tau txhaj tshuaj txhua hnub ntawm 10-100 mg (qhov koob tshuaj yog kws kho mob sau tseg raws li qee yam). Ntxiv mus, feem ntau ntawm cov koob tshuaj yog noj thaum hmo ntuj.

Hauv kev kho mob ntawm kev mob siab rau cov menyuam yaus 6-12 xyoo, nws yog ib qho tsim nyog yuav tau noj cov tshuaj ntawm 10-30 mg ib hnub twg. Lossis koj tuaj yeem suav qhov ntau npaum li cas raws li qhov hnyav ntawm 1.5 mg / kg.

Nrog rau cov nocturnal enuresis hauv cov menyuam yaus 6-12 xyoo, 10 mg yog cov tshuaj, feem ntau tsawg dua 20 mg. Cov menyuam yaus hnub nyoog dhau 12 xyoos - txog 50 mg. Cov tshuaj tau coj ib zaug thaum hmo ntuj.

Lub sijhawm kho yog nyob ntawm ntau yam - tus mob ntawm tus neeg mob, hom kabmob, thiab tuaj yeem sib txawv ntawm ob peb lub hlis mus rau ib xyoos.

Yog tias lub raum tsis ua haujlwm lawm, yuav tsum tau txhaj tshuaj. Koob tshuaj yuav tau yauv kho cov laus.

Txhawm rau kom tsis txhob phiv tshuaj, cov tshuaj yuav tsum tau noj tam sim ntawd tom qab noj mov.

Nrog kev tshem tawm sai ntawm cov tshuaj, ib qho kev tshem tawm tus mob yuav tshwm sim. Yog li, nws raug nquahu kom maj mam txo qhov ntau ntawm cov tshuaj ua ntej thaum kawg ntawm kev kawm.

Noj ntau dhau

Nyob rau hauv cov ntaub ntawv ntawm overdose, cov hauv qab no yog ua tau:

neeg ruam
nce toj zog nkees
coma
kev zoo siab
tsis meej pem,
kev tsis zoo
ntuav
kev nyuaj siab mob ntsws
tachycardia
siab poob
arrhythmias
txog siav.

Nws yog tsim nyog pais plab lav, kev kho mob yam ntxwv. Hemodialysis tsis muaj txiaj ntsig.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj tsis sib xws nrog cawv. Yog li, hauv kev kawm thaum kho, nws yog qhov tsim nyog kom tso dej cawv. Koj yuav tsum tsis txhob noj cov tshuaj nrog lwm tricyclic cov tshuaj tiv thaiv kev ntxhov siab. Kev siv ntawm ib pawg ntawm cov xaiv serotonin reuptake inhibitors nrog cov tshuaj tiv thaiv kev puas tsuaj tuaj yeem ua rau serotonin syndrome.

Nws yog kiag li tsis sib xws nrog lwm chav kawm ntawm kev tiv thaiv kev nyuaj siab - MAO inhibitors. Nrog rau kev siv thooj txhij nrog MAO inhibitors, kev mob hnyav thiab cov teeb meem kub siab tuaj yeem tshwm sim, uas feem ntau xaus rau kev tuag ntawm tus neeg mob. Yog li, qhov luv nruab nrab ntawm cov chav kawm ntawm kev kho mob nrog amitriptyline thiab MAO inhibitors yuav tsum yog tsawg kawg 2 lub lis piam.

Nrog rau kev tswj hwm tib lub sijhawm nrog benzodiazepines, kev sib txuam sib luag ntawm kev ua kom muaj txiaj ntsig zoo yuav raug pom. Thaum siv nrog lwm cov tshuaj tiv thaiv kab mob tsis haum tshuaj, barbiturates, sedatives, benzodiazepines, kev siv tshuaj loog, qhov cuam tshuam rau lub hauv nruab nrab cov hlab ntsha nce, cov nyhuv hypotensive nthuav dav, kev mob ntsws ua pa tau.

Amitriptyline tseem txhim kho cov nyhuv ntawm cov hlab plawv system ntawm epinephrine, ephedrine, thiab zoo li, uas ua rau muaj kev pheej hmoo ntawm tachycardia, arrhythmias, thiab mob ntshav siab. Yog li, thaum ua kom loog (tshuaj loog ib txwm muaj xws li epinephrine), tus kws kho mob yuav tsum paub txog tus neeg mob noj cov tshuaj tiv thaiv kab mob siab li no txhawm rau kho lub koob tshuaj loog.

Nce kho kho qhov mob tshwm sim ntawm anticholinergic, antihistamines, uas tuaj yeem ua rau muaj kev mob tshwm sim ntxiv. Amantadine tsub kom cov nyhuv anticholinergic ntau ntxiv.

Cov tshuaj txo cov hauj lwm zoo ntawm alpha-blockers, anticonvulsants thiab antihypertensive tshuaj. Clonidine thiab antihistamines nce inhibitory nyhuv rau nruab nrab lub paj hlwb, atropine nce txoj kev pheej hmoo ntawm txoj hnyuv tuag tes tuag taw. Tib lub sijhawm, clonidine thiab methyldopa txo cov nyhuv hypotensive.

Barbiturates, nicotine txo qis cov nyhuv ntawm cov tshuaj. Cocaine tsub kom muaj kev pheej hmoo ntawm arrhythmias. Local adrenomimetics nce vasoconstrictor siv. Kev siv cov thyroid cov tshuaj hormones nrog rau cov tshuaj nce ntxiv ntawm ob leeg sib cuam tshuam rau kev kho mob thiab tshuaj lom.

Cov lus piav qhia ntawm cov lus qhia rau kev siv amitriptyline

Amitriptyline yog cov tshuaj los ntawm pawg ntawm tricyclic antidepressants. Ntxiv nrog rau qhov cuam tshuam loj, nws muaj cov nyhuv analgesic, pab kev kho mob ntawm cov txaj pw.

Amitriptyline yog tsim los ntawm ntau cov tuam ntxhab - domestic Veropharm, ALSI Pharma, ntxiv rau txawv teb chaws - Grindex, Nycomed, nyob hauv ntau cov npe lag luam:

Amitriptyline belongs rau cov tshuaj tiv thaiv kev ntxhov siab. Nws cov txiaj ntsig tag nrho yog: C20H23N.Lub Npe Tsis Txhim Kho Thoob Ntiaj Teb (INN) yog amitriptyline.

Tso cov ntaub ntawv thiab cov nyob ua ke

Amitriptyline muaj nyob rau hauv ob daim ntawv ntau npaum li cas - ntsiav tshuaj thiab kev daws teeb meem.

Cov ntsiav tshuaj ntawm 10 thiab 25 mg rau siv sab hauv. 50 thiab 100 daim tau ntim rau hauv pob contour.
Ib qho tshuaj tov ntawm 10 mg / ml, 2 ml ampoules rau kev tso quav thiab intramuscular. Hauv pob ntawm 10 daim.

Cov ntsiav tshuaj muaj 10 lossis 25 mg ntawm cov tshuaj nquag - amitriptyline hydrochloride. Cov tshuaj ntxiv (ua tsis tiav) yog microcrystalline cellulose, talc, lactose monohydrate, silicon dioxide, magnesium stearate, pregelatinized hmoov txhuv nplej siab.

