Ofloxin 200 (Ofloxin® 200)

Kev piav qhia cuam tshuam rau 21.04.2016

• Lub npe Latin: Ofloxacin
• ATX Code: J01MA01
• Yam tshuaj muaj sia: Ofloxacin (Ofloxacin)
• Chaw tsim tshuaj paus: Pharmstandard-Leksredstva, Synthesis Kurgan Kev Sib Koom Tes ntawm Cov Tshuaj thiab Cov Khoom lag luam OJSC, Valenta Pharmaceuticals, Skopinsky Pharmaceutical Plant, MAKIZ-PHARMA, Obolenskoye - chaw tsim tshuaj lag luam, Rafarma ZAO, Ozon LLC, Krasfarma, Biosynthesis OJSC (Russia)

• Hauv 1 ntsiav tshuaj - 200 thiab 400 mg ofloxacinCov. Hmoov txhuv nplej siab, MCC, talc, magnesium stearate, polyvinylpyrrolidoneAerosil li cov ntu pabcuam.
• Hauv 100 ml kev daws - 200 mg ntawm cov tshuaj nquag. Sodium chloride thiab dej, raws li cov pabcuam pabcuam hauv qab.
• Hauv 1 g tshuaj pleev - 0.3 g ntawm cov tshuaj nquag. Nipagin, roj av jelly, nipazole, raws li cov ntu pabcuam.

Cov Tshuaj Hauv Tshuaj

Isloloacin puas yog tshuaj tua kab mob lossis tsis yog? Qhov no tsis yog tshuaj tua kab mob, thiab tus kabmob antibacterial los ntawm pawg fluorinated quinolonesuas tsis zoo ib yam. Cov sib txawv ntawm cov tshuaj tua kab mob hauv cov qauv thiab keeb kwm. Fluoroquinolones tsis muaj cov kab sib txig sib xyaw, thiab cov tshuaj tua kab mob yog cov khoom ntawm lub hauv paus chiv keeb.

Cov kab mob muaj txiaj ntsig yog cuam tshuam nrog kev txwv tsis pub muaj DNA gyrase, uas nkag mus rau kev ua txhaum ntawm DNA sib txuas thiab kev faib tawm ntawm tes, kev hloov pauv ntawm phab ntsa cell, cytoplasm thiab cell tuag. Kev suav ua ntawm fluorine atom nyob rau hauv quinoline lwg me me tau hloov pauv qhov pom ntawm cov tshuaj tiv thaiv - nws tau nthuav dav thiab tseem muaj cov kab mob me me tawm tsam cov tshuaj tua kab mob thiab cov kab mob uas tsim cov beta-lactamases.

Gram-positive thiab gram-cov kab mob tsis zoo yog rhiab rau tshuaj, thiab mob chlamydia, ureaplasmas, mycoplasmas, vaj loogCov. Txwv tsis pub muaj kev loj hlob ntawm mycobacteria tuberculosisCov. Tsis cuam tshuam dab tsi Treponema pallidumCov. Microflora tsis kam hloov maj mam. Cov ntawv tshaj tawm tom qab tua tshuaj yog cov yam ntxwv.

Cov Tshuaj Pharmacokinetics

Kev nqus tau tom qab kev tswj hwm qhov ncauj yog qhov zoo. Bioavailability 96%. Ib qho tseem ceeb ntawm cov tshuaj khi rau cov protein. Qhov siab tshaj plaws tau txiav txim siab tom qab 1 h. Nws tau faib zoo hauv cov ntaub so ntswg, kabmob thiab dej, nkag mus rau hauv lub hlwb. Cov ntsiab lus tseem ceeb tau pom nyob hauv cov qaub ncaug, hnoos qeev, mob ntsws, myocardium, plab hnyuv, cov pob txha, cov qog prostate, poj niam cov chaw mos, cov tawv nqaij thiab fiber.

Nws nkag mus tau zoo los ntawm txhua qhov kev thaiv thiab nkag mus rau hauv cov kua dej ua kua dej. Txog 5% ntawm koob tshuaj yog biotransformed hauv daim siab. Ib nrab-lub neej yog 6-7 teev. Nrog kev tswj hwm rov ua dua, kev lav ntxiv tsis hais tawm. Nws yog tawm los ntawm lub raum (80-90% ntawm qhov koob tshuaj) thiab ib qho me me nrog cov kua tsib. Nrog raum tsis ua haujlwm, T1 / 2 nce. Nrog rau daim siab ua haujlwm, kev nthuav tawm kuj tseem tuaj yeem ua rau qeeb.

Kev ntsuas rau siv

• mob ntsws, mob ntsws,
• Cov kab mob hauv ENT (pharyngitis, mob hlab ntsws, otitis media, laryngitis),
• raum thiab mob txeeb zigpyelonephritis, txoj hlab zis, cystitis),
• kis kab mob ntawm daim tawv nqaij, cov nqaij mos, pob txha,
• endometritis, salpingitis, parametritis, oophoritis, mob ncauj tsev menyuam, colpitis, prostatitis, epididymitis, mob ntsws,
• gonorrhea, mob chlamydia,
• corneal mob txhab blepharitis, pom mob pob txha, keratitis, barley, chlamydial qhov txhab ntawm qhov muag, tiv thaiv kev kis kab mob tom qab raug mob thiab kev ua haujlwm (rau tshuaj pleev).