Cov tshuaj muaj pes tsawg leeg ntawm cov tshuaj "Amitriptyline" hauv kev daws teeb meem suav nrog 10 mg ntawm cov tshuaj nquag thiab ntxiv - hydrochloric (hydrochloric) acid, benzetonium thiab sodium chloride, dextrose monohydrate, dej rau infusion.

Pharmacological kev txiav txim

Cov tshuaj rau cov tshuaj tiv thaiv muaj zog. Tus txheej txheem ntawm kev ua ntawm amitriptyline ntawm lub cev yog ib qho kev nce siab ntawm norepinephrine nyob rau hauv synapses thiab serotonin hauv cov hlab hlwb (lawv qhov kev thim rov qab txo qis). Nrog rau kev kho mob ntev, cov kev ua haujlwm ntawm beta-2 adrenergic zoo li cov serotonin receptors hauv lub hlwb txo qis. Nws muaj cov lus tshaj tawm anticholinergic (nruab nrab thiab ntu ntu).

Amitriptyline ua haujlwm li cas hauv kev nyuaj siab? - txhim kho mus ob peb vas, txo psychomotor ntxhov siab, ntxhov siab vim, pw tsaug zog zoo li qub. Lub antidepressant nyhuv ntawm cov tshuaj manifests nws tus kheej 2-3 lub lis piam tom qab pib ntawm kev coj.

Ntxiv rau cov tshuaj tiv thaiv kev ntxhov siab, cov tshuaj muaj tus lej ntawm lwm yam kev ua.

Cov tshuaj tiv thaiv tau cuam tshuam nrog thaiv cov histamine receptors hauv lub plab zom mov.
Tsis qab los noj mov.
Kev nce ntxiv ntawm lub peev xwm ntawm lub zais zis ncab thiab nce ntxiv ntawm lub suab ntawm nws qhov taub, raws li qhov txo qis hauv kev ua ntawm serotonin thiab acetylcholine receptors.
Yog tias kev npaj tshuaj loog yog npaj, ces nws yog qhov yuav tsum ceeb toom rau tus kws kho mob txog kev noj cov tshuaj no, vim tias nws txo qis ntshav siab thiab lub cev qhov kub.
Tshem tawm qhov mob. Thaum twg amitriptyline pib pab mob mob? - raws li cov neeg kuaj mob, twb tau kho mob tau 2-3 hnub.
Tshem tawm ntawm lub txaj pw.

Kev ntsuas rau siv

Cov npe ntawm cov cim qhia tau dav dav, tab sis vim li cas tseem ceeb rau kev teem caij ntawm amitriptyline yog kev nyuaj siab mob ntawm ntau lub hauv paus pib.

Dab tsi pab amitriptyline?

Kev nyuaj siab - kev ua tsis taus, endogenous, neurotic, nti tshuaj, tshuaj, tawm tsam yav dhau los ntawm kev haus cawv haus cawv, ua rau cov paj hlwb hauv lub hlwb. Tshwj xeeb tshwm sim nrog kev ntxhov siab, pw tsaug zog.
Kev xav txawv ntawm lub cev sib xyaw. Amitriptyline tuaj yeem tsim kev kub ntxhov.
Cov paj hlwb nyob rau tom qab ntawm schizophrenia, haus dej cawv haus cawv.
Kev coj cwj pwm tsis zoo (hloov hauv kev saib xyuas thiab kev ua si).
Enuresis thaum tsaus ntuj.
Mob mob ntsws - mob oncological, mob rheumatic, postherpetic neuralgia, mob tom qab.
Bulimia leeg.
Kev Tiv Thaiv Mob Yig Yeem
Qhov txhab mob txhab ntawm lub plab zom mov.

Kev qhia rau kev siv cov ntsiav tshuaj thiab Amitriptyline daws yog cov zoo sib xws.

Kev siv cov ntsiav tshuaj

Koj puas xav tau haus amitriptyline ua ntej lossis tom qab noj mov? Cov ntsiav tshuaj tau noj tom qab noj mov, uas tsis tau ntxo ua ntej, txhawm rau txo qhov tsis zoo nyob rau ntawm lub plab.

Cov tshuaj noj hauv qab no tau qhia hauv cov lus qhia rau kev siv ntawm cov tshuaj amitriptyline.

Kho cov teeb meem ntxhov siab. Thawj qhov tshuaj yog 25-50 mg thaum tsaus ntuj. Tom qab ntawd nce maj, tshaj 5 hnub rau 200 mg ib hnub twg, faib ua 3 koob. Yog tias qhov kev kho mob tsis tshwm sim hauv 2 lub lis piam, qhov koob tshuaj txhua hnub yog nce mus txog qhov siab tshaj plaws - 300 mg.
Kev kho mob taub hau, mob tob hau, mob mob ntev. Kev kho tshuaj yog 12,5-100 mg rau ib hnub, qhov nruab nrab yog 25 mg. Yuav ua li cas noj tshuaj amitriptyline rau mob taub hau thiab lwm yam mob? - ib zaug, thaum tsaus ntuj.
Kev noj tshuaj ntawm Amitriptyline ntsiav tshuaj hauv lwm yam mob yog xaiv tau ib tus zuj zus.

Yuav ua li cas noj amitriptyline thaum tsaus ntuj nrog insomnia? Yog tias muaj kev pw tsaug zog tawm tsam keeb kwm ntawm kev ntxhov siab, tom qab ntawd qhov no tsis tas yuav muaj kev hloov pauv ntawm cov qauv txheej txheem, cov tshuaj tau noj raws li tau piav saum toj no.

Cev xeeb tub thiab lactation

Cov tshuaj yog pawg C ntawm qhov kev txiav txim ntawm tus me nyuam raws li FDA kev faib tawm (hauv kev tshawb xyuas tsiaj, muaj cov txiaj ntsig tsis zoo). Yog li, kev teem sijhawm ntawm amitriptyline thaum cev xeeb tub yog qhov tsis xav tau. Nws tsuas yog siv yog tias qhov txiaj ntsig xav tau rau leej niam ntau dua qhov phom sij rau lub cev xeeb tub.

Thaum cov tshuaj raug xaj thaum lactation, tom qab ntawd tag nrho cov chav kho mob yuav tsum tsis pub mis niam.

Siv rau thaum yau

Amitriptyline yog tsim rau cov menyuam yaus los kho lub txaj pw:

ntsiav tshuaj - los ntawm rau xyoo,
daws - los ntawm kaum ob.

Nws tsis tshua muaj qhov kev txiav txim siab muaj menyuam yaus rau kev kho mob ntawm qhov tsis xav tau. Hauv qhov xwm txheej no, cov koob tshuaj, ntau zaus thiab lub sijhawm kho tau xaiv ib tus zuj zus.

Amitriptyline raug noj rau cov menyuam uas muaj kev nyuaj siab li cas? - muab raws li nram no:

thaum muaj hnub nyoog 6 mus txog 12 xyoo - 10-30 mg ib hnub lossis 1-5 mg / kg,
cov tub ntxhais hluas txij 12 xyoo - txog 100 mg.

Nrog nocturnal enuresis:

cov menyuam yaus hnub nyoog 6 mus txog 10 xyoo 10-20 mg ib hnub twg thaum tsaus ntuj,
cov tub ntxhais hluas hnub nyoog 11-16 xyoo - txog 50 mg ib hnub twg.