Cov Yuav Tsum Muaj

• hnub nyoog txog 18 xyoo
• kev tiv thaiv tsis haum
• cev xeeb tub,
• pub niam mis,
• qaug dab peg lossis nce kev npaj rov qab tom qab raug mob hlwb, raug mob qog nqaij hlav ntshav thiab lwm yam kab mob ntawm cov hlab ntsha hauv nruab nrog,
• yav tas los sau tseg cov leeg nyob tom qab kev tswj hwm fluoroquinolones,
• peripheral neuropathy,
• intolerance lactose,
• hnub nyoog txog li 1 xyoo (rau tshuaj pleev).

Nrog ceev faj yog kho rau cov kab mob organic ntawm lub hlwb, myasthenia gravisua txhaum cai hnyav rau daim siab thiab lub raum, hepatic porphyria, lub plawv tsis ua hauj lwm, mob ntshav qab zib, myocardial infarctionparoxysmal ventricular tachycardia, bradycardiathaum laus.

Sab sij huam

Tej yam tshwm sim tsis zoo:

Muaj tsawg qhov tshwm sim tsis tshua muaj tshwm sim:

• kev ua si ntau dua transaminase, cholestatic mob daj ntseg,
• kab mob siab, hemorrhagic mob plab, pseudomembranous mob plab,
• mob taub hau, kiv taub hau,
• ntxhov siab, txob taus,
• insomniakev npau suav zoo heev
• ntxhov siab vim, phobias,
• kev nyuaj siab,
• tshee hnyocramps
• paresthesia ntawm nquaperipheral neuropathy,
• pom mob pob txha,
• tinnitus hnov lus tsis zoo,
• kev ua txhaum ntawm kev ua rau xim tsis pom kev, ua ob lub zeem muag
• saj mob
• leeg leeg, myalgia, arthralgiamob hauv cov nqua
• leeg caj dab
• palpitations ventricular arrhythmia, ntshav siab,
• hnoos qhuav, txog siav, bronchospasm,
• petechiae,
• leukopenia, anemia, thrombocytopenia,
• lub raum tsis ua hauj lwm zoo, mob plab pliav, kev tso zis cia,
• ua pob, khaus ntawm daim tawv nqaij, urticaria,
• plab hnyuv dysbiosis.

Noj ntau dhau

Neej Neeg kiv taub hau, pauj kev chim siab, tsaug zog, tsis meej pem, kev tsis zoo, spasms, ntuavCov. Txoj kev kho yog muaj mob plab, yuam kom diuresis thiab kho tus yam ntxwv. Nrog rau kev siv tshuaj huam mob vwm Diazepam.

Kev sib txuam

Teem sijhawm ua tau zoo tshajtshuaj tiv thaiv kab mob thiab kev npaj ua kom muaj aluminium, zinc, magnesium lossis hlau, txo kom nqus ofloxacinCov. Muaj qhov nce ntxiv hauv kev ua tau zoo ntawm qhov tsis ncaj ntawm anticoagulants thaum noj nrog cov tshuaj no. Coagulation system tswj yuav tsum tau.

Txoj kev pheej hmoo ntawm cov teebmeem neurotoxic thiab cov kev ua rau qhov muaj zog nce ntxiv nrog kev tswj hwm ntawm tib txhij ntawm NSAIDs, derivatives nitroimidazole thiab methylxanthines.

Thaum ua ntawv thov nrog Theophylline nws txoj kev txiav txim siab poob qis thiab tshem tawm ib nrab-lub neej nce.

Kev siv hypoglycemic tib lub sij hawm tuaj yeem ua rau hypo- lossis hyperglycemic tej yam kev mob.

Thaum ua ntawv thov nrog Cyclosporine muaj kev nce hauv nws cov concentration hauv cov ntshav thiab ib nrab-lub neej.

Tej zaum yuav txo tau cov ntshav siab thaum thov barbiturates thiab antihypertensive tshuaj.

Thaum ua ntawv thov nrog glucocorticosteroids muaj qhov pheej hmoo ntawm leeg leeg tawg.

Muaj peev xwm ncua sijhawm ntev ntawm QT ncua nrog kev siv tshuaj tiv thaiv tshuaj, tshuaj tiv thaiv kab mob, tricyclic antidepressants, macrolides, imidazole derivatives, tshuab hlwb hlau, terfenadine, ebastina.

Kev siv cov carbonic anhydrase inhibitors, sodium bicarbonate thiab citrates, uas alkalize cov zis, ua rau muaj kev pheej hmoo ntawm crystalluria thiab nephrotoxicity.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, hauv / hauv. Cov koob tshuaj Ofloxin 200 raug xaiv ib tus zuj zus nyob ntawm qhov chaw, qhov mob hnyav, qhov mob ntawm cov kab mob me me, nrog rau cov xwm txheej dav dav ntawm tus neeg mob thiab kev ua haujlwm ntawm lub siab thiab lub raum.