Siv rau lub sijhawm qub

Hauv lub hnub nyoog laus, nws tau tsuas yog kho rau mob me me ntawm kev ntshaus siab, bulimia nervosa, kev sib xyaw ntawm kev xav, kev xav ntawm lub hlwb schizophrenia thiab haus cawv haus cawv.

Yuav ua li cas noj amitriptyline rau cov neeg laus? Ntawm ib koob tshuaj 25-100 mg thaum tsaus ntuj, ib zaug. Tom qab ua tiav txoj kev kho kom zoo dua, txo qhov kom tsawg dua 10-50 mg rau ib hnub.

Sab sij huam thiab teeb meem

Cov kev mob tshwm sim ntawm amitriptyline tshwm sim ntau heev thiab tuaj yeem tawm suab thiaj li tshaj li cov txiaj ntsig kho tau ntawm kev kho mob. Hauv qhov no, kev txiav txim siab ntawm lub sijhawm teem tseg yog ib txwm ua tib zoo, thiab cov neeg mob thiab lawv tsev neeg yuav tsum ntsuas lawv tus mob thaum kho.

Phiv los cuam tshuam nrog anticholinergic kev txiav txim:

qhov muag plooj, pom cov tub kawm ntawv, kev ua kom tuag tes tuag taw, nce siab ntawm cov tib neeg, muaj lub qhov nqaim ntawm chav nyob sab xub ntiag ntawm lub qhov muag,
qhov ncauj qhuav
tsis meej pem,
cem quav, tuag tes tuag taw txoj hnyuv tawm tsam,
teeb meem tso zis.

Phiv los ntawm lub hauv nruab nrab hauv lub paj hlwb:

tsaus muag
tsaug zog
siab rog
txob taus
nco qab tsis zoo
disorientation nyob rau hauv qhov chaw,
ntxhov siab, ntxhov siab,
kev saib xyuas tus kheej (feem ntau hauv cov neeg laus thiab cov neeg uas muaj tus kab mob Parkinson),
psychomotor ntxhov siab,
mania, as Well as hypomania,
tsawg dua mloog nrog,
pw tsaug zog
npau suav phem
asthenia
muaj mob taub hau, tshee tshee, nce qaug dab peg, dysarthria, paresthesia, myasthenia gravis, ataxia, ntxiv rau cov leeg mob sypyfidal.

Txog lub plawv mob:

tachycardia
arrhythmia,
orthostatic hypotension,
ECG pauv hloov hauv cov neeg mob uas tsis muaj mob plawv,
dhia hauv ntshav siab,
ua txhaum ntawm intraventricular conduction.

Los ntawm cov hnyuv:

Kev mob siab
xeev siab
mob plab
ntuav
kab mob siab
nce qab los noj mov
Kev rog rog lossis poob phaus,
saj hloov
mob plab
zawv plab
darkening ntawm tus nplaig.

Los ntawm cov kab ke endocrine:

testicular edema
o mis rau cov txiv neej,
txo lossis nce siab hauv libido,
potency teeb meem
nce lossis txo qis hauv cov ntshav qab zib,
tsawg dua cov vasopressin ntau lawm.

khaus
daim tawv nqaij ua pob, urticaria,
angioedema (Quincke),
kev saib duab.

Lwm cov kev phiv:

tinnitus
plaub hau poob
edema
npaws
o cov qog ntshav o
kev tso zis cia.

Cov lus qhia tshwj xeeb

Ua tib zoo saib xyuas qhov ntsuas mob hnyav thiab cuam tshuam qhov kev pheej hmoo ntawm kev tsim kev phiv tshuaj nrog cov txiaj ntsig ntawm kev kho mob.

Nws ua pov thawj tias hauv cov menyuam yaus, cov hluas thiab cov neeg hauv qab 24 xyoo muaj kev txom nyem los ntawm kev nyuaj siab thiab kev puas siab puas ntsws, cov tshuaj tsub ntxiv qhov kev xav tua tus kheej thiab tus cwj pwm. Yog li, kev teem sij hawm ntawm amitriptyline hauv pawg no ntawm cov neeg mob yuav tsum tau tsim nyog!
Hauv cov neeg laus laus, kev kho mob tuaj yeem ua rau muaj kev puas siab ntsws ntawm yeeb tshuaj hlwb thaum tsaus ntuj. Tom qab tsis ua tiav ntawm cov tshuaj, tus mob no yuav nyob ntev li ob peb hnub.
Hauv cov neeg mob uas muaj ntshav tsis txaus ntseeg, cov cim no yuav tsum tau saib xyuas lub sijhawm kho. Nws yuav txo qis lossis nce ntxiv.
Nws raug nquahu kom tsis txhob muaj kev qoj ib ce - ua tib zoo tsiv mus rau txoj hauj lwm ntsug los ntawm kab rov tav, vim tias kiv taub hau thiab ploj mus ntawm txoj kev tuaj yeem yuav tshwm sim.
Kev siv cawv thiab tshuaj yeeb uas muaj ethanol raug txwv rau tag nrho lub sijhawm kho!
Yog tias kev kho mob nrog MAO inhibitors tau nqa tawm, amitriptyline yog tus kws kho mob tsis pub dhau 14 hnub tom qab lawv tshem tawm.
Ib koob tshuaj ntau dua 150 mg rau ib hnub ua rau kev txo qis rau qhov kev ua rau qaug dab peg thiab nce kev pheej hmoo ntawm qaug dab peg hauv cov neeg tsis haum thiab cov neeg mob vwm.
Nrog kev nyuaj siab ntau, qhov kev pheej hmoo ntawm kev tua tus kheej yog ib txwm muaj siab, yog li ntawd, thaum pib ntawm txoj kev kho mob, kev coj ua ke ntawm benzodiazepines lossis antipsychotics raug pom zoo.
Hauv cov neeg mob uas raug mob los ntawm kev cuam tshuam txog cyclic, manic thiab hypomanic tej yam kev mob yuav tshwm sim thaum kho nrog amitriptyline. Hauv qhov no, txo qhov koob tshuaj lossis tso tseg cov tshuaj.
Hauv cov neeg mob uas muaj thyrotoxicosis, ntxiv rau cov neeg uas tau txais cov thyroid hormones, cov teebmeem cardiotoxic yuav tshwm sim.
Ua ke nrog kev kho mob electroconvulsive, cov tshuaj tsuas yog siv nyob rau hauv kev saib xyuas kev kho mob.
Cov neeg mob ua raws li lub txaj so tej zaum yuav muaj qhov txhaws txhaws txhaws tsis taus.
Yog tias muaj tshuaj loog hauv zos lossis dav dav, koj yuav tsum qhia koj tus kws kho mob txog kev noj tshuaj amitriptyline.
Tej zaum ib qho kev txo qis hauv lacrimation thiab kev nce ntawm cov hnoos qeev hauv cov kua muag ua kua. Txog cov tsom iav lo ntsiab muag, qhov no tuaj yeem cuam tshuam rau corneal epithelium.
Cov tib neeg noj amitriptyline rau lub sijhawm ntev muaj kev pheej hmoo ntawm caries.
Kev saib xyuas yuav tsum tau saib xyuas thaum ua cov haujlwm phom sij uas yuav tsum tau saib xyuas thiab ceev nrawm. Thaum tsav tsheb, kev siv amitriptyline tsis pom zoo.

Raws li kev tshwm sim tshwm sim, cov qeb ntawm tib neeg no yuav tsum siv cov tshuaj no nrog kev ceev faj:

quav cawv quav cawv
cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 14 xyoos,
cov neeg laus laus
nyob rau hauv cov kab mob xws li mob schizophrenia, mob ntsws asthma, muaj kev puas siab ntsws bipolar, mob puas ntsoog, mob inhibition ntawm cov pob txha txha ntshav txhaws, mob plawv thiab mob voos, mob ntshav siab, mob ntshav nce hlwb, qis lub cev muaj zog ntawm lub plab thiab cov hnyuv, lub siab, lub raum tsis ua haujlwm, thyrotoxicosis, mob qog ntshav, ncua sijhawm zais zis hypotension.

Amitriptyline dependence

Cov tshuaj tsis yog rau cov tshuaj yeeb yaj kiab, vim nws tsis muaj qhov ua rau qaug tshuaj lossis qaug tshuaj, tsis ua rau lub zog ua kom lub cev muaj zog, zoo li opiates. Kev tso siab rau amitriptyline tsuas yog kev puas siab ntsws, uas tsis muaj dab tsi ua rau lub cev nqaij daim tawv rau cov tshuaj. Txhawm rau kom nkag siab txog kev quav yeeb tshuaj, koj yuav tsum paub lub hauv paus ntsiab lus ntawm kev siv yeeb tshuaj - lub cev ua kom lub cev tsis ua rau lub cev puas sib luag li qub, yog li lawv tsis pauv mus ntev. Cov txiaj ntsig ntawm kev noj cov tshuaj amitriptyline yog ua tiav los ntawm kev saib xyuas cov teeb meem ntawm serotonin thiab lwm cov neurotransmitters ntawm qib siab.

Puas yog amitriptyline muaj yees? Zoo li txhua yam tshuaj tiv thaiv kev ntxhov siab, nws muaj peev xwm los tsim ib qho kev vam khom - nrog kev tshem tawm sai, cov tsos mob rov tshwm dua. Tsuas yog nyob rau hauv qhov kev txiav txim siab no tuaj yeem amitriptyline raug suav hais tias yog ib qho yeeb tshuaj, txij li thaum lub sijhawm siv tshuaj, tus neeg zoo, thiab thaum ua tiav qhov kev mob, tus mob rov qab los. Nws thiaj li tshwm sim uas cov neeg mob hloov ntawm cov tshuaj tiv thaiv kev txom nyem mus rau kev siv tshuaj tiag. Yog li, thiaj li yuav tshem tawm qhov kev phom sij uas yuav tshwm sim los ntawm amitriptyline, nws qhov kev txais tos raug muab tso tseg maj, nyob hauv ib hlis.

Ntsoos ntsoos mob

Nrog kev tsis lees paub meej ntawm cov tshuaj, tshwj xeeb tshaj yog tias nws tau noj ntau dua, nws yog qhov ua tau ntawm kev txhim kho ntawm amitriptyline ntsoos ntsoos mob. Cov tsos mob zoo li cas?

xeev siab
ntuav
mob taub hau
zawv plab
pw tsaug zog
malaise
npau suav phem.

Txawm hais tias muaj qhov ua tsis tiav, lub cev muaj zog ntxhov siab, kev npau taws, pw tsaug zog, npau suav hnyav tsim.

Lub sijhawm tshem tawm amitriptyline ntev npaum li cas? - tus mob yog pom thaum lub sijhawm, kom txog rau thaum tag nrho cov tshuaj tawm, uas yog, 8-14 hnub. Cov kev qhia txuas ntxiv yog twb muaj kev xav ntau dua nyob hauv cov xwm.

Cov txheej txheem rau txo amitriptyline kev nkag mus yog txo qis hauv kev kho mob ntau dua hauv lub hlis pib txij li ¼ thiab txog thaum nws muab tso tseg.

Ua rau ntawm overdose

Dhau ntawm kev noj tshuaj rau ib lub koob ntawm cov tshuaj feem ntau tshwm sim hauv cov xwm txheej hauv qab no:

tsis ua raws li cov koob tshuaj uas tus kws kho mob tau sau cia (txhob txwm lossis xwm txheej dhau hwv),
ywj siab kev siv tshuaj yam tsis muaj kws kho mob sau,
kev sib xyaw ntawm cov tshuaj hauv cov tshuaj kho zoo nrog dej cawv.

Tshuav cov tsos mob

Ua raws li tus nqi ntawm amitriptyline coj, 3 qib ntawm kev haus dej haus ntau dhau los yog qhov txawv - mob me, mob hnyav thiab mob hnyav, uas tsis muaj kev ntsuas rov mob rau qhov kawg ua rau muaj 100% ntawm cov mob.

Cov menyuam yaus feem ntau cuam tshuam txog kev noj ntau dhau, txawm tias ua rau neeg tuag taus.

Kev haus me ntsis ntawm amitriptyline yog qhia los ntawm cov tsos mob hauv qab no:

qhov ncauj qhuav
cem quav
tsis muaj zis
dyspepsia.

Cov cim ntawm kev siv ntau tshaj ntawm cov neeg kawm ntawv siab thiab mob hnyav ib txwm mob hnyav thiab xav tau kev kho mob sai sai.

Los ntawm ib sab ntawm lub hauv nruab nrab cov hlab hlwb - nce tsaug zog, tso zis, tsis muaj kev ntxhov siab, mob qaug dab peg, nce tsis meej, hais lus tsis meej, leeg tsis meej pem, tsis meej pem, poob ntawm kev taw qhia hauv qhov chaw, txo qis, kev xav ntxhov siab, ataxia, hnov qab, tsis nco qab.
Los ntawm ob sab ntawm lub plawv thiab cov hlab ntshav - arrhythmia, tachycardia, ua txhaum ntawm intracardiac conduction, lub plawv tsis ua haujlwm, poob qis hauv cov ntshav siab, poob siab, mob plawv (feem ntau).
Lwm qhov kev pom tshwm sim yog txo qis ntawm cov zis, ntxiv rau nws qhov kev qhaj tsis tiav, hyperthermia, nce tawm hws, ntuav, ua tsis taus pa, ua pa nyuaj, cyanosis, raum thiab mob siab ua haujlwm.
Ntawm cov theem davhlau ya nyob twg, ntshav siab poob qis, cov menyuam kawm tsis teb rau lub teeb, reflexes fade, hepatic, plawv nres, thiab ua pa ntes.

Cov koob tshuaj ua kom tuag yog 1.5 grams ntawm amitriptyline noj ib zaug. Txawm li cas los xij, tsawg dua yog qhov tsis txaus rau menyuam yaus.

Lom tshuaj kho

Ntawm thawj cov cim ntawm kev siv ntau tshaj, nws yog ib qho tsim nyog yuav tsum tau ua cov haujlwm ua ntej ntsuas mob.

Hu rau lub tsheb tos neeg mob.
Muab rau tus neeg mob haus ib liv dej thiab ua rau ntuav. Rov ua qhov txheej txheem no kom txog thaum ntxuav huv dej tuaj.
Siv cov enterosorbents los txo cov tshuaj uas nqus mus rau hauv cov ntshav - Enterosgel, cov pa roj carbon activated, Atoxil, Polysorb MP thiab lwm tus.
Yog tias tus neeg poob siab, nws yuav tsum tig mus rau ib sab.