Hauv / hauv cov lus qhia pib nrog kev pom zoo ib koob ntawm 200 mg, uas tau txais kev tswj hwm dropwise, maj mam dhau 30-60 feeb. Thaum tus neeg mob lub neej zoo dua, lawv pauv mus rau txoj kev tswj hwm qhov ncauj ntawm cov tshuaj nyob rau tib lub tshuaj txhua hnub.

Hauv / hauv: qhov mob txeeb zig - 100 mg 1-2 zaug ib hnub, lub raum thiab kab mob ntawm qhov chaw mos - los ntawm 100 mg 2 zaug hauv ib hnub rau 200 mg 2 zaug hauv ib hnub, mob ntsws ua pa, nrog rau ENT kabmob, kab mob ntawm daim tawv nqaij thiab cov nqaij mos, kis kab mob ntawm cov pob txha thiab pob qij txha, kis kab mob ntawm lub plab, kab mob hauv plab, mob plab - 200 mg 2 zaug ib hnub. Yog tias tsim nyog, nce qhov koob tshuaj rau 400 mg 2 zaug ib hnub.

Txog kev tiv thaiv kev kis kab mob hauv cov neeg mob uas tshaj tawm tias qhov kev tiv thaiv tsis raug - 400-600 mg / hnub.

Yog tias tsim nyog, iv dej nrog - 200 mg hauv 5% dextrose tov. Lub sijhawm tiv thaiv ntawm Txoj kev lis ntshav yog 30 feeb. Siv cov kev npaj cov kev daws teeb meem tshiab.

Sab hauv: cov neeg laus - 200-800 mg / hnub, chav kawm ntawm kev kho mob - 7-10 hnub, ntau zaus siv - 2 zaug ib hnub. Qhov tshuaj kom txog li 400 mg / hnub tuaj yeem tsim nyob hauv 1 koob tshuaj, nyiam dua thaum sawv ntxov. Nrog kab mob gonorrhea - 400 mg ib zaug.

Hauv cov neeg mob uas lub raum lub raum tsis zoo (nrog CC 50-20 ml / min), ib koob tshuaj ib zaug yuav tsum yog 50% ntawm qhov tshuaj nruab nrab nrog cov zaus ntawm kev tswj hwm ntawm 2 zaug hauv ib hnub lossis tag nrho ib koob tshuaj noj 1 zaug hauv ib hnub. Nrog CC tsawg dua 20 ml / min, ib koob tshuaj yog 200 mg, tom qab ntawd 100 mg / hnub txhua lwm hnub.

Nrog rau cov mob hemodialysis thiab peritoneal lim ntshav, 100 mg txhua 24 teev. Qhov siab tshaj plaws niaj hnub rau daim siab ua haujlwm yog 400 mg / hnub.

Cov ntsiav tshuaj tau noj tag nrho, ntxuav nrog dej, ua ntej lossis thaum noj mov. Lub sijhawm kho yog txiav txim los ntawm kev nkag siab ntawm tus kab mob thiab cov duab hauv chaw soj ntsuam, kev kho yuav tsum txuas ntxiv tsawg kawg 3 hnub tom qab ploj ntawm cov tsos mob ntawm tus kab mob thiab ua tiav qhov ua kom lub cev kub. Hauv kev kho mob ntawm salmonella, chav kawm ntawm kev kho mob yog 7-8 hnub, nrog tus kabmob tsis cuam tshuam ntawm cov mob ntawm lub qhov mob ntawm lub qhov zis qis, chav kawm ntawm kev kho mob yog 3-5 hnub.

Pharmacological kev txiav txim

Ib tug dav-spectrum antimicrobial tus neeg sawv cev los ntawm pab pawg ntawm fluoroquinolones ua rau cov kab mob enzyme DNA gyrase, uas muab supercoiling, thiab lwm yam. kev ruaj ntseg ntawm cov kab mob DNA (kev puas tsuaj ntawm DNA txuas ua rau lawv tuag). Nws muaj cov nyhuv bactericidal.

Nquag ua tawm tsam cov kab mob me me ua rau beta-lactamases thiab loj hlob sai atypical mycobacteria. Rhiab: Staphylococcus aureus, Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter, Klebsiella spp. (suav nrog Klebsiella mob ntsws), Enterobacter spp., Hafnia, Proteus spp. (suav nrog Proteus mirabilis, Proteus vulgaris - indole zoo thiab indole tsis zoo), Salmonella spp., Shigella spp. (Nrog tus mob Shigella sonnei), Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, tus mob Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp., Serratia spp., Providencia spp., Haemophilus ducreyi, Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, Pob txuv Propionibacterium, Brucella spp.

Cov tshuaj tiv thaiv sib txawv rau cov tshuaj muaj los ntawm: Enterococcus faecalis, Streptococcus pyogenes, mob ntsws thiab viridans, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacteriumium tuberculosis, Mycobacterium tuberculosis, Mycobacterium monocytogenes, Gardnerella vaginalis.

Feem ntau, qhov tsis txaus ntseeg: Nocardia asteroides, kab mob anaerobic (e.g. Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacter spp., Fusobacterium spp., Clostridium difficile). Siv tsis tau rau Treponema pallidum.

Cov lus qhia tshwj xeeb

Nws tsis yog cov tshuaj ntawm kev xaiv rau kev mob ntsws vim mob ntsws. Tsis yog qhia rau kev kho mob ntawm tus mob tonsillitis.

Nws tsis pom zoo kom siv rau ntau tshaj 2 hli, yuav tsum muaj lub hnub ci, tiv thaiv teeb meem nrog UV hluav taws xob (teeb meem muaj roj mercury-quartz, solarium).

Yog tias muaj kev phiv los ntawm lub hauv nruab nrab lub paj hlwb, kev fab tshuaj, pseudomembranous colitis, kev tshem tawm yeeb tshuaj yog qhov tsim nyog. Nrog pseudomembranous mob plab, paub tseeb hais tias mob txoj hnyuv thiab / lossis histologically, kev tswj hwm qhov ncauj ntawm vancomycin thiab metronidazole yog qhia.

Tsis tshua muaj tshwm sim cov leeg pob txha caj qaum tuaj yeem tuaj yeem ua rau tawg ntawm cov leeg (feem ntau Achilles leeg), tshwj xeeb tshaj yog nyob rau cov neeg laus. Thaum muaj cov tsos mob ntawm leeg, nws yog ib qho tsim nyog yuav tsum tau kho tam sim ntawd, immobilize Achilles leeg thiab sab laj orthopedist.

Thaum lub sijhawm kho, ethanol yuav tsum tsis txhob noj.

Thaum siv cov tshuaj, cov poj niam tsis pom zoo kom siv cov tampons huv si vim muaj qhov pheej hmoo ntawm kev tawm tsam.

Tawm tsam keeb kwm ntawm kev kho mob, ib qho zuj zus ntawm chav kawm ntawm myasthenia gravis, qhov nce ntawm porphyria tawm tsam nyob rau hauv cov neeg mob yooj yim yog ua tau.

Tej zaum yuav ua rau muaj qhov tsis zoo tshwm sim hauv kev kuaj mob bacteriological ntawm tuberculosis (tiv thaiv kev tshaj tawm Mycobacterium tuberculosis).

Hauv cov neeg mob uas muaj lub siab lossis lub raum tsis ua haujlwm, yuav tsum saib ntshav ntawm ofloxacin yog tsim nyog. Hauv lub raum thiab hepatic tsis txaus, qhov kev pheej hmoo ntawm cov tshuaj lom neeg mob ntau ntxiv (txo cov koob tshuaj yuav tsum tau kho).

Hauv cov menyuam yaus, nws tsuas yog siv thaum muaj kev phom sij txog lub neej, suav txog qhov tshuaj tiv thaiv kev muaj txiaj ntsig thiab muaj kev pheej hmoo ntawm kev phiv tshuaj, thaum nws tsis tuaj yeem siv lwm yam, tsis muaj tshuaj lom. Qhov nruab nrab txhua hnub hauv qhov no feem ntau yog 7.5 mg / kg, qhov siab tshaj plaws yog 15 mg / kg.

Thaum kho nrog Ofloxin 200, kev saib xyuas yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm yam kev muaj feem phom sij uas xav tau kev nce siab ntawm cov kev xav thiab qhov ceev ntawm cov kev tiv thaiv psychomotor.

Dosage daim ntawv

200 mg zaj duab xis-coated ntsiav tshuaj.

Ib ntsiav tshuaj muaj

cov tshuaj nquag - ofloxacin 200.00 mg

tus zam: lactose monohydrate 95.20 mg, pob kws hmoov nplej 47.60 mg, povidone 25 - 12.00 mg, crospovidone 20.00 mg, poloxamer 0.20 mg, magnesium stearate 8.00 mg, talc 4.00 mg

zaj duab xis txheej zaj duab xis: hypromellose 2910/5 - 9.42 mg, polyethylene glycol 6000 - 0.53 mg, talc 0.70 mg, titanium dioxide (E171) - 2.35 mg

Cov ntsiav tshuaj uas muaj puag ncig, biconvex, pleev xim-dawb, dawb lossis yuav luag dawb, nrog kev pheej hmoo rau kev ua txhaum ntawm ib sab ntawm lub ntsiav tshuaj thiab cim "200" ntawm lwm sab.

Cov chaw muag tshuaj

Kev nqus tau tom qab noj tau nrawm thiab ua tiav. Qhov siab tshaj plaws hauv cov ntshav ntshav tau tiav hauv 1-3 teev tom qab ib koob ntawm 200 mg. Kev tshem tawm ib nrab-lub neej yog 4-6 teev (tsis hais los ntawm lub koob).

Hauv raum tsis ua haujlwm, cov koob tshuaj yuav tsum tau txo.

Tsis pom muaj qhov sib txuam nrog rau kev noj qab haus huv nrog zaub mov kom pom.

Cov Tshuaj Hauv Tshuaj

Ofloxacin yog tshuaj tua kabmob ntawm pawg quinolone, uas muaj cov nyhuv bactericidal. Lub tshuab tseem ceeb ntawm kev txiav txim yog qhov tshwj xeeb inhibition ntawm cov kab mob enzyme DNA gyrase. Lub DNA gyrase enzyme tau koom nrog hauv DNA replication, hloov pauv, kho, thiab rov ua kom tiav. Kev txwv tsis pub ntawm DNA gyrase enzyme ua rau kev ncab thiab kev puas tsuaj ntawm cov kab mob DNA thiab ua rau cov kab mob tuag.