Kev kho mob ntawm amitriptyline lom yog nqa tawm hauv kev saib xyuas mob siab thiab suav nrog kev ntsuas tshuaj hauv qab no.

Lub plab zom mov ceev.
Kev qhia ntawm ntsev daws los tswj cov ntshav siab, txhim kho acidosis, dej-electrolyte tshuav nyiaj li cas.
Noj cov tshuaj cholinesterase inhibitors kom tshem tawm cov kab mob anticholinergic.
Cov lus qhia ntawm glucocorticoids nrog txoj kev poob qis hauv cov ntshav siab.
Qhia tshuaj tiv thaiv tshuaj rau lub plawv.
24-teev cov neeg mob soj ntsuam nrog saib xyuas cov ntshav siab thiab lub plawv dhia.
Hauv qhov xwm txheej loj - rov ua kom rov mob dua, ntsuas qhov ua tau zoo, hloov ntshav ntxiv.

Hemodialysis thiab kev yuam diuresis tsis tau pom tias muaj txiaj ntsig zoo ntawm kev noj tshuaj tshaj nrog amitriptyline.

Tsis muaj ib qho tshuaj tshwj xeeb rau cov tshuaj amitriptyline lom.

Qhov muaj teeb meem ntawm kev lom

Ib qho kev haus ntau dhau yog tuag taus, txawm hais tias kev kho mob tau tuaj raws sijhawm. Cov ua kom muaj kev tuag yog plhaw nres, ua pa, mob plawv tas li.

Qhov tshwm sim ntawm kev haus luam yeeb ntawm amitriptyline tseem nyob, txawm tias ib tug neeg tswj kom ciaj sia:

hloov kev xav, kev nyuaj siab loj,
mob raum thiab mob hepatic,
lub siab ua ntxhov.

Cov teebmeem tshwm sim tau sau tseg thoob plaws lub neej thiab xav tau kev kho mob tsis tu ncua.

Cov txheej txheem sib piv ntawm amitriptyline yog cov tshuaj yeeb teb chaw Saroten Retard, uas yog tsim los ntawm H. LUNDBECK A / S (Denmark).

Dab tsi ntxiv tuaj yeem hloov amitriptyline? Cov pab pawg analogues yog Anafranil, Doxepin, Melipramin, Novo-Tryptin - cov tshuaj muaj cov nyhuv tib yam, tab sis txawv ntawm muaj pes tsawg leeg. Cov tshuaj no yog cov duab niaj hnub ntawm amitriptyline yam tsis muaj kev phiv cov yam ntxwv ntawm kev noj tshuaj tiv thaiv kab mob.

Kev cuam tshuam nrog lwm yam tshuaj

Ua ntej koj pib kho nrog amitriptyline, koj yuav tsum qhia koj tus kws kho mob txog txhua yam tshuaj uas noj txuas ntxiv.

Nws tsis tuaj yeem ua ke nrog MAO inhibitors.
Amitriptyline pab txhim kho txoj kev ua kom lub hlwb hloov zuj zus, txo lub cev tsis ua haujlwm, ua kom loog, tshuaj rau tshuaj loog, tshuaj tiv thaiv kab mob thiab tshuaj uas muaj ethanol.
Txo cov txiaj ntsig ntawm anticonvulsants.
Nws tuaj yeem raug sau ua ke nrog kev noj tshuaj tsaug zog (piv txwv li "Sonapax" tau noj nrog amitriptyline). Tab sis nyob rau hauv kev sib xyaw ua ke no, nws nce qhov kev ua haujlwm anticholinergic ntawm Sonapax - uas yog, nws txo lub peev xwm ntawm lub hlwb hlwb kom xa cov paib.
Ua ke nrog lwm cov tshuaj tiv thaiv kev ntxhov siab, cov teebmeem ntawm ob qho tshuaj tau txhim kho.
Thaum ua ke nrog cov tshuaj tiv thaiv kev tiv thaiv thiab cov tshuaj tiv thaiv anticholinergic, qhov kub ntawm lub cev tuaj yeem nce ntxiv thiab ua kom tuag tes tuag taw txoj hnyuv txuas tuaj.
Amitriptyline txhim kho kev mob ntshav siab ntawm catecholamines thiab adrenostimulants, nce ntawm kev pheej hmoo ntawm tachycardia, mob plawv dhia tsis ua hauj lwm, thiab mob ntshav txhaws ntshav siab.
Yuav txo qis cov nyhuv antihypertensive ntawm guanethidine thiab tshuaj zoo sib xws.
Hauv kev sib xyaw nrog kev sib raug zoo ntawm coumarin lossis indandion, anticoagulant cov haujlwm ntawm tom kawg yuav nce ntxiv.
Ua ke nrog cov cimetidine, amitriptyline concentration hauv cov ntshav plasma nce ntxiv, uas ua rau muaj kev cuam tshuam ntau dua ntawm cov tshuaj lom.
Inducers ntawm microsomal daim siab enzymes (carbamazepine thiab lwm cov barbiturates) txo qhov kev xav ntawm amitriptyline.
Quinidine txo qis amitriptyline metabolism.
Cov tshuaj hormones estrogen nce cov bioavailability ntawm amitriptyline.
Hauv kev sib xyaw nrog disulfiram thiab acetaldehyde dehydrogenase inhibitors, delirium tuaj yeem txhim kho.
Amitriptyline muaj peev xwm txhim kho kev nyuaj siab, uas tshwm ntawm cov keeb kwm ntawm glucocorticoids.
Ua ke nrog cov tshuaj rau kev kho mob thyrotoxicosis, kev pheej hmoo ntawm kev tsim txom agranulocytosis nce ntxiv.
Kev sib xyaw nrog nootropics ua rau qaug zog ntawm qhov kev txiav txim ntawm cov tshuaj no thiab ua rau kom muaj kev cuam tshuam ntawm kev phiv.
Kev ceev faj yuav tsum tau ua ke nrog digitalis thiab baclofen.
Zoo sib xyaw ntawm amitriptyline nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob (piv txwv li, Acyclovir). Nws tuaj yeem ua ke raws li tus kws kho mob tau qhia.

Cov Lus Nquag Nug

Peb yuav teb cov lus nug nrov tau muab tso ua ke ntawm cov lus nug tshawb fawb cuam tshuam txog cov yam ntxwv ntawm kev siv amitriptyline thiab nws cov tshuaj sib xyaws nrog lwm cov tshuaj tsis tau teev nyob rau hauv cov lus qhia ntawm nom tswv.