Antibacterial spectrum ntawm kev nkag siab ntawm cov kab mob me me mus rau ofloxacin.

Cov kab mob me me nkag siab ntawm ofloxacin: Dab Tsi Staphylococcusaureus(suav nrog methicillin tiv tausStaphylococci),Dab Tsi Staphylococcusphaum mob daim tawv nqaij,Neisseriahom,Esherichiacoli,Citrobtab sisdaim tawv,Klebsiella,Enterobacter,Hafnia,Kev ua Proteus(suav nrog indole-zoo thiab indole-negative),Haemophiluskhaub thuas,Chlamydie,Legionella,Gardnerella.

Cov kab mob sib txawv nrog lub rhiab sib txawv rau ofloxacin: Streptococci,Serratiamarcescens,PseudomonasaeruginosathiabMycoplasmas.

Cov kab mob me me tiv (tsis raug mob) rau ofloxacin: muab ua piv txwv Bacteroideshom,Tus kab mob Eubhom,Fusobacteriumhom,Peptococci,Peptostreptococci.

Tsuas tshuaj thiab tswj hwm

Sab hauv, 30-60 feeb ua ntej noj mov, ntxuav nrog ib qho me me ntawm cov kua, rau cov laus - 200-400 mg 2 zaug hauv ib hnub, lossis 400-800 mg 1 lub sijhawm hauv ib hnub, chav kawm - 7-10 hnub. Qhov koob tshuaj txhua hnub yog 200-800 mg. Thaum lub siab tsis ua hauj lwm siab - tsis ntau tshaj 400 mg, qhov koob tshuaj yog nyob ntawm Cl creatinine: nrog Cl 20-50 ml / min, thawj koob yog 200 mg, tom qab 100 mg txhua 24 teev, nrog Cl tsawg dua 20 ml / min thawj koob yog 200 mg, tom qab ntawd 100 mg txhua 48 teev

Rau cov menyuam yaus (thaum muaj xwmtxheej ceev), tag nrho cov tshuaj txhua hnub yog 7.5 mg / kg lub cev hnyav (tsis ntau dua 15 mg / kg).

Kev tiv thaiv kev nyab xeeb

Kev txiav txim siab yuav tsum tau muab rau qhov txo qis hauv qhov kev tawm tsam tus kws kho mob (qhia nrog ceev faj thaum tsav tsheb). Hauv cov menyuam yaus, kev siv yog ua tau tsuas yog thaum muaj neeg mob hnyav (thaum qhov xav pom ntawm txoj kev kho ntau tshaj qhov kev pheej hmoo ntawm kev mob tshwm sim).

Ceev faj yuav tsum tau kho rau atherosclerosis ntawm cerebral hlab ntsha, cerebrovascular kev huam yuaj, lub raum tsis ua haujlwm.

Pharmacological pawg

Antimicrobial tus sawv cev rau kev siv system. Fluoroquinolones. PBX code J01M A01.

• Cov mob txeeb zig thiab sab qaum
• ua pa ntawm kab mob
• kis ntawm daim tawv nqaij thiab cov nqaij mos,
• tsis mob hlwb gonorrhea ntawm tso zis thiab lub ncauj tsev menyuam,
• tsis mob gonococcal ua mob rau txoj hlab zis thiab ncauj tsev menyuam.

Kev phiv tshuaj

Nyob rau ntawm daim tawv nqaij thiab subcutaneous cov ntaub so ntswg: khaus, tawm pob, urticaria, hlwv, yaug tawm, hyperhidrosis, pustular ua pob, erythema multiforme, vascular purpura, Stevens-Johnson syndrome, Lyell's syndrome, cov kab mob ua ntej, ua kom zoo nkauj, ua rau lub cev nqaij tawv, ua kom lub cev tsis haum rau hauv daim ntawv. discoloration ntawm daim tawv nqaij los yog exfoliation ntawm ntsia hlau.

Ntawm ib feem ntawm lub cev tiv thaiv kab mob: cov tshuaj tiv thaiv tsis haum lub cev, nrog rau qhov tshuaj tiv thaiv anaphylactic / anaphylactoid, angioedema (suav nrog rau ntawm tus nplaig, larynx, pharynx, o / o ntawm lub ntsej muag), anaphylactic / anaphylactoid kev poob siab. Anaphylactic / tshuaj tiv thaiv anaphylactoid tuaj yeem tsim tawm sai sai tom qab kev tswj hwm ntawm ofloxacin, suav nrog cov tsos mob ntawm tus mob anaphylaxis, tachycardia, kub taub hau, txog siav, ua tsis taus pa, mob hlwb, mob taub hau, mob vasculitis, uas tshwj tsis yog tuaj yeem ua rau necrosis, eosinophilia. Hauv qhov no, kev siv tshuaj yuav tsum tau txuas mus ntxiv thiab lwm txoj kev kho yuav tsum tau pib.

Ntawm ib feem ntawm cov hlab plawv: tachycardia, ntshav tsis ntev ntawm cov hlab ntsha hypotension, lub cev qhuav dej (thaum muaj teeb meem ntshav liab ntau heev, kev kho yuav tsum tsis ua haujlwm) ventricular arrhythmia, flutter-ventricular fibrillation (pom feem ntau hauv cov neeg mob uas muaj kev pheej hmoo rau kev ncua ntev ntawm QT ntu) ntawm ECG, kev ncua ntev ntawm QT interval. Cov.

Los ntawm cov kab mob hauv lub cev: mob taub hau, kiv taub hau, kev nyuaj siab, pw tsaug zog, pw tsaug zog, tsaug zog, ntxhov siab, ntxhov siab, tsis meej pem, tsis meej pem, tsis nco qab, npau suav phem, ua rau qeeb ntawm cov tshuaj tiv thaiv, nce intracranial siab, paresthesia, hnov ​​ntxhiab lossis sensorimotor neuropathy, tshee thiab lwm cov tsos mob ntawm tus neeg mob ntxiv, ua kom cov leeg tsis sib haum (tsis txaus, lub cev tsis ruaj khov), kev puas siab puas ntsws, kev xav tua tus kheej / ua yeeb yam, hnov ​​qab.

Los ntawm lub plab zom mov: tsis nco qab noj mov, xeev siab, ntuav, gastralgia, mob plab los yog mob, raws plab, enterocolitis, qee zaum hemorrhagic enterocolitis, flatulence dysbiosis, pseudomembranous colitis.

Hepatobiliary system: nce theem ntawm daim siab enzymes thiab qib bilirubin, mob cholestatic daj ntseg, kab mob siab.

Los ntawm cov kab mob tso zis: lub raum tsis ua haujlwm nrog kev nce ntxiv ntawm urea, creatinine mob raum tsis ua haujlwm, mob ntsws tsis ua haujlwm ntev.

Los ntawm cov leeg mus rau lub cev: nqaij leeg mob leeg, mob leeg, myalgia, arthralgia, mob leeg, mob caj dab (suav nrog Achilles leeg), uas tuaj yeem tshwm sim 48 teev tom qab pib siv ofloxacin thiab tuaj yeem yog ob tog, rhabdomyolysis thiab / lossis myopathy leeg tsis muaj zog.

Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: neutropenia, leukopenia, ua haujlwm ntshav, hemolytic anemia, eosinophilia, thrombocytopenia, pancytopenia agranulocytosis, inhibition ntawm cov hlwb pob txha hematopoiesis.

Los ntawm cov khoom hauv lub siab: qhov muag khaus, lub qhov muag daj, tsis pom kev, tsis hnov ​​tsw, hnov ​​tsw, photophobia, tinnitus, hnov ​​lus tsis zoo.

Los ntawm cov txheej txheem ua pa: hnoos, nasopharyngitis, ua tsis taus pa, bronchospasm, ua xua mob ntsws, ua tsis taus pa hnyav.

Kev ntshaib plab hauv lub cev: hypoglycemia lossis hyperglycemia (hauv cov neeg mob ntshav qab zib mellitus).

Cov kab mob: fungal kab mob, candidiasis, tsis kam mus rau pathogenic microorganisms.

Lwm yam: muaj kev tawm tsam ntawm cov pob qij txha rau hauv cov neeg mob uas muaj porphyria, malaise, qaug zog.

Siv thaum cev xeeb tub lossis lactation

Ofloxacin yog contraindicated rau cov poj niam thaum cev xeeb tub thiab lactation vim yog tsis muaj kev paub nrog cov tshuaj. Ofloxacin kev zam rau niam mis yog qhov tseem ceeb.

Yog tias yuav tsum siv cov tshuaj, kev pub niam mis rau lub cev yuav tsum tsis ua ntxiv rau lub sijhawm kho.

Cov tshuaj yog contraindicated rau hauv cov menyuam yaus thiab cov hluas.

Daim ntawv thov nta

Ua ntej pib kev kho mob, nws yog ib qhov tsim nyog yuav tau ua qhov kev ntsuam xyuas: kab lis kev cai ntawm microflora thiab kev txiav txim siab ntawm rhiab heev rau ofloxacin.

Thaum siv ofloxacin, nws yog qhov yuav tsum tau tswj kom muaj dej txaus. Hauv cov neeg mob uas lub raum lub raum thiab lub siab ua haujlwm, cov tshuaj yuav tsum tau txiav txim siab nrog ceev faj thiab saib xyuas lub chaw kuaj ntshav ntawm lub siab thiab lub raum ua haujlwm. Rau cov neeg mob uas lub raum tsis ua hauj lwm zoo, qhov tau muab tshuaj ntawm ofloxacin yuav tsum kho, muab ncua sij hawm tso.

Yog tias ua rau lub siab ua haujlwm tsis zoo, ofloxacin siv ua tib zoo vim tias muaj peev xwm ua rau daim siab ua haujlwm tsis zoo. Txog rau fluoroquinolones, cov neeg kis tau tus mob muaj kab mob siab ntau, tuaj yeem ua rau daim siab ua haujlwm (ua ntej tuag). Tsum kev kho mob thiab sab laj tus kws kho mob yog tias pom thiab cov tsos mob ntawm daim siab tshwm sim, xws li tsis nco qab, daj ntseg, tso zis tsaus nti, khaus, thiab mob plab.