Puas yog amitriptyline tshuaj lossis tsis sau? Cov lus pom zoo muag hauv cov chaw muag tshuaj - tsuas yog daim ntawv sau tshuaj.
Dab tsi yog sib haum ntawm amitriptyline thiab donormil, cov tshuaj no tau tuaj yeem ua ke? Qhov kev sib xyaw ua ke no yog ua los ntawm cov kws kho mob - amitriptyline yuav txhim kho cov nyhuv ntawm Donormil. Tab sis kev noj tshuaj yog coj nyob rau txawv sijhawm ntawm hnub thiab nruj me ntsis hauv tsev kho mob raws li kev saib xyuas ntawm kws kho mob.
Dab tsi yog qhov sib xyaw ntawm amitriptyline thiab phenibut? Txij li thaum "Phenibut" yog hais txog cov tshuaj nootropics, ua ke nrog amitriptyline, cov kev kho mob ntawm ob yam tshuaj txo, thiab qhov ntxim nyiam ntawm cov kev mob tshwm sim ntxiv. Qhov kev sib xyaw ua ke no yuav tsum tham nrog koj tus kws kho mob.
Puas yog amitriptyline siv tau nrog corvalol? Cov tshuaj tsis tuaj yeem tawm tsam, tab sis Corvalol muaj phenobarbital, uas tuaj yeem txhim kho cov nyhuv ntawm amitriptyline.
Puas yog carbamazepine (Zeptol, Carbalepsin Retard, Tegretol, Finlepsin) puas siv tau nrog amitriptyline? Cov tshuaj muaj peev xwm muab sau ua ke, tab sis nws yuav tsum nco ntsoov tias, tej zaum, qhov nce ntxiv ntawm cov nyhuv inhibitory rau hauv lub hauv nruab nrab cov hlab ntsha, ib qho kev txo qis ntawm cov nyhuv anticonvulsant ntawm carbamazepine thiab txo qis ntawm cov tshuaj amitriptyline hauv cov ntshav.
Tau amitriptyline noj nrog phenazepam? Cov tshuaj no tuaj yeem kho nyob rau hauv cov kab sib tw nkaus xwb hauv cov chav kawm luv, txhawm rau kom sai sai ntawm cov tsos mob thiab txo cov kev mob tshwm sim ntawm cov tshuaj tiv thaiv kab mob.
Puas yog amitriptyline thiab cinnarizine tau tshaj? Kev muab tshuaj yog ua tau, tab sis nyob rau hauv kev saib xyuas ntawm tus kws kho mob, txij li nyob rau hauv kev sib xyaw no cov nyhuv ntawm cov tshuaj tiv thaiv yuav muaj zog dua.
Dab tsi yog ntawm fluoxetine thiab amitriptyline, lawv tuaj yeem ua ke? Cov tshuaj fluoxetine kuj tseem yog cov tshuaj tiv thaiv kab mob, tab sis los ntawm lwm pab pawg sib txawv thiab nrog qhov kev coj ua zoo tshaj plaws. Kev sib xyaw ua ke yog ua tau siv kev siv tshuaj tsawg kawg nkaus thiab tsuas yog raws li kws kho mob tau hais, tab sis nws yog qhov txaus ntshai rau kev txhim kho kev phiv.
Puas yog Velafax sib raug nrog amitriptyline? Nws tseem yog cov tshuaj tiv thaiv kev nyuaj siab, qhov kev coj ua ntawm kev ua kom sib txawv. Lawv txoj kev sib xyaw ua ke yog ua tau, tab sis cov tshuaj tau muab faib rau lub sijhawm - "Velafax" thaum sawv ntxov, thiab amitriptyline thaum yav tsaus ntuj nyob rau hauv qis dua thiab lawv yuav tsum saib xyuas lub cev cov tshuaj tiv thaiv txhawm rau tshem tawm cov nyhuv inhibitory rau hauv nruab nrab lub paj hlwb.
Puas yog amitriptyline sib haum nrog piracetam? Nootropics tsis pom zoo kom ua ke nrog cov tshuaj tiv thaiv kab mob vim tias qhov sib txawv hauv lawv cov kev nqis tes ua - txhawb kev tawm tsam. Qhov ua tau zoo ntawm ob lub tshuaj yuav txo qis thiab qhov kev pheej hmoo ntawm cov kev mob tshwm sim tuaj yeem nce ntxiv. Yog tias qhov sib xyaw ua ke no yog kws kho mob sau tseg los ntawm tus kws kho mob, ces nws raug nquahu kom faib cov kev nqus ntawm cov ntsiav tshuaj raws sijhawm.
Kuv puas tuaj yeem haus cov amitriptyline thiab Paxil tib lub sijhawm? Cov no yog ob yam tshuaj tiv thaiv kev txom nyem los ntawm ntau pab pawg sib txawv. Xws li kev sib xyaw yog siv, tab sis tsis tuaj yeem coj ntawm nws tus kheej, vim tias muaj kev pheej hmoo ntawm kev ua kom zoo ntxiv ntawm ob qho ntawm lawv.
Dab tsi yog qhov sib xyaw ntawm amitriptyline thiab Eglonil? Qhov no yog cov tshuaj tiv thaiv kev mob hlwb nrog cov tshuaj tiv thaiv kev tiv thaiv, yog li thaum siv ua ke, muaj kev pheej hmoo los txhim kho qhov cuam tshuam rau lub hauv nruab nrab lub paj hlwb. Yog hais tias xws li kev sib xyaw ua ke yog xyaum, tom qab ntawd cov tshuaj raug kho nyob rau lwm lub sijhawm.
Kuv puas tuaj yeem nqa nrog escitalopram nrog amitriptyline? Kev sib xyaw ntawm ob yam tshuaj tiv thaiv tsis zoo ib txwm tsis tsim nyog. Qee zaum qhov kev sib xyaw ua ke no tau ua hauv kev nyuaj siab, tab sis cov txiaj ntsig kho tau zoo tshaj plaws nrog kev sib txuam ntawm cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob.
Kuv puas tuaj yeem noj Afobazole thiab amitriptyline ua ke? Cov tshuaj muaj kev sib haum xeeb txij li Afobazol hais txog kev tawm suab thiab feem ntau yog muab coj los ua ke nrog cov tshuaj tiv thaiv kev ntxhov siab. Tab sis tawm tsam keeb kwm ntawm amitriptyline muaj zog, cov nyhuv ntawm Afobazole yuav ploj, yog li, tsuas yog tus kws kho mob yuav tsum xaiv cov tshuaj siv kho mob.
Tau Amitriptyline thiab Atarax tau noj ua ke? Cov tshuaj no yog cov tshuaj los ntawm cov pab pawg tawm tsam, yog li nws muaj feem yuav ua ke nrog amitriptyline hauv kev nyuaj siab hauv lub xeev. Tab sis lawv txais tos ntawm txawv sijhawm yuav tsum tau ua.
Puas muaj cov tshuaj uas tuaj yeem yuav tom lub txee nrog amitriptyline? Muaj lub teeb uas tsis yog daim ntawv yuav tshuaj, qhov ua tau los ntawm kev tuaj yeem raug tshuaj los tiv thaiv tshuaj - Persen, Novo-Passit, Deprim, Azafen thiab lwm tus. Tab sis muag tshuaj tsis tau daim ntawv qhia tsis tau txhais tau tias koj tuaj yeem sau ntawv kho koj tus kheej!
Yuav amitriptyline thiab Finlepsin tau noj ua ke? Cov tshuaj yog siv los kho kev mob vwm, nrog rau neuralgia thiab mob, yog li nws muaj peev xwm nce cov nyhuv inhibitory nyob rau hauv nruab nrab cov hlab ntsha ntawm amitriptyline lossis txo nws cov tshuaj nyob hauv cov ntshav.
Puas yuav amitriptyline tau noj tshuaj tsaug zog? Thaum insomnia tsis txuam nrog kev nyuaj siab, cov tshuaj tsis qhia.
Yog hais tias amitriptyline feem ntau noj, cov tshwm sim zoo li cas? Kev kho mus sij hawm ntev tas li ib txwm ua nrog qhov kev pheej hmoo siab ntawm kev phiv. Kev kho mob nrog xws li ib qho yeeb tshuaj hnyav yuav tsum tau nqa tawm tsuas yog nyob ntawm kev saib xyuas ntawm tus kws kho mob thiab hauv kev siv tshuaj txaus.
Amitriptyline puas tuaj yeem raug muab rau tus neeg qaug cawv? Tsis yog, nws yog qhov sib txuam nrog cawv!
Puas yog amitriptyline muaj qhov kev xav ntxiv lossis tsis yog? Yog lawm, kev kho mob ntawm cov tshuaj no yog nriav thiab tshwm sim tag nrho tom qab 2-3 lub lis piam.
Vim li cas lawv tau txais rog los ntawm amitriptyline? Ib qho ntawm nws cov kev mob tshwm sim yog nce tsis qab los noj mov. Qee lub sij hawm qhov no ua rau koj qhov hnyav nce.
Puas yog amitriptyline nce lossis txo cov ntshav siab? Cov tshuaj muaj peev xwm txo tau thiab nce ntxiv. Kev dhia dhia hauv qhov ntsuas tuaj yeem pom txhua hnub.
Yuav ua li cas kom tshem tawm txoj kev qaug zog tom qab siv tshuaj amitriptyline? Kev quav rau cov tshuaj no yuav kav li 7-14 hnub. Yog tias cov xwm txheej tsis zoo, koj yuav tsum rov tshuaj dua lossis hloov cov tshuaj nrog lwm tus.
Amitriptyline ua haujlwm ntev npaum li cas? Cov tshuaj tseem ceeb nkag rau hauv cov ntshav hauv 30 feeb tom qab noj thiab nyob ntawd rau kwv yees li 7-10 teev (siab kawg 28 teev). Kwv yees li ntau li ntau ib qho kev lees txais ntawm cov tshuaj.
Tom qab lub sijhawm dab tsi yog amitriptyline raug tawm ntawm lub cev? Nws txoj kev tshem tawm tiav tshwm sim 7-14 hnub tom qab xaus ntawm kev txais tos.
Cov kws kho mob twg sau ntawv rau amitriptyline? - cov kws kho hlwb.
Yuav ntev npaum li cas Kuv tuaj yeem noj amitriptyline yam tsis muaj kev so? Lub sij hawm ntawm kev kho mob yog qhov siab tshaj plaws ntawm 8 lub hlis.

Amitriptyline - cov yeeb tshuaj muaj zog uas cuam tshuam nrog cov tshuaj tiv thaiv kev ntxhov siab ntawm cov "qub". Nws qhov kev mob tshwm sim qee zaum tshaj li qhov txiaj ntsig ntawm kev kho. Yog li, kev txiav txim siab coj nws yuav tsum tsuas yog ua los ntawm tus kws kho mob. Kev muab tshuaj rau nws tus kheej siv tshuaj yog kev phom sij txog lub neej!

Muaj pes tsawg leeg thiab lub zog

Cov tshuaj no tau pom zoo hauv kev kho mob zoo li tshuaj tua kab mob zooCov. Nws zwm rau txoj kev txhais hais tias ntawm lub caij tricyclic, thiab tseem muaj cov yeeb yam nram no:

raws li tus neeg sawv cev analgesic ntawm hauv paus pib,
raws li txhais tau tias txo qis qab los noj mov thiab tshem tawm cov mob tsis ua kom tso zis, tus neeg sawv cev nrog antiserotonin cov yam ntxwv,
pom zoo siv rau hauv bulimia nervosa.

Muaj cov qauv hauv cov ntsiav tshuaj lossis tshuaj daws. Feem ntau cov feem ntau, daim ntawv ntsiav tshuaj siv hauv kev kho mob. Xim tuaj yeem yog dawb lossis daj. Daim ntawv tso tawm - tiaj tus kheej kheej.

Muaj ib qho chamfer hauv cov ntsiav tshuaj, uas ua kom cov khoom noj tshuaj kom raug raws li kws kho mob tau sau tseg thaum amitriptyline. Cov lus qhia ntxaws ntxaws rau kev siv amitriptyline hauv cov ntsiav tshuaj yog qhov yuav tsum tau ntim rau hauv lub thawv ntawv thawv.

Qhov no nthuav! Vim li cas cov tshuaj diazepam tau sau tseg: cov lus qhia rau kev siv (antide)

Thaum muab tshuaj, tus kws kho mob yuav qhia koj txhua yam txog amitriptyline: dab tsi pab, yuav ua li cas coj nws kom raug.

Ib qhov tshwj xeeb yog qhov ua tau zoo peripheral thiab central anticholinergic kev txiav txim siab, muaj zog sedation.

Thaum noj, muaj qhov nce ntxiv ntawm qhov kev txiav txim ntawm serotonin thiab norepinephrine nyob hauv nruab nrab lub paj hlwb, nrog rau cov txheej txheem ntawm kev txo lawv cov theem ntawm rov qab nqus.

Thaum siv

Lub hauv paus yog vim li cas rau qhov kev teem caij yog suav hais tias yog kuaj tau muaj kev nyuaj siab, uas yog nrog:

kev ntxhov siab vim pw tsaug zog
insomnia
nce kev ntxhov siab,
ntxhov siab
lwm qhov kev tshwm sim ntawm kev nyuaj siab, nrog rau cov neeg mob thaum yau.

Nws yog tshuaj rau cov kab mob nram qab no:

nyob rau hauv cov xwm txheej ntawm kev kuaj mob schizophrenia,
hauv kev txiav txim kev tshem tawm cov tsos mob,
thaum tsis muaj qhov nqaij ntuag ntshav nrog (nocturnal enuresis), tabsis tsis muaj qhov zais zis yog zais ntshav,
nyob rau hauv cov mob ntawm mob mob ntev, suav nrog cov mob los ntawm kev kuaj mob cancer,
thaum atypical ntsej muag pleev tau raug pom,
nrog kev mob caj dab tom qab thiab lwm yam xwm txheej.

Antidepressant amitriptyline yuav raug sau tseg nrog mob taub hau heev thiab pom zoo rau cov neeg mob lub plab mob.

Ecov nyhuv ntawm kev tiv thaiv kev poob siab lub xeev yog manifested tom qab thov rau tsawg kawg peb lub lis piam.

Kev tshuaj txiav txim

Kev lag luam kws tshuaj muaj ob hom kev tso tawm: daws thiab ntsiav tshuaj. Feem ntau, ib ntsiav tshuaj tawm tom qab noj mov.

Qhov no nthuav! Yuav ua li cas thiab los ntawm dab tsi los noj Asafen: kev taw qhia rau kev siv

Lawv tuaj yeem ua rau lub plab ntawm phab ntsa, vim li no nws tsis pom zoo kom muab zom. Thaum noj nrog dej.

Hauv thawj theem ntawm kev kho, qhov tshuaj ntau npaum 25-50 mg yog siv. Cov koob tshuaj tau pom zoo kom noj thaum hmo ntuj. Raws li koj tau txais hauv tsib hnub ntau dua qhov ntxiv tshwm sim txog 200 mg rau ib hnub.