Cov kab mob tshwm sim los ntawm Clostridium difficile. Kev zawv plab, tshwj xeeb tshaj yog mob hnyav, pheej yaum, lossis sib xyaw nrog ntshav, lub sijhawm lossis tom qab kho nrog ofloxacin tuaj yeem yog cov tsos mob ntawm pseudomembranous colitis. Yog tias xav tias mob pseudomembranous mob plab, ofloxacin yuav tsum tawm tam sim ntawd thiab kev siv tshuaj tua kab mob uas tsim nyog yuav tsum tau pib yam tsis muaj kev ncua (xws li, vancomycin, teicoplanin lossis metronidazole). Hauv qhov xwm txheej no, tshuaj uas txwv plab hnyuv plab yog contraindicated.

Cov tshuaj tiv thaiv kev tsis haum siab thiab kev fab tshuaj rau fluoroquinolones tau tshaj tawm tom qab siv thawj zaug. Cov tshuaj tiv thaiv anaphylactic thiab anaphylactoid tuaj yeem nkag mus rau hauv kev poob siab, yog kev hem thawj rau lub neej, txawm tias tom qab siv thawj zaug. Hauv qhov no, ofloxacin yuav tsum raug txiav thiab kev kho mob tsim nyog.

Cov neeg mob noj ofloxacin yuav tsum zam kev tiv tshav tiv thaiv tshav ntuj UV thiab UV duab (ua kom lub txaj pw) vim yog qhov ua rau raug tshem tawm. Yog tias muaj qhov cuam tshuam raws lub zog (piv txwv li, zoo xws li hnub zawv zaws) tshwm sim, ofloxacin txoj kev kho yuav tsum tsis ua mus ntxiv.

Cov xwm txheej ntawm qhov tsis hnov ​​mob lossis lub cev muaj zog (sensorimotor peripheral neuropathy) tau qhia tawm hauv cov neeg mob noj fluoroquinolones, suav nrog ofloxacin Nrog rau kev txhim kho neuropathy, ofloxacin yuav tsum tau txiav.

Yog tias muaj kev cuam tshuam rau txoj kev mob ntshav ntawm cov ntshav liab, yuav tsum tsis txhob siv cov tshuaj ntxiv lawm.

QT luv ncua ntev. Thaum noj cov tshuaj fluoroquinolones, muaj tsawg tus neeg mob lub sijhawm ntev tshaj ntawm QT ntu nruab nrab. Kev ceev faj yuav tsum tau siv thaum noj fluoroquinolones, suav nrog ofloxacin, hauv cov neeg mob uas paub txog kev pheej hmoo ntawm kev ua qog QT, cov neeg mob laus, nrog cov mob electrolyte tsis txaus (hypokalemia, hypomagnesemia), yug los yog tau ntev ntawm QT ntu, mob plawv (mob plawv tsis ua haujlwm, myocardial infarction) bradycardia).

Mob pob qij txha. Muaj qee zaus, kev kho nrog quinolones tuaj yeem ua rau leeg leeg hlwb, tuaj yeem ua rau mob pob txha, nrog rau cov leeg ntawm Achilles. Cov neeg mob lub caij ntuj sov feem ntau yuav raug rau mob leeg hlwb. Kev pheej hmoo ntawm cov leeg pob txha yog txhim kho los ntawm kev kho mob nrog corticosteroids. Yog tias mob tendinitis yog xav tias tsam thawj cov tsos mob los yog mob tshwm sim, ofloxacin kev kho mob yuav tsum nres tam sim ntawd thiab kev ntsuas tsim nyog (piv txwv, kom paub meej txog immobilization).

Cov neeg mob uas ua tsis taus lub hauv nruab nrab cov hlab hlwb ua haujlwm, nrog rau cov kab mob hlwb, nrog rau kev mob hlwb los yog keeb kwm ntawm ofloxacin yuav tsum tau ceeb toom nrog kom ceev faj.

Hauv cov neeg mob ntshav qab zib, ofloxacin tuaj yeem ua rau muaj zog ntawm hypoglycemic nyhuv ntawm insulin, tshuaj tiv thaiv kab mob hauv lub qhov ncauj (suav nrog glibenclamide). Cov neeg mob no yuav tsum tswj hwm lawv cov piam thaj hauv ntshav.

Nrog kev kho mob ntev lossis rov ua dua ntawm cov tshuaj tua kab mob, kis kab mob thiab kev loj hlob ntawm cov kab mob tiv taus me me tuaj yeem ua tau. Nrog txoj kev txhim kho ntawm kev kis mob thib ob, yuav tsum ua cov kev ntsuas tsim nyog.

Thaum kho nrog ofloxacin, zoo li lwm yam tshuaj ntawm pawg no, qhov cuam tshuam ntawm qee yam kab mob Pseudomonas aeruginosa tuaj yeem loj hlob sai.

Ofloxacin tsis yog siv tshuaj rau kev xaiv rau kev kho mob ntsws mob los ntawm pneumococci lossis mycoplasmas, lossis tonsillar tonsillitis los ntawm β-hemolytic streptococci.