Tus nqi no raug faib ua peb zaug tom qab noj tshais, noj su thiab noj hmo. Yog tias tsis muaj cov txiaj ntsig zoo tom qab 2 lub lis piam ntawm kev tswj hwm, qhov tshuaj yuav raug nce ntxiv rau 300 mg.

Thaum xaiv txoj kev daws teeb meem, nws yog muab cov tshuaj intramuscularly ntawm 20-40 mg rau ib zaug txhaj. Kev hno tau ua 4 zaug nyob rau ib hnub, maj mam hloov tus neeg mob mus rau kev siv cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj.

Yog tias cov tshuaj siv rau hauv kev kho mob, mob taub hau, ntau dua koob tshuaj yog 100 mg ib hnub.

Hom mob tshwm sim

Cov tshuaj no muaj ntau cov kev mob tshwm sim.

Rau amitriptyline, daim ntawv tso tawm nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj los yog kev daws teeb meem yog qhov tsim nyog los ntawm cov lus qhia ntxaws uas muaj cov kev cuam tshuam zoo li no hauv kev nthuav dav.

Xws li thaum noj tuaj yeem pom:

Cov kev xav tsis zoo ntawm cov leeg poob siab, suav nrog muaj zog arousal, qhov tshwm sim ntawm tsaus muag ntawm cov neeg mob thiab cov kev xav hauv nruab siab, cov yam ntxwv ntawm lub cev muaj zog ntxhov siab, ua rau muaj kev cuam tshuam ntawm cov tsos mob depressive thiab lwm tus.
Nyob rau ib feem ntawm cov hlab plawv, cov kev mob tshwm sim yog cim los ntawm arrhythmia, qhov zoo li cuam tshuam nyob rau hauv kev kuaj mob intraventricular, tachycardia, thiab ib qho kev nce ntawm cov zaus ntawm cov hlab plawv txhaws.
Cov plab zom mov tau sau tseg, suav nrog tsaus nti ntawm tus nplaig, kab mob siab, cov tsos ntawm cov kev hloov pauv hauv sajcov kev ntuav thiab raws plab.
Anticholinergic cov teebmeem yuav tshwm sim hauv daim ntawv ntawm kev pom kev plooj plooj, qhov nce siab hauv kev mob siab ntawm intraocular, tachycardia, delirium. Tsis meej pem ntawm kev nco qab yog sau tseg thiab theem ntawm kev tawm hws tsawg.

Cov kev tshwm sim tsis zoo raug sau tseg tom qab kawm tiav chav kawm lossis tshem tawm.Xws li kev npau suav txawv txawv, txhaws plab thiab xeev siab, pw tsis tsaug zog thiab mob taub hau tas li.

Yog tias muaj qhov tshwm sim tsis txaus ntseeg, koj yuav tsum tau sab laj nrog kws kho mob tam sim ntawd los kho qhov kev kho mob, vim tias rau ib qho tshuaj xws li amitriptyline, cov kev mob tshwm sim yuav muaj kev phom sij rau tus neeg mob lub xeev kev noj qab haus huv.

Qhov no nthuav! Vim li cas adaptol pab: cov lus qhia rau siv

Txawm tias thaum qhov ntsuas pom zoo rau kev siv rau amitriptyline yog lub hom phiaj, nws yog qhov tsim nyog kev tshuaj xyuas tas mus li ntawm tus neeg mob lub noj qab haus huvCov. Qhov tseem ceeb xws li contraindications thiab muaj kev phiv tshuaj ntau yuav tsum tau coj mus rau hauv qhov kev txhim kho ntawm chav kawm ntawm kev kho mob thiab kev xaiv tshuaj.

Yog tias tau ua txhaum thaum lub caij noj mov thiab kev haus dej ntau dhau tshwm sim, nws yuav ua rau pom nws tus kheej tias qhov tsis zoo ntawm qhov chaw ntawm tag nrho cov kab ke cev. Xws li cov hlab ntsha hauv nruab nrab, hlab plawv, mob plab hnyuv. Los ntawm cov kev ua kom pom, lawv zoo sib xws rau qhov phiv ntawm kev pub nkag.

Kev noj tshuaj ntau dhau yog sau tseg thaum siv tshuaj hauv ntsiav tshuaj thiab daws. Yog tias qhov koob tshuaj ntau dua thaum siv cov tshuaj tswj hwm qhov ncauj, yuav ua rau mob plab zom mov sai. Nws yog ib qho tseem ceeb kom hu lub tsheb thauj neeg mob tam sim ntawd. Ua ntej cov kws kho mob tuaj txog, kev tso dej tawm yog ua tiav lawv tus kheej los ntawm tus neeg mob thiab nws tsev neeg. Xws li cov kev ua haujlwm tawm yog qhov yuav tsum tau ua vim tias daim ntawv teev kev phom sij ntawm cov kev qhia tsis zoo, uas qee qhov tuaj yeem xaus nrog lub plawv nres.

Analogues ntawm cov tshuaj

Cov cuab yeej no muaj ntau yam analogues. Hauv tag nrho, muaj plaub caug hom tshuaj xaiv tau tuaj yeem muab tau.

Nrog rau cov tshuaj: gelarium hypericum, lotonica, dystonicum, azafen, neurol, valdoxane, citron, gerfonal.

Qhov kev xaiv ntawm cov tshuaj analogue yog nqa los ntawm kws tshwj xeeb. Yus tus kheej tshem tawm lossis hloov pauv tsis pom zoo.

Cov tshuaj zoo sib xws no pab ua rau muaj kev ntxhov siab loj thiab lub cev tsis haum. Rau amitriptyline, cov analogues muaj ntau thiab pub koj xaiv cov kev kho kom zoo. Cov tshuaj zoo sib xws rau kev nqis tes ua rau amitriptyline pab muab kev pab rau txhua tus neeg mob uas thov.

Cov Lus Siv tshwj xeeb

Yog tias siv txoj kev daws teeb meem tau hais tseg, kev qhia yog nqa tawm hauv tsev kho mob nkaus xwb thiab nrog kev saib xyuas tas li ntawm cov kws kho mob. Hauv thawj hnub ntawm kev nkag mus hauv ib qho twg, tus neeg mob yuav tsum ua tib zoo soj ntsuam kom lub txaj pw.
Ua ntej yuav noj, ntshav siab yog tswj cov ntshav.
Los ntawm ethanol tag nrho lub sijhawm ntawm kev tswj hwm yuav tsum tau tso tseg kom meej, xws li kev sib xyaw yog qhov txaus ntshai rau tus neeg mob lub neej.
Tiav kev siv ntawm cov tshuaj nyob rau hauv kev kho mob yog yuav tsum tau maj mam, kev muab txo qis txhua hnub nojCov. Nrog rau qhov kev txiav tawm ntawm kev siv rau hauv ntau feem pua ntawm cov neeg mob, ib qho qhia tias "tshem tawm txoj kev mob" yog pom, uas tuaj yeem ua rau muaj kev tawm tsam tshiab thiab tsis zoo los tiv thaiv.
Thaum noj, tswj lub peev xwm ntawm kev txhim kho manic xeev, uas feem ntau tuaj yeem pom nrog cyclic thiab cuam tshuam los ntawm kev nyuaj siab yog qhov xav tau.