Lub sijhawm kho yuav tsum tsis txhob haus dej haus cawv.

Ofloxacin yog tshuaj nrog kev ceev faj rau cov neeg mob uas muaj keeb kwm ntawm myasthenia gravis.

Cov neeg mob noj cov vitamin K antagonists yuav tsum saib xyuas ntshav coagulation thaum noj ofloxacin thiab vitamin K antagonists (warfarin) los ntawm kev pheej hmoo muaj feem yuav ua rau ntshav coagulation ntau ntxiv (lub sijhawm prothrombin) thiab / lossis los ntshav.

Cov tshuaj muaj lactose, yog li ntawd, cov neeg mob uas tsis tshua muaj keeb kwm ntawm galactose intolerance, lactase deficiency lossis glucose-galactose malabsorption syndrome yuav tsum tsis txhob siv cov tshuaj.

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem

Thaum muaj kev phiv tshuaj los ntawm cov leeg poob siab, cov kabmob ntawm lub zeem muag, nws raug nquahu kom tsis txhob tsav tsheb lossis ua haujlwm nrog cov txheej txheem.

Kev sib cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam.

Nrog rau kev tswj fwm ntawm ofloxacin nrog cov tshuaj tiv thaiv kab mob siab, ua rau cov ntshav siab tuaj yeem ua tau. Hauv cov xwm txheej zoo li no, lossis yog tias ofloxacin siv rau tshuaj loog nrog barbiturates, nws yog qhov yuav tsum tau soj ntsuam kev ua haujlwm ntawm txoj hlab plawv.

Nws yog contraindicated yuav siv ofloxacin ib txhij nrog cov tshuaj uas ncua sijhawm QT luv (hauv chav kawm IA tshuaj tiv thaiv kab mob - quinine, procainamide thiab chav kawm III - amiodarone, sotalol, tricyclic antidepressants, macrolides).

Kev siv ib txhij ntawm ofloxacin nrog cov tshuaj tsis muaj tshuaj steroidal (suav nrog rau cov qub ntawm propionic acid), derivatives ntawm nitroimidazole thiab methylxanthines nce qhov kev pheej hmoo ntawm cov teebmeem nephrotoxic, txo qis kev qaug dab peg, uas tuaj yeem ua rau kev txhim kho ntawm qaug dab peg.

Kev tswj hwm ib txhij ntawm ofloxacin nyob rau hauv cov koob tshuaj loj nrog cov tshuaj uas tso tawm los ntawm tubular tso pa tuaj yeem ua rau muaj ntshav ntau ntxiv vim qhov txo qis hauv lawv cov zis.

Txij li thaum siv tib txhij ntawm feem ntau quinolones, suav nrog ofloxacin, tiv thaiv qhov kev ua si enzymatic ntawm cytochrome P450, kev tswj hwm ib txhij ntawm ofloxacin nrog cov tshuaj uas metabolized los ntawm cov kab mob no (cyclosporine, theophylline, methylxanthine, caffeine, warfarin) rub lub sijhawm ntev txog ib nrab ntawm cov tshuaj no.

Nrog rau kev tswj hwm tib lub sijhawm ntawm ofloxacin thiab vitamin K kev thaiv kev lag luam, nws yog ib qho tsim nyog los soj ntsuam cov ntshav coagulation system tas li.

Kev siv ib txhij ntawm cov tshuaj nrog antacids muaj cov calcium, magnesium lossis aluminium, nrog cov hlau nplaum ua ke, nrog ferrous lossis ferric iron, nrog multivitamins muaj zinc, txo qhov nqus ntawm ofloxacin. Yog li, qhov luv nruab nrab ntawm kev noj cov tshuaj no yuav tsum yog tsawg kawg 2:00.

Nrog rau kev siv ntawm ofloxacin nrog lub qhov ncauj hypoglycemic thiab insulin, hypoglycemia lossis hyperglycemia yog ua tau. Yog li ntawd, nws yog ib qho tsim nyog los soj ntsuam cov tsis los them nyiaj rau lawv. Nrog rau kev siv ib txhij nrog glibenclamide, kev nce qib ntawm glibenclamide hauv cov ntshav ntshav yog ua tau.

Thaum siv nrog cov tshuaj uas hloov cov zis (carbonic anhydrase inhibitors, citrates, sodium bicarbonate), kev pheej hmoo ntawm crystalluria thiab nephrotic nce ntxiv.

Kev siv tib lub sijhawm ntawm ofloxacin nrog probenecid, cimetidine, furosemide, methotrexate ua rau kev nce hauv cov siab ntawm ofloxacin hauv cov ntshav ntshav.

Thaum kawm tshawb fawb. Thaum kho nrog ofloxacin, cov txiaj ntsig tsis zoo yuav raug pom hauv kev txiav txim siab ntawm opiates lossis porphyrins nyob rau hauv cov zis. Yog li, nws yog qhov yuav tsum tau siv cov txheej txheem tshwj xeeb dua.

Ofloxacin tuaj yeem tiv thaiv txoj kev loj hlob ntawm Mycobacterium tuberculosis thiab qhia tau qhov tsis zoo tsis zoo hauv kev tshawb fawb bacteriological los tshawb nrhiav tus kab mob ntsws